TDMS Study 88050-06 Pathology Tables
NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 FINAL#1, CORE STUDY MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 126-98-7 Lock Date: 06/26/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 14 13 4 7 Moribund Sacrifice 1 2 3 3 Accidently Killed 15 Survivors Natural Death 1 Terminal Sacrifice 34 35 43 25 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Periesophageal Tissue, Inflammation, Chronic Active 1 (2%) Gallbladder (50) (50) (50) (48) Cyst 1 (2%) Infiltration Cellular, Mononuclear Cell 1 (2%) Intestine Small, Duodenum (49) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Metaplasia, Squamous 1 (2%) Epithelium, Ulcer 1 (2%) Intestine Small, Jejunum (50) (50) (50) (50) Ulcer 1 (2%) Epithelium, Inflammation, Suppurative 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 2 (4%) Liver (50) (50) (49) (50) Angiectasis 1 (2%) 1 (2%) Basophilic Focus 1 (2%) 7 (14%) 2 (4%) 2 (4%) Clear Cell Focus 3 (6%) 6 (12%) 6 (12%) 1 (2%) Eosinophilic Focus 9 (18%) 3 (6%) 11 (22%) 3 (6%) Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 6 (12%) 2 (4%) Hepatodiaphragmatic Nodule 1 (2%) Infiltration Cellular, Mononuclear Cell 30 (60%) 36 (72%) 40 (82%) 30 (60%) Inflammation, Chronic Active 32 (64%) 36 (72%) 41 (84%) 38 (76%) Mineralization 1 (2%) 1 (2%) Mixed Cell Focus 3 (6%) 1 (2%) 3 (6%) Necrosis 3 (6%) 2 (4%) 2 (4%) 1 (2%) Pigmentation 18 (36%) 12 (24%) 17 (35%) 7 (14%) Tension Lipidosis 2 (4%) 3 (6%) Hepatocyte, Vacuolization Cytoplasmic 7 (14%) 9 (18%) 3 (6%) 18 (36%) Mesentery (16) (11) (15) (4) Fibrosis 8 (50%) 7 (64%) 10 (67%) 2 (50%) Hemorrhage 1 (9%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Inflammation, Chronic Active 5 (31%) 6 (55%) 8 (53%) Mineralization 5 (31%) 7 (64%) 12 (80%) 1 (25%) Pigmentation 1 (7%) Thrombosis 1 (7%) Fat, Necrosis 8 (50%) 7 (64%) 11 (73%) 3 (75%) Oral Mucosa (3) (5) (2) (1) Gingival, Foreign Body 2 (67%) 5 (100%) 1 (50%) Gingival, Inflammation, Chronic Active 2 (67%) 5 (100%) 2 (100%) Pharyngeal, Foreign Body 1 (33%) Pancreas (50) (50) (50) (48) Cyst 1 (2%) Infiltration Cellular, Mononuclear Cell 2 (4%) Acinus, Atrophy 1 (2%) Acinus, Hyperplasia 1 (2%) Salivary Glands (48) (50) (50) (49) Infiltration Cellular, Mononuclear Cell 27 (56%) 29 (58%) 32 (64%) 27 (55%) Inflammation, Chronic Active 2 (4%) 1 (2%) Mineralization 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Diverticulum 1 (2%) Hyperkeratosis 1 (2%) Epithelium, Hyperplasia 3 (6%) 2 (4%) 1 (2%) 1 (2%) Epithelium, Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) 1 (2%) Epithelium, Ulcer 1 (2%) 1 (2%) 1 (2%) Stomach, Glandular (50) (50) (50) (50) Ectopic Tissue 1 (2%) Mineralization 1 (2%) 1 (2%) 1 (2%) Epithelium, Dysplasia 1 (2%) Epithelium, Erosion 1 (2%) Glands, Ectasia 16 (32%) 9 (18%) 10 (20%) 3 (6%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (49) (50) (50) (50) Aorta, Mineralization 1 (2%) Heart (50) (50) (50) (50) Inflammation, Suppurative 1 (2%) Mineralization 1 (2%) Artery, Mineralization 1 (2%) Valve, Inflammation, Chronic Active 1 (2%) Valve, Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (50) (50) Accessory Adrenal Cortical Nodule 2 (4%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hypertrophy 1 (2%) 1 (2%) Infiltration Cellular, Mononuclear Cell 1 (2%) Capsule, Hyperplasia 48 (98%) 48 (96%) 50 (100%) 50 (100%) Zona Reticularis, Hyperplasia 1 (2%) Adrenal Medulla (49) (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) Islets, Pancreatic (50) (50) (50) (49) Hyperplasia 41 (82%) 37 (74%) 40 (80%) 33 (67%) Pituitary Gland (49) (49) (49) (49) Pars Distalis, Angiectasis 2 (4%) 3 (6%) 6 (12%) 2 (4%) Pars Distalis, Cyst 1 (2%) 2 (4%) 2 (4%) Pars Distalis, Hemorrhage 1 (2%) Pars Distalis, Hyperplasia 9 (18%) 12 (24%) 10 (20%) 11 (22%) Pars Distalis, Pigmentation 1 (2%) Thyroid Gland (49) (50) (50) (50) Ectopic Thymus 1 (2%) Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) C-Cell, Hyperplasia 1 (2%) Follicle, Cyst 5 (10%) 3 (6%) 3 (6%) 4 (8%) Follicular Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (50) (50) (49) Infiltration Cellular, Mononuclear Cell 4 (8%) 2 (4%) 3 (6%) 1 (2%) Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%) Pigmentation 1 (2%) Duct, Cyst 2 (4%) 2 (4%) Ovary (50) (50) (50) (49) Angiectasis 1 (2%) Cyst 17 (34%) 14 (28%) 18 (36%) 10 (20%) Hemorrhage 1 (2%) 4 (8%) 1 (2%) Inflammation, Suppurative 1 (2%) Mineralization 2 (4%) 3 (6%) 2 (4%) 1 (2%) Pigmentation 7 (14%) 16 (32%) 11 (22%) 6 (12%) Thrombosis 1 (2%) 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Uterus (50) (50) (50) (50) Angiectasis 1 (2%) Hemorrhage 1 (2%) Hydrometra 23 (46%) 28 (56%) 31 (62%) 20 (40%) Inflammation, Chronic Active 1 (2%) Inflammation, Suppurative 1 (2%) Pigmentation 1 (2%) Thrombosis 1 (2%) Endometrium, Hyperplasia 1 (2%) Endometrium, Hyperplasia, Cystic 27 (54%) 24 (48%) 24 (48%) 32 (64%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hyperplasia 2 (4%) 2 (4%) 4 (8%) 1 (2%) Myelofibrosis 2 (4%) 3 (6%) Lymph Node (9) (6) (8) (5) Lumbar, Ectasia 1 (17%) 1 (20%) Lumbar, Hyperplasia, Lymphoid 1 (13%) Mediastinal, Hyperplasia, Lymphoid 1 (11%) 2 (25%) Mediastinal, Infiltration Cellular, Histiocyte 1 (11%) Mediastinal, Inflammation 1 (20%) Pancreatic, Fibrosis 1 (11%) Pancreatic, Hyperplasia, Lymphoid 1 (11%) Pancreatic, Pigmentation 1 (11%) Lymph Node, Mandibular (48) (49) (46) (47) Hyperplasia, Lymphoid 5 (10%) 4 (8%) 3 (7%) 1 (2%) Infiltration Cellular, Plasma Cell 1 (2%) Pigmentation 3 (6%) 16 (33%) 9 (20%) 4 (9%) Lymph Node, Mesenteric (47) (48) (47) (46) Ectasia 2 (4%) Hemorrhage 2 (4%) 1 (2%) Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) Pigmentation 1 (2%) Spleen (50) (50) (49) (49) Hematopoietic Cell Proliferation 18 (36%) 22 (44%) 15 (31%) 10 (20%) Hyperplasia, Lymphoid 1 (2%) 3 (6%) 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) Pigmentation 1 (2%) Thymus (47) (43) (46) (48) Cyst 20 (43%) 17 (40%) 23 (50%) 19 (40%) Ectopic Parathyroid Gland 1 (2%) 1 (2%) 1 (2%) Hyperplasia, Lymphoid 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Thymocyte, Necrosis 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (49) (50) (49) (49) Hyperplasia, Cystic 3 (6%) 1 (2%) Skin (50) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Epidermis, Ulcer 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteosclerosis 1 (2%) Skeletal Muscle (4) (1) (2) Infiltration Cellular, Mononuclear Cell 1 (25%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Hemorrhage 1 (2%) Infiltration Cellular, Mononuclear Cell 2 (4%) Inflammation, Chronic Active 1 (2%) Meninges, Hemorrhage 1 (2%) Peripheral Nerve (1) (1) Sciatic, Axon, Degeneration 1 (100%) Spinal Cord (1) (2) Demyelination 1 (100%) 1 (50%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Hemorrhage 1 (2%) Inflammation, Chronic Active 2 (4%) 1 (2%) 3 (6%) 1 (2%) Mineralization 5 (10%) 1 (2%) 2 (4%) 2 (4%) Necrosis 1 (2%) Pigmentation 1 (2%) Thrombosis 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%) Artery, Mediastinum, Mineralization 1 (2%) Mediastinum, Mineralization 1 (2%) Nose (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) (1) (4) Atrophy 1 (50%) 1 (100%) 1 (25%) Anterior Chamber, Infiltration Cellular, Polymorphonuclear 1 (25%) Cornea, Inflammation, Chronic Active 1 (25%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) Accumulation, Hyaline Droplet 2 (4%) 1 (2%) Hydronephrosis 1 (2%) Infarct, Multiple 1 (2%) Infiltration Cellular, Mononuclear Cell 35 (70%) 42 (84%) 44 (90%) 35 (70%) Inflammation, Chronic Active 1 (2%) 1 (2%) Mineralization 5 (10%) 5 (10%) 5 (10%) 6 (12%) Nephropathy 15 (30%) 19 (38%) 22 (45%) 9 (18%) Pigmentation 1 (2%) Capsule, Mineralization 1 (2%) Cortex, Cyst 2 (4%) 3 (6%) 1 (2%) 1 (2%) Papilla, Inflammation, Acute 1 (2%) Renal Tubule, Casts Protein 1 (2%) Urinary Bladder (50) (50) (50) (50) Infiltration Cellular, Mononuclear Cell 28 (56%) 31 (62%) 29 (58%) 22 (44%) Inflammation, Chronic Active 1 (2%) Pigmentation 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 9 5 4 3 Moribund Sacrifice 5 2 3 Dosing Accident 1 Accidently Killed 24 Survivors Terminal Sacrifice 34 43 41 22 Natural Death 1 2 Missing 1 Animals Examined Microscopically 49 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (49) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Periesophageal Tissue, Inflammation, Chronic Active 1 (2%) Intestine Small, Duodenum (49) (49) (50) (50) Ectasia 1 (2%) Hyperplasia 3 (6%) 1 (2%) 1 (2%) Intestine Small, Jejunum (49) (50) (50) (50) Inflammation, Chronic Active 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%) Intestine Small, Ileum (49) (50) (50) (49) Inflammation, Chronic Active 1 (2%) 1 (2%) Liver (49) (50) (50) (50) Angiectasis 1 (2%) 1 (2%) Basophilic Focus 4 (8%) 6 (12%) 2 (4%) Clear Cell Focus 7 (14%) 10 (20%) 10 (20%) 4 (8%) Eosinophilic Focus 16 (33%) 10 (20%) 12 (24%) 3 (6%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 3 (6%) 1 (2%) Hepatodiaphragmatic Nodule 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Infiltration Cellular, Mononuclear Cell 9 (18%) 11 (22%) 7 (14%) 6 (12%) Inflammation, Chronic Active 22 (45%) 21 (42%) 19 (38%) 21 (42%) Inflammation, Granulomatous 1 (2%) Malformation 1 (2%) Mineralization 1 (2%) Mixed Cell Focus 11 (22%) 11 (22%) 2 (4%) Necrosis 6 (12%) 5 (10%) 1 (2%) Pigmentation 3 (6%) 2 (4%) 3 (6%) Tension Lipidosis 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Bile Duct, Cyst 1 (2%) 1 (2%) Bile Duct, Hyperplasia 1 (2%) Hepatocyte, Vacuolization Cytoplasmic 6 (12%) 10 (20%) 9 (18%) 16 (32%) Hepatocyte, Portal, Hypertrophy 1 (2%) Hepatocyte, Centrilobular, Degeneration 1 (2%) Mesentery (3) (6) (6) (1) Fibrosis 1 (33%) 1 (17%) Inflammation, Chronic Active 1 (33%) 1 (17%) 1 (17%) 1 (100%) Inflammation, Granulomatous 2 (33%) Mineralization 1 (17%) 1 (17%) Thrombosis 1 (33%) Fat, Necrosis 1 (33%) 2 (33%) 1 (17%) Oral Mucosa (31) (30) (27) (10) Gingival, Foreign Body 27 (87%) 29 (97%) 26 (96%) 10 (100%) Gingival, Inflammation, Acute 9 (29%) 3 (10%) 10 (37%) 6 (60%) Gingival, Inflammation, Chronic 1 (3%) Gingival, Inflammation, Chronic Active 19 (61%) 26 (87%) 16 (59%) 2 (20%) Pancreas (49) (50) (50) (50) Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%) 1 (2%) Artery, Mineralization 1 (2%) Salivary Glands (49) (50) (50) (50) Granuloma 1 (2%) Infiltration Cellular, Mononuclear Cell 22 (45%) 35 (70%) 36 (72%) 29 (58%) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 1 (2%) Mineralization 1 (2%) 1 (2%) 1 (2%) Stomach, Forestomach (49) (50) (50) (50) Cyst, Squamous 1 (2%) Epithelium, Hyperplasia 2 (4%) 3 (6%) 1 (2%) 1 (2%) Epithelium, Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%) Epithelium, Ulcer 1 (2%) 1 (2%) Stomach, Glandular (49) (50) (50) (50) Hyperplasia 1 (2%) Mineralization 1 (2%) 2 (4%) Ulcer 1 (2%) Epithelium, Erosion 1 (2%) Epithelium, Hyperplasia 1 (2%) 1 (2%) Epithelium, Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Glands, Ectasia 17 (35%) 10 (20%) 20 (40%) 5 (10%) Serosa, Inflammation, Granulomatous 1 (2%) Tooth (6) (1) (2) Malformation 6 (100%) 1 (100%) 2 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (48) (50) (50) (50) Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%) Mineralization 2 (4%) 1 (2%) 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (49) (50) (50) (50) Degeneration, Fatty 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 14 (29%) 12 (24%) 16 (32%) 7 (14%) Hypertrophy 26 (53%) 34 (68%) 28 (56%) 15 (30%) Inflammation, Suppurative 1 (2%) Metaplasia, Osseous 1 (2%) Capsule, Hyperplasia 41 (84%) 41 (82%) 40 (80%) 45 (90%) Adrenal Medulla (49) (50) (50) (50) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 1 (2%) Islets, Pancreatic (49) (50) (50) (50) Hyperplasia 47 (96%) 43 (86%) 48 (96%) 46 (92%) Parathyroid Gland (42) (35) (39) (38) Cyst 1 (2%) 2 (6%) 1 (3%) 1 (3%) Pituitary Gland (48) (49) (49) (46) Atypia Cellular 1 (2%) Pars Distalis, Cyst 1 (2%) 2 (4%) 5 (10%) 3 (7%) Pars Distalis, Hyperplasia 2 (4%) 2 (4%) Thyroid Gland (49) (50) (50) (50) Follicle, Cyst 2 (4%) 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Coagulating Gland (1) (2) Inflammation, Suppurative 1 (100%) Epididymis (49) (50) (50) (50) Atrophy 1 (2%) Granuloma Sperm 2 (4%) 1 (2%) Infiltration Cellular, Mononuclear Cell 17 (35%) 26 (52%) 30 (60%) 21 (42%) Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Mineralization 2 (4%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Penis (1) Hemorrhage 1 (100%) Preputial Gland (49) (50) (50) (49) Atrophy 1 (2%) Infiltration Cellular, Mononuclear Cell 21 (43%) 25 (50%) 27 (54%) 26 (53%) Inflammation, Chronic Active 13 (27%) 6 (12%) 7 (14%) 3 (6%) Duct, Cyst 18 (37%) 20 (40%) 18 (36%) 16 (33%) Prostate (49) (50) (50) (50) Atrophy 1 (2%) Infiltration Cellular, Mononuclear Cell 25 (51%) 31 (62%) 34 (68%) 32 (64%) Inflammation, Suppurative 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) Seminal Vesicle (49) (50) (50) (50) Atrophy 1 (2%) Dilatation 1 (2%) Infiltration Cellular, Mononuclear Cell 2 (4%) 2 (4%) Testes (49) (50) (50) (50) Atrophy 1 (2%) Inflammation, Chronic Active 1 (2%) Mineralization 2 (4%) 2 (4%) 1 (2%) Germinal Epithelium, Atrophy 1 (2%) 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (50) (50) (50) Hyperplasia 4 (8%) Lymph Node (3) (5) (3) (1) Inguinal, Hyperplasia, Plasma Cell 1 (20%) Lumbar, Hyperplasia, Plasma Cell 1 (20%) Mediastinal, Hyperplasia, Plasma Cell 1 (20%) Pancreatic, Hyperplasia, Lymphoid 1 (20%) Renal, Hyperplasia, Plasma Cell 1 (20%) Renal, Inflammation, Suppurative 1 (20%) Lymph Node, Mandibular (46) (48) (50) (47) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Hyperplasia, Plasma Cell 1 (2%) 1 (2%) Infiltration Cellular, Polymorphonuclear 1 (2%) Lymph Node, Mesenteric (46) (43) (49) (47) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%) Hyperplasia, Plasma Cell 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) Inflammation, Granulomatous 1 (2%) Inflammation, Suppurative 1 (2%) Spleen (49) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hematopoietic Cell Proliferation 12 (24%) 13 (26%) 14 (28%) 4 (8%) Hyperplasia, Lymphoid 1 (2%) 4 (8%) 1 (2%) Thymus (40) (48) (46) (49) Atypia Cellular 1 (2%) Cyst 16 (40%) 19 (40%) 18 (39%) 17 (35%) Ectopic Parathyroid Gland 3 (8%) 1 (2%) 3 (7%) 1 (2%) Ectopic Thyroid 1 (3%) Mineralization 1 (2%) Thymocyte, Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (49) (50) (50) (50) Infiltration Cellular, Mononuclear Cell 1 (2%) Inflammation, Chronic Active 2 (4%) 3 (6%) Epidermis, Hyperkeratosis 1 (2%) Epidermis, Hyperplasia 2 (4%) 2 (4%) Epidermis, Ulcer 2 (4%) 2 (4%) Epidermis, Pinna, Hyperplasia 1 (2%) Epidermis, Pinna, Ulcer 1 (2%) Pinna, Inflammation, Chronic Active 1 (2%) Subcutaneous Tissue, Fibrosis 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) (50) Hemorrhage 1 (2%) 1 (2%) Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 2 (4%) 2 (4%) 4 (8%) Mineralization 3 (6%) 1 (2%) 2 (4%) Thrombosis 3 (6%) 2 (4%) 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 6 (12%) 5 (10%) 4 (8%) Alveolus, Infiltration Cellular, Histiocyte 4 (8%) 8 (16%) 3 (6%) 3 (6%) Bronchiole, Foreign Body 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88050-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC METHACRYLONITRILE Date: 10/25/99 Route: GAVAGE Time: 08:32:57 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 1.5 3 MG/KG 6 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Mediastinum, Inflammation, Chronic Active 1 (2%) Mediastinum, Inflammation, Suppurative 1 (2%) Pleura, Inflammation, Chronic Active 1 (2%) Nose (49) (50) (50) (50) Foreign Body 3 (6%) 3 (6%) 4 (8%) 1 (2%) Inflammation, Chronic Active 2 (4%) 3 (6%) Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (1) (1) Cornea, Inflammation, Chronic Active 1 (100%) Cornea, Inflammation, Suppurative 1 (100%) Cornea, Metaplasia, Squamous 1 (100%) Harderian Gland (3) (2) (7) (1) Infiltration Cellular, Mononuclear Cell 1 (33%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (50) (50) (50) Infarct 2 (4%) 2 (4%) 1 (2%) Infiltration Cellular, Mononuclear Cell 27 (55%) 37 (74%) 39 (78%) 22 (44%) Inflammation, Chronic Active 1 (2%) 1 (2%) Inflammation, Suppurative 1 (2%) Metaplasia, Osseous 2 (4%) 1 (2%) Mineralization 43 (88%) 49 (98%) 47 (94%) 36 (72%) Nephropathy 43 (88%) 48 (96%) 47 (94%) 39 (78%) Artery, Inflammation, Chronic Active 1 (2%) Cortex, Cyst 11 (22%) 12 (24%) 8 (16%) 9 (18%) Renal Tubule, Hyperplasia 9 (18%) 8 (16%) 9 (18%) 2 (4%) Renal Tubule, Necrosis 1 (2%) Urinary Bladder (49) (50) (50) (50) Hemorrhage 1 (2%) Infiltration Cellular, Mononuclear Cell 12 (24%) 17 (34%) 9 (18%) 10 (20%) Inflammation, Suppurative 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------