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TDMS Study 88066-01 Pathology Tables

NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96
Route: VAGINAL                                                                                                    Time: 18:59:20

                                                           CORE STUDY




       Facility:  Arthur D. Little Life Science Laboratories

       Chemical CAS #:  9002-89-5

       Lock Date:  07/28/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1

NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|             
                                           | 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  I  A  A  A  A  +  A  +  +  +  +  I  +  +  +  +  +  A  +  A  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Epithelium, Hyperplasia              |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Peyer's Patch, Hyperplasia           |                               4                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                          3               |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |       X                                                                  |             
      Depletion Glycogen                   |                         2                       2     2                 1|             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  3                          1              2        2               |             
      Infarct                              |                                                                          |             
      Inflammation                         |       4                                                                  |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            | 3  3        1  2        2              3           2        2     3  3  2|             
      Centrilobular, Dilatation            |                                                                          |             
      Centrilobular, Inflammation, Chronic |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +           +  +  +  +                    +           +   |             
      Inflammation, Chronic                |                               3                                          |             
      Necrosis                             |    4           4           4     4  4                    4           4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                    2                     |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                    2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|             
                                           | 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                | 2     1           2  2              2  2     2           2        2     2|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Degeneration                  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Degeneration                         | 2  1  2  1        2     2  2  2  1  2  1  2     2  2     2     1     1  2|             
      Inflammation, Chronic                |       2                                                                  |             
      Valve, Thrombosis                    |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atrophy                              |                4                                                         |             
      Hemorrhage                           |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |                                                 2                        |             
      Zona Reticularis, Hyperplasia        |                                        1                 1               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |          2  2  1     2  2     1  2  3     2  1     2              3     2|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +  I  I  +  I  I  I  +  +  +  +  +  +  +  I  I  +  +  +  I  I  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                1                                                         |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                                         1  2                    3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1     2              2     2  2              2  2     2     2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|             
                                           | 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Atrophy                              |       2                    2  2           2     2  2        1        2   |             
      Hyperplasia                          |                                                                         2|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                           1     1  3           4         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |          4                                                               |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |          4                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |             3                                                            |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hemorrhage              |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 1  2  2  2  2  3     3  2  2  3  3  3  3  1  2  3  3     3  2  3  3  2  2|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Depletion Cellular                   |                                                                          |             
      Hyperplasia                          |       2                                                        2         |             
      Myelofibrosis                        |                                                    2     2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +                                   +                    +   |             
      Hyperplasia                          |             2                                                            |             
      Bronchial, Hemorrhage                |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2           1        2           1     2            |             
      Hyperplasia, Lymphoid                |                               4                                          |             
      Hyperplasia                          |                                                    2     2     2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|             
                                           | 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                   3                                                      |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  I  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Atrophy                              |                      2  3                    1        2                  |             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia                          |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2  3     3        2        3  3  2  2        3  2     2     2         |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                2                          2                    2  2  2  2|             
      Thrombosis                           |                                                                          |             
      Lymphoid Follicle, Atrophy           |                            2                                             |             
      Lymphoid Follicle, Hyperplasia       |       2           2           3  3     2     1     4     4     4        1|             
      Red Pulp, Atrophy                    |                            2              2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  2  3        4  3     2        4     2           3  1  2  4  2  3     3|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Hair Follicle, Atrophy               |                                              2                           |             
      Vulva, Ulcer                         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteoporosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +           +                           |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thalamus, Mineralization             |    2  1        2     2     2           2     1  2              2     1   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                              +                           |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 4| 4| 5| 5| 7| 6| 7| 7| 6| 7| 6| 4| 7| 7| 1| 7| 4| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 1| 5| 3| 0| 8| 9| 3| 2| 5| 3| 3| 5| 3| 4| 7| 2| 2| 1| 3| 4| 3| 6| 1| 2|             
                                           | 4| 8| 9| 1| 0| 3| 5| 8| 9| 7| 0| 0| 5| 1| 3| 6| 9| 9| 0| 1| 1| 0| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3                                         2                  |             
      Hemorrhage                           |             3                                1                           |             
      Infiltration Cellular                |                                                                          |             
      Inflammation, Acute                  |             3                                         1     1            |             
      Inflammation, Chronic                |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Respiratory Epithelium, Inflammation |       2                                               1     1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    2                                                                     |             
      Inflammation                         |             2                                                            |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  2  1  2     1  1  1  1  1  1        2  2  1  1  2     1  1  2  1     1|             
      Glomerulus, Amyloid Deposition       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  I  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|             
                                           | 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Epithelium, Hyperplasia              |                                                 2                        |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                                                       4                  |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                      X   |             
      Clear Cell Focus                     |                                                                          |             
      Depletion Glycogen                   |                               2  2                                       |             
      Eosinophilic Focus                   |                                                          X  X            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                          2                             2  4  2  2      |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |          2                          4                                    |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            | 2        2  2           3  3  3        2  3              2  2  3     3  2|             
      Centrilobular, Dilatation            |                                              2                           |             
      Centrilobular, Inflammation, Chronic |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                             +     +        +   |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                         4                             4     4        4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                             2                       2            |             
      Hyperplasia                          |                         2                                                |             
      Inflammation, Chronic                |                            2                       1     2     1         |             
      Necrosis                             |                                        4                                 |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|             
                                           | 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |          3     2  2        2                    2  3  2  2     3  2  2  2|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Hemorrhage                           |                                              1                           |             
      Inflammation, Chronic                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Degeneration                  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Degeneration                         | 2  2  1  2     2  2  1  2  1  2  3  2  1  1     1  2  3  2  2  2  1      |             
      Inflammation, Chronic                |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                       1                  |             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                 2                        |             
      Capsule, Hyperplasia                 |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |    2  1  2     2                                   2                 2   |             
      Zona Reticularis, Hyperplasia        |                               2                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 1           1  1  2     1  2  2     1     2  2  2  1  3        2  2  3  2|             
      Necrosis                             |                                        4                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  +  I  +  I  I  I  +  I  +  +  +  +  I  I  +  +  I  +  +  +  +  I|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Angiectasis           |                                                             3            |             
      Pars Distalis, Hyperplasia           | 2  4              2     2                          3              2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 2  2     1     2  2           3        2        2  2  4  2     3     1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|             
                                           | 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | I  +  +  +  +  +  +  +  I  +  I  +  +  I  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |       2              1     2                 2  1  2  2  2        1      |             
      Hyperplasia                          |                                                             1        2   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                              2                           |             
      Cyst                                 |          2        4                       1        2     1               |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                     3                                    |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           | 4                          4              3                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |                                                                          |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hemorrhage              |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2     4  2  2  4  1  2  2  2  3  1  4  3     3  3  3  4  4  4  4  3  2|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Depletion Cellular                   |                                                                          |             
      Hyperplasia                          | 2        2                          2                                    |             
      Myelofibrosis                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +                                +                              |             
      Hyperplasia                          |                                                                          |             
      Bronchial, Hemorrhage                |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Renal, Hemorrhage                    |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +|             
      Atrophy                              |             3                                                           2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          | 2                             2  3              2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|             
                                           | 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                        4                                 |             
      Pigmentation, Hemosiderin            |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |       2                                                                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2                                                  2                 1   |             
      Inflammation, Chronic                |                                                 2                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2                             2     3     2     3  2  3     4     2      |             
      Necrosis                             |                                              3                           |             
      Pigmentation, Hemosiderin            | 2           1     3                    2  2     2  2  2        1  2  2   |             
      Thrombosis                           |                                              3                           |             
      Lymphoid Follicle, Atrophy           |             2                       3                                   2|             
      Lymphoid Follicle, Hyperplasia       | 2              3  4     3  3  2  3        2     3  3  3  4  3  3  2      |             
      Red Pulp, Atrophy                    |       2     2                                                           2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     4     4  2  2  4  1  2        4  3  1  3  2     1     1     1  3  4|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  I  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Hair Follicle, Atrophy               |                                                                      3   |             
      Vulva, Ulcer                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteoporosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thalamus, Mineralization             |                         2  1  2  2     2  1              2  2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 1| 7| 3| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 5|             
                             DAY ON TEST   | 4| 2| 7| 0| 5| 3| 3| 0| 3| 2| 3| 3| 9| 9| 2| 3| 2| 3| 3| 2| 2| 2| 3| 8| 1|             
                                           | 0| 1| 5| 9| 0| 1| 0| 6| 1| 9| 0| 0| 6| 5| 9| 9| 5| 0| 1| 9| 9| 9| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2     3                          2                                1|             
      Hemorrhage                           |                                        2                                 |             
      Infiltration Cellular                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2                                                  2  2                  |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Respiratory Epithelium, Inflammation |       1     1                       1  2        1           1  1     1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                              +         |             
      Atrophy                              |                                                                          |             
      Cornea, Inflammation, Chronic        | 2                                                              1         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                              +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Metaplasia, Osseous                  |                2                                                         |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  2     2     2  2     2  1  1  1  2  1  2  1  2  2  1  2  2  2  1  2   |             
      Glomerulus, Amyloid Deposition       |       3                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|             
                                           | 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  A  +  +  A  I  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoid Tissue, Hyperplasia         | 2                                                                        |             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
      Basophilic Focus                     |                                                       X                  |             
      Clear Cell Focus                     |                                                                          |             
      Depletion Glycogen                   |                2                    1  2           2                    2|             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |          1                                                               |             
      Hematopoietic Cell Proliferation     | 3           4              1                       2  1        1        2|             
      Infarct                              |                                                                          |             
      Inflammation                         |          2           2                                                   |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |          1                                                               |             
      Vacuolization Cytoplasmic            | 2                 2  1     2  2                             2            |             
      Centrilobular, Dilatation            |                                                                          |             
      Centrilobular, Inflammation, Chronic |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                    +  +  +     +        +           +  +  +  +     +   |             
      Inflammation, Chronic                | 4                                                                    2   |             
      Necrosis                             |                      4  4  4              4           4  4  4  4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |          2                                2  2        2        2         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 4     2  2                       2  2     2  2                 2         |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|             
                                           | 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |             2                                            2           1   |             
      Inflammation, Chronic                |    2  2     3  2  1  2  2  2        2     2     2     2        2         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Epithelium, Hyperplasia              |                                                       4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                                                  |             
      Aorta, Degeneration                  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                  3                                       |             
      Degeneration                         | 1  1  3  3  2  2  2  2  2  3  1  2  2  3  2  1  2  2  2  2     3     1  2|             
      Inflammation, Chronic                |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Capsule, Hyperplasia                 |                                     2                 2        3         |             
      Capsule, Inflammation, Chronic       | 4                                                                        |             
      Zona Glomerulosa, Hyperplasia        |                            3           2                 3               |             
      Zona Reticularis, Hyperplasia        |                                                       2              2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              | 4                                            3                           |             
      Hyperplasia                          |    1  3  2  1  2  1  2     2  3  3  3  2  3     3  2  4  3  3  3     3  2|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  +  +  I  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  M  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                  3                                       |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |    4     1     2  3     3        4     2           3                    2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1     2  2  1  3  1     2     2  3  2  3     2  3  2  1  2     2        1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|             
                                           | 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +|             
      Atrophy                              |                            2  2  2     2  2  2        1                  |             
      Hyperplasia                          |                         2                                                |             
      Inflammation, Chronic                | 4           4                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Angiectasis                          |                                  3                                       |             
      Atrophy                              |                                                                          |             
      Cyst                                 | 1                          2        4                                    |             
      Hemorrhage                           |                1                                                         |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                  3                                       |             
      Thrombosis                           |                                                          4               |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                      2                                               3   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hemorrhage                           |                                                          3               |             
      Hydrometra                           |                                                                         4|             
      Inflammation, Chronic Active         |                                        2                                 |             
      Inflammation                         |                                                    1                     |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hemorrhage              |                                                                   3      |             
      Endometrium, Hyperplasia, Cystic     | 3  4  3  4  3  3  3  2  4  3  2  3  4  4  3  2  4  4  4  4  2  4     3  4|             
      Serosa, Inflammation, Chronic        | 4                    2                                                   |             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Depletion Cellular                   |                                                                          |             
      Hyperplasia                          | 3           3                                2                          2|             
      Myelofibrosis                        |       2                 2           2  2           1                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                            +           +               |             
      Hyperplasia                          |                                                                          |             
      Bronchial, Hemorrhage                |                                                          2               |             
      Mediastinal, Hemorrhage              |                                                          3               |             
      Mediastinal, Hyperplasia             | 3                                                                        |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                   2                                      2           2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |    4        2              3                          2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|             
                                           | 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |                      2     1  2        3              2     3            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |             4                                                            |             
      Inflammation, Chronic                | 4                                                                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hematopoietic Cell Proliferation     | 4  2  3  3  4        2  2  2  2  4        2     3  3  1  2     2     2   |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |    2           2  2  2  2  1  2        2        2  2  1        2        1|             
      Thrombosis                           |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                             2            |             
      Lymphoid Follicle, Hyperplasia       |    3  3  3  3           2  2  2           3     3  3  3  2     2         |             
      Red Pulp, Atrophy                    |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  2  2     2  1  3        4  3        4     3     3  1  4  2  4      |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  I  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2              2           2                    4  2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             2                                                            |             
      Inflammation, Chronic                |             4                                                            |             
      Hair Follicle, Atrophy               |                                                                          |             
      Vulva, Ulcer                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                        1                                 |             
      Osteoporosis                         |       4                                                                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +  +                    +           +                           |             
      Inflammation, Chronic                |             2                                2                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                       3                  |             
      Inflammation, Chronic                |                                                                          |             
      Thalamus, Mineralization             |    2  2     2  2     2           2  1  2     2  2  1           2        2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |          +  +                                                            |             
      Inflammation, Chronic                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 3| 7| 3| 4| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 9| 3| 3| 9| 2| 4| 2| 2| 3| 3| 5| 5| 3| 3| 8| 6| 6| 2| 5| 7| 2|             
                                           | 9| 1| 0| 1| 2| 1| 0| 0| 9| 6| 5| 9| 1| 0| 5| 2| 0| 0| 2| 6| 5| 9| 7| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |          2                                   3  1                        |             
      Infiltration Cellular                |                               3                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    2                                            2              2         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Respiratory Epithelium, Inflammation |                      1        1                          1  1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Atrophy                              |                            4                                             |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                   2      |             
      Nephropathy                          | 1  2  2  2  2  1  2  2  2  1  2  2  1  1  3  3  1  2  2     2  2  2  1  2|             
      Glomerulus, Amyloid Deposition       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3|            |
                                           | 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  I  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +|  76        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  92        |
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  2.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  89        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  88        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  88        |
      Epithelium, Hyperplasia              |          2                                                               |      2  2.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  89        |
      Peyer's Patch, Hyperplasia           |                                                                          |      2  4.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  88        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Atrophy                              |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Clear Cell Focus                     |                                                                          |      1     |
      Depletion Glycogen                   | 2                 2           1        2  3              3     2     2  2|     20  2.0|
      Eosinophilic Focus                   |                                                                          |      2     |
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                   2     2              2           1                 1   |     23  2.0|
      Infarct                              |    4                                                                     |      1  4.0|
      Inflammation                         |                                                                          |      3  2.7|
      Necrosis                             |                            2                                             |      3  2.7|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |       3     3  3                 2     2           3     2  2            |     38  2.3|
      Centrilobular, Dilatation            |                                                                          |      1  2.0|
      Centrilobular, Inflammation, Chronic |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +  +        +  +  +        +  +        +              +      |  33        |
      Inflammation, Chronic                |                                                                          |      3  3.0|
      Necrosis                             |    4        4  4              4        4  4        4              4      |     27  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
      Atrophy                              |                                  2                 3              2      |     11  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3|            |
                                           | 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |             1     1        2                 2                 1         |     18  1.8|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Atrophy                              | 1                       2                             3                  |      6  1.8|
      Inflammation, Chronic                |       2  3  1  2  2        2  2  2        2  2  2        1  2  1  2  1  1|     52  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  94        |
      Epithelium, Hyperplasia              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  93        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Degeneration                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Cardiomyopathy                       |                            3                                             |      2  3.0|
      Degeneration                         |    2     2  2  2  2  1     2  2  1  3  2  2  2  3  1  2  2     2  2  2  2|     83  1.9|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Valve, Thrombosis                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Atrophy                              |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 |                                     1                                    |      4  2.0|
      Capsule, Inflammation, Chronic       |                         2                                                |      2  3.0|
      Zona Glomerulosa, Hyperplasia        |                                              2                           |     11  2.1|
      Zona Reticularis, Hyperplasia        |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  97        |
      Atrophy                              |                                                                          |      2  3.5|
      Hyperplasia                          |    4  1  2  3  2     2     2  3  2  4  3  2  1  3        2     1  1  2  3|     70  2.1|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  I  +  I  I  I  +  I  +  I  I  I  I  +  +  I  I  +  +  I  I  I  I  I  I|  59        |
      Hyperplasia                          |                                                    1                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  88        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3|            |
                                           | 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                         2                                                |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |             3  3  1              3  4     1        4                 4   |     27  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Follicular Cell, Hyperplasia         |          3  1     2           2  2  1  2  2  3        2  3     2  1  2   |     57  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  89        |
      Atrophy                              |    2                 2  2                             1           1      |     29  1.8|
      Hyperplasia                          |                                                                          |      4  1.8|
      Inflammation, Chronic                |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  95        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                        2                                 |     13  2.2|
      Hemorrhage                           |                            2                                             |      2  1.5|
      Inflammation, Acute                  |                                  4                                       |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      2  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                      3   |      2  3.0|
      Hydrometra                           |          4                 4                                             |      7  3.9|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      2  2.0|
      Endometrium, Angiectasis             |                                        2                                 |      1  2.0|
      Endometrium, Hemorrhage              |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    4  1  3  2  4  4        4  3  3  3  3  4  4     4  2  3     3  3  3  2|     90  2.9|
      Serosa, Inflammation, Chronic        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3|            |
                                           | 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Amyloid Deposition                   |                2                                                         |      1  2.0|
      Depletion Cellular                   |                                                    2                     |      1  2.0|
      Hyperplasia                          |          2              2           2                                    |     12  2.2|
      Myelofibrosis                        |    3                       1  1           3  1     1  3  2     2  1  2   |     19  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +           +  +  +                                      +      |  15        |
      Hyperplasia                          |                            3                                             |      2  2.5|
      Bronchial, Hemorrhage                |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  92        |
      Atrophy                              |                                                    4        2            |     12  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Hyperplasia                          |                   2                    2        2                    2  4|     16  2.4|
      Necrosis                             |                                                                          |      2  3.5|
      Pigmentation, Hemosiderin            |                                                    2                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +|  90        |
      Atrophy                              |                                                    2                     |     12  2.1|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                      2  3|      7  2.3|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hematopoietic Cell Proliferation     |    3  3  4     2  2     3  3  2  3  3  2  2                    2     2   |     52  2.5|
      Necrosis                             |                                                       2                  |      2  2.5|
      Pigmentation, Hemosiderin            |    2        2  1  2           2        2  2        3     2           1  2|     41  1.9|
      Thrombosis                           |                                                                          |      1  3.0|
      Lymphoid Follicle, Atrophy           |       1                                            2        2            |      8  2.0|
      Lymphoid Follicle, Hyperplasia       |    3     3  3  3  2        3  2  3  3  2                 1     3     3  3|     52  2.7|
      Red Pulp, Atrophy                    |                                                             2            |      7  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Atrophy                              |       2     4  4  3     3  1  1  3  1  2     1     3     3  2  1  4  2  1|     66  2.5|
      Hemorrhage                           |                                                 2     2                  |      2  2.0|
      Necrosis                             |                                                       4                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  93        |
      Hyperplasia                          |          3                          2                                    |      8  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3|            |
                                           | 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Hair Follicle, Atrophy               |                                                                          |      2  2.5|
      Vulva, Ulcer                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hyperostosis                         |                                                                          |      1  1.0|
      Osteoporosis                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                         +      |   9        |
      Inflammation, Chronic                |                                                                   1      |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hydrocephalus                        |                                                          2               |      2  2.5|
      Inflammation, Chronic                |                                                                         2|      1  2.0|
      Thalamus, Mineralization             |    2  1     2  2     2     2  2     2     2  2     2                     |     46  1.8|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   3        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Edema                                | 2     2                                                     2            |      9  2.1|
      Hemorrhage                           | 2     2                                                                  |      8  2.0|
      Infiltration Cellular                |                                                                          |      1  3.0|
      Inflammation, Acute                  | 1     1                 2                                   1            |      7  1.4|
      Inflammation, Chronic                |             2                                   2                        |      9  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hemorrhage                           |                                                                         3|      1  3.0|
      Respiratory Epithelium, Inflammation |                            1  1  1           1        1           1      |     22  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   4        |
      Atrophy                              |                                                                          |      1  4.0|
      Cornea, Inflammation, Chronic        |                                     1                                    |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 1| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 2| 3| 3| 0| 2| 3| 0| 1| 8| 3| 2| 8| 3| 3| 2| 5| 7| 6| 3| 6| 3| 0| 2| 3|            |
                                           | 7| 9| 0| 1| 4| 9| 0| 3| 0| 6| 0| 5| 2| 0| 1| 9| 7| 5| 8| 0| 8| 1| 4| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    UNTREATD                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                          +         |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 1  2  1  2  1  2  1     2  2  2  2  2  2  2  2  2  2  1  2     2  2  2  2|     88  1.6|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  96        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|             
                                           | 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             2                                                            |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              1                           |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                           X           X           X      |             
      Depletion Glycogen                   |    2  1                       1        2              2  2  2        2   |             
      Eosinophilic Focus                   |                                  X                                       |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       2     2                 1  2        3  2  2        2           1   |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |       2  3     3     2  2        2     2     2  2  2        2        3   |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                    +                 +  +     +   |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                      4                    4                 4  4     4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2     2                          2                          1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |             2  2  2           1  1  1  2  1  1     1        2     2      |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                | 2     2  2  2  2     2        3  1     2  2  2        1     2  2  2  1  4|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Ectopic Liver                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|             
                                           | 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Atrophy                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
      Epithelium, Mineralization           |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Degeneration                         | 3  2  2  2  3  2  2  2     2  1  2  2  2  2  2  2     1  2  2  2  2     2|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Epicardium, Hyperplasia, Lymphoid    |                                                                          |             
      Epicardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |          3                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Capsule, Hyperplasia                 |          3                                            2                  |             
      Zona Glomerulosa, Atrophy            |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |             2                                2                           |             
      Zona Reticularis, Hyperplasia        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     3  3  2  1  2  3     1  1     2  1  2  3  3  2  2  2  4  3  4  1  3|             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  +  +  +  +  I  I  +  +  I  +  +  +  I  +  I  +  I  I  I  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           | 2     2  2  2                       3     1                    2         |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    2  3  2  3              2  2           1  3  2        2  3     2  3  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|             
                                           | 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Atrophy                              |       2  2  2     3           2        2                             1  1|             
      Hyperplasia                          |                      2                                      2  1         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |          3                    4                 2                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                              4                           |             
      Necrosis                             |             4                                4                           |             
      Thrombosis                           |                                                 3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diestrus                             |                                                                          |             
      Hydrometra                           |                                                                4         |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Angiectasis             |                                           3                              |             
      Endometrium, Hyperplasia, Cystic     | 3  2  4  3  3  3     3  2  2  4  3  4  4  4  3  3  3  4  4  4  3  3  4  4|             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diestrus                             |                                                                          |             
      Inflammation, Acute                  |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                       3                       2        2|             
      Myelofibrosis                        |                                                       1  2              2|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +                             +                    +        +        +|             
      Ectasia                              | 4                                                                        |             
      Hyperplasia                          |                                                                3         |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Iliac, Hyperplasia                   |                                                       3                  |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Mediastinal, Hyperplasia             |                                  4                                       |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                               2              1              2        2   |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|             
                                           | 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                 1  2                     |             
      Hyperplasia                          |                                     2                                2   |             
      Inflammation, Chronic                |             4                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  2  3  3  3  3  3     3        2  3  4  3        3  4        2  3   |             
      Pigmentation, Hemosiderin            | 2     2     2  1           2  1  2  2     3     2     2     2     1      |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                    2                     |             
      Lymphoid Follicle, Hyperplasia       |       2  3  3  3     3     3  4  2  3  3  3  3  2     3  3  3     2  3   |             
      Red Pulp, Atrophy                    |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     1  1     3     4  2     3  4  3  1  1  3  2  3  2  4  1  4  2  2  4|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                   2           2  1         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             3                                                            |             
      Inflammation, Chronic                |             3                                2                           |             
      Hair Follicle, Atrophy               |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                        +         |             
      Degeneration                         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                      1                          2                        |             
      Inflammation, Chronic                |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Thalamus, Mineralization             |    2  2  2                 2  2  2        2                 2     2     2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                            +                                   +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                       1  3                       1                     |             
      Hemorrhage                           |                         1  3                       1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 7| 6| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 5| 9| 1| 1| 8| 2| 1| 5| 7| 7| 0| 3| 3| 2| 4| 6| 2| 3| 3| 1| 3| 3| 3|             
                                           | 9| 0| 8| 0| 7| 3| 8| 9| 3| 4| 5| 5| 5| 0| 1| 2| 6| 2| 9| 1| 1| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                  2        2              1               |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bronchus, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Respiratory Epithelium, Inflammation |    1        1                                1                           |             
                                            __________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Cataract                             |                                                                          |             
      Cornea, Inflammation, Chronic        |          1                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                    +                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                            2                                             |             
      Inflammation                         |             2                                                            |             
      Nephropathy                          | 2  2  2  2  2  1  1  2     3  1  2  1  2  2  2  1  1  1  1  1     1  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|             
                                           | 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                       2                       2      |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |       X                                                  X               |             
      Depletion Glycogen                   |                2              2  1  1  2     2  1     1  1  2     2  1   |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2  2  1              2     1                 2  3  1  1|             
      Inflammation                         |                                                                          |             
      Necrosis                             |    4                                               3                     |             
      Pigmentation, Hemosiderin            |                                        3                                 |             
      Vacuolization Cytoplasmic            |                   2        2  2  1  1     2  2           2  1           2|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +           +  +                    +                       +     +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             | 4                 4  4                    4                       4     4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                | 3     3           3  2  1     2  3     1           2              4      |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2              2                    2                              |             
      Inflammation, Chronic                | 2     2  2        1     2     2  2  1  3        2  2  1  1  2  3     1   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Liver                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|             
                                           | 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Atrophy                  |                                                    3                     |             
      Epithelium, Hyperplasia              |                                        3                                 |             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
      Epithelium, Mineralization           |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Degeneration                         | 2  1  3  2  2  1  2  2  2        2  2  3  3  2  2  2  2  2  2  2  3  1  3|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Epicardium, Hyperplasia, Lymphoid    |                            1                                             |             
      Epicardium, Mineralization           |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       1                                                  1               |             
      Angiectasis                          |                   2                                                      |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Capsule, Hyperplasia                 |                                                                      2   |             
      Zona Glomerulosa, Atrophy            |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |                                        2  2                              |             
      Zona Reticularis, Hyperplasia        |                                                       1  1               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     4  4  3  3  3     1     2  2  3  2     3     2  4  4  3  3        3|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  I  +  +  +  +  I  +  +  I|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  A  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |          1                    1        3     2  1           3        1   |             
      Pars Intermedia, Hyperplasia         |                                                          1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       2  2     2  2     1     3  1     3  1     2     3     1  3        1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|             
                                           | 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  I  +  +  +  +  +  +  I  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1     2        2     1              1  1                 2         |             
      Hyperplasia                          |                                     2           2                        |             
      Inflammation, Chronic                |                                                             4            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                4         |             
      Cyst                                 |                         3           2                 2                  |             
      Hemorrhage                           | 3                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                      4   |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diestrus                             |                                                                          |             
      Hydrometra                           |                                                                          |             
      Inflammation, Chronic Active         |                                              3                           |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  1  2  4  3  3  4  2  4  2  3  3  3  3  3  3  3     2  3  3  2  2  4  4|             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diestrus                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                              3                    2      |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Inflammation, Chronic    |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        2     2                                2              2  1   |             
      Myelofibrosis                        | 2                                                        1        2      |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +        +                       +        +  +        +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                            2                                3            |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                4         |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Hemorrhage                           |                                                    2                     |             
      Hyperplasia                          |          1        2     1                    2        3     1  4         |             
      Pigmentation, Hemosiderin            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|             
                                           | 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |       1                                            4                     |             
      Hyperplasia                          |                                                 2                        |             
      Inflammation, Chronic                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3        3  3     3  3  2              4     3  3  4           3     3   |             
      Pigmentation, Hemosiderin            |          1              1     2           1     1     2  1        3  1   |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       | 3        3        3  3  2     2     2        3  4        1  1  3  3  1   |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  A  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  1     2     3  3     1  3  1  3  4  2  2  4  3  2  2  4  4     2|             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Chronic                |                   1                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Degeneration                         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                         1                                                |             
      Inflammation, Chronic                |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                      1   |             
      Thalamus, Mineralization             | 2  2  1     2  2  2  2  2              2  2  2  2  1  2           2      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   2      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 6| 7| 6| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 6| 3| 2| 3| 9| 6| 4| 0| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 1| 3| 3|             
                                           | 1| 9| 1| 0| 7| 0| 0| 8| 0| 5| 0| 0| 9| 0| 9| 0| 9| 7| 0| 9| 0| 0| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                | 2                                                  2              1      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bronchus, Inflammation, Chronic      |                            3                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Respiratory Epithelium, Inflammation |       1     1                                      1  1           1      |             
                                            __________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                             +                  |             
      Cataract                             |                      2                                                   |             
      Cornea, Inflammation, Chronic        |                         2                             1                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +  +           +                 +                 +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                     4              3                     |             
      Inflammation                         |                                                                          |             
      Nephropathy                          | 2     2  1  1  2  2  2  2     2  2  2  3     2  2  3  2  2  2  2  3  1  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|             
                                           | 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  I  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |          2                                                               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                 2                                             |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     | X        X                                         X                     |             
      Depletion Glycogen                   |    2  2              1                    2        2     2  2  1         |             
      Eosinophilic Focus                   |                                              X                       X   |             
      Fibrosis                             |          2                                                               |             
      Hematopoietic Cell Proliferation     | 2  2        1        2     2              3        2     2  2  1     1   |             
      Inflammation                         |                         2                                                |             
      Necrosis                             |                                     1                                    |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |    2  2  2  2        2           3           3           2     2     2  3|             
      Serosa, Inflammation, Chronic        |                            4                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                    +     +  +     +        +     +  +         |             
      Inflammation, Chronic                |          4                                                               |             
      Necrosis                             |                               4     4  4     4        4     4  4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Atrophy                              |    2                                                              2      |             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Inflammation, Chronic                | 2  2  2  4  2  2     2     4  2                                   2  2   |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                | 2  2  2     2           2     2  2           3     2        2  2     2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Ectopic Liver                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|             
                                           | 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Atrophy                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
      Epithelium, Mineralization           |             1                                                            |             
      Serosa, Inflammation, Chronic        |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          3                                                               |             
      Degeneration                         | 2  2  2  4  3  2  4  2  2  2  2  1  2  2  2  1     2  2  2  2  2  2  2  2|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                   4                                                      |             
      Epicardium, Hyperplasia, Lymphoid    |                                                                          |             
      Epicardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                2                                                         |             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Vacuolization Cytoplasmic            |             4                                                            |             
      Capsule, Hyperplasia                 |                                                    2                     |             
      Zona Glomerulosa, Atrophy            |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |                            2                 2                       2  1|             
      Zona Reticularis, Hyperplasia        |                                                                   1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Hyperplasia                          | 4  2  2  3  2  3  2  3  2     4  4     3  3        2     3  3  3  2  2  1|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  I  +  I  I  +  I  I  I  +  I  +  +  I  +  I  A  +  A  I  +  I  I  I  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  2                 3     2              3  2                    2  2   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 2     1  1     2        3  2     2  2  2  2        2     3     3  2  1  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|             
                                           | 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | I  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  A  +  I  +  +  +  I  +  +|             
      Atrophy                              |                            2     1                       2  1            |             
      Hyperplasia                          |             2                                                            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                      2              2                             4  4   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diestrus                             |                                                                          |             
      Hydrometra                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Angiectasis             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 4  3  3  4  4  4     3  3  3  4  4  4  4  3  2  3  4  3  3  4  2  3  2  3|             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Diestrus                             |                                                                          |             
      Inflammation, Acute                  |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                     3                                    |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                   2     2  3                  |             
      Myelofibrosis                        |       1     2  2     1  1     1                    2                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +                    +                                   +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Plasma Cell   |          4                                                               |             
      Iliac, Hyperplasia                   |                                                                          |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Mediastinal, Hyperplasia             |             3                                                            |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 4     2                                3           2                     |             
      Pigmentation, Hemosiderin            |                                                             1            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|             
                                           | 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |       2        1           2  2  1           2     2     2               |             
      Hyperplasia                          |                         2                                   2            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2  4  3  3     3     4     3  3              3              2     3|             
      Pigmentation, Hemosiderin            | 2     2  2  1  1        2  1  2  2  2  3     2     2     2  2  2  2  2   |             
      Capsule, Inflammation, Chronic       |                            3                                             |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       | 2  2  2     3        3  3  2  2  3  3  3  4        2        3  2  2  2   |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Atrophy                              | 4  3  2  4  2     2  3  4  4     4  1  3  3  4     1     2  3  2  3  2  3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +        +        +                          +              +            |             
      Degeneration                         |                                              1                           |             
      Metaplasia, Osseous                  |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Thalamus, Mineralization             |                2     2        2  2  2  2  1     2  2     2  1     2  2  2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +                                            +                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Edema                                |                         2                             4                  |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 1| 3| 2| 1| 3| 3| 2| 2| 9| 5| 2| 3| 3| 3| 2| 3| 8| 3| 7| 3| 2| 1| 3| 7| 4|             
                                           | 1| 1| 9| 1| 0| 1| 1| 9| 0| 4| 9| 0| 0| 1| 9| 4| 8| 0| 9| 1| 9| 1| 1| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                        1     1     1        2  2         |             
      Pigmentation, Hemosiderin            |                                                                1         |             
      Thrombosis                           |                   3                                                      |             
      Bronchus, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Respiratory Epithelium, Inflammation |             1                                1           1               |             
                                            __________________________________________________________________________|             
   Pleura                                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cataract                             |                                                                          |             
      Cornea, Inflammation, Chronic        |                      1                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                 +                                      +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Nephropathy                          | 1  2  2  3  2  3        2  2  2  2  1  1  2  1     2  2  2  3  2  2  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7|            |
                                           | 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  87        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  93        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  91        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  92        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  90        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  90        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  90        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Atrophy                              |                         1  2           1                          2      |     10  1.8|
      Basophilic Focus                     |                                  X                                       |      1     |
      Clear Cell Focus                     |       X                                         X                        |     10     |
      Depletion Glycogen                   |       2  1  2           2        2     2        3     2     3            |     37  1.8|
      Eosinophilic Focus                   |                                                                          |      3     |
      Fibrosis                             |                         1                                                |      2  1.5|
      Hematopoietic Cell Proliferation     | 2           1           3  2  2           2                              |     35  1.8|
      Inflammation                         |                            3                                             |      2  2.5|
      Necrosis                             |                            3              1                              |      5  2.4|
      Pigmentation, Hemosiderin            |                         2                                                |      2  2.5|
      Vacuolization Cytoplasmic            | 1  3  2           2  3  2     1                 2           3  2         |     43  2.1|
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +           +              +                    +         |  25        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Necrosis                             |       4        4           4              4                    4         |     23  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  95        |
      Atrophy                              |                                     4                                    |      8  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                2        2           4           2     2  2              2|     40  2.1|
      Duct, Cyst                           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
      Atrophy                              |                            2                             1  1            |      6  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7|            |
                                           | 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                | 2     2  2  2  2        2           2     2     2  2  2  2  1  1  1     2|     61  1.9|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  93        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  93        |
      Ectopic Liver                        |                                           3                              |      1  3.0|
      Epithelium, Atrophy                  |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
      Epithelium, Metaplasia, Squamous     |                                     2                                    |      1  2.0|
      Epithelium, Mineralization           |                                                                          |      1  1.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Cardiomyopathy                       |          2  4                          4                                 |      4  3.3|
      Degeneration                         | 2     2  2  3  1  2     3  1  2  2  2  2  2  2  2  2  2  2  2  1  1  1  2|     92  2.0|
      Inflammation, Chronic                |                               2                                          |      1  2.0|
      Mineralization                       |                   1                                                      |      1  1.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Epicardium, Hyperplasia, Lymphoid    |                                                                          |      1  1.0|
      Epicardium, Mineralization           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  94        |
      Accessory Adrenal Cortical Nodule    |                                              1                           |      4  1.3|
      Angiectasis                          |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  4.0|
      Capsule, Hyperplasia                 |                                                          2               |      5  2.2|
      Zona Glomerulosa, Atrophy            |                                  1                                       |      1  1.0|
      Zona Glomerulosa, Hyperplasia        |          2                                                               |      9  1.9|
      Zona Reticularis, Hyperplasia        |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  94        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  94        |
      Hyperplasia                          | 3     3  4  3  2  2  1  3        2  3  2  2  3  1  3  2  3     2     3  2|     80  2.6|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  A  +  I  +  I  I  I  +  I  +  I  I  +  I  +  +  +  +  I  +  +  +  I  +|  59        |
      Cyst                                 |             2                                                            |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  86        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7|            |
                                           | 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                         2                                                |      1  2.0|
      Pars Distalis, Hyperplasia           | 3              2                 4  1     2     3                        |     28  2.1|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  96        |
      Follicular Cell, Hyperplasia         | 2        3  3                    1  2     2  3  2  2  2     3  1        2|     57  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  I  +  +  +  +  +  I  I  +  +  I  +  +  +  +  +  +  I  +  I  I  +  +  +|  81        |
      Atrophy                              |          1        2        2        2  1           2                 1   |     26  1.6|
      Hyperplasia                          |             3                 2                                          |      8  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
      Angiectasis                          |                                                                          |      1  4.0|
      Cyst                                 |                                           3     2           2            |     13  2.7|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  4.0|
      Necrosis                             |                                                                          |      2  4.0|
      Thrombosis                           |                                           4                              |      2  3.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Diestrus                             |             X                                                            |      1     |
      Hydrometra                           |             4                                                            |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Endometrium, Angiectasis             |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 4  2  4  3  3  3  2  2  2  2  2  3  3  1  2  3  3  2  4  3  4  4  2  3  4|     97  3.1|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Diestrus                             |             X                                                            |      1     |
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
      Epithelium, Inflammation, Chronic    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hyperplasia                          |                            3  2                                          |     16  2.1|
      Myelofibrosis                        | 3        2                          1        1                    1     1|     19  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7|            |
                                           | 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +     +                 +                  |  21        |
      Ectasia                              |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      3  2.7|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
      Iliac, Inflammation, Acute           |                               2                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      3  3.7|
      Renal, Inflammation, Acute           |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  94        |
      Atrophy                              |                   2        2                             1              2|      6  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                               2                 3  4                     |     18  2.3|
      Pigmentation, Hemosiderin            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  93        |
      Atrophy                              |          1                             3                                 |     14  1.9|
      Hyperplasia                          |                                                          2               |      6  2.0|
      Inflammation, Chronic                |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  96        |
      Hematopoietic Cell Proliferation     | 3     2  3  3  3           3  2     4  3  4     1  4  3  3     3     4  3|     56  3.0|
      Pigmentation, Hemosiderin            | 2     2                 2  2     2        2  2              1           2|     49  1.8|
      Capsule, Inflammation, Chronic       |                                                                          |      1  3.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
      Lymphoid Follicle, Hyperplasia       | 3     3  3  3  3        3     2              2  3  3  3  3  3  3  3     2|     65  2.7|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  93        |
      Atrophy                              | 2  2  3  3  4  4  4  2  2     1  2        1  3  2     1     3  2  2  4  1|     82  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  I  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  92        |
      Hyperplasia                          |                                                                          |      5  1.8|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Edema                                |                                                                          |      2  2.5|
      Inflammation, Chronic                |                               4                    4                     |      4  3.3|
      Hair Follicle, Atrophy               |                                                                         2|      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7|            |
                                           | 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                    +     +              +|  10        |
      Degeneration                         |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Hydrocephalus                        |                                                                          |      3  1.3|
      Inflammation, Chronic                |                               1                                          |      1  1.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Thalamus, Mineralization             | 2     2  2                          2  2  1  2  2  2  2  2  1  1  2      |     53  1.9|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Edema                                |                   2  2                                                   |      9  2.1|
      Hemorrhage                           |                                                                          |      3  1.7|
      Inflammation, Chronic                | 2           2           3                       2              1        2|     17  1.7|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Bronchus, Inflammation, Chronic      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Respiratory Epithelium, Inflammation |    1                       1                                   1     1   |     15  1.0|
                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                +         |   6        |
      Cataract                             |                                                                2         |      2  2.0|
      Cornea, Inflammation, Chronic        |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |  11        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hydronephrosis                       |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 7| 5| 3| 7| 5| 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 3| 1| 2| 3| 3| 2| 3| 1| 2| 4| 4| 2| 2| 4| 2| 2| 2| 4| 2| 9| 2| 7| 2| 3| 7|            |
                                           | 0| 4| 9| 0| 0| 9| 2| 4| 9| 8| 2| 9| 8| 8| 9| 9| 9| 8| 9| 4| 9| 5| 2| 1| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    VEHICLE                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  2.0|
      Nephropathy                          | 2  1  2  2  2  2        2  3  2  2  3  2  3  2  2  2  1  3  2  2  1  3  2|     90  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  96        |
      Degeneration                         |                                                          1               |      1  1.0|
      Inflammation, Chronic                | 2                             2                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  I  +  +  +  +  +  +  +  +  +  I  A  +  +  +  A  +  +  +  A  +  +  I|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Depletion Glycogen                   |    2     2     2              2  3              1        1  1     2  1  2|             
      Eosinophilic Focus                   |                      X                                                   |             
      Hematopoietic Cell Proliferation     | 2              1              1              3                          2|             
      Infarct                              |       3                                                                  |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                        4                                 |             
      Vacuolization Cytoplasmic            | 4  2     2     2           3  2  1              2  3     2  2     2  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +     +        +        +                          +  +        +   |             
      Necrosis                             | 4     4     4                 4                          4  4        4   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Atrophy                              |                                              3                           |             
      Inflammation, Chronic                |    2  1     2     1        3  2     2        3              2     3      |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
      Inflammation, Chronic                | 2     2  2  2  3  1           2     2  1  2  2        2  2        2  2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation                         |                                                                          |             
      Epithelium, Hyperplasia              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                                       |             
      Aorta, Metaplasia, Osseous           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3                                   2                                    |             
      Degeneration                         | 2  2  2  2  2  2  2     2  3  2  2  2  3  2  3  2     3  1  2  2  1  2  2|             
      Inflammation, Chronic                |                                                                          |             
      Valve, Thrombosis                    |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              2                           |             
      Capsule, Hyperplasia                 |                   2                             2        4               |             
      Zona Glomerulosa, Hyperplasia        | 2                          1     2     2                                 |             
      Zona Reticularis, Hematopoietic Cell |                                                                          |             
          Proliferation                    |                                                                          |             
      Zona Reticularis, Hyperplasia        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Atrophy                              |                            4                                             |             
      Hyperplasia                          | 4  2  2  3  4  1  2           2  3        2  3  3     3  3  2        2  2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  I  +  I  +  I  I  I  +  +  +  +  I  +  I  I  I  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  I  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 1  2                          2  2                                1      |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         |    2  2     2  3  2     3  3  1  1  1     2     2     2  2  2     1  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  I  +  +  A  +  +  +|             
      Atrophy                              |       2                    1  3     2           2                       1|             
      Hyperplasia                          |          1                                               1           1   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Cyst                                 |       2  3                                            2                  |             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Tubulostromal           |                                  3                                       |             
      Inflammation, Chronic                |                                        4     4                           |             
      Necrosis                             |                                                          2               |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  4  4  4  2  2  2  2  2  4  4  4  4  4  4  3  2  4  3  3  3  3  4  4|             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     1                                      2           2               |             
      Infiltration Cellular, Histiocyte    |             2                                                            |             
      Myelofibrosis                        |       1  3                 2           1  1                 2     2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +     +                 +                              |             
      Iliac, Hemorrhage, Chronic           |                   4                                                      |             
      Iliac, Hyperplasia                   |                                                                          |             
      Mediastinal, Hyperplasia             |                                           3                              |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Atrophy                              |          2           1     2                                             |             
      Hyperplasia                          |                2                          4                 3            |             
      Infiltration Cellular, Histiocyte    |             2                                                            |             
      Pigmentation, Hemosiderin            |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Atrophy                              |          2        2                                2                     |             
      Hyperplasia                          |                                           4  3           1        1      |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                        2                                 |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   2      |             
      Hematopoietic Cell Proliferation     | 3  3  2     3     3  3        3     3        4  1     4  2  2     3     2|             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            |    2  2  2        2        2  1     2           1           2     1     1|             
      Lymphoid Follicle, Atrophy           |                            2                       2                     |             
      Lymphoid Follicle, Hyperplasia       | 3  3     3  3  3  3           3  3  3     4  3  2     3  4  2     3     3|             
      Red Pulp, Atrophy                    |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  3  1  1     1  2  2     4  2     1  3     1  1  2  1  2  1     1  1  2|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia               |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Vulva, Inflammation, Chronic         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |          2                                                               |             
      Osteoporosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                   +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Choroid Plexus, Hyperplasia          |                                                                          |             
      Thalamus, Mineralization             |    2           2                             2  2     2  2     2        2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +                                   +                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                   +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    1                     |             
      Hemorrhage                           |                                           2                              |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             2  2                             2                           |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       3                  |             
      Respiratory Epithelium, Inflammation |                   1           1                    1                    1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cornea, Inflammation, Chronic        |                                              1                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 7| 8| 6| 3| 3| 2| 5| 2| 4| 3| 1| 2| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 0| 1| 9| 2| 2| 8| 1| 0| 4| 1| 9| 6| 0| 3| 9| 0| 0| 4| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                       3                  |             
      Hydronephrosis                       |                                                       2                  |             
      Inflammation                         |                                                                          |             
      Nephropathy                          | 1  1  2  2  2  1  2  1     1  2  1  2  2  2  2  3  1  2  2  2  1  2  2  2|             
      Glomerulus, Amyloid Deposition       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|             
                                           | 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Chronic                         |                         3                                                |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             
      Clear Cell Focus                     |                                                                          |             
      Depletion Glycogen                   |                1           2     2                          1            |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |    2     2  2  1                                            1  1        1|             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                              3                           |             
      Vacuolization Cytoplasmic            | 2           3              2              1        2        2  1        2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +           +     +        +              +           +        +  +   |             
      Necrosis                             | 4              4     4                       4                    4  4   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
      Inflammation, Chronic                | 2  2  2                       3                             1     3  2   |             
      Acinus, Atrophy                      |    3                                                                     |             
      Duct, Dilatation                     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              3                           |             
      Inflammation, Chronic                | 2  2  3  2  2     1  2  4  1                    1     1     1  2  2      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Epithelium, Hyperplasia              |                2                                      1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Metaplasia, Osseous           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|             
                                           | 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Degeneration                         | 2  2  2     2  2  3  2  2  2  1  2     2        1  2  2     2  2  2  2  2|             
      Inflammation, Chronic                |                                                                          |             
      Valve, Thrombosis                    |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |                         2        2                 2  2                  |             
      Zona Reticularis, Hematopoietic Cell |                                                                          |             
          Proliferation                    |                                                                          |             
      Zona Reticularis, Hyperplasia        |                                                    1                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              4                           |             
      Hyperplasia                          | 2     3        2     3  3  2     3  2           3  4  2  3  3  1  3  2  2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  I  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  I  +  I  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                         3                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |             1     4     2        4                    3                 2|             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         3                                                |             
      Follicular Cell, Cyst                |                                                    3                     |             
      Follicular Cell, Hyperplasia         |             1  3        3  3  2  2                    3  3  2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  I  +  +  +  +  +  +  +  +  I  I  I  +  +  +  +  +  I  +  +|             
      Atrophy                              |                               1                                         2|             
      Hyperplasia                          |             2     2                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                2                          3           2|             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Tubulostromal           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                       2                  |             
      Thrombosis                           |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|             
                                           | 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |    3                                                                     |             
      Endometrium, Hyperplasia, Cystic     | 2  4  2  1  2  4  3  2  4  4  4  4  2  2  2  4  4  2  3  2  4  4  3  3  3|             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Myelofibrosis                        | 1              1  2  1  2  1     2                    1        2     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +        +                    +     +  +  +               |             
      Iliac, Hemorrhage, Chronic           |                                                                          |             
      Iliac, Hyperplasia                   |                         3                                                |             
      Mediastinal, Hyperplasia             |                                                    3                     |             
      Renal, Hyperplasia                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                         2        1                                       |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
      Hyperplasia                          |                         2                                                |             
      Inflammation, Chronic                |                                                       3                  |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    3  3  2     3  3  3  4     4  3  2  3        3  2  3     3  2  2  3   |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            | 1           2                    1              2           1  2  1  2  1|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       | 3  3  3  2        3  3  3  1  2  3  2  2        3  3        3  2  3  3   |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  2  4  3  4     3  1        1  1  3  1     4  4  4  4     3  1  4  4   |             
      Inflammation, Chronic                |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  I  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                         2        2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|             
                                           | 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia               |                                                                   2      |             
      Hair Follicle, Atrophy               |                            2                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Vulva, Inflammation, Chronic         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                         1                                                |             
      Osteoporosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +     +        +     +                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                    3                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Choroid Plexus, Hyperplasia          |                                                                          |             
      Thalamus, Mineralization             |          2     2        2        2           2                    2     2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2                       3                                                |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Respiratory Epithelium, Inflammation |    1  1              1                       1              1     1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Cornea, Inflammation, Chronic        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 6| 7| 7| 5| 7| 5| 3| 1| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 4| 6| 3| 2| 9| 3| 3| 5| 3| 0| 2| 1| 2| 9| 4| 9| 2| 2| 3| 2| 2| 3|             
                                           | 9| 9| 4| 2| 1| 1| 9| 7| 0| 1| 3| 0| 7| 4| 2| 7| 0| 0| 6| 1| 9| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Nephropathy                          | 2  3  2  2  2  2  1  2  3  2  2  2  2  2  1  2  2  2     2  2  1  2  2  1|             
      Glomerulus, Amyloid Deposition       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                                                               |             
      Inflammation, Chronic                |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|             
                                           | 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
      Clear Cell Focus                     |                X                                X     X           X      |             
      Depletion Glycogen                   | 2     2        2           1     2                                   2   |             
      Eosinophilic Focus                   | X                                                                        |             
      Hematopoietic Cell Proliferation     | 1     2                    2     2                    2              1   |             
      Infarct                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                        3                    2            |             
      Vacuolization Cytoplasmic            |          2  2        1     1     2              2  3              2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +           +        +           +  +  +  +            |             
      Necrosis                             |    4              4           4                    4  4  4  4            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                        2               |             
      Inflammation, Chronic                |       2  1  2  1        2                 2  2  2  1           2  2     2|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2  3  2            |             
      Inflammation, Chronic                |    2  2  1  1  1  2     2     1  1  2        2     2  1        2  1  2  2|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         2|             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
      Aorta, Metaplasia, Osseous           |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|             
                                           | 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                               3        3              3                  |             
      Degeneration                         | 2  2  2  1  1  2  2     2  1  2  2  1  3  2  2  1  2  2  2  3  2  2  2  2|             
      Inflammation, Chronic                |                                                             4            |             
      Valve, Thrombosis                    |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Capsule, Hyperplasia                 |       2                                                        2         |             
      Zona Glomerulosa, Hyperplasia        | 2                                                     2  1  2     2  2   |             
      Zona Reticularis, Hematopoietic Cell |                                                                          |             
          Proliferation                    |                                                          3               |             
      Zona Reticularis, Hyperplasia        | 1                                         1                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 2  3  2  1  3  4  3     1  2  1  3  2  2  2     1  3  4  2  4  3  3     3|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  I  +  I  +  +  I  +  +  I  I  +  +  +  I  I  +  +  +  I  +  I  I  +  +|             
      Hyperplasia                          |                                                                         3|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |       2        1        4        3        1  3        2     1  3  1  3   |             
      Pars Intermedia, Angiectasis         |          3                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicular Cell, Cyst                |                                                                          |             
      Follicular Cell, Hyperplasia         | 1     3     3  2        4  3  2  1  2     2  3  2     1     1     2  1  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I  I  +  +  +  +  +|             
      Atrophy                              | 1  1              1     2  2                    2                        |             
      Hyperplasia                          |                                  1     2           2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Cyst                                 |                         2              2                          2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Tubulostromal           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |          2                                                  2            |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|             
                                           | 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2                                                                        |             
      Hydrometra                           |                                                                         3|             
      Endometrium, Hyperplasia, Cystic     | 3  4  4  3  2  4  2     2  4  2  4  2  3  3  4  3  3  3  1  3  3  3  3  4|             
                                            __________________________________________________________________________|             
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1           1        1        2               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Myelofibrosis                        |       1        2        2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +                                      +           +        +         |             
      Iliac, Hemorrhage, Chronic           |                                                                          |             
      Iliac, Hyperplasia                   |    2                                                                     |             
      Mediastinal, Hyperplasia             |                                                                2         |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1        2     2                       2  3               |             
      Hyperplasia                          |       2           2                                                      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                               1                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Atrophy                              |                                  1                       2     2         |             
      Hyperplasia                          |       1                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    3  2  3  3           2  2           4  1  2  1  3  3  4  3  2     3  2|             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            |    1  2     1  1        2  2  2  2  2     2  2  1              2  2     2|             
      Lymphoid Follicle, Atrophy           |                                                          4               |             
      Lymphoid Follicle, Hyperplasia       |    2  3  2  2  2        3  2  2  1           3  1  3        3  3     3   |             
      Red Pulp, Atrophy                    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  1  4  1  2  4  2     1  4     3     2  4  4  2  4  4  4  2  2     4|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  I  I  I  +  I  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2               |             
      Hyperplasia                          |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|             
                                           | 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia               |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Vulva, Inflammation, Chronic         |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Osteoporosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                           1                              |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Choroid Plexus, Hyperplasia          |                                                                          |             
      Thalamus, Mineralization             | 2     2        2  2           2                                2     2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       2        2        2     2                       2  3     2        2|             
      Thrombosis                           |                   3                                                      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Respiratory Epithelium, Inflammation | 1           1     1           1        1                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Cornea, Inflammation, Chronic        |                            1                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                       +                                      +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 2| 8| 7| 3| 3| 0| 3| 4| 2| 2| 3| 7| 3| 5| 3| 0| 3| 3| 3| 2|             
                                           | 0| 1| 1| 0| 9| 9| 6| 2| 0| 0| 1| 0| 6| 0| 9| 0| 5| 0| 8| 8| 8| 0| 1| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    25%                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Hydronephrosis                       | 3                                                                        |             
      Inflammation                         |                   3                                         3            |             
      Nephropathy                          | 3  1  1  3  2  1     3  2  3     2  1  2  1  1  2  2  1  3     2  2  2  2|             
      Glomerulus, Amyloid Deposition       |                      3                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2|            |
                                           | 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    25%                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  I  +  +  A  A  I  A  +  +  A  +  +  +  I  +  +|  79        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  97        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  96        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  96        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  92        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  91        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  92        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Atrophy                              |                                                                          |      2  2.0|
      Clear Cell Focus                     |             X                                   X                        |      6     |
      Depletion Glycogen                   |    1  2  1  3        2        3  2              2                    2   |     30  1.8|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |       2  1                 1     2                       2        2  2   |     25  1.6|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation                         |                                                          2               |      1  2.0|
      Necrosis                             |                                                                          |      4  3.0|
      Vacuolization Cytoplasmic            |                   2  1     2        2  2              3  2  2        2   |     39  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +  +                 +     +  +              +  +        +     +  +|  36        |
      Necrosis                             |    4  4  4                 2     4  4              4  4        4     4  4|     31  3.9|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  98        |
      Atrophy                              |       2                                                        2         |      6  2.3|
      Inflammation, Chronic                | 2  2        2                 2  2                       2           2   |     36  2.0|
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Atrophy                              |                                                                          |      5  2.4|
      Inflammation, Chronic                | 2     2     2  2              2  2  2     1     1        2        2  2   |     58  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  97        |
      Inflammation                         |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  96        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2|            |
                                           | 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    25%                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Aorta, Metaplasia, Osseous           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Cardiomyopathy                       |                2                                                         |      6  2.7|
      Degeneration                         | 2  2  3  1  2  2  2  2  2     2  2  2  2  2  2  2  2     2  1  2  2  2  2|     90  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Valve, Thrombosis                    |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  97        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 |                         2                                         2      |      7  2.3|
      Zona Glomerulosa, Hyperplasia        | 2     2           1                                                      |     17  1.8|
      Zona Reticularis, Hematopoietic Cell |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Zona Reticularis, Hyperplasia        |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +|  92        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  97        |
      Atrophy                              |                                                                          |      2  4.0|
      Hyperplasia                          | 3  3  1  1  3  3  2  3  2     2  3  3     2  2  1  3     2  2  2  3  2  3|     78  2.4|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  I  +  I  I  I  +|  69        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  I  +  +  +  +  +  +  I  I  +  +  M  +  +  +  +  +  +  +  M  +  I|  84        |
      Pars Distalis, Hyperplasia           |       2     3        2  2                       3  4                 2   |     29  2.3|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Follicular Cell, Cyst                |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |    2  2                 2     2     2              1        3  2  3  2  4|     58  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2|            |
                                           | 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    25%                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  I  I  +  +  +  I  +  +  +  +  +  +  +  I  +  +  I|  83        |
      Atrophy                              |                3     2              1        3                           |     18  1.8|
      Hyperplasia                          |                                  1                                   2   |     10  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
      Cyst                                 | 2                                         2     3        3              3|     15  2.4|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Tubulostromal           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  4.0|
      Necrosis                             |                                                                          |      4  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrometra                           |                                                                          |      2  3.0|
      Endometrium, Hyperplasia, Cystic     | 4  3  3  3  3  3  2  3  4  2  3  3  3  3  2  3  3  3  1  4  4     3  3  3|     98  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hyperplasia                          |                                              2                 2         |     11  1.6|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Myelofibrosis                        |                               1     1  1  1                             3|     26  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +                       +           +              +  +        +|  21        |
      Iliac, Hemorrhage, Chronic           |                                                                          |      1  4.0|
      Iliac, Hyperplasia                   |                                  4                                       |      3  3.0|
      Mediastinal, Hyperplasia             |          3                                                               |      4  2.8|
      Renal, Hyperplasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  I  +  I  +  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +|  93        |
      Atrophy                              |                            1  2        1                             2   |     12  1.8|
      Hyperplasia                          |       2        2                 3                                       |     10  2.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                               1                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +|  93        |
      Atrophy                              |                               2     1                                2   |     10  1.9|
      Hyperplasia                          |                                                                          |      6  2.0|
      Inflammation, Chronic                |                                                          2               |      2  2.5|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2|            |
                                           | 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    25%                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       3     2  4              2           3     3           3     3  2   |     59  2.7|
      Inflammation, Chronic                |                                                          4               |      1  4.0|
      Pigmentation, Hemosiderin            | 2  2     2  2  1     1  2        2                    2           2  2   |     46  1.7|
      Lymphoid Follicle, Atrophy           |                   2                                                      |      4  2.5|
      Lymphoid Follicle, Hyperplasia       | 3  3  2     3           3     3  3  1     3     3  3        3     3  2   |     64  2.7|
      Red Pulp, Atrophy                    |                   2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Atrophy                              | 4     3  4  1  4        3  1  2  2  4  3  1     2  4  4  4  4     1  2  2|     79  2.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  91        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |          1                                               3  1  3         |      7  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Hair Follicle, Atrophy               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                         4|      1  4.0|
      Vulva, Inflammation, Chronic         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hyperostosis                         |                                                                          |      2  1.5|
      Osteoporosis                         |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   8        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hydrocephalus                        |                                                                          |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                 1                        |      1  1.0|
      Choroid Plexus, Hyperplasia          |    2                                                                     |      1  2.0|
      Thalamus, Mineralization             |    2  2     2  2     2  2     2  2     2                 2        1      |     33  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                            +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                            +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 88066-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         POLYVINYL ALCOHOL                                     Date: 08/14/96  
Route: VAGINAL                                                                                                    Time: 18:59:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 3| 3| 1| 0| 3| 3| 1| 3| 3| 0| 8| 3| 2| 2| 2| 3| 2| 3| 2| 3| 2| 2|            |
                                           | 9| 9| 0| 1| 1| 9| 4| 0| 0| 4| 1| 1| 4| 8| 0| 4| 9| 9| 7| 1| 1| 9| 1| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    25%                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                   2                                   2                  |      3  1.7|
      Hemorrhage                           |                   2                                                      |      2  2.0|
      Inflammation, Acute                  |                   1                                                      |      1  1.0|
      Inflammation, Chronic                | 2                                2                       3               |     16  2.2|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Respiratory Epithelium, Inflammation |                   1     1           1     1        1     1     1         |     22  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cornea, Inflammation, Chronic        |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Congestion                           |                                                                          |      1  3.0|
      Hydronephrosis                       |                                                                          |      2  2.5|
      Inflammation                         |                                                                          |      2  3.0|
      Nephropathy                          | 2  1  2  1  2  2  1  2  2  1  1  2  1  1  2  2  1  2     4  2     1  1  2|     93  1.8|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Atrophy                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                   2                                                      |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
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