TDMS Study 88070-03 Pathology Tables
NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 Facility: Battelle Northwest Chemical CAS #: 115-11-0007 Lock Date: 10/05/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Mesentery | + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Bilateral, Carcinoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Leukemia Mononuclear | X | Polyp Stromal | X X X | Polyp Stromal, Multiple | | |__________________________________________________________________________| Vagina | + | Polyp | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Lymph Node | + + + + | Pancreatic, Leukemia Mononuclear | X X X | Renal, Leukemia Mononuclear | | Renal, Sarcoma | X | |__________________________________________________________________________| Lymph Node, Bronchial | + M + + M + + + + M + M + + + M M + + M + M + M +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + M + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | M + + + M + + + + + M + + + + + + + M + + + + + +| Leukemia Mononuclear | X X X X X X | Plasma Cell Tumor Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X X | Fibroadenoma, Multiple | X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrous | | Histiocytoma | X | Subcutaneous Tissue, Hemangioma | X | Subcutaneous Tissue, Sarcoma | X | Subcutaneous Tissue, Pinna, Melanoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Carcinoma, Metastatic, Mammary Gland | X | Leukemia Mononuclear | X X X X X X X X X X X | Plasma Cell Tumor Malignant, | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Metastatic, Lymph Node, | | Mediastinal | | Mediastinum, Plasma Cell Tumor | | Malignant, Metastatic, Lymph | | Node, Mediastinal | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Renal Tubule, Carcinoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + A A + + + + + + + + + + + + + + + + + + + I +| 47 | Polyp Adenomatous | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + A A + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + A + + + +| 46 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 18 | |__________________________________________________________________________|____________| Mesentery | + + + | 8 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 4 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 11 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X| 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 15 | Pheochromocytoma Complex | X | 1 | Pheochromocytoma Benign | X | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 13 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X | 39 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X X | 7 | C-Cell, Carcinoma | X X | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | Bilateral, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 8 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 2 | Polyp Stromal | X X X X| 7 | Polyp Stromal, Multiple | X | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | Polyp | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 13 | |__________________________________________________________________________|____________| Lymph Node | + + | 6 | Pancreatic, Leukemia Mononuclear | X | 4 | Renal, Leukemia Mononuclear | X X | 2 | Renal, Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + M + M + + + + + + M + M + + + + +| 36 | Leukemia Mononuclear | X X X X| 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M + + M + + + + + + + + + + + + + + M + +| 44 | Leukemia Mononuclear | X X X X X X| 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + M M + M + + + + + M + +| 42 | Leukemia Mononuclear | X X X X X X| 12 | Plasma Cell Tumor Malignant | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 18 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Leukemia Mononuclear | X X X| 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 2 | Fibroadenoma | X X X X X X X X X X X | 16 | Fibroadenoma, Multiple | X X | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | Subcutaneous Tissue, Hemangioma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | Subcutaneous Tissue, Pinna, Melanoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 2 | Carcinoma, Metastatic, Mammary Gland | | 1 | Leukemia Mononuclear | X X X X X X X| 18 | Plasma Cell Tumor Malignant, | | | Metastatic, Lymph Node, | | | Mediastinal | X | 1 | Mediastinum, Plasma Cell Tumor | | | Malignant, Metastatic, Lymph | | | Node, Mediastinal | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Eye | +| 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 17 | Renal Tubule, Carcinoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 18 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + I I + + I + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Mesentery | + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Leukemia Mononuclear | X | Polyp Stromal | X X X | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Lymph Node | + + | Leukemia Mononuclear | X X | Iliac, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Bronchial | + M + + M + + + + + M M M M + + M + + M M M M + M| Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + M +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + + + + M M +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Sarcoma | X X | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Fibrosarcoma, Metastatic, Skin | X | Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Ear | + | |__________________________________________________________________________| Eye | + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Stromal Nephroma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X X X X | 16 | |__________________________________________________________________________|____________| Mesentery | + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X | 13 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 13 | Pheochromocytoma Benign | X X| 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Leukemia Mononuclear | X X X | 10 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| 33 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X | 6 | C-Cell, Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 7 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Polyp Stromal | X X X X X X | 9 | |__________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 9 | |__________________________________________________________________________|____________| Lymph Node | + | 3 | Leukemia Mononuclear | | 2 | Iliac, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + M + M + M M M + + M + + M + +| 31 | Leukemia Mononuclear | X X X | 11 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 46 | Leukemia Mononuclear | X X X X | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + M + + + +| 45 | Leukemia Mononuclear | X X X X X | 16 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 16 | |__________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + M + + M + + + + + + +| 47 | Leukemia Mononuclear | X | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 2 | Fibroadenoma | X X X X X | 14 | Fibroadenoma, Multiple | X X X | 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Sarcoma | | 2 | Subcutaneous Tissue, Schwannoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Fibrosarcoma, Metastatic, Skin | | 1 | Leukemia Mononuclear | X X X X X | 16 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 13 | Stromal Nephroma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + I + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A A +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A A +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + M A +| Leiomyosarcoma | X | Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | |__________________________________________________________________________| Mesentery | + + + + + + + + | Leukemia Mononuclear | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +| Adenoma | X | Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Adenoma | X X X X X | Carcinoma | X X X| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X X | Polyp Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node | + | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Bronchial | M + + + M + + + + + + + + + + + + + M M + M + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + M M + + + + M M| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X X X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + M + + + + M + + + + + + + + M + + + + M| __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Melanoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + +| |__________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | | Transitional Epithelium, Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leiomyosarcoma | | 1 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 22 | |__________________________________________________________________________|____________| Mesentery | + + + + | 12 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X| 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X X| 13 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X| 13 | Pheochromocytoma Benign | X X X X X X | 9 | Bilateral, Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 7 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| 37 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Carcinoma | X X| 6 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + M + + +| 47 | Adenoma | X | 6 | Carcinoma | X X | 5 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 7 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X X | 7 | Polyp Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X| 10 | |__________________________________________________________________________|____________| Lymph Node | + +| 3 | Iliac, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X| 2 | Renal, Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M M M M + + + + M + + M M + + M + + + +| 36 | Leukemia Mononuclear | X X X X X X X X| 15 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + M + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X| 19 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X| 19 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + M + M M + + + + + + + + + M + + +| 39 | Leukemia Mononuclear | X X X X X X X X| 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X| 22 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 45 | Leukemia Mononuclear | X X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X X | 4 | Fibroadenoma | X X X X X X X X X X X X X | 24 | Fibroadenoma, Multiple | | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Melanoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | X | 2 | Leukemia Mononuclear | X X X X X X X X X X| 20 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + | 6 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X| 16 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 22 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5| DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8| | 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A A +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Mesentery | + + + | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Tongue | | __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5| DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8| | 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Leukemia Mononuclear | X X X | __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5| DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8| | 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Polyp Stromal | X X | Polyp Stromal, Multiple | X| |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Lymph Node | + | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | | Pancreatic, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | M + M M + + M + + + M M + M M + + + M + M M M M +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + M + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Thymus | + + + + + M + + + + M + + + + + + + + + + + + M +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5| DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8| | 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + | |__________________________________________________________________________| Lacrimal Gland | | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5| DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8| | 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lipoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| | | 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + I + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X| 16 | |__________________________________________________________________________|____________| Mesentery | + + + + | 7 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X | 3 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| | | 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X| 13 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X| 13 | Pheochromocytoma Benign | X | 4 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X | 9 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| 36 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | C-Cell, Adenoma | X | 5 | C-Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| | | 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Malignant | X | 1 | Leukemia Mononuclear | X X X X X X | 9 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Polyp Stromal | X X | 4 | Polyp Stromal, Multiple | | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X | 12 | |__________________________________________________________________________|____________| Lymph Node | + | 2 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | X | 1 | Pancreatic, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M + + M + + + + M + + + + M M + + M M + M + M +| 27 | Leukemia Mononuclear | X X X X X X X| 9 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X X X| 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X| 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| | | 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + M + + + + + + + +| 45 | Leukemia Mononuclear | X X X X X X X X| 13 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X| 16 | |__________________________________________________________________________|____________| Thymus | M + + M + M + M + + + M + + + + + + A + + + + + +| 41 | Leukemia Mononuclear | X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 4 | Fibroadenoma | X X X X X X X X X X X| 22 | Fibroadenoma, Multiple | X X X X | 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 5| 7| 4| 6| 6| 6| 0| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 5| 3| 3| 1| 3| 6| 8| 9| 7| 0| 3| 3| 2| 9| 1| 3| 3| 3| 5| 3| 3| | | 0| 4| 2| 4| 9| 4| 4| 2| 4| 9| 1| 2| 1| 5| 4| 5| 0| 2| 1| 5| 5| 5| 7| 5| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X| 16 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + | 4 | |__________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X| 13 | Lipoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X| 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6| DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8| | 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + I + A + + + + + + I + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Adenomatous | | |__________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + A + + A + + + + + + + + + + + + + + + A + +| Carcinoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + A + + A + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X| Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6| DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8| | 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + A + +| C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6| DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8| | 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node | + + + | Histiocytic Sarcoma | | Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | | Iliac, Osteosarcoma, Metastatic, Bone| X | Pancreatic, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | + M + M M + M M M + + M + + + + + M + M + + M + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Lymph Node, Mandibular | + + M + + M + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6| DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8| | 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + M + + M + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + M + M + + + M + M + + M + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + M + M + + M M M + + + + + + + + + + M + + + M +| Carcinoma, Multiple | | Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Lipoma | X | Subcutaneous Tissue, Sarcoma | X | Subcutaneous Tissue, Schwannoma | | Benign | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 7| 5| 6| 6| 4| 4| 3| 7| 7| 7| 6| 6| 5| 6| 6| 7| 7| 6| 7| 5| 5| 4| 6| DAY ON TEST | 4| 6| 3| 4| 3| 3| 6| 7| 7| 3| 3| 3| 5| 6| 5| 9| 3| 1| 2| 2| 0| 8| 7| 7| 8| | 5| 0| 3| 4| 3| 9| 7| 7| 9| 3| 3| 3| 0| 6| 2| 1| 6| 9| 0| 8| 6| 0| 4| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Astrocytoma Malignant | X | Leukemia Mononuclear | X | Oligodendroglioma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X| Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Stromal Nephroma | | Renal Tubule, Adenoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X| Mesothelioma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| | DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| | | 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 1 | Polyp Adenomatous | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X| 21 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + | 15 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| | DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| | | 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tongue | | 1 | |__________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X| 13 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 13 | Pheochromocytoma Benign | X X X X X X X| 13 | Bilateral, Pheochromocytoma Benign | X X X X X X X | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 4 | Carcinoma | X X | 4 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| | DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| | | 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X| 12 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X X X | 43 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | X X X | 5 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 3 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 4 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X | 13 | Interstitial Cell, Adenoma | X X X X X X X| 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| | DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| | | 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X| 14 | |__________________________________________________________________________|____________| Lymph Node | + | 4 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X | 1 | Iliac, Leukemia Mononuclear | X | 1 | Iliac, Osteosarcoma, Metastatic, Bone| | 1 | Pancreatic, Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + M + M + + + + + + M M M + M M + M + + + M M + +| 30 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X| 13 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X X X X X| 16 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X| 17 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | X X X X X X X X X X X| 17 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X| 21 | |__________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + M + M M + + + + + + M + +| 40 | Leukemia Mononuclear | X X X X X | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + M + + + + + + + + + M + + + + + + + + +| 41 | Carcinoma, Multiple | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| | DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| | | 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X X | 3 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Lipoma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Benign | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | Leukemia Mononuclear | X X | 3 | Oligodendroglioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X| 19 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 5| 5| 5| 6| 6| 7| 7| 5| 7| 4| 5| 5| 6| 7| 6| 6| 5| 6| 6| 6| | DAY ON TEST | 1| 3| 3| 7| 7| 1| 3| 9| 8| 8| 3| 0| 7| 1| 9| 3| 8| 2| 0| 8| 9| 4| 6| 4| 1| | | 6| 3| 3| 0| 8| 6| 9| 0| 1| 4| 3| 6| 6| 9| 5| 9| 0| 1| 5| 3| 2| 0| 1| 8| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 15 | Stromal Nephroma | X | 1 | Renal Tubule, Adenoma | X | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X| 21 | Mesothelioma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5| DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3| | 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + | Liposarcoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5| DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3| | 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Leukemia Mononuclear | X | |__________________________________________________________________________| Tooth | +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X| Bilateral, Pheochromocytoma Benign | X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5| DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3| | 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | Bilateral, Carcinoma | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| |__________________________________________________________________________| Lymph Node | + + + + + +| Pancreatic, Leukemia Mononuclear | X X X X X| Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | + + + + M + + + + M M + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5| DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3| | 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | M + + + M + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + M M + + M + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + M + + M + + + + + +| Carcinoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Keratoacanthoma | X X | Squamous Cell Papilloma | X | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Schwannoma | | Malignant | | Subcutaneous Tissue, Pinna, Melanoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 5| 5| 6| 5| 6| 6| 7| 6| 5| 5| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 5| 5| 6| 5| DAY ON TEST | 6| 7| 6| 4| 4| 6| 9| 3| 2| 2| 2| 6| 7| 7| 7| 7| 2| 8| 3| 1| 2| 9| 5| 8| 3| | 4| 9| 0| 2| 7| 2| 2| 3| 4| 6| 6| 0| 1| 1| 0| 8| 7| 3| 2| 4| 3| 2| 2| 4| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X X X X X| Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| Renal Tubule, Adenoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Mesothelioma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| | DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| | | 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | A + + + + + + A + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + A + + + + + + + + + + + + + + A + +| 47 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A + + + + + A A + + + + + + + + + + + + + + A + +| 46 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + A A + + + + + + + + + + + + + + A + +| 46 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 19 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + | 10 | Liposarcoma | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X X X X| 7 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| | DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| | | 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Tooth | + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X| 17 | |__________________________________________________________________________|____________| Adrenal Medulla | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X| 17 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X X | 7 | Bilateral, Pheochromocytoma Benign | X X X X X X | 11 | |__________________________________________________________________________|____________| Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | | 2 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pituitary Gland | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| | DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| | | 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X| 14 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| 40 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + A A + + + + + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | X X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 2 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Carcinoma | | 2 | Bilateral, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Prostate | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Seminal Vesicle | A + + + + + A A + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | 14 | Interstitial Cell, Adenoma | X X X X X | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| | DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| | | 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone Marrow | A + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X X X| 18 | |__________________________________________________________________________|____________| Lymph Node | + + + + +| 11 | Pancreatic, Leukemia Mononuclear | X X X X| 9 | Renal, Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + + M + + + + M + + + M M + + + + M + +| 41 | Leukemia Mononuclear | X X X X X X X X X| 17 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X X X X X X X X| 16 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 19 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | A + + + + + A + + + M + + + + + M + + + M + + + +| 42 | Leukemia Mononuclear | X X X X X X X X| 17 | |__________________________________________________________________________|____________| Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X| 21 | |__________________________________________________________________________|____________| Thymus | A + + + + + A + + + + + + + M + + M + + + + + M +| 42 | Leukemia Mononuclear | X X X X| 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M + + + + + + M + + + + M M + + + M + + + + M M +| 41 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| | DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| | | 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Basal Cell Carcinoma | X X | 2 | Keratoacanthoma | X X | 4 | Squamous Cell Papilloma | | 1 | Sebaceous Gland, Adenoma | X X | 2 | Subcutaneous Tissue, Schwannoma | | | Malignant | X | 1 | Subcutaneous Tissue, Pinna, Melanoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 6 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | X X | 2 | Leukemia Mononuclear | X X X X X X X X X| 19 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 1 | |__________________________________________________________________________|____________| Nose | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 3| 6| 7| 6| 6| 6| 6| 4| 7| 6| 5| 7| 4| 6| 7| 6| 5| 2| 6| 7| 4| 7| 5| 7| 5| | DAY ON TEST | 8| 0| 3| 0| 6| 8| 4| 8| 0| 8| 8| 3| 6| 2| 0| 2| 2| 4| 9| 3| 6| 3| 0| 1| 1| | | 9| 4| 3| 7| 4| 4| 1| 2| 2| 4| 3| 3| 9| 6| 6| 5| 7| 4| 2| 3| 0| 3| 7| 6| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Zymbal's Gland | + + | 2 | Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 18 | Renal Tubule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 21 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5| DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8| | 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +| Carcinoma | | Hemangiosarcoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Mesentery | + + + | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5| DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8| | 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X X X X X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5| DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8| | 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Leukemia Mononuclear | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X | Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Lymph Node | + + + | Histiocytic Sarcoma | | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | | Pancreatic, Histiocytic Sarcoma | | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | M M + + + + M + M + M + + + + + + + + + M + M M M| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5| DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8| | 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + + M + + + + + + M + + + + M + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Thymus | M + + + + M + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + M M + + + + + + + + + M + + + + + + + + + + +| Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Squamous Cell Papilloma | | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Histiocytic | | Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5| DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8| | 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | Leukemia Mononuclear | | |__________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X| Renal Tubule, Carcinoma | X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________|__________________________________________________________________________ | 4| 5| 6| 5| 6| 6| 5| 5| 5| 7| 5| 5| 6| 7| 7| 5| 6| 5| 7| 7| 5| 6| 3| 7| 5| DAY ON TEST | 9| 6| 2| 8| 1| 5| 5| 7| 1| 0| 1| 7| 7| 1| 0| 5| 7| 9| 0| 3| 2| 5| 5| 0| 8| | 7| 5| 0| 5| 4| 0| 8| 4| 2| 6| 6| 9| 8| 4| 6| 1| 1| 0| 1| 3| 0| 4| 2| 5| 0| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X| __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| | DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| | | 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 | Carcinoma | X | 1 | Hemangiosarcoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 2 | Leukemia Mononuclear | X X X X X X X X X X X X X| 20 | |__________________________________________________________________________|____________| Mesentery | + + + + + | 8 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 4 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| | DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| | | 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 14 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X X X | 8 | Bilateral, Pheochromocytoma Benign | X X X | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 11 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| | DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| | | 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| 40 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 | C-Cell, Adenoma | X X | 5 | C-Cell, Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 2 | Carcinoma | X | 2 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | 17 | Interstitial Cell, Adenoma | X X X X X| 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| | DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| | | 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Histiocytic Sarcoma | X X | 2 | Leukemia Mononuclear | X X X X X X X X X X| 16 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + | 10 | Histiocytic Sarcoma | X | 1 | Iliac, Leukemia Mononuclear | | 1 | Inguinal, Leukemia Mononuclear | X | 1 | Pancreatic, Histiocytic Sarcoma | X | 1 | Pancreatic, Leukemia Mononuclear | X X X X | 6 | Renal, Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M + + M + + + + M + + M + M + + + + + + +| 35 | Histiocytic Sarcoma | X X | 2 | Leukemia Mononuclear | X X X X X X X X X| 13 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X| 18 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X X| 19 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + M| 44 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 18 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X| 20 | |__________________________________________________________________________|____________| Thymus | + + M M + + M + M + + M M + + + M + M + M + + + +| 38 | Leukemia Mononuclear | X X X X| 8 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| | DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| | | 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M + + + + + + + + M M + + M M + + I + + M + + + +| 40 | Fibroadenoma | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 2 | Squamous Cell Papilloma | X X | 2 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | | 2 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X| 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Histiocytic Sarcoma | X X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 4| 4| 7| 6| 5| 7| 7| 6| 7| 4| 7| 5| 6| 5| | DAY ON TEST | 0| 3| 5| 8| 0| 3| 1| 5| 1| 2| 2| 9| 8| 3| 2| 5| 1| 3| 2| 0| 5| 3| 8| 5| 6| | | 0| 3| 2| 0| 7| 3| 4| 2| 4| 8| 0| 6| 0| 3| 8| 5| 4| 3| 7| 0| 3| 3| 3| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X X X X| 20 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 4 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X| 19 | Renal Tubule, Carcinoma | | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 2 | Leukemia Mononuclear | X X X X X X X X X X X X X| 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7| DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3| | 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| Leiomyosarcoma | | Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Tongue | | Hemangiosarcoma | | __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7| DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3| | 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X X X| Bilateral, Pheochromocytoma Malignant| | Bilateral, Pheochromocytoma Benign | X X X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X | |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X X X X X X | __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7| DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3| | 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | Leukemia Mononuclear | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Lymph Node | + + + + + + | Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X X X | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7| DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3| | 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + M + + + M + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X X X X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + M + M + + + M| Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + + + + + + + + + + M + + + + + + M + + M + + +| Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X | Squamous Cell Papilloma | | Subcutaneous Tissue, Rhabdomyosarcoma| | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 6| 7| 6| 5| 6| 6| 5| 5| 6| 6| 5| 7| 7| 6| 7| DAY ON TEST | 4| 6| 3| 8| 6| 5| 3| 3| 1| 6| 7| 0| 8| 3| 6| 4| 7| 8| 0| 8| 2| 3| 3| 8| 3| | 8| 4| 4| 8| 4| 0| 3| 3| 1| 7| 0| 1| 8| 4| 6| 7| 6| 3| 4| 8| 5| 3| 3| 9| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| Stromal Nephroma | X | Renal Tubule, Adenoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| | DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| | | 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leiomyosarcoma | X | 1 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 30 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + +| 11 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| | DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| | | 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Tongue | + | 1 | Hemangiosarcoma | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | +| 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 20 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 20 | Pheochromocytoma Malignant | X | 2 | Pheochromocytoma Benign | X X X | 11 | Bilateral, Pheochromocytoma Malignant| X | 1 | Bilateral, Pheochromocytoma Benign | X X X X X| 12 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 4 | Carcinoma | X| 4 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| | DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| | | 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X | 14 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X X| 41 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X | 7 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Carcinoma | X X X| 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X| 1 | Carcinoma | X | 3 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X | 14 | Interstitial Cell, Adenoma | X X X| 11 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| | DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| | | 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 23 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 10 | Leukemia Mononuclear | X | 1 | Iliac, Leukemia Mononuclear | X X | 3 | Pancreatic, Leukemia Mononuclear | X X | 6 | Renal, Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M M + + M + + + + + + + + M + + + + + + + + + + +| 45 | Leukemia Mononuclear | X X X X X X X X X X X X X | 28 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X X | 27 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 27 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + + M + + + +| 45 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 26 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 31 | |__________________________________________________________________________|____________| Thymus | M + + M + + + + + + + + + + + + + + M M + + + + +| 42 | Leukemia Mononuclear | X X X X X X X | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + + + + + + + + M + + + + + + +| 44 | Fibroadenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| | DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| | | 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X | 2 | Keratoacanthoma | X X X| 4 | Squamous Cell Papilloma | X | 1 | Subcutaneous Tissue, Rhabdomyosarcoma| X| 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | +| 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 30 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 NTP Experiment-Test: 88070-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:40:24 __________________________________________________________________________________________________________________________________ | 5| 5| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 6| 4| 7| 7| 6| 7| 6| 5| 6| 6| 6| 6| 7| | DAY ON TEST | 6| 4| 0| 7| 6| 1| 5| 3| 3| 3| 9| 0| 3| 9| 3| 0| 1| 2| 5| 0| 0| 9| 0| 3| 0| | | 0| 0| 8| 8| 4| 0| 8| 3| 3| 1| 0| 1| 6| 0| 3| 2| 8| 0| 0| 5| 7| 2| 4| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 26 | Stromal Nephroma | | 1 | Renal Tubule, Adenoma | X | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 8 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 31 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------