Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5180

TDMS Study 88070-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                        ISOBUTENE                                       DATE: 06/20/97       
EXPERIMENT: 88070 TEST: 04                                                                                     TIME: 12:53:55       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15313                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88070       
PATHOLOGIST: MILLER, R.                                                                                        CAS: 115-11-0007     
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                        ISOBUTENE                                       DATE: 06/20/97      
EXPERIMENT: 88070 TEST: 04                                                                                     TIME: 12:53:55      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-15313                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88070      
PATHOLOGIST: MILLER, R.                                                                                        CAS: 115-11-0007    
                                     ISOBUTENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      387   399   426   483   527   560   580   589   592   608                 |
 |      610   611   653   653   664   681   695   695   708   709                 |
 |      715   723                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      405   512   522   546   562   583   596   601   639   649                 |
 |      652   667   667   698   709   711   715   716                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      387   389   428   480   499   512   512   527   555   559                 |
 |      583   584   628   631   636   639   645   653   681   686                 |
 |      708   713   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                     ISOBUTENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 8000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      251   330   341   386   457   499   508   512   547   547                 |
 |      562   608   631   633   639   667   670   682   689   695                 |
 |      706   727                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                     ISOBUTENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  96.0  92.0  90.0  82.0  70.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  84.0  78.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2000 PPM   |   100.0 100.0 100.0 100.0  96.0  92.0  84.0  76.0  64.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 |8000 PPM   |   100.0 100.0  98.0  94.0  92.0  90.0  84.0  78.0  70.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      500 PPM      2000 PPM     8000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.0%        64.0%        54.0%        56.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.642      P=0.488N     P=0.835      P=0.977  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       603.1        619.4        581.0        558.5    |
 |NATURAL DEATHS (C)      |       (22.0)       (20.3)       (21.1)       (29.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       675.8        692.1        663.1        656.2    |
 |(STANDARD ERROR)        |       (13.3)       (10.6)       (14.5)       (17.6)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                     ISOBUTENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      230   322   378   449   541   580   608   610   621   639                 |
 |      653   667   667   681   709   709   723   723                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      483   506   567   572   594   611   611   615   639   639                 |
 |      639   649   653   653   691   695   695   727   731                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      477   509   543   600   618   620   628   675   686   692                 |
 |      709                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                     ISOBUTENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 8000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      527   565   583   596   617   645   653   672   687   701                 |
 |      703   709   709   715   721   721   729                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                     ISOBUTENE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  96.0  94.0  92.0  90.0  88.0  78.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |500 PPM    |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  90.0  72.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2000 PPM   |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  92.0  86.0  78.0      |
 |           |                                                                    |
 |           |                                                                    |
 |8000 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  92.0  86.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      500 PPM      2000 PPM     8000 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.0%        62.0%        78.0%        66.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.802N     P=1.000      P=0.182N     P=0.820N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       583.9        630.0        614.3        661.9    |
 |NATURAL DEATHS (C)      |       (34.3)       (15.3)       (23.2)       (15.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       680.6        695.1        708.4        710.2    |
 |(STANDARD ERROR)        |       (15.9)       ( 9.3)       ( 8.7)       ( 7.1)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                             ISOBUTENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        500 PPM          = 2
                                                        2000 PPM         = 3
                                                        8000 PPM         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1                                       4                     1 2
      |                                         4            4        112                2
   96 +                                                      44       31   13            2 2
      |                                                       4       4    13       1      2  2
P     |                                                               4          4  1  3    1 2  2
E     |                                                                          4     3 3  1   12  2
R  88 +                                                                                44       1  12  2
C     |                                                                                 43  3      1  1
E     |                                                                                  4  3  43      2     2
N     |                                                                                               1 1    22
T  80 +                                                                                        434  3   11    22
      |                                                                                          4      4      2  2
S     |                                                                                             3   41 34  1
U     |                                                                                                    33     2   2
R  72 +                                                                                                     44 1 1    2 2
V     |                                                                                                     33   14 1
I     |                                                                                                      33     1 1 22
V     |                                                                                                       33  4 4
A  64 +                                                                                                        3    341 12  2
L     |                                                                                                              44
      |                                                                                                             3 4411
      |                                                                                                                4 11
   56 +                                                                                                                 3 1 1
      |                                                                                                                     3
      |
      |
   48 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.
                                                             ISOBUTENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        500 PPM          = 2
                                                        2000 PPM         = 3
                                                        8000 PPM         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                                   1                                       2       4
      |
      |                                     1              1                        2   2   4    4
      |
   96 +                                                    1       1                    2     3  2  4
      |
      |                                                            1            1             3  22 4  3
      |
   92 +                                                                         1             1   2   23  3
      |
      |                                                                                       1    1  2  24   4
      |
P  88 +                                                                                            1    1 33  44
E     |
R     |                                                                                                 11 3   4  43
C     |
E  84 +                                                                                                  11  2    4334
N     |
T     |                                                                                                   1  1      33 4
      |
S  80 +                                                                                                      1 1     3  3
U     |
R     |                                                                                                      221  1    43   3
V     |
I  76 +                                                                                                       22
V     |
A     |                                                                                                           1 1   44
L     |
   72 +                                                                                                        2    12  1
      |
      |                                                                                                              22
      |
   68 +                                                                                                                 141 4
      |
      |                                                                                                               2   2 4
      |
   64 +                                                                                                                   1 1
      |
      |                                                                                                                     2
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.