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TDMS Study 88066-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: A. D. Little                                              DATE: 08/30/94  
EXP: 88066                    POLYVINYL ALCOHOL                TIME: 06:59:56  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: VAGINAL                     NTP C#: 88066   
CONT: N01-ES-15330                                             CAS: 9002-89-5  
PATHOLOGIST: GOAD, MARY                                                        
                                 POLYVINYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATDCONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 43     CENSORED DEATHS 10   TERMINAL 47        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      175   357   365   400   410   473   476   529   538   539                 |
 |      581   592   595   606   625   634   640   643   646   652                 |
 |      655   655   657   657   659   666   668   668   675   682                 |
 |      682   686   690   696   703   704   709   711   714   718                 |
 |      721   725   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      67    110   168   350   441   483   511   530   595   704                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 45     CENSORED DEATHS 4    TERMINAL 51        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      205   532   542   548   548   548   588   588   609   611                 |
 |      611   611   613   620   627   634   637   639   640   643                 |
 |      646   654   654   658   661   668   671   675   675   675                 |
 |      675   679   679   690   690   690   694   705   711   711                 |
 |      717   721   722   722   728                                               |
 |  CENSORED DEATHS                                                               |
 |      313   314   314   462                                                     |
 |                                                                                |
 ==================================================================================
                                 POLYVINYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATDCON|ROL100.0  99.0  99.0  96.9  94.8  92.7  89.4  86.2  72.9  52.9      |
 |U          |                                                                    |
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0  99.0  99.0  99.0  99.0  96.9  91.7  74.0  53.1      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                UNTREATDCONTROL           VEHICLE               |
 |                                U                         CONTROL               |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.9%                     53.1%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.980N                  P=0.980N              |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       611.7                     639.2                 |
 |NATURAL DEATHS (C)      |       (18.4)                    (12.6)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       645.2                     673.5                 |
 |(STANDARD ERROR)        |       (14.3)                    ( 9.8)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)