Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/5118

TDMS Study 88050-06 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                                METHACRYLONITRILE                                           DATE: 10/19/99    
EXPERIMENT: 88050 TEST: 06                                                                                        TIME: 12:34:23    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: GAVAGE                                                 NTP:  C88050B     
CONT: NO1-ES-55388                                                                                                CAS: 126-98-7     
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE COLUMBUS LABORATORY                     METHACRYLONITRILE                                           DATE: 10/19/99


EXPERIMENT: 88050 TEST: 06                                                                                        TIME: 12:44:05



TEST TYPE: TWO YEAR                                 ROUTE: ORAL GAVAGE                                            NTP:  88050B

CONT: NO1-ES-55388                                                                                                CAS: 126-98-7

                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
                              TWO YEAR ORAL GAVAGE STUDY OF METHACRYLONITRILE

==========================================================================================================
WEEK     0 MG/KG                1.5     MG/KG            3 MG/KG                  6 MG/KG
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        21.8       50        22.0    100.9    50      21.7     99.5    50      21.9    100.5    50
  1        21.8       50        22.0    100.9    50      21.7     99.5    50      21.9    100.5    50
  5        27.8       50        27.4     98.6    50      26.6     95.7    50      26.8     96.4    49
  9        32.3       50        32.9    101.9    50      31.4     97.2    50      30.6     94.7    49
 13        36.3       49        36.4    100.3    50      34.8     95.9    50      34.3     94.5    49
 17        39.3       49        39.4    100.3    50      38.3     97.5    50      36.6     93.1    49
 21        44.5       49        43.9     98.7    50      43.0     96.6    50      40.5     91.0    49
 25        46.5       49        45.9     98.7    50      44.9     96.6    50      42.4     91.2    49
 29        47.7       49        47.1     98.7    50      46.6     97.7    50      44.1     92.5    49
 33        48.9       49        48.0     98.2    50      47.7     97.5    50      45.2     92.4    49
 37        49.2       49        48.7     99.0    50      48.5     98.6    50      46.8     95.1    49
 41        49.4       49        48.8     98.8    50      49.0     99.2    50      46.9     94.9    49
 45        50.3       49        49.2     97.8    50      49.7     98.8    50      47.6     94.6    49
 49        50.1       49        49.7     99.2    50      50.0     99.8    50      48.2     96.2    49
 53        50.6       49        50.2     99.2    50      50.7    100.2    50      48.8     96.4    49
 57        50.6       49        50.4     99.6    50      51.1    101.0    50      49.1     97.0    49
 61        50.2       49        50.4    100.4    50      51.4    102.4    50      49.5     98.6    49
 65        49.9       49        50.3    100.8    50      51.4    103.0    48      49.5     99.2    49
 69        50.0       49        50.5    101.0    50      51.3    102.6    48      49.6     99.2    49
 73        48.6       48        49.5    101.9    50      50.2    103.3    47      48.3     99.4    25
 77        47.7       47        48.8    102.3    50      50.1    105.0    47      47.9    100.4    25
 81        47.5       47        48.2    101.5    50      49.9    105.1    47      48.0    101.1    25
 85        47.4       46        48.8    103.0    49      50.2    105.9    47      48.1    101.5    25
 89        45.6       45        47.5    104.2    48      48.9    107.2    46      47.3    103.7    25
 93        43.4       44        46.3    106.7    44      47.2    108.8    46      46.7    107.6    23
 97        44.7       41        47.4    106.0    44      48.0    107.4    45      47.0    105.1    23
101        42.5       37        45.4    106.8    44      45.6    107.3    44      44.6    104.9    23

TERM. SAC.            35                         43                       43                       22


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
                              TWO YEAR ORAL GAVAGE STUDY OF METHACRYLONITRILE

==========================================================================================================
WEEK     0 MG/KG                1.5     MG/KG            3 MG/KG                  6 MG/KG
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        18.4       50        18.5    100.5    50      18.6    101.1    50      18.3     99.5    50
  1        18.4       50        18.5    100.5    50      18.6    101.1    50      18.3     99.5    50
  5        22.7       50        22.9    100.9    50      22.9    100.9    50      22.2     97.8    50
  9        26.2       50        26.2    100.0    50      27.0    103.1    50      25.5     97.3    50
 13        30.0       50        30.2    100.7    50      32.2    107.3    50      29.0     96.7    50
 17        34.0       50        35.0    102.9    50      36.2    106.5    50      34.3    100.9    50
 21        38.9       50        39.5    101.5    50      41.6    106.9    50      38.9    100.0    50
 25        42.1       50        42.9    101.9    50      44.8    106.4    50      42.3    100.5    50
 29        44.8       50        45.7    102.0    50      48.0    107.1    50      44.6     99.6    50
 32        47.6       50        48.4    101.7    50      50.2    105.5    50      46.1     96.8    49
 37        50.6       50        51.4    101.6    50      53.0    104.7    50      49.6     98.0    49
 41        52.6       50        52.8    100.4    50      54.3    103.2    50      51.3     97.5    49
 45        54.2       50        54.4    100.4    49      55.3    102.0    50      53.0     97.8    48
 49        56.0       50        56.6    101.1    49      57.2    102.1    50      54.6     97.5    48
 53        57.7       49        57.5     99.7    49      57.9    100.3    50      56.3     97.6    47
 57        58.0       49        58.3    100.5    48      57.9     99.8    50      56.7     97.8    47
 61        57.9       49        57.7     99.7    47      58.8    101.6    50      56.8     98.1    47
 65        57.3       49        57.8    100.9    46      57.9    101.0    50      56.1     97.9    47
 69        58.1       49        58.8    101.2    45      58.8    101.2    50      57.2     98.5    47
 73        57.4       48        58.6    102.1    45      58.0    101.0    50      56.2     97.9    32
 77        57.2       48        58.9    103.0    44      57.9    101.2    49      55.6     97.2    32
 81        57.6       48        59.1    102.6    43      57.0     99.0    49      55.8     96.9    32
 85        56.9       48        59.1    103.9    42      55.8     98.1    49      55.6     97.7    31
 89        55.7       46        58.3    104.7    42      56.5    101.4    46      54.0     96.9    31
 93        55.5       43        56.8    102.3    40      55.5    100.0    46      53.6     96.6    29
 97        57.4       39        56.7     98.8    39      56.4     98.3    45      53.4     93.0    29
101        53.2       38        53.6    100.8    39      53.8    101.1    45      51.4     96.6    27

TERM. SAC.            35                         35                       43                       25


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.