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TDMS Study 88045-04 Pathology Tables

NTP Experiment-Test: 88045-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98
Route: GAVAGE                                                                                                     Time: 09:45:53

                                                       13 WEEK SUBCHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  110-69-0

       Lock Date:  11/13/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88045-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:45:53  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       9           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            1           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                     3 (30%)      3 (30%)      1 (10%)                   1 (10%)      1 (10%)     
      Necrosis                                                                                                          9 (90%)     
      Pigmentation                                                                                                      2 (20%)     
      Tension Lipidosis                                             1 (10%)                                                         
      Vacuolization Cytoplasmic                                                                            4 (40%)      5 (50%)     
   Salivary Glands                                    (10)                                                (10)         (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (2)          (1)          (3)          (10)         (10)         
      Accessory Adrenal Cortical Nodule                             1 (50%)      1 (100%)     1 (33%)      1 (10%)                  
      Vacuolization Cytoplasmic                        3 (30%)                                                                      
      Bilateral, Vacuolization Cytoplasmic             2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:45:53  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                (9)          (9)          
      Atrophy                                                                                                           1 (11%)     
   Lymph Node, Mesenteric                             (10)                                                (10)         (8)          
      Atrophy                                                                                                           1 (13%)     
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Hematopoietic Cell Proliferation                 1 (10%)      1 (10%)                   1 (10%)     10 (100%)     2 (22%)     
      Pigmentation                                                                            1 (10%)     10 (100%)     8 (89%)     
      Lymphatic, Atrophy                                                                                                7 (78%)     
   Thymus                                             (9)                                                 (10)         (10)         
      Atrophy                                                                                                           8 (80%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (9)          
      Exudate, Suppurative                                                                    2 (20%)      1 (10%)      5 (56%)     
      Olfactory Epithelium, Degeneration                                         8 (80%)     10 (100%)    10 (100%)     9 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Hydronephrosis                                   1 (10%)                                                                      
   Urinary Bladder                                    (10)                                                (9)          (8)          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:45:53  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Edema                                            1 (10%)                                                                      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:45:53  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       5           
    Moribund Sacrifice                                                                                                  1           
    Dosing Accident                                                                                                     1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            3           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                                                                                    2 (20%)     
      Necrosis                                                                                                          7 (70%)     
      Necrosis, Focal                                                                         1 (10%)                               
      Pigmentation                                                                                                      3 (30%)     
      Vacuolization Cytoplasmic                                                                            3 (30%)      5 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (1)                       (2)          (10)         (10)         
      Accessory Adrenal Cortical Nodule                                                                    1 (10%)                  
      Subcapsular, Hyperplasia                         1 (10%)                                             2 (20%)      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)                                                (10)         (10)         
      Cyst                                                                                                 2 (20%)                  
   Testes                                             (10)                                                (10)         (10)         
      Mineralization                                                                                                    2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:45:53  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)                                                (10)         (10)         
      Hyperplasia                                                                                          1 (10%)      5 (50%)     
   Lymph Node, Mesenteric                             (9)                                                 (10)         (9)          
      Atrophy                                                                                                           2 (22%)     
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                                        2 (20%)     10 (100%)     7 (70%)     
      Pigmentation                                                                                        10 (100%)     9 (90%)     
      Lymphatic, Atrophy                                                                                                7 (70%)     
   Thymus                                             (9)                                                 (10)         (8)          
      Atrophy                                                                                                           4 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (10)                                                (10)         (10)         
      Cranium, Fibrous Osteodystrophy                                                                                   1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Exudate, Suppurative                                                                                 2 (20%)     10 (100%)    
      Olfactory Epithelium, Degeneration                                         2 (20%)     10 (100%)    10 (100%)    10 (100%)    
      Respiratory Epithelium, Degeneration                                                                              1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88045-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   BUTANAL OXIME                                       Date: 09/30/98  
Route: GAVAGE                                                                                                     Time: 09:45:53  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      25 MG/KG     50 MG/KG     100          200          600             
                                                                                          MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Urinary Bladder                                    (10)                                                (10)         (8)          
      Edema                                                                                                2 (20%)      1 (13%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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                             ----------              END OF REPORT             ----------                                           
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