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TDMS Study 88036-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                       ANTHRAQUINONE                                     DATE: 02/25/99       
EXPERIMENT: 88036 TEST: 03                                                                                     TIME: 11:51:59       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-25337                              ROUTE: DOSED FEED                                              NTP C#: C88036       
PATHOLOGIST: SINGER, A.                                                                                        CAS: 84-65-1         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        2 YEAR CHRONIC RATS                                                         
                                                                                                                                    

               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                       ANTHRAQUINONE                                     DATE: 02/25/99     
EXPERIMENT: 88036 TEST: 03                                                                                     TIME: 11:51:59     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-25337                              ROUTE: DOSED FEED                                              NTP C#: C88036     
PATHOLOGIST: SINGER, A.                                                                                        CAS: 84-65-1       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  ANTHRAQUINONE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Bone                                   Fibrous Osteodystrophy
                                       Osteomalacia
Bone Marrow                            Hyperplasia
Eye                                    Mineralization
Heart: Atrium                          Thrombosis
Intestine Small, Duodenum              Inflammation
Kidney                                 Accumulation, Hyaline Droplet
                                       Cyst
                                       Mineralization Diffuse
                                       Pigmentation
Kidney: Medulla                        Mineralization
Kidney: Renal Tubule                   Hyperplasia
Kidney: Transitional Epithelium        Hyperplasia
Liver                                  Angiectasis
                                       Basophilic Focus
                                       Degeneration Cystic
                                       Eosinophilic Focus
                                       Inflammation
                                       Mixed Cell Focus
                                       Vacuolization Cytoplasmic
Liver: Centrilobular                   Hypertrophy
Lung                                   Mineralization
Lymph Node, Mandibular                 Ectasia
Mammary Gland                          Hyperplasia
Mesentery: Artery                      Mineralization
Mesentery: Fat                         Necrosis
Nose: Respiratory Epithelium           Inflammation
Pancreas: Artery                       Inflammation
                                       Mineralization
Parathyroid Gland                      Hyperplasia
Pituitary Gland: Pars Distalis         Hyperplasia
Pituitary Gland: Pars Nervosa          Hyperplasia
Preputial Gland                        Inflammation
Skin                                   Inflammation
Spleen                                 Congestion
                                       Fibrosis
                                       Hematopoietic Cell Proliferation
                                       Pigmentation
Spleen: Lymphoid Follicle              Atrophy
Stomach, Forestomach                   Hyperplasia
                                       Mineralization
Stomach, Glandular                     Mineralization
Thymus                                 Atrophy
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                       ANTHRAQUINONE                                     DATE: 02/25/99     
EXPERIMENT: 88036 TEST: 03                                                                                     TIME: 11:51:59     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-25337                              ROUTE: DOSED FEED                                              NTP C#: C88036     
PATHOLOGIST: SINGER, A.                                                                                        CAS: 84-65-1       

Adrenal Cortex                         Degeneration Cystic
                                       Hyperplasia
Adrenal Medulla                        Hyperplasia
Bone                                   Osteopetrosis
Bone Marrow                            Atrophy
                                       Hyperplasia
Clitoral Gland                         Hyperplasia
                                       Inflammation
Heart                                  Inflammation
Intestine Large, Rectum                Parasite Metazoan
Kidney                                 Accumulation, Hyaline Droplet
                                       Nephropathy
                                       Pigmentation
Kidney: Medulla                        Mineralization
Kidney: Renal Tubule                   Hyperplasia
Kidney: Transitional Epithelium        Hyperplasia
Liver                                  Angiectasis
                                       Basophilic Focus
                                       Degeneration Cystic
                                       Eosinophilic Focus
                                       Hematopoietic Cell Proliferation
                                       Inflammation
                                       Mixed Cell Focus
Liver: Bile Duct                       Hyperplasia
Liver: Centrilobular                   Hypertrophy
Lung                                   Inflammation
                                       Pigmentation
Lung: Alveolar Epithelium              Hyperplasia
Mammary Gland                          Cyst
                                       Hyperplasia
Nose                                   Foreign Body
Pancreas                               Atrophy
Pituitary Gland                        Angiectasis
                                       Cyst
Pituitary Gland: Pars Distalis         Hyperplasia
Spleen                                 Congestion
                                       Hematopoietic Cell Proliferation
                                       Pigmentation
Stomach, Forestomach                   Ulcer
Thymus                                 Atrophy
Thyroid Gland: C-Cell                  Hyperplasia
Urinary Bladder                        Inflammation
Urinary Bladder: Transitional Epithelium
                                       Hyperplasia
===============================================================
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/50 (14%)       4/50 (8%)        3/50 (6%)        7/50 (14%)       9/50 (18%)                       |
|POLY-3 ADJUSTED (b)|        16.9%            9.1%             7.0%             15.8%            21.6%                            |
|TERMINAL (d)       |        5/22 (23%)       2/23 (9%)        1/22 (5%)        1/26 (4%)        4/22 (18%)                       |
|FIRST INCIDENCE    |        540              676              638              681              603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.116          P=0.229N         P=0.145N         P=0.455N         P=0.413                          |
|POLY 3             |        P=0.098          P=0.227N         P=0.140N         P=0.561N         P=0.392                          |
|POLY 1.5           |        P=0.100          P=0.242N         P=0.149N         P=0.588N         P=0.384                          |
|POLY 6             |        P=0.097          P=0.208N         P=0.126N         P=0.520N         P=0.409                          |
|LOGISTIC REGRESSION|        P=0.098          P=0.212N         P=0.143N         P=0.552N         P=0.393                          |
|COCH-ARM / FISHERS |        P=0.111          P=0.262N         P=0.159N         P=0.613N         P=0.393                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/50 (12%)       2/50 (4%)        6/50 (12%)       9/50 (18%)       3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        13.8%            4.3%             13.1%            19.1%            6.3%                             |
|TERMINAL (d)       |        5/23 (22%)       1/40 (3%)        3/35 (9%)        7/37 (19%)       2/40 (5%)                        |
|FIRST INCIDENCE    |        571              645              571              701              712                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.262N         P=0.041N*        P=0.392N         P=0.589N         P=0.071N                         |
|POLY 3             |        P=0.398N         P=0.110N         P=0.585N         P=0.346          P=0.203N                         |
|POLY 1.5           |        P=0.425N         P=0.122N         P=0.609N         P=0.319          P=0.226N                         |
|POLY 6             |        P=0.358N         P=0.092N         P=0.540N         P=0.396          P=0.166N                         |
|LOGISTIC REGRESSION|        P=0.435N         P=0.131N         P=0.618N         P=0.420          P=0.206N                         |
|COCH-ARM / FISHERS |        P=0.459N         P=0.134N         P=0.620N         P=0.288          P=0.254N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        2/50 (4%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             4.6%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              699              681              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.576          (e)              P=0.548          P=0.285          (e)                              |
|POLY 3             |        P=0.553          (e)              P=0.510          P=0.254          (e)                              |
|POLY 1.5           |        P=0.559          (e)              P=0.505          P=0.246          (e)                              |
|POLY 6             |        P=0.545          (e)              P=0.518          P=0.267          (e)                              |
|LOGISTIC REGRESSION|        P=0.574          (e)              P=0.511          P=0.258          (e)                              |
|COCH-ARM / FISHERS |        P=0.578          (e)              P=0.500          P=0.247          (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              701              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.675          (e)              (e)              P=0.561          (e)                              |
|POLY 3             |        P=0.671          (e)              (e)              P=0.518          (e)                              |
|POLY 1.5           |        P=0.656          (e)              (e)              P=0.510          (e)                              |
|POLY 6             |        P=0.695          (e)              (e)              P=0.532          (e)                              |
|LOGISTIC REGRESSION|        P=0.638          (e)              (e)              P=0.498          (e)                              |
|COCH-ARM / FISHERS |        P=0.639          (e)              (e)              P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/50 (16%)       10/50 (20%)      8/50 (16%)       13/50 (26%)      6/50 (12%)                       |
|POLY-3 ADJUSTED (b)|        19.4%            22.1%            18.5%            28.8%            14.6%                            |
|TERMINAL (d)       |        5/22 (23%)       3/23 (13%)       4/22 (18%)       8/26 (31%)       3/22 (14%)                       |
|FIRST INCIDENCE    |        642              597              603              583              677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.349N         P=0.495          P=0.559N         P=0.301          P=0.386N                         |
|POLY 3             |        P=0.374N         P=0.486          P=0.566N         P=0.220          P=0.385N                         |
|POLY 1.5           |        P=0.369N         P=0.446          P=0.587N         P=0.190          P=0.394N                         |
|POLY 6             |        P=0.380N         P=0.542          P=0.535N         P=0.268          P=0.371N                         |
|LOGISTIC REGRESSION|        P=0.360N         P=0.449          P=0.531N         P=0.228          P=0.374N                         |
|COCH-ARM / FISHERS |        P=0.339N         P=0.398          P=0.607N         P=0.163          P=0.387N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        13/50 (26%)      12/50 (24%)      17/50 (34%)      17/50 (34%)      3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        29.3%            25.3%            37.6%            36.0%            6.4%                             |
|TERMINAL (d)       |        6/23 (26%)       9/40 (23%)       14/35 (40%)      15/37 (41%)      3/40 (8%)                        |
|FIRST INCIDENCE    |        645              513              703              689              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.129N         P=0.479N         P=0.409N         P<0.001N**                       |
|POLY 3             |        P=0.004N**       P=0.426N         P=0.267          P=0.320          P=0.003N**                       |
|POLY 1.5           |        P=0.006N**       P=0.460N         P=0.251          P=0.290          P=0.005N**                       |
|POLY 6             |        P=0.002N**       P=0.371N         P=0.300          P=0.368          P=0.002N**                       |
|LOGISTIC REGRESSION|        P=0.003N**       P=0.466N         P=0.380          P=0.442          P=0.005N**                       |
|COCH-ARM / FISHERS |        P=0.010N*        P=0.500N         P=0.257          P=0.257          P=0.007N**                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        1/50 (2%)        2/50 (4%)        4/50 (8%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        9.6%             2.3%             4.7%             9.1%             2.5%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        1/22 (5%)        4/26 (15%)       0/22 (0%)                        |
|FIRST INCIDENCE    |        537              729 (T)          687              729 (T)          690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.291N         P=0.160N         P=0.307N         P=0.551N         P=0.175N                         |
|POLY 3             |        P=0.323N         P=0.164N         P=0.325N         P=0.618N         P=0.185N                         |
|POLY 1.5           |        P=0.317N         P=0.171N         P=0.332N         P=0.631N         P=0.185N                         |
|POLY 6             |        P=0.331N         P=0.157N         P=0.314N         P=0.601N         P=0.184N                         |
|LOGISTIC REGRESSION|        P=0.306N         P=0.198N         P=0.343N         P=0.629N         P=0.175N                         |
|COCH-ARM / FISHERS |        P=0.299N         P=0.181N         P=0.339N         P=0.643N         P=0.181N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        1/50 (2%)        7/50 (14%)       5/49 (10%)                       |
|POLY-3 ADJUSTED (b)|        6.9%             2.2%             2.2%             14.8%            10.6%                            |
|TERMINAL (d)       |        2/23 (9%)        1/40 (3%)        1/35 (3%)        6/37 (16%)       5/40 (13%)                       |
|FIRST INCIDENCE    |        617              730 (T)          730 (T)          689              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.128          P=0.173N         P=0.202N         P=0.373          P=0.637                          |
|POLY 3             |        P=0.066          P=0.281N         P=0.292N         P=0.193          P=0.404                          |
|POLY 1.5           |        P=0.059          P=0.293N         P=0.302N         P=0.176          P=0.376                          |
|POLY 6             |        P=0.078          P=0.261N         P=0.274N         P=0.223          P=0.452                          |
|LOGISTIC REGRESSION|        P=0.085          P=0.297N         P=0.298N         P=0.217          P=0.432                          |
|COCH-ARM / FISHERS |        P=0.053          P=0.309N         P=0.309N         P=0.159          P=0.346                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        7.2%             4.6%             0.0%             2.3%             9.7%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        565              710              ---              583              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.239          P=0.438N         P=0.116N         P=0.271N         P=0.512                          |
|POLY 3             |        P=0.247          P=0.476N         P=0.113N         P=0.283N         P=0.498                          |
|POLY 1.5           |        P=0.248          P=0.486N         P=0.116N         P=0.294N         P=0.493                          |
|POLY 6             |        P=0.248          P=0.464N         P=0.109N         P=0.268N         P=0.507                          |
|LOGISTIC REGRESSION|        P=0.271          P=0.521N         P=0.123N         P=0.313N         P=0.505                          |
|COCH-ARM / FISHERS |        P=0.253          P=0.500N         P=0.121N         P=0.309N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        1/50 (2%)        4/50 (8%)        3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             4.3%             2.2%             8.5%             6.4%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        1/35 (3%)        4/37 (11%)       3/40 (8%)                        |
|FIRST INCIDENCE    |        715              730 (T)          730 (T)          730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.274          P=0.673          P=0.673N         P=0.341          P=0.510                          |
|POLY 3             |        P=0.195          P=0.526          P=0.751N         P=0.206          P=0.339                          |
|POLY 1.5           |        P=0.178          P=0.514          P=0.758N         P=0.193          P=0.319                          |
|POLY 6             |        P=0.223          P=0.549          P=0.738N         P=0.229          P=0.373                          |
|LOGISTIC REGRESSION|        P=0.272          P=0.608          P=0.719N         P=0.298          P=0.456                          |
|COCH-ARM / FISHERS |        P=0.159          P=0.500          P=0.753N         P=0.181          P=0.301                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        17/50 (34%)      24/50 (48%)      22/50 (44%)      20/50 (40%)      15/50 (30%)                      |
|POLY-3 ADJUSTED (b)|        40.1%            52.3%            49.8%            43.4%            34.9%                            |
|TERMINAL (d)       |        8/22 (36%)       11/23 (48%)      10/22 (46%)      8/26 (31%)       6/22 (27%)                       |
|FIRST INCIDENCE    |        562              597              648              620              537                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.178N         P=0.248          P=0.306          P=0.541N         P=0.403N                         |
|POLY 3             |        P=0.125N         P=0.168          P=0.239          P=0.460          P=0.389N                         |
|POLY 1.5           |        P=0.140N         P=0.139          P=0.219          P=0.398          P=0.414N                         |
|POLY 6             |        P=0.107N         P=0.218          P=0.275          P=0.555          P=0.355N                         |
|LOGISTIC REGRESSION|        P=0.155N         P=0.190          P=0.299          P=0.438          P=0.418N                         |
|COCH-ARM / FISHERS |        P=0.138N         P=0.111          P=0.206          P=0.339          P=0.415N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/50 (16%)       3/50 (6%)        4/50 (8%)        4/50 (8%)        6/49 (12%)                       |
|POLY-3 ADJUSTED (b)|        18.2%            6.5%             8.9%             8.4%             12.7%                            |
|TERMINAL (d)       |        3/23 (13%)       3/40 (8%)        2/35 (6%)        2/37 (5%)        6/40 (15%)                       |
|FIRST INCIDENCE    |        649              730 (T)          703              635              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.354N         P=0.025N*        P=0.072N         P=0.070N         P=0.110N                         |
|POLY 3             |        P=0.535N         P=0.081N         P=0.162N         P=0.141N         P=0.331N                         |
|POLY 1.5           |        P=0.550N         P=0.090N         P=0.174N         P=0.157N         P=0.365N                         |
|POLY 6             |        P=0.513N         P=0.068N         P=0.142N         P=0.117N         P=0.279N                         |
|LOGISTIC REGRESSION|        P=0.515N         P=0.077N         P=0.155N         P=0.182N         P=0.310N                         |
|COCH-ARM / FISHERS |        P=0.548          P=0.100N         P=0.178N         P=0.178N         P=0.403N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel                                                                                                                     |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        4/50 (8%)        7/50 (14%)       7/50 (14%)                       |
|POLY-3 ADJUSTED (b)|        7.2%             6.8%             9.3%             15.5%            16.7%                            |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        555              676              699              620              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.056          P=0.609N         P=0.557          P=0.255          P=0.188                          |
|POLY 3             |        P=0.051          P=0.637N         P=0.516          P=0.192          P=0.158                          |
|POLY 1.5           |        P=0.051          P=0.648N         P=0.507          P=0.175          P=0.154                          |
|POLY 6             |        P=0.054          P=0.624N         P=0.529          P=0.220          P=0.167                          |
|LOGISTIC REGRESSION|        P=0.055          P=0.644          P=0.507          P=0.143          P=0.159                          |
|COCH-ARM / FISHERS |        P=0.056          P=0.661N         P=0.500          P=0.159          P=0.159                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel                                                                                                                     |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        8/50 (16%)       11/50 (22%)      9/50 (18%)                       |
|POLY-3 ADJUSTED (b)|        4.9%             9.1%             18.2%            24.4%            21.2%                            |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        3/26 (12%)       0/22 (0%)                        |
|FIRST INCIDENCE    |        681              676              565              620              607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.019 *        P=0.407          P=0.078          P=0.030 *        P=0.041 *                        |
|POLY 3             |        P=0.017 *        P=0.371          P=0.056          P=0.011 *        P=0.028 *                        |
|POLY 1.5           |        P=0.015 *        P=0.356          P=0.051          P=0.009 **       P=0.025 *                        |
|POLY 6             |        P=0.020 *        P=0.392          P=0.066          P=0.016 *        P=0.033 *                        |
|LOGISTIC REGRESSION|        P=0.016 *        P=0.380          P=0.051          P=0.011 *        P=0.027 *                        |
|COCH-ARM / FISHERS |        P=0.018 *        P=0.339          P=0.046 *        P=0.007 **       P=0.026 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              730 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.607N         (e)              P=0.584          (e)              (e)                              |
|POLY 3             |        P=0.640N         (e)              P=0.509          (e)              (e)                              |
|POLY 1.5           |        P=0.645N         (e)              P=0.503          (e)              (e)                              |
|POLY 6             |        P=0.633N         (e)              P=0.520          (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.584          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.649N         (e)              P=0.500          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteomalacia                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        13/50 (26%)      12/50 (24%)      8/50 (16%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             28.7%            26.3%            17.9%            7.3%                             |
|TERMINAL (d)       |        0/22 (0%)        4/23 (17%)       0/22 (0%)        2/26 (8%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              615              561              628              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.236N         P<0.001 **       P=0.002 **       P=0.014 *        P=0.137                          |
|POLY 3             |        P=0.192N         P<0.001 **       P<0.001 **       P=0.005 **       P=0.121                          |
|POLY 1.5           |        P=0.206N         P<0.001 **       P<0.001 **       P=0.004 **       P=0.118                          |
|POLY 6             |        P=0.172N         P<0.001 **       P<0.001 **       P=0.007 **       P=0.125                          |
|LOGISTIC REGRESSION|        P=0.210N         P<0.001 **       P<0.001 **       P=0.006 **       P=0.121                          |
|COCH-ARM / FISHERS |        P=0.212N         P<0.001 **       P<0.001 **       P=0.003 **       P=0.121                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteomalacia                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        645              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.363N         P=0.470N         P=0.484N         P=0.480N         P=0.500N                         |
|POLY 3             |        P=0.359N         P=0.487N         P=0.492N         P=0.487N         P=0.502N                         |
|POLY 1.5           |        P=0.358N         P=0.493N         P=0.496N         P=0.494N         P=0.503N                         |
|POLY 6             |        P=0.360N         P=0.481N         P=0.486N         P=0.478N         P=0.501N                         |
|LOGISTIC REGRESSION|        P=0.342N         P=0.531N         P=0.503N         P=0.506N         P=0.492N                         |
|COCH-ARM / FISHERS |        P=0.359N         P=0.500N         P=0.500N         P=0.500N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        3/50 (6%)        1/50 (2%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        7.0%             4.3%             6.7%             2.1%             0.0%                             |
|TERMINAL (d)       |        3/23 (13%)       1/40 (3%)        2/35 (6%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        730 (T)          589              703              730 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.034N*        P=0.303N         P=0.470N         P=0.154N         P=0.043N*                        |
|POLY 3             |        P=0.052N         P=0.460N         P=0.641N         P=0.274N         P=0.100N                         |
|POLY 1.5           |        P=0.056N         P=0.479N         P=0.656N         P=0.289N         P=0.109N                         |
|POLY 6             |        P=0.047N*        P=0.427N         P=0.612N         P=0.251N         P=0.087N                         |
|LOGISTIC REGRESSION|        P=0.053N         P=0.493N         P=0.537N         P=0.154N         (e)                              |
|COCH-ARM / FISHERS |        P=0.061N         P=0.500N         P=0.661N         P=0.309N         P=0.121N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        13/50 (26%)      13/50 (26%)      11/50 (22%)      13/50 (26%)                      |
|POLY-3 ADJUSTED (b)|        9.2%             28.0%            28.5%            23.3%            27.0%                            |
|TERMINAL (d)       |        3/23 (13%)       13/40 (33%)      12/35 (34%)      9/37 (24%)       13/40 (33%)                      |
|FIRST INCIDENCE    |        571              730 (T)          506              675              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.337          P=0.146          P=0.084          P=0.209          P=0.146                          |
|POLY 3             |        P=0.161          P=0.020 *        P=0.018 *        P=0.062          P=0.025 *                        |
|POLY 1.5           |        P=0.131          P=0.017 *        P=0.015 *        P=0.053          P=0.019 *                        |
|POLY 6             |        P=0.221          P=0.027 *        P=0.023 *        P=0.079          P=0.038 *                        |
|LOGISTIC REGRESSION|        P=0.224          P=0.041 *        P=0.020 *        P=0.080          P=0.048 *                        |
|COCH-ARM / FISHERS |        P=0.103          P=0.016 *        P=0.016 *        P=0.045 *        P=0.016 *                        |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             4.6%             0.0%             2.3%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        2/23 (9%)        0/22 (0%)        1/26 (4%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        648              729 (T)          ---              729 (T)          729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.379N         P=0.660N         P=0.228N         P=0.452N         P=0.505N                         |
|POLY 3             |        P=0.382N         P=0.672N         P=0.228N         P=0.478N         P=0.504N                         |
|POLY 1.5           |        P=0.382N         P=0.681N         P=0.233N         P=0.489N         P=0.505N                         |
|POLY 6             |        P=0.381N         P=0.660N         P=0.222N         P=0.462N         P=0.502N                         |
|LOGISTIC REGRESSION|        P=0.385N         P=0.656N         P=0.233N         P=0.473N         P=0.498N                         |
|COCH-ARM / FISHERS |        P=0.378N         P=0.691N         P=0.247N         P=0.500N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/50 (50%)      28/50 (56%)      37/50 (74%)      36/50 (72%)      33/50 (66%)                      |
|POLY-3 ADJUSTED (b)|        55.8%            61.2%            78.2%            74.6%            70.8%                            |
|TERMINAL (d)       |        12/22 (55%)      15/23 (65%)      17/22 (77%)      17/26 (65%)      16/22 (73%)                      |
|FIRST INCIDENCE    |        499              641              477              249              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.128          P=0.517          P=0.075          P=0.230          P=0.149                          |
|POLY 3             |        P=0.091          P=0.373          P=0.013 *        P=0.038 *        P=0.090                          |
|POLY 1.5           |        P=0.081          P=0.360          P=0.011 *        P=0.027 *        P=0.084                          |
|POLY 6             |        P=0.103          P=0.388          P=0.020 *        P=0.062          P=0.098                          |
|LOGISTIC REGRESSION|        P=0.059          P=0.462          P=0.014 *        P=0.023 *        P=0.077                          |
|COCH-ARM / FISHERS |        P=0.071          P=0.344          P=0.011 *        P=0.020 *        P=0.078                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        19/50 (38%)      31/50 (62%)      28/50 (56%)      19/50 (38%)      23/50 (46%)                      |
|POLY-3 ADJUSTED (b)|        41.4%            62.2%            56.4%            39.2%            46.1%                            |
|TERMINAL (d)       |        6/23 (26%)       22/40 (55%)      15/35 (43%)      12/37 (32%)      15/40 (38%)                      |
|FIRST INCIDENCE    |        571              513              85               611              486                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.067N         P=0.398          P=0.393          P=0.160N         P=0.248N                         |
|POLY 3             |        P=0.217N         P=0.030 *        P=0.099          P=0.500N         P=0.398                          |
|POLY 1.5           |        P=0.258N         P=0.020 *        P=0.075          P=0.538N         P=0.338                          |
|POLY 6             |        P=0.165N         P=0.053          P=0.146          P=0.441N         P=0.492                          |
|LOGISTIC REGRESSION|        P=0.536N         P=0.006 **       P=0.035 *        P=0.522          P=0.153                          |
|COCH-ARM / FISHERS |        P=0.317N         P=0.014 *        P=0.054          P=0.582N         P=0.272                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             0.0%             0.0%             2.4%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        499              ---              ---              ---              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.591N         P=0.229N         P=0.242N         P=0.227N         P=0.509N                         |
|POLY 3             |        P=0.581N         P=0.225N         P=0.230N         P=0.225N         P=0.504N                         |
|POLY 1.5           |        P=0.579N         P=0.231N         P=0.234N         P=0.231N         P=0.506N                         |
|POLY 6             |        P=0.584N         P=0.218N         P=0.224N         P=0.215N         P=0.500N                         |
|LOGISTIC REGRESSION|        P=0.518N         P=0.292N         P=0.228N         P=0.231N         P=0.467N                         |
|COCH-ARM / FISHERS |        P=0.577N         P=0.247N         P=0.247N         P=0.247N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             2.2%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        665              730 (T)          638              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.177N         P=0.682N         P=0.744N         P=0.465N         P=0.448N                         |
|POLY 3             |        P=0.201N         P=0.745N         P=0.750N         P=0.483N         P=0.480N                         |
|POLY 1.5           |        P=0.205N         P=0.752N         P=0.757N         P=0.491N         P=0.491N                         |
|POLY 6             |        P=0.195N         P=0.730N         P=0.737N         P=0.471N         P=0.463N                         |
|LOGISTIC REGRESSION|        P=0.226N         P=0.762          P=0.753N         P=0.569N         P=0.612N                         |
|COCH-ARM / FISHERS |        P=0.210N         P=0.753N         P=0.753N         P=0.500N         P=0.505N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/49 (4%)        5/46 (11%)       8/48 (17%)       4/49 (8%)        3/48 (6%)                        |
|POLY-3 ADJUSTED (b)|        4.7%             11.5%            18.6%            8.7%             6.5%                             |
|TERMINAL (d)       |        2/23 (9%)        5/39 (13%)       7/34 (21%)       4/37 (11%)       3/38 (8%)                        |
|FIRST INCIDENCE    |        730 (T)          730 (T)          723              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.245N         P=0.468          P=0.148          P=0.570          P=0.644N                         |
|POLY 3             |        P=0.344N         P=0.224          P=0.046 *        P=0.374          P=0.537                          |
|POLY 1.5           |        P=0.375N         P=0.208          P=0.042 *        P=0.357          P=0.514                          |
|POLY 6             |        P=0.296N         P=0.256          P=0.054          P=0.404          P=0.574                          |
|LOGISTIC REGRESSION|        P=0.237N         P=0.468          P=0.125          P=0.570          P=0.644N                         |
|COCH-ARM / FISHERS |        P=0.411N         P=0.192          P=0.042 *        P=0.339          P=0.490                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/49 (20%)      21/46 (46%)      13/48 (27%)      11/49 (22%)      12/48 (25%)                      |
|POLY-3 ADJUSTED (b)|        23.1%            46.3%            29.3%            23.6%            26.0%                            |
|TERMINAL (d)       |        6/23 (26%)       16/39 (41%)      8/34 (24%)       8/37 (22%)       12/38 (32%)                      |
|FIRST INCIDENCE    |        645              513              571              675              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.080N         P=0.228          P=0.542N         P=0.296N         P=0.297N                         |
|POLY 3             |        P=0.185N         P=0.017 *        P=0.339          P=0.577          P=0.472                          |
|POLY 1.5           |        P=0.216N         P=0.011 *        P=0.309          P=0.541          P=0.429                          |
|POLY 6             |        P=0.144N         P=0.033 *        P=0.399          P=0.563N         P=0.546                          |
|LOGISTIC REGRESSION|        P=0.222N         P=0.009 **       P=0.315          P=0.555N         P=0.533N                         |
|COCH-ARM / FISHERS |        P=0.260N         P=0.008 **       P=0.297          P=0.500          P=0.383                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland: Duct                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland: Duct                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/49 (8%)        5/46 (11%)       2/48 (4%)        4/49 (8%)        3/48 (6%)                        |
|POLY-3 ADJUSTED (b)|        9.3%             11.5%            4.6%             8.7%             6.5%                             |
|TERMINAL (d)       |        3/23 (13%)       5/39 (13%)       2/34 (6%)        4/37 (11%)       3/38 (8%)                        |
|FIRST INCIDENCE    |        649              730 (T)          730 (T)          730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.245N         P=0.485N         P=0.196N         P=0.398N         P=0.264N                         |
|POLY 3             |        P=0.344N         P=0.509          P=0.335N         P=0.603N         P=0.460N                         |
|POLY 1.5           |        P=0.363N         P=0.486          P=0.346N         P=0.622N         P=0.485N                         |
|POLY 6             |        P=0.316N         P=0.552          P=0.313N         P=0.571N         P=0.418N                         |
|LOGISTIC REGRESSION|        P=0.270N         P=0.605          P=0.296N         P=0.532N         P=0.403N                         |
|COCH-ARM / FISHERS |        P=0.387N         P=0.459          P=0.349N         P=0.643N         P=0.512N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        3/50 (6%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             0.0%             6.9%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        0/22 (0%)        3/26 (12%)       0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              729 (T)          ---              729 (T)          705                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.257          P=0.509          (e)              P=0.150          P=0.484                          |
|POLY 3             |        P=0.249          P=0.514          (e)              P=0.132          P=0.500                          |
|POLY 1.5           |        P=0.252          P=0.508          (e)              P=0.125          P=0.498                          |
|POLY 6             |        P=0.246          P=0.522          (e)              P=0.141          P=0.503                          |
|LOGISTIC REGRESSION|        P=0.245          P=0.509          (e)              P=0.150          P=0.502                          |
|COCH-ARM / FISHERS |        P=0.266          P=0.500          (e)              P=0.121          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/2 (100%)       0/0 (0%)         2/4 (50%)        4/5 (80%)        0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        100.0%           0.0%             50.0%            83.5%            0.0%                             |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/2 (0%)         3/3 (100%)       0/0 (0%)                         |
|FIRST INCIDENCE    |        485              ---              663              727              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.338N         (e)              P=0.663N         P=0.445N         P=0.236N                         |
|POLY 3             |        (e)              (e)              P=0.386N         P=0.754N         P=0.128N                         |
|POLY 1.5           |        (e)              (e)              P=0.386N         P=0.712N         P<0.001N**                       |
|POLY 6             |        (e)              (e)              P=0.386N         P=0.838N         P=0.625N                         |
|LOGISTIC REGRESSION|        P=0.128N         (e)              (e)              P=0.780N         P=0.159N                         |
|COCH-ARM / FISHERS |        P=0.111N         (e)              P=0.400N         P=0.714N         P=0.167N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/2 (100%)       3/3 (100%)       1/2 (50%)        2/3 (67%)        3/5 (60%)                        |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           60.0%            69.3%            60.0%                            |
|TERMINAL (d)       |        1/1 (100%)       3/3 (100%)       0/0 (0%)         2/2 (100%)       3/5 (60%)                        |
|FIRST INCIDENCE    |        676              730 (T)          703              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.061N         (e)              P=0.684N         P=0.446N         P=0.267N                         |
|POLY 3             |        P=0.185N         (e)              P=0.645N         P=0.616N         P=0.451N                         |
|POLY 1.5           |        P=0.206N         (e)              P=0.567N         P=0.596N         P=0.451N                         |
|POLY 6             |        P=0.156N         (e)              P=0.822N         P=0.658N         P=0.451N                         |
|LOGISTIC REGRESSION|        P=0.054N         (e)              (e)              P=0.474N         P=0.267N                         |
|COCH-ARM / FISHERS |        P=0.210N         (e)              P=0.500N         P=0.600N         P=0.476N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         0/0 (0%)         0/4 (0%)         1/5 (20%)        0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             20.0%            0.0%                             |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/3 (0%)         0/0 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              674              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.637          (e)              (e)              P=0.531          (e)                              |
|POLY 3             |        (e)              (e)              (e)              P=0.746          (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              P=0.718          (e)                              |
|POLY 6             |        (e)              (e)              (e)              P=0.773          (e)                              |
|LOGISTIC REGRESSION|        P=0.736          (e)              (e)              P=0.780          (e)                              |
|COCH-ARM / FISHERS |        P=0.731          (e)              (e)              P=0.714          (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         0/3 (0%)         1/2 (50%)        2/3 (67%)        2/5 (40%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             52.8%            66.7%            40.0%                            |
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/0 (0%)         1/2 (50%)        2/5 (40%)                        |
|FIRST INCIDENCE    |        ---              ---              638              701              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.290          (e)              P=0.536          P=0.357          P=0.638                          |
|POLY 3             |        P=0.252          (e)              P=0.511          P=0.316          P=0.481                          |
|POLY 1.5           |        P=0.241          (e)              P=0.506          P=0.299          P=0.467                          |
|POLY 6             |        P=0.272          (e)              P=0.520          P=0.348          P=0.506                          |
|LOGISTIC REGRESSION|        P=0.093          (e)              (e)              P=0.297          P=0.638                          |
|COCH-ARM / FISHERS |        P=0.222          (e)              P=0.500          P=0.300          P=0.476                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         0/0 (0%)         0/4 (0%)         2/5 (40%)        0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             41.8%            0.0%                             |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/2 (0%)         2/3 (67%)        0/0 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.662          (e)              (e)              P=1.000N         (e)                              |
|POLY 3             |        (e)              (e)              (e)              P=0.593          (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              P=0.535          (e)                              |
|POLY 6             |        (e)              (e)              (e)              P=0.661          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=1.000N         (e)                              |
|COCH-ARM / FISHERS |        P=0.605          (e)              (e)              P=0.476          (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         0/3 (0%)         0/2 (0%)         0/3 (0%)         1/5 (20%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             20.0%                            |
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/0 (0%)         0/2 (0%)         1/5 (20%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.339          (e)              (e)              (e)              P=0.814                          |
|POLY 3             |        P=0.289          (e)              (e)              (e)              P=0.689                          |
|POLY 1.5           |        P=0.282          (e)              (e)              (e)              P=0.681                          |
|POLY 6             |        P=0.301          (e)              (e)              (e)              P=0.702                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.814                          |
|COCH-ARM / FISHERS |        P=0.248          (e)              (e)              (e)              P=0.714                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         0/0 (0%)         0/4 (0%)         4/5 (80%)        1/2 (50%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             83.5%            77.4%                            |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/2 (0%)         3/3 (100%)       0/0 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              727              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.064          (e)              (e)              P=0.541          P=0.517                          |
|POLY 3             |        (e)              (e)              (e)              P=0.307          P=0.556                          |
|POLY 1.5           |        (e)              (e)              (e)              P=0.192          P=0.520                          |
|POLY 6             |        (e)              (e)              (e)              P=0.498          P=0.665                          |
|LOGISTIC REGRESSION|        P=0.021 *        (e)              (e)              (e)              P=0.450                          |
|COCH-ARM / FISHERS |        P=0.120          (e)              (e)              P=0.143          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         0/3 (0%)         0/2 (0%)         0/3 (0%)         0/5 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/0 (0%)         0/2 (0%)         0/5 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         0/0 (0%)         0/4 (0%)         0/5 (0%)         0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/3 (0%)         0/0 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/2 (0%)         2/3 (67%)        1/2 (50%)        0/3 (0%)         0/5 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             66.7%            60.0%            0.0%             0.0%                             |
|TERMINAL (d)       |        0/1 (0%)         2/3 (67%)        0/0 (0%)         0/2 (0%)         0/5 (0%)                         |
|FIRST INCIDENCE    |        ---              730 (T)          703              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.108N         P=0.500          P=0.589          (e)              (e)                              |
|POLY 3             |        P=0.062N         P=0.316          P=0.484          (e)              (e)                              |
|POLY 1.5           |        P=0.071N         P=0.299          P=0.492          (e)              (e)                              |
|POLY 6             |        P=0.049N*        P=0.348          P=0.471          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.085N         P=0.500          P=0.383          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.118N         P=0.300          P=0.500          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/2 (100%)       0/0 (0%)         3/4 (75%)        4/5 (80%)        1/2 (50%)                        |
|POLY-3 ADJUSTED (b)|        100.0%           0.0%             75.0%            83.5%            77.4%                            |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         1/2 (50%)        3/3 (100%)       0/0 (0%)                         |
|FIRST INCIDENCE    |        485              ---              663              727              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.570N         (e)              P=0.663N         P=0.445N         P=0.487N                         |
|POLY 3             |        (e)              (e)              P=0.631N         P=0.754N         P=0.962N                         |
|POLY 1.5           |        (e)              (e)              P=0.631N         P=0.712N         P=0.736N                         |
|POLY 6             |        (e)              (e)              P=0.631N         P=0.838N         P=1.000N                         |
|LOGISTIC REGRESSION|        P=0.364N         (e)              (e)              P=0.780N         (e)                              |
|COCH-ARM / FISHERS |        P=0.305N         (e)              P=0.667N         P=0.714N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/2 (50%)        3/3 (100%)       2/2 (100%)       1/3 (33%)        3/5 (60%)                        |
|POLY-3 ADJUSTED (b)|        55.7%            100.0%           100.0%           34.7%            60.0%                            |
|TERMINAL (d)       |        1/1 (100%)       3/3 (100%)       0/0 (0%)         1/2 (50%)        3/5 (60%)                        |
|FIRST INCIDENCE    |        730 (T)          730 (T)          638              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.160N         P=1.000N         P=0.311          P=0.638N         P=0.638N                         |
|POLY 3             |        P=0.299N         P=0.503          P=0.577          P=0.660N         P=0.745                          |
|POLY 1.5           |        P=0.323N         P=0.455          P=0.536          P=0.665N         P=0.722                          |
|POLY 6             |        P=0.261N         P=0.618          P=0.669          P=0.650N         P=0.769N                         |
|LOGISTIC REGRESSION|        P=0.289N         P=1.000N         P=0.419          P=0.638N         P=0.638N                         |
|COCH-ARM / FISHERS |        P=0.345N         P=0.400          P=0.500          P=0.700N         P=0.714                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        42/50 (84%)      44/50 (88%)      44/50 (88%)      43/50 (86%)      41/50 (82%)                      |
|POLY-3 ADJUSTED (b)|        85.4%            89.2%            91.6%            88.7%            85.2%                            |
|TERMINAL (d)       |        20/22 (91%)      21/23 (91%)      22/22 (100%)     22/26 (85%)      18/22 (82%)                      |
|FIRST INCIDENCE    |        485              477              477              537              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.405N         P=0.466N         P=0.559          P=0.242N         P=0.470N                         |
|POLY 3             |        P=0.412N         P=0.388          P=0.250          P=0.423          P=0.610N                         |
|POLY 1.5           |        P=0.410N         P=0.388          P=0.291          P=0.429          P=0.599N                         |
|POLY 6             |        P=0.406N         P=0.388          P=0.213          P=0.445          P=0.621N                         |
|LOGISTIC REGRESSION|        P=0.366N         P=0.323          P=0.402          P=0.519          P=0.507N                         |
|COCH-ARM / FISHERS |        P=0.307N         P=0.387          P=0.387          P=0.500          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        22/50 (44%)      25/50 (50%)      27/50 (54%)      28/50 (56%)      28/48 (58%)                      |
|POLY-3 ADJUSTED (b)|        48.3%            53.6%            57.8%            59.1%            58.8%                            |
|TERMINAL (d)       |        13/23 (57%)      24/40 (60%)      19/35 (54%)      25/37 (68%)      24/40 (60%)                      |
|FIRST INCIDENCE    |        550              694              571              635              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.334N         P=0.079N         P=0.352N         P=0.257N         P=0.173N                         |
|POLY 3             |        P=0.201          P=0.380          P=0.237          P=0.198          P=0.208                          |
|POLY 1.5           |        P=0.150          P=0.360          P=0.209          P=0.178          P=0.158                          |
|POLY 6             |        P=0.296          P=0.431          P=0.303          P=0.240          P=0.307                          |
|LOGISTIC REGRESSION|        P=0.290          P=0.556          P=0.243          P=0.344          P=0.182                          |
|COCH-ARM / FISHERS |        P=0.099          P=0.344          P=0.212          P=0.159          P=0.112                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)        2/50 (4%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             2.3%             4.5%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              729 (T)          638              628              724                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.368          P=0.509          P=0.520          P=0.272          P=0.492                          |
|POLY 3             |        P=0.361          P=0.514          P=0.511          P=0.255          P=0.500                          |
|POLY 1.5           |        P=0.362          P=0.508          P=0.505          P=0.246          P=0.498                          |
|POLY 6             |        P=0.359          P=0.522          P=0.519          P=0.269          P=0.502                          |
|LOGISTIC REGRESSION|        P=0.369          P=0.509          P=0.498          P=0.235          P=0.499                          |
|COCH-ARM / FISHERS |        P=0.374          P=0.500          P=0.500          P=0.247          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        9/50 (18%)       4/50 (8%)        1/50 (2%)        3/48 (6%)                        |
|POLY-3 ADJUSTED (b)|        4.6%             19.2%            8.9%             2.1%             6.4%                             |
|TERMINAL (d)       |        1/23 (4%)        8/40 (20%)       4/35 (11%)       1/37 (3%)        3/40 (8%)                        |
|FIRST INCIDENCE    |        718              592              730 (T)          730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.096N         P=0.136          P=0.538          P=0.343N         P=0.623N                         |
|POLY 3             |        P=0.158N         P=0.035 *        P=0.357          P=0.469N         P=0.539                          |
|POLY 1.5           |        P=0.181N         P=0.030 *        P=0.343          P=0.484N         P=0.512                          |
|POLY 6             |        P=0.127N         P=0.046 *        P=0.384          P=0.446N         P=0.581                          |
|LOGISTIC REGRESSION|        P=0.133N         P=0.044 *        P=0.498          P=0.382N         P=0.665N                         |
|COCH-ARM / FISHERS |        P=0.216N         P=0.026 *        P=0.339          P=0.500N         P=0.480                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        4/50 (8%)        5/50 (10%)       5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        2.4%             4.6%             9.3%             11.1%            12.0%                            |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        681              676              704              628              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.059          P=0.549          P=0.227          P=0.164          P=0.122                          |
|POLY 3             |        P=0.062          P=0.525          P=0.192          P=0.123          P=0.105                          |
|POLY 1.5           |        P=0.061          P=0.514          P=0.185          P=0.112          P=0.101                          |
|POLY 6             |        P=0.066          P=0.540          P=0.203          P=0.142          P=0.112                          |
|LOGISTIC REGRESSION|        P=0.063          P=0.509          P=0.206          P=0.097          P=0.103                          |
|COCH-ARM / FISHERS |        P=0.064          P=0.500          P=0.181          P=0.102          P=0.102                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             0.0%             0.0%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        ---              710              ---              ---              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.394          P=0.538          (e)              (e)              P=0.500                          |
|POLY 3             |        P=0.407          P=0.514          (e)              (e)              P=0.500                          |
|POLY 1.5           |        P=0.404          P=0.508          (e)              (e)              P=0.498                          |
|POLY 6             |        P=0.410          P=0.523          (e)              (e)              P=0.502                          |
|LOGISTIC REGRESSION|        P=0.394          P=0.524          (e)              (e)              P=0.500                          |
|COCH-ARM / FISHERS |        P=0.404          P=0.500          (e)              (e)              P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.3%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.255N         P=0.367          (e)              (e)              (e)                              |
|POLY 3             |        P=0.285N         P=0.255          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.295N         P=0.246          (e)              (e)              (e)                              |
|POLY 6             |        P=0.268N         P=0.271          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.367          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.310N         P=0.247          (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/50 (12%)       0/50 (0%)        1/50 (2%)        1/50 (2%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        14.4%            0.0%             2.3%             2.3%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        620              ---              699              729 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.021N*        P=0.014N*        P=0.050N         P=0.042N*        P=0.021N*                        |
|POLY 3             |        P=0.020N*        P=0.013N*        P=0.051N         P=0.048N*        P=0.016N*                        |
|POLY 1.5           |        P=0.019N*        P=0.014N*        P=0.054N         P=0.052N         P=0.016N*                        |
|POLY 6             |        P=0.021N*        P=0.011N*        P=0.047N*        P=0.043N*        P=0.016N*                        |
|LOGISTIC REGRESSION|        P=0.020N*        P=0.017N*        P=0.056N         P=0.053N         P=0.018N*                        |
|COCH-ARM / FISHERS |        P=0.020N*        P=0.013N*        P=0.056N         P=0.056N         P=0.013N*                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/48 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.6%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        605              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.534N         P=0.232N         P=0.234N         P=0.223N         P=0.412N                         |
|POLY 3             |        P=0.600N         P=0.224N         P=0.231N         P=0.221N         P=0.476N                         |
|POLY 1.5           |        P=0.593N         P=0.230N         P=0.236N         P=0.229N         P=0.493N                         |
|POLY 6             |        P=0.613N         P=0.212N         P=0.221N         P=0.210N         P=0.447N                         |
|LOGISTIC REGRESSION|        P=0.637N         P=0.276N         P=0.203N         P=0.374N         P=0.717N                         |
|COCH-ARM / FISHERS |        P=0.587N         P=0.247N         P=0.247N         P=0.247N         P=0.515N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             0.0%             0.0%             0.0%             5.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        674              ---              ---              ---              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.365          P=0.214N         P=0.210N         P=0.193N         P=0.671N                         |
|POLY 3             |        P=0.348          P=0.224N         P=0.229N         P=0.223N         P=0.688                          |
|POLY 1.5           |        P=0.352          P=0.229N         P=0.233N         P=0.230N         P=0.683                          |
|POLY 6             |        P=0.344          P=0.217N         P=0.223N         P=0.214N         P=0.694                          |
|LOGISTIC REGRESSION|        P=0.357          P=0.240N         P=0.237N         P=0.239N         P=0.687                          |
|COCH-ARM / FISHERS |        P=0.360          P=0.247N         P=0.247N         P=0.247N         P=0.684                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/49 (0%)        0/49 (0%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              635              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.653          (e)              (e)              P=0.518          (e)                              |
|POLY 3             |        P=0.672          (e)              (e)              P=0.519          (e)                              |
|POLY 1.5           |        P=0.657          (e)              (e)              P=0.510          (e)                              |
|POLY 6             |        P=0.695          (e)              (e)              P=0.534          (e)                              |
|LOGISTIC REGRESSION|        P=0.621          (e)              (e)              P=0.385          (e)                              |
|COCH-ARM / FISHERS |        P=0.640          (e)              (e)              P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             2.3%             2.3%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        1/22 (5%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.200N         P=0.753N         P=0.763          P=0.467N         P=0.500N                         |
|POLY 3             |        P=0.206N         P=0.745N         P=0.750N         P=0.486N         P=0.500N                         |
|POLY 1.5           |        P=0.208N         P=0.752N         P=0.756N         P=0.493N         P=0.502N                         |
|POLY 6             |        P=0.202N         P=0.736N         P=0.743N         P=0.475N         P=0.498N                         |
|LOGISTIC REGRESSION|        P=0.200N         P=0.753N         P=0.763          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.207N         P=0.753N         P=0.753N         P=0.500N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        2/49 (4%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.2%             4.5%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        2/35 (6%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              513              730 (T)          730 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.272N         P=0.244          P=0.335          P=0.595          (e)                              |
|POLY 3             |        P=0.285N         P=0.260          P=0.242          P=0.518          (e)                              |
|POLY 1.5           |        P=0.304N         P=0.249          P=0.235          P=0.509          (e)                              |
|POLY 6             |        P=0.257N         P=0.279          P=0.255          P=0.531          (e)                              |
|LOGISTIC REGRESSION|        P=0.366N         P=0.214          P=0.335          P=0.595          (e)                              |
|COCH-ARM / FISHERS |        P=0.325N         P=0.247          P=0.242          P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       7/50 (14%)       7/50 (14%)       5/50 (10%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        12.0%            16.0%            16.3%            11.4%            7.4%                             |
|TERMINAL (d)       |        2/22 (9%)        6/23 (26%)       4/22 (18%)       5/26 (19%)       3/22 (14%)                       |
|FIRST INCIDENCE    |        620              724              705              729 (T)          729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.152N         P=0.427          P=0.420          P=0.529N         P=0.348N                         |
|POLY 3             |        P=0.172N         P=0.412          P=0.399          P=0.600N         P=0.369N                         |
|POLY 1.5           |        P=0.171N         P=0.399          P=0.388          P=0.615N         P=0.368N                         |
|POLY 6             |        P=0.175N         P=0.427          P=0.413          P=0.580N         P=0.372N                         |
|LOGISTIC REGRESSION|        P=0.162N         P=0.456          P=0.426          P=0.573N         P=0.355N                         |
|COCH-ARM / FISHERS |        P=0.159N         P=0.380          P=0.380          P=0.630N         P=0.357N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/50 (12%)       11/50 (22%)      2/49 (4%)        8/50 (16%)       0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        13.9%            23.4%            4.5%             17.0%            0.0%                             |
|TERMINAL (d)       |        5/23 (22%)       10/40 (25%)      1/35 (3%)        6/37 (16%)       0/40 (0%)                        |
|FIRST INCIDENCE    |        676              592              571              723              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.002N**       P=0.518          P=0.055N         P=0.478N         P=0.002N**                       |
|POLY 3             |        P=0.004N**       P=0.186          P=0.122N         P=0.454          P=0.010N*                        |
|POLY 1.5           |        P=0.006N**       P=0.164          P=0.134N         P=0.422          P=0.013N*                        |
|POLY 6             |        P=0.003N**       P=0.230          P=0.104N         P=0.506          P=0.008N**                       |
|LOGISTIC REGRESSION|        P=0.005N**       P=0.247          P=0.132N         P=0.601N         P=0.005N**                       |
|COCH-ARM / FISHERS |        P=0.010N*        P=0.143          P=0.141N         P=0.387          P=0.013N*                        |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             4.9%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.021 *        (e)              (e)              (e)              P=0.251                          |
|POLY 3             |        P=0.021 *        (e)              (e)              (e)              P=0.237                          |
|POLY 1.5           |        P=0.021 *        (e)              (e)              (e)              P=0.235                          |
|POLY 6             |        P=0.021 *        (e)              (e)              (e)              P=0.240                          |
|LOGISTIC REGRESSION|        P=0.020 *        (e)              (e)              (e)              P=0.240                          |
|COCH-ARM / FISHERS |        P=0.023 *        (e)              (e)              (e)              P=0.247                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/50 (2%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             2.3%             2.3%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        708              718              719              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.107N         P=0.456N         P=0.469N         P=0.199N         P=0.249N                         |
|POLY 3             |        P=0.107N         P=0.476N         P=0.484N         P=0.222N         P=0.238N                         |
|POLY 1.5           |        P=0.108N         P=0.486N         P=0.492N         P=0.229N         P=0.240N                         |
|POLY 6             |        P=0.107N         P=0.462N         P=0.472N         P=0.211N         P=0.235N                         |
|LOGISTIC REGRESSION|        P=0.103N         P=0.450N         P=0.458N         P=0.198N         P=0.234N                         |
|COCH-ARM / FISHERS |        P=0.106N         P=0.500N         P=0.500N         P=0.247N         P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Accumulation, Hyaline Droplet                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        14/50 (28%)      10/50 (20%)      16/50 (32%)      16/50 (32%)                      |
|POLY-3 ADJUSTED (b)|        7.4%             30.3%            22.3%            34.5%            37.2%                            |
|TERMINAL (d)       |        2/22 (9%)        6/23 (26%)       5/22 (23%)       8/26 (31%)       11/22 (50%)                      |
|FIRST INCIDENCE    |        724              481              312              249              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009 **       P=0.010 *        P=0.045 *        P=0.005 **       P<0.001 **                       |
|POLY 3             |        P=0.006 **       P=0.006 **       P=0.050          P=0.002 **       P<0.001 **                       |
|POLY 1.5           |        P=0.006 **       P=0.004 **       P=0.043 *        P<0.001 **       P<0.001 **                       |
|POLY 6             |        P=0.006 **       P=0.010 *        P=0.061          P=0.003 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.009 **       P=0.004 **       P=0.034 *        P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P=0.007 **       P=0.003 **       P=0.036 *        P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Accumulation, Hyaline Droplet                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        33/50 (66%)      48/50 (96%)      45/50 (90%)      44/50 (88%)      44/49 (90%)                      |
|POLY-3 ADJUSTED (b)|        71.4%            97.1%            91.7%            90.8%            91.2%                            |
|TERMINAL (d)       |        21/23 (91%)      40/40 (100%)     33/35 (94%)      37/37 (100%)     37/40 (93%)                      |
|FIRST INCIDENCE    |        550              513              85               550              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.053N         P=0.333N         P=0.509N         P=0.210N         P=0.083N                         |
|POLY 3             |        P=0.073          P<0.001 **       P=0.005 **       P=0.008 **       P=0.008 **                       |
|POLY 1.5           |        P=0.050          P<0.001 **       P=0.004 **       P=0.007 **       P=0.005 **                       |
|POLY 6             |        P=0.153          P<0.001 **       P=0.012 *        P=0.009 **       P=0.022 *                        |
|LOGISTIC REGRESSION|        P=0.089          P<0.001 **       P=0.004 **       P=0.056          P=0.028 *                        |
|COCH-ARM / FISHERS |        P=0.043 *        P<0.001 **       P=0.004 **       P=0.008 **       P=0.004 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        9/50 (18%)       7/50 (14%)       13/50 (26%)                      |
|POLY-3 ADJUSTED (b)|        7.3%             9.1%             20.7%            15.9%            30.7%                            |
|TERMINAL (d)       |        2/22 (9%)        1/23 (4%)        4/22 (18%)       4/26 (15%)       4/22 (18%)                       |
|FIRST INCIDENCE    |        565              676              596              681              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.003 **       P=0.551          P=0.083          P=0.243          P=0.013 *                        |
|POLY 3             |        P=0.002 **       P=0.535          P=0.070          P=0.183          P=0.005 **                       |
|POLY 1.5           |        P=0.002 **       P=0.519          P=0.065          P=0.170          P=0.005 **                       |
|POLY 6             |        P=0.002 **       P=0.556          P=0.080          P=0.204          P=0.007 **                       |
|LOGISTIC REGRESSION|        P=0.002 **       P=0.529          P=0.070          P=0.202          P=0.007 **                       |
|COCH-ARM / FISHERS |        P=0.002 **       P=0.500          P=0.061          P=0.159          P=0.006 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             4.6%             0.0%             4.8%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        555              ---              643              ---              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.482          P=0.225N         P=0.660N         P=0.225N         P=0.686                          |
|POLY 3             |        P=0.487          P=0.226N         P=0.682N         P=0.226N         P=0.694N                         |
|POLY 1.5           |        P=0.490          P=0.231N         P=0.688N         P=0.232N         P=0.694                          |
|POLY 6             |        P=0.484          P=0.221N         P=0.672N         P=0.218N         P=0.694N                         |
|LOGISTIC REGRESSION|        P=0.525N         P=0.304N         P=0.695          P=0.215N         P=0.521N                         |
|COCH-ARM / FISHERS |        P=0.496          P=0.247N         P=0.691N         P=0.247N         P=0.691N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.4%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              718              ---              709                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.487          (e)              P=0.331          (e)              P=0.599                          |
|POLY 3             |        P=0.434          (e)              P=0.247          (e)              P=0.519                          |
|POLY 1.5           |        P=0.418          (e)              P=0.240          (e)              P=0.508                          |
|POLY 6             |        P=0.459          (e)              P=0.261          (e)              P=0.537                          |
|LOGISTIC REGRESSION|        P=0.436          (e)              P=0.287          (e)              P=0.507                          |
|COCH-ARM / FISHERS |        P=0.402          (e)              P=0.247          (e)              P=0.495                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        7/50 (14%)       5/50 (10%)       2/50 (4%)        5/50 (10%)       4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        17.0%            11.4%            4.7%             11.4%            9.6%                             |
|TERMINAL (d)       |        5/22 (23%)       4/23 (17%)       2/22 (9%)        5/26 (19%)       2/22 (9%)                        |
|FIRST INCIDENCE    |        645              676              729 (T)          729 (T)          61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.298N         P=0.332N         P=0.073N         P=0.263N         P=0.255N                         |
|POLY 3             |        P=0.320N         P=0.334N         P=0.069N         P=0.336N         P=0.250N                         |
|POLY 1.5           |        P=0.318N         P=0.354N         P=0.074N         P=0.358N         P=0.256N                         |
|POLY 6             |        P=0.323N         P=0.310N         P=0.062N         P=0.307N         P=0.243N                         |
|LOGISTIC REGRESSION|        P=0.323N         P=0.287N         P=0.056N         P=0.259N         P=0.247N                         |
|COCH-ARM / FISHERS |        P=0.314N         P=0.380N         P=0.080N         P=0.380N         P=0.262N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        6.9%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/23 (4%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        635              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.057N         P=0.069N         P=0.080N         P=0.072N         P=0.063N                         |
|POLY 3             |        P=0.078N         P=0.107N         P=0.112N         P=0.105N         P=0.104N                         |
|POLY 1.5           |        P=0.074N         P=0.113N         P=0.117N         P=0.111N         P=0.113N                         |
|POLY 6             |        P=0.086N         P=0.097N         P=0.103N         P=0.095N         P=0.092N                         |
|LOGISTIC REGRESSION|        P=0.075N         P=0.124N         P=0.120N         P=0.126N         P=0.135N                         |
|COCH-ARM / FISHERS |        P=0.074N         P=0.121N         P=0.121N         P=0.121N         P=0.125N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization Diffuse                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        9/50 (18%)       8/50 (16%)       6/50 (12%)                       |
|POLY-3 ADJUSTED (b)|        4.8%             4.6%             20.2%            17.6%            14.0%                            |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        555              676              561              620              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.105          P=0.646N         P=0.050          P=0.101          P=0.156                          |
|POLY 3             |        P=0.105          P=0.673N         P=0.032 *        P=0.061          P=0.142                          |
|POLY 1.5           |        P=0.103          P=0.682N         P=0.029 *        P=0.053          P=0.137                          |
|POLY 6             |        P=0.112          P=0.661N         P=0.040 *        P=0.076          P=0.150                          |
|LOGISTIC REGRESSION|        P=0.145          P=0.657          P=0.025 *        P=0.041 *        P=0.183                          |
|COCH-ARM / FISHERS |        P=0.105          P=0.691N         P=0.026 *        P=0.046 *        P=0.134                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization Diffuse                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        50/50 (100%)     50/50 (100%)     50/50 (100%)     50/50 (100%)     50/50 (100%)                     |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           100.0%           100.0%           100.0%                           |
|TERMINAL (d)       |        22/22 (100%)     23/23 (100%)     22/22 (100%)     26/26 (100%)     22/22 (100%)                     |
|FIRST INCIDENCE    |        485              477              312              249              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        39/50 (78%)      49/50 (98%)      47/50 (94%)      49/50 (98%)      49/49 (100%)                     |
|POLY-3 ADJUSTED (b)|        81.7%            98.6%            96.6%            98.0%            100.0%                           |
|TERMINAL (d)       |        22/23 (96%)      40/40 (100%)     34/35 (97%)      36/37 (97%)      40/40 (100%)                     |
|FIRST INCIDENCE    |        550              513              506              550              486                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.097N         P=0.064N         P=0.196N         P=0.154N         P=0.031N*                        |
|POLY 3             |        P<0.001 **       P=0.002 **       P=0.012 *        P=0.004 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.002 **       P=0.010 *        P=0.003 **       P<0.001 **                       |
|POLY 6             |        P=0.003 **       P=0.003 **       P=0.020 *        P=0.010 *        P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.005 **       P=0.015 *        P=0.006 **       P=0.002 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.002 **       P=0.020 *        P=0.002 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/50 (50%)      31/50 (62%)      36/50 (72%)      38/50 (76%)      33/50 (66%)                      |
|POLY-3 ADJUSTED (b)|        56.1%            66.6%            77.8%            81.8%            74.5%                            |
|TERMINAL (d)       |        14/22 (64%)      15/23 (65%)      19/22 (86%)      24/26 (92%)      19/22 (86%)                      |
|FIRST INCIDENCE    |        499              597              561              537              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.131          P=0.342          P=0.079          P=0.122          P=0.123                          |
|POLY 3             |        P=0.036 *        P=0.199          P=0.017 *        P=0.004 **       P=0.043 *                        |
|POLY 1.5           |        P=0.046 *        P=0.176          P=0.016 *        P=0.004 **       P=0.049 *                        |
|POLY 6             |        P=0.026 *        P=0.246          P=0.023 *        P=0.005 **       P=0.038 *                        |
|LOGISTIC REGRESSION|        P=0.054          P=0.230          P=0.028 *        P=0.014 *        P=0.065                          |
|COCH-ARM / FISHERS |        P=0.091          P=0.157          P=0.020 *        P=0.006 **       P=0.078                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        27/50 (54%)      50/50 (100%)     48/50 (96%)      50/50 (100%)     47/49 (96%)                      |
|POLY-3 ADJUSTED (b)|        57.6%            100.0%           99.0%            100.0%           95.9%                            |
|TERMINAL (d)       |        12/23 (52%)      40/40 (100%)     35/35 (100%)     37/37 (100%)     38/40 (95%)                      |
|FIRST INCIDENCE    |        571              513              506              550              486                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.464N         P=0.150          P=0.088          P=0.105          P=0.372                          |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Medulla                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        30/50 (60%)      42/50 (84%)      46/50 (92%)      47/50 (94%)      49/50 (98%)                      |
|POLY-3 ADJUSTED (b)|        65.4%            87.7%            94.9%            94.5%            100.0%                           |
|TERMINAL (d)       |        12/22 (55%)      21/23 (91%)      22/22 (100%)     24/26 (92%)      22/22 (100%)                     |
|FIRST INCIDENCE    |        537              597              312              249              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.010 *        P=0.137          P=0.034 *        P=0.088          P=0.008 **                       |
|POLY 3             |        P<0.001 **       P=0.006 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.005 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P=0.008 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.014 *        P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.007 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Medulla                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        17/50 (34%)      25/50 (50%)      27/50 (54%)      28/50 (56%)      20/49 (41%)                      |
|POLY-3 ADJUSTED (b)|        36.8%            51.4%            56.5%            58.6%            42.3%                            |
|TERMINAL (d)       |        4/23 (17%)       20/40 (50%)      17/35 (49%)      23/37 (62%)      18/40 (45%)                      |
|FIRST INCIDENCE    |        550              513              506              638              712                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.124N         P=0.562          P=0.317          P=0.382          P=0.213N                         |
|POLY 3             |        P=0.523N         P=0.108          P=0.040 *        P=0.025 *        P=0.371                          |
|POLY 1.5           |        P=0.522          P=0.093          P=0.033 *        P=0.022 *        P=0.341                          |
|POLY 6             |        P=0.469N         P=0.136          P=0.055          P=0.029 *        P=0.426                          |
|LOGISTIC REGRESSION|        P=0.523          P=0.048 *        P=0.035 *        P=0.029 *        P=0.319                          |
|COCH-ARM / FISHERS |        P=0.488          P=0.078          P=0.035 *        P=0.022 *        P=0.311                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        7/50 (14%)       3/50 (6%)        9/50 (18%)       9/50 (18%)                       |
|POLY-3 ADJUSTED (b)|        7.3%             15.8%            7.0%             20.4%            21.8%                            |
|TERMINAL (d)       |        2/22 (9%)        3/23 (13%)       1/22 (5%)        7/26 (27%)       6/22 (27%)                       |
|FIRST INCIDENCE    |        690              669              719              620              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.039 *        P=0.209          P=0.627N         P=0.112          P=0.069                          |
|POLY 3             |        P=0.035 *        P=0.189          P=0.642N         P=0.077          P=0.058                          |
|POLY 1.5           |        P=0.035 *        P=0.175          P=0.652N         P=0.068          P=0.057                          |
|POLY 6             |        P=0.035 *        P=0.210          P=0.627N         P=0.091          P=0.061                          |
|LOGISTIC REGRESSION|        P=0.030 *        P=0.209          P=0.607N         P=0.100          P=0.061                          |
|COCH-ARM / FISHERS |        P=0.040 *        P=0.159          P=0.661N         P=0.061          P=0.061                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        12/50 (24%)      13/50 (26%)      15/50 (30%)      11/49 (22%)                      |
|POLY-3 ADJUSTED (b)|        0.0%             25.6%            28.8%            31.7%            23.2%                            |
|TERMINAL (d)       |        0/23 (0%)        11/40 (28%)      11/35 (31%)      14/37 (38%)      9/40 (23%)                       |
|FIRST INCIDENCE    |        ---              592              703              638              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.183          P=0.005 **       P=0.002 **       P<0.001 **       P=0.010 *                        |
|POLY 3             |        P=0.071          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P=0.049 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P=0.121          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.113          P<0.001 **       P<0.001 **       P<0.001 **       P=0.003 **                       |
|COCH-ARM / FISHERS |        P=0.036 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia Oncocytic                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.3%             2.4%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          667                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.160          (e)              (e)              P=0.533          P=0.517                          |
|POLY 3             |        P=0.151          (e)              (e)              P=0.514          P=0.501                          |
|POLY 1.5           |        P=0.153          (e)              (e)              P=0.507          P=0.498                          |
|POLY 6             |        P=0.149          (e)              (e)              P=0.525          P=0.504                          |
|LOGISTIC REGRESSION|        P=0.154          (e)              (e)              P=0.533          P=0.500                          |
|COCH-ARM / FISHERS |        P=0.159          (e)              (e)              P=0.500          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia Oncocytic                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.3%             0.0%             2.1%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        0/35 (0%)        1/37 (3%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.590          P=0.367          (e)              P=0.595          P=0.610                          |
|POLY 3             |        P=0.544          P=0.255          (e)              P=0.518          P=0.519                          |
|POLY 1.5           |        P=0.524          P=0.246          (e)              P=0.509          P=0.508                          |
|POLY 6             |        P=0.576          P=0.271          (e)              P=0.531          P=0.537                          |
|LOGISTIC REGRESSION|        (e)              P=0.367          (e)              P=0.595          P=0.610                          |
|COCH-ARM / FISHERS |        P=0.500          P=0.247          (e)              P=0.500          P=0.495                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Transitional Epithelium                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        28/50 (56%)      45/50 (90%)      44/50 (88%)      48/50 (96%)      48/50 (96%)                      |
|POLY-3 ADJUSTED (b)|        64.5%            93.1%            93.5%            97.9%            99.5%                            |
|TERMINAL (d)       |        16/22 (73%)      22/23 (96%)      22/22 (100%)     25/26 (96%)      22/22 (100%)                     |
|FIRST INCIDENCE    |        593              481              561              537              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009 **       P=0.024 *        P=0.018 *        P=0.026 *        P=0.002 **                       |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Transitional Epithelium                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        5/50 (10%)       12/50 (24%)      3/50 (6%)        10/49 (20%)                      |
|POLY-3 ADJUSTED (b)|        0.0%             10.8%            26.3%            6.4%             21.2%                            |
|TERMINAL (d)       |        0/23 (0%)        5/40 (13%)       9/35 (26%)       3/37 (8%)        10/40 (25%)                      |
|FIRST INCIDENCE    |        ---              730 (T)          571              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.076          P=0.102          P=0.003 **       P=0.216          P=0.013 *                        |
|POLY 3             |        P=0.027 *        P=0.037 *        P<0.001 **       P=0.135          P<0.001 **                       |
|POLY 1.5           |        P=0.021 *        P=0.034 *        P<0.001 **       P=0.128          P<0.001 **                       |
|POLY 6             |        P=0.041 *        P=0.044 *        P<0.001 **       P=0.149          P=0.002 **                       |
|LOGISTIC REGRESSION|        P=0.048 *        P=0.102          P<0.001 **       P=0.216          P=0.013 *                        |
|COCH-ARM / FISHERS |        P=0.018 *        P=0.028 *        P<0.001 **       P=0.121          P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/50 (12%)       21/50 (42%)      13/50 (26%)      9/50 (18%)       9/50 (18%)                       |
|POLY-3 ADJUSTED (b)|        14.7%            46.7%            29.9%            20.5%            21.0%                            |
|TERMINAL (d)       |        5/22 (23%)       12/23 (52%)      8/22 (36%)       7/26 (27%)       2/22 (9%)                        |
|FIRST INCIDENCE    |        724              663              643              681              466                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.191N         P=0.002 **       P=0.076          P=0.419          P=0.309                          |
|POLY 3             |        P=0.138N         P<0.001 **       P=0.076          P=0.342          P=0.320                          |
|POLY 1.5           |        P=0.163N         P<0.001 **       P=0.068          P=0.314          P=0.298                          |
|POLY 6             |        P=0.106N         P<0.001 **       P=0.093          P=0.385          P=0.357                          |
|LOGISTIC REGRESSION|        P=0.197N         P=0.002 **       P=0.096          P=0.445          P=0.282                          |
|COCH-ARM / FISHERS |        P=0.185N         P<0.001 **       P=0.062          P=0.288          P=0.288                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        15/50 (30%)      18/50 (36%)      15/50 (30%)      21/49 (43%)                      |
|POLY-3 ADJUSTED (b)|        6.9%             32.3%            39.1%            31.7%            44.2%                            |
|TERMINAL (d)       |        2/23 (9%)        15/40 (38%)      14/35 (40%)      11/37 (30%)      18/40 (45%)                      |
|FIRST INCIDENCE    |        681              730 (T)          571              689              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.026 *        P=0.039 *        P=0.005 **       P=0.033 *        P=0.004 **                       |
|POLY 3             |        P=0.002 **       P=0.002 **       P<0.001 **       P=0.003 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.002 **       P<0.001 **       P=0.002 **       P<0.001 **                       |
|POLY 6             |        P=0.005 **       P=0.003 **       P<0.001 **       P=0.004 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.007 **       P=0.014 *        P<0.001 **       P=0.009 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.002 **       P<0.001 **       P=0.002 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/50 (50%)      35/50 (70%)      35/50 (70%)      32/50 (64%)      23/50 (46%)                      |
|POLY-3 ADJUSTED (b)|        58.5%            76.0%            77.0%            70.4%            53.9%                            |
|TERMINAL (d)       |        18/22 (82%)      21/23 (91%)      20/22 (91%)      21/26 (81%)      13/22 (59%)                      |
|FIRST INCIDENCE    |        540              641              561              628              593                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.100N         P=0.098          P=0.067          P=0.411          P=0.395N                         |
|POLY 3             |        P=0.073N         P=0.048 *        P=0.037 *        P=0.157          P=0.410N                         |
|POLY 1.5           |        P=0.086N         P=0.038 *        P=0.031 *        P=0.127          P=0.436N                         |
|POLY 6             |        P=0.054N         P=0.074          P=0.055          P=0.218          P=0.359N                         |
|LOGISTIC REGRESSION|        P=0.076N         P=0.108          P=0.063          P=0.309          P=0.379N                         |
|COCH-ARM / FISHERS |        P=0.081N         P=0.033 *        P=0.033 *        P=0.113          P=0.421N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        37/50 (74%)      50/50 (100%)     34/50 (68%)      33/50 (66%)      15/49 (31%)                      |
|POLY-3 ADJUSTED (b)|        79.4%            100.0%           71.9%            68.7%            31.6%                            |
|TERMINAL (d)       |        23/23 (100%)     40/40 (100%)     27/35 (77%)      27/37 (73%)      13/40 (33%)                      |
|FIRST INCIDENCE    |        550              513              506              611              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.155N         P=0.004N**       P<0.001N**       P<0.001N**                       |
|POLY 3             |        P<0.001N**       P<0.001 **       P=0.260N         P=0.157N         P<0.001N**                       |
|POLY 1.5           |        P<0.001N**       P<0.001 **       P=0.317N         P=0.202N         P<0.001N**                       |
|POLY 6             |        P<0.001N**       P<0.001 **       P=0.172N         P=0.095N         P<0.001N**                       |
|LOGISTIC REGRESSION|        P<0.001N**       P<0.001 **       P=0.267N         P=0.064N         P<0.001N**                       |
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001 **       P=0.330N         P=0.257N         P<0.001N**                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 48
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/50 (18%)       5/50 (10%)       6/50 (12%)       8/50 (16%)       5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        22.1%            11.5%            14.1%            18.3%            12.3%                            |
|TERMINAL (d)       |        9/22 (41%)       5/23 (22%)       6/22 (27%)       8/26 (31%)       4/22 (18%)                       |
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          729 (T)          677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.263N         P=0.146N         P=0.265N         P=0.336N         P=0.172N                         |
|POLY 3             |        P=0.319N         P=0.151N         P=0.250N         P=0.434N         P=0.185N                         |
|POLY 1.5           |        P=0.317N         P=0.170N         P=0.269N         P=0.467N         P=0.195N                         |
|POLY 6             |        P=0.320N         P=0.129N         P=0.222N         P=0.386N         P=0.171N                         |
|LOGISTIC REGRESSION|        P=0.321N         P=0.146N         P=0.265N         P=0.336N         P=0.183N                         |
|COCH-ARM / FISHERS |        P=0.297N         P=0.194N         P=0.288N         P=0.500N         P=0.194N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        2/50 (4%)        6/50 (12%)       3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             6.5%             4.4%             12.8%            6.4%                             |
|TERMINAL (d)       |        1/23 (4%)        3/40 (8%)        2/35 (6%)        6/37 (16%)       3/40 (8%)                        |
|FIRST INCIDENCE    |        730 (T)          730 (T)          730 (T)          730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.375          P=0.517          P=0.645          P=0.166          P=0.517                          |
|POLY 3             |        P=0.275          P=0.333          P=0.516          P=0.071          P=0.340                          |
|POLY 1.5           |        P=0.248          P=0.320          P=0.505          P=0.064          P=0.320                          |
|POLY 6             |        P=0.321          P=0.359          P=0.536          P=0.085          P=0.375                          |
|LOGISTIC REGRESSION|        P=0.375          P=0.517          P=0.645          P=0.166          P=0.517                          |
|COCH-ARM / FISHERS |        P=0.218          P=0.309          P=0.500          P=0.056          P=0.301                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 49
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/50 (18%)       31/50 (62%)      36/50 (72%)      28/50 (56%)      29/50 (58%)                      |
|POLY-3 ADJUSTED (b)|        21.8%            66.8%            77.1%            59.0%            65.4%                            |
|TERMINAL (d)       |        5/22 (23%)       15/23 (65%)      16/22 (73%)      12/26 (46%)      11/22 (50%)                      |
|FIRST INCIDENCE    |        677              597              561              537              607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.044 *        P<0.001 **       P<0.001 **       P=0.004 **       P<0.001 **                       |
|POLY 3             |        P=0.018 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P=0.011 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P=0.040 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.010 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P=0.018 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        5/50 (10%)       10/50 (20%)      10/50 (20%)      6/49 (12%)                       |
|POLY-3 ADJUSTED (b)|        0.0%             10.6%            22.0%            20.6%            12.7%                            |
|TERMINAL (d)       |        0/23 (0%)        3/40 (8%)        8/35 (23%)       4/37 (11%)       5/40 (13%)                       |
|FIRST INCIDENCE    |        ---              647              625              550              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.253          P=0.082          P=0.007 **       P=0.008 **       P=0.067                          |
|POLY 3             |        P=0.152          P=0.039 *        P<0.001 **       P=0.002 **       P=0.021 *                        |
|POLY 1.5           |        P=0.122          P=0.035 *        P<0.001 **       P<0.001 **       P=0.018 *                        |
|POLY 6             |        P=0.210          P=0.047 *        P=0.002 **       P=0.003 **       P=0.029 *                        |
|LOGISTIC REGRESSION|        P=0.094          P=0.033 *        P=0.002 **       P<0.001 **       P=0.034 *                        |
|COCH-ARM / FISHERS |        P=0.097          P=0.028 *        P<0.001 **       P<0.001 **       P=0.012 *                        |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 50
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/50 (18%)       22/50 (44%)      30/50 (60%)      29/50 (58%)      20/50 (40%)                      |
|POLY-3 ADJUSTED (b)|        21.9%            49.8%            66.7%            63.9%            47.7%                            |
|TERMINAL (d)       |        7/22 (32%)       18/23 (78%)      18/22 (82%)      22/26 (85%)      16/22 (73%)                      |
|FIRST INCIDENCE    |        677              663              603              605              466                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.097          P=0.004 **       P<0.001 **       P<0.001 **       P=0.009 **                       |
|POLY 3             |        P=0.082          P=0.005 **       P<0.001 **       P<0.001 **       P=0.009 **                       |
|POLY 1.5           |        P=0.081          P=0.004 **       P<0.001 **       P<0.001 **       P=0.010 *                        |
|POLY 6             |        P=0.081          P=0.005 **       P<0.001 **       P<0.001 **       P=0.009 **                       |
|LOGISTIC REGRESSION|        P=0.070          P=0.009 **       P<0.001 **       P<0.001 **       P=0.011 *                        |
|COCH-ARM / FISHERS |        P=0.113          P=0.004 **       P<0.001 **       P<0.001 **       P=0.013 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/50 (16%)       32/50 (64%)      34/50 (68%)      39/50 (78%)      34/49 (69%)                      |
|POLY-3 ADJUSTED (b)|        18.5%            68.1%            72.6%            81.2%            71.8%                            |
|TERMINAL (d)       |        7/23 (30%)       29/40 (73%)      27/35 (77%)      32/37 (87%)      32/40 (80%)                      |
|FIRST INCIDENCE    |        645              647              506              550              712                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.023 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 51
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        3/50 (6%)        3/50 (6%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             2.3%             7.0%             6.8%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        648              645              705              593              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.252N         P=0.447N         P=0.548          P=0.581          P=0.238N                         |
|POLY 3             |        P=0.259N         P=0.478N         P=0.517          P=0.533          P=0.240N                         |
|POLY 1.5           |        P=0.255N         P=0.488N         P=0.508          P=0.517          P=0.241N                         |
|POLY 6             |        P=0.265N         P=0.467N         P=0.529          P=0.555          P=0.240N                         |
|LOGISTIC REGRESSION|        P=0.236N         P=0.552N         P=0.510          P=0.483          P=0.229N                         |
|COCH-ARM / FISHERS |        P=0.239N         P=0.500N         P=0.500          P=0.500          P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        6.9%             2.1%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/23 (4%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        645              679              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.039N*        P=0.207N         P=0.085N         P=0.077N         P=0.065N                         |
|POLY 3             |        P=0.054N         P=0.280N         P=0.112N         P=0.105N         P=0.104N                         |
|POLY 1.5           |        P=0.052N         P=0.292N         P=0.117N         P=0.111N         P=0.113N                         |
|POLY 6             |        P=0.056N         P=0.259N         P=0.104N         P=0.096N         P=0.092N                         |
|LOGISTIC REGRESSION|        P=0.056N         P=0.326N         P=0.120N         P=0.129N         P=0.137N                         |
|COCH-ARM / FISHERS |        P=0.053N         P=0.309N         P=0.121N         P=0.121N         P=0.125N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 52
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       9/50 (18%)       2/50 (4%)        5/50 (10%)       4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        12.1%            19.8%            4.7%             11.2%            9.6%                             |
|TERMINAL (d)       |        3/22 (14%)       3/23 (13%)       1/22 (5%)        2/26 (8%)        2/22 (9%)                        |
|FIRST INCIDENCE    |        540              481              638              583              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.275N         P=0.253          P=0.205N         P=0.529N         P=0.495N                         |
|POLY 3             |        P=0.264N         P=0.244          P=0.200N         P=0.583N         P=0.495N                         |
|POLY 1.5           |        P=0.270N         P=0.222          P=0.209N         P=0.607N         P=0.502N                         |
|POLY 6             |        P=0.259N         P=0.277          P=0.188N         P=0.548N         P=0.486N                         |
|LOGISTIC REGRESSION|        P=0.244N         P=0.168          P=0.214N         P=0.624          P=0.488N                         |
|COCH-ARM / FISHERS |        P=0.268N         P=0.194          P=0.218N         P=0.630N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       10/50 (20%)      7/50 (14%)       6/50 (12%)       5/49 (10%)                       |
|POLY-3 ADJUSTED (b)|        11.4%            21.5%            15.4%            12.6%            10.6%                            |
|TERMINAL (d)       |        3/23 (13%)       9/40 (23%)       6/35 (17%)       3/37 (8%)        4/40 (10%)                       |
|FIRST INCIDENCE    |        550              718              571              638              722                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.122N         P=0.441          P=0.602          P=0.514N         P=0.339N                         |
|POLY 3             |        P=0.226N         P=0.156          P=0.404          P=0.555          P=0.583N                         |
|POLY 1.5           |        P=0.255N         P=0.143          P=0.385          P=0.529          P=0.612N                         |
|POLY 6             |        P=0.183N         P=0.183          P=0.441          P=0.598          P=0.532N                         |
|LOGISTIC REGRESSION|        P=0.245N         P=0.174          P=0.380          P=0.445          P=0.610                          |
|COCH-ARM / FISHERS |        P=0.290N         P=0.131          P=0.380          P=0.500          P=0.617                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 53
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        13/50 (26%)      30/50 (60%)      28/50 (56%)      30/50 (60%)      27/50 (54%)                      |
|POLY-3 ADJUSTED (b)|        29.3%            64.6%            61.8%            63.4%            62.6%                            |
|TERMINAL (d)       |        6/22 (27%)       19/23 (83%)      19/22 (86%)      18/26 (69%)      19/22 (86%)                      |
|FIRST INCIDENCE    |        485              481              312              537              466                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.060          P=0.004 **       P=0.005 **       P=0.011 *        P=0.005 **                       |
|POLY 3             |        P=0.019 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P=0.025 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P=0.014 *        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.039 *        P<0.001 **       P=0.002 **       P<0.001 **       P=0.003 **                       |
|COCH-ARM / FISHERS |        P=0.052          P<0.001 **       P=0.002 **       P<0.001 **       P=0.004 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/50 (50%)      46/50 (92%)      44/50 (88%)      38/50 (76%)      46/49 (94%)                      |
|POLY-3 ADJUSTED (b)|        55.0%            93.0%            91.5%            78.4%            96.6%                            |
|TERMINAL (d)       |        18/23 (78%)      38/40 (95%)      33/35 (94%)      30/37 (81%)      40/40 (100%)                     |
|FIRST INCIDENCE    |        550              513              506              550              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.507          P=0.182          P=0.096          P=0.569          P=0.285                          |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P=0.010 *        P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P=0.007 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P=0.018 *        P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.002 **       P<0.001 **       P<0.001 **       P=0.027 *        P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P=0.006 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 54
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        12/50 (24%)      15/50 (30%)      13/50 (26%)      10/50 (20%)                      |
|POLY-3 ADJUSTED (b)|        9.8%             27.5%            35.2%            29.7%            24.5%                            |
|TERMINAL (d)       |        4/22 (18%)       12/23 (52%)      14/22 (64%)      13/26 (50%)      9/22 (41%)                       |
|FIRST INCIDENCE    |        729 (T)          729 (T)          723              729 (T)          677                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.267          P=0.020 *        P=0.002 **       P=0.024 *        P=0.062                          |
|POLY 3             |        P=0.260          P=0.033 *        P=0.004 **       P=0.019 *        P=0.068                          |
|POLY 1.5           |        P=0.258          P=0.030 *        P=0.004 **       P=0.017 *        P=0.068                          |
|POLY 6             |        P=0.266          P=0.038 *        P=0.005 **       P=0.024 *        P=0.069                          |
|LOGISTIC REGRESSION|        P=0.194          P=0.020 *        (e)              P=0.024 *        P=0.058                          |
|COCH-ARM / FISHERS |        P=0.285          P=0.027 *        P=0.005 **       P=0.016 *        P=0.074                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        30/50 (60%)      20/50 (40%)      23/50 (46%)      13/49 (27%)                      |
|POLY-3 ADJUSTED (b)|        7.0%             64.1%            43.8%            48.7%            27.5%                            |
|TERMINAL (d)       |        3/23 (13%)       29/40 (73%)      17/35 (49%)      21/37 (57%)      12/40 (30%)                      |
|FIRST INCIDENCE    |        730 (T)          645              571              689              722                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.106N         P<0.001 **       P=0.002 **       P<0.001 **       P=0.086                          |
|POLY 3             |        P=0.323N         P<0.001 **       P<0.001 **       P<0.001 **       P=0.010 *                        |
|POLY 1.5           |        P=0.431N         P<0.001 **       P<0.001 **       P<0.001 **       P=0.007 **                       |
|POLY 6             |        P=0.175N         P<0.001 **       P<0.001 **       P<0.001 **       P=0.017 *                        |
|LOGISTIC REGRESSION|        P=0.159N         P<0.001 **       P<0.001 **       P<0.001 **       P=0.079                          |
|COCH-ARM / FISHERS |        P=0.519          P<0.001 **       P<0.001 **       P<0.001 **       P=0.005 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 55
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       5/50 (10%)       5/50 (10%)       7/50 (14%)       5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        11.8%            11.3%            11.4%            15.7%            11.9%                            |
|TERMINAL (d)       |        1/22 (5%)        2/23 (9%)        0/22 (0%)        2/26 (8%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        485              645              603              620              537                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.485          P=0.569N         P=0.567N         P=0.508          P=0.623                          |
|POLY 3             |        P=0.484          P=0.604N         P=0.607N         P=0.417          P=0.630                          |
|POLY 1.5           |        P=0.483          P=0.615N         P=0.619N         P=0.397          P=0.624                          |
|POLY 6             |        P=0.487          P=0.591N         P=0.586N         P=0.448          P=0.626N                         |
|LOGISTIC REGRESSION|        P=0.528          P=0.596          P=0.612          P=0.359          P=0.596N                         |
|COCH-ARM / FISHERS |        P=0.501          P=0.630N         P=0.630N         P=0.380          P=0.630N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        4/50 (8%)        5/50 (10%)       6/50 (12%)       3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        9.1%             8.5%             11.0%            12.5%            6.3%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        3/35 (9%)        3/37 (8%)        2/40 (5%)                        |
|FIRST INCIDENCE    |        645              575              570              611              712                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.292N         P=0.492N         P=0.622N         P=0.540          P=0.303N                         |
|POLY 3             |        P=0.398N         P=0.603N         P=0.523          P=0.426          P=0.459N                         |
|POLY 1.5           |        P=0.422N         P=0.622N         P=0.507          P=0.400          P=0.484N                         |
|POLY 6             |        P=0.361N         P=0.570N         P=0.553          P=0.466          P=0.419N                         |
|LOGISTIC REGRESSION|        P=0.501N         P=0.570          P=0.500          P=0.250          P=0.567N                         |
|COCH-ARM / FISHERS |        P=0.452N         P=0.643N         P=0.500          P=0.370          P=0.511N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 56
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       18/50 (36%)      23/50 (46%)      17/50 (34%)      23/50 (46%)                      |
|POLY-3 ADJUSTED (b)|        11.8%            40.2%            52.3%            38.3%            55.1%                            |
|TERMINAL (d)       |        1/22 (5%)        12/23 (52%)      16/22 (73%)      13/26 (50%)      17/22 (77%)                      |
|FIRST INCIDENCE    |        485              615              561              628              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.003 **       P=0.006 **       P<0.001 **       P=0.015 *        P<0.001 **                       |
|POLY 3             |        P<0.001 **       P=0.002 **       P<0.001 **       P=0.003 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.002 **       P<0.001 **       P=0.003 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P=0.002 **       P<0.001 **       P=0.004 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.002 **       P=0.003 **       P<0.001 **       P=0.006 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P=0.004 **       P=0.002 **       P<0.001 **       P=0.004 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       4/50 (8%)        6/50 (12%)       4/50 (8%)        4/49 (8%)                        |
|POLY-3 ADJUSTED (b)|        11.2%            8.6%             13.1%            8.4%             8.4%                             |
|TERMINAL (d)       |        0/23 (0%)        3/40 (8%)        3/35 (9%)        2/37 (5%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        550              694              570              550              709                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.269N         P=0.329N         P=0.615N         P=0.367N         P=0.296N                         |
|POLY 3             |        P=0.380N         P=0.471N         P=0.522          P=0.456N         P=0.461N                         |
|POLY 1.5           |        P=0.401N         P=0.486N         P=0.505          P=0.476N         P=0.486N                         |
|POLY 6             |        P=0.348N         P=0.444N         P=0.555          P=0.425N         P=0.419N                         |
|LOGISTIC REGRESSION|        P=0.490N         P=0.579N         P=0.517          P=0.527          P=0.629                          |
|COCH-ARM / FISHERS |        P=0.426N         P=0.500N         P=0.500          P=0.500N         P=0.513N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 57
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             0.0%             2.3%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        729 (T)          ---              705              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.317N         P=0.491N         P=0.741N         P=0.467N         P=0.500N                         |
|POLY 3             |        P=0.316N         P=0.486N         P=0.750N         P=0.486N         P=0.500N                         |
|POLY 1.5           |        P=0.315N         P=0.492N         P=0.755N         P=0.493N         P=0.502N                         |
|POLY 6             |        P=0.315N         P=0.478N         P=0.742N         P=0.475N         P=0.498N                         |
|LOGISTIC REGRESSION|        P=0.313N         (e)              P=0.738N         (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.313N         P=0.500N         P=0.753N         P=0.500N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        1/50 (2%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             0.0%             2.1%             4.2%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        1/37 (3%)        2/40 (5%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.155          P=0.610          (e)              P=0.595          P=0.367                          |
|POLY 3             |        P=0.121          P=0.515          (e)              P=0.518          P=0.259                          |
|POLY 1.5           |        P=0.114          P=0.508          (e)              P=0.509          P=0.246                          |
|POLY 6             |        P=0.134          P=0.529          (e)              P=0.531          P=0.281                          |
|LOGISTIC REGRESSION|        (e)              P=0.610          (e)              P=0.595          P=0.367                          |
|COCH-ARM / FISHERS |        P=0.105          P=0.500          (e)              P=0.500          P=0.242                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 58
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        48/50 (96%)      50/50 (100%)     47/50 (94%)      49/50 (98%)      47/50 (94%)                      |
|POLY-3 ADJUSTED (b)|        96.9%            100.0%           96.7%            98.2%            97.2%                            |
|TERMINAL (d)       |        22/22 (100%)     23/23 (100%)     22/22 (100%)     26/26 (100%)     22/22 (100%)                     |
|FIRST INCIDENCE    |        485              477              477              249              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.448N         P=0.429N         P=0.362N         P=0.203N         P=0.469N                         |
|POLY 3             |        P=0.528N         P=0.312          P=0.716N         P=0.601          P=0.717                          |
|POLY 1.5           |        P=0.487N         P=0.272          P=0.655N         P=0.552          P=0.713                          |
|POLY 6             |        P=0.608N         P=0.402          P=0.752N         P=0.683          P=0.735                          |
|LOGISTIC REGRESSION|        P=0.470N         P=0.253          P=0.507N         P=0.504          P=0.652N                         |
|COCH-ARM / FISHERS |        P=0.269N         P=0.247          P=0.500N         P=0.500          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        17/50 (34%)      22/50 (44%)      20/50 (40%)      20/50 (40%)      12/49 (24%)                      |
|POLY-3 ADJUSTED (b)|        36.9%            45.9%            43.2%            41.4%            25.4%                            |
|TERMINAL (d)       |        6/23 (26%)       19/40 (48%)      16/35 (46%)      15/37 (41%)      11/40 (28%)                      |
|FIRST INCIDENCE    |        571              513              85               611              718                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.006N**       P=0.378N         P=0.383N         P=0.334N         P=0.018N*                        |
|POLY 3             |        P=0.047N*        P=0.246          P=0.341          P=0.406          P=0.164N                         |
|POLY 1.5           |        P=0.058N         P=0.227          P=0.338          P=0.375          P=0.184N                         |
|POLY 6             |        P=0.033N*        P=0.281          P=0.356          P=0.458          P=0.132N                         |
|LOGISTIC REGRESSION|        P=0.077N         P=0.175          P=0.337          P=0.258          P=0.250N                         |
|COCH-ARM / FISHERS |        P=0.073N         P=0.206          P=0.339          P=0.339          P=0.207N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 59
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        2/50 (4%)        1/50 (2%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             4.5%             4.7%             2.3%             4.9%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        645              597              699              593              607                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.554N         P=0.637N         P=0.645N         P=0.453N         P=0.673N                         |
|POLY 3             |        P=0.552N         P=0.668N         P=0.681N         P=0.476N         P=0.694                          |
|POLY 1.5           |        P=0.553N         P=0.679N         P=0.687N         P=0.488N         P=0.690                          |
|POLY 6             |        P=0.549N         P=0.654N         P=0.671N         P=0.460N         P=0.691N                         |
|LOGISTIC REGRESSION|        P=0.515N         P=0.645          P=0.691N         P=0.511N         P=0.688N                         |
|COCH-ARM / FISHERS |        P=0.549N         P=0.691N         P=0.691N         P=0.500N         P=0.691N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             2.1%             2.2%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        702              645              571              ---              724                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.521N         P=0.722N         P=0.737N         P=0.444N         P=0.649N                         |
|POLY 3             |        P=0.565N         P=0.742N         P=0.749N         P=0.483N         P=0.740N                         |
|POLY 1.5           |        P=0.571N         P=0.751N         P=0.756N         P=0.491N         P=0.752N                         |
|POLY 6             |        P=0.558N         P=0.726N         P=0.735N         P=0.470N         P=0.718N                         |
|LOGISTIC REGRESSION|        P=0.624N         P=0.735          P=0.747N         P=0.500N         P=0.752N                         |
|COCH-ARM / FISHERS |        P=0.578N         P=0.753N         P=0.753N         P=0.500N         P=0.747                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 60
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        4/50 (8%)        21/50 (42%)      13/50 (26%)      29/50 (58%)                      |
|POLY-3 ADJUSTED (b)|        0.0%             9.2%             47.5%            29.3%            64.1%                            |
|TERMINAL (d)       |        0/22 (0%)        4/23 (17%)       15/22 (68%)      12/26 (46%)      18/22 (82%)                      |
|FIRST INCIDENCE    |        ---              729 (T)          477              537              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P=0.066          P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 3             |        P<0.001 **       P=0.069          P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.065          P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P=0.074          P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.066          P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.059          P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        18/50 (36%)      23/50 (46%)      19/50 (38%)      26/49 (53%)                      |
|POLY-3 ADJUSTED (b)|        0.0%             38.7%            49.9%            40.4%            55.0%                            |
|TERMINAL (d)       |        0/23 (0%)        18/40 (45%)      21/35 (60%)      19/37 (51%)      25/40 (63%)                      |
|FIRST INCIDENCE    |        ---              730 (T)          85               730 (T)          722                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 61
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        2/50 (4%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             0.0%             4.5%             2.4%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              724              ---              583              603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.301          P=0.523          (e)              P=0.290          P=0.514                          |
|POLY 3             |        P=0.292          P=0.514          (e)              P=0.257          P=0.502                          |
|POLY 1.5           |        P=0.292          P=0.508          (e)              P=0.247          P=0.499                          |
|POLY 6             |        P=0.292          P=0.522          (e)              P=0.271          P=0.506                          |
|LOGISTIC REGRESSION|        P=0.328          P=0.529          (e)              P=0.230          P=0.529                          |
|COCH-ARM / FISHERS |        P=0.301          P=0.500          (e)              P=0.247          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              722              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.686          (e)              (e)              P=0.610          (e)                              |
|POLY 3             |        P=0.672          (e)              (e)              P=0.518          (e)                              |
|POLY 1.5           |        P=0.657          (e)              (e)              P=0.510          (e)                              |
|POLY 6             |        P=0.695          (e)              (e)              P=0.531          (e)                              |
|LOGISTIC REGRESSION|        P=0.663          (e)              (e)              P=0.552          (e)                              |
|COCH-ARM / FISHERS |        P=0.639          (e)              (e)              P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 62
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)        1/50 (2%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             4.6%             2.3%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              718              603              628              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.437N         P=0.531          P=0.270          P=0.524          (e)                              |
|POLY 3             |        P=0.437N         P=0.514          P=0.251          P=0.516          (e)                              |
|POLY 1.5           |        P=0.441N         P=0.508          P=0.244          P=0.508          (e)                              |
|POLY 6             |        P=0.431N         P=0.522          P=0.262          P=0.527          (e)                              |
|LOGISTIC REGRESSION|        P=0.417N         P=0.528          P=0.233          P=0.498          (e)                              |
|COCH-ARM / FISHERS |        P=0.437N         P=0.500          P=0.247          P=0.500          (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/48 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.173          (e)              (e)              (e)              P=0.610                          |
|POLY 3             |        P=0.150          (e)              (e)              (e)              P=0.517                          |
|POLY 1.5           |        P=0.145          (e)              (e)              (e)              P=0.505                          |
|POLY 6             |        P=0.156          (e)              (e)              (e)              P=0.536                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.610                          |
|COCH-ARM / FISHERS |        P=0.140          (e)              (e)              (e)              P=0.490                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 63
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        2/50 (4%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             4.5%             4.8%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              699              628              638                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.068          (e)              P=0.548          P=0.272          P=0.248                          |
|POLY 3             |        P=0.071          (e)              P=0.510          P=0.255          P=0.240                          |
|POLY 1.5           |        P=0.071          (e)              P=0.505          P=0.246          P=0.236                          |
|POLY 6             |        P=0.071          (e)              P=0.518          P=0.269          P=0.245                          |
|LOGISTIC REGRESSION|        P=0.080          (e)              P=0.511          P=0.235          P=0.246                          |
|COCH-ARM / FISHERS |        P=0.075          (e)              P=0.500          P=0.247          P=0.247                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 64
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        11/50 (22%)      13/50 (26%)      13/50 (26%)      8/50 (16%)       14/50 (28%)                      |
|POLY-3 ADJUSTED (b)|        25.8%            28.4%            29.7%            18.2%            31.6%                            |
|TERMINAL (d)       |        5/22 (23%)       4/23 (17%)       6/22 (27%)       5/26 (19%)       5/22 (23%)                       |
|FIRST INCIDENCE    |        537              477              603              705              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.408          P=0.516          P=0.459          P=0.200N         P=0.338                          |
|POLY 3             |        P=0.426          P=0.489          P=0.438          P=0.275N         P=0.361                          |
|POLY 1.5           |        P=0.414          P=0.454          P=0.421          P=0.291N         P=0.337                          |
|POLY 6             |        P=0.433          P=0.536          P=0.464          P=0.256N         P=0.388                          |
|LOGISTIC REGRESSION|        P=0.411          P=0.391          P=0.444          P=0.247N         P=0.335                          |
|COCH-ARM / FISHERS |        P=0.414          P=0.408          P=0.408          P=0.306N         P=0.322                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        13/50 (26%)      18/50 (36%)      19/50 (38%)      21/50 (42%)      24/48 (50%)                      |
|POLY-3 ADJUSTED (b)|        29.6%            37.7%            40.3%            44.6%            50.2%                            |
|TERMINAL (d)       |        9/23 (39%)       14/40 (35%)      12/35 (34%)      18/37 (49%)      19/40 (48%)                      |
|FIRST INCIDENCE    |        617              592              570              722              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.211          P=0.425N         P=0.516          P=0.547          P=0.431                          |
|POLY 3             |        P=0.029 *        P=0.274          P=0.197          P=0.100          P=0.033 *                        |
|POLY 1.5           |        P=0.019 *        P=0.233          P=0.161          P=0.084          P=0.020 *                        |
|POLY 6             |        P=0.050          P=0.355          P=0.270          P=0.134          P=0.068                          |
|LOGISTIC REGRESSION|        P=0.025 *        P=0.284          P=0.152          P=0.265          P=0.044 *                        |
|COCH-ARM / FISHERS |        P=0.011 *        P=0.194          P=0.142          P=0.069          P=0.012 *                        |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 65
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        3/50 (6%)        7/50 (14%)       6/50 (12%)                       |
|POLY-3 ADJUSTED (b)|        2.4%             4.6%             7.0%             15.5%            14.3%                            |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        681              676              699              620              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.017 *        P=0.549          P=0.358          P=0.067          P=0.075                          |
|POLY 3             |        P=0.016 *        P=0.525          P=0.321          P=0.042 *        P=0.059                          |
|POLY 1.5           |        P=0.015 *        P=0.514          P=0.313          P=0.036 *        P=0.056                          |
|POLY 6             |        P=0.017 *        P=0.540          P=0.334          P=0.052          P=0.064                          |
|LOGISTIC REGRESSION|        P=0.017 *        P=0.509          P=0.333          P=0.030 *        P=0.058                          |
|COCH-ARM / FISHERS |        P=0.018 *        P=0.500          P=0.309          P=0.030 *        P=0.056                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 66
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        6/50 (12%)       4/50 (8%)        5/50 (10%)       5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        7.3%             13.7%            9.4%             11.3%            12.2%                            |
|TERMINAL (d)       |        1/22 (5%)        5/23 (22%)       4/22 (18%)       2/26 (8%)        3/22 (14%)                       |
|FIRST INCIDENCE    |        648              718              729 (T)          593              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.411          P=0.286          P=0.524          P=0.471          P=0.368                          |
|POLY 3             |        P=0.396          P=0.271          P=0.520          P=0.398          P=0.351                          |
|POLY 1.5           |        P=0.395          P=0.259          P=0.510          P=0.378          P=0.349                          |
|POLY 6             |        P=0.399          P=0.286          P=0.534          P=0.428          P=0.355                          |
|LOGISTIC REGRESSION|        P=0.387          P=0.310          P=0.554          P=0.373          P=0.361                          |
|COCH-ARM / FISHERS |        P=0.410          P=0.243          P=0.500          P=0.357          P=0.357                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        44/50 (88%)      50/50 (100%)     48/50 (96%)      47/50 (94%)      48/48 (100%)                     |
|POLY-3 ADJUSTED (b)|        92.2%            100.0%           98.0%            95.2%            100.0%                           |
|TERMINAL (d)       |        23/23 (100%)     40/40 (100%)     34/35 (97%)      36/37 (97%)      40/40 (100%)                     |
|FIRST INCIDENCE    |        571              513              506              550              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.008N**       P=0.010N*        P=0.052N         P=0.009N**       P<0.001N**                       |
|POLY 3             |        P=0.118          P=0.031 *        P=0.162          P=0.412          P=0.035 *                        |
|POLY 1.5           |        P=0.079          P=0.021 *        P=0.102          P=0.321          P=0.024 *                        |
|POLY 6             |        P=0.217          P=0.075          P=0.358          P=0.599          P=0.082                          |
|LOGISTIC REGRESSION|        P=0.143          P=0.023 *        P=0.077          P=0.588          P=0.107                          |
|COCH-ARM / FISHERS |        P=0.054          P=0.013 *        P=0.134          P=0.243          P=0.015 *                        |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 67
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             4.5%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        631              ---              ---              583              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.577N         P=0.471N         P=0.485N         P=0.543          P=0.495N                         |
|POLY 3             |        P=0.597N         P=0.488N         P=0.492N         P=0.526          P=0.502N                         |
|POLY 1.5           |        P=0.591N         P=0.493N         P=0.496N         P=0.513          P=0.503N                         |
|POLY 6             |        P=0.605N         P=0.481N         P=0.487N         P=0.544          P=0.501N                         |
|LOGISTIC REGRESSION|        P=0.549N         P=0.541N         P=0.501N         P=0.487          P=0.486N                         |
|COCH-ARM / FISHERS |        P=0.577N         P=0.500N         P=0.500N         P=0.500          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        713              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.323N         P=0.424N         P=0.439N         P=0.429N         P=0.410N                         |
|POLY 3             |        P=0.384N         P=0.485N         P=0.491N         P=0.483N         P=0.483N                         |
|POLY 1.5           |        P=0.374N         P=0.492N         P=0.497N         P=0.491N         P=0.495N                         |
|POLY 6             |        P=0.403N         P=0.472N         P=0.480N         P=0.469N         P=0.464N                         |
|LOGISTIC REGRESSION|        P=0.352N         P=0.476N         P=0.482N         P=0.474N         P=0.485N                         |
|COCH-ARM / FISHERS |        P=0.363N         P=0.500N         P=0.500N         P=0.500N         P=0.510N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 68
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        9/50 (18%)       9/50 (18%)       7/50 (14%)       3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        7.3%             20.3%            20.7%            15.9%            7.4%                             |
|TERMINAL (d)       |        2/22 (9%)        4/23 (17%)       5/22 (23%)       6/26 (23%)       2/22 (9%)                        |
|FIRST INCIDENCE    |        562              669              603              637              682                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.209N         P=0.093          P=0.078          P=0.223          P=0.655N                         |
|POLY 3             |        P=0.224N         P=0.074          P=0.070          P=0.184          P=0.658                          |
|POLY 1.5           |        P=0.226N         P=0.068          P=0.065          P=0.170          P=0.655                          |
|POLY 6             |        P=0.220N         P=0.085          P=0.080          P=0.205          P=0.663                          |
|LOGISTIC REGRESSION|        P=0.222N         P=0.082          P=0.070          P=0.195          P=0.663                          |
|COCH-ARM / FISHERS |        P=0.213N         P=0.061          P=0.061          P=0.159          P=0.661N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        7/50 (14%)       2/50 (4%)        5/50 (10%)       0/48 (0%)                        |
|POLY-3 ADJUSTED (b)|        7.0%             15.0%            4.4%             10.6%            0.0%                             |
|TERMINAL (d)       |        2/23 (9%)        6/40 (15%)       1/35 (3%)        4/37 (11%)       0/40 (0%)                        |
|FIRST INCIDENCE    |        718              718              625              635              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.022N*        P=0.446          P=0.351N         P=0.597          P=0.046N*                        |
|POLY 3             |        P=0.036N*        P=0.190          P=0.476N         P=0.410          P=0.104N                         |
|POLY 1.5           |        P=0.044N*        P=0.174          P=0.492N         P=0.385          P=0.114N                         |
|POLY 6             |        P=0.026N*        P=0.221          P=0.448N         P=0.451          P=0.090N                         |
|LOGISTIC REGRESSION|        P=0.039N*        P=0.344          P=0.482N         P=0.452          P=0.056N                         |
|COCH-ARM / FISHERS |        P=0.058N         P=0.159          P=0.500N         P=0.357          P=0.129N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 69
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/50 (16%)       2/50 (4%)        2/47 (4%)        1/50 (2%)        4/47 (9%)                        |
|POLY-3 ADJUSTED (b)|        18.9%            4.6%             4.9%             2.3%             10.1%                            |
|TERMINAL (d)       |        4/22 (18%)       1/23 (4%)        0/22 (0%)        1/26 (4%)        2/22 (9%)                        |
|FIRST INCIDENCE    |        499              708              620              729 (T)          484                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.272N         P=0.041N*        P=0.047N*        P=0.012N*        P=0.192N                         |
|POLY 3             |        P=0.292N         P=0.038N*        P=0.047N*        P=0.013N*        P=0.208N                         |
|POLY 1.5           |        P=0.291N         P=0.042N*        P=0.052N         P=0.014N*        P=0.214N                         |
|POLY 6             |        P=0.293N         P=0.034N*        P=0.041N*        P=0.011N*        P=0.198N                         |
|LOGISTIC REGRESSION|        P=0.262N         P=0.051N         P=0.064N         P=0.019N*        P=0.198N                         |
|COCH-ARM / FISHERS |        P=0.286N         P=0.046N*        P=0.056N         P=0.015N*        P=0.210N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/49 (4%)        0/49 (0%)        2/50 (4%)        1/48 (2%)        0/47 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             4.4%             2.2%             0.0%                             |
|TERMINAL (d)       |        2/23 (9%)        0/39 (0%)        1/35 (3%)        0/36 (0%)        0/38 (0%)                        |
|FIRST INCIDENCE    |        730 (T)          ---              638              550              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.180N         P=0.132N         P=0.573N         P=0.397N         P=0.136N                         |
|POLY 3             |        P=0.211N         P=0.220N         P=0.667N         P=0.469N         P=0.219N                         |
|POLY 1.5           |        P=0.217N         P=0.228N         P=0.680N         P=0.487N         P=0.231N                         |
|POLY 6             |        P=0.203N         P=0.206N         P=0.643N         P=0.442N         P=0.200N                         |
|LOGISTIC REGRESSION|        P=0.253N         (e)              P=0.673N         P=0.621N         (e)                              |
|COCH-ARM / FISHERS |        P=0.226N         P=0.247N         P=0.684N         P=0.508N         P=0.258N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 70
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        0/47 (0%)        1/50 (2%)        3/47 (6%)                        |
|POLY-3 ADJUSTED (b)|        7.4%             4.6%             0.0%             2.3%             7.5%                             |
|TERMINAL (d)       |        3/22 (14%)       1/23 (4%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        729 (T)          705              ---              674              537                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.457          P=0.465N         P=0.118N         P=0.246N         P=0.654N                         |
|POLY 3             |        P=0.437          P=0.467N         P=0.119N         P=0.278N         P=0.653                          |
|POLY 1.5           |        P=0.435          P=0.482N         P=0.124N         P=0.291N         P=0.639                          |
|POLY 6             |        P=0.440          P=0.447N         P=0.110N         P=0.258N         P=0.654N                         |
|LOGISTIC REGRESSION|        P=0.449          P=0.433N         (e)              P=0.248N         P=0.643                          |
|COCH-ARM / FISHERS |        P=0.439          P=0.500N         P=0.133N         P=0.309N         P=0.631                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/49 (0%)        1/49 (2%)        1/50 (2%)        0/48 (0%)        1/47 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             2.2%             0.0%             2.2%                             |
|TERMINAL (d)       |        0/23 (0%)        0/39 (0%)        0/35 (0%)        0/36 (0%)        1/38 (3%)                        |
|FIRST INCIDENCE    |        ---              589              638              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.530          P=0.508          P=0.509          (e)              P=0.600                          |
|POLY 3             |        P=0.522          P=0.518          P=0.515          (e)              P=0.517                          |
|POLY 1.5           |        P=0.505          P=0.509          P=0.508          (e)              P=0.505                          |
|POLY 6             |        P=0.548          P=0.532          P=0.528          (e)              P=0.536                          |
|LOGISTIC REGRESSION|        P=0.430          P=0.487          P=0.523          (e)              P=0.600                          |
|COCH-ARM / FISHERS |        P=0.485          P=0.500          P=0.505          (e)              P=0.490                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 71
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/49 (0%)        1/50 (2%)        1/50 (2%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             2.3%             2.3%             4.8%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        1/22 (5%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        562              ---              729 (T)          729 (T)          61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.380          P=0.213N         P=0.482N         P=0.449N         P=0.690                          |
|POLY 3             |        P=0.375          P=0.229N         P=0.489N         P=0.480N         P=0.694N                         |
|POLY 1.5           |        P=0.377          P=0.234N         P=0.495N         P=0.490N         P=0.691                          |
|POLY 6             |        P=0.372          P=0.222N         P=0.480N         P=0.466N         P=0.688N                         |
|LOGISTIC REGRESSION|        P=0.559          P=0.281N         P=0.506N         P=0.510N         P=0.531N                         |
|COCH-ARM / FISHERS |        P=0.382          P=0.253N         P=0.500N         P=0.500N         P=0.684                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/49 (2%)        0/49 (0%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             2.2%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        666              730 (T)          ---              ---              724                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.586N         P=0.678N         P=0.474N         P=0.460N         P=0.662N                         |
|POLY 3             |        P=0.652N         P=0.748N         P=0.496N         P=0.483N         P=0.740N                         |
|POLY 1.5           |        P=0.653N         P=0.757N         P=0.502N         P=0.491N         P=0.752N                         |
|POLY 6             |        P=0.652N         P=0.734N         P=0.486N         P=0.471N         P=0.720N                         |
|LOGISTIC REGRESSION|        P=0.656N         P=0.758          P=0.498N         P=0.567N         P=0.744                          |
|COCH-ARM / FISHERS |        P=0.657N         P=0.747          P=0.505N         P=0.500N         P=0.747                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 72
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        5/49 (10%)       7/50 (14%)       7/50 (14%)       7/49 (14%)                       |
|POLY-3 ADJUSTED (b)|        7.1%             11.4%            16.3%            16.0%            17.4%                            |
|TERMINAL (d)       |        0/22 (0%)        2/23 (9%)        5/22 (23%)       6/26 (23%)       6/22 (27%)                       |
|FIRST INCIDENCE    |        565              597              663              717              667                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.155          P=0.427          P=0.187          P=0.232          P=0.169                          |
|POLY 3             |        P=0.130          P=0.378          P=0.165          P=0.173          P=0.137                          |
|POLY 1.5           |        P=0.136          P=0.364          P=0.161          P=0.165          P=0.139                          |
|POLY 6             |        P=0.122          P=0.397          P=0.171          P=0.184          P=0.134                          |
|LOGISTIC REGRESSION|        P=0.141          P=0.268          P=0.160          P=0.167          P=0.148                          |
|COCH-ARM / FISHERS |        P=0.155          P=0.346          P=0.159          P=0.159          P=0.151                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/49 (2%)        1/49 (2%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             2.2%             2.3%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/23 (4%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        730 (T)          606              730 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.172N         P=0.698N         P=0.665N         P=0.405N         P=0.390N                         |
|POLY 3             |        P=0.200N         P=0.745N         P=0.756N         P=0.482N         P=0.481N                         |
|POLY 1.5           |        P=0.204N         P=0.755N         P=0.759          P=0.491N         P=0.492N                         |
|POLY 6             |        P=0.195N         P=0.727N         P=0.743N         P=0.469N         P=0.463N                         |
|LOGISTIC REGRESSION|        P=0.217N         P=0.725          P=0.665N         (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.209N         P=0.747          P=0.747          P=0.500N         P=0.505N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 73
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/49 (2%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             2.3%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        485              669              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.105N         P=0.483N         P=0.244N         P=0.224N         P=0.249N                         |
|POLY 3             |        P=0.106N         P=0.486N         P=0.230N         P=0.225N         P=0.245N                         |
|POLY 1.5           |        P=0.106N         P=0.496N         P=0.234N         P=0.231N         P=0.246N                         |
|POLY 6             |        P=0.106N         P=0.472N         P=0.224N         P=0.215N         P=0.242N                         |
|LOGISTIC REGRESSION|        P=0.085N         P=0.583N         P=0.225N         P=0.229N         P=0.207N                         |
|COCH-ARM / FISHERS |        P=0.107N         P=0.508N         P=0.247N         P=0.247N         P=0.253N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/49 (0%)        0/49 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 74
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/45 (0%)        1/47 (2%)        0/46 (0%)        0/50 (0%)        0/47 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/21 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              724              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.507N         P=0.523          (e)              (e)              (e)                              |
|POLY 3             |        P=0.475N         P=0.520          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.482N         P=0.515          (e)              (e)              (e)                              |
|POLY 6             |        P=0.468N         P=0.524          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.499N         P=0.519          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.491N         P=0.511          (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       3/50 (6%)        4/50 (8%)        2/50 (4%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        11.4%            6.4%             8.9%             4.2%             2.1%                             |
|TERMINAL (d)       |        2/23 (9%)        2/40 (5%)        4/35 (11%)       1/37 (3%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        550              679              730 (T)          550              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.034N*        P=0.181N         P=0.306N         P=0.123N         P=0.038N*                        |
|POLY 3             |        P=0.056N         P=0.323N         P=0.484N         P=0.184N         P=0.082N                         |
|POLY 1.5           |        P=0.061N         P=0.340N         P=0.498N         P=0.199N         P=0.091N                         |
|POLY 6             |        P=0.050N         P=0.293N         P=0.457N         P=0.163N         P=0.068N                         |
|LOGISTIC REGRESSION|        P=0.071N         P=0.383N         P=0.490N         P=0.352N         P=0.134N                         |
|COCH-ARM / FISHERS |        P=0.067N         P=0.357N         P=0.500N         P=0.218N         P=0.102N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 75
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        10/45 (22%)      21/47 (45%)      12/46 (26%)      12/50 (24%)      10/47 (21%)                      |
|POLY-3 ADJUSTED (b)|        26.5%            49.0%            29.4%            26.8%            25.6%                            |
|TERMINAL (d)       |        7/22 (32%)       10/21 (48%)      4/21 (19%)       7/26 (27%)       6/22 (27%)                       |
|FIRST INCIDENCE    |        537              615              638              537              638                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.150N         P=0.029 *        P=0.438          P=0.584          P=0.590                          |
|POLY 3             |        P=0.122N         P=0.028 *        P=0.487          P=0.588          P=0.569N                         |
|POLY 1.5           |        P=0.125N         P=0.023 *        P=0.455          P=0.552          P=0.574N                         |
|POLY 6             |        P=0.119N         P=0.039 *        P=0.537          P=0.566N         P=0.562N                         |
|LOGISTIC REGRESSION|        P=0.130N         P=0.030 *        P=0.478          P=0.591          P=0.562N                         |
|COCH-ARM / FISHERS |        P=0.118N         P=0.019 *        P=0.427          P=0.516          P=0.556N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        23/50 (46%)      8/50 (16%)       11/50 (22%)      5/50 (10%)       5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        49.7%            16.8%            23.6%            10.5%            10.3%                            |
|TERMINAL (d)       |        8/23 (35%)       6/40 (15%)       6/35 (17%)       1/37 (3%)        2/40 (5%)                        |
|FIRST INCIDENCE    |        571              513              571              635              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P<0.001N**       P=0.002N**       P<0.001N**       P<0.001N**                       |
|POLY 3             |        P<0.001N**       P<0.001N**       P=0.006N**       P<0.001N**       P<0.001N**                       |
|POLY 1.5           |        P<0.001N**       P<0.001N**       P=0.008N**       P<0.001N**       P<0.001N**                       |
|POLY 6             |        P<0.001N**       P<0.001N**       P=0.004N**       P<0.001N**       P<0.001N**                       |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.002N**       P=0.010N*        P<0.001N**       P<0.001N**                       |
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001N**       P=0.010N*        P<0.001N**       P<0.001N**                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 76
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/10 (20%)       0/4 (0%)         0/6 (0%)         0/7 (0%)         0/6 (0%)                         |
|POLY-3 ADJUSTED (b)|        23.8%            0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/1 (0%)         0/4 (0%)         0/1 (0%)                         |
|FIRST INCIDENCE    |        562              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.155N         P=0.214N         P=0.224N         P=0.219N         P=0.238N                         |
|POLY 3             |        P=0.177N         P=0.422N         P=0.348N         P=0.297N         P=0.352N                         |
|POLY 1.5           |        P=0.177N         P=0.438N         P=0.350N         P=0.305N         P=0.351N                         |
|POLY 6             |        P=0.174N         P=0.392N         P=0.344N         P=0.277N         P=0.353N                         |
|LOGISTIC REGRESSION|        P=0.221N         P=0.960N         P=0.498N         P=0.399N         P=0.502N                         |
|COCH-ARM / FISHERS |        P=0.177N         P=0.495N         P=0.375N         P=0.331N         P=0.375N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/4 (0%)         0/4 (0%)         1/6 (17%)        0/3 (0%)         0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             16.8%            0.0%             0.0%                             |
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/4 (0%)         0/2 (0%)         0/2 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              703              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.607N         (e)              P=0.573          (e)              (e)                              |
|POLY 3             |        P=0.756N         (e)              P=0.621          (e)              (e)                              |
|POLY 1.5           |        P=0.759N         (e)              P=0.603          (e)              (e)                              |
|POLY 6             |        P=0.751N         (e)              P=0.649          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.778N         (e)              P=0.616          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.781N         (e)              P=0.600          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 77
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/10 (0%)        0/4 (0%)         0/6 (0%)         0/7 (0%)         2/6 (33%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             37.8%                            |
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/1 (0%)         0/4 (0%)         0/1 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              ---              671                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.019 *        (e)              (e)              (e)              P=0.250                          |
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              P=0.124                          |
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              P=0.114                          |
|POLY 6             |        P=0.010 *        (e)              (e)              (e)              P=0.148                          |
|LOGISTIC REGRESSION|        P=0.015 *        (e)              (e)              (e)              P=0.144                          |
|COCH-ARM / FISHERS |        P=0.016 *        (e)              (e)              (e)              P=0.125                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/4 (0%)         0/4 (0%)         0/6 (0%)         0/3 (0%)         0/2 (0%)                         |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/4 (0%)         0/2 (0%)         0/2 (0%)                         |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 78
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/10 (60%)       3/4 (75%)        2/6 (33%)        2/7 (29%)        4/6 (67%)                        |
|POLY-3 ADJUSTED (b)|        68.4%            80.0%            38.6%            32.6%            70.7%                            |
|TERMINAL (d)       |        0/1 (0%)         3/3 (100%)       1/1 (100%)       2/4 (50%)        1/1 (100%)                       |
|FIRST INCIDENCE    |        642              729 (T)          687              729 (T)          603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.451N         P=0.073N         P=0.119N         P=0.038N*        P=0.373N                         |
|POLY 3             |        P=0.546N         P=0.611          P=0.291N         P=0.189N         P=0.693                          |
|POLY 1.5           |        P=0.558N         P=0.574          P=0.297N         P=0.202N         P=0.650                          |
|POLY 6             |        P=0.530N         P=0.668          P=0.295N         P=0.173N         P=0.752                          |
|LOGISTIC REGRESSION|        P=0.501N         P=0.662N         P=0.193N         P=0.111N         P=0.698                          |
|COCH-ARM / FISHERS |        P=0.573N         P=0.545          P=0.304N         P=0.218N         P=0.608                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/4 (75%)        4/4 (100%)       4/6 (67%)        2/3 (67%)        2/2 (100%)                       |
|POLY-3 ADJUSTED (b)|        77.1%            100.0%           68.4%            77.3%            100.0%                           |
|TERMINAL (d)       |        1/1 (100%)       3/3 (100%)       4/4 (100%)       2/2 (100%)       2/2 (100%)                       |
|FIRST INCIDENCE    |        571              513              730 (T)          730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.097N         P=0.468N         P=0.214N         P=0.203N         P=0.193N                         |
|POLY 3             |        P=0.561          P=0.542          P=0.657N         P=0.808          P=0.668                          |
|POLY 1.5           |        P=0.564          P=0.520          P=0.652N         P=0.758N         P=0.649                          |
|POLY 6             |        P=0.568          P=0.588          P=0.666N         P=0.802          P=0.707                          |
|LOGISTIC REGRESSION|        P=0.633          P=0.470          P=0.769N         P=0.700N         P=0.601                          |
|COCH-ARM / FISHERS |        P=0.578          P=0.500          P=0.667N         P=0.714N         P=0.667                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 79
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        3/50 (6%)        7/50 (14%)       5/50 (10%)       6/50 (12%)                       |
|POLY-3 ADJUSTED (b)|        9.7%             6.7%             16.0%            11.3%            14.1%                            |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        2/22 (9%)        3/26 (12%)       1/22 (5%)                        |
|FIRST INCIDENCE    |        645              477              565              628              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.270          P=0.447N         P=0.320          P=0.595          P=0.398                          |
|POLY 3             |        P=0.262          P=0.456N         P=0.293          P=0.545          P=0.384                          |
|POLY 1.5           |        P=0.260          P=0.475N         P=0.277          P=0.523          P=0.373                          |
|POLY 6             |        P=0.266          P=0.435N         P=0.316          P=0.574          P=0.399                          |
|LOGISTIC REGRESSION|        P=0.307          P=0.585N         P=0.263          P=0.507          P=0.385                          |
|COCH-ARM / FISHERS |        P=0.270          P=0.500N         P=0.262          P=0.500          P=0.370                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        1/50 (2%)        1/50 (2%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        9.3%             2.2%             2.2%             0.0%             2.1%                             |
|TERMINAL (d)       |        4/23 (17%)       1/40 (3%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        730 (T)          730 (T)          570              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.092N         P=0.054N         P=0.095N         P=0.019N*        P=0.054N                         |
|POLY 3             |        P=0.137N         P=0.156N         P=0.162N         P=0.050N         P=0.147N                         |
|POLY 1.5           |        P=0.136N         P=0.167N         P=0.173N         P=0.055N         P=0.162N                         |
|POLY 6             |        P=0.141N         P=0.138N         P=0.143N         P=0.043N*        P=0.124N                         |
|LOGISTIC REGRESSION|        P=0.132N         P=0.054N         P=0.177N         (e)              P=0.054N                         |
|COCH-ARM / FISHERS |        P=0.137N         P=0.181N         P=0.181N         P=0.059N         P=0.181N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 80
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        3/50 (6%)        8/50 (16%)       6/50 (12%)       6/50 (12%)                       |
|POLY-3 ADJUSTED (b)|        9.7%             6.7%             18.2%            13.5%            14.3%                            |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        2/22 (9%)        3/26 (12%)       1/22 (5%)                        |
|FIRST INCIDENCE    |        645              477              565              628              603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.279          P=0.447N         P=0.238          P=0.482          P=0.403                          |
|POLY 3             |        P=0.260          P=0.456N         P=0.206          P=0.417          P=0.379                          |
|POLY 1.5           |        P=0.259          P=0.475N         P=0.192          P=0.393          P=0.368                          |
|POLY 6             |        P=0.266          P=0.435N         P=0.229          P=0.449          P=0.395                          |
|LOGISTIC REGRESSION|        P=0.298          P=0.585N         P=0.178          P=0.377          P=0.370                          |
|COCH-ARM / FISHERS |        P=0.276          P=0.500N         P=0.178          P=0.370          P=0.370                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        2/50 (4%)        1/50 (2%)        1/50 (2%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        9.2%             4.3%             2.2%             2.1%             2.1%                             |
|TERMINAL (d)       |        3/23 (13%)       2/40 (5%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        617              730 (T)          703              701              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.086N         P=0.155N         P=0.102N         P=0.092N         P=0.072N                         |
|POLY 3             |        P=0.129N         P=0.306N         P=0.167N         P=0.155N         P=0.149N                         |
|POLY 1.5           |        P=0.132N         P=0.321N         P=0.176N         P=0.166N         P=0.163N                         |
|POLY 6             |        P=0.125N         P=0.280N         P=0.151N         P=0.137N         P=0.128N                         |
|LOGISTIC REGRESSION|        P=0.125N         P=0.290N         P=0.173N         P=0.173N         P=0.158N                         |
|COCH-ARM / FISHERS |        P=0.137N         P=0.339N         P=0.181N         P=0.181N         P=0.181N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 81
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             7.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        565              ---              ---              ---              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.037 *        P=0.483N         P=0.487N         P=0.483N         P=0.301                          |
|POLY 3             |        P=0.036 *        P=0.489N         P=0.493N         P=0.488N         P=0.318                          |
|POLY 1.5           |        P=0.036 *        P=0.494N         P=0.497N         P=0.494N         P=0.310                          |
|POLY 6             |        P=0.036 *        P=0.482N         P=0.488N         P=0.480N         P=0.327                          |
|LOGISTIC REGRESSION|        P=0.112          P=0.566N         P=0.464N         P=0.469N         P=0.462                          |
|COCH-ARM / FISHERS |        P=0.038 *        P=0.500N         P=0.500N         P=0.500N         P=0.309                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              570              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.651N         (e)              P=0.496          (e)              (e)                              |
|POLY 3             |        P=0.639N         (e)              P=0.511          (e)              (e)                              |
|POLY 1.5           |        P=0.644N         (e)              P=0.504          (e)              (e)                              |
|POLY 6             |        P=0.631N         (e)              P=0.524          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.709N         (e)              P=0.563          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.649N         (e)              P=0.500          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 82
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       8/50 (16%)       9/50 (18%)       8/50 (16%)       6/49 (12%)                       |
|POLY-3 ADJUSTED (b)|        11.5%            17.0%            19.8%            16.7%            12.7%                            |
|TERMINAL (d)       |        3/23 (13%)       7/40 (18%)       6/35 (17%)       5/37 (14%)       5/40 (13%)                       |
|FIRST INCIDENCE    |        652              575              652              550              718                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.271N         P=0.601          P=0.431          P=0.550          P=0.417N                         |
|POLY 3             |        P=0.437N         P=0.326          P=0.215          P=0.338          P=0.557                          |
|POLY 1.5           |        P=0.476N         P=0.302          P=0.199          P=0.310          P=0.523                          |
|POLY 6             |        P=0.377N         P=0.370          P=0.247          P=0.386          P=0.613                          |
|LOGISTIC REGRESSION|        P=0.473N         P=0.310          P=0.234          P=0.266          P=0.603                          |
|COCH-ARM / FISHERS |        P=0.523N         P=0.277          P=0.194          P=0.277          P=0.486                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 83
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        26/50 (52%)      30/50 (60%)      25/50 (50%)      28/50 (56%)      24/50 (48%)                      |
|POLY-3 ADJUSTED (b)|        55.3%            63.3%            55.6%            59.5%            54.0%                            |
|TERMINAL (d)       |        7/22 (32%)       13/23 (57%)      11/22 (50%)      15/26 (58%)      12/22 (55%)                      |
|FIRST INCIDENCE    |        537              481              603              583              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.336N         P=0.482          P=0.401N         P=0.421N         P=0.412N                         |
|POLY 3             |        P=0.379N         P=0.279          P=0.575          P=0.418          P=0.534N                         |
|POLY 1.5           |        P=0.351N         P=0.279          P=0.558N         P=0.411          P=0.499N                         |
|POLY 6             |        P=0.424N         P=0.270          P=0.535          P=0.426          P=0.586                          |
|LOGISTIC REGRESSION|        P=0.301N         P=0.218          P=0.494N         P=0.395          P=0.420N                         |
|COCH-ARM / FISHERS |        P=0.277N         P=0.273          P=0.500N         P=0.421          P=0.421N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        21/50 (42%)      27/50 (54%)      16/50 (32%)      22/50 (44%)      9/49 (18%)                       |
|POLY-3 ADJUSTED (b)|        45.7%            56.5%            34.8%            45.6%            19.1%                            |
|TERMINAL (d)       |        11/23 (48%)      23/40 (58%)      12/35 (34%)      18/37 (49%)      9/40 (23%)                       |
|FIRST INCIDENCE    |        550              589              571              550              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.283N         P=0.034N*        P=0.134N         P<0.001N**                       |
|POLY 3             |        P<0.001N**       P=0.199          P=0.193N         P=0.575N         P=0.004N**                       |
|POLY 1.5           |        P<0.001N**       P=0.177          P=0.209N         P=0.549          P=0.006N**                       |
|POLY 6             |        P<0.001N**       P=0.246          P=0.164N         P=0.517N         P=0.002N**                       |
|LOGISTIC REGRESSION|        P<0.001N**       P=0.199          P=0.193N         P=0.505          P=0.009N**                       |
|COCH-ARM / FISHERS |        P=0.002N**       P=0.158          P=0.204N         P=0.500          P=0.009N**                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 84
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        2/50 (4%)        2/50 (4%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.9%             9.2%             4.6%             4.5%             2.4%                             |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       1/22 (5%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        665              724              565              628              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.220N         P=0.372          P=0.679N         P=0.639N         P=0.490N                         |
|POLY 3             |        P=0.222N         P=0.367          P=0.675N         P=0.667N         P=0.500N                         |
|POLY 1.5           |        P=0.226N         P=0.354          P=0.684N         P=0.680N         P=0.504N                         |
|POLY 6             |        P=0.217N         P=0.383          P=0.662N         P=0.648N         P=0.495N                         |
|LOGISTIC REGRESSION|        P=0.226N         P=0.403          P=0.692          P=0.689N         P=0.502N                         |
|COCH-ARM / FISHERS |        P=0.222N         P=0.339          P=0.691N         P=0.691N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        2/50 (4%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.6%             2.2%             0.0%             4.3%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        2/37 (5%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        704              730 (T)          ---              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.444N         P=0.347N         P=0.172N         P=0.531N         P=0.326N                         |
|POLY 3             |        P=0.539N         P=0.474N         P=0.228N         P=0.663N         P=0.469N                         |
|POLY 1.5           |        P=0.547N         P=0.487N         P=0.235N         P=0.677N         P=0.487N                         |
|POLY 6             |        P=0.529N         P=0.452N         P=0.216N         P=0.639N         P=0.439N                         |
|LOGISTIC REGRESSION|        P=0.484N         P=0.440N         P=0.218N         P=0.613N         P=0.438N                         |
|COCH-ARM / FISHERS |        P=0.559N         P=0.500N         P=0.247N         P=0.691N         P=0.508N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 85
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hypertrophy Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        6/50 (12%)       3/50 (6%)        2/50 (4%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             13.7%            7.0%             4.6%             4.9%                             |
|TERMINAL (d)       |        1/22 (5%)        6/23 (26%)       1/22 (5%)        2/26 (8%)        2/22 (9%)                        |
|FIRST INCIDENCE    |        729 (T)          729 (T)          620              729 (T)          729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.340N         P=0.059          P=0.314          P=0.559          P=0.500                          |
|POLY 3             |        P=0.342N         P=0.067          P=0.325          P=0.525          P=0.499                          |
|POLY 1.5           |        P=0.350N         P=0.062          P=0.315          P=0.513          P=0.496                          |
|POLY 6             |        P=0.332N         P=0.073          P=0.341          P=0.543          P=0.504                          |
|LOGISTIC REGRESSION|        P=0.362N         P=0.059          P=0.325          P=0.559          P=0.500                          |
|COCH-ARM / FISHERS |        P=0.349N         P=0.056          P=0.309          P=0.500          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hypertrophy Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             4.3%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        2/40 (5%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        649              730 (T)          ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.420N         P=0.634          P=0.486N         P=0.481N         P=0.678N                         |
|POLY 3             |        P=0.485N         P=0.525          P=0.492N         P=0.484N         P=0.741N                         |
|POLY 1.5           |        P=0.491N         P=0.513          P=0.498N         P=0.491N         P=0.753N                         |
|POLY 6             |        P=0.476N         P=0.546          P=0.482N         P=0.471N         P=0.721N                         |
|LOGISTIC REGRESSION|        P=0.490N         P=0.508          P=0.487N         P=0.594N         P=0.733                          |
|COCH-ARM / FISHERS |        P=0.500N         P=0.500          P=0.500N         P=0.500N         P=0.747                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 86
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        2/50 (4%)        1/50 (2%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.6%             4.7%             2.3%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        2/23 (9%)        2/22 (9%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              729 (T)          729 (T)          729 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.312N         P=0.247          P=0.237          P=0.533          (e)                              |
|POLY 3             |        P=0.317N         P=0.253          P=0.247          P=0.514          (e)                              |
|POLY 1.5           |        P=0.322N         P=0.246          P=0.242          P=0.507          (e)                              |
|POLY 6             |        P=0.310N         P=0.262          P=0.255          P=0.525          (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.247          P=0.237          P=0.533          (e)                              |
|COCH-ARM / FISHERS |        P=0.321N         P=0.247          P=0.247          P=0.500          (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 87
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        3/50 (6%)        1/50 (2%)        5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        2.5%             2.3%             7.0%             2.3%             11.9%                            |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        2/22 (9%)        1/26 (4%)        2/22 (9%)                        |
|FIRST INCIDENCE    |        729 (T)          676              620              729 (T)          421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.040 *        P=0.739N         P=0.312          P=0.725N         P=0.113                          |
|POLY 3             |        P=0.039 *        P=0.744N         P=0.325          P=0.745N         P=0.107                          |
|POLY 1.5           |        P=0.038 *        P=0.751N         P=0.315          P=0.753N         P=0.103                          |
|POLY 6             |        P=0.040 *        P=0.734N         P=0.340          P=0.733N         P=0.113                          |
|LOGISTIC REGRESSION|        P=0.042 *        P=0.744N         P=0.327          P=0.725N         P=0.108                          |
|COCH-ARM / FISHERS |        P=0.039 *        P=0.753N         P=0.309          P=0.753N         P=0.102                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.173          (e)              (e)              (e)              P=0.610                          |
|POLY 3             |        P=0.151          (e)              (e)              (e)              P=0.519                          |
|POLY 1.5           |        P=0.147          (e)              (e)              (e)              P=0.508                          |
|POLY 6             |        P=0.157          (e)              (e)              (e)              P=0.537                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.610                          |
|COCH-ARM / FISHERS |        P=0.142          (e)              (e)              (e)              P=0.495                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 88
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.3%             7.3%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              727              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.006 **       (e)              (e)              P=0.541          P=0.137                          |
|POLY 3             |        P=0.006 **       (e)              (e)              P=0.514          P=0.120                          |
|POLY 1.5           |        P=0.006 **       (e)              (e)              P=0.507          P=0.118                          |
|POLY 6             |        P=0.006 **       (e)              (e)              P=0.525          P=0.125                          |
|LOGISTIC REGRESSION|        P=0.006 **       (e)              (e)              P=0.541          P=0.121                          |
|COCH-ARM / FISHERS |        P=0.006 **       (e)              (e)              P=0.500          P=0.121                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 89
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/49 (10%)       13/48 (27%)      19/48 (40%)      20/50 (40%)      12/45 (27%)                      |
|POLY-3 ADJUSTED (b)|        12.2%            29.3%            43.9%            43.5%            30.5%                            |
|TERMINAL (d)       |        2/22 (9%)        5/23 (22%)       5/22 (23%)       8/26 (31%)       3/21 (14%)                       |
|FIRST INCIDENCE    |        555              642              565              620              537                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.175          P=0.071          P=0.006 **       P=0.007 **       P=0.070                          |
|POLY 3             |        P=0.119          P=0.044 *        P<0.001 **       P<0.001 **       P=0.038 *                        |
|POLY 1.5           |        P=0.105          P=0.037 *        P<0.001 **       P<0.001 **       P=0.034 *                        |
|POLY 6             |        P=0.148          P=0.056          P<0.001 **       P=0.002 **       P=0.047 *                        |
|LOGISTIC REGRESSION|        P=0.103          P=0.040 *        P<0.001 **       P<0.001 **       P=0.035 *                        |
|COCH-ARM / FISHERS |        P=0.117          P=0.029 *        P<0.001 **       P<0.001 **       P=0.035 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/42 (0%)        1/44 (2%)        0/48 (0%)        0/48 (0%)        1/41 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             0.0%             0.0%             2.5%                             |
|TERMINAL (d)       |        0/18 (0%)        0/34 (0%)        0/33 (0%)        0/36 (0%)        0/32 (0%)                        |
|FIRST INCIDENCE    |        ---              589              ---              ---              718                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.443          P=0.508          (e)              (e)              P=0.613                          |
|POLY 3             |        P=0.426          P=0.530          (e)              (e)              P=0.524                          |
|POLY 1.5           |        P=0.412          P=0.520          (e)              (e)              P=0.511                          |
|POLY 6             |        P=0.448          P=0.546          (e)              (e)              P=0.546                          |
|LOGISTIC REGRESSION|        P=0.347          P=0.486          (e)              (e)              P=0.556                          |
|COCH-ARM / FISHERS |        P=0.394          P=0.512          (e)              (e)              P=0.494                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 90
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        0/49 (0%)        1/50 (2%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             2.3%             0.0%             2.3%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        0/22 (0%)        0/26 (0%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        565              729 (T)          ---              583              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.580          P=0.746N         P=0.487N         P=0.736N         P=0.758N                         |
|POLY 3             |        P=0.563          P=0.748N         P=0.497N         P=0.745N         P=0.758                          |
|POLY 1.5           |        P=0.566          P=0.753N         P=0.501N         P=0.753N         P=0.757                          |
|POLY 6             |        P=0.558          P=0.741N         P=0.490N         P=0.734N         P=0.759                          |
|LOGISTIC REGRESSION|        P=0.604          P=0.733          P=0.468N         P=0.753N         P=0.757N                         |
|COCH-ARM / FISHERS |        P=0.577          P=0.753N         P=0.505N         P=0.753N         P=0.753N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        12/50 (24%)      2/50 (4%)        10/49 (20%)      6/49 (12%)                       |
|POLY-3 ADJUSTED (b)|        2.3%             25.8%            4.4%             21.7%            12.5%                            |
|TERMINAL (d)       |        0/23 (0%)        11/40 (28%)      1/35 (3%)        10/36 (28%)      5/40 (13%)                       |
|FIRST INCIDENCE    |        635              718              723              730 (T)          724                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.515          P=0.018 *        P=0.605          P=0.028 *        P=0.177                          |
|POLY 3             |        P=0.367          P<0.001 **       P=0.513          P=0.005 **       P=0.074                          |
|POLY 1.5           |        P=0.316          P<0.001 **       P=0.503          P=0.004 **       P=0.064                          |
|POLY 6             |        P=0.450          P=0.002 **       P=0.531          P=0.007 **       P=0.093                          |
|LOGISTIC REGRESSION|        P=0.478          P=0.004 **       P=0.501          P=0.012 *        P=0.071                          |
|COCH-ARM / FISHERS |        P=0.262          P<0.001 **       P=0.500          P=0.003 **       P=0.053                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 91
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        3/50 (6%)        3/49 (6%)        3/50 (6%)        6/50 (12%)                       |
|POLY-3 ADJUSTED (b)|        4.9%             6.7%             7.1%             6.8%             14.5%                            |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        1/22 (5%)        2/26 (8%)        4/22 (18%)                       |
|FIRST INCIDENCE    |        648              477              666              653              484                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.075          P=0.550          P=0.540          P=0.579          P=0.138                          |
|POLY 3             |        P=0.074          P=0.540          P=0.512          P=0.531          P=0.134                          |
|POLY 1.5           |        P=0.075          P=0.523          P=0.501          P=0.516          P=0.131                          |
|POLY 6             |        P=0.073          P=0.560          P=0.529          P=0.553          P=0.137                          |
|LOGISTIC REGRESSION|        P=0.083          P=0.403          P=0.509          P=0.519          P=0.132                          |
|COCH-ARM / FISHERS |        P=0.079          P=0.500          P=0.490          P=0.500          P=0.134                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        9/50 (18%)       7/50 (14%)       3/50 (6%)        0/49 (0%)        3/49 (6%)                        |
|POLY-3 ADJUSTED (b)|        20.5%            14.9%            6.6%             0.0%             6.2%                             |
|TERMINAL (d)       |        5/23 (22%)       5/40 (13%)       2/35 (6%)        0/36 (0%)        2/40 (5%)                        |
|FIRST INCIDENCE    |        571              592              506              ---              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.006N**       P=0.116N         P=0.020N*        P<0.001N**       P=0.011N*                        |
|POLY 3             |        P=0.012N*        P=0.335N         P=0.050N         P<0.001N**       P=0.040N*                        |
|POLY 1.5           |        P=0.014N*        P=0.363N         P=0.056N         P=0.002N**       P=0.050N                         |
|POLY 6             |        P=0.011N*        P=0.288N         P=0.040N*        P<0.001N**       P=0.027N*                        |
|LOGISTIC REGRESSION|        P=0.022N*        P=0.356N         P=0.062N         P=0.002N**       P=0.107N                         |
|COCH-ARM / FISHERS |        P=0.017N*        P=0.393N         P=0.061N         P<0.001N**       P=0.065N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 92
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        13/50 (26%)      26/50 (52%)      24/49 (49%)      28/50 (56%)      19/50 (38%)                      |
|POLY-3 ADJUSTED (b)|        31.6%            57.1%            55.6%            60.5%            44.8%                            |
|TERMINAL (d)       |        10/22 (46%)      14/23 (61%)      17/22 (77%)      17/26 (65%)      11/22 (50%)                      |
|FIRST INCIDENCE    |        648              597              643              593              537                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.391          P=0.021 *        P=0.020 *        P=0.019 *        P=0.151                          |
|POLY 3             |        P=0.400          P=0.011 *        P=0.018 *        P=0.004 **       P=0.148                          |
|POLY 1.5           |        P=0.374          P=0.008 **       P=0.015 *        P=0.002 **       P=0.136                          |
|POLY 6             |        P=0.445          P=0.018 *        P=0.025 *        P=0.010 *        P=0.173                          |
|LOGISTIC REGRESSION|        P=0.340          P=0.018 *        P=0.032 *        P=0.006 **       P=0.139                          |
|COCH-ARM / FISHERS |        P=0.397          P=0.007 **       P=0.015 *        P=0.002 **       P=0.142                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        24/50 (48%)      27/50 (54%)      21/50 (42%)      26/49 (53%)      32/49 (65%)                      |
|POLY-3 ADJUSTED (b)|        51.0%            56.7%            45.3%            56.3%            65.8%                            |
|TERMINAL (d)       |        11/23 (48%)      23/40 (58%)      17/35 (49%)      24/36 (67%)      27/40 (68%)                      |
|FIRST INCIDENCE    |        571              592              571              689              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.483          P=0.130N         P=0.063N         P=0.129N         P=0.269N                         |
|POLY 3             |        P=0.060          P=0.362          P=0.365N         P=0.381          P=0.100                          |
|POLY 1.5           |        P=0.049 *        P=0.350          P=0.373N         P=0.380          P=0.080                          |
|POLY 6             |        P=0.081          P=0.396          P=0.339N         P=0.387          P=0.140                          |
|LOGISTIC REGRESSION|        P=0.080          P=0.361          P=0.340N         P=0.469          P=0.035 *                        |
|COCH-ARM / FISHERS |        P=0.037 *        P=0.345          P=0.344N         P=0.381          P=0.062                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 93
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/49 (0%)        2/50 (4%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             0.0%             4.6%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        2/26 (8%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        ---              676              ---              729 (T)          729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.303          P=0.530          (e)              P=0.275          P=0.500                          |
|POLY 3             |        P=0.289          P=0.515          (e)              P=0.253          P=0.500                          |
|POLY 1.5           |        P=0.291          P=0.508          (e)              P=0.245          P=0.498                          |
|POLY 6             |        P=0.285          P=0.524          (e)              P=0.265          P=0.502                          |
|LOGISTIC REGRESSION|        P=0.288          P=0.494          (e)              P=0.275          P=0.500                          |
|COCH-ARM / FISHERS |        P=0.302          P=0.500          (e)              P=0.247          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/49 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/36 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          ---              ---              709                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.468          P=0.610          (e)              (e)              P=0.599                          |
|POLY 3             |        P=0.429          P=0.515          (e)              (e)              P=0.521                          |
|POLY 1.5           |        P=0.416          P=0.508          (e)              (e)              P=0.510                          |
|POLY 6             |        P=0.450          P=0.529          (e)              (e)              P=0.540                          |
|LOGISTIC REGRESSION|        P=0.431          P=0.610          (e)              (e)              P=0.504                          |
|COCH-ARM / FISHERS |        P=0.399          P=0.500          (e)              (e)              P=0.495                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 94
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Nervosa                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       1/50 (2%)        0/49 (0%)        4/50 (8%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        12.3%            2.3%             0.0%             9.1%             2.5%                             |
|TERMINAL (d)       |        5/22 (23%)       1/23 (4%)        0/22 (0%)        2/26 (8%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        729 (T)          729 (T)          ---              674              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.239N         P=0.087N         P=0.030N*        P=0.388N         P=0.096N                         |
|POLY 3             |        P=0.269N         P=0.085N         P=0.027N*        P=0.451N         P=0.100N                         |
|POLY 1.5           |        P=0.262N         P=0.092N         P=0.030N*        P=0.476N         P=0.103N                         |
|POLY 6             |        P=0.280N         P=0.076N         P=0.024N*        P=0.415N         P=0.095N                         |
|LOGISTIC REGRESSION|        P=0.254N         P=0.087N         (e)              P=0.379N         P=0.096N                         |
|COCH-ARM / FISHERS |        P=0.247N         P=0.102N         P=0.030N*        P=0.500N         P=0.102N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Nervosa                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/49 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.2%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        1/36 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              730 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.678          (e)              (e)              P=0.589          (e)                              |
|POLY 3             |        P=0.677          (e)              (e)              P=0.513          (e)                              |
|POLY 1.5           |        P=0.660          (e)              (e)              P=0.505          (e)                              |
|POLY 6             |        P=0.702          (e)              (e)              P=0.527          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.589          (e)                              |
|COCH-ARM / FISHERS |        P=0.638          (e)              (e)              P=0.495          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 95
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        4/49 (8%)        3/50 (6%)        0/49 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        7.4%             9.3%             7.0%             0.0%             2.5%                             |
|TERMINAL (d)       |        3/22 (14%)       4/23 (17%)       3/22 (14%)       0/25 (0%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          ---              729 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.070N         P=0.525          P=0.668          P=0.097N         P=0.302N                         |
|POLY 3             |        P=0.076N         P=0.530          P=0.641N         P=0.110N         P=0.305N                         |
|POLY 1.5           |        P=0.078N         P=0.512          P=0.652N         P=0.116N         P=0.309N                         |
|POLY 6             |        P=0.073N         P=0.554          P=0.625N         P=0.101N         P=0.300N                         |
|LOGISTIC REGRESSION|        P=0.070N         P=0.525          P=0.668          (e)              P=0.302N                         |
|COCH-ARM / FISHERS |        P=0.079N         P=0.489          P=0.661N         P=0.125N         P=0.309N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 96
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        42/50 (84%)      34/49 (69%)      43/50 (86%)      37/49 (76%)      43/50 (86%)                      |
|POLY-3 ADJUSTED (b)|        87.4%            73.9%            88.7%            78.3%            89.9%                            |
|TERMINAL (d)       |        19/22 (86%)      17/23 (74%)      19/22 (86%)      19/25 (76%)      19/22 (86%)                      |
|FIRST INCIDENCE    |        485              597              312              249              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.304          P=0.064N         P=0.479N         P=0.079N         P=0.533                          |
|POLY 3             |        P=0.222          P=0.067N         P=0.551          P=0.169N         P=0.474                          |
|POLY 1.5           |        P=0.200          P=0.066N         P=0.527          P=0.183N         P=0.442                          |
|POLY 6             |        P=0.261          P=0.076N         P=0.583          P=0.170N         P=0.522                          |
|LOGISTIC REGRESSION|        P=0.191          P=0.037N*        P=0.523          P=0.199N         P=0.438                          |
|COCH-ARM / FISHERS |        P=0.241          P=0.069N         P=0.500          P=0.212N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 97
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        4/49 (8%)        4/50 (8%)        4/49 (8%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             9.2%             9.3%             9.3%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        2/23 (9%)        2/22 (9%)        1/25 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        729 (T)          663              663              681              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.181N         P=0.214          P=0.198          P=0.256          P=0.500N                         |
|POLY 3             |        P=0.190N         P=0.198          P=0.194          P=0.197          P=0.500N                         |
|POLY 1.5           |        P=0.192N         P=0.187          P=0.186          P=0.184          P=0.502N                         |
|POLY 6             |        P=0.188N         P=0.216          P=0.207          P=0.216          P=0.498N                         |
|LOGISTIC REGRESSION|        P=0.190N         P=0.201          P=0.210          P=0.199          (e)                              |
|COCH-ARM / FISHERS |        P=0.185N         P=0.175          P=0.181          P=0.175          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 98
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        33/50 (66%)      37/50 (74%)      36/50 (72%)      31/50 (62%)      34/50 (68%)                      |
|POLY-3 ADJUSTED (b)|        69.9%            75.0%            75.2%            66.6%            71.2%                            |
|TERMINAL (d)       |        15/22 (68%)      17/23 (74%)      16/22 (73%)      19/26 (73%)      15/22 (68%)                      |
|FIRST INCIDENCE    |        485              477              312              537              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.431N         P=0.501          P=0.484          P=0.173N         P=0.523                          |
|POLY 3             |        P=0.417N         P=0.366          P=0.359          P=0.450N         P=0.538                          |
|POLY 1.5           |        P=0.404N         P=0.317          P=0.345          P=0.445N         P=0.524                          |
|POLY 6             |        P=0.448N         P=0.438          P=0.387          P=0.460N         P=0.550                          |
|LOGISTIC REGRESSION|        P=0.375N         P=0.195          P=0.326          P=0.386N         P=0.510                          |
|COCH-ARM / FISHERS |        P=0.389N         P=0.257          P=0.333          P=0.418N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 99
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        0/48 (0%)        0/50 (0%)        1/47 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             6.8%             0.0%             0.0%             2.6%                             |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        729 (T)          615              ---              ---              603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.373N         P=0.359          P=0.500N         P=0.467N         P=0.752N                         |
|POLY 3             |        P=0.367N         P=0.337          P=0.499N         P=0.486N         P=0.750                          |
|POLY 1.5           |        P=0.375N         P=0.323          P=0.504N         P=0.493N         P=0.746                          |
|POLY 6             |        P=0.356N         P=0.357          P=0.491N         P=0.475N         P=0.757                          |
|LOGISTIC REGRESSION|        P=0.369N         P=0.297          (e)              (e)              P=0.750                          |
|COCH-ARM / FISHERS |        P=0.384N         P=0.309          P=0.510N         P=0.500N         P=0.737                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        1/48 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.1%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/39 (3%)                        |
|FIRST INCIDENCE    |        ---              513              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.431          P=0.500          (e)              (e)              P=0.605                          |
|POLY 3             |        P=0.426          P=0.518          (e)              (e)              P=0.517                          |
|POLY 1.5           |        P=0.413          P=0.510          (e)              (e)              P=0.505                          |
|POLY 6             |        P=0.446          P=0.533          (e)              (e)              P=0.535                          |
|LOGISTIC REGRESSION|        P=0.331          (e)              (e)              (e)              P=0.605                          |
|COCH-ARM / FISHERS |        P=0.396          P=0.500          (e)              (e)              P=0.490                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 100
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/49 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.6%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              643              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.521N         (e)              P=0.269          (e)              (e)                              |
|POLY 3             |        P=0.511N         (e)              P=0.250          (e)              (e)                              |
|POLY 1.5           |        P=0.516N         (e)              P=0.243          (e)              (e)                              |
|POLY 6             |        P=0.503N         (e)              P=0.260          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.507N         (e)              P=0.234          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.516N         (e)              P=0.247          (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 101
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        1/50 (2%)        2/49 (4%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             2.3%             4.6%             7.2%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        681              ---              723              628              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.066          P=0.481N         P=0.734N         P=0.568          P=0.327                          |
|POLY 3             |        P=0.064          P=0.487N         P=0.751N         P=0.523          P=0.309                          |
|POLY 1.5           |        P=0.064          P=0.493N         P=0.756N         P=0.508          P=0.304                          |
|POLY 6             |        P=0.064          P=0.480N         P=0.745N         P=0.544          P=0.318                          |
|LOGISTIC REGRESSION|        P=0.073          P=0.502N         P=0.749N         P=0.480          P=0.308                          |
|COCH-ARM / FISHERS |        P=0.068          P=0.500N         P=0.753N         P=0.492          P=0.309                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 102
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             4.9%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              537                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.021 *        (e)              (e)              (e)              P=0.235                          |
|POLY 3             |        P=0.021 *        (e)              (e)              (e)              P=0.239                          |
|POLY 1.5           |        P=0.021 *        (e)              (e)              (e)              P=0.236                          |
|POLY 6             |        P=0.021 *        (e)              (e)              (e)              P=0.244                          |
|LOGISTIC REGRESSION|        P=0.028 *        (e)              (e)              (e)              P=0.249                          |
|COCH-ARM / FISHERS |        P=0.023 *        (e)              (e)              (e)              P=0.247                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 103
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/50 (12%)       35/50 (70%)      37/50 (74%)      30/50 (60%)      31/50 (62%)                      |
|POLY-3 ADJUSTED (b)|        14.7%            74.6%            80.3%            64.7%            69.5%                            |
|TERMINAL (d)       |        5/22 (23%)       21/23 (91%)      21/22 (96%)      20/26 (77%)      18/22 (82%)                      |
|FIRST INCIDENCE    |        681              481              477              537              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.007 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 3             |        P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P=0.004 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.002 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P=0.004 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        46/50 (92%)      42/50 (84%)      44/50 (88%)      45/49 (92%)                      |
|POLY-3 ADJUSTED (b)|        2.3%             92.9%            87.9%            89.5%            94.5%                            |
|TERMINAL (d)       |        0/23 (0%)        38/40 (95%)      33/35 (94%)      35/37 (95%)      40/40 (100%)                     |
|FIRST INCIDENCE    |        571              513              85               550              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 104
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/50 (10%)       0/50 (0%)        3/50 (6%)        2/50 (4%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        12.0%            0.0%             7.0%             4.6%             4.9%                             |
|TERMINAL (d)       |        2/22 (9%)        0/23 (0%)        1/22 (5%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        565              ---              638              690              603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.332N         P=0.031N*        P=0.314N         P=0.153N         P=0.205N                         |
|POLY 3             |        P=0.356N         P=0.026N*        P=0.336N         P=0.194N         P=0.218N                         |
|POLY 1.5           |        P=0.352N         P=0.028N*        P=0.347N         P=0.205N         P=0.222N                         |
|POLY 6             |        P=0.359N         P=0.024N*        P=0.321N         P=0.179N         P=0.214N                         |
|LOGISTIC REGRESSION|        P=0.338N         P=0.034N*        P=0.353N         P=0.210N         P=0.215N                         |
|COCH-ARM / FISHERS |        P=0.340N         P=0.028N*        P=0.357N         P=0.218N         P=0.218N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        665              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.334N         P=0.470N         P=0.480N         P=0.465N         P=0.448N                         |
|POLY 3             |        P=0.379N         P=0.486N         P=0.492N         P=0.483N         P=0.483N                         |
|POLY 1.5           |        P=0.370N         P=0.493N         P=0.498N         P=0.491N         P=0.493N                         |
|POLY 6             |        P=0.397N         P=0.473N         P=0.482N         P=0.471N         P=0.465N                         |
|LOGISTIC REGRESSION|        P=0.375N         P=0.532N         P=0.494N         P=0.569N         P=0.553N                         |
|COCH-ARM / FISHERS |        P=0.361N         P=0.500N         P=0.500N         P=0.500N         P=0.505N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 105
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        37/50 (74%)      45/50 (90%)      44/50 (88%)      43/50 (86%)      39/50 (78%)                      |
|POLY-3 ADJUSTED (b)|        77.1%            93.0%            92.4%            87.7%            82.8%                            |
|TERMINAL (d)       |        16/22 (73%)      23/23 (100%)     22/22 (100%)     23/26 (89%)      19/22 (86%)                      |
|FIRST INCIDENCE    |        485              481              477              249              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.459N         P=0.308          P=0.278          P=0.538N         P=0.460                          |
|POLY 3             |        P=0.466N         P=0.019 *        P=0.025 *        P=0.122          P=0.320                          |
|POLY 1.5           |        P=0.464N         P=0.024 *        P=0.034 *        P=0.114          P=0.333                          |
|POLY 6             |        P=0.485N         P=0.014 *        P=0.017 *        P=0.139          P=0.294                          |
|LOGISTIC REGRESSION|        P=0.470N         P=0.043 *        P=0.071          P=0.098          P=0.388                          |
|COCH-ARM / FISHERS |        P=0.388N         P=0.033 *        P=0.062          P=0.105          P=0.408                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        39/50 (78%)      50/50 (100%)     47/50 (94%)      47/50 (94%)      46/49 (94%)                      |
|POLY-3 ADJUSTED (b)|        80.5%            100.0%           94.6%            94.7%            94.0%                            |
|TERMINAL (d)       |        19/23 (83%)      40/40 (100%)     34/35 (97%)      35/37 (95%)      38/40 (95%)                      |
|FIRST INCIDENCE    |        550              513              85               550              486                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.027N*        P=0.134N         P=0.247N         P=0.122N         P=0.023N*                        |
|POLY 3             |        P=0.148          P<0.001 **       P=0.026 *        P=0.026 *        P=0.037 *                        |
|POLY 1.5           |        P=0.117          P<0.001 **       P=0.023 *        P=0.022 *        P=0.029 *                        |
|POLY 6             |        P=0.218          P<0.001 **       P=0.034 *        P=0.036 *        P=0.059                          |
|LOGISTIC REGRESSION|        P=0.103          P<0.001 **       P=0.022 *        P=0.029 *        P=0.027 *                        |
|COCH-ARM / FISHERS |        P=0.096          P<0.001 **       P=0.020 *        P=0.020 *        P=0.022 *                        |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 106
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        499              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.156N         P=0.232N         P=0.235N         P=0.230N         P=0.244N                         |
|POLY 3             |        P=0.153N         P=0.228N         P=0.233N         P=0.227N         P=0.244N                         |
|POLY 1.5           |        P=0.153N         P=0.232N         P=0.236N         P=0.233N         P=0.243N                         |
|POLY 6             |        P=0.154N         P=0.222N         P=0.228N         P=0.220N         P=0.244N                         |
|LOGISTIC REGRESSION|        P=0.072N         P=0.291N         P=0.160N         P=0.170N         P=0.146N                         |
|COCH-ARM / FISHERS |        P=0.155N         P=0.247N         P=0.247N         P=0.247N         P=0.247N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 107
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Infiltration Cellular                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/50 (2%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             4.6%             0.0%             2.3%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        2/23 (9%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              729 (T)          ---              729 (T)          690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.513          P=0.247          (e)              P=0.533          P=0.521                          |
|POLY 3             |        P=0.505          P=0.253          (e)              P=0.514          P=0.500                          |
|POLY 1.5           |        P=0.502          P=0.246          (e)              P=0.507          P=0.498                          |
|POLY 6             |        P=0.510          P=0.262          (e)              P=0.525          P=0.504                          |
|LOGISTIC REGRESSION|        P=0.496          P=0.247          (e)              P=0.533          P=0.499                          |
|COCH-ARM / FISHERS |        P=0.505          P=0.247          (e)              P=0.500          P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Infiltration Cellular                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 108
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        12/50 (24%)      36/50 (72%)      38/50 (76%)      33/50 (66%)      28/50 (56%)                      |
|POLY-3 ADJUSTED (b)|        27.3%            73.8%            77.6%            69.6%            61.0%                            |
|TERMINAL (d)       |        4/22 (18%)       14/23 (61%)      17/22 (77%)      18/26 (69%)      12/22 (55%)                      |
|FIRST INCIDENCE    |        537              477              312              537              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.176          P<0.001 **       P<0.001 **       P=0.003 **       P=0.006 **                       |
|POLY 3             |        P=0.108          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P=0.105          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P=0.114          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P=0.128          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|COCH-ARM / FISHERS |        P=0.120          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        33/50 (66%)      45/50 (90%)      48/50 (96%)      48/50 (96%)      47/49 (96%)                      |
|POLY-3 ADJUSTED (b)|        71.8%            92.3%            97.0%            96.7%            98.6%                            |
|TERMINAL (d)       |        21/23 (91%)      39/40 (98%)      34/35 (97%)      36/37 (97%)      40/40 (100%)                     |
|FIRST INCIDENCE    |        550              513              85               550              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.264N         P=0.147N         P=0.454          P=0.496N         P=0.141N                         |
|POLY 3             |        P<0.001 **       P=0.004 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 1.5           |        P<0.001 **       P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|POLY 6             |        P<0.001 **       P=0.006 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.011 *        P<0.001 **       P<0.001 **       P=0.004 **                       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.004 **       P<0.001 **       P<0.001 **       P<0.001 **                       |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 109
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Capsule                                                                                                                  |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.5%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        729 (T)          ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.354N         P=0.491N         P=0.500N         P=0.467N         P=0.500N                         |
|POLY 3             |        P=0.361N         P=0.486N         P=0.491N         P=0.486N         P=0.500N                         |
|POLY 1.5           |        P=0.359N         P=0.492N         P=0.495N         P=0.493N         P=0.502N                         |
|POLY 6             |        P=0.363N         P=0.478N         P=0.483N         P=0.475N         P=0.498N                         |
|LOGISTIC REGRESSION|        P=0.354N         (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.359N         P=0.500N         P=0.500N         P=0.500N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Capsule                                                                                                                  |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.6%             0.0%             2.2%             2.1%             0.0%                             |
|TERMINAL (d)       |        1/23 (4%)        0/40 (0%)        1/35 (3%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        571              ---              730 (T)          730 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.194N         P=0.180N         P=0.408N         P=0.391N         P=0.182N                         |
|POLY 3             |        P=0.236N         P=0.223N         P=0.489N         P=0.473N         P=0.220N                         |
|POLY 1.5           |        P=0.239N         P=0.230N         P=0.498N         P=0.486N         P=0.230N                         |
|POLY 6             |        P=0.234N         P=0.210N         P=0.471N         P=0.452N         P=0.203N                         |
|LOGISTIC REGRESSION|        P=0.254N         P=0.277N         P=0.497N         P=0.584N         P=0.302N                         |
|COCH-ARM / FISHERS |        P=0.242N         P=0.247N         P=0.500N         P=0.500N         P=0.253N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 110
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        2/50 (4%)        2/50 (4%)        6/50 (12%)                       |
|POLY-3 ADJUSTED (b)|        2.5%             0.0%             4.6%             4.6%             14.1%                            |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        2/26 (8%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        729 (T)          ---              666              729 (T)          61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.003 **       P=0.491N         P=0.534          P=0.559          P=0.069                          |
|POLY 3             |        P=0.003 **       P=0.486N         P=0.520          P=0.525          P=0.063                          |
|POLY 1.5           |        P=0.003 **       P=0.492N         P=0.510          P=0.513          P=0.059                          |
|POLY 6             |        P=0.003 **       P=0.478N         P=0.536          P=0.543          P=0.069                          |
|LOGISTIC REGRESSION|        P=0.006 **       (e)              P=0.511          P=0.559          P=0.078                          |
|COCH-ARM / FISHERS |        P=0.003 **       P=0.500N         P=0.500          P=0.500          P=0.056                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        2/50 (4%)        3/50 (6%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             0.0%             4.4%             6.3%             0.0%                             |
|TERMINAL (d)       |        1/23 (4%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        730 (T)          ---              652              611              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.433N         P=0.390N         P=0.607          P=0.395          P=0.390N                         |
|POLY 3             |        P=0.473N         P=0.485N         P=0.518          P=0.345          P=0.481N                         |
|POLY 1.5           |        P=0.491N         P=0.492N         P=0.506          P=0.326          P=0.492N                         |
|POLY 6             |        P=0.445N         P=0.471N         P=0.540          P=0.376          P=0.463N                         |
|LOGISTIC REGRESSION|        P=0.552N         (e)              P=0.509          P=0.195          (e)                              |
|COCH-ARM / FISHERS |        P=0.512N         P=0.500N         P=0.500          P=0.309          P=0.505N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 111
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Red Pulp                                                                                                                 |
|     Depletion Cellular                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        2/50 (4%)        4/50 (8%)        2/50 (4%)                        |
|POLY-3 ADJUSTED (b)|        7.4%             6.9%             4.7%             9.1%             4.9%                             |
|TERMINAL (d)       |        2/22 (9%)        3/23 (13%)       2/22 (9%)        4/26 (15%)       1/22 (5%)                        |
|FIRST INCIDENCE    |        724              729 (T)          729 (T)          729 (T)          690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.449N         P=0.638N         P=0.500N         P=0.588          P=0.494N                         |
|POLY 3             |        P=0.473N         P=0.630N         P=0.479N         P=0.539          P=0.500N                         |
|POLY 1.5           |        P=0.472N         P=0.644N         P=0.490N         P=0.520          P=0.504N                         |
|POLY 6             |        P=0.473N         P=0.612N         P=0.463N         P=0.567          P=0.492N                         |
|LOGISTIC REGRESSION|        P=0.484N         P=0.614N         P=0.460N         P=0.608          P=0.497N                         |
|COCH-ARM / FISHERS |        P=0.458N         P=0.661N         P=0.500N         P=0.500          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Red Pulp                                                                                                                 |
|     Depletion Cellular                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)        2/50 (4%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             4.4%             4.3%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        1/35 (3%)        2/37 (5%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          652              730 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.419N         P=0.610          P=0.297          P=0.348          (e)                              |
|POLY 3             |        P=0.466N         P=0.515          P=0.249          P=0.258          (e)                              |
|POLY 1.5           |        P=0.488N         P=0.508          P=0.241          P=0.248          (e)                              |
|POLY 6             |        P=0.431N         P=0.529          P=0.263          P=0.274          (e)                              |
|LOGISTIC REGRESSION|        P=0.487N         P=0.610          P=0.237          P=0.348          (e)                              |
|COCH-ARM / FISHERS |        P=0.513N         P=0.500          P=0.247          P=0.247          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 112
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Edema                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        2/50 (4%)        2/50 (4%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             9.1%             4.7%             4.5%             7.3%                             |
|TERMINAL (d)       |        0/22 (0%)        1/23 (4%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        499              663              682              653              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.525          P=0.404          P=0.653N         P=0.640N         P=0.499                          |
|POLY 3             |        P=0.533          P=0.365          P=0.682N         P=0.673N         P=0.495                          |
|POLY 1.5           |        P=0.532          P=0.353          P=0.689N         P=0.684N         P=0.492                          |
|POLY 6             |        P=0.537          P=0.383          P=0.672N         P=0.656N         P=0.501                          |
|LOGISTIC REGRESSION|        P=0.540          P=0.307          P=0.687          P=0.682          P=0.506                          |
|COCH-ARM / FISHERS |        P=0.543          P=0.339          P=0.691N         P=0.691N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Edema                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.2%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              730 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.607N         (e)              P=0.584          (e)              (e)                              |
|POLY 3             |        P=0.643N         (e)              P=0.509          (e)              (e)                              |
|POLY 1.5           |        P=0.648N         (e)              P=0.503          (e)              (e)                              |
|POLY 6             |        P=0.636N         (e)              P=0.520          (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.584          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.652N         (e)              P=0.500          (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 113
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        11/50 (22%)      7/50 (14%)       4/50 (8%)        4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        9.5%             24.2%            15.9%            9.0%             9.7%                             |
|TERMINAL (d)       |        0/22 (0%)        3/23 (13%)       0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        499              597              638              637              684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.171N         P=0.093          P=0.353          P=0.548N         P=0.626N                         |
|POLY 3             |        P=0.158N         P=0.060          P=0.284          P=0.613N         P=0.632                          |
|POLY 1.5           |        P=0.160N         P=0.052          P=0.271          P=0.629N         P=0.631                          |
|POLY 6             |        P=0.155N         P=0.072          P=0.307          P=0.589N         P=0.635                          |
|LOGISTIC REGRESSION|        P=0.145N         P=0.031 *        P=0.247          P=0.619          P=0.635N                         |
|COCH-ARM / FISHERS |        P=0.152N         P=0.045 *        P=0.262          P=0.643N         P=0.643N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        1/50 (2%)        2/50 (4%)        2/50 (4%)        2/49 (4%)                        |
|POLY-3 ADJUSTED (b)|        9.1%             2.1%             4.4%             4.2%             4.2%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        550              694              652              550              689                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.318N         P=0.118N         P=0.252N         P=0.252N         P=0.198N                         |
|POLY 3             |        P=0.400N         P=0.161N         P=0.323N         P=0.300N         P=0.303N                         |
|POLY 1.5           |        P=0.409N         P=0.170N         P=0.335N         P=0.317N         P=0.324N                         |
|POLY 6             |        P=0.388N         P=0.146N         P=0.302N         P=0.274N         P=0.269N                         |
|LOGISTIC REGRESSION|        P=0.484N         P=0.226N         P=0.328N         P=0.569N         P=0.454N                         |
|COCH-ARM / FISHERS |        P=0.422N         P=0.181N         P=0.339N         P=0.339N         P=0.349N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 114
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/50 (8%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        9.5%             0.0%             4.6%             0.0%             2.4%                             |
|TERMINAL (d)       |        1/22 (5%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        499              ---              565              ---              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.179N         P=0.056N         P=0.315N         P=0.052N         P=0.188N                         |
|POLY 3             |        P=0.177N         P=0.055N         P=0.320N         P=0.055N         P=0.185N                         |
|POLY 1.5           |        P=0.176N         P=0.057N         P=0.329N         P=0.058N         P=0.186N                         |
|POLY 6             |        P=0.178N         P=0.052N         P=0.305N         P=0.050N         P=0.183N                         |
|LOGISTIC REGRESSION|        P=0.127N         P=0.086N         P=0.342N         P=0.065N         P=0.159N                         |
|COCH-ARM / FISHERS |        P=0.173N         P=0.059N         P=0.339N         P=0.059N         P=0.181N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        2/50 (4%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.3%             2.1%             4.4%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        550              694              571              635              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.244N         P=0.729N         P=0.502          P=0.750N         P=0.508N                         |
|POLY 3             |        P=0.249N         P=0.746N         P=0.517          P=0.742N         P=0.484N                         |
|POLY 1.5           |        P=0.259N         P=0.753N         P=0.506          P=0.751N         P=0.494N                         |
|POLY 6             |        P=0.233N         P=0.731N         P=0.539          P=0.727N         P=0.467N                         |
|LOGISTIC REGRESSION|        P=0.324N         P=0.726          P=0.580          P=0.577          P=0.426N                         |
|COCH-ARM / FISHERS |        P=0.270N         P=0.753N         P=0.500          P=0.753N         P=0.505N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 115
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        4/50 (8%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             4.5%             9.7%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              628              641                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.002 **       (e)              (e)              P=0.280          P=0.074                          |
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.256          P=0.062                          |
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.247          P=0.060                          |
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.271          P=0.065                          |
|LOGISTIC REGRESSION|        P=0.002 **       (e)              (e)              P=0.229          P=0.062                          |
|COCH-ARM / FISHERS |        P=0.002 **       (e)              (e)              P=0.247          P=0.059                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 116
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        8/50 (16%)       4/50 (8%)        0/50 (0%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        7.2%             17.9%            9.1%             0.0%             7.3%                             |
|TERMINAL (d)       |        0/22 (0%)        2/23 (9%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        499              642              561              ---              667                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.167N         P=0.160          P=0.551          P=0.105N         P=0.656N                         |
|POLY 3             |        P=0.145N         P=0.118          P=0.525          P=0.111N         P=0.654                          |
|POLY 1.5           |        P=0.149N         P=0.109          P=0.512          P=0.115N         P=0.653                          |
|POLY 6             |        P=0.140N         P=0.131          P=0.544          P=0.105N         P=0.658                          |
|LOGISTIC REGRESSION|        P=0.135N         P=0.080          P=0.487          P=0.110N         P=0.646N                         |
|COCH-ARM / FISHERS |        P=0.150N         P=0.100          P=0.500          P=0.121N         P=0.661N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/50 (12%)       0/50 (0%)        1/50 (2%)        3/50 (6%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        13.4%            0.0%             2.2%             6.2%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        1/35 (3%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        550              ---              730 (T)          550              718                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.125N         P=0.012N*        P=0.041N*        P=0.190N         P=0.030N*                        |
|POLY 3             |        P=0.150N         P=0.013N*        P=0.055N         P=0.205N         P=0.047N*                        |
|POLY 1.5           |        P=0.154N         P=0.014N*        P=0.057N         P=0.222N         P=0.053N                         |
|POLY 6             |        P=0.146N         P=0.011N*        P=0.049N*        P=0.181N         P=0.039N*                        |
|LOGISTIC REGRESSION|        P=0.218N         P=0.027N*        P=0.051N         P=0.627N         P=0.118N                         |
|COCH-ARM / FISHERS |        P=0.164N         P=0.013N*        P=0.056N         P=0.243N         P=0.059N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 117
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        1/50 (2%)        2/50 (4%)        1/50 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             9.0%             2.3%             4.5%             2.4%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        499              615              648              628              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.253N         P=0.382          P=0.490N         P=0.644N         P=0.510N                         |
|POLY 3             |        P=0.242N         P=0.371          P=0.487N         P=0.670N         P=0.500N                         |
|POLY 1.5           |        P=0.245N         P=0.356          P=0.494N         P=0.682N         P=0.503N                         |
|POLY 6             |        P=0.239N         P=0.394          P=0.475N         P=0.652N         P=0.496N                         |
|LOGISTIC REGRESSION|        P=0.182N         P=0.272          P=0.501N         P=0.683          P=0.394N                         |
|COCH-ARM / FISHERS |        P=0.243N         P=0.339          P=0.500N         P=0.691N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        1/50 (2%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.6%             2.2%             2.2%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        617              730 (T)          571              635              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.150N         P=0.429N         P=0.502N         P=0.474N         P=0.218N                         |
|POLY 3             |        P=0.162N         P=0.479N         P=0.486N         P=0.472N         P=0.220N                         |
|POLY 1.5           |        P=0.167N         P=0.489N         P=0.496N         P=0.485N         P=0.231N                         |
|POLY 6             |        P=0.156N         P=0.460N         P=0.468N         P=0.451N         P=0.204N                         |
|LOGISTIC REGRESSION|        P=0.201N         P=0.558N         P=0.442N         P=0.710N         P=0.300N                         |
|COCH-ARM / FISHERS |        P=0.171N         P=0.500N         P=0.500N         P=0.500N         P=0.253N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 118
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        7/50 (14%)       10/50 (20%)      10/50 (20%)                      |
|POLY-3 ADJUSTED (b)|        4.9%             9.1%             16.1%            22.0%            23.5%                            |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        1/22 (5%)                        |
|FIRST INCIDENCE    |        681              676              648              620              603                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.008 **       P=0.408          P=0.125          P=0.049 *        P=0.027 *                        |
|POLY 3             |        P=0.006 **       P=0.370          P=0.091          P=0.021 *        P=0.015 *                        |
|POLY 1.5           |        P=0.006 **       P=0.356          P=0.085          P=0.017 *        P=0.013 *                        |
|POLY 6             |        P=0.008 **       P=0.389          P=0.102          P=0.029 *        P=0.018 *                        |
|LOGISTIC REGRESSION|        P=0.006 **       P=0.367          P=0.090          P=0.015 *        P=0.015 *                        |
|COCH-ARM / FISHERS |        P=0.007 **       P=0.339          P=0.080          P=0.014 *        P=0.014 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.1%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        1/40 (3%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.173          (e)              (e)              (e)              P=0.610                          |
|POLY 3             |        P=0.151          (e)              (e)              (e)              P=0.519                          |
|POLY 1.5           |        P=0.147          (e)              (e)              (e)              P=0.508                          |
|POLY 6             |        P=0.157          (e)              (e)              (e)              P=0.537                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.610                          |
|COCH-ARM / FISHERS |        P=0.142          (e)              (e)              (e)              P=0.495                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 119
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        3/50 (6%)        1/50 (2%)        3/50 (6%)                        |
|POLY-3 ADJUSTED (b)|        7.3%             4.6%             6.9%             2.3%             7.2%                             |
|TERMINAL (d)       |        1/22 (5%)        1/23 (4%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        674              718              561              653              466                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.572          P=0.449N         P=0.606N         P=0.244N         P=0.649N                         |
|POLY 3             |        P=0.578          P=0.471N         P=0.635N         P=0.280N         P=0.655N                         |
|POLY 1.5           |        P=0.575          P=0.483N         P=0.649N         P=0.292N         P=0.662N                         |
|POLY 6             |        P=0.581N         P=0.455N         P=0.616N         P=0.263N         P=0.645N                         |
|LOGISTIC REGRESSION|        P=0.562N         P=0.443N         P=0.661          P=0.292N         P=0.655N                         |
|COCH-ARM / FISHERS |        P=0.581          P=0.500N         P=0.661N         P=0.309N         P=0.661N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.6%             2.1%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        571              645              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.096N         P=0.448N         P=0.211N         P=0.201N         P=0.193N                         |
|POLY 3             |        P=0.108N         P=0.475N         P=0.230N         P=0.221N         P=0.220N                         |
|POLY 1.5           |        P=0.107N         P=0.488N         P=0.236N         P=0.228N         P=0.230N                         |
|POLY 6             |        P=0.111N         P=0.454N         P=0.219N         P=0.208N         P=0.203N                         |
|LOGISTIC REGRESSION|        P=0.117N         P=0.572N         P=0.214N         P=0.349N         P=0.303N                         |
|COCH-ARM / FISHERS |        P=0.107N         P=0.500N         P=0.247N         P=0.247N         P=0.253N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 120
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/50 (12%)       10/50 (20%)      7/50 (14%)       6/50 (12%)       5/50 (10%)                       |
|POLY-3 ADJUSTED (b)|        14.2%            22.0%            15.5%            13.5%            12.1%                            |
|TERMINAL (d)       |        1/22 (5%)        3/23 (13%)       1/22 (5%)        3/26 (12%)       2/22 (9%)                        |
|FIRST INCIDENCE    |        537              481              477              620              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.235N         P=0.290          P=0.549          P=0.512N         P=0.499N                         |
|POLY 3             |        P=0.242N         P=0.255          P=0.552          P=0.586N         P=0.516N                         |
|POLY 1.5           |        P=0.238N         P=0.233          P=0.527          P=0.604N         P=0.515N                         |
|POLY 6             |        P=0.248N         P=0.283          P=0.587          P=0.561N         P=0.516N                         |
|LOGISTIC REGRESSION|        P=0.197N         P=0.163          P=0.468          P=0.619          P=0.503N                         |
|COCH-ARM / FISHERS |        P=0.217N         P=0.207          P=0.500          P=0.620N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 121
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        27/50 (54%)      27/50 (54%)      26/50 (52%)      24/50 (48%)      26/50 (52%)                      |
|POLY-3 ADJUSTED (b)|        57.5%            57.2%            54.8%            49.5%            55.5%                            |
|TERMINAL (d)       |        10/22 (46%)      12/23 (52%)      11/22 (50%)      11/26 (42%)      8/22 (36%)                       |
|FIRST INCIDENCE    |        485              597              312              249              466                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.440N         P=0.418N         P=0.418N         P=0.186N         P=0.486N                         |
|POLY 3             |        P=0.408N         P=0.571N         P=0.477N         P=0.280N         P=0.507N                         |
|POLY 1.5           |        P=0.430N         P=0.579N         P=0.487N         P=0.308N         P=0.526N                         |
|POLY 6             |        P=0.373N         P=0.548N         P=0.464N         P=0.241N         P=0.471N                         |
|LOGISTIC REGRESSION|        P=0.363N         P=0.505          P=0.580N         P=0.523N         P=0.484N                         |
|COCH-ARM / FISHERS |        P=0.411N         P=0.579N         P=0.500N         P=0.345N         P=0.500N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 122
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        40/46 (87%)      43/44 (98%)      44/45 (98%)      46/46 (100%)     41/41 (100%)                     |
|POLY-3 ADJUSTED (b)|        88.7%            97.9%            99.8%            100.0%           100.0%                           |
|TERMINAL (d)       |        18/20 (90%)      20/20 (100%)     22/22 (100%)     24/24 (100%)     17/17 (100%)                     |
|FIRST INCIDENCE    |        485              477              477              249              61                               |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.312          P=0.541          P=0.553          P=0.489N         P=0.369                          |
|POLY 3             |        P=0.008 **       P=0.079          P=0.025 *        P=0.020 *        P=0.028 *                        |
|POLY 1.5           |        P=0.006 **       P=0.071          P=0.028 *        P=0.017 *        P=0.024 *                        |
|POLY 6             |        P=0.012 *        P=0.097          P=0.031 *        P=0.027 *        P=0.037 *                        |
|LOGISTIC REGRESSION|        P=0.006 **       P=0.057          P=0.065          P=0.016 *        P=0.024 *                        |
|COCH-ARM / FISHERS |        P=0.008 **       P=0.062          P=0.059          P=0.013 *        P=0.019 *                        |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        44/46 (96%)      48/48 (100%)     47/48 (98%)      49/49 (100%)     46/46 (100%)                     |
|POLY-3 ADJUSTED (b)|        96.3%            100.0%           100.0%           100.0%           100.0%                           |
|TERMINAL (d)       |        21/21 (100%)     40/40 (100%)     33/33 (100%)     36/36 (100%)     39/39 (100%)                     |
|FIRST INCIDENCE    |        550              513              506              550              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.004N**       P=0.002N**       P=0.040N*        P=0.016N*        P<0.001N**                       |
|POLY 3             |        P=0.175          P=0.267          P=0.272          P=0.262          P=0.277                          |
|POLY 1.5           |        P=0.160          P=0.246          P=0.261          P=0.242          P=0.256                          |
|POLY 6             |        P=0.206          P=0.314          P=0.319          P=0.309          P=0.324                          |
|LOGISTIC REGRESSION|        P=0.194          P=0.237          P=0.292          P=0.238          P=0.272                          |
|COCH-ARM / FISHERS |        P=0.153          P=0.237          P=0.484          P=0.232          P=0.247                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 123
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        14/50 (28%)      22/50 (44%)      14/48 (29%)      13/50 (26%)      12/47 (26%)                      |
|POLY-3 ADJUSTED (b)|        33.7%            48.8%            34.0%            29.2%            30.6%                            |
|TERMINAL (d)       |        9/22 (41%)       13/23 (57%)      11/22 (50%)      10/26 (39%)      8/22 (36%)                       |
|FIRST INCIDENCE    |        620              481              704              537              646                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.105N         P=0.135          P=0.549N         P=0.300N         P=0.394N                         |
|POLY 3             |        P=0.139N         P=0.108          P=0.581          P=0.411N         P=0.475N                         |
|POLY 1.5           |        P=0.152N         P=0.090          P=0.558          P=0.455N         P=0.492N                         |
|POLY 6             |        P=0.119N         P=0.134          P=0.578N         P=0.354N         P=0.445N                         |
|LOGISTIC REGRESSION|        P=0.138N         P=0.146          P=0.467N         P=0.332N         P=0.438N                         |
|COCH-ARM / FISHERS |        P=0.148N         P=0.072          P=0.538          P=0.500N         P=0.483N                         |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        21/50 (42%)      29/50 (58%)      20/50 (40%)      18/50 (36%)      18/49 (37%)                      |
|POLY-3 ADJUSTED (b)|        48.0%            61.5%            43.9%            38.0%            37.6%                            |
|TERMINAL (d)       |        17/23 (74%)      26/40 (65%)      17/35 (49%)      16/37 (43%)      16/40 (40%)                      |
|FIRST INCIDENCE    |        575              589              652              638              718                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.002N**       P=0.208N         P=0.044N*        P=0.009N**       P=0.004N**                       |
|POLY 3             |        P=0.032N*        P=0.130          P=0.428N         P=0.222N         P=0.210N                         |
|POLY 1.5           |        P=0.052N         P=0.101          P=0.481N         P=0.276N         P=0.281N                         |
|POLY 6             |        P=0.014N*        P=0.207          P=0.327N         P=0.145N         P=0.118N                         |
|LOGISTIC REGRESSION|        P=0.006N**       P=0.351          P=0.218N         P=0.064N         P=0.024N*                        |
|COCH-ARM / FISHERS |        P=0.093N         P=0.081          P=0.500N         P=0.341N         P=0.371N                         |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 124
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        3/48 (6%)        5/50 (10%)       4/47 (9%)                        |
|POLY-3 ADJUSTED (b)|        7.3%             4.6%             7.3%             11.3%            10.0%                            |
|TERMINAL (d)       |        1/22 (5%)        2/23 (9%)        2/22 (9%)        3/26 (12%)       1/22 (5%)                        |
|FIRST INCIDENCE    |        648              729 (T)          719              663              421                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.263          P=0.455N         P=0.629N         P=0.465          P=0.494                          |
|POLY 3             |        P=0.244          P=0.472N         P=0.663          P=0.396          P=0.486                          |
|POLY 1.5           |        P=0.238          P=0.484N         P=0.652          P=0.376          P=0.473                          |
|POLY 6             |        P=0.251          P=0.458N         P=0.651N         P=0.424          P=0.503                          |
|LOGISTIC REGRESSION|        P=0.241          P=0.449N         P=0.639N         P=0.405          P=0.509                          |
|COCH-ARM / FISHERS |        P=0.240          P=0.500N         P=0.641          P=0.357          P=0.465                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              722              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.686          (e)              (e)              P=0.610          (e)                              |
|POLY 3             |        P=0.678          (e)              (e)              P=0.518          (e)                              |
|POLY 1.5           |        P=0.661          (e)              (e)              P=0.510          (e)                              |
|POLY 6             |        P=0.702          (e)              (e)              P=0.531          (e)                              |
|LOGISTIC REGRESSION|        P=0.665          (e)              (e)              P=0.552          (e)                              |
|COCH-ARM / FISHERS |        P=0.639          (e)              (e)              P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 125
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        1/48 (2%)        1/50 (2%)        3/47 (6%)                        |
|POLY-3 ADJUSTED (b)|        7.3%             6.8%             2.4%             2.3%             7.8%                             |
|TERMINAL (d)       |        2/22 (9%)        2/23 (9%)        1/22 (5%)        0/26 (0%)        2/22 (9%)                        |
|FIRST INCIDENCE    |        665              642              729 (T)          690              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.576N         P=0.626N         P=0.300N         P=0.241N         P=0.650N                         |
|POLY 3             |        P=0.562          P=0.629N         P=0.304N         P=0.280N         P=0.635                          |
|POLY 1.5           |        P=0.560          P=0.644N         P=0.312N         P=0.293N         P=0.629                          |
|POLY 6             |        P=0.565          P=0.611N         P=0.292N         P=0.263N         P=0.644                          |
|LOGISTIC REGRESSION|        P=0.562          P=0.620N         P=0.280N         P=0.271N         P=0.652                          |
|COCH-ARM / FISHERS |        P=0.567          P=0.661N         P=0.324N         P=0.309N         P=0.631                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.1%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        1/37 (3%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              730 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.679          (e)              (e)              P=0.595          (e)                              |
|POLY 3             |        P=0.678          (e)              (e)              P=0.518          (e)                              |
|POLY 1.5           |        P=0.661          (e)              (e)              P=0.509          (e)                              |
|POLY 6             |        P=0.702          (e)              (e)              P=0.531          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.595          (e)                              |
|COCH-ARM / FISHERS |        P=0.639          (e)              (e)              P=0.500          (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 126
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        1/49 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.6%             0.0%             2.5%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        0/26 (0%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              643              ---              699                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.391          (e)              P=0.269          (e)              P=0.492                          |
|POLY 3             |        P=0.397          (e)              P=0.250          (e)              P=0.496                          |
|POLY 1.5           |        P=0.395          (e)              P=0.243          (e)              P=0.494                          |
|POLY 6             |        P=0.400          (e)              P=0.260          (e)              P=0.499                          |
|LOGISTIC REGRESSION|        P=0.405          (e)              P=0.234          (e)              P=0.496                          |
|COCH-ARM / FISHERS |        P=0.402          (e)              P=0.247          (e)              P=0.495                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/49 (0%)        0/49 (0%)        0/49 (0%)        0/50 (0%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|TERMINAL (d)       |        0/23 (0%)        0/40 (0%)        0/35 (0%)        0/37 (0%)        0/40 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 127
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        8/50 (16%)       8/50 (16%)       11/50 (22%)      8/50 (16%)       9/49 (18%)                       |
|POLY-3 ADJUSTED (b)|        18.7%            17.9%            25.1%            17.8%            22.6%                            |
|TERMINAL (d)       |        4/22 (18%)       4/23 (17%)       4/22 (18%)       4/26 (15%)       8/22 (36%)                       |
|FIRST INCIDENCE    |        485              597              643              593              690                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.489          P=0.542N         P=0.359          P=0.490N         P=0.498                          |
|POLY 3             |        P=0.409          P=0.569N         P=0.323          P=0.568N         P=0.435                          |
|POLY 1.5           |        P=0.427          P=0.586N         P=0.311          P=0.589N         P=0.446                          |
|POLY 6             |        P=0.388          P=0.544N         P=0.349          P=0.534N         P=0.421                          |
|LOGISTIC REGRESSION|        P=0.456          P=0.547          P=0.302          P=0.581          P=0.475                          |
|COCH-ARM / FISHERS |        P=0.474          P=0.607N         P=0.306          P=0.607N         P=0.482                          |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        13/49 (27%)      16/49 (33%)      9/49 (18%)       25/50 (50%)      17/49 (35%)                      |
|POLY-3 ADJUSTED (b)|        30.1%            35.0%            20.2%            51.7%            35.4%                            |
|TERMINAL (d)       |        8/23 (35%)       16/40 (40%)      7/35 (20%)       18/37 (49%)      14/40 (35%)                      |
|FIRST INCIDENCE    |        575              730 (T)          652              634              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.418          P=0.243N         P=0.057N         P=0.257          P=0.322N                         |
|POLY 3             |        P=0.175          P=0.392          P=0.205N         P=0.026 *        P=0.377                          |
|POLY 1.5           |        P=0.134          P=0.360          P=0.227N         P=0.018 *        P=0.317                          |
|POLY 6             |        P=0.252          P=0.454          P=0.168N         P=0.045 *        P=0.481                          |
|LOGISTIC REGRESSION|        P=0.176          P=0.561          P=0.185N         P=0.033 *        P=0.336                          |
|COCH-ARM / FISHERS |        P=0.096          P=0.329          P=0.234N         P=0.014 *        P=0.256                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 128
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        1/50 (2%)        1/50 (2%)        0/49 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             2.3%             2.3%             0.0%                             |
|TERMINAL (d)       |        0/22 (0%)        0/23 (0%)        0/22 (0%)        1/26 (4%)        0/22 (0%)                        |
|FIRST INCIDENCE    |        ---              718              603              729 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.506N         P=0.531          P=0.519          P=0.533          (e)                              |
|POLY 3             |        P=0.508N         P=0.514          P=0.511          P=0.514          (e)                              |
|POLY 1.5           |        P=0.511N         P=0.508          P=0.506          P=0.507          (e)                              |
|POLY 6             |        P=0.504N         P=0.522          P=0.520          P=0.525          (e)                              |
|LOGISTIC REGRESSION|        P=0.510N         P=0.528          P=0.511          P=0.533          (e)                              |
|COCH-ARM / FISHERS |        P=0.508N         P=0.500          P=0.500          P=0.500          (e)                              |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/49 (0%)        1/49 (2%)        1/49 (2%)        4/50 (8%)        4/49 (8%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.2%             2.3%             8.5%             8.4%                             |
|TERMINAL (d)       |        0/23 (0%)        1/40 (3%)        0/35 (0%)        3/37 (8%)        2/40 (5%)                        |
|FIRST INCIDENCE    |        ---              730 (T)          703              675              712                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.038 *        P=0.610          P=0.557          P=0.129          P=0.153                          |
|POLY 3             |        P=0.021 *        P=0.516          P=0.510          P=0.076          P=0.077                          |
|POLY 1.5           |        P=0.018 *        P=0.508          P=0.503          P=0.070          P=0.069                          |
|POLY 6             |        P=0.027 *        P=0.530          P=0.522          P=0.088          P=0.093                          |
|LOGISTIC REGRESSION|        P=0.022 *        P=0.610          P=0.505          P=0.084          P=0.098                          |
|COCH-ARM / FISHERS |        P=0.015 *        P=0.500          P=0.500          P=0.061          P=0.059                          |
|=================================================================================================================================|
       Date:  02/25/99                           EXPERIMENT: 88036 TEST: 03                                            Page 129
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   ANTHRAQUINONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                                                                             |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            469 PPM          938 PPM          1875 PPM         3750 PPM                         |
|                   |                                                                                                             |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        3/50 (6%)        3/50 (6%)        4/49 (8%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             6.5%             6.7%             6.4%             8.5%                             |
|TERMINAL (d)       |        0/23 (0%)        3/40 (8%)        2/35 (6%)        3/37 (8%)        4/40 (10%)                       |
|FIRST INCIDENCE    |        ---              730 (T)          723              730 (T)          730 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.208          P=0.234          P=0.210          P=0.216          P=0.153                          |
|POLY 3             |        P=0.140          P=0.133          P=0.127          P=0.135          P=0.073                          |
|POLY 1.5           |        P=0.124          P=0.126          P=0.121          P=0.128          P=0.066                          |
|POLY 6             |        P=0.169          P=0.147          P=0.138          P=0.149          P=0.088                          |
|LOGISTIC REGRESSION|        P=0.212          P=0.234          P=0.179          P=0.216          P=0.153                          |
|COCH-ARM / FISHERS |        P=0.106          P=0.121          P=0.121          P=0.121          P=0.056                          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).