TDMS Study 88070-04 Pathology Tables
NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 Facility: Battelle Northwest Chemical CAS #: 115-11-0007 Lock Date: 10/05/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3| | 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Large, Rectum | I + + + + + + + + A + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + A +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + A +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + A +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + A + + + + + + + + + + + + + A +| Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X X X| Hepatocellular Adenoma, Multiple | X | Hepatocholangiocarcinoma | | Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X | |__________________________________________________________________________| Mesentery | + + + + +| |__________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + A +| Lymphoma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| Lymphoma Malignant | X X X X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3| | 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Lymphoma Malignant | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + I + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + A +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + M + + + + M + + + + + M + + + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Pars Distalis, Adenoma | X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + M M + + + + I I + + I + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3| | 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Ovary | + + + + + + + + + + + + + + + + + + + + + + + A +| Granulosa Cell Tumor Benign | | Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | Teratoma Benign | X | Yolk Sac Carcinoma | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Polyp Stromal | X | Polyp Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +| Hemangiosarcoma | X | |__________________________________________________________________________| Lymph Node | + + + + | Iliac, Histiocytic Sarcoma | | Iliac, Lymphoma Malignant | X X | Lumbar, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | X | Renal, Histiocytic Sarcoma | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + M + + M + + + + + M + M + + M M +| Lymphoma Malignant | X X X X| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + M + + + + + M + + M +| Lymphoma Malignant | X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + I + + + + + + A +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | + M + M + + M + + M + + + + M + + + M M M + + + +| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3| | 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + A +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +| Carcinoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Benign | X | Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3| | 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X X X | Carcinoma, Metastatic, Mammary Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Nose | + + + + + + + + + A + + + + + + + + + + + + + A +| Lymphoma Malignant | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Harderian Gland | | Adenoma | | Bilateral, Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| | | 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + I| 46 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + A + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Hepatocellular Carcinoma | | 4 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X| 15 | Hepatocellular Adenoma, Multiple | X X X X | 5 | Hepatocholangiocarcinoma | X | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X | 5 | |__________________________________________________________________________|____________| Mesentery | + + | 7 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| | | 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Lymphoma Malignant | | 4 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | M + + M M + + M + + M M + M A + + + M M + + + M +| 35 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | Pars Distalis, Adenoma | X X X | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| | | 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Granulosa Cell Tumor Benign | X | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X | 4 | Teratoma Benign | | 1 | Yolk Sac Carcinoma | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | Polyp Stromal | X | 2 | Polyp Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + | 7 | Iliac, Histiocytic Sarcoma | X | 1 | Iliac, Lymphoma Malignant | X | 3 | Lumbar, Lymphoma Malignant | X | 1 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Histiocytic Sarcoma | X | 1 | Renal, Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + + + M + + + M M + + A + + + + + + + + M +| 38 | Lymphoma Malignant | X X X X | 8 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + M + + + M + + + A + + M + + + + + + +| 41 | Lymphoma Malignant | X X X | 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| | | 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X X | 11 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + M M + + + + + A + + + + + M + + + +| 38 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 9 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Hemangiosarcoma | X X | 3 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X X | 13 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Carcinoma | X | 2 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Subcutaneous Tissue, Sarcoma | X X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| | | 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Astrocytoma Benign | | 1 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | X | 4 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X | 7 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + | 2 | Adenoma | X | 1 | Bilateral, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| | | 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X X X | 4 | |__________________________________________________________________________|____________| Urinary Bladder | + I + M + + + + + + + A + + A + + + + + + + + + +| 45 | Lymphoma Malignant | | 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X X X | 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + A + + + M M + + A + + A + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + I + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + A + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + A + + A + + + + + + + + + +| Carcinoma | | Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatoblastoma | X | Hepatoblastoma, Multiple | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Adenoma | X X X X X X X X X X X | Hepatocellular Adenoma, Multiple | X X X X| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X | |__________________________________________________________________________| Mesentery | + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | Capsule, Adenoma | X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant | X | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + M + + M M + + M + M + M + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X X| Granulosa Cell Tumor Benign | X | Hemangioma | X | Histiocytic Sarcoma | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | Polyp Stromal | | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node | | Iliac, Histiocytic Sarcoma | | Renal, Histiocytic Sarcoma | | |__________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + M M + + M + M + + + + + + + M +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + M| Histiocytic Sarcoma | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + + M + + + M + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + M + M + + + + + + + + M + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | X | Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Hepatoblastoma, Metastatic, Liver | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | | Lymphoma Malignant | X X X | Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Pleura | + | Hepatoblastoma, Metastatic, Liver | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Harderian Gland | | Adenoma | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Histiocytic Sarcoma | | Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X X X | __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| | | 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 43 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + I + + I + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Carcinoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatoblastoma | | 1 | Hepatoblastoma, Multiple | | 1 | Hepatocellular Carcinoma | X X X X| 8 | Hepatocellular Adenoma | X X X X X X X| 18 | Hepatocellular Adenoma, Multiple | | 4 | Histiocytic Sarcoma | X X X X | 4 | Lymphoma Malignant | X | 5 | |__________________________________________________________________________|____________| Mesentery | + + + + + | 8 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| | | 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 2 | Capsule, Adenoma | | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + M + + + + + + M + + + M + + + M + + + + + +| 39 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| | | 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + M M + + + + + + + + + + + + + + M + + + + + +| 46 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | X | 3 | Granulosa Cell Tumor Benign | X | 2 | Hemangioma | | 1 | Histiocytic Sarcoma | X X X | 3 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | | 1 | Polyp Stromal | X | 1 | |__________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| | | 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node | + + | 2 | Iliac, Histiocytic Sarcoma | X | 1 | Renal, Histiocytic Sarcoma | X X | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M + + M M + M M + + + + + + + M M + + M M + M M M| 33 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M M + + + + + + + M + + + M + M M + + + + +| 42 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | X X X | 3 | Lymphoma Malignant | X X X | 6 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M + M + + + + + + + + + + + M + + + + + + + +| 42 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant | X X | 7 | |__________________________________________________________________________|____________| Thymus | M + + M + + + + + + + + + + + + + + + + + + M + +| 44 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| | | 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | Subcutaneous Tissue, Sarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | X X | 2 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Hepatoblastoma, Metastatic, Liver | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X| 4 | Histiocytic Sarcoma | X X X X | 4 | Lymphoma Malignant | | 3 | Sarcoma, Metastatic, Skin | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| | | 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Pleura | | 1 | Hepatoblastoma, Metastatic, Liver | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + | 2 | Adenoma | X | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X X | 3 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X X X | 4 | Lymphoma Malignant | X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3| | 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + A + + + + + M + + + + + + + M + M +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | X X X X | Lymphoma Malignant | X X X X | |__________________________________________________________________________| Mesentery | + + | Lipoma | | Lymphoma Malignant | | |__________________________________________________________________________| Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3| | 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | X | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + M + M + A + + + + + + M + + + + + + M + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Pars Distalis, Adenoma | X X X X X X X | Pars Distalis, Carcinoma | X | Pars Intermedia, Adenoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3| | 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + A + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + A + + + + + + + + + + + + + + + + +| Cystadenoma | X | Hemangioma | X | Hemangiosarcoma | | Histiocytic Sarcoma | | Luteoma | | Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + | Lymphoma Malignant | | Iliac, Lymphoma Malignant | X | Inguinal, Hemangiosarcoma | | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Bronchial | M + + M + M + + + + + + + + + + M + + + + M M + +| __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3| | 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M A M + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + A + + + + M + + + + + + + I + + + +| Lymphoma Malignant | X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | M + M + M + + M + + + + + + M + + + + + + + M + +| Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + A + + + + M + + + + + + + + + + + +| Lymphoma Malignant | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3| | 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X X X X | |__________________________________________________________________________| Nose | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| | | 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + A + + + + + + + + + + A + + + A +| 43 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | I + + + + I + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + A + + + A +| 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + A + + + A +| 46 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + A + + + A +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X | 6 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X | 11 | Hepatocellular Adenoma, Multiple | X X X X | 8 | Lymphoma Malignant | X X X | 7 | |__________________________________________________________________________|____________| Mesentery | + + + + + + | 8 | Lipoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| | | 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 | Lymphoma Malignant | X | 1 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Benign | X X | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Adenoma | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| | | 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Parathyroid Gland | + + M + + M + + + + M + + + + M M + + M + + + M +| 37 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Lymphoma Malignant | | 1 | Pars Distalis, Adenoma | X X X X X | 12 | Pars Distalis, Carcinoma | | 1 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | | 3 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + M M + + + + + + + + + A + + + + +| 45 | |__________________________________________________________________________|____________| Ovary | + + + + + I + + + + + + + + + + + + + + + + + + +| 48 | Cystadenoma | | 1 | Hemangioma | | 1 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 1 | Luteoma | X | 1 | Lymphoma Malignant | X X | 7 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | Polyp Stromal | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| | | 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 5 | Lymphoma Malignant | X | 1 | Iliac, Lymphoma Malignant | X | 2 | Inguinal, Hemangiosarcoma | X | 1 | Pancreatic, Lymphoma Malignant | X | 2 | Renal, Lymphoma Malignant | X X X | 4 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | Lymphoma Malignant | X X X X X | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + M + + M + + + + + + + + +| 44 | Lymphoma Malignant | X X X | 8 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant | X X X X X | 8 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + M M M + + M + + + + + + + M + + M + + + M| 36 | Lymphoma Malignant | X X X | 8 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X X X | 16 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Carcinoma | X X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| | | 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Lymphoma Malignant | X X | 6 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| | DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| | | 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Harderian Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X X | 5 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X X X X X X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| | 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A + M + + + + + + + + + + + + + M + A + + + M + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + A + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X | Lymphoma Malignant | X X X X | |__________________________________________________________________________| Mesentery | + + + + + + | |__________________________________________________________________________| Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| | 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + I + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Malignant| X | |__________________________________________________________________________| Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Pars Distalis, Adenoma | X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Follicular Cell, Adenoma | X | Follicular Cell, Adenoma, Multiple | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| | 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + M M + + + + + + M M + + + + + + + + + M + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X X| Granulosa-Theca Tumor Benign | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node | + + + | Lymphoma Malignant | X | Iliac, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X X X | |__________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + M + + + + +| Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + M M + + M + + + + + + + M + + + +| Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + M + + M + + + + + + + M M + + + + + + + + + M| Lymphoma Malignant | X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X X X X X X X | __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| | 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + M +| Lymphoma Malignant | X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| | 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + M + + + + + + + + + + A + + + + + + + +| 43 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + I + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant | X X | 4 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X X| 9 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X X X X X X X | 13 | Hepatocellular Adenoma, Multiple | X X X X | 7 | Lymphoma Malignant | X X X X | 8 | |__________________________________________________________________________|____________| Mesentery | + + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X X X | 5 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Benign | X| 2 | Bilateral, Pheochromocytoma Malignant| | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + M + + M + + M + + M + M + M + + + +| 41 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X X X X X | 12 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Adenoma, Multiple | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | | 2 | Granulosa-Theca Tumor Benign | X | 1 | Lymphoma Malignant | X X | 5 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node | + | 4 | Lymphoma Malignant | | 1 | Iliac, Lymphoma Malignant | X | 2 | Pancreatic, Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + + M + + + M + + M + + + + + + + +| 44 | Lymphoma Malignant | X X X X | 9 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + M + + M + + + + + + + M + + + + + + M M + M| 38 | Lymphoma Malignant | X X X | 8 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X X X X X | 10 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + M + + + + + M +| 42 | Lymphoma Malignant | X X X X | 9 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Lymphoma Malignant | X X X X X X X X X| 16 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + + + + + + M + + + +| 46 | Lymphoma Malignant | X X X | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant | | 1 | Subcutaneous Tissue, Sarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X X X | 6 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | X | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| | | 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X| 4 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X X X X X X X X X| 19 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + A + + + + + + + + M + +| |__________________________________________________________________________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + A + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + A + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + | Odontoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Capsule, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + I +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + | Iliac, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | X | Renal, Histiocytic Sarcoma | | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Bronchial | + + + + M M M + + M M M + M M + + + + + M M + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | M + + M + + + M + + + + + + M + M M + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + A + + + + + + + + + + + + + M + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + M M + M + + M + M + + M + + + + + M + M M + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + + M + M + + + + + M M M| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + I + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + | |__________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | Carcinoma | | Bilateral, Adenoma | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3| | 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Renal Tubule, Adenoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| | DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| | | 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + A + + + + + + + + M + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + A + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + A + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + A + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + A + + +| 46 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + A + + A + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + A + + +| 46 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X X X X| 12 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X X | 15 | Hepatocellular Adenoma, Multiple | X X X X | 5 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 4 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| | DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| | | 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | |__________________________________________________________________________|____________| Tooth | + + + | 7 | Odontoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | Adenoma | | 1 | Capsule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + I + + + M + M M + + M M + + + + + M + + M + + +| 41 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| | DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| | | 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + | 4 | Iliac, Lymphoma Malignant | X | 1 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Histiocytic Sarcoma | X | 1 | Renal, Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + M M + M M + M + + + + + M + + M + + + + M M M| 30 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M + M + + + + M + + M M + + + M M M + + + M M + +| 34 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 3 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + + M M + + + M + + + + + + + + + + + +| 37 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| | DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| | | 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 3 | |__________________________________________________________________________|____________| Thymus | + + M + + + M + + + + + + M + + + + + + + + + + +| 41 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X | 9 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 3 | Alveolar/Bronchiolar Carcinoma | X X X X | 6 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| | DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| | | 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 2 | |__________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | | 2 | Carcinoma | X | 1 | Bilateral, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | Renal Tubule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3| | 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + M A M + + A I + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + I + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + A + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + A A + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + A A + + + A + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + A + + + A A + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X X X X X X | Hepatocellular Adenoma, Multiple | X X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + | |__________________________________________________________________________| Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + A + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3| | 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + + + + + + + | Odontoma | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Capsule, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + M + + M + + + + + + M + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3| | 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Prostate | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | Pancreatic, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + M M + + + M + M + M + + M + + + M +| Lymphoma Malignant | X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M M M + + M M + M M + + M + + + M + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + M + M M + + + + M M + M + M + M + + + M + +| Lymphoma Malignant | X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X X | |__________________________________________________________________________| Thymus | + + + + M + + + + + + + M + M + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3| | 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X| Alveolar/Bronchiolar Carcinoma | X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Lymphoma Malignant | X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + + | __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3| | 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + A + + + + A + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| | | 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + A + + + + + + + + + A A M + + + + + + +| 40 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + A + + + + + + + + + A + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + A + + + + + + + + + A + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + + + + + + + + + A A + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + A A + + + + + + + +| 43 | Carcinoma | X | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + + + + + + + + + A A + + + + + + + +| 43 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X X | 12 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X X X | 20 | Hepatocellular Adenoma, Multiple | X X| 4 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 2 | |__________________________________________________________________________|____________| Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| | | 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Tooth | + + + + + +| 14 | Odontoma | X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | Capsule, Adenoma | X | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M M + M + + + + + +| 42 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| | | 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Prostate | + + + + + A + + + + + + I + + A + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + A + + + + + + + + + A + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node | + | 3 | Pancreatic, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M M + M + + + + M + + + + M + + M + M M| 33 | Lymphoma Malignant | | 1 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + M M M M + M + + + + M M + + M M + + M M| 29 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + M M + + + + + + + + + +| 38 | Lymphoma Malignant | | 2 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| | | 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Thymus | + + + + + A + + + + + + + + M M + M + + M + + + +| 42 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 2 | Alveolar/Bronchiolar Carcinoma | X | 5 | Alveolar/Bronchiolar Carcinoma, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| | | 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Multiple | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 4 | Lymphoma Malignant | | 2 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant | | 1 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7| DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0| | 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + A I + + + A M + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + A + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + A + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Hepatoblastoma | | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X X X| Hepatocellular Adenoma, Multiple | X X X | Histiocytic Sarcoma | X| Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7| DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0| | 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + | Odontoma | X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7| DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0| | 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Penis | + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| |__________________________________________________________________________| Lymph Node | + + | Lymphoma Malignant | | Iliac, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Bronchial | + M + + + + M M M + M M + + M M + + + M + + + + M| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | M + + M M + + M + M + + M + + + M M + M + + + M +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| Histiocytic Sarcoma | X| __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7| DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0| | 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + M + + + M M + + + + + M + + + + M M + + M M M +| Histiocytic Sarcoma | X| Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + M M + + M + + + + + + + + + + + + + M + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X | __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7| DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0| | 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X| Lymphoma Malignant | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X | Renal Tubule, Adenoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| | | 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + +| 45 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 2 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X X X X X X| 10 | Hepatocellular Carcinoma, Multiple | X X | 4 | Hepatocellular Adenoma | X X X X X X | 13 | Hepatocellular Adenoma, Multiple | X X | 5 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Mesentery | + + | 4 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| | | 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tooth | + + | 9 | Odontoma | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + M + + + + + M M + + + + + + + + + + M + + M| 42 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| | | 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Penis | + | 2 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + M + I + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 7 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| | | 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Iliac, Lymphoma Malignant | X X | 3 | Pancreatic, Lymphoma Malignant | X X | 2 | Renal, Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + M M + M + + M + + + + + + M + + M M + + + + M| 32 | Lymphoma Malignant | X X X | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + M + + + + + + + + M + + M + M M M| 33 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M + + + M + + + + M M + + + + M + + + + + + +| 36 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X | 3 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Thymus | M + + + M M + + + M M + + + + + + + + + + M + M M| 38 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangioma | X | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| | | 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 5 | Alveolar/Bronchiolar Carcinoma | X X X | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 2 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + + +| 4 | Adenoma | X X X| 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| | | 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Renal Tubule, Adenoma | X X | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3| | 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + A + M + + + M + M M + A I + + + A M + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + A + + + + A + + + + + +| Leiomyoma | | |__________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + A + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + A + + + + + +| Carcinoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + A + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + A + + + + + +| Hemangiosarcoma | X X | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X | |__________________________________________________________________________| Mesentery | + + | |__________________________________________________________________________| Pancreas | + + A + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + A + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + A + + + + + + + + + + A + + + + A + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3| | 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + + + + + + + +| Odontoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +| Capsule, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +| Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + A + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + M + + + + + + + + M + + + M + M| |__________________________________________________________________________| Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + + + +| Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3| | 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Seminal Vesicle | + + A + + + + + + + + + + A + + + + A + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + | |__________________________________________________________________________| Lymph Node, Bronchial | + + M M + + + + + M + + + M + + + M + + + + M + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | M + M + + + + + + + + M + + + + M M M + M + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +| Lymphoma Malignant | X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + M + + M M + M + M M + + M + + M + + M + M M + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + A + + + + + + + + + + A + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X | Lymphoma Malignant | X X | |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + A M + + + + M + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Sarcoma | | __________________________________________|__________________________________________________________________________| Page 80 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3| | 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + A + + + + A + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Lymphoma Malignant | X | |__________________________________________________________________________| Nose | + + A + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 _____________________________________________________________________________________________________________________ | 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3| | 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + A + + + + + + + + + + A + + + + A + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X | __________________________________________|__________________________________________________________________________| Page 82 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| | | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + A + + + M A A A + + + + + + M + + + M| 34 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + I + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + A A + + + + + A + + + + + A| 42 | Leiomyoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + A A A + + + + A + + + + + A| 42 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A A + + + + + A + + + + + A| 43 | Carcinoma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + A A + + + + + A + + + + + A| 42 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 2 | Hepatocellular Carcinoma | X X X X | 7 | Hepatocellular Carcinoma, Multiple | X X X| 7 | Hepatocellular Adenoma | X X X X X X | 10 | Hepatocellular Adenoma, Multiple | X X | 7 | |__________________________________________________________________________|____________| Mesentery | | 2 | |__________________________________________________________________________|____________| Pancreas | + + I + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| | | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Tooth | + + + + + + + | 16 | Odontoma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Adenoma | X X | 3 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Benign | | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Parathyroid Gland | M + M + + M + + + M + M + + + + M + M + + + + M +| 37 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + I| 48 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| | | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node | | 1 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M M M + M M + M + + + M M + + M M M M| 32 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + M + + M + M M M + + M + + + + + + + + M| 35 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 4 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + M M + + M + M + + + + M + + M + + M +| 31 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| | | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | X | 3 | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + M M + M + + + + + + + + + + +| 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Sarcoma | X| 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 3 | Alveolar/Bronchiolar Carcinoma | X | 3 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X | 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X| 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 NTP Experiment-Test: 88070-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ISOBUTENE Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:41:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| | | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + | 2 | |__________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | | 2 | Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 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