TDMS Study 88070-04 Pathology Tables
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
CORE STUDY
Facility: Battelle Northwest
Chemical CAS #: 115-11-0007
Lock Date: 10/05/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3|
| 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + A +|
Angiectasis | |
Basophilic Focus | X X X |
Cyst | |
Degeneration, Fatty | 1 |
Eosinophilic Focus | X X X X X X X X X |
Tension Lipidosis | |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Necrosis | 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + A +|
Basophilic Focus | |
Lipomatosis | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 2 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + A +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + M + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3|
| 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 1 2 1 2 2 1 2 2 1 2 3 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M M + + + + I I + + I + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cyst | 4 2 2 2 3 1|
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + M + + + + + M + M + + M M +|
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + M + + + + + M + + M +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + I + + + + + + A +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M + + M + + M + + + + M + + + M M M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + A +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 0| 3| 2| 3| 3| 3| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 7| 3|
| 5| 5| 9| 9| 5| 1| 5| 8| 5| 2| 5| 5| 5| 5| 7| 5| 9| 5| 5| 9| 5| 5| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 2 1 1 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 3 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Amyloid Deposition | |
Infarct | |
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| |
| 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + I| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X | 4 |
Cyst | 3 | 1 3.0|
Degeneration, Fatty | 2 | 2 1.5|
Eosinophilic Focus | X X X X X X X X | 17 |
Tension Lipidosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fat, Necrosis | 2 3 | 7 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Basophilic Focus | X | 1 |
Lipomatosis | 4 | 1 4.0|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Hyperplasia | | 2 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + A + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 2 1| 10 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia | 1 2 | 3 1.3|
Hypertrophy | 2 2 | 3 1.7|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| |
| 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M + + M + + M M + M A + + + M M + + + M +| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 4 2 3 1 2 3 1 1 3 | 13 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 1 2 3 1 1 1 3 2 1 1 2 2 | 25 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Cyst | 4 2 2 3 3 2 2 | 13 2.5|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hydrometra | 2 2 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Lumbar, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + M + + + M M + + A + + + + + + + + M +| 38 |
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + M + + + M + + + A + + M + + + + + + +| 41 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + M M + + + + + A + + + + + M + + + +| 38 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 4 | 4 3.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 2| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 6| 3| 3| 8| 3| 2| 3| |
| 3| 3| 5| 5| 6| 1| 6| 6| 6| 6| 6| 1| 6| 0| 0| 6| 6| 6| 7| 6| 6| 0| 6| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Alveolar Epithelium, Hyperplasia | 1 | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 2 2 2 1 1 2 2| 17 1.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 3 1 1 3 1 2 2 3 1 2 2| 21 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 4 | 1 4.0|
Infarct | 2 | 1 2.0|
Metaplasia, Osseous | 2 | 1 2.0|
Nephropathy | 2 2 1 1 2 2 1 | 13 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + I + M + + + + + + + A + + A + + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + M M + + A + + A + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + I + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + A + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Clear Cell Focus | X X X|
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X X X |
Necrosis | 2 |
Tension Lipidosis | X X |
__________________________________________________________________________|
Mesentery | + + +|
Artery, Inflammation | |
Fat, Necrosis | 2 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Duct, Cyst | 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | 1 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M M + + M + M + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 2 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 3 2 2 1 1 1 2 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 3 3 2 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M M + + M + M + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + M + + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + M + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 9| 9| 5| 2| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3|
| 5| 9| 5| 9| 5| 5| 5| 5| 1| 3| 7| 1| 5| 5| 6| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 2 1 2 1 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 1 2 1 2 1 2 1 3 1 2 1 1 1 2 1 2 1 2|
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Metaplasia, Squamous | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct | |
Metaplasia, Osseous | 2 |
Nephropathy | 1 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| |
| 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + I + + I + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X X | 4 |
Clear Cell Focus | X | 4 |
Degeneration, Fatty | 1 | 1 1.0|
Eosinophilic Focus | X X X X | 11 |
Necrosis | 2 | 2 2.0|
Tension Lipidosis | X | 3 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Artery, Inflammation | 3 | 1 3.0|
Fat, Necrosis | 2 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 3 | 4 2.0|
Inflammation, Acute | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 | 10 1.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 4 2.0|
Hypertrophy | 2 | 1 2.0|
Vacuolization Cytoplasmic | 4 | 2 3.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| |
| 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + M + + + M + + + M + + + + + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 1 3 3 1 3 2 | 15 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 2 2 2 | 16 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M M + + + + + + + + + + + + + + M + + + + + +| 46 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Cyst | 2 2 2 2 2 2 2 4 | 14 2.4|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 1 4 2| 7 2.1|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M M + M M + + + + + + + M M + + M M + M M M| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + + + + + M + + + M + M M + + + + +| 42 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M + + + + + + + + + + + M + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 2 3 3 3 2 2 2| 12 2.7|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + M + + + + + + + + + + + + + + + + + + M + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 4| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 3| 1| 8| 3| 3| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| |
| 3| 6| 1| 3| 9| 6| 6| 6| 6| 2| 4| 9| 6| 6| 6| 6| 6| 6| 7| 5| 6| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Metaplasia, Osseous | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 2 | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 1 1 1 1 1 1 1| 19 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 2 2 1 2 1 3 2 1 1 2 2 1 1 1 1 2| 39 1.5|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Metaplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Infarct | 3 3 | 2 3.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy | 1 1 2 3 1 1 1 1 2| 14 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + M + + + + + + + M + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Degeneration, Fatty | 3 1 |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Necrosis | 2 2 |
Tension Lipidosis | |
Bile Duct, Hyperplasia | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Tooth | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | |
Hypertrophy | |
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + A + + + + + + M + + + + + + M + M +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 2 3 2 3 1 2 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1 4 2 1 4 1 2 4 1 3 2 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + A + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + A + + + + + + + + + + + + + + + + +|
Cyst | 3 2 2 3 2|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Inflammation, Suppurative | |
Necrosis | 4 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + M + + + + + + + + + + M + + + + M M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M A M + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + M + + + + + + + I + + + +|
Infiltration Cellular, Mixed Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + M + + M + + + + + + M + + + + + + + M + +|
Infiltration Cellular, Mixed Cell | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + A + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 3| 0| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 7| 5| 5| 5| 5| 5| 5| 6| 0| 6| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 2 3 2 1 1 2 1 1 2 2 2 2 2 2 2 1 2 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Metaplasia, Osseous | 2 |
Mineralization | 1 |
Nephropathy | 2 1 1 1 1 1 2 1 1|
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| |
| 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + + + + + + A + + + A +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | I + + + + I + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + A +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + A + + + A +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + A + + + A +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + A + + + A +| 46 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 2 |
Clear Cell Focus | X | 3 |
Degeneration, Fatty | 1 1 2 | 5 1.6|
Eosinophilic Focus | X X X X X | 12 |
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | 2 | 3 2.0|
Tension Lipidosis | X | 1 |
Bile Duct, Hyperplasia | 2 | 1 2.0|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Fat, Necrosis | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 | 12 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | 2 2 3| 3 2.3|
Hypertrophy | 3 2 2 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| |
| 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + + M + + + + M M + + M + + + M +| 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Pars Distalis, Hyperplasia | 3 3 3 2 2 4 2 1 3| 19 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2 2 1 2 3 3 2 2 1 1 1 3 2 1| 29 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M M + + + + + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Ovary | + + + + + I + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 4 2 4 3 1 1 | 11 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 2 | 3 2.3|
Inflammation, Suppurative | 2 | 1 2.0|
Necrosis | | 1 4.0|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + M + + M + + + + + + + + +| 44 |
Infiltration Cellular, Mixed Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Mixed Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M M M + + M + + + + + + + M + + M + + + M| 36 |
Infiltration Cellular, Mixed Cell | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 9| 2| 0| 3| 3| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3| 0| 3| |
| 8| 6| 6| 6| 6| 6| 6| 6| 2| 8| 9| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 2 1 1 1 1 1 1| 24 1.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 1 1 2 1 1 1 2 1 2 2 2 1 1 1 2 2 2| 41 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | | 1 2.0|
Metaplasia, Osseous | 2 | 2 2.0|
Mineralization | | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 | 18 1.1|
Renal Tubule, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3|
| 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + M + + + + + + + + + + + + + M + A + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X |
Clear Cell Focus | X X X |
Cyst | |
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | 3 |
Mixed Cell Focus | X|
Necrosis | |
Centrilobular, Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Artery, Inflammation | 4 |
Fat, Inflammation, Chronic Active | 3 |
Fat, Necrosis | 3 2 3 2 3 2 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Lipomatosis | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
Artery, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3|
| 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 1 |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 3 3 2 4 2 2 1 2 4 4 3 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M M + + + + + + M M + + + + + + + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4|
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + M M + + M + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + A + + + + + +|
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M + + + + + + + M M + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 5| 3| 3| 3| 7| 2| 3| 0| 2| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3|
| 5| 5| 3| 5| 5| 5| 2| 9| 5| 1| 1| 3| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 3 3 2 2 3 3 2 2 2 3 2 3 2 3 3 3 3 3 3 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| |
| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + + + + + + + A + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + I + + + + + + + + + + + + + + + + + + + + + +| 48 |
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X| 5 |
Clear Cell Focus | X | 4 |
Cyst | 2 | 1 2.0|
Degeneration, Fatty | 2 | 1 2.0|
Eosinophilic Focus | X X | 7 |
Hematopoietic Cell Proliferation | | 1 3.0|
Mixed Cell Focus | | 1 |
Necrosis | 2 | 1 2.0|
Centrilobular, Necrosis | 2 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Artery, Inflammation | | 1 4.0|
Fat, Inflammation, Chronic Active | | 1 3.0|
Fat, Necrosis | 2 2 1 2 | 10 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Lipomatosis | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Artery, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 1 | 8 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| |
| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | 2 1 1 | 5 1.6|
Hypertrophy | 2 | 2 1.5|
Vacuolization Cytoplasmic | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M + + M + + M + + M + M + M + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 3 3 3 2 2 1 2 | 14 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 2 3 3 1 3 3 1 2 2 3 1| 30 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2| 3 3.0|
Cyst | 4 4 2 2 3 | 8 2.6|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Hydrometra | 3 3 3 | 4 3.0|
Endometrium, Hyperplasia, Cystic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + M + + + M + + M + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M + + M + + + + + + + M + + + + + + M M + M| 38 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + M + + + + + M +| 42 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 3 | 5 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 9| 2| 3| 3| 4| 3| 3| 3| 0| 3| 8| 3| 3| 3| 0| 3| 1| 3| 3| 0| 3| 3| 3| |
| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 9| 6| 7| 6| 6| 6| 3| 6| 7| 6| 6| 9| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infarct | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + M + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 2 2 1 1 1 1| 27 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 2 1 3 3 2 2 2 2 2 1 3 2 2 2 2 2 3 3 1 2 1 2| 48 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 2 1 1 1 1 3 1 | 12 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3|
| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X X X X |
Cyst | |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X |
Necrosis | |
Vacuolization Cytoplasmic, Focal | |
Centrilobular, Necrosis | 4 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 4 |
Fat, Necrosis | 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Tooth | + + + + |
Malformation | X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 |
Inflammation, Chronic | |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2|
Hypertrophy | 2 3 1 2 2 1 2 2 2 1 2 2 2 2 3 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3|
| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + I +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M + + M M M + M M + + + + + M M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + M + + + + + + M + M M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + M + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + M + + M + M + + M + + + + + M + M M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + M + M + + + + + M M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + I + + + + + + + + + + + +|
Cyst | 2 |
Prepuce, Inflammation, Chronic Active| 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 8| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 2| 6| 1| 9| 3| 3| 3| 3| 3| 0| 3| 3|
| 3| 0| 3| 3| 3| 3| 3| 3| 0| 3| 3| 1| 3| 6| 4| 5| 5| 3| 3| 3| 3| 3| 9| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 3 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Polyp, Inflammatory | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct | |
Metaplasia, Osseous | |
Mineralization | 1 |
Nephropathy | 2 1 2 1 2 2 1 2 1 2 2 1 2 2 1 2|
Papilla, Inflammation, Suppurative | |
Pelvis, Dilatation | 3 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| |
DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| |
| 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + A + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X| 7 |
Clear Cell Focus | X X X | 9 |
Cyst | 2 | 1 2.0|
Degeneration, Fatty | 1 | 2 1.5|
Eosinophilic Focus | X X X | 5 |
Necrosis | 3| 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Centrilobular, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Inflammation, Chronic Active | | 1 4.0|
Fat, Necrosis | 2 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + | 7 |
Malformation | X X | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 21 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Hyperplasia | 1 2 2 2 3 2 2 2 2 | 14 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| |
DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| |
| 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | 2 2 2 2 1 2 1 2 2 2 2 2 1 2 2 | 32 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + I + + + M + M M + + M M + + + + + M + + M + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 2 | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + M M + M + + + + + M + + M + + + + M M M| 30 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + + M + + M M + + + M M M + + + M M + +| 34 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + + M M + + + M + + + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Thymus | + + M + + + M + + + + + + M + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Prepuce, Inflammation, Chronic Active| 3 4 3 4 3 | 7 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 5| 6| 7| 3| |
DAY ON TEST | 2| 3| 5| 3| 3| 1| 8| 5| 0| 2| 3| 3| 0| 3| 8| 3| 3| 3| 9| 3| 3| 8| 9| 3| 9| |
| 7| 4| 3| 4| 4| 1| 0| 3| 8| 3| 4| 4| 8| 4| 7| 4| 4| 4| 2| 4| 4| 9| 5| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 1| 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 5 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Polyp, Inflammatory | 4 | 1 4.0|
Olfactory Epithelium, Atrophy | 2 | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 | 6 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Infarct | 2 | 1 2.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | | 1 1.0|
Nephropathy | 1 2 2 2 2 2 3 2 2 2 1 2 2 1 2 1 2 2 1 2 | 36 1.7|
Papilla, Inflammation, Suppurative | 2 2 1| 3 1.7|
Pelvis, Dilatation | 2 2 | 3 2.3|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Inflammation, Chronic Active | 3 3 2| 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3|
| 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M A M + + A I + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + I + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A A + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A A + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A A + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X |
Cyst | 2 |
Degeneration, Fatty | |
Eosinophilic Focus | X X X X |
Mixed Cell Focus | X |
Necrosis | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + A + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Tooth | + + + + + + + + |
Malformation | X X X X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 2 2 |
Hypertrophy | 2 1 2 3 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + M + + M + + + + + + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3|
| 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Infiltration Cellular, Plasma | |
Cell | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + M M + + + M + M + M + + M + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M M + + M M + M M + + M + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M M + + + + M M + M + M + M + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 0| 4| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 3|
| 3| 3| 3| 7| 3| 3| 3| 5| 6| 3| 3| 3| 6| 3| 3| 3| 5| 3| 3| 3| 4| 4| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Olfactory Epithelium, Atrophy | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Inflammation, Chronic Active | 4 |
Mineralization | |
Nephropathy | 1 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1|
Papilla, Inflammation, Suppurative | 2 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + A + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| |
| 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + + + + A A M + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + A A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + A A + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + A A + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X | 8 |
Clear Cell Focus | X X X | 4 |
Cyst | | 1 2.0|
Degeneration, Fatty | 1 | 1 1.0|
Eosinophilic Focus | | 4 |
Mixed Cell Focus | X | 2 |
Necrosis | 3 3 2 2 4 | 5 2.8|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Basophilic Focus | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Necrosis | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Tooth | + + + + + +| 14 |
Malformation | X X X X X| 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1| 18 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 2 | 10 2.1|
Hypertrophy | 2 1 3 2 2 2 1 2 2 2 3 2| 24 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M + M + + + + + +| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| |
| 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + A + + + + + + I + + A + + + + + + + + +| 46 |
Inflammation, Chronic Active | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | 3 | 1 3.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + M M + M + + + + M + + + + M + + M + M M| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M M M M + M + + + + M M + + M M + + M M| 29 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + M M + + + + + + + + + +| 38 |
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 | 3 2.7|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + A + + + + + + + + M M + M + + M + + + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 9| 3| 6| 3| 3| 3| 1| 1| 6| 3| 2| 0| 3| 4| 3| 3| 0| 8| 3| 3| |
| 4| 1| 4| 9| 4| 8| 4| 7| 4| 4| 4| 2| 6| 2| 4| 2| 1| 4| 9| 4| 4| 9| 3| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 4 4 4 4 | 6 3.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 1| 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 1 2| 6 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 | 2 3.0|
Olfactory Epithelium, Atrophy | | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 1 | 7 1.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 2 1 1 1 1 2 1 | 19 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 4.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 1 1 2 1 1 2 2 1 1 1 2 1 1 2 1 2 1 1| 39 1.3|
Papilla, Inflammation, Suppurative | 3 2 | 3 2.3|
Pelvis, Dilatation | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 4 4 | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0|
| 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A I + + + A M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X X X |
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X X |
Mixed Cell Focus | X |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Tooth | + + + + + + + |
Malformation | X X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 1 2 |
Hypertrophy | 2 1 4 2 3 2 2 1 2 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0|
| 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Infiltration Cellular, Plasma | |
Cell | 4 |
Iliac, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + M M M + M M + + M M + + + M + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M M + + M + M + + M + + + M M + M + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + M M + + + + + M + + + + M M + + M M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 |
__________________________________________________________________________|
Thymus | + + M M + + M + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 4 4 4 4 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 5| 7| 5| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 5| 6| 7| 3| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 8| 3| 5| 3| 3| 8| 8| 3| 3| 3| 3| 3| 3| 1| 2| 3| 8| 3| 8| 3| 0|
| 7| 3| 3| 5| 4| 3| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 7| 3| 1| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Olfactory Epithelium, Atrophy | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 2 1 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 3 1 1 2 2 1 1 1 2 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2|
Nephropathy | 1 1 2 2 1 1 3 3 2 1 1 2 2 1 2 1 1 1 |
Capsule, Inflammation, Chronic | |
Papilla, Inflammation, Suppurative | 2 3 1 2 |
Pelvis, Dilatation | 3 2 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Inflammation, Chronic Active | 3 3 4 4 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| |
| 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X | 6 |
Clear Cell Focus | X X X | 6 |
Degeneration, Fatty | 1 1 | 2 1.0|
Eosinophilic Focus | X X X X X | 11 |
Mixed Cell Focus | | 1 |
Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + | 9 |
Malformation | X X | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 2 1 1 1| 16 1.1|
Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 2 2 2 2 2 2| 15 1.9|
Hypertrophy | 1 2 1 2 1 2 2 2 1 1 1 2 2 2 | 24 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| |
| 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + M M + + + + + + + + + + M + + M| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Pars Distalis, Hyperplasia | 3 | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + M + I + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | 2 | 2 3.0|
Iliac, Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + M + + M + + + + + + M + + M M + + + + M| 32 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + M + + + + + + + + M + + M + M M M| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + M + + + + M M + + + + M + + + + + + +| 36 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 4 | 5 3.2|
__________________________________________________________________________|____________|
Thymus | M + + + M M + + + M M + + + + + + + + + + M + M M| 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 5| 7| 4| 7| 7| 7| 7| 7| 6| 6| 7| 6| 3| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 9| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| 2| 3| 5| 3| 8| 1| |
| 1| 9| 3| 2| 4| 8| 4| 4| 4| 4| 4| 6| 9| 4| 5| 9| 4| 4| 4| 9| 4| 3| 4| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 3 4 4 4 3 4| 13 3.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 3 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 2.0|
Olfactory Epithelium, Atrophy | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 2 1 2 1 2 2 2| 16 1.6|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 1 1 1 2 2 2 1 2 2 2 | 29 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + +| 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 4 2 3 | 4 2.8|
Nephropathy | 2 2 3 1 1 2 2 2 1 1 1 1 2 1 2 1 3 1 1 3| 38 1.6|
Capsule, Inflammation, Chronic | 1 | 1 1.0|
Papilla, Inflammation, Suppurative | 2 4 | 6 2.3|
Pelvis, Dilatation | 3 3 | 4 2.8|
Renal Tubule, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Gross Observation | | 1 |
Inflammation, Chronic Active | 3 4 4 | 7 3.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3|
| 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + M + + + M + M M + A I + + + A M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X |
Degeneration, Fatty | 1 1 2 2 1 |
Eosinophilic Focus | X X |
Necrosis | |
Vacuolization Cytoplasmic, Focal | 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 4|
Inflammation, Acute | 3|
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + +|
Malformation | X X X X X X X X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 1|
Hypertrophy | 1 1 3 3 2 2 2 2 2 3 2 2 3 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
Follicular Cell, Hyperplasia | 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3|
| 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + A + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Infiltration Cellular, Plasma | |
Cell | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + + + + + M + + + M + + + M + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + + + + + + M + + + + M M M + M + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M M + M + M M + + M + + M + + M + M M + +|
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + A + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + A M + + + + M + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 3 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + A + + + + A + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
_____________________________________________________________________________________________________________________
| 7| 7| 3| 4| 6| 7| 7| 7| 7| 4| 7| 5| 6| 6| 6| 5| 7| 7| 6| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 9| 6| 3| 3| 3| 3| 5| 3| 4| 3| 8| 0| 6| 3| 3| 8| 3| 3| 3| 1| 3| 3|
| 3| 7| 1| 9| 7| 3| 3| 3| 3| 7| 3| 7| 3| 9| 8| 2| 3| 3| 2| 3| 3| 3| 2| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
8000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + A + + + + + +|
Polyp, Inflammatory | 3 |
Nasolacrimal Duct, Polyp, | |
Inflammatory | 3|
Olfactory Epithelium, Atrophy | 2 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 2 1 1 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 3 3 2 2 2 2 2 1 2 3 2 2 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Metaplasia, Osseous | 2 |
Nephropathy | 1 1 2 2 2 1 1 1 2 1 3 2 1 1 1 2 1 2 2 1|
Papilla, Inflammation, Suppurative | 2 |
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + A + + + + A + + + + + +|
Inflammation, Chronic Active | 4 1 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| |
| 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + M A A A + + + + + + M + + + M| 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + I + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + A A + + + + + A + + + + + A| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A A A + + + + A + + + + + A| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A A + + + + + A + + + + + A| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + A A + + + + + A + + + + + A| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X| 5 |
Clear Cell Focus | X X X X| 10 |
Degeneration, Fatty | | 5 1.4|
Eosinophilic Focus | X X X X X | 7 |
Necrosis | 2| 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + I + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 4.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + | 16 |
Malformation | X X X X X X | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 | 19 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 1 2 2 2 2 2 | 16 1.9|
Hypertrophy | 2 2 3 1 1 1 2 2 2 2 1 1 2 | 29 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M + + + M + M + + + + M + M + + + + M +| 37 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| |
| 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + I| 48 |
Pars Distalis, Hyperplasia | 1 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 4 2 | 5 2.2|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Inflammation, Chronic Active | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Inflammation, Chronic Active | 3 3 1 2 | 4 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Iliac, Infiltration Cellular, Plasma | | |
Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M M M + M M + M + + + M M + + M M M M| 32 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M + + M + M M M + + M + + + + + + + + M| 35 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + M M + + M + M + + + + M + + M + + M +| 31 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 3 3 3| 4 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + M M + M + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prepuce, Inflammation, Chronic Active| 2 4 4 3 4 4 | 9 3.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 88070-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ISOBUTENE Date: 06/20/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:37:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 3| 3| 6| 7| 7| 6| 2| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 4| 7| 3| 8| 3| 3| 3| 9| 5| 3| 3| 3| 3| 3| 0| |
| 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 7| 0| 0| 6| 9| 4| 4| 5| 1| 1| 4| 4| 4| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
8000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Polyp, Inflammatory | | 1 3.0|
Nasolacrimal Duct, Polyp, | | |
Inflammatory | | 1 3.0|
Olfactory Epithelium, Atrophy | | 2 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 2 2 1 1 2 1 1| 17 1.4|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 3 1 3 1 2 2 3 2 2 1 1 1 1 2 2 2 1 1 2 1 1| 39 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cataract | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Metaplasia, Osseous | 2 | 2 2.0|
Nephropathy | 2 1 2 2 1 2 2 2 1 3 2 2 1 1 2 2 2 2 2 2| 40 1.7|
Papilla, Inflammation, Suppurative | 3 3 2 3 | 5 2.6|
Pelvis, Dilatation | 3 4 3 | 4 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
Inflammation, Chronic Active | 4 3 1 4 | 6 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
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