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TDMS Study 88045-03 Pathology Tables

NTP Experiment-Test: 88045-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98
Route: GAVAGE                                                                                                     Time: 09:43:20

                                                       13 WEEK SUBCHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  110-69-0

       Lock Date:  11/13/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88045-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:43:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       9           
    Moribund Sacrifice                                                                                                  1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10                        

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hepatodiaphragmatic Nodule                       3 (30%)      1 (10%)      2 (20%)      2 (20%)      1 (10%)      1 (10%)     
      Inflammation, Chronic Active                     8 (80%)      8 (80%)      6 (60%)      5 (50%)      4 (40%)                  
      Necrosis                                                                                                         10 (100%)    
   Stomach, Glandular                                 (10)                                                (10)         (10)         
      Congestion                                                                                                        1 (10%)     
      Erosion                                                                                                           1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (10)         (10)         
      Inflammation, Chronic Active                     3 (30%)                                             4 (40%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                   (1)          (10)         (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
   Thyroid Gland                                      (10)                                                (10)         (10)         
      Infiltration Cellular, Lymphocyte                                                                    1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:43:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                                             3 (30%)     10 (100%)                 
   Lymph Node, Mandibular                             (10)                                                (10)         (10)         
      Atrophy                                                                                                           8 (80%)     
      Hyperplasia, Histiocytic                         2 (20%)                                             2 (20%)                  
      Hyperplasia, Plasma Cell                                                                             1 (10%)                  
   Lymph Node, Mesenteric                             (10)         (4)          (1)          (5)          (10)         (10)         
      Atrophy                                                                                                           7 (70%)     
      Hyperplasia, Histiocytic                         4 (40%)      4 (100%)     1 (100%)     5 (100%)     4 (40%)                  
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                 7 (70%)      9 (90%)      8 (80%)     10 (100%)    10 (100%)     9 (90%)     
      Pigmentation                                    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)                 
      Lymphatic, Depletion Cellular                                                                                     9 (90%)     
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                 1 (10%)      1 (10%)                  
      Hemorrhage                                       1 (10%)                                                                      
      Necrosis                                                                                                         10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                (10)         (10)         
      Inflammation, Chronic Active                                                                         1 (10%)                  
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                                  2 (20%)                   1 (10%)                               
      Olfactory Epithelium, Degeneration                            4 (40%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:43:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Mineralization                                   7 (70%)                                             7 (70%)                  
      Nephropathy                                      1 (10%)                                                                      
   Urinary Bladder                                    (10)                                                (10)         (10)         
      Infiltration Cellular, Lymphocyte                                                                    2 (20%)                  
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:43:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       9           
    Moribund Sacrifice                                                                                                  1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10                        

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (10)                                                (10)         (10)         
      Parasite Metazoan                                1 (10%)                                             1 (10%)                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)      3 (30%)                   2 (20%)                   1 (10%)     
      Inflammation, Chronic Active                     2 (20%)      2 (20%)      1 (10%)      3 (30%)                   1 (10%)     
      Necrosis                                                                                             1 (10%)     10 (100%)    
      Centrilobular, Vacuolization Cytoplasmic         7 (70%)      1 (10%)                                                         
   Stomach, Forestomach                               (10)                                                (10)         (10)         
      Hemorrhage                                                                                                        1 (10%)     
   Stomach, Glandular                                 (10)                                                (10)         (10)         
      Erosion                                                                                                           2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (10)         (10)         
      Hemorrhage                                       1 (10%)                                                                      
      Inflammation, Chronic Active                    10 (100%)                                            9 (90%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)                                                (10)         (10)         
      Cyst                                                                                                 1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:43:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)                                                (10)         (10)         
      Hypospermia                                                                                                      10 (100%)    
   Seminal Vesicle                                    (10)                                                (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
   Testes                                             (10)                      (1)          (1)          (10)         (10)         
      Degeneration, Focal                                                        1 (100%)     1 (100%)                              
      Hypoplasia                                                                                                        9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                                                         10 (100%)                 
   Lymph Node, Mandibular                             (10)                      (1)          (2)          (10)         (10)         
      Atrophy                                                                                                           7 (70%)     
      Hyperplasia, Plasma Cell                         2 (20%)                   1 (100%)     2 (100%)     6 (60%)                  
   Lymph Node, Mesenteric                             (10)         (1)          (2)          (3)          (10)         (10)         
      Atrophy                                                                                                           5 (50%)     
      Hyperplasia, Histiocytic                         1 (10%)      1 (100%)     2 (100%)     3 (100%)     1 (10%)                  
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                 9 (90%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Pigmentation                                    10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)                 
      Capsule, Inflammation, Chronic Active                                                                1 (10%)                  
      Lymphatic, Depletion Cellular                                                                                    10 (100%)    
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                              1 (10%)                  
      Hemorrhage                                                                                                        2 (20%)     
      Necrosis                                                                                             2 (20%)     10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:43:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                (10)         (10)         
      Hemorrhage                                       2 (20%)                                                          2 (20%)     
      Inflammation, Chronic Active                     2 (20%)                                                          1 (10%)     
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Olfactory Epithelium, Degeneration                            1 (10%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Respiratory Epithelium, Degeneration                                       1 (10%)      2 (20%)      6 (60%)      8 (80%)     
      Respiratory Epithelium, Metaplasia, Squamous                                                         9 (90%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Accumulation, Hyaline Droplet                    2 (20%)                                                                      
      Inflammation, Chronic Active, Focal              1 (10%)                                                                      
      Nephropathy                                      6 (60%)                                             1 (10%)      1 (10%)     
   Urinary Bladder                                    (10)                                                (10)         (10)         
      Infiltration Cellular, Diffuse, Lymphocyte       1 (10%)                                                                      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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                             ----------              END OF REPORT             ----------                                           
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