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https://ntp.niehs.nih.gov/go/5136

TDMS Study 88066-01 Pathology Tables

NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96
Route: VAGINAL                                                                                                    Time: 18:27:59

                                                           CORE STUDY




       Facility:  Arthur D. Little Life Science Laboratories

       Chemical CAS #:  9002-89-5

       Lock Date:  07/28/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                         100          100          100                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     24           20           21                                                  
    Accidently Killed                                 10            4            5                                                  
    Moribund Sacrifice                                19           25           13                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           51           61                                                  
  Animals Examined Microscopically                   100          100          100                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (100)        (100)        (99)                                                
      Periesophageal Tissue, Inflammation, Chronic                               1 (1%)                                             
   Gallbladder                                        (76)         (87)         (79)                                                
      Hyperplasia                                      1 (1%)                                                                       
   Intestine Large, Colon                             (92)         (93)         (97)                                                
      Inflammation, Chronic                                         1 (1%)       1 (1%)                                             
      Lymphoid Tissue, Hyperplasia                     1 (1%)                                                                       
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Intestine Large, Rectum                            (89)         (91)         (96)                                                
      Inflammation, Chronic                                         1 (1%)       1 (1%)                                             
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Intestine Large, Cecum                             (88)         (92)         (96)                                                
      Inflammation, Chronic                                         1 (1%)                                                          
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Intestine Small, Duodenum                          (88)         (90)         (92)                                                
      Inflammation, Chronic                                         1 (1%)                                                          
      Epithelium, Hyperplasia                          2 (2%)                    1 (1%)                                             
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Intestine Small, Jejunum                           (89)         (90)         (91)                                                
      Inflammation, Chronic                                         1 (1%)                                                          
      Epithelium, Hyperplasia                                       1 (1%)                                                          
      Peyer's Patch, Hyperplasia                       2 (2%)                                                                       
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Intestine Small, Ileum                             (88)         (90)         (92)                                                
      Inflammation, Chronic                                         1 (1%)                                                          
      Epithelium, Hyperplasia                                       1 (1%)                                                          
      Peyer's Patch, Hyperplasia, Lymphoid             1 (1%)                                                                       
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
   Liver                                              (99)         (99)         (100)                                               
      Atrophy                                          1 (1%)      10 (10%)      2 (2%)                                             
      Basophilic Focus                                 2 (2%)       1 (1%)                                                          
      Clear Cell Focus                                 1 (1%)      10 (10%)      6 (6%)                                             
      Depletion Glycogen                              20 (20%)     37 (37%)     30 (30%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Eosinophilic Focus                               2 (2%)       3 (3%)       2 (2%)                                             
      Fibrosis                                         1 (1%)       2 (2%)                                                          
      Hematopoietic Cell Proliferation                23 (23%)     35 (35%)     25 (25%)                                            
      Infarct                                          1 (1%)                    1 (1%)                                             
      Inflammation                                     3 (3%)       2 (2%)       1 (1%)                                             
      Necrosis                                         3 (3%)       5 (5%)       4 (4%)                                             
      Pigmentation, Hemosiderin                        1 (1%)       2 (2%)                                                          
      Vacuolization Cytoplasmic                       38 (38%)     43 (43%)     39 (39%)                                            
      Centrilobular, Dilatation                        1 (1%)                                                                       
      Centrilobular, Inflammation, Chronic             1 (1%)                                                                       
      Serosa, Inflammation, Chronic                                 1 (1%)                                                          
   Mesentery                                          (33)         (25)         (36)                                                
      Inflammation, Chronic                            3 (9%)       1 (4%)                                                          
      Necrosis                                        27 (82%)     23 (92%)     31 (86%)                                            
   Pancreas                                           (97)         (95)         (98)                                                
      Atrophy                                         11 (11%)      8 (8%)       6 (6%)                                             
      Hyperplasia                                      1 (1%)                                                                       
      Hyperplasia, Lymphoid                                         1 (1%)                                                          
      Inflammation, Chronic                           18 (19%)     40 (42%)     36 (37%)                                            
      Necrosis                                         1 (1%)                                                                       
      Vacuolization Cytoplasmic                        1 (1%)                                                                       
      Acinus, Atrophy                                                            1 (1%)                                             
      Duct, Cyst                                                    1 (1%)                                                          
      Duct, Dilatation                                                           1 (1%)                                             
   Salivary Glands                                    (99)         (97)         (100)                                               
      Atrophy                                          6 (6%)       6 (6%)       5 (5%)                                             
      Inflammation, Chronic                           52 (53%)     61 (63%)     58 (58%)                                            
   Stomach, Forestomach                               (94)         (93)         (97)                                                
      Inflammation                                                               1 (1%)                                             
      Epithelium, Hyperplasia                          1 (1%)                    3 (3%)                                             
      Serosa, Inflammation, Chronic                                 1 (1%)                                                          
   Stomach, Glandular                                 (93)         (93)         (96)                                                
      Ectopic Liver                                                 1 (1%)                                                          
      Hemorrhage                                       1 (1%)                                                                       
      Inflammation, Chronic                            1 (1%)                    1 (1%)                                             
      Epithelium, Atrophy                                           1 (1%)                                                          
      Epithelium, Hyperplasia                                       1 (1%)       1 (1%)                                             
      Epithelium, Metaplasia, Squamous                              1 (1%)                                                          
      Epithelium, Mineralization                                    1 (1%)                                                          
      Serosa, Inflammation, Chronic                                 1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (2)                                                 
      Aorta, Degeneration                              1 (100%)                                                                     
      Aorta, Metaplasia, Osseous                                                 1 (50%)                                            
   Heart                                              (100)        (99)         (100)                                               
      Cardiomyopathy                                   2 (2%)       4 (4%)       6 (6%)                                             
      Degeneration                                    83 (83%)     92 (93%)     90 (90%)                                            
      Inflammation, Chronic                            1 (1%)       1 (1%)       1 (1%)                                             
      Mineralization                                                1 (1%)                                                          
      Thrombosis                                                    1 (1%)                                                          
      Epicardium, Hyperplasia, Lymphoid                             1 (1%)                                                          
      Epicardium, Mineralization                                    1 (1%)                                                          
      Valve, Thrombosis                                1 (1%)                    3 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (100)        (94)         (97)                                                
      Accessory Adrenal Cortical Nodule                1 (1%)       4 (4%)       1 (1%)                                             
      Angiectasis                                                   2 (2%)                                                          
      Atrophy                                          1 (1%)                                                                       
      Hematopoietic Cell Proliferation                              1 (1%)                                                          
      Hemorrhage                                       1 (1%)                                                                       
      Vacuolization Cytoplasmic                                     1 (1%)                                                          
      Capsule, Hyperplasia                             4 (4%)       5 (5%)       7 (7%)                                             
      Capsule, Inflammation, Chronic                   2 (2%)                                                                       
      Zona Glomerulosa, Atrophy                                     1 (1%)                                                          
      Zona Glomerulosa, Hyperplasia                   11 (11%)      9 (10%)     17 (18%)                                            
      Zona Reticularis, Hematopoietic Cell                                                                                          
          Proliferation                                                          1 (1%)                                             
      Zona Reticularis, Hyperplasia                    6 (6%)       4 (4%)       3 (3%)                                             
   Adrenal Medulla                                    (99)         (94)         (92)                                                
      Hemorrhage                                                                 1 (1%)                                             
   Islets, Pancreatic                                 (97)         (94)         (97)                                                
      Atrophy                                          2 (2%)                    2 (2%)                                             
      Hyperplasia                                     70 (72%)     80 (85%)     78 (80%)                                            
      Infiltration Cellular, Lymphocyte                             1 (1%)                                                          
      Necrosis                                         1 (1%)                                                                       
   Parathyroid Gland                                  (59)         (59)         (69)                                                
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      2 (3%)                    1 (1%)                                             
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic                                                      1 (1%)                                             
   Pituitary Gland                                    (88)         (86)         (84)                                                
      Atrophy                                          1 (1%)                                                                       
      Hemorrhage                                       2 (2%)       1 (1%)                                                          
      Pigmentation, Hemosiderin                        1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Angiectasis                       1 (1%)                                                                       
      Pars Distalis, Hyperplasia                      27 (31%)     28 (33%)     29 (35%)                                            
      Pars Intermedia, Angiectasis                                               1 (1%)                                             
      Pars Intermedia, Hyperplasia                                  1 (1%)                                                          
   Thyroid Gland                                      (100)        (96)         (100)                                               
      Inflammation, Chronic                                                      1 (1%)                                             
      Follicular Cell, Cyst                                                      1 (1%)                                             
      Follicular Cell, Hyperplasia                    57 (57%)     57 (59%)     58 (58%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (89)         (81)         (83)                                                
      Atrophy                                         29 (33%)     26 (32%)     18 (22%)                                            
      Hyperplasia                                      4 (4%)       8 (10%)     10 (12%)                                            
      Inflammation, Chronic                            2 (2%)       1 (1%)                                                          
   Ovary                                              (95)         (97)         (97)                                                
      Angiectasis                                      1 (1%)       1 (1%)                                                          
      Atrophy                                          1 (1%)                                                                       
      Cyst                                            13 (14%)     13 (13%)     15 (15%)                                            
      Hemorrhage                                       2 (2%)       1 (1%)       2 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (1%)                                                          
      Hyperplasia, Tubulostromal                                                 1 (1%)                                             
      Inflammation, Acute                              1 (1%)                                                                       
      Inflammation, Chronic                                         2 (2%)       2 (2%)                                             
      Necrosis                                         1 (1%)       2 (2%)       4 (4%)                                             
      Thrombosis                                       2 (2%)       2 (2%)       1 (1%)                                             
      Periovarian Tissue, Inflammation, Chronic        2 (2%)                                                                       
   Uterus                                             (100)        (100)        (100)                                               
      Amyloid Deposition                               1 (1%)                                                                       
      Diestrus                                                      1 (1%)                                                          
      Hemorrhage                                       2 (2%)                    1 (1%)                                             
      Hydrometra                                       7 (7%)       2 (2%)       2 (2%)                                             
      Inflammation                                     2 (2%)                                                                       
      Inflammation, Chronic Active                     1 (1%)       1 (1%)                                                          
      Endometrium, Angiectasis                         1 (1%)       1 (1%)                                                          
      Endometrium, Hemorrhage                          1 (1%)                                                                       
      Endometrium, Hyperplasia, Cystic                90 (90%)     97 (97%)     98 (98%)                                            
      Serosa, Inflammation, Chronic                    2 (2%)                                                                       
   Vagina                                             (97)         (99)         (99)                                                
      Diestrus                                                      1 (1%)                                                          
      Inflammation, Acute                                           2 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                         2 (2%)       1 (1%)                                             
      Epithelium, Hyperplasia                                       1 (1%)                                                          
      Epithelium, Inflammation, Chronic                             1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (100)        (98)         (100)                                               
      Amyloid Deposition                               1 (1%)                                                                       
      Depletion Cellular                               1 (1%)                                                                       
      Hyperplasia                                     12 (12%)     16 (16%)     11 (11%)                                            
      Infiltration Cellular, Histiocyte                                          1 (1%)                                             
      Myelofibrosis                                   19 (19%)     19 (19%)     26 (26%)                                            
      Pigmentation, Hemosiderin                                     1 (1%)                                                          
   Lymph Node                                         (15)         (21)         (21)                                                
      Ectasia                                                       1 (5%)                                                          
      Hyperplasia                                      2 (13%)      3 (14%)                                                         
      Infiltration Cellular, Plasma Cell                            1 (5%)                                                          
      Bronchial, Hemorrhage                            1 (7%)                                                                       
      Iliac, Hemorrhage, Chronic                                                 1 (5%)                                             
      Iliac, Hyperplasia                                            1 (5%)       3 (14%)                                            
      Iliac, Inflammation, Acute                                    1 (5%)                                                          
      Mediastinal, Hemorrhage                          1 (7%)                                                                       
      Mediastinal, Hyperplasia                         1 (7%)       3 (14%)      4 (19%)                                            
      Renal, Hemorrhage                                1 (7%)                                                                       
      Renal, Hyperplasia                                                         1 (5%)                                             
      Renal, Inflammation, Acute                                    1 (5%)                                                          
   Lymph Node, Mandibular                             (92)         (94)         (93)                                                
      Atrophy                                         12 (13%)      6 (6%)      12 (13%)                                            
      Hemorrhage                                                    1 (1%)                                                          
      Hyperplasia                                     16 (17%)     18 (19%)     10 (11%)                                            
      Hyperplasia, Lymphoid                            1 (1%)                                                                       
      Infiltration Cellular, Histiocyte                                          1 (1%)                                             
      Necrosis                                         2 (2%)                                                                       
      Pigmentation, Hemosiderin                        2 (2%)       2 (2%)       3 (3%)                                             
   Lymph Node, Mesenteric                             (90)         (93)         (93)                                                
      Atrophy                                         12 (13%)     14 (15%)     10 (11%)                                            
      Hemorrhage                                       1 (1%)                                                                       
      Hyperplasia                                      7 (8%)       6 (6%)       6 (6%)                                             
      Inflammation, Chronic                            2 (2%)       2 (2%)       2 (2%)                                             
      Necrosis                                         1 (1%)                    1 (1%)                                             
      Pigmentation, Hemosiderin                                                  1 (1%)                                             
   Spleen                                             (98)         (96)         (98)                                                
      Fibrosis                                                                   1 (1%)                                             
      Hematopoietic Cell Proliferation                52 (53%)     56 (58%)     59 (60%)                                            
      Inflammation, Chronic                                                      1 (1%)                                             
      Necrosis                                         2 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                       41 (42%)     49 (51%)     46 (47%)                                            
      Thrombosis                                       1 (1%)                                                                       
      Capsule, Inflammation, Chronic                                1 (1%)                                                          
      Lymphoid Follicle, Atrophy                       8 (8%)       1 (1%)       4 (4%)                                             
      Lymphoid Follicle, Hyperplasia                  52 (53%)     65 (68%)     64 (65%)                                            
      Red Pulp, Atrophy                                7 (7%)       1 (1%)       3 (3%)                                             
   Thymus                                             (98)         (93)         (99)                                                
      Atrophy                                         66 (67%)     82 (88%)     79 (80%)                                            
      Hemorrhage                                       2 (2%)                                                                       
      Hyperplasia, Lymphoid                                         1 (1%)                                                          
      Inflammation, Chronic                                         1 (1%)       1 (1%)                                             
      Necrosis                                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (93)         (92)         (91)                                                
      Atrophy                                                                    1 (1%)                                             
      Hyperplasia                                      8 (9%)       5 (5%)       7 (8%)                                             
      Inflammation, Chronic                                         1 (1%)                                                          
   Skin                                               (98)         (98)         (100)                                               
      Edema                                            1 (1%)       2 (2%)                                                          
      Inflammation, Chronic                            1 (1%)       4 (4%)                                                          
      Epidermis, Hyperplasia                                                     1 (1%)                                             
      Hair Follicle, Atrophy                           2 (2%)       2 (2%)       1 (1%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                 1 (1%)                                             
      Vulva, Inflammation, Chronic                                               1 (1%)                                             
      Vulva, Ulcer                                     1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (100)        (100)        (100)                                               
      Hyperostosis                                     1 (1%)                    2 (2%)                                             
      Osteoporosis                                     1 (1%)                    1 (1%)                                             
   Skeletal Muscle                                    (9)          (10)         (8)                                                 
      Degeneration                                                  1 (10%)                                                         
      Inflammation, Chronic                            3 (33%)                                                                      
      Metaplasia, Osseous                                           1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)        (99)         (100)                                               
      Hydrocephalus                                    2 (2%)       3 (3%)       2 (2%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (1%)                                             
      Inflammation, Chronic                            1 (1%)       1 (1%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Choroid Plexus, Hyperplasia                                                1 (1%)                                             
      Meninges, Infiltration Cellular, Lymphocyte                   1 (1%)                                                          
      Thalamus, Mineralization                        46 (46%)     53 (54%)     33 (33%)                                            
   Peripheral Nerve                                   (3)          (4)          (4)                                                 
      Inflammation, Chronic                            1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)        (98)         (100)                                               
      Edema                                            9 (9%)       9 (9%)       3 (3%)                                             
      Hemorrhage                                       8 (8%)       3 (3%)       2 (2%)                                             
      Infiltration Cellular                            1 (1%)                                                                       
      Inflammation, Acute                              7 (7%)                    1 (1%)                                             
      Inflammation, Chronic                            9 (9%)      17 (17%)     16 (16%)                                            
      Pigmentation, Hemosiderin                                     1 (1%)                                                          
      Thrombosis                                                    1 (1%)       1 (1%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (1%)                    1 (1%)                                             
      Bronchus, Inflammation, Chronic                               1 (1%)                                                          
   Nose                                               (100)        (100)        (100)                                               
      Hemorrhage                                       1 (1%)                    1 (1%)                                             
      Respiratory Epithelium, Inflammation            22 (22%)     15 (15%)     22 (22%)                                            
   Trachea                                            (100)        (100)        (100)                                               
      Peritracheal Tissue, Inflammation, Chronic                                 1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (6)          (3)                                                 
      Atrophy                                          1 (25%)                                                                      
      Cataract                                                      2 (33%)                                                         
      Cornea, Inflammation, Chronic                    3 (75%)      4 (67%)      3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (98)         (100)                                               
      Congestion                                                                 1 (1%)                                             
      Hydronephrosis                                   1 (1%)       3 (3%)       2 (2%)                                             
      Inflammation                                     1 (1%)       1 (1%)       2 (2%)                                             
      Metaplasia, Osseous                              1 (1%)                                                                       
      Mineralization                                   1 (1%)                                                                       
      Nephropathy                                     88 (88%)     90 (92%)     93 (93%)                                            
      Glomerulus, Amyloid Deposition                   1 (1%)                    1 (1%)                                             
   Urinary Bladder                                    (96)         (96)         (98)                                                
      Atrophy                                                                    1 (1%)                                             
      Degeneration                                                  1 (1%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 88066-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:27:59  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                         2 (2%)       3 (3%)                                             
      Serosa, Inflammation, Chronic                    1 (1%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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