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TDMS Study 88066-01 Pathology Tables

NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96
Route: VAGINAL                                                                                                    Time: 18:44:40

                                                           CORE STUDY




       Facility:  Arthur D. Little Life Science Laboratories

       Chemical CAS #:  9002-89-5

       Lock Date:  07/28/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:44:40  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                         100          100          100                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     24           20           21                                                  
    Accidently Killed                                 10            4            5                                                  
    Moribund Sacrifice                                19           25           13                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           51           61                                                  
  Animals Examined Microscopically                   100          100          100                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (76)         (87)         (79)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (1%)                                             
   Intestine Small, Duodenum                          (88)         (90)         (92)                                                
      Polyp Adenomatous                                1 (1%)       1 (1%)                                                          
   Intestine Small, Jejunum                           (89)         (90)         (91)                                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (1%)                                                                       
   Intestine Small, Ileum                             (88)         (90)         (92)                                                
   Liver                                              (99)         (99)         (100)                                               
      Hepatocellular Carcinoma                        11 (11%)     18 (18%)     20 (20%)                                            
      Hepatocellular Adenoma                          25 (25%)     43 (43%)     36 (36%)                                            
      Hepatocellular Adenoma, Multiple                30 (30%)     13 (13%)     19 (19%)                                            
      Hepatocholangiocarcinoma                                                   2 (2%)                                             
      Histiocytic Sarcoma                              4 (4%)       2 (2%)       1 (1%)                                             
      Serosa, Fibrosarcoma, Metastatic, Skeletal                                                                                    
          Muscle                                       1 (1%)                                                                       
   Mesentery                                          (33)         (25)         (36)                                                
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (4%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                2 (6%)                                             
      Histiocytic Sarcoma                              1 (3%)                                                                       
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle    1 (3%)                                                                       
      Sarcoma                                          1 (3%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (3%)                                                                       
      Yolk Sac Carcinoma, Metastatic, Ovary                                      1 (3%)                                             
   Pancreas                                           (97)         (95)         (98)                                                
      Adenoma                                          1 (1%)                                                                       
      Carcinoma                                                     1 (1%)                                                          
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (1%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (1%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (1%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:44:40  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (99)         (97)         (100)                                               
   Stomach, Forestomach                               (94)         (93)         (97)                                                
      Squamous Cell Carcinoma                          1 (1%)                                                                       
      Squamous Cell Papilloma                          2 (2%)                                                                       
   Stomach, Glandular                                 (93)         (93)         (96)                                                
      Leiomyosarcoma                                                             1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (100)        (99)         (100)                                               
      Hemangiosarcoma                                  1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (100)        (94)         (97)                                                
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (1%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (1%)                                                          
      Histiocytic Sarcoma                              1 (1%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (1%)                                                                       
      Capsule, Adenoma                                              1 (1%)                                                          
      Capsule, Carcinoma                                                         1 (1%)                                             
   Adrenal Medulla                                    (99)         (94)         (92)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (1%)                                             
      Pheochromocytoma Benign                                       2 (2%)                                                          
   Islets, Pancreatic                                 (97)         (94)         (97)                                                
      Adenoma                                                       3 (3%)       1 (1%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (1%)                                             
   Parathyroid Gland                                  (59)         (59)         (69)                                                
      Adenoma                                                                    1 (1%)                                             
   Pituitary Gland                                    (88)         (86)         (84)                                                
      Pars Distalis, Adenoma                          13 (15%)      9 (10%)     10 (12%)                                            
      Pars Intermedia, Adenoma                         1 (1%)                                                                       
   Thyroid Gland                                      (100)        (96)         (100)                                               
      C-Cell, Adenoma                                               1 (1%)                                                          
      Follicular Cell, Adenoma                         8 (8%)       9 (9%)      11 (11%)                                            
      Follicular Cell, Carcinoma                                    1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:44:40  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (95)         (97)         (97)                                                
      Cystadenoma                                      6 (6%)       5 (5%)       3 (3%)                                             
      Granulosa Cell Tumor Benign                      1 (1%)       2 (2%)                                                          
      Hemangiosarcoma                                  1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (1%)       1 (1%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (1%)                                             
      Histiocytic Sarcoma                              3 (3%)       1 (1%)                                                          
      Liposarcoma                                                   1 (1%)                                                          
      Luteoma                                          1 (1%)                    2 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (1%)                                                                       
      Teratoma Benign                                                            1 (1%)                                             
      Yolk Sac Carcinoma                                                         2 (2%)                                             
   Uterus                                             (100)        (100)        (100)                                               
      Carcinoma                                                                  1 (1%)                                             
      Deciduoma NOS                                                              1 (1%)                                             
      Granular Cell Tumor Benign                       1 (1%)       1 (1%)                                                          
      Hamartoma                                        1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (1%)                                                                       
      Histiocytic Sarcoma                              4 (4%)       2 (2%)       1 (1%)                                             
      Leiomyoma                                                     1 (1%)                                                          
      Polyp Stromal                                                 1 (1%)       3 (3%)                                             
      Sarcoma Stromal                                               2 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (1%)                                                                       
      Serosa, Fibrosarcoma, Metastatic, Skeletal                                                                                    
          Muscle                                       1 (1%)                                                                       
   Vagina                                             (97)         (99)         (99)                                                
      Histiocytic Sarcoma                                                        1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (100)        (98)         (100)                                               
      Histiocytic Sarcoma                                           1 (1%)                                                          
   Lymph Node                                         (15)         (21)         (21)                                                
      Liposarcoma                                                   1 (5%)                                                          
      Plasma Cell Tumor Benign                                                   1 (5%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:44:40  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
           Forestomach                                 1 (7%)                                                                       
      Iliac, Histiocytic Sarcoma                       1 (7%)       1 (5%)                                                          
      Inguinal, Fibrosarcoma, Metastatic, Skeletal                                                                                  
          Muscle                                       1 (7%)                                                                       
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Skeletal Muscle                              1 (7%)                                                                       
      Mediastinal, Histiocytic Sarcoma                 1 (7%)                                                                       
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (5%)                                                          
      Renal, Histiocytic Sarcoma                       1 (7%)       1 (5%)                                                          
   Lymph Node, Mandibular                             (92)         (94)         (93)                                                
      Plasma Cell Tumor Benign                                                   1 (1%)                                             
   Lymph Node, Mesenteric                             (90)         (93)         (93)                                                
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (1%)       1 (1%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (1%)                                             
      Histiocytic Sarcoma                              4 (4%)                                                                       
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle    1 (1%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (1%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (1%)                                                                       
   Spleen                                             (98)         (96)         (98)                                                
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (1%)                                                                       
      Histiocytic Sarcoma                              2 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (1%)                                                          
   Thymus                                             (98)         (93)         (99)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (1%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (1%)                                                          
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (1%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (1%)                                             
      Thymoma Benign                                   1 (1%)                    1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (93)         (92)         (91)                                                
      Adenoma                                          1 (1%)                                                                       
      Carcinoma                                                                  1 (1%)                                             
   Skin                                               (98)         (98)         (100)                                               
      Fibrosarcoma                                     1 (1%)                                                                       
      Sarcoma                                          1 (1%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)       2 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (1%)                                                                       
      Subcutaneous Tissue, Pinna, Fibrosarcoma                                   1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:44:40  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (100)        (100)        (100)                                               
      Pelvis, Sarcoma                                                            1 (1%)                                             
   Skeletal Muscle                                    (9)          (10)         (8)                                                 
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (11%)                                                                      
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (13%)                                            
      Rhabdomyosarcoma                                 2 (22%)      2 (20%)      2 (25%)                                            
      Sarcoma                                                                    1 (13%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (11%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)        (99)         (100)                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)        (98)         (100)                                               
      Alveolar/Bronchiolar Adenoma                     6 (6%)       7 (7%)       8 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (3%)       3 (3%)       5 (5%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (1%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (1%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      4 (4%)       2 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                2 (2%)                                             
      Histiocytic Sarcoma                              2 (2%)       1 (1%)                                                          
      Osteosarcoma, Metastatic, Tissue NOS             1 (1%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (1%)       1 (1%)                                             
      Yolk Sac Carcinoma, Metastatic, Ovary                                      1 (1%)                                             
   Nose                                               (100)        (100)        (100)                                               
      Carcinoma                                                     1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (11)         (6)                                                 
      Adenoma                                          4 (80%)      9 (82%)      4 (67%)                                            
      Carcinoma                                        1 (20%)      2 (18%)      1 (17%)                                            
   Zymbal's Gland                                                  (3)                                                              
      Carcinoma                                                     1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:44:40  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (98)         (100)                                               
      Adenoma                                                       1 (1%)                                                          
      Histiocytic Sarcoma                              1 (1%)                                                                       
   Urinary Bladder                                    (96)         (96)         (98)                                                
      Histiocytic Sarcoma                                           1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(100)       *(100)       *(100)                                               
      Histiocytic Sarcoma                              4 (4%)       2 (2%)       1 (1%)                                             
      Lymphoma Malignant                              13 (13%)     14 (14%)     18 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   7                                                               
NTP Experiment-Test: 88066-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:44:40  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      25%                                                    
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            78          82          88                                                   
     Total Primary Neoplasms                          145         160         161                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 67          72          69                                                   
     Total Benign Neoplasms                           103         109         102                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          40          51                                                   
     Total Malignant Neoplasms                         42          51          58                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             11           7           4                                                   
     Total Metastatic Neoplasm                         33          13          15                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           2           1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   8                                                               
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