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TDMS Study 88050-05 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                                METHACRYLONITRILE                                           DATE: 02/24/00    
EXPERIMENT: 88050 TEST: 05                                                                                        TIME: 14:30:48    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: GAVAGE                                                 NTP:  C88050B     
CONT: NO1-ES-55388                                                                                                CAS: 126-98-7     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE COLUMBUS LABORATORY                     METHACRYLONITRILE                                           DATE: 02/24/00


EXPERIMENT: 88050 TEST: 05                                                                                        TIME: 14:37:10


SPECIES: RATS, FISCHER 344                             


TEST TYPE: TWO YEAR                                 ROUTE: ORAL GAVAGE                                            NTP:  88050B


CONT: NO1-ES-55388                                                                                                CAS: 126-98-7

                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
                              TWO YEAR ORAL GAVAGE STUDY OF METHACRYLONITRILE

==========================================================================================================
WEEK     0 MG/KG                3 MG/KG                  10 MG/KG                 30 MG/KG
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B       105.3       50       106.9    101.5    50     105.5    100.2    50     106.6    101.2    50
  1       105.3       50       106.9    101.5    50     105.5    100.2    50     106.6    101.2    50
  5       232.6       50       236.0    101.5    50     232.5    100.0    50     230.9     99.3    50
  8       287.3       49       290.8    101.2    50     285.5     99.4    50     274.1     95.4    50
 13       339.4       49       341.5    100.6    50     338.7     99.8    50     325.8     96.0    50
 17       376.6       49       376.2     99.9    50     371.0     98.5    50     358.7     95.2    50
 21       398.5       49       398.4    100.0    50     392.6     98.5    50     379.2     95.2    50
 25       413.3       49       416.8    100.8    50     410.2     99.2    50     388.4     94.0    50
 29       428.5       49       424.4     99.0    50     420.1     98.0    50     401.4     93.7    50
 33       439.7       49       438.5     99.7    50     432.6     98.4    50     413.8     94.1    50
 37       449.7       49       449.7    100.0    50     445.7     99.1    50     424.7     94.4    50
 41       456.0       49       456.2    100.0    50     448.4     98.3    49     422.7     92.7    50
 44       465.7       49       464.2     99.7    50     458.2     98.4    49     434.8     93.4    50
 49       466.4       49       466.0     99.9    50     460.9     98.8    49     437.1     93.7    50
 53       471.6       49       471.1     99.9    50     463.1     98.2    49     440.5     93.4    49
 57       472.0       49       469.7     99.5    50     465.2     98.6    49     437.5     92.7    49
 61       475.5       49       471.1     99.1    49     467.7     98.4    49     440.3     92.6    49
 65       471.9       48       477.6    101.2    49     456.0     96.6    49     441.5     93.6    49
 69       482.3       46       474.0     98.3    48     466.8     96.8    46     446.8     92.6    47
 73       485.2       45       482.7     99.5    48     467.5     96.4    45     444.3     91.6    47
 77       463.7       45       475.7    102.6    48     466.6    100.6    45     444.5     95.9    44
 81       478.4       44       470.2     98.3    47     467.2     97.7    45     439.2     91.8    44
 85       485.5       41       478.7     98.6    47     471.4     97.1    45     445.4     91.7    44
 89       485.8       39       490.4    100.9    45     471.6     97.1    44     444.4     91.5    43
 93       488.4       37       487.5     99.8    44     468.3     95.9    43     444.0     90.9    41
 97       466.4       35       473.0    101.4    43     451.4     96.8    42     443.2     95.0    38
101       462.9       30       472.3    102.0    36     456.1     98.5    38     432.8     93.5    35

TERM. SAC.            25                         34                       35                       31


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
                              TWO YEAR ORAL GAVAGE STUDY OF METHACRYLONITRILE

==========================================================================================================
WEEK     0 MG/KG                3 MG/KG                  10 MG/KG                 30 MG/KG
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        91.8       50        92.1    100.3    50      92.8    101.1    50      92.5    100.8    50
  1        91.8       50        92.1    100.3    50      92.8    101.1    50      92.5    100.8    50
  5       149.9       50       147.7     98.5    50     148.1     98.8    50     147.5     98.4    50
  8       171.6       50       169.4     98.7    50     169.2     98.6    50     168.1     98.0    50
 13       190.7       50       186.0     97.5    50     188.1     98.6    50     184.4     96.7    50
 17       200.4       50       197.3     98.5    50     199.0     99.3    50     193.3     96.5    50
 21       207.3       50       206.1     99.4    50     206.0     99.4    50     200.7     96.8    50
 25       210.3       50       207.2     98.5    50     209.2     99.5    50     201.0     95.6    50
 29       218.4       50       216.8     99.3    50     217.8     99.7    50     208.9     95.7    50
 33       221.3       50       221.0     99.9    50     220.2     99.5    50     211.6     95.6    50
 37       228.7       50       226.7     99.1    50     228.3     99.8    50     219.5     96.0    49
 41       236.5       50       235.2     99.5    50     235.1     99.4    49     221.2     93.5    49
 44       241.5       50       238.7     98.8    50     239.4     99.1    49     227.4     94.2    49
 49       252.1       50       249.9     99.1    49     251.5     99.8    48     238.9     94.8    49
 53       254.7       50       252.0     98.9    49     251.0     98.5    48     234.4     92.0    49
 57       261.3       50       258.8     99.0    49     258.0     98.7    48     244.4     93.5    49
 61       271.4       50       265.0     97.6    49     267.9     98.7    48     253.9     93.6    49
 65       279.6       49       274.1     98.0    48     273.8     97.9    47     258.7     92.5    49
 69       282.7       49       278.8     98.6    48     281.7     99.6    45     266.3     94.2    49
 73       289.7       49       285.4     98.5    48     287.8     99.3    45     268.0     92.5    47
 77       295.7       48       290.5     98.2    46     291.1     98.4    44     273.2     92.4    46
 81       301.6       48       291.1     96.5    45     295.0     97.8    44     278.2     92.2    44
 85       308.1       48       306.0     99.3    44     307.2     99.7    43     284.4     92.3    44
 89       315.4       46       312.5     99.1    42     311.2     98.7    42     289.0     91.6    42
 93       310.1       45       319.0    102.9    41     308.4     99.5    42     291.1     93.9    41
 97       309.7       45       314.3    101.5    41     309.8    100.0    40     292.4     94.4    41
101       309.7       42       319.0    103.0    36     301.3     97.3    37     290.0     93.6    38

TERM. SAC.            38                         33                       34                       37


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.