TDMS Study 88070-03 Pathology Tables
NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 CORE STUDY Facility: Battelle Northwest Chemical CAS #: 115-11-0007 Lock Date: 10/05/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 4 | Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X | Degeneration, Fatty | 3 2 3 2 1 3 2 | Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X | Inflammation, Granulomatous | | Mixed Cell Focus | X X X X | Necrosis | 2 2 | Regeneration | | Thrombosis | 2 | Bile Duct, Hyperplasia | 2 2 2 2 | Centrilobular, Necrosis | 2 1 1 | __________________________________________________________________________| Mesentery | + + + + + | Fat, Hemorrhage | 1 | Fat, Necrosis | 2 2 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 2 1 1 | Basophilic Focus | X | Metaplasia, Hepatocyte | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 2 | Mineralization | | Necrosis | 4 3 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 2 1 1 1 1 1 2 1 2 2 2 1 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | | Hyperplasia | 2 2 2 2 1 | Hypertrophy | 2 2 1 1 2 3 | Necrosis | 2 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 3 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 2 1 1 2 1 1 2 3 2 2 1 1 1 2 3 2 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 2 2 3 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | __________________________________________________________________________| Lymph Node | + + + + | __________________________________________________________________________| Lymph Node, Bronchial | + M + + M + + + + M + M + + + M M + + M + M + M +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + M + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + M + + + + + M + + + + + + + M + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3 4 | Hemorrhage | 2 | Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 6| 6| 7| 4| 4| 4| 7| 7| 5| 5| 5| 7| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 3| 3| 3| 2| 7| 1| 6| 4| 3| 8| 9| 4| 3| 3| 8| 5| 2| 3| 0| 3| 3| 2| 3| 8| 3| | 3| 3| 3| 0| 3| 4| 3| 2| 3| 8| 6| 0| 3| 4| 1| 2| 9| 4| 5| 4| 4| 1| 4| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 1 2 2 2 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 1 2 | Alveolar Epithelium, Hyperplasia | 1 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 1 1 2 | Thrombosis | 3 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 2 1 1 2 2 1 1 1 2 2 2 1 2 2 1 1 1 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Cataract | 2 3 3 | Retina, Atrophy | 3 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 | Nephropathy | 3 2 2 1 1 2 1 1 3 1 2 1 2 1 2 3 2 2 1 3 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A A + + + + + + + + + + + + + + + + + + + I +| 47 | Parasite Metazoan | X X X | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A A + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Acute | | 1 4.0| Parasite Metazoan | X | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + A + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X | 36 | Clear Cell Focus | X X X X | 6 | Degeneration, Fatty | 3 2 2 2 2| 12 2.3| Eosinophilic Focus | X X X X | 6 | Hepatodiaphragmatic Nodule | X X X | 4 | Inflammation, Granulomatous | 1 | 1 1.0| Mixed Cell Focus | X X X | 7 | Necrosis | | 2 2.0| Regeneration | 4 | 1 4.0| Thrombosis | | 1 2.0| Bile Duct, Hyperplasia | 2 2 2 2 1| 9 1.9| Centrilobular, Necrosis | 2 | 4 1.5| __________________________________________________________________________|____________| Mesentery | + + + | 8 | Fat, Hemorrhage | | 1 1.0| Fat, Necrosis | 2 2 2 | 8 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 2 | 9 1.7| Basophilic Focus | | 1 | Metaplasia, Hepatocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | | 1 2.0| Mineralization | 1 | 1 1.0| Necrosis | 2 1 3| 7 2.7| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 | 3 1.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 2 1 1 2 2 2 1 2 2 2 2 1 | 30 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 2 2 | 2 2.0| Hyperplasia | 2 2 1 2 2 2 2 2 2 2 | 15 1.9| Hypertrophy | 1 2 1 2 2 | 11 1.7| Necrosis | | 2 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 3 2 2 | 10 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia | 1 3 2 3| 7 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 2 1 2 3 1 1 1 2 2 1 1 2 2 1 2| 37 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 | 9 2.3| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + | 6 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + M + M + + + + + + M + M + + + + +| 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M + + M + + + + + + + + + + + + + + M + +| 44 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + M M + M + + + + + M + +| 42 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 3 | 5 3.2| Hemorrhage | | 1 2.0| Necrosis | 2| 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 2 | 2 2.5| Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | 3 | 1 3.0| Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 1 2 3 3 | 9 1.9| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Granulomatous | 1 2 1 1 1 | 7 1.3| Alveolar Epithelium, Hyperplasia | 2 1 2 1 1 | 9 1.2| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 1 | 7 1.3| Thrombosis | | 2 2.5| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 1 1 2 1 2 2 2 2 1 2 1 2 2 1 1 2 1 1 1 1 2| 44 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | +| 4 | Cataract | 4| 4 3.0| Retina, Atrophy | 4| 3 3.3| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 7| 5| 7| 6| 7| 7| 6| | DAY ON TEST | 9| 3| 4| 1| 3| 2| 2| 3| 3| 3| 3| 6| 7| 3| 3| 3| 2| 9| 3| 5| 0| 0| 3| 3| 4| | | 1| 4| 2| 5| 4| 2| 6| 4| 4| 4| 4| 4| 8| 5| 5| 5| 0| 0| 5| 2| 5| 8| 5| 5| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | | 1 2.0| Nephropathy | 1 1 2 2 3 3 2 3 2 2 2 1 1 3 2 1 2 1 2 2 2 2 2 2 2| 46 1.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + I I + + I + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +| Inflammation, Acute | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +| Inflammation, Acute | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X X | Degeneration, Fatty | 2 2 1 3 2 2 | Eosinophilic Focus | X X X | Hepatodiaphragmatic Nodule | X X X X X X| Mitotic Alteration | | Mixed Cell Focus | X X X X | Regeneration | 3 | Bile Duct, Hyperplasia | 1 3 2 | Centrilobular, Necrosis | 3 2 2 2 | __________________________________________________________________________| Mesentery | + + + + + + + | Fat, Necrosis | 2 3 3 3 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 1 | Basophilic Focus | X X | Hyperplasia | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Basal Cell | 2| Necrosis | 2 4 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 2 2 1 1 1 1 1 2 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Degeneration, Cystic | 2 | Hyperplasia | 3 2 1 2 2 1 | Hypertrophy | 1 2 1 | Thrombosis | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | 3 4 3 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 3 2 2 2 2 3 2 2 2 2 1 2 2 1| Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 4 1 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cervix, Hypertrophy | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1| __________________________________________________________________________| Lymph Node | + + | Pancreatic, Ectasia | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + M + + + + + M M M M + + M + + M M M M + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + M +| Infiltration Cellular, Plasma Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + + + + M M +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Spleen | X | Fibrosis | 1 2 | Hematopoietic Cell Proliferation | 2 | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 4| 5| 7| 7| 0| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 6| 4| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 9| 4| 2| 0| 1| 3| 3| 1| 6| 3| 4| 3| 0| 3| 3| 6| 0| 9| 8| 3| 9| 8| 6| 3| 3| | 6| 8| 2| 8| 3| 3| 3| 9| 2| 3| 0| 3| 8| 4| 4| 5| 3| 4| 8| 4| 2| 8| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 1 3 1 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 1 | Inflammation, Suppurative | 3 | Alveolar Epithelium, Hyperplasia | 1 1 2 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Thrombosis | 3 1 4 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 3 3 3 2 3 3 3 2 2 3 3 3 3 2 2 2 3 3 2 3 2 2 2| Respiratory Epithelium, Metaplasia, | | Squamous | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + + + | Cataract | 3 3 | Retina, Atrophy | 3 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 2 1 2 1 2 1 2 2 1 3 2 1 2 2 2 1 1 2 3 2 2| Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X X X X| 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Inflammation, Acute | 4 | 1 4.0| Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | Inflammation, Acute | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | Inflammation, Acute | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 2 1 | 3 1.3| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 36 | Clear Cell Focus | X X X| 9 | Degeneration, Fatty | 3 1 2 3 | 10 2.1| Eosinophilic Focus | X X X| 6 | Hepatodiaphragmatic Nodule | X | 7 | Mitotic Alteration | 4 | 1 4.0| Mixed Cell Focus | X X X X X X X| 11 | Regeneration | | 1 3.0| Bile Duct, Hyperplasia | 2 1 | 5 1.8| Centrilobular, Necrosis | | 4 2.3| __________________________________________________________________________|____________| Mesentery | + + + | 10 | Fat, Necrosis | 2 2 2 | 10 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 2 2 2 2 1| 11 1.7| Basophilic Focus | X X | 4 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Basal Cell | | 1 2.0| Necrosis | 2 1 4 | 7 2.6| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 3 | 2 2.5| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 2 1 1 1 1 2 1 1 2 1 1 2 1 2 1 | 29 1.4| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 4 | 1 4.0| Degeneration, Cystic | 2 | 2 2.0| Hyperplasia | 2 2 2 2 2 2 2 2 2 2| 17 1.9| Hypertrophy | 2 2 2 2 2| 8 1.8| Thrombosis | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 5 2.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Pars Distalis, Angiectasis | 3 | 1 3.0| Pars Distalis, Hyperplasia | 3 2 2 | 7 2.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 2 2 1 2 1 2 3 1 1 1 1 1 1 1 2 1| 34 1.6| Follicular Cell, Hyperplasia | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 | 4 2.8| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cervix, Hypertrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 1.0| __________________________________________________________________________|____________| Lymph Node | + | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + M + M + M M M + + M + + M + +| 31 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| 46 | Infiltration Cellular, Plasma Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + M + + + +| 45 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Spleen | | 1 | Fibrosis | 2 | 3 1.7| Hematopoietic Cell Proliferation | 4 | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + M + + M + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 3 2 | 2 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 3 3 2 | 7 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Granulomatous | 1 1 1 1| 5 1.0| Inflammation, Suppurative | | 1 3.0| Alveolar Epithelium, Hyperplasia | 2 3 1 1 1| 9 1.4| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 2 1.5| Thrombosis | | 3 2.7| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 2 2 2 2 2 1 2 2 3 3 3 2 2 2 3 2 2 3 2 3 3| 47 2.4| Respiratory Epithelium, Metaplasia, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 5| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 6| 2| 7| 7| 4| 4| 7| 4| 7| 7| | DAY ON TEST | 3| 1| 3| 8| 3| 3| 1| 7| 3| 3| 3| 0| 1| 3| 2| 3| 1| 3| 3| 2| 7| 3| 5| 3| 3| | | 4| 6| 4| 0| 4| 4| 8| 3| 4| 0| 4| 1| 4| 4| 1| 5| 6| 4| 5| 0| 9| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Squamous | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | + | 4 | Cataract | 4 | 3 3.3| Retina, Atrophy | 4 | 3 3.3| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 1 2 2 2 3 2 2 1 2 2 1 2 2 2 2 1 1 2 1 2 2 1 2 2| 46 1.7| Renal Tubule, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + I + + + + +| Parasite Metazoan | X X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A A +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + M A +| Necrosis | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 1 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Degeneration, Cystic | | Degeneration, Fatty | 2 3 3 3 1 | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | 1 | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X 3 X X| Necrosis | 2 | Regeneration | 2 3 | Bile Duct, Hyperplasia | 1 2 2 | Centrilobular, Necrosis | 1 1 1 | __________________________________________________________________________| Mesentery | + + + + + + + + | Thrombosis | | Fat, Necrosis | 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + A +| Atrophy | 2 1 2 1 1 1 2 1 1 1 | Basophilic Focus | X | Hyperplasia | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 1 3 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Necrosis | | __________________________________________________________________________| Tooth | | Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 2 2 1 1 1 2 2 2 2 2 1 2 2 2 2 2 1 2 1 2| Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + A +| Degeneration, Cystic | 2 2 3 | Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 | Hypertrophy | 1 2 2 2 3 2 | Necrosis | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + A +| Hyperplasia | 2 1 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Pars Distalis, Hyperplasia | 1 2 2 1 2 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| C-Cell, Hyperplasia | 1 1 2 3 2 1 1 2 1 2 1 2 3 1 2 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Hyperplasia | 2 | Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 3 3 | Inflammation, Granulomatous | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +| Hyperplasia, Reticulum Cell | | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Bronchial | M + + + M + + + + + + + + + + + + + M M + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| Infiltration Cellular, Plasma Cell | 4 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + M + + + M + + + M M + + + + M M| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +| Fibrosis | 2 2 2 | Hematopoietic Cell Proliferation | 2 4 4| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 0| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 0| 3| | 3| 1| 2| 3| 3| 3| 6| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 5| 0| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + M + + + + M + + + + + + + + M + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | Inflammation, Acute | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 2 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia | 1 2 1 1 | Bronchiole, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 1 1 1 | Thrombosis | 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 3 3 3 3 4 2 3 2 3 3 3 3 3 3 2 3 3 2 2 3 2 3 3| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + +| Cataract | 3 4 3 4| Retina, Atrophy | 4 4 4 3| __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +| Nephropathy | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1 2 3 2 2 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 4 1.5| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | 43 | Clear Cell Focus | X X X X X X X X | 12 | Degeneration, Cystic | 4 2 | 2 3.0| Degeneration, Fatty | 3 1 2 2 3 2 2| 12 2.3| Eosinophilic Focus | X X X| 5 | Hematopoietic Cell Proliferation | | 1 1.0| Hepatodiaphragmatic Nodule | X X X | 5 | Mixed Cell Focus | X X X X X | 9 3.0| Necrosis | 1 | 2 1.5| Regeneration | | 2 2.5| Bile Duct, Hyperplasia | 2 1 2 2| 7 1.7| Centrilobular, Necrosis | 1 1 | 5 1.0| __________________________________________________________________________|____________| Mesentery | + + + + | 12 | Thrombosis | 3 | 1 3.0| Fat, Necrosis | 2 2 2 3 | 12 2.1| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 4 2 1 2 2 3| 17 1.6| Basophilic Focus | X X | 3 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 3 1 2 | 6 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tooth | + | 1 | Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy | 2 1 2 2 2 1 2 3 1 2 2 1 2 2 2 2 2 | 37 1.8| Atrium, Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Cystic | 2 | 4 2.3| Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 1 2 | 24 2.0| Hypertrophy | 2 1 2 | 9 1.9| Necrosis | 3 2 | 3 2.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 | 6 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Pars Distalis, Hyperplasia | 3 4 2 4 2 | 11 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 2 1 2 2 2 1 1 1 2 1 1 2 1 1 2 1 3 2 1 1 1 1 | 38 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + M + + +| 47 | Hyperplasia | 3 3 3 3 | 5 2.8| Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 4 2.5| Inflammation, Granulomatous | 1 | 1 1.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia, Reticulum Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + +| 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M M M M + + + + M + + M M + + M + + + +| 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + M + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Plasma Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + + + M + M M + + + + + + + + + M + + +| 39 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 2 1 2 | 6 1.8| Hematopoietic Cell Proliferation | | 3 3.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Galactocele | 2 | 1 2.0| Inflammation, Acute | 4 | 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 3 2 3 3 3| 11 2.4| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Granulomatous | 1 1 1 1| 9 1.0| Alveolar Epithelium, Hyperplasia | 3 1 1 | 7 1.4| Bronchiole, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 2 3 | 8 1.5| Thrombosis | 4 | 2 3.0| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 3 3 3 3 2 3 3 2 2 2 3 3 3 3 3 3 2 3 3 3 3 3 4| 48 2.8| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 9| 4| 3| 3| 3| 8| 6| 2| 3| 5| 5| 3| 3| 3| | | 6| 5| 5| 5| 5| 5| 5| 5| 5| 4| 0| 9| 4| 5| 5| 5| 6| 0| 0| 5| 1| 2| 5| 5| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 6 | Cataract | 3 3 | 6 3.3| Retina, Atrophy | 3 4 | 6 3.7| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Nephropathy | 2 2 2 1 2 2 2 2 2 3 2 2 2 2 2 2 2 1 1 2 2 3 2| 46 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5| DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8| | 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A A +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Basophilic Focus | X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X | Cytomegaly | | Degeneration, Fatty | 2 3 3 3 1 1| Eosinophilic Focus | X X X X X X X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X X X | Regeneration | 4 3 | Bile Duct, Hyperplasia | 2 3 1 1 | Centrilobular, Necrosis | 1 2 4 2 | __________________________________________________________________________| Mesentery | + + + | Artery, Inflammation, Chronic Active | 3 | Fat, Necrosis | 2 2 2 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 1 1 1 1 | Basophilic Focus | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 3 2 2 3 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | __________________________________________________________________________| Tongue | | Hyperplasia, Squamous | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 2 1 1 1 2 1 1 2 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 88070-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC ISOBUTENE Date: 06/11/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:56:43 _____________________________________________________________________________________________________________________ | 6| 7| 6| 7| 6| 7| 7| 5| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 5| DAY ON TEST | 6| 0| 5| 3| 2| 3| 2| 9| 3| 6| 4| 3| 3| 7| 3| 3| 3| 3| 0| 3| 3| 0| 6| 0| 8| | 4| 6| 0| 3| 8| 3| 9| 7| 3| 3| 7| 3| 0| 4| 4| 4| 4| 4| 0| 4| 4| 2| 8| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Degeneration, Cystic | | Hyperplasia | 2 3 2 2 2 2 2 1 3 2 1 | Hypertrophy | 2 2 2 2 | Necrosis | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 4 | Pars Distalis, Cyst | 4| Pars Distalis, Hyperplasia | 2 2 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 2 1 1 1 2 1 1 1 1 1 2 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Necrosis | 4| __________________________________________________________________________| Vagina | + | Inflammation, Suppurative | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hyperplasia, Histiocytic | | __________________________________________________________________________| Lymph Node |