TDMS Study 88066-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: A. D. Little DATE: 08/30/94
EXP: 88066 POLYVINYL ALCOHOL TIME: 06:59:56
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: VAGINAL NTP C#: 88066
CONT: N01-ES-15330 CAS: 9002-89-5
PATHOLOGIST: GOAD, MARY
POLYVINYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATDCONTROL |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 43 CENSORED DEATHS 10 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 175 357 365 400 410 473 476 529 538 539 |
| 581 592 595 606 625 634 640 643 646 652 |
| 655 655 657 657 659 666 668 668 675 682 |
| 682 686 690 696 703 704 709 711 714 718 |
| 721 725 725 |
| CENSORED DEATHS |
| 67 110 168 350 441 483 511 530 595 704 |
| |
|--------------------------------------------------------------------------------|
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 45 CENSORED DEATHS 4 TERMINAL 51 |
| |
| UNCENSORED DEATHS |
| 205 532 542 548 548 548 588 588 609 611 |
| 611 611 613 620 627 634 637 639 640 643 |
| 646 654 654 658 661 668 671 675 675 675 |
| 675 679 679 690 690 690 694 705 711 711 |
| 717 721 722 722 728 |
| CENSORED DEATHS |
| 313 314 314 462 |
| |
==================================================================================
POLYVINYL ALCOHOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATDCON|ROL100.0 99.0 99.0 96.9 94.8 92.7 89.4 86.2 72.9 52.9 |
|U | |
| | |
|VEHICLE | 100.0 100.0 99.0 99.0 99.0 99.0 96.9 91.7 74.0 53.1 |
|CONTROL | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATDCONTROL VEHICLE |
| U CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.9% 53.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.980N P=0.980N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 611.7 639.2 |
|NATURAL DEATHS (C) | (18.4) (12.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.2 673.5 |
|(STANDARD ERROR) | (14.3) ( 9.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)