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TDMS Study 88036-03 Pathology Tables

NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99
Route: DOSED FEED                                                                                                 Time: 11:42:51

                                                      2 YEAR CHRONIC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  84-65-1

       Lock Date:  07/23/97

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14            7           12            7            6                        
    Natural Death                                     13            3            3            6            4                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           40           35           37           40                        

  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (50)                      
   Intestine Large, Rectum                            (50)         (50)         (49)         (50)         (50)                      
      Leiomyosarcoma                                                                                       1 (2%)                   
   Intestine Large, Cecum                             (50)         (49)         (49)         (50)         (49)                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (49)                      
      Leiomyosarcoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)         (49)                      
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Tissue NOS     1 (2%)                                                                       
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                                        2 (4%)       5 (10%)      3 (6%)       3 (6%)                   
      Hepatocellular Adenoma, Multiple                                           1 (2%)       1 (2%)                                
   Mesentery                                          (4)          (4)          (6)          (3)          (2)                       
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (17%)                                            
      Carcinoma, Metastatic, Kidney                                                           1 (33%)                               
   Oral Mucosa                                        (1)                       (1)                                                 
      Pharyngeal, Squamous Cell Papilloma                                        1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)         (49)                      
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)         (48)                      
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (49)                      
   Tongue                                                                                                 (1)                       
      Squamous Cell Papilloma                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (48)                      
      Carcinoma, Metastatic, Mammary Gland                                                                 1 (2%)                   
      Schwannoma Benign                                                                                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (49)                      
      Adenoma                                                       1 (2%)                                                          
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (49)                      
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                                                    1 (2%)       1 (2%)       2 (4%)                   
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)         (49)                      
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (42)         (44)         (48)         (48)         (41)                      
   Pituitary Gland                                    (50)         (50)         (50)         (49)         (49)                      
      Squamous Cell Carcinoma, Metastatic, Nose                                  1 (2%)                                             
      Pars Distalis, Adenoma                          20 (40%)     22 (44%)     23 (46%)     17 (35%)     19 (39%)                  
   Thyroid Gland                                      (50)         (50)         (50)         (50)         (49)                      
      C-Cell, Adenoma                                  5 (10%)      4 (8%)       5 (10%)     10 (20%)      9 (18%)                  
      C-Cell, Carcinoma                                                                                    1 (2%)                   
      Follicular Cell, Adenoma                         1 (2%)                                              1 (2%)                   
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Fibrous Histiocytoma                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (46)         (48)         (49)         (48)                      
      Adenoma                                          2 (4%)       2 (4%)       3 (6%)       2 (4%)       1 (2%)                   
      Carcinoma                                        2 (4%)       1 (2%)       2 (4%)                                             
      Bilateral, Adenoma                               1 (2%)       1 (2%)       1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)         (49)                      
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa-Theca Tumor Malignant                                                                      1 (2%)                   
      Granulosa-Theca Tumor Benign                                  1 (2%)                                                          
      Luteoma                                          1 (2%)                                                                       
   Oviduct                                                         (1)          (1)                                                 
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (100%)                                           
   Uterus                                             (50)         (50)         (50)         (50)         (49)                      
      Polyp Stromal                                    6 (12%)      9 (18%)      9 (18%)      4 (8%)       5 (10%)                  
      Sarcoma Stromal                                               1 (2%)                                                          
      Schwannoma Malignant                                                                                 1 (2%)                   
      Cervix, Leiomyosarcoma                                                                  2 (4%)                                
      Cervix, Polyp Stromal                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
   Lymph Node                                         (10)                      (1)          (1)                                    
      Lumbar, Fibrous Histiocytoma, Metastatic,                                                                                     
           Tissue NOS                                  1 (10%)                                                                      
      Mediastinal, Carcinoma, Metastatic, Islets,                                                                                   
           Pancreatic                                                            1 (100%)                                           
      Mediastinal, Carcinoma, Metastatic, Kidney                                              1 (100%)                              
   Lymph Node, Mandibular                             (49)         (49)         (50)         (48)         (47)                      
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)         (49)                      
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)         (49)                      
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
   Thymus                                             (46)         (48)         (48)         (49)         (46)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma                                        1 (2%)                    1 (2%)       2 (4%)       3 (6%)                   
      Fibroadenoma                                    19 (38%)     20 (40%)     20 (40%)     18 (36%)     13 (26%)                  
      Fibroadenoma, Multiple                           6 (12%)      6 (12%)      6 (12%)      6 (12%)      6 (12%)                  
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Keratoacanthoma                                               1 (2%)                                                          
      Trichoepithelioma                                                                                    1 (2%)                   
      Subcutaneous Tissue, Fibroma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Mandible, Carcinosarcoma, Metastatic,                                                                                         
          Zymbal's Gland                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (49)                      
      Astrocytoma Malignant                                                      1 (2%)       1 (2%)                                
      Oligodendroglioma Malignant                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (48)                      
      Alveolar/Bronchiolar Adenoma                                  1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                 1 (2%)                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Carcinoma, Metastatic, Mammary Gland                                                                 1 (2%)                   
      Carcinosarcoma, Metastatic, Zymbal's Gland       1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Nose                                  1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Nasolacrimal Duct, Squamous Cell Carcinoma                                 1 (2%)                                             
   Trachea                                            (50)         (50)         (50)         (50)         (49)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                              (1)                                                 
      Squamous Cell Carcinoma, Metastatic, Nose                                  1 (100%)                                           
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
      Carcinosarcoma                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (49)                      
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Tissue NOS     1 (2%)                                                                       
      Bilateral, Renal Tubule, Adenoma                                           1 (2%)       1 (2%)                                
      Renal Tubule, Adenoma                                         4 (8%)       7 (14%)      6 (12%)     12 (24%)                  
      Renal Tubule, Adenoma, Multiple                                            1 (2%)                                             
      Renal Tubule, Carcinoma                                       2 (4%)                    1 (2%)       2 (4%)                   
      Renal Tubule, Carcinoma, Metastatic, Kidney                                                          1 (2%)                   
   Urinary Bladder                                    (49)         (49)         (49)         (50)         (49)                      
      Transitional Epithelium, Carcinoma                                                                   1 (2%)                   
      Transitional Epithelium, Papilloma                                                      1 (2%)       1 (2%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Leukemia Mononuclear                            18 (36%)      1 (2%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          46          47          42          45                           
     Total Primary Neoplasms                           91          83          98          80          86                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          45          44          40          41                           
     Total Benign Neoplasms                            64          74          87          71          75                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24           9          11           9          10                           
     Total Malignant Neoplasms                         27           9          11           9          11                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2           1           2                           
     Total Metastatic Neoplasm                          5                      10           6           3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           21           16           14           17                        
    Natural Death                                      7            6           12           10           11                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           23           22           26           22                        
    Natural Death                                      1                                                                            

  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (49)                      
      Fibrosarcoma, Metastatic, Salivary Glands                     1 (2%)                                                          
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (50)                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)         (50)                      
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Hepatocellular Carcinoma                                                                1 (2%)       1 (2%)                   
      Hepatocellular Adenoma                           1 (2%)       3 (6%)       4 (8%)       3 (6%)       2 (4%)                   
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Mesentery                                          (10)         (4)          (6)          (7)          (6)                       
      Fibrosarcoma, Metastatic, Skin                                                                       1 (17%)                  
   Oral Mucosa                                        (1)                       (2)                       (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
      Squamous Cell Papilloma                          1 (100%)                  1 (50%)                                            
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Fibrosarcoma, Metastatic, Skin                                                                       1 (2%)                   
      Acinus, Adenoma                                  1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (48)         (50)         (47)                      
      Fibrosarcoma                                                  1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)       1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (50)                      
      Squamous Cell Papilloma                                                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Schwannoma Malignant                                                                    1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (50)                      
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          6 (12%)      7 (14%)     10 (20%)      6 (12%)     10 (20%)                  
      Bilateral, Pheochromocytoma Benign               2 (4%)       1 (2%)                                 1 (2%)                   
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)         (50)                      
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (49)         (48)         (48)         (50)         (45)                      
      Adenoma                                                                                 1 (2%)       1 (2%)                   
      Carcinoma, Metastatic, Thyroid Gland                          2 (4%)                                                          
   Pituitary Gland                                    (50)         (50)         (49)         (50)         (50)                      
      Pars Distalis, Adenoma                          15 (30%)     15 (30%)     11 (22%)     11 (22%)      9 (18%)                  
   Thyroid Gland                                      (50)         (50)         (48)         (50)         (47)                      
      Fibrosarcoma, Metastatic, Salivary Glands                     1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Salivary                                                                                    
          Glands                                                    1 (2%)                                                          
      Bilateral, C-Cell, Adenoma                                                              1 (2%)       1 (2%)                   
      C-Cell, Adenoma                                  2 (4%)       6 (12%)      6 (13%)      6 (12%)      3 (6%)                   
      C-Cell, Carcinoma                                             2 (4%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                    4 (8%)       1 (2%)       1 (2%)                   
      Follicular Cell, Carcinoma                       1 (2%)       3 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Chemodectoma Benign                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)         (50)                      
   Preputial Gland                                    (50)         (49)         (50)         (49)         (50)                      
      Adenoma                                          3 (6%)       8 (16%)      7 (14%)      4 (8%)       2 (4%)                   
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)       5 (10%)      3 (6%)                   
      Bilateral, Adenoma                                            1 (2%)                                                          
   Prostate                                           (50)         (50)         (50)         (50)         (50)                      
   Seminal Vesicle                                    (50)         (50)         (50)         (49)         (50)                      
   Testes                                             (50)         (50)         (50)         (50)         (50)                      
      Interstitial Cell, Adenoma                       6 (12%)      5 (10%)      3 (6%)       3 (6%)       4 (8%)                   
      Interstitial Cell, Adenoma, Multiple            40 (80%)     41 (82%)     44 (88%)     44 (88%)     44 (88%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
   Lymph Node                                         (8)          (3)          (1)          (1)          (2)                       
      Mediastinal, Histiocytic Sarcoma                                                        1 (100%)                              
   Lymph Node, Mandibular                             (50)         (50)         (47)         (50)         (47)                      
      Fibrosarcoma, Metastatic, Salivary Glands                     1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Salivary                                                                                    
          Glands                                                    1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)         (49)                      
   Spleen                                             (50)         (50)         (50)         (50)         (50)                      
      Fibroma                                                                                 1 (2%)                                
      Fibrosarcoma                                     1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (46)         (44)         (45)         (46)         (41)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (47)         (46)         (50)         (47)                      
      Fibroadenoma                                     1 (2%)       5 (11%)                   7 (14%)      4 (9%)                   
      Fibroadenoma, Multiple                                                     1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Basal Cell Adenoma                               1 (2%)       1 (2%)                                                          
      Keratoacanthoma                                               2 (4%)       3 (6%)       2 (4%)       5 (10%)                  
      Squamous Cell Papilloma                          1 (2%)                                              2 (4%)                   
      Trichoepithelioma                                1 (2%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     5 (10%)      4 (8%)       1 (2%)       5 (10%)      2 (4%)                   
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Histiocytic Sarcoma                                                1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Melanoma Malignant                                                 3 (6%)                                
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Osteosarcoma                                     1 (2%)                                                                       
      Maxilla, Osteosarcoma                                                                   1 (2%)                                
      Tibia, Chondroma                                 1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
      Osteosarcoma, Metastatic, Bone                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Astrocytoma Malignant                                                      2 (4%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Meningioma Malignant                                                                                 1 (2%)                   
      Oligodendroglioma Malignant                                                                          1 (2%)                   
   Spinal Cord                                        (1)                                                 (2)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)                    2 (4%)                                
      Carcinoma, Metastatic, Preputial Gland                                                               1 (2%)                   
      Chordoma, Metastatic, Uncertain Primary Site                  1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Respiratory Epithelium, Adenoma                  1 (2%)                                                                       
      Respiratory Epithelium, Papilloma                                                       1 (2%)                                
   Trachea                                            (50)         (50)         (50)         (50)         (49)                      
      Fibrosarcoma, Metastatic, Salivary Glands                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (2)                                                 
      Carcinoma                                                                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Bilateral, Renal Tubule, Adenoma                                           1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       3 (6%)       8 (16%)      5 (10%)      3 (6%)                   
      Renal Tubule, Oncocytoma Benign                                            1 (2%)                                             
      Transitional Epithelium, Papilloma                                         2 (4%)                    1 (2%)                   
   Urinary Bladder                                    (50)         (50)         (50)         (50)         (49)                      
      Transitional Epithelium, Papilloma                            1 (2%)       3 (6%)       7 (14%)      3 (6%)                   
                                                                                                                                    
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            25 (50%)      2 (4%)       1 (2%)       5 (10%)      7 (14%)                  
      Mesothelioma Malignant                           4 (8%)       4 (8%)       5 (10%)      4 (8%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  11                                                               
NTP Experiment-Test: 88036-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          50          49                           
     Total Primary Neoplasms                          129         121         131         138         114                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          50          48          50          48                           
     Total Benign Neoplasms                            94         105         114         112          99                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          13          15          18          14                           
     Total Malignant Neoplasms                         35          16          17          23          15                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           6                       1           3                           
     Total Metastatic Neoplasm                          1          10                       1           4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              3                                       
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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