TDMS Study 88066-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: A. D. Little POLYVINYL ALCOHOL DATE: 08/14/96 EXPERIMENT: 88066 TEST: 01 TIME: 19:56:22 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-15330 ROUTE: VAGINAL NTP C#: 88066 PATHOLOGIST: GOAD, MARY CAS: 9002-89-5 ------------------------------------------------------------------------------------------------------------------------------------ UNTREATED CONTROL VS 25% REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE 001 UNTREATDCONTROL INCLUDE 003 25% NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: A. D. Little POLYVINYL ALCOHOL DATE: 08/14/96 EXPERIMENT: 88066 TEST: 01 TIME: 19:56:22 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-15330 ROUTE: VAGINAL NTP C#: 88066 PATHOLOGIST: GOAD, MARY CAS: 9002-89-5 POLYVINYL ALCOHOL STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = UNTREATDCONTROL | | ---------------------------- | | | | TOTAL 100 UNCENSORED DEATHS 43 CENSORED DEATHS 10 TERMINAL 47 | | | | UNCENSORED DEATHS | | 175 357 365 400 410 473 476 529 538 539 | | 581 592 595 606 625 634 640 643 646 652 | | 655 655 657 657 659 666 668 668 675 682 | | 682 686 690 696 703 704 709 711 714 718 | | 721 725 725 | | CENSORED DEATHS | | 67 110 168 350 441 483 511 530 595 704 | | | |--------------------------------------------------------------------------------| | DOSE = 25% | | --------------------- | | | | TOTAL 100 UNCENSORED DEATHS 34 CENSORED DEATHS 5 TERMINAL 61 | | | | UNCENSORED DEATHS | | 72 324 372 514 542 553 619 620 620 624 | | 624 627 634 638 640 646 646 651 658 661 | | 668 675 682 686 688 690 696 697 701 704 | | 708 714 721 721 | | CENSORED DEATHS | | 112 313 504 507 637 | | | ================================================================================== POLYVINYL ALCOHOL STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 729 (A) | | | |--------------------------------------------------------------------------------| | | | |UNTREATDCON|ROL100.0 99.0 99.0 96.9 94.8 92.7 89.4 86.2 72.9 52.9 | |U | | | | | |25% | 99.0 99.0 99.0 98.0 97.0 97.0 94.9 93.8 79.1 64.4 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | UNTREATDCONTROL 25% | | U | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 52.9% 64.4% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.142N P=0.142N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 611.7 618.7 | |NATURAL DEATHS (C) | (18.4) (22.4) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 645.2 675.8 | |(STANDARD ERROR) | (14.3) (11.7) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) POLYVINYL ALCOHOL KAPLAN-MEIER SURVIVAL CURVES UNTREATDCONTROL = 1 25% = 2 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 | 2 1 2 1 | 2 1 12 1 2 | 11 2 2 95 + 1 1 22 | 2 2 | 1 1 | 11 22 90 + 1 1 | 1 1 | 22 | 1 1 22 P 85 + 1 1 22 E | 11 R | 11 C | 112 E 80 + 11 2 N | 22 T | 222 | S 75 + 22 U | 1 1 R | 11 22 V | 22 I 70 + 11 V | 11 22 A | L | 22 65 + 11 | 11 2 2 | 11 | 11 60 + | | 11 | 55 + 11 | | 1 1 | 50 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 6 obs hidden.