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TDMS Study 88036-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                       ANTHRAQUINONE                                     DATE: 02/25/99       
EXPERIMENT: 88036 TEST: 03                                                                                     TIME: 11:47:29       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-25337                              ROUTE: DOSED FEED                                              NTP C#: C88036       
PATHOLOGIST: SINGER, A.                                                                                        CAS: 84-65-1         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        2 YEAR CHRONIC RATS                                                         
                                                                                                                                    

               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                       ANTHRAQUINONE                                     DATE: 02/25/99

EXPERIMENT: 88036 TEST: 03                                                                                     TIME: 11:47:29
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-25337                              ROUTE: DOSED FEED                                              NTP C#: C88036
PATHOLOGIST: SINGER, A.                                                                                        CAS: 84-65-1

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Brain
                                                 Clitoral/Preputial Gland
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                       ANTHRAQUINONE                                     DATE: 02/25/99     
EXPERIMENT: 88036 TEST: 03                                                                                     TIME: 11:47:29     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-25337                              ROUTE: DOSED FEED                                              NTP C#: C88036     
PATHOLOGIST: SINGER, A.                                                                                        CAS: 84-65-1       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  ANTHRAQUINONE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Kidney: Renal Tubule                   Adenoma
                                       Carcinoma or Adenoma
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Skin                                   Keratoacanthoma
                                       Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
                                       Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
Urinary Bladder                        Carcinoma or Papilloma
                                       Papilloma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Mesothelioma: Benign, Malignant, NOS
                                       Mesothelioma: Malignant
                                       Malignant Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Clitoral/Preputial Gland               Carcinoma or Adenoma
Kidney: Renal Tubule                   Adenoma
                                       Carcinoma or Adenoma
Liver                                  Hepatocellular Adenoma
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
Thyroid Gland: C-Cell                  Adenoma
                                       Carcinoma or Adenoma
Urinary Bladder                        Carcinoma or Papilloma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/50 (16%)       8/50 (16%)       10/50 (20%)      6/50 (12%)       11/50 (22%)                      |
|POLY-3 ADJUSTED (b)|        19.5%            18.0%            23.1%            13.7%            26.5%                            |
|TERMINAL (d)       |        6/22 (27%)       4/23 (17%)       5/22 (23%)       5/26 (19%)       6/22 (27%)                       |
|FIRST INCIDENCE    |        681              642              643              727              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.297          P=0.536N         P=0.454          P=0.252N         P=0.328                          |
|POLY 3             |        P=0.276          P=0.539N         P=0.446          P=0.336N         P=0.310                          |
|POLY 1.5           |        P=0.276          P=0.570N         P=0.421          P=0.361N         P=0.299                          |
|POLY 6             |        P=0.278          P=0.497N         P=0.485          P=0.302N         P=0.331                          |
|LOGISTIC REGRESSION|        P=0.263          P=0.505N         P=0.496          P=0.238N         P=0.312                          |
|COCH-ARM / FISHERS |        P=0.294          P=0.607N         P=0.398          P=0.387N         P=0.306                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             2.1%             4.2%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              730 (T)          730 (T)          536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.106          (e)              P=0.584          P=0.595          P=0.281                          |
|POLY 3             |        P=0.088          (e)              P=0.509          P=0.518          P=0.263                          |
|POLY 1.5           |        P=0.081          (e)              P=0.503          P=0.509          P=0.248                          |
|POLY 6             |        P=0.099          (e)              P=0.520          P=0.531          P=0.287                          |
|LOGISTIC REGRESSION|        P=0.056          (e)              P=0.584          P=0.595          P=0.165                          |
|COCH-ARM / FISHERS |        P=0.073          (e)              P=0.500          P=0.500          P=0.242                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/50 (16%)       9/50 (18%)       10/50 (20%)      7/50 (14%)       11/50 (22%)                      |
|POLY-3 ADJUSTED (b)|        19.5%            20.2%            23.1%            16.0%            26.5%                            |
|TERMINAL (d)       |        6/22 (27%)       4/23 (17%)       5/22 (23%)       6/26 (23%)       6/22 (27%)                       |
|FIRST INCIDENCE    |        681              642              643              727              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.321          P=0.574          P=0.454          P=0.348N         P=0.328                          |
|POLY 3             |        P=0.301          P=0.574          P=0.446          P=0.446N         P=0.310                          |
|POLY 1.5           |        P=0.300          P=0.541          P=0.421          P=0.473N         P=0.299                          |
|POLY 6             |        P=0.304          P=0.598N         P=0.485          P=0.409N         P=0.331                          |
|LOGISTIC REGRESSION|        P=0.286          P=0.603N         P=0.496          P=0.331N         P=0.312                          |
|COCH-ARM / FISHERS |        P=0.318          P=0.500          P=0.398          P=0.500N         P=0.306                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        1/50 (2%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.4%             2.1%             4.2%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        2/35 (6%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              730 (T)          730 (T)          536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.177          (e)              P=0.335          P=0.595          P=0.281                          |
|POLY 3             |        P=0.148          (e)              P=0.247          P=0.518          P=0.263                          |
|POLY 1.5           |        P=0.136          (e)              P=0.240          P=0.509          P=0.248                          |
|POLY 6             |        P=0.168          (e)              P=0.260          P=0.531          P=0.287                          |
|LOGISTIC REGRESSION|        P=0.104          (e)              P=0.335          P=0.595          P=0.165                          |
|COCH-ARM / FISHERS |        P=0.124          (e)              P=0.247          P=0.500          P=0.242                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma Malignant                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.6%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        1/22 (5%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              312              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.516N         (e)              P=0.240          (e)              (e)                              |
|POLY 3             |        P=0.510N         (e)              P=0.252          (e)              (e)                              |
|POLY 1.5           |        P=0.515N         (e)              P=0.246          (e)              (e)                              |
|POLY 6             |        P=0.503N         (e)              P=0.261          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.344N         (e)              P=0.284          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.516N         (e)              P=0.247          (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma Malignant                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              85               647              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.684N         (e)              P=0.500          P=0.523          (e)                              |
|POLY 3             |        P=0.676N         (e)              P=0.513          P=0.519          (e)                              |
|POLY 1.5           |        P=0.688N         (e)              P=0.507          P=0.510          (e)                              |
|POLY 6             |        P=0.658N         (e)              P=0.525          P=0.533          (e)                              |
|LOGISTIC REGRESSION|        P=0.563          (e)              (e)              P=0.403          (e)                              |
|COCH-ARM / FISHERS |        P=0.685          (e)              P=0.500          P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.6%             0.0%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        1/22 (5%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              312              ---              671                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.410          (e)              P=0.240          (e)              P=0.518                          |
|POLY 3             |        P=0.404          (e)              P=0.252          (e)              P=0.501                          |
|POLY 1.5           |        P=0.402          (e)              P=0.246          (e)              P=0.498                          |
|POLY 6             |        P=0.407          (e)              P=0.261          (e)              P=0.504                          |
|LOGISTIC REGRESSION|        P=0.535          (e)              P=0.284          (e)              P=0.500                          |
|COCH-ARM / FISHERS |        P=0.408          (e)              P=0.247          (e)              P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.3%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              85               647              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.582N         (e)              P=0.238          P=0.523          (e)                              |
|POLY 3             |        P=0.560N         (e)              P=0.256          P=0.519          (e)                              |
|POLY 1.5           |        P=0.577N         (e)              P=0.247          P=0.510          (e)                              |
|POLY 6             |        P=0.534N         (e)              P=0.271          P=0.533          (e)                              |
|LOGISTIC REGRESSION|        P=0.526          (e)              (e)              P=0.403          (e)                              |
|COCH-ARM / FISHERS |        P=0.598N         (e)              P=0.247          P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        9/49 (18%)       7/50 (14%)       4/49 (8%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        7.3%             20.5%            16.2%            9.2%             4.9%                             |
|TERMINAL (d)       |        2/22 (9%)        5/23 (22%)       3/22 (14%)       2/25 (8%)        2/22 (9%)                        |
|FIRST INCIDENCE    |        565              597              643              628              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.096N         P=0.087          P=0.196          P=0.567          P=0.498N                         |
|POLY 3             |        P=0.092N         P=0.072          P=0.175          P=0.527          P=0.507N                         |
|POLY 1.5           |        P=0.094N         P=0.064          P=0.166          P=0.508          P=0.508N                         |
|POLY 6             |        P=0.089N         P=0.085          P=0.192          P=0.556          P=0.505N                         |
|LOGISTIC REGRESSION|        P=0.095N         P=0.068          P=0.176          P=0.490          P=0.500N                         |
|COCH-ARM / FISHERS |        P=0.091N         P=0.056          P=0.159          P=0.489          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/49 (6%)        3/46 (7%)        4/48 (8%)        2/49 (4%)        1/48 (2%)                        |
|POLY-3 ADJUSTED (b)|        7.0%             6.9%             9.3%             4.3%             2.1%                             |
|TERMINAL (d)       |        1/23 (4%)        3/39 (8%)        3/34 (9%)        2/37 (5%)        0/38 (0%)                        |
|FIRST INCIDENCE    |        689              730 (T)          723              730 (T)          536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.094N         P=0.443N         P=0.615N         P=0.319N         P=0.198N                         |
|POLY 3             |        P=0.132N         P=0.655N         P=0.503          P=0.467N         P=0.275N                         |
|POLY 1.5           |        P=0.143N         P=0.652          P=0.491          P=0.482N         P=0.292N                         |
|POLY 6             |        P=0.116N         P=0.624N         P=0.528          P=0.441N         P=0.248N                         |
|LOGISTIC REGRESSION|        P=0.149N         P=0.608N         P=0.564          P=0.429N         P=0.394N                         |
|COCH-ARM / FISHERS |        P=0.157N         P=0.631          P=0.488          P=0.500N         P=0.316N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/49 (2%)        2/50 (4%)        5/49 (10%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             2.3%             4.6%             11.7%            7.3%                             |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        0/22 (0%)        3/25 (12%)       1/22 (5%)                        |
|FIRST INCIDENCE    |        648              729 (T)          603              690              607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.124          P=0.738N         P=0.523          P=0.152          P=0.322                          |
|POLY 3             |        P=0.114          P=0.750N         P=0.518          P=0.111          P=0.306                          |
|POLY 1.5           |        P=0.116          P=0.757N         P=0.509          P=0.104          P=0.302                          |
|POLY 6             |        P=0.112          P=0.742N         P=0.530          P=0.122          P=0.312                          |
|LOGISTIC REGRESSION|        P=0.119          P=0.764N         P=0.493          P=0.123          P=0.305                          |
|COCH-ARM / FISHERS |        P=0.127          P=0.747          P=0.500          P=0.098          P=0.309                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/49 (4%)        1/46 (2%)        2/48 (4%)        0/49 (0%)        0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.7%             2.3%             4.6%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/39 (0%)        0/34 (0%)        0/37 (0%)        0/38 (0%)                        |
|FIRST INCIDENCE    |        702              645              571              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.083N         P=0.408N         P=0.624N         P=0.166N         P=0.146N                         |
|POLY 3             |        P=0.097N         P=0.491N         P=0.685N         P=0.221N         P=0.220N                         |
|POLY 1.5           |        P=0.099N         P=0.506N         P=0.691          P=0.228N         P=0.231N                         |
|POLY 6             |        P=0.095N         P=0.465N         P=0.664N         P=0.208N         P=0.204N                         |
|LOGISTIC REGRESSION|        P=0.113N         P=0.559N         P=0.692N         P=0.216N         P=0.221N                         |
|COCH-ARM / FISHERS |        P=0.102N         P=0.524N         P=0.684          P=0.247N         P=0.253N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        10/49 (20%)      9/50 (18%)       9/49 (18%)       5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        9.6%             22.8%            20.6%            20.7%            12.1%                            |
|TERMINAL (d)       |        2/22 (9%)        6/23 (26%)       3/22 (14%)       5/25 (20%)       3/22 (14%)                       |
|FIRST INCIDENCE    |        565              597              603              628              607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.391N         P=0.108          P=0.158          P=0.190          P=0.512                          |
|POLY 3             |        P=0.399N         P=0.086          P=0.133          P=0.131          P=0.495                          |
|POLY 1.5           |        P=0.399N         P=0.077          P=0.124          P=0.119          P=0.491                          |
|POLY 6             |        P=0.398N         P=0.099          P=0.149          P=0.151          P=0.501                          |
|LOGISTIC REGRESSION|        P=0.397N         P=0.081          P=0.124          P=0.123          P=0.496                          |
|COCH-ARM / FISHERS |        P=0.376N         P=0.068          P=0.117          P=0.109          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/49 (10%)       4/46 (9%)        6/48 (13%)       2/49 (4%)        1/48 (2%)                        |
|POLY-3 ADJUSTED (b)|        11.6%            9.1%             13.7%            4.3%             2.1%                             |
|TERMINAL (d)       |        1/23 (4%)        3/39 (8%)        3/34 (9%)        2/37 (5%)        0/38 (0%)                        |
|FIRST INCIDENCE    |        689              645              571              730 (T)          536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.021N*        P=0.275N         P=0.547N         P=0.095N         P=0.043N*                        |
|POLY 3             |        P=0.032N*        P=0.488N         P=0.513          P=0.188N         P=0.083N                         |
|POLY 1.5           |        P=0.036N*        P=0.513N         P=0.493          P=0.201N         P=0.094N                         |
|POLY 6             |        P=0.027N*        P=0.445N         P=0.551          P=0.169N         P=0.069N                         |
|LOGISTIC REGRESSION|        P=0.046N*        P=0.506N         P=0.489          P=0.162N         P=0.149N                         |
|COCH-ARM / FISHERS |        P=0.042N*        P=0.541N         P=0.485          P=0.218N         P=0.107N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/49 (2%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             0.0%             4.7%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/21 (0%)        0/23 (0%)        2/22 (9%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        642              ---              729 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.274N         P=0.471N         P=0.520          P=0.485N         P=0.505N                         |
|POLY 3             |        P=0.278N         P=0.483N         P=0.522          P=0.482N         P=0.497N                         |
|POLY 1.5           |        P=0.278N         P=0.488N         P=0.515          P=0.489N         P=0.498N                         |
|POLY 6             |        P=0.277N         P=0.475N         P=0.534          P=0.473N         P=0.495N                         |
|LOGISTIC REGRESSION|        P=0.277N         P=0.530N         P=0.530          P=0.503N         P=0.488N                         |
|COCH-ARM / FISHERS |        P=0.275N         P=0.495N         P=0.508          P=0.495N         P=0.495N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/49 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/49 (4%)        0/50 (0%)        3/50 (6%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             0.0%             7.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/21 (0%)        0/23 (0%)        3/22 (14%)       0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        562              ---              729 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.134N         P=0.217N         P=0.523          P=0.224N         P=0.243N                         |
|POLY 3             |        P=0.139N         P=0.221N         P=0.523          P=0.220N         P=0.236N                         |
|POLY 1.5           |        P=0.138N         P=0.226N         P=0.516          P=0.227N         P=0.237N                         |
|POLY 6             |        P=0.139N         P=0.214N         P=0.534          P=0.212N         P=0.236N                         |
|LOGISTIC REGRESSION|        P=0.135N         P=0.295N         P=0.509          P=0.224N         P=0.196N                         |
|COCH-ARM / FISHERS |        P=0.136N         P=0.242N         P=0.510          P=0.242N         P=0.242N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/49 (0%)        1/50 (2%)        1/50 (2%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          718              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.348N         P=0.610          P=0.576          (e)              (e)                              |
|POLY 3             |        P=0.386N         P=0.518          P=0.512          (e)              (e)                              |
|POLY 1.5           |        P=0.397N         P=0.511          P=0.506          (e)              (e)                              |
|POLY 6             |        P=0.370N         P=0.531          P=0.523          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.368N         P=0.610          P=0.530          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.408N         P=0.505          P=0.505          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Pelvis and Transitional Epithelium                                                                                       |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.7%             0.0%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        ---              ---              638              ---              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.399          (e)              P=0.260          (e)              P=0.500                          |
|POLY 3             |        P=0.401          (e)              P=0.249          (e)              P=0.500                          |
|POLY 1.5           |        P=0.400          (e)              P=0.243          (e)              P=0.498                          |
|POLY 6             |        P=0.403          (e)              P=0.259          (e)              P=0.502                          |
|LOGISTIC REGRESSION|        P=0.401          (e)              P=0.238          (e)              P=0.500                          |
|COCH-ARM / FISHERS |        P=0.408          (e)              P=0.247          (e)              P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Pelvis and Transitional Epithelium                                                                                       |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        9/50 (18%)       5/50 (10%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             6.8%             20.7%            11.4%            7.3%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        3/22 (14%)       3/26 (12%)       1/22 (5%)                        |
|FIRST INCIDENCE    |        729 (T)          669              648              690              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.474          P=0.339          P=0.018 *        P=0.159          P=0.319                          |
|POLY 3             |        P=0.474          P=0.333          P=0.010 *        P=0.119          P=0.308                          |
|POLY 1.5           |        P=0.469          P=0.320          P=0.009 **       P=0.110          P=0.303                          |
|POLY 6             |        P=0.485          P=0.349          P=0.013 *        P=0.133          P=0.316                          |
|LOGISTIC REGRESSION|        P=0.467          P=0.351          P=0.013 *        P=0.147          P=0.305                          |
|COCH-ARM / FISHERS |        P=0.485          P=0.309          P=0.008 **       P=0.102          P=0.309                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        4/50 (8%)        9/50 (18%)       7/50 (14%)       12/49 (24%)                      |
|POLY-3 ADJUSTED (b)|        0.0%             8.6%             19.8%            14.8%            25.2%                            |
|TERMINAL (d)       |        0/23 (0%)        4/40 (10%)       8/35 (23%)       5/37 (14%)       9/40 (23%)                       |
|FIRST INCIDENCE    |        ---              730 (T)          570              635              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.005 **       P=0.153          P=0.011 *        P=0.036 *        P=0.007 **                       |
|POLY 3             |        P<0.001 **       P=0.071          P=0.002 **       P=0.011 *        P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.066          P=0.002 **       P=0.009 **       P<0.001 **                       |
|POLY 6             |        P=0.002 **       P=0.081          P=0.003 **       P=0.015 *        P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.153          P=0.003 **       P=0.014 *        P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.059          P<0.001 **       P=0.006 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.3%             0.0%             2.1%             4.2%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        0/35 (0%)        0/37 (0%)        2/40 (5%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              611              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.284          P=0.367          (e)              P=0.517          P=0.367                          |
|POLY 3             |        P=0.242          P=0.255          (e)              P=0.519          P=0.259                          |
|POLY 1.5           |        P=0.228          P=0.246          (e)              P=0.510          P=0.246                          |
|POLY 6             |        P=0.266          P=0.271          (e)              P=0.534          P=0.281                          |
|LOGISTIC REGRESSION|        P=0.210          P=0.367          (e)              P=0.354          P=0.367                          |
|COCH-ARM / FISHERS |        P=0.211          P=0.247          (e)              P=0.500          P=0.242                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        9/50 (18%)       5/50 (10%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             6.8%             20.7%            11.4%            7.3%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        3/22 (14%)       3/26 (12%)       1/22 (5%)                        |
|FIRST INCIDENCE    |        729 (T)          669              648              690              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.474          P=0.339          P=0.018 *        P=0.159          P=0.319                          |
|POLY 3             |        P=0.474          P=0.333          P=0.010 *        P=0.119          P=0.308                          |
|POLY 1.5           |        P=0.469          P=0.320          P=0.009 **       P=0.110          P=0.303                          |
|POLY 6             |        P=0.485          P=0.349          P=0.013 *        P=0.133          P=0.316                          |
|LOGISTIC REGRESSION|        P=0.467          P=0.351          P=0.013 *        P=0.147          P=0.305                          |
|COCH-ARM / FISHERS |        P=0.485          P=0.309          P=0.008 **       P=0.102          P=0.309                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        6/50 (12%)       9/50 (18%)       8/50 (16%)       14/49 (29%)                      |
|POLY-3 ADJUSTED (b)|        0.0%             12.9%            19.8%            16.7%            29.5%                            |
|TERMINAL (d)       |        0/23 (0%)        6/40 (15%)       8/35 (23%)       5/37 (14%)       11/40 (28%)                      |
|FIRST INCIDENCE    |        ---              730 (T)          570              611              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.003 **       P=0.067          P=0.011 *        P=0.022 *        P=0.003 **                       |
|POLY 3             |        P<0.001 **       P=0.020 *        P=0.002 **       P=0.006 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.018 *        P=0.002 **       P=0.005 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P=0.024 *        P=0.003 **       P=0.008 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.067          P=0.003 **       P=0.004 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.013 *        P<0.001 **       P=0.003 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        4/50 (8%)        4/50 (8%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             6.9%             9.4%             9.1%             4.9%                             |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       4/22 (18%)       4/26 (15%)       2/22 (9%)                        |
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          729 (T)          729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.545          P=0.318          P=0.174          P=0.229          P=0.500                          |
|POLY 3             |        P=0.518          P=0.330          P=0.192          P=0.200          P=0.499                          |
|POLY 1.5           |        P=0.518          P=0.319          P=0.185          P=0.190          P=0.496                          |
|POLY 6             |        P=0.519          P=0.345          P=0.203          P=0.217          P=0.504                          |
|LOGISTIC REGRESSION|        P=0.545          P=0.318          P=0.174          P=0.229          P=0.500                          |
|COCH-ARM / FISHERS |        P=0.534          P=0.309          P=0.181          P=0.181          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        6/50 (12%)       4/50 (8%)        3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.3%             13.3%            8.5%             6.4%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        5/35 (14%)       3/37 (8%)        3/40 (8%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          676              723              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.397          P=0.367          P=0.048 *        P=0.143          P=0.234                          |
|POLY 3             |        P=0.298          P=0.255          P=0.018 *        P=0.072          P=0.136                          |
|POLY 1.5           |        P=0.267          P=0.246          P=0.016 *        P=0.067          P=0.126                          |
|POLY 6             |        P=0.351          P=0.271          P=0.022 *        P=0.083          P=0.156                          |
|LOGISTIC REGRESSION|        P=0.362          P=0.367          P=0.027 *        P=0.121          P=0.234                          |
|COCH-ARM / FISHERS |        P=0.236          P=0.247          P=0.013 *        P=0.059          P=0.117                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        4/50 (8%)        5/50 (10%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             6.9%             9.4%             11.4%            7.3%                             |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       4/22 (18%)       5/26 (19%)       2/22 (9%)                        |
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          729 (T)          607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.322          P=0.318          P=0.174          P=0.139          P=0.310                          |
|POLY 3             |        P=0.310          P=0.330          P=0.192          P=0.118          P=0.307                          |
|POLY 1.5           |        P=0.308          P=0.319          P=0.185          P=0.110          P=0.303                          |
|POLY 6             |        P=0.314          P=0.345          P=0.203          P=0.130          P=0.314                          |
|LOGISTIC REGRESSION|        P=0.292          P=0.318          P=0.174          P=0.139          P=0.306                          |
|COCH-ARM / FISHERS |        P=0.321          P=0.309          P=0.181          P=0.102          P=0.309                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        6/50 (12%)       4/50 (8%)        3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             4.3%             13.3%            8.5%             6.4%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        5/35 (14%)       3/37 (8%)        3/40 (8%)                        |
|FIRST INCIDENCE    |        571              730 (T)          676              723              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.508          P=0.626          P=0.126          P=0.315          P=0.458                          |
|POLY 3             |        P=0.398          P=0.523          P=0.062          P=0.203          P=0.335                          |
|POLY 1.5           |        P=0.368          P=0.511          P=0.057          P=0.192          P=0.317                          |
|POLY 6             |        P=0.448          P=0.543          P=0.071          P=0.223          P=0.367                          |
|LOGISTIC REGRESSION|        P=0.392          P=0.457          P=0.060          P=0.156          P=0.247                          |
|COCH-ARM / FISHERS |        P=0.336          P=0.500          P=0.056          P=0.181          P=0.301                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        4/50 (8%)        5/50 (10%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             6.9%             9.4%             11.4%            7.3%                             |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       4/22 (18%)       5/26 (19%)       2/22 (9%)                        |
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          729 (T)          607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.322          P=0.318          P=0.174          P=0.139          P=0.310                          |
|POLY 3             |        P=0.310          P=0.330          P=0.192          P=0.118          P=0.307                          |
|POLY 1.5           |        P=0.308          P=0.319          P=0.185          P=0.110          P=0.303                          |
|POLY 6             |        P=0.314          P=0.345          P=0.203          P=0.130          P=0.314                          |
|LOGISTIC REGRESSION|        P=0.292          P=0.318          P=0.174          P=0.139          P=0.306                          |
|COCH-ARM / FISHERS |        P=0.321          P=0.309          P=0.181          P=0.102          P=0.309                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        6/50 (12%)       4/50 (8%)        3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             4.3%             13.3%            8.5%             6.4%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        5/35 (14%)       3/37 (8%)        3/40 (8%)                        |
|FIRST INCIDENCE    |        571              730 (T)          676              723              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.508          P=0.626          P=0.126          P=0.315          P=0.458                          |
|POLY 3             |        P=0.398          P=0.523          P=0.062          P=0.203          P=0.335                          |
|POLY 1.5           |        P=0.368          P=0.511          P=0.057          P=0.192          P=0.317                          |
|POLY 6             |        P=0.448          P=0.543          P=0.071          P=0.223          P=0.367                          |
|LOGISTIC REGRESSION|        P=0.392          P=0.457          P=0.060          P=0.156          P=0.247                          |
|COCH-ARM / FISHERS |        P=0.336          P=0.500          P=0.056          P=0.181          P=0.301                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)        2/50 (4%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             4.6%             0.0%             4.6%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        2/23 (9%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        665              729 (T)          ---              719              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.180N         P=0.670N         P=0.230N         P=0.629N         P=0.233N                         |
|POLY 3             |        P=0.192N         P=0.671N         P=0.228N         P=0.670N         P=0.238N                         |
|POLY 1.5           |        P=0.191N         P=0.681N         P=0.233N         P=0.682N         P=0.240N                         |
|POLY 6             |        P=0.194N         P=0.659N         P=0.221N         P=0.653N         P=0.236N                         |
|LOGISTIC REGRESSION|        P=0.185N         P=0.649N         P=0.226N         P=0.648N         P=0.237N                         |
|COCH-ARM / FISHERS |        P=0.185N         P=0.691N         P=0.247N         P=0.691N         P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)        0/50 (0%)        0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.1%             4.4%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        2/35 (6%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              592              730 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.304N         P=0.504          P=0.335          (e)              (e)                              |
|POLY 3             |        P=0.328N         P=0.517          P=0.247          (e)              (e)                              |
|POLY 1.5           |        P=0.342N         P=0.509          P=0.240          (e)              (e)                              |
|POLY 6             |        P=0.306N         P=0.532          P=0.260          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.381N         P=0.484          P=0.335          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.359N         P=0.500          P=0.247          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)        2/50 (4%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             4.6%             0.0%             4.6%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        2/23 (9%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        665              729 (T)          ---              719              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.180N         P=0.670N         P=0.230N         P=0.629N         P=0.233N                         |
|POLY 3             |        P=0.192N         P=0.671N         P=0.228N         P=0.670N         P=0.238N                         |
|POLY 1.5           |        P=0.191N         P=0.681N         P=0.233N         P=0.682N         P=0.240N                         |
|POLY 6             |        P=0.194N         P=0.659N         P=0.221N         P=0.653N         P=0.236N                         |
|LOGISTIC REGRESSION|        P=0.185N         P=0.649N         P=0.226N         P=0.648N         P=0.237N                         |
|COCH-ARM / FISHERS |        P=0.185N         P=0.691N         P=0.247N         P=0.691N         P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        2/50 (4%)        0/50 (0%)        1/48 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             4.2%             4.4%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        2/35 (6%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        605              592              730 (T)          ---              718                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.321N         P=0.533          P=0.594          P=0.487N         P=0.698N                         |
|POLY 3             |        P=0.375N         P=0.528          P=0.512          P=0.484N         P=0.743N                         |
|POLY 1.5           |        P=0.387N         P=0.515          P=0.503          P=0.492N         P=0.755N                         |
|POLY 6             |        P=0.356N         P=0.552          P=0.530          P=0.472N         P=0.721N                         |
|LOGISTIC REGRESSION|        P=0.450N         P=0.423          P=0.500          P=0.653N         P=0.633                          |
|COCH-ARM / FISHERS |        P=0.402N         P=0.500          P=0.500          P=0.500N         P=0.742                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.7%             0.0%             0.0%             2.1%             0.0%                             |
|TERMINAL (d)       |        2/23 (9%)        0/40 (0%)        0/35 (0%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        730 (T)          ---              ---              730 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.209N         P=0.127N         P=0.151N         P=0.336N         P=0.127N                         |
|POLY 3             |        P=0.267N         P=0.220N         P=0.227N         P=0.469N         P=0.213N                         |
|POLY 1.5           |        P=0.264N         P=0.229N         P=0.234N         P=0.483N         P=0.225N                         |
|POLY 6             |        P=0.273N         P=0.206N         P=0.215N         P=0.445N         P=0.195N                         |
|LOGISTIC REGRESSION|        P=0.209N         (e)              (e)              P=0.336N         (e)                              |
|COCH-ARM / FISHERS |        P=0.264N         P=0.247N         P=0.247N         P=0.500N         P=0.247N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)        2/50 (4%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             0.0%             2.2%             4.2%             6.2%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        1/37 (3%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        571              ---              730 (T)          638              712                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.108          P=0.500N         P=0.720N         P=0.565          P=0.449                          |
|POLY 3             |        P=0.079          P=0.487N         P=0.753N         P=0.529          P=0.343                          |
|POLY 1.5           |        P=0.074          P=0.493N         P=0.759N         P=0.516          P=0.325                          |
|POLY 6             |        P=0.087          P=0.475N         P=0.742N         P=0.552          P=0.375                          |
|LOGISTIC REGRESSION|        P=0.057          P=0.483N         P=0.753N         P=0.327          P=0.238                          |
|COCH-ARM / FISHERS |        P=0.068          P=0.500N         P=0.753N         P=0.500          P=0.309                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        0/50 (0%)        1/50 (2%)        3/50 (6%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        6.9%             0.0%             2.2%             6.3%             6.2%                             |
|TERMINAL (d)       |        2/23 (9%)        0/40 (0%)        1/35 (3%)        2/37 (5%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        571              ---              730 (T)          638              712                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.354          P=0.065N         P=0.205N         P=0.504N         P=0.451N                         |
|POLY 3             |        P=0.272          P=0.107N         P=0.293N         P=0.623N         P=0.614N                         |
|POLY 1.5           |        P=0.263          P=0.113N         P=0.303N         P=0.641N         P=0.637N                         |
|POLY 6             |        P=0.287          P=0.098N         P=0.275N         P=0.592N         P=0.573N                         |
|LOGISTIC REGRESSION|        P=0.241          P=0.140N         P=0.305N         P=0.603          P=0.639                          |
|COCH-ARM / FISHERS |        P=0.250          P=0.121N         P=0.309N         P=0.661N         P=0.661N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        5/50 (10%)       1/50 (2%)        8/50 (16%)       4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             11.3%            2.3%             17.9%            9.8%                             |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       1/22 (5%)        2/26 (8%)        3/22 (14%)                       |
|FIRST INCIDENCE    |        729 (T)          477              729 (T)          653              677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.160          P=0.117          P=0.763          P=0.044 *        P=0.184                          |
|POLY 3             |        P=0.143          P=0.122          P=0.750N         P=0.022 *        P=0.178                          |
|POLY 1.5           |        P=0.144          P=0.113          P=0.756N         P=0.019 *        P=0.176                          |
|POLY 6             |        P=0.142          P=0.133          P=0.743N         P=0.029 *        P=0.182                          |
|LOGISTIC REGRESSION|        P=0.148          P=0.104          P=0.763          P=0.023 *        P=0.179                          |
|COCH-ARM / FISHERS |        P=0.161          P=0.102          P=0.753N         P=0.015 *        P=0.181                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/50 (50%)      26/50 (52%)      26/50 (52%)      24/50 (48%)      19/50 (38%)                      |
|POLY-3 ADJUSTED (b)|        54.1%            53.9%            55.6%            49.7%            38.8%                            |
|TERMINAL (d)       |        11/23 (48%)      21/40 (53%)      18/35 (51%)      16/37 (43%)      14/40 (35%)                      |
|FIRST INCIDENCE    |        571              575              571              611              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.007N**       P=0.073N         P=0.162N         P=0.063N         P=0.005N**                       |
|POLY 3             |        P=0.040N*        P=0.575N         P=0.528          P=0.411N         P=0.095N                         |
|POLY 1.5           |        P=0.054N         P=0.548          P=0.495          P=0.452N         P=0.121N                         |
|POLY 6             |        P=0.026N*        P=0.510N         P=0.582N         P=0.349N         P=0.063N                         |
|LOGISTIC REGRESSION|        P=0.056N         P=0.541          P=0.528          P=0.437N         P=0.155N                         |
|COCH-ARM / FISHERS |        P=0.077N         P=0.500          P=0.500          P=0.500N         P=0.157N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        5/50 (10%)       1/50 (2%)        8/50 (16%)       4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             11.3%            2.3%             17.9%            9.8%                             |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       1/22 (5%)        2/26 (8%)        3/22 (14%)                       |
|FIRST INCIDENCE    |        729 (T)          477              729 (T)          653              677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.160          P=0.117          P=0.763          P=0.044 *        P=0.184                          |
|POLY 3             |        P=0.143          P=0.122          P=0.750N         P=0.022 *        P=0.178                          |
|POLY 1.5           |        P=0.144          P=0.113          P=0.756N         P=0.019 *        P=0.176                          |
|POLY 6             |        P=0.142          P=0.133          P=0.743N         P=0.029 *        P=0.182                          |
|LOGISTIC REGRESSION|        P=0.148          P=0.104          P=0.763          P=0.023 *        P=0.179                          |
|COCH-ARM / FISHERS |        P=0.161          P=0.102          P=0.753N         P=0.015 *        P=0.181                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/50 (50%)      26/50 (52%)      26/50 (52%)      25/50 (50%)      19/50 (38%)                      |
|POLY-3 ADJUSTED (b)|        54.1%            53.9%            55.6%            51.8%            38.8%                            |
|TERMINAL (d)       |        11/23 (48%)      21/40 (53%)      18/35 (51%)      17/37 (46%)      14/40 (35%)                      |
|FIRST INCIDENCE    |        571              575              571              611              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.007N**       P=0.073N         P=0.162N         P=0.081N         P=0.005N**                       |
|POLY 3             |        P=0.044N*        P=0.575N         P=0.528          P=0.491N         P=0.095N                         |
|POLY 1.5           |        P=0.059N         P=0.548          P=0.495          P=0.532N         P=0.121N                         |
|POLY 6             |        P=0.028N*        P=0.510N         P=0.582N         P=0.427N         P=0.063N                         |
|LOGISTIC REGRESSION|        P=0.060N         P=0.541          P=0.528          P=0.507N         P=0.155N                         |
|COCH-ARM / FISHERS |        P=0.083N         P=0.500          P=0.500          P=0.579N         P=0.157N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 24
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        5/50 (10%)       1/50 (2%)        8/50 (16%)       4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             11.3%            2.3%             17.9%            9.8%                             |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       1/22 (5%)        2/26 (8%)        3/22 (14%)                       |
|FIRST INCIDENCE    |        729 (T)          477              729 (T)          653              677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.160          P=0.117          P=0.763          P=0.044 *        P=0.184                          |
|POLY 3             |        P=0.143          P=0.122          P=0.750N         P=0.022 *        P=0.178                          |
|POLY 1.5           |        P=0.144          P=0.113          P=0.756N         P=0.019 *        P=0.176                          |
|POLY 6             |        P=0.142          P=0.133          P=0.743N         P=0.029 *        P=0.182                          |
|LOGISTIC REGRESSION|        P=0.148          P=0.104          P=0.763          P=0.023 *        P=0.179                          |
|COCH-ARM / FISHERS |        P=0.161          P=0.102          P=0.753N         P=0.015 *        P=0.181                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        26/50 (52%)      26/50 (52%)      26/50 (52%)      27/50 (54%)      21/50 (42%)                      |
|POLY-3 ADJUSTED (b)|        55.6%            53.9%            55.6%            55.5%            42.8%                            |
|TERMINAL (d)       |        11/23 (48%)      21/40 (53%)      18/35 (51%)      18/37 (49%)      15/40 (38%)                      |
|FIRST INCIDENCE    |        571              575              571              611              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.017N*        P=0.055N         P=0.128N         P=0.107N         P=0.008N**                       |
|POLY 3             |        P=0.102N         P=0.515N         P=0.580N         P=0.578N         P=0.144N                         |
|POLY 1.5           |        P=0.126N         P=0.546N         P=0.563          P=0.546          P=0.174N                         |
|POLY 6             |        P=0.072N         P=0.460N         P=0.534N         P=0.515N         P=0.103N                         |
|LOGISTIC REGRESSION|        P=0.136N         P=0.577N         P=0.565N         P=0.504          P=0.247N                         |
|COCH-ARM / FISHERS |        P=0.163N         P=0.579N         P=0.579N         P=0.500          P=0.212N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 25
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        15/50 (30%)      15/50 (30%)      11/49 (22%)      11/50 (22%)      9/50 (18%)                       |
|POLY-3 ADJUSTED (b)|        34.0%            32.0%            25.6%            24.3%            21.8%                            |
|TERMINAL (d)       |        5/22 (23%)       3/23 (13%)       6/22 (27%)       4/26 (15%)       6/22 (27%)                       |
|FIRST INCIDENCE    |        537              481              620              537              603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.091N         P=0.453N         P=0.224N         P=0.149N         P=0.135N                         |
|POLY 3             |        P=0.100N         P=0.509N         P=0.266N         P=0.216N         P=0.151N                         |
|POLY 1.5           |        P=0.090N         P=0.542N         P=0.269N         P=0.232N         P=0.142N                         |
|POLY 6             |        P=0.117N         P=0.465N         P=0.262N         P=0.198N         P=0.168N                         |
|LOGISTIC REGRESSION|        P=0.071N         P=0.484          P=0.262N         P=0.267N         P=0.124N                         |
|COCH-ARM / FISHERS |        P=0.070N         P=0.586N         P=0.266N         P=0.247N         P=0.121N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        20/50 (40%)      22/50 (44%)      23/50 (46%)      17/49 (35%)      19/49 (39%)                      |
|POLY-3 ADJUSTED (b)|        44.4%            45.0%            50.1%            35.9%            39.5%                            |
|TERMINAL (d)       |        10/23 (44%)      16/40 (40%)      16/35 (46%)      10/36 (28%)      16/40 (40%)                      |
|FIRST INCIDENCE    |        550              513              625              550              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.050N         P=0.156N         P=0.272N         P=0.055N         P=0.034N*                        |
|POLY 3             |        P=0.220N         P=0.559          P=0.369          P=0.264N         P=0.395N                         |
|POLY 1.5           |        P=0.260N         P=0.495          P=0.340          P=0.310N         P=0.458N                         |
|POLY 6             |        P=0.170N         P=0.509N         P=0.432          P=0.201N         P=0.302N                         |
|LOGISTIC REGRESSION|        P=0.256N         P=0.412          P=0.442          P=0.327N         P=0.323N                         |
|COCH-ARM / FISHERS |        P=0.318N         P=0.420          P=0.343          P=0.368N         P=0.532N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 26
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             2.3%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        724              729 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.103N         P=0.476N         P=0.240N         P=0.209N         P=0.244N                         |
|POLY 3             |        P=0.106N         P=0.476N         P=0.227N         P=0.221N         P=0.237N                         |
|POLY 1.5           |        P=0.106N         P=0.486N         P=0.232N         P=0.229N         P=0.239N                         |
|POLY 6             |        P=0.106N         P=0.462N         P=0.219N         P=0.210N         P=0.234N                         |
|LOGISTIC REGRESSION|        P=0.102N         P=0.455N         P=0.210N         P=0.192N         P=0.239N                         |
|COCH-ARM / FISHERS |        P=0.106N         P=0.500N         P=0.247N         P=0.247N         P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.173          (e)              (e)              (e)              P=0.610                          |
|POLY 3             |        P=0.154          (e)              (e)              (e)              P=0.522                          |
|POLY 1.5           |        P=0.150          (e)              (e)              (e)              P=0.512                          |
|POLY 6             |        P=0.160          (e)              (e)              (e)              P=0.540                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.610                          |
|COCH-ARM / FISHERS |        P=0.145          (e)              (e)              (e)              P=0.500                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 27
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             2.3%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        724              729 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.103N         P=0.476N         P=0.240N         P=0.209N         P=0.244N                         |
|POLY 3             |        P=0.106N         P=0.476N         P=0.227N         P=0.221N         P=0.237N                         |
|POLY 1.5           |        P=0.106N         P=0.486N         P=0.232N         P=0.229N         P=0.239N                         |
|POLY 6             |        P=0.106N         P=0.462N         P=0.219N         P=0.210N         P=0.234N                         |
|LOGISTIC REGRESSION|        P=0.102N         P=0.455N         P=0.210N         P=0.192N         P=0.239N                         |
|COCH-ARM / FISHERS |        P=0.106N         P=0.500N         P=0.247N         P=0.247N         P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.173          (e)              (e)              (e)              P=0.610                          |
|POLY 3             |        P=0.154          (e)              (e)              (e)              P=0.522                          |
|POLY 1.5           |        P=0.150          (e)              (e)              (e)              P=0.512                          |
|POLY 6             |        P=0.160          (e)              (e)              (e)              P=0.540                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.610                          |
|COCH-ARM / FISHERS |        P=0.145          (e)              (e)              (e)              P=0.500                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 28
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        3/50 (6%)        2/50 (4%)        7/50 (14%)                       |
|POLY-3 ADJUSTED (b)|        7.3%             6.8%             7.0%             4.6%             17.2%                            |
|TERMINAL (d)       |        1/22 (5%)        2/23 (9%)        2/22 (9%)        1/26 (4%)        5/22 (23%)                       |
|FIRST INCIDENCE    |        562              663              723              719              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.067          P=0.620N         P=0.651N         P=0.434N         P=0.163                          |
|POLY 3             |        P=0.064          P=0.634N         P=0.647N         P=0.473N         P=0.149                          |
|POLY 1.5           |        P=0.066          P=0.646N         P=0.655N         P=0.487N         P=0.149                          |
|POLY 6             |        P=0.063          P=0.617N         P=0.635N         P=0.453N         P=0.149                          |
|LOGISTIC REGRESSION|        P=0.059          P=0.651N         P=0.638N         P=0.482N         P=0.160                          |
|COCH-ARM / FISHERS |        P=0.071          P=0.661N         P=0.661N         P=0.500N         P=0.159                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.465          P=0.610          (e)              (e)              P=0.610                          |
|POLY 3             |        P=0.431          P=0.515          (e)              (e)              P=0.522                          |
|POLY 1.5           |        P=0.419          P=0.508          (e)              (e)              P=0.512                          |
|POLY 6             |        P=0.451          P=0.529          (e)              (e)              P=0.540                          |
|LOGISTIC REGRESSION|        (e)              P=0.610          (e)              (e)              P=0.610                          |
|COCH-ARM / FISHERS |        P=0.404          P=0.500          (e)              (e)              P=0.500                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 29
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       4/50 (8%)        1/50 (2%)        5/50 (10%)       2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        12.2%            9.1%             2.3%             11.1%            4.9%                             |
|TERMINAL (d)       |        3/22 (14%)       2/23 (9%)        1/22 (5%)        2/26 (8%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        677              668              729 (T)          249              680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.257N         P=0.451N         P=0.099N         P=0.519N         P=0.211N                         |
|POLY 3             |        P=0.272N         P=0.455N         P=0.091N         P=0.571N         P=0.214N                         |
|POLY 1.5           |        P=0.271N         P=0.475N         P=0.096N         P=0.596N         P=0.219N                         |
|POLY 6             |        P=0.272N         P=0.429N         P=0.083N         P=0.535N         P=0.205N                         |
|LOGISTIC REGRESSION|        P=0.262N         P=0.415N         P=0.075N         P=0.614          P=0.210N                         |
|COCH-ARM / FISHERS |        P=0.260N         P=0.500N         P=0.102N         P=0.630N         P=0.218N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              703              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.607N         (e)              P=0.557          (e)              (e)                              |
|POLY 3             |        P=0.640N         (e)              P=0.509          (e)              (e)                              |
|POLY 1.5           |        P=0.645N         (e)              P=0.503          (e)              (e)                              |
|POLY 6             |        P=0.632N         (e)              P=0.521          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.652N         (e)              P=0.505          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.649N         (e)              P=0.500          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 30
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       4/50 (8%)        2/50 (4%)        5/50 (10%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        12.2%            9.1%             4.7%             11.1%            7.3%                             |
|TERMINAL (d)       |        3/22 (14%)       2/23 (9%)        1/22 (5%)        2/26 (8%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        677              668              705              249              680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.399N         P=0.451N         P=0.202N         P=0.519N         P=0.349N                         |
|POLY 3             |        P=0.407N         P=0.455N         P=0.197N         P=0.571N         P=0.353N                         |
|POLY 1.5           |        P=0.407N         P=0.475N         P=0.207N         P=0.596N         P=0.360N                         |
|POLY 6             |        P=0.406N         P=0.429N         P=0.183N         P=0.535N         P=0.341N                         |
|LOGISTIC REGRESSION|        P=0.400N         P=0.415N         P=0.169N         P=0.614          P=0.349N                         |
|COCH-ARM / FISHERS |        P=0.394N         P=0.500N         P=0.218N         P=0.630N         P=0.357N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              703              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.607N         (e)              P=0.557          (e)              (e)                              |
|POLY 3             |        P=0.640N         (e)              P=0.509          (e)              (e)                              |
|POLY 1.5           |        P=0.645N         (e)              P=0.503          (e)              (e)                              |
|POLY 6             |        P=0.632N         (e)              P=0.521          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.652N         (e)              P=0.505          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.649N         (e)              P=0.500          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 31
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        3/50 (6%)        2/50 (4%)        5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        0.0%             4.6%             7.0%             4.6%             12.3%                            |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        2/22 (9%)        1/26 (4%)        4/22 (18%)                       |
|FIRST INCIDENCE    |        ---              663              723              719              724                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.026 *        P=0.268          P=0.127          P=0.284          P=0.032 *                        |
|POLY 3             |        P=0.027 *        P=0.254          P=0.127          P=0.253          P=0.029 *                        |
|POLY 1.5           |        P=0.027 *        P=0.247          P=0.123          P=0.245          P=0.029 *                        |
|POLY 6             |        P=0.027 *        P=0.265          P=0.133          P=0.266          P=0.030 *                        |
|LOGISTIC REGRESSION|        P=0.021 *        P=0.249          P=0.137          P=0.282          P=0.028 *                        |
|COCH-ARM / FISHERS |        P=0.029 *        P=0.247          P=0.121          P=0.247          P=0.028 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.455N         P=0.610          (e)              (e)              (e)                              |
|POLY 3             |        P=0.483N         P=0.515          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.490N         P=0.508          (e)              (e)              (e)                              |
|POLY 6             |        P=0.473N         P=0.529          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.610          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.497N         P=0.500          (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 32
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Melanoma Malignant                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        3/50 (6%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             6.8%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        2/26 (8%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              593              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.426          (e)              (e)              P=0.150          (e)                              |
|POLY 3             |        P=0.387          (e)              (e)              P=0.134          (e)                              |
|POLY 1.5           |        P=0.396          (e)              (e)              P=0.126          (e)                              |
|POLY 6             |        P=0.373          (e)              (e)              P=0.145          (e)                              |
|LOGISTIC REGRESSION|        P=0.421          (e)              (e)              P=0.120          (e)                              |
|COCH-ARM / FISHERS |        P=0.423          (e)              (e)              P=0.121          (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Melanoma Malignant                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 33
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             4.9%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        562              ---              ---              ---              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.153          P=0.487N         P=0.491N         P=0.487N         P=0.512                          |
|POLY 3             |        P=0.149          P=0.489N         P=0.493N         P=0.488N         P=0.496                          |
|POLY 1.5           |        P=0.150          P=0.494N         P=0.497N         P=0.494N         P=0.494                          |
|POLY 6             |        P=0.146          P=0.482N         P=0.488N         P=0.480N         P=0.499                          |
|LOGISTIC REGRESSION|        P=0.165          P=0.566N         P=0.461N         P=0.467N         P=0.504                          |
|COCH-ARM / FISHERS |        P=0.155          P=0.500N         P=0.500N         P=0.500N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 34
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        3/50 (6%)        2/50 (4%)        7/50 (14%)                       |
|POLY-3 ADJUSTED (b)|        2.4%             4.6%             7.0%             4.6%             17.2%                            |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        2/22 (9%)        1/26 (4%)        5/22 (23%)                       |
|FIRST INCIDENCE    |        562              663              723              719              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.008 **       P=0.537          P=0.318          P=0.552          P=0.035 *                        |
|POLY 3             |        P=0.008 **       P=0.522          P=0.317          P=0.521          P=0.027 *                        |
|POLY 1.5           |        P=0.008 **       P=0.512          P=0.311          P=0.510          P=0.028 *                        |
|POLY 6             |        P=0.007 **       P=0.535          P=0.327          P=0.536          P=0.027 *                        |
|LOGISTIC REGRESSION|        P=0.007 **       P=0.453          P=0.310          P=0.491          P=0.032 *                        |
|COCH-ARM / FISHERS |        P=0.009 **       P=0.500          P=0.309          P=0.500          P=0.030 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.455N         P=0.610          (e)              (e)              (e)                              |
|POLY 3             |        P=0.483N         P=0.515          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.490N         P=0.508          (e)              (e)              (e)                              |
|POLY 6             |        P=0.473N         P=0.529          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.610          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.497N         P=0.500          (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 35
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        3/50 (6%)        2/50 (4%)        7/50 (14%)                       |
|POLY-3 ADJUSTED (b)|        2.4%             4.6%             7.0%             4.6%             17.2%                            |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        2/22 (9%)        1/26 (4%)        5/22 (23%)                       |
|FIRST INCIDENCE    |        562              663              723              719              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.008 **       P=0.537          P=0.318          P=0.552          P=0.035 *                        |
|POLY 3             |        P=0.008 **       P=0.522          P=0.317          P=0.521          P=0.027 *                        |
|POLY 1.5           |        P=0.008 **       P=0.512          P=0.311          P=0.510          P=0.028 *                        |
|POLY 6             |        P=0.007 **       P=0.535          P=0.327          P=0.536          P=0.027 *                        |
|LOGISTIC REGRESSION|        P=0.007 **       P=0.453          P=0.310          P=0.491          P=0.032 *                        |
|COCH-ARM / FISHERS |        P=0.009 **       P=0.500          P=0.309          P=0.500          P=0.030 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.455N         P=0.610          (e)              (e)              (e)                              |
|POLY 3             |        P=0.483N         P=0.515          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.490N         P=0.508          (e)              (e)              (e)                              |
|POLY 6             |        P=0.473N         P=0.529          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.610          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.497N         P=0.500          (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 36
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        46/50 (92%)      46/50 (92%)      47/50 (94%)      47/50 (94%)      48/50 (96%)                      |
|POLY-3 ADJUSTED (b)|        95.8%            94.8%            98.0%            97.0%            98.2%                            |
|TERMINAL (d)       |        22/22 (100%)     23/23 (100%)     22/22 (100%)     25/26 (96%)      22/22 (100%)                     |
|FIRST INCIDENCE    |        485              477              561              583              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.381          P=0.323N         P=0.469N         P=0.195N         P=0.480                          |
|POLY 3             |        P=0.248          P=0.627N         P=0.483          P=0.605          P=0.450                          |
|POLY 1.5           |        P=0.162          P=0.637N         P=0.448          P=0.500          P=0.303                          |
|POLY 6             |        P=0.471          P=0.618N         P=0.699          P=0.788N         P=0.749                          |
|LOGISTIC REGRESSION|        P=0.068          P=0.431N         P=0.623          P=0.672N         P=0.174                          |
|COCH-ARM / FISHERS |        P=0.231          P=0.643N         P=0.500          P=0.500          P=0.339                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 37
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        6/50 (12%)       6/48 (13%)       7/50 (14%)       4/47 (9%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             13.6%            14.2%            16.0%            10.4%                            |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       1/22 (5%)        5/26 (19%)       4/22 (18%)                       |
|FIRST INCIDENCE    |        687              674              561              690              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.475          P=0.170          P=0.175          P=0.139          P=0.338                          |
|POLY 3             |        P=0.403          P=0.159          P=0.143          P=0.095          P=0.307                          |
|POLY 1.5           |        P=0.404          P=0.147          P=0.131          P=0.087          P=0.303                          |
|POLY 6             |        P=0.403          P=0.176          P=0.162          P=0.108          P=0.313                          |
|LOGISTIC REGRESSION|        P=0.414          P=0.164          P=0.120          P=0.127          P=0.325                          |
|COCH-ARM / FISHERS |        P=0.427          P=0.134          P=0.121          P=0.080          P=0.310                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       4/50 (8%)        5/50 (10%)       10/50 (20%)      9/49 (18%)                       |
|POLY-3 ADJUSTED (b)|        11.5%            8.6%             11.0%            21.2%            18.8%                            |
|TERMINAL (d)       |        4/23 (17%)       4/40 (10%)       3/35 (9%)        8/37 (22%)       9/40 (23%)                       |
|FIRST INCIDENCE    |        550              730 (T)          638              689              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.157          P=0.218N         P=0.409N         P=0.400          P=0.559                          |
|POLY 3             |        P=0.068          P=0.460N         P=0.606N         P=0.168          P=0.248                          |
|POLY 1.5           |        P=0.057          P=0.480N         P=0.624N         P=0.150          P=0.216                          |
|POLY 6             |        P=0.088          P=0.423N         P=0.569N         P=0.204          P=0.305                          |
|LOGISTIC REGRESSION|        P=0.087          P=0.447N         P=0.620N         P=0.191          P=0.290                          |
|COCH-ARM / FISHERS |        P=0.045 *        P=0.500N         P=0.630N         P=0.131          P=0.183                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 38
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/48 (0%)        0/50 (0%)        0/47 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.6%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        2/23 (9%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              729 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.298N         P=0.247          (e)              (e)              (e)                              |
|POLY 3             |        P=0.292N         P=0.253          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.300N         P=0.246          (e)              (e)              (e)                              |
|POLY 6             |        P=0.280N         P=0.262          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.247          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.312N         P=0.247          (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.173          (e)              (e)              (e)              P=0.610                          |
|POLY 3             |        P=0.152          (e)              (e)              (e)              P=0.521                          |
|POLY 1.5           |        P=0.148          (e)              (e)              (e)              P=0.509                          |
|POLY 6             |        P=0.159          (e)              (e)              (e)              P=0.539                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.610                          |
|COCH-ARM / FISHERS |        P=0.142          (e)              (e)              (e)              P=0.495                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 39
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        7/50 (14%)       6/48 (13%)       7/50 (14%)       4/47 (9%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             15.8%            14.2%            16.0%            10.4%                            |
|TERMINAL (d)       |        1/22 (5%)        4/23 (17%)       1/22 (5%)        5/26 (19%)       4/22 (18%)                       |
|FIRST INCIDENCE    |        687              674              561              690              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.536          P=0.107          P=0.175          P=0.139          P=0.338                          |
|POLY 3             |        P=0.465          P=0.098          P=0.143          P=0.095          P=0.307                          |
|POLY 1.5           |        P=0.464          P=0.089          P=0.131          P=0.087          P=0.303                          |
|POLY 6             |        P=0.466          P=0.111          P=0.162          P=0.108          P=0.313                          |
|LOGISTIC REGRESSION|        P=0.474          P=0.106          P=0.120          P=0.127          P=0.325                          |
|COCH-ARM / FISHERS |        P=0.486          P=0.080          P=0.121          P=0.080          P=0.310                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       4/50 (8%)        5/50 (10%)       10/50 (20%)      10/49 (20%)                      |
|POLY-3 ADJUSTED (b)|        11.5%            8.6%             11.0%            21.2%            20.9%                            |
|TERMINAL (d)       |        4/23 (17%)       4/40 (10%)       3/35 (9%)        8/37 (22%)       10/40 (25%)                      |
|FIRST INCIDENCE    |        550              730 (T)          638              689              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.097          P=0.218N         P=0.409N         P=0.400          P=0.471                          |
|POLY 3             |        P=0.036 *        P=0.460N         P=0.606N         P=0.168          P=0.175                          |
|POLY 1.5           |        P=0.029 *        P=0.480N         P=0.624N         P=0.150          P=0.148                          |
|POLY 6             |        P=0.047 *        P=0.423N         P=0.569N         P=0.204          P=0.225                          |
|LOGISTIC REGRESSION|        P=0.049 *        P=0.447N         P=0.620N         P=0.191          P=0.220                          |
|COCH-ARM / FISHERS |        P=0.023 *        P=0.500N         P=0.630N         P=0.131          P=0.122                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 40
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        4/48 (8%)        1/50 (2%)        1/47 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             9.7%             2.3%             2.6%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        2/22 (9%)        1/26 (4%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        674              ---              704              729 (T)          729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.576N         P=0.471N         P=0.214          P=0.719N         P=0.754N                         |
|POLY 3             |        P=0.597N         P=0.487N         P=0.179          P=0.746N         P=0.747                          |
|POLY 1.5           |        P=0.598N         P=0.493N         P=0.172          P=0.753N         P=0.744                          |
|POLY 6             |        P=0.594N         P=0.480N         P=0.190          P=0.735N         P=0.751                          |
|LOGISTIC REGRESSION|        P=0.593N         P=0.508N         P=0.195          P=0.746N         P=0.753                          |
|COCH-ARM / FISHERS |        P=0.588N         P=0.500N         P=0.168          P=0.753N         P=0.737                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        1/23 (4%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        730 (T)          ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.564          P=0.390N         P=0.416N         P=0.405N         P=0.633N                         |
|POLY 3             |        P=0.505          P=0.485N         P=0.491N         P=0.482N         P=0.736N                         |
|POLY 1.5           |        P=0.504          P=0.492N         P=0.497N         P=0.491N         P=0.750N                         |
|POLY 6             |        P=0.504          P=0.471N         P=0.479N         P=0.469N         P=0.714N                         |
|LOGISTIC REGRESSION|        P=0.564          (e)              (e)              (e)              P=0.633N                         |
|COCH-ARM / FISHERS |        P=0.500          P=0.500N         P=0.500N         P=0.500N         P=0.747                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 41
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        0/48 (0%)        1/50 (2%)        0/47 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             6.8%             0.0%             2.3%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        562              477              ---              690              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.167N         P=0.339          P=0.491N         P=0.718N         P=0.500N                         |
|POLY 3             |        P=0.168N         P=0.332          P=0.501N         P=0.747N         P=0.515N                         |
|POLY 1.5           |        P=0.172N         P=0.321          P=0.505N         P=0.754N         P=0.516N                         |
|POLY 6             |        P=0.164N         P=0.347          P=0.495N         P=0.737N         P=0.512N                         |
|LOGISTIC REGRESSION|        P=0.140N         P=0.216          P=0.468N         P=0.762          P=0.456N                         |
|COCH-ARM / FISHERS |        P=0.173N         P=0.309          P=0.510N         P=0.753N         P=0.515N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              730 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.607N         (e)              P=0.584          (e)              (e)                              |
|POLY 3             |        P=0.643N         (e)              P=0.509          (e)              (e)                              |
|POLY 1.5           |        P=0.648N         (e)              P=0.503          (e)              (e)                              |
|POLY 6             |        P=0.635N         (e)              P=0.520          (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.584          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.652N         (e)              P=0.500          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 42
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        3/50 (6%)        4/48 (8%)        2/50 (4%)        1/47 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             6.8%             9.7%             4.6%             2.6%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        2/22 (9%)        1/26 (4%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        562              477              704              690              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.244N         P=0.543          P=0.381          P=0.624N         P=0.493N                         |
|POLY 3             |        P=0.267N         P=0.532          P=0.333          P=0.674N         P=0.527N                         |
|POLY 1.5           |        P=0.267N         P=0.518          P=0.325          P=0.684N         P=0.528N                         |
|POLY 6             |        P=0.264N         P=0.548          P=0.345          P=0.659N         P=0.525N                         |
|LOGISTIC REGRESSION|        P=0.256N         P=0.403          P=0.325          P=0.684          P=0.515N                         |
|COCH-ARM / FISHERS |        P=0.256N         P=0.500          P=0.319          P=0.691N         P=0.523N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             0.0%             2.2%             0.0%             2.1%                             |
|TERMINAL (d)       |        1/23 (4%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        730 (T)          ---              730 (T)          ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.649          P=0.390N         P=0.665N         P=0.405N         P=0.633N                         |
|POLY 3             |        P=0.590          P=0.485N         P=0.751N         P=0.482N         P=0.736N                         |
|POLY 1.5           |        P=0.583          P=0.492N         P=0.758N         P=0.491N         P=0.750N                         |
|POLY 6             |        P=0.599          P=0.471N         P=0.738N         P=0.469N         P=0.714N                         |
|LOGISTIC REGRESSION|        P=0.649          (e)              P=0.665N         (e)              P=0.633N                         |
|COCH-ARM / FISHERS |        P=0.574          P=0.500N         P=0.753N         P=0.500N         P=0.747                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 43
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Carcinoma or Papilloma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        3/50 (6%)        7/50 (14%)       3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             7.0%             15.5%            7.6%                             |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        3/22 (14%)       3/26 (12%)       3/22 (14%)                       |
|FIRST INCIDENCE    |        ---              729 (T)          729 (T)          537              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.069          P=0.509          P=0.118          P=0.017 *        P=0.118                          |
|POLY 3             |        P=0.053          P=0.514          P=0.127          P=0.011 *        P=0.113                          |
|POLY 1.5           |        P=0.055          P=0.508          P=0.123          P=0.009 **       P=0.113                          |
|POLY 6             |        P=0.050          P=0.522          P=0.133          P=0.014 *        P=0.115                          |
|LOGISTIC REGRESSION|        P=0.060          P=0.509          P=0.118          P=0.008 **       P=0.118                          |
|COCH-ARM / FISHERS |        P=0.067          P=0.500          P=0.121          P=0.006 **       P=0.117                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Carcinoma or Papilloma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/49 (0%)        0/49 (0%)        0/49 (0%)        1/50 (2%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.1%             4.2%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        1/37 (3%)        2/40 (5%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.050          (e)              (e)              P=0.595          P=0.367                          |
|POLY 3             |        P=0.037 *        (e)              (e)              P=0.522          P=0.264                          |
|POLY 1.5           |        P=0.035 *        (e)              (e)              P=0.514          P=0.251                          |
|POLY 6             |        P=0.041 *        (e)              (e)              P=0.536          P=0.287                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.595          P=0.367                          |
|COCH-ARM / FISHERS |        P=0.033 *        (e)              (e)              P=0.505          P=0.247                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 44
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        3/50 (6%)        7/50 (14%)       3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             7.0%             15.5%            7.6%                             |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        3/22 (14%)       3/26 (12%)       3/22 (14%)                       |
|FIRST INCIDENCE    |        ---              729 (T)          729 (T)          537              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.069          P=0.509          P=0.118          P=0.017 *        P=0.118                          |
|POLY 3             |        P=0.053          P=0.514          P=0.127          P=0.011 *        P=0.113                          |
|POLY 1.5           |        P=0.055          P=0.508          P=0.123          P=0.009 **       P=0.113                          |
|POLY 6             |        P=0.050          P=0.522          P=0.133          P=0.014 *        P=0.115                          |
|LOGISTIC REGRESSION|        P=0.060          P=0.509          P=0.118          P=0.008 **       P=0.118                          |
|COCH-ARM / FISHERS |        P=0.067          P=0.500          P=0.121          P=0.006 **       P=0.117                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/49 (0%)        0/49 (0%)        0/49 (0%)        1/50 (2%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.1%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        1/37 (3%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.201          (e)              (e)              P=0.595          P=0.610                          |
|POLY 3             |        P=0.178          (e)              (e)              P=0.522          P=0.523                          |
|POLY 1.5           |        P=0.170          (e)              (e)              P=0.514          P=0.512                          |
|POLY 6             |        P=0.191          (e)              (e)              P=0.536          P=0.541                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.595          P=0.610                          |
|COCH-ARM / FISHERS |        P=0.160          (e)              (e)              P=0.505          P=0.500                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 45
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Leiomyosarcoma                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Leiomyosarcoma                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             4.2%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              635              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.544          (e)              (e)              P=0.302          (e)                              |
|POLY 3             |        P=0.545          (e)              (e)              P=0.259          (e)                              |
|POLY 1.5           |        P=0.526          (e)              (e)              P=0.249          (e)                              |
|POLY 6             |        P=0.575          (e)              (e)              P=0.277          (e)                              |
|LOGISTIC REGRESSION|        P=0.485          (e)              (e)              P=0.189          (e)                              |
|COCH-ARM / FISHERS |        P=0.504          (e)              (e)              P=0.247          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 46
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/50 (14%)       9/50 (18%)       9/50 (18%)       4/50 (8%)        5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        15.7%            19.2%            19.9%            8.4%             10.4%                            |
|TERMINAL (d)       |        2/23 (9%)        8/40 (20%)       8/35 (23%)       3/37 (8%)        3/40 (8%)                        |
|FIRST INCIDENCE    |        605              592              655              638              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.051N         P=0.506N         P=0.574N         P=0.137N         P=0.164N                         |
|POLY 3             |        P=0.104N         P=0.437          P=0.405          P=0.226N         P=0.323N                         |
|POLY 1.5           |        P=0.118N         P=0.416          P=0.391          P=0.243N         P=0.350N                         |
|POLY 6             |        P=0.085N         P=0.475          P=0.434          P=0.202N         P=0.281N                         |
|LOGISTIC REGRESSION|        P=0.127N         P=0.365          P=0.400          P=0.365N         P=0.472N                         |
|COCH-ARM / FISHERS |        P=0.136N         P=0.393          P=0.393          P=0.262N         P=0.380N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 47
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/50 (14%)       9/50 (18%)       9/50 (18%)       4/50 (8%)        5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        15.7%            19.2%            19.9%            8.4%             10.4%                            |
|TERMINAL (d)       |        2/23 (9%)        8/40 (20%)       8/35 (23%)       3/37 (8%)        3/40 (8%)                        |
|FIRST INCIDENCE    |        605              592              655              638              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.051N         P=0.506N         P=0.574N         P=0.137N         P=0.164N                         |
|POLY 3             |        P=0.104N         P=0.437          P=0.405          P=0.226N         P=0.323N                         |
|POLY 1.5           |        P=0.118N         P=0.416          P=0.391          P=0.243N         P=0.350N                         |
|POLY 6             |        P=0.085N         P=0.475          P=0.434          P=0.202N         P=0.281N                         |
|LOGISTIC REGRESSION|        P=0.127N         P=0.365          P=0.400          P=0.365N         P=0.472N                         |
|COCH-ARM / FISHERS |        P=0.136N         P=0.393          P=0.393          P=0.262N         P=0.380N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 48
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.6%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              477              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.528N         (e)              P=0.249          (e)              (e)                              |
|POLY 3             |        P=0.510N         (e)              P=0.253          (e)              (e)                              |
|POLY 1.5           |        P=0.515N         (e)              P=0.245          (e)              (e)                              |
|POLY 6             |        P=0.502N         (e)              P=0.264          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.395N         (e)              P=0.260          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.516N         (e)              P=0.247          (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             2.1%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        676              589              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.206N         P=0.733N         P=0.468N         P=0.459N         P=0.437N                         |
|POLY 3             |        P=0.221N         P=0.742N         P=0.492N         P=0.483N         P=0.479N                         |
|POLY 1.5           |        P=0.221N         P=0.751N         P=0.498N         P=0.491N         P=0.489N                         |
|POLY 6             |        P=0.221N         P=0.726N         P=0.481N         P=0.471N         P=0.462N                         |
|LOGISTIC REGRESSION|        P=0.241N         P=0.722          P=0.498N         P=0.550N         P=0.542N                         |
|COCH-ARM / FISHERS |        P=0.222N         P=0.753N         P=0.500N         P=0.500N         P=0.500N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 49
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/50 (50%)      2/50 (4%)        1/50 (2%)        5/50 (10%)       7/50 (14%)                       |
|POLY-3 ADJUSTED (b)|        56.4%            4.5%             2.3%             11.4%            16.7%                            |
|TERMINAL (d)       |        12/22 (55%)      0/23 (0%)        0/22 (0%)        3/26 (12%)       3/22 (14%)                       |
|FIRST INCIDENCE    |        499              668              705              674              607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.011N*        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|POLY 3             |        P=0.003N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|POLY 1.5           |        P=0.004N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|POLY 6             |        P=0.003N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|LOGISTIC REGRESSION|        P=0.010N*        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|COCH-ARM / FISHERS |        P=0.009N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        18/50 (36%)      1/50 (2%)        1/50 (2%)        2/50 (4%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        38.0%            2.2%             2.2%             4.2%             0.0%                             |
|TERMINAL (d)       |        2/23 (9%)        1/40 (3%)        1/35 (3%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        571              730 (T)          730 (T)          634              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|POLY 3             |        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|POLY 1.5           |        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|POLY 6             |        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|LOGISTIC REGRESSION|        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**       P<0.001N**                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 50
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        4/50 (8%)        5/50 (10%)       4/50 (8%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        9.7%             9.0%             11.5%            9.0%             0.0%                             |
|TERMINAL (d)       |        2/22 (9%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        617              645              603              593              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.051N         P=0.570N         P=0.556          P=0.558N         P=0.066N                         |
|POLY 3             |        P=0.053N         P=0.601N         P=0.533          P=0.602N         P=0.062N                         |
|POLY 1.5           |        P=0.052N         P=0.620N         P=0.516          P=0.622N         P=0.062N                         |
|POLY 6             |        P=0.055N         P=0.576N         P=0.559          P=0.573N         P=0.061N                         |
|LOGISTIC REGRESSION|        P=0.043N*        P=0.618          P=0.499          P=0.634          P=0.064N                         |
|COCH-ARM / FISHERS |        P=0.047N*        P=0.643N         P=0.500          P=0.643N         P=0.059N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 51
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        4/50 (8%)        5/50 (10%)       4/50 (8%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        9.7%             9.0%             11.5%            9.0%             0.0%                             |
|TERMINAL (d)       |        2/22 (9%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        617              645              603              593              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.051N         P=0.570N         P=0.556          P=0.558N         P=0.066N                         |
|POLY 3             |        P=0.053N         P=0.601N         P=0.533          P=0.602N         P=0.062N                         |
|POLY 1.5           |        P=0.052N         P=0.620N         P=0.516          P=0.622N         P=0.062N                         |
|POLY 6             |        P=0.055N         P=0.576N         P=0.559          P=0.573N         P=0.061N                         |
|LOGISTIC REGRESSION|        P=0.043N*        P=0.618          P=0.499          P=0.634          P=0.064N                         |
|COCH-ARM / FISHERS |        P=0.047N*        P=0.643N         P=0.500          P=0.643N         P=0.059N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 52
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        50/50 (100%)     50/50 (100%)     48/50 (96%)      50/50 (100%)     48/50 (96%)                      |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           99.3%            100.0%           98.2%                            |
|TERMINAL (d)       |        22/22 (100%)     23/23 (100%)     22/22 (100%)     26/26 (100%)     22/22 (100%)                     |
|FIRST INCIDENCE    |        485              477              561              249              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.438N         (e)              P=0.307N         (e)              P=0.412N                         |
|POLY 3             |        P=0.212N         (e)              P=0.985N         (e)              P=0.549N                         |
|POLY 1.5           |        P=0.251N         (e)              P=0.619N         (e)              P=0.511N                         |
|POLY 6             |        P=0.205N         (e)              P=1.000N         (e)              P=0.608N                         |
|LOGISTIC REGRESSION|        P=0.440N         (e)              (e)              (e)              P=0.437N                         |
|COCH-ARM / FISHERS |        P=0.137N         (e)              P=0.247N         (e)              P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        39/50 (78%)      45/50 (90%)      44/50 (88%)      40/50 (80%)      41/50 (82%)                      |
|POLY-3 ADJUSTED (b)|        81.1%            90.6%            92.0%            80.6%            83.2%                            |
|TERMINAL (d)       |        18/23 (78%)      36/40 (90%)      32/35 (91%)      28/37 (76%)      33/40 (83%)                      |
|FIRST INCIDENCE    |        550              513              570              550              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.010N*        P=0.046N*        P=0.130N         P=0.029N*        P=0.006N**                       |
|POLY 3             |        P=0.303N         P=0.137          P=0.090          P=0.575N         P=0.499                          |
|POLY 1.5           |        P=0.346N         P=0.110          P=0.088          P=0.574          P=0.449                          |
|POLY 6             |        P=0.241N         P=0.186          P=0.109          P=0.498N         P=0.581                          |
|LOGISTIC REGRESSION|        P=0.286N         P=0.107          P=0.137          P=0.535          P=0.551                          |
|COCH-ARM / FISHERS |        P=0.409N         P=0.086          P=0.143          P=0.500          P=0.402                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 53
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        30/50 (60%)      14/50 (28%)      15/50 (30%)      18/50 (36%)      14/50 (28%)                      |
|POLY-3 ADJUSTED (b)|        64.8%            30.4%            32.1%            39.8%            31.9%                            |
|TERMINAL (d)       |        13/22 (59%)      3/23 (13%)       3/22 (14%)       9/26 (35%)       4/22 (18%)                       |
|FIRST INCIDENCE    |        485              477              312              593              466                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.045N*        P=0.003N**       P=0.007N**       P=0.007N**       P=0.006N**                       |
|POLY 3             |        P=0.026N*        P<0.001N**       P<0.001N**       P=0.011N*        P<0.001N**                       |
|POLY 1.5           |        P=0.025N*        P<0.001N**       P<0.001N**       P=0.012N*        P<0.001N**                       |
|POLY 6             |        P=0.027N*        P<0.001N**       P<0.001N**       P=0.010N*        P<0.001N**                       |
|LOGISTIC REGRESSION|        P=0.018N*        P=0.002N**       P=0.003N**       P=0.012N*        P<0.001N**                       |
|COCH-ARM / FISHERS |        P=0.022N*        P<0.001N**       P=0.002N**       P=0.014N*        P<0.001N**                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        24/50 (48%)      9/50 (18%)       11/50 (22%)      9/50 (18%)       10/50 (20%)                      |
|POLY-3 ADJUSTED (b)|        50.3%            19.0%            23.0%            18.5%            20.7%                            |
|TERMINAL (d)       |        4/23 (17%)       6/40 (15%)       5/35 (14%)       4/37 (11%)       7/40 (18%)                       |
|FIRST INCIDENCE    |        571              589              85               611              709                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.006N**       P<0.001N**       P=0.003N**       P<0.001N**       P<0.001N**                       |
|POLY 3             |        P=0.013N*        P<0.001N**       P=0.004N**       P<0.001N**       P=0.002N**                       |
|POLY 1.5           |        P=0.015N*        P<0.001N**       P=0.004N**       P<0.001N**       P=0.002N**                       |
|POLY 6             |        P=0.012N*        P<0.001N**       P=0.004N**       P<0.001N**       P<0.001N**                       |
|LOGISTIC REGRESSION|        P=0.062N         P=0.004N**       P=0.009N**       P=0.012N*        P=0.010N*                        |
|COCH-ARM / FISHERS |        P=0.019N*        P<0.001N**       P=0.006N**       P<0.001N**       P=0.003N**                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 54
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        50/50 (100%)     50/50 (100%)     50/50 (100%)     50/50 (100%)     49/50 (98%)                      |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           100.0%           100.0%           100.0%                           |
|TERMINAL (d)       |        22/22 (100%)     23/23 (100%)     22/22 (100%)     26/26 (100%)     22/22 (100%)                     |
|FIRST INCIDENCE    |        485              477              312              249              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.480N         (e)              (e)              (e)              P=0.467N                         |
|POLY 3             |        P=1.000N         (e)              (e)              (e)              P=1.000N                         |
|POLY 1.5           |        P=1.000N         (e)              (e)              (e)              P=1.000N                         |
|POLY 6             |        P=1.000N         (e)              (e)              (e)              P=1.000N                         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.145N         (e)              (e)              (e)              P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        46/50 (92%)      46/50 (92%)      47/50 (94%)      42/50 (84%)      45/50 (90%)                      |
|POLY-3 ADJUSTED (b)|        92.0%            92.0%            94.0%            84.0%            91.3%                            |
|TERMINAL (d)       |        19/23 (83%)      36/40 (90%)      32/35 (91%)      29/37 (78%)      37/40 (93%)                      |
|FIRST INCIDENCE    |        550              513              85               550              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.006N**       P=0.005N**       P=0.047N*        P=0.004N**       P<0.001N**                       |
|POLY 3             |        P=0.360N         P=0.642          P=0.500          P=0.179N         P=0.596N                         |
|POLY 1.5           |        P=0.329N         P=0.642          P=0.500          P=0.179N         P=0.561N                         |
|POLY 6             |        P=0.390N         P=0.642          P=0.500          P=0.179N         P=0.627N                         |
|LOGISTIC REGRESSION|        P=0.369N         (e)              (e)              (e)              P=0.484N                         |
|COCH-ARM / FISHERS |        P=0.276N         P=0.643N         P=0.500          P=0.178N         P=0.500N                         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).