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TDMS Study 88120-03 Pathology Tables

NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99
Route: DOSED FEED                                                                                                 Time: 12:45:07

                                                    FINAL #1 CORE STUDY RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  80-07-9

       Lock Date:  08/11/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11            9           12            5                                     
    Natural Death                                      3            3            3           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           38           34           35                                     
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                8 (16%)      4 (8%)       3 (6%)       4 (8%)                                
   Intestine Large, Cecum                             (50)         (49)         (50)         (50)                                   
      Inflammation                                                  1 (2%)                                                          
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)       1 (2%)       2 (4%)                                
      Basophilic Focus                                47 (94%)     48 (96%)     43 (86%)     36 (72%)                               
      Clear Cell Focus                                 2 (4%)       5 (10%)      1 (2%)       2 (4%)                                
      Eosinophilic Focus                               9 (18%)     10 (20%)     14 (28%)      7 (14%)                               
      Fatty Change                                     1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       9 (18%)     11 (22%)     12 (24%)     14 (28%)                               
      Inflammation                                    43 (86%)     44 (88%)     39 (78%)     30 (60%)                               
      Mixed Cell Focus                                 8 (16%)     19 (38%)      7 (14%)      9 (18%)                               
      Necrosis                                         3 (6%)                    1 (2%)       4 (8%)                                
      Pigmentation                                                               1 (2%)                                             
      Vacuolization Cytoplasmic                        7 (14%)     11 (22%)      9 (18%)      9 (18%)                               
      Bile Duct, Hyperplasia                           5 (10%)     12 (24%)     21 (42%)     32 (64%)                               
      Centrilobular, Degeneration                      1 (2%)       5 (10%)     10 (20%)      7 (14%)                               
      Centrilobular, Hypertrophy                                    2 (4%)      24 (48%)     38 (76%)                               
   Mesentery                                          (7)          (8)          (4)          (4)                                    
      Inflammation                                                  2 (25%)                                                         
      Artery, Inflammation                                          1 (13%)                   1 (25%)                               
      Fat, Necrosis                                    6 (86%)      6 (75%)      4 (100%)     3 (75%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                         10 (20%)      8 (16%)      8 (16%)      8 (16%)                               
      Cytoplasmic Alteration                                                     1 (2%)       1 (2%)                                
      Hyperplasia                                                   1 (2%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation                                     5 (10%)      2 (4%)       7 (14%)      3 (6%)                                
      Metaplasia, Hepatocyte                                                                  1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
      Artery, Inflammation                                          1 (2%)                    1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)       2 (4%)                                             
      Cytoplasmic Alteration                           1 (2%)       1 (2%)       1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                                                      1 (2%)                                             
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Ulcer                                                                      2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                          2 (4%)       1 (2%)                    3 (6%)                                
      Inflammation                                     1 (2%)       1 (2%)                                                          
      Mineralization                                                             1 (2%)       1 (2%)                                
      Ulcer                                            3 (6%)       1 (2%)       3 (6%)                                             
   Tooth                                                                                     (4)                                    
      Inflammation                                                                            1 (25%)                               
      Peridontal Tissue, Inflammation                                                         3 (75%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)                                                          
      Aorta, Inflammation                                                                     1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  30 (60%)     23 (46%)     23 (46%)     27 (54%)                               
      Inflammation                                     5 (10%)      4 (8%)                    1 (2%)                                
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Valve, Inflammation                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Angiectasis                                     27 (54%)     21 (42%)     26 (52%)     26 (52%)                               
      Degeneration, Cystic                             3 (6%)       1 (2%)       2 (4%)                                             
      Hyperplasia                                     14 (28%)     11 (22%)     19 (38%)     18 (36%)                               
      Hypertrophy                                      4 (8%)       4 (8%)       5 (10%)      3 (6%)                                
      Inflammation                                                               1 (2%)                                             
      Necrosis                                                                   1 (2%)       2 (4%)                                
      Vacuolization Cytoplasmic                        3 (6%)       6 (12%)      5 (10%)      1 (2%)                                
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Angiectasis                                                                2 (4%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      4 (8%)       8 (16%)      3 (6%)       1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Angiectasis                                     19 (38%)     17 (35%)     23 (46%)     21 (42%)                               
      Cyst                                             4 (8%)       4 (8%)                    3 (6%)                                
      Pars Distalis, Hyperplasia                      23 (46%)     28 (57%)     23 (46%)     24 (48%)                               
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Nervosa, Hyperplasia                                                  1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      C-Cell, Hyperplasia                             35 (70%)     38 (76%)     34 (68%)     23 (46%)                               
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (50)         (50)         (48)                                   
      Hyperplasia                                      6 (13%)      6 (12%)      6 (12%)      3 (6%)                                
      Inflammation                                    16 (34%)     17 (34%)     21 (42%)     18 (38%)                               
      Duct, Cyst                                       3 (6%)       5 (10%)      2 (4%)       3 (6%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)       2 (4%)       1 (2%)                                             
      Cyst                                             3 (6%)       7 (14%)      3 (6%)       2 (4%)                                
      Infiltration Cellular, Histiocyte                             2 (4%)       3 (6%)       1 (2%)                                
      Inflammation                                     1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Dilatation                                                                              1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hydrometra                                       2 (4%)                    4 (8%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Inflammation                                                  1 (2%)                    1 (2%)                                
      Cervix, Cyst, Squamous                                                     1 (2%)       1 (2%)                                
      Cervix, Hydrometra                                                         1 (2%)                                             
      Cervix, Hyperplasia, Squamous                                              1 (2%)                                             
      Cervix, Inflammation                             1 (2%)                    1 (2%)       2 (4%)                                
      Endometrium, Adenomyosis                                                                1 (2%)                                
      Endometrium, Hyperplasia, Cystic                 3 (6%)       7 (14%)      7 (14%)      6 (12%)                               
   Vagina                                                          (2)                                                              
      Hyperplasia                                                   1 (50%)                                                         
      Inflammation                                                  2 (100%)                                                        
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia                                      9 (18%)     12 (24%)      8 (16%)     12 (24%)                               
      Inflammation, Granulomatous                                                2 (4%)                                             
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (27)         (23)         (28)         (28)                                   
      Mediastinal, Congestion                                                                 1 (4%)                                
      Mediastinal, Ectasia                                                                    1 (4%)                                
      Mediastinal, Hyperplasia, Plasma Cell                         1 (4%)                                                          
      Mediastinal, Pigmentation                       26 (96%)     19 (83%)     26 (93%)     24 (86%)                               
   Lymph Node, Mandibular                             (49)         (50)         (48)         (50)                                   
      Ectasia                                          1 (2%)       8 (16%)      5 (10%)      5 (10%)                               
      Hyperplasia, Plasma Cell                                      4 (8%)       1 (2%)       5 (10%)                               
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                                           1 (2%)                                             
      Fibrosis                                                                   2 (4%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 3 (6%)       4 (8%)       7 (14%)      2 (4%)                                
      Infarct                                                                    1 (2%)                                             
      Pigmentation                                    25 (50%)     26 (52%)     28 (56%)     32 (64%)                               
      Capsule, Fibrosis                                             1 (2%)                                                          
      Lymphoid Follicle, Atrophy                                    1 (2%)       1 (2%)       3 (6%)                                
   Thymus                                             (46)         (48)         (50)         (48)                                   
      Atrophy                                         46 (100%)    46 (96%)     47 (94%)     48 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                                                       1 (2%)       1 (2%)                                
      Dilatation                                       2 (4%)                                                                       
      Galactocele                                      1 (2%)                    6 (12%)      1 (2%)                                
      Hyperplasia                                     14 (28%)     19 (38%)     20 (40%)     10 (20%)                               
   Skin                                               (50)         (50)         (50)         (49)                                   
      Inflammation                                                                            1 (2%)                                
      Ulcer                                                                                   2 (4%)                                
      Subcutaneous Tissue, Inflammation                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteopetrosis                                    2 (4%)       2 (4%)       6 (12%)      4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       2 (4%)                    1 (2%)                                             
      Inflammation                                                                            1 (2%)                                
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                                    1 (2%)       1 (2%)       1 (2%)                                
      Inflammation                                    23 (46%)     21 (42%)     23 (46%)     31 (62%)                               
      Necrosis                                                                                2 (4%)                                
      Pigmentation                                    40 (80%)     40 (80%)     42 (84%)     35 (70%)                               
      Thrombosis                                                    1 (2%)       1 (2%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 8 (16%)      7 (14%)      9 (18%)      9 (18%)                               
      Bronchiole, Hyperplasia                                       1 (2%)                                                          
      Mediastinum, Thrombosis                                                                 1 (2%)                                
      Serosa, Inflammation                                                                    1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     2 (4%)                    1 (2%)                                             
      Inflammation                                     3 (6%)       2 (4%)       4 (8%)       4 (8%)                                
      Nasolacrimal Duct, Inflammation                                                         1 (2%)                                
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)                       (4)                                    
      Atrophy                                                                                 1 (25%)                               
      Cataract                                         1 (33%)      2 (100%)                  3 (75%)                               
      Hemorrhage                                       1 (33%)                                1 (25%)                               
      Cornea, Edema                                                                           1 (25%)                               
      Retina, Degeneration                             1 (33%)      2 (100%)                  3 (75%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Glomerulosclerosis                                            1 (2%)                                                          
      Hydronephrosis                                   1 (2%)                                 1 (2%)                                
      Infarct                                                                    1 (2%)                                             
      Inflammation                                     1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Nephropathy                                     39 (78%)     43 (86%)     42 (84%)     42 (84%)                               
      Pigmentation                                     5 (10%)      2 (4%)       9 (18%)      9 (18%)                               
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
      Pelvis, Inflammation                             2 (4%)       1 (2%)                                                          
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Calculus Gross Observation                                                              1 (2%)                                
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Serosa, Fibrosis                                              1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             1 (2%)                                 1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           16           24           15                                     
    Natural Death                                      7            4            6            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           30           20           28                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                1 (2%)       4 (8%)       1 (2%)       2 (4%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Inflammation                                                               2 (4%)                                             
      Parasite Metazoan                                3 (6%)       6 (12%)      8 (16%)      7 (14%)                               
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Cecum                             (49)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation                                                                            1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Inflammation                                                               1 (2%)       1 (2%)                                
      Parasite Metazoan                                             1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                30 (60%)     29 (58%)     26 (52%)     27 (54%)                               
      Clear Cell Focus                                 6 (12%)     11 (22%)      2 (4%)       4 (8%)                                
      Degeneration, Cystic                             5 (10%)      4 (8%)       4 (8%)       6 (12%)                               
      Eosinophilic Focus                               6 (12%)      8 (16%)      6 (12%)      8 (16%)                               
      Fibrosis                                                                   1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                                    1 (2%)       1 (2%)       1 (2%)                                
      Hepatodiaphragmatic Nodule                       7 (14%)      5 (10%)     10 (20%)      4 (8%)                                
      Inflammation                                    18 (36%)     27 (54%)     19 (38%)     21 (42%)                               
      Mixed Cell Focus                                 7 (14%)     17 (34%)      8 (16%)     11 (22%)                               
      Necrosis                                         4 (8%)       1 (2%)       3 (6%)       4 (8%)                                
      Pigmentation                                     2 (4%)                                                                       
      Thrombosis                                                    1 (2%)       2 (4%)                                             
      Vacuolization Cytoplasmic                        9 (18%)      4 (8%)       2 (4%)       5 (10%)                               
      Bile Duct, Hyperplasia                          46 (92%)     47 (94%)     44 (88%)     48 (96%)                               
      Centrilobular, Degeneration                     18 (36%)     15 (30%)     20 (40%)     23 (46%)                               
      Centrilobular, Hypertrophy                                    1 (2%)       3 (6%)      16 (32%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis                          1 (2%)       1 (2%)       1 (2%)                                             
   Mesentery                                          (7)          (12)         (12)         (14)                                   
      Hemorrhage                                                    1 (8%)       1 (8%)                                             
      Inflammation                                                  1 (8%)       1 (8%)                                             
      Necrosis                                         1 (14%)                                                                      
      Fat, Inflammation                                1 (14%)      1 (8%)                    2 (14%)                               
      Fat, Necrosis                                    3 (43%)      7 (58%)      8 (67%)      7 (50%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                         14 (28%)     14 (28%)     13 (26%)     12 (24%)                               
      Cytoplasmic Alteration                           2 (4%)       2 (4%)                    1 (2%)                                
      Hyperplasia                                      3 (6%)       2 (4%)                    2 (4%)                                
      Inflammation                                     1 (2%)       4 (8%)       4 (8%)       2 (4%)                                
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation                                                       2 (4%)                                             
      Duct, Cyst                                                                 1 (2%)       1 (2%)                                
      Duct, Hyperplasia                                             1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration                           1 (2%)                                 2 (4%)                                
      Duct, Hyperplasia                                1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      2 (4%)       2 (4%)       1 (2%)                                             
      Inflammation                                     1 (2%)       1 (2%)                                                          
      Ulcer                                            2 (4%)                    3 (6%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)                                                          
      Erosion                                          2 (4%)       1 (2%)       4 (8%)       3 (6%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Mineralization                                                             1 (2%)       1 (2%)                                
      Necrosis                                                                                1 (2%)                                
      Ulcer                                            2 (4%)       2 (4%)       4 (8%)       2 (4%)                                
   Tooth                                              (1)                       (1)                                                 
      Gingiva, Inflammation                                                      1 (100%)                                           
      Peridontal Tissue, Inflammation                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 (2%)                                                                       
      Aorta, Inflammation                                                                     1 (2%)                                
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  39 (78%)     46 (92%)     43 (86%)     43 (86%)                               
      Inflammation                                     1 (2%)                                                                       
      Thrombosis                                       1 (2%)       5 (10%)      5 (10%)      2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Artery, Inflammation                                                       1 (2%)                                             
      Endocardium, Degeneration                                                  1 (2%)                                             
      Epicardium, Hyperplasia                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Atrophy                                                                    1 (2%)                                             
      Degeneration, Cystic                             1 (2%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia                                     11 (22%)     13 (26%)      8 (16%)      9 (18%)                               
      Hypertrophy                                      3 (6%)       7 (14%)      3 (6%)       2 (4%)                                
      Necrosis                                         2 (4%)                                                                       
      Vacuolization Cytoplasmic                        8 (16%)      6 (12%)      4 (8%)       3 (6%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                     14 (28%)     10 (20%)     15 (30%)     12 (24%)                               
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (46)         (48)         (47)         (46)                                   
      Hyperplasia, Focal                                            1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                      7 (14%)      6 (12%)      6 (12%)      3 (6%)                                
      Cyst                                             2 (4%)       8 (16%)     10 (20%)      6 (12%)                               
      Hemorrhage                                       1 (2%)                    2 (4%)                                             
      Pars Distalis, Hyperplasia                      15 (30%)     17 (34%)     21 (42%)     15 (30%)                               
      Pars Distalis, Pseudocyst                        6 (12%)                                1 (2%)                                
      Pars Intermedia, Cyst                            1 (2%)                                                                       
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
      Pars Intermedia, Pseudocyst                      3 (6%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 (2%)                                                                       
      C-Cell, Hyperplasia                             19 (38%)     30 (60%)     26 (52%)     20 (40%)                               
      Follicular Cell, Hyperplasia                                               3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Mesothelium, Hyperplasia                                      1 (2%)       1 (2%)                                             
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                4 (8%)       2 (4%)                                
      Inflammation                                    46 (92%)     45 (90%)     48 (96%)     48 (96%)                               
      Duct, Cyst                                                    3 (6%)       2 (4%)       2 (4%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Cyst                                                          1 (2%)                                                          
      Inflammation                                    27 (54%)     38 (76%)     31 (62%)     29 (58%)                               
      Dorsal, Cyst, Mucous                                          1 (2%)       1 (2%)       1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                                                       
      Inflammation                                     1 (2%)                    1 (2%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          5 (10%)      7 (14%)      3 (6%)       6 (12%)                               
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Artery, Inflammation                             1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  28 (56%)     37 (74%)     28 (56%)     24 (48%)                               
      Mesothelium, Hyperplasia                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     18 (36%)     18 (36%)     16 (32%)     20 (40%)                               
      Inflammation, Granulomatous                                                1 (2%)                                             
      Myelofibrosis                                    4 (8%)       2 (4%)       1 (2%)       2 (4%)                                
      Necrosis                                         1 (2%)                    1 (2%)                                             
   Lymph Node                                         (15)         (11)         (14)         (14)                                   
      Inguinal, Hyperplasia, Plasma Cell                            1 (9%)                                                          
      Mediastinal, Atrophy                                          1 (9%)                                                          
      Mediastinal, Ectasia                                          1 (9%)                                                          
      Mediastinal, Hemorrhage                                                                 1 (7%)                                
      Mediastinal, Necrosis                            1 (7%)                                                                       
      Mediastinal, Pigmentation                        4 (27%)      1 (9%)       4 (29%)      3 (21%)                               
      Pancreatic, Necrosis                                          1 (9%)                                                          
      Renal, Hyperplasia, Plasma Cell                  1 (7%)                                                                       
      Renal, Necrosis                                  1 (7%)                                                                       
   Lymph Node, Mandibular                             (50)         (50)         (49)         (50)                                   
      Ectasia                                          3 (6%)       5 (10%)      3 (6%)       2 (4%)                                
      Hyperplasia, Plasma Cell                         4 (8%)       1 (2%)                                                          
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Atrophy                                          1 (2%)                                 1 (2%)                                
      Ectasia                                                       1 (2%)                    1 (2%)                                
      Hyperplasia, Reticulum Cell                                   2 (4%)                                                          
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1 (2%)       1 (2%)                    2 (4%)                                
      Fibrosis                                         2 (4%)       4 (8%)       4 (8%)       5 (10%)                               
      Hematopoietic Cell Proliferation                 4 (8%)       5 (10%)      3 (6%)       5 (10%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Reticulum Cell                                   1 (2%)       1 (2%)                                             
      Hyperplasia, Stromal                             1 (2%)                                                                       
      Infarct                                                       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Lipocyte                                            1 (2%)                                             
      Necrosis                                         1 (2%)                                 1 (2%)                                
      Pigmentation                                     1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Lymphoid Follicle, Atrophy                       2 (4%)                    3 (6%)       2 (4%)                                
   Thymus                                             (46)         (47)         (46)         (47)                                   
      Atrophy                                         44 (96%)     45 (96%)     40 (87%)     43 (91%)                               
      Artery, Inflammation                                          1 (2%)                                                          
      Epithelial Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (50)         (48)         (50)                                   
      Cyst                                             1 (2%)                    1 (2%)                                             
      Galactocele                                                                             2 (4%)                                
      Hyperplasia                                      2 (4%)       8 (16%)      9 (19%)      6 (12%)                               
      Inflammation                                     1 (2%)                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Edema                                                                      1 (2%)                                             
      Fibrosis                                                                                1 (2%)                                
      Hyperkeratosis                                                1 (2%)                    1 (2%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation                                                  1 (2%)       1 (2%)       1 (2%)                                
      Ulcer                                            1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteopetrosis                                    1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                                    1 (2%)       1 (2%)                                
      Hemorrhage                                       2 (4%)       1 (2%)       4 (8%)       3 (6%)                                
      Necrosis                                         1 (2%)                    4 (8%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Spinal Cord                                        (1)                                                                           
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Edema                                                                      1 (2%)       1 (2%)                                
      Foreign Body                                     1 (2%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                       2 (4%)                    3 (6%)       4 (8%)                                
      Inflammation                                    11 (22%)     16 (32%)     14 (28%)     18 (36%)                               
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                       1 (2%)       1 (2%)       2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                 9 (18%)      7 (14%)      2 (4%)       5 (10%)                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     5 (10%)      6 (12%)      3 (6%)       5 (10%)                               
      Inflammation                                    12 (24%)      9 (18%)      6 (12%)      8 (16%)                               
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)          (1)                                    
      Cataract                                                                   1 (100%)     1 (100%)                              
      Retina, Degeneration                                                       1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Infarct                                          1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
      Inflammation                                                  2 (4%)                                                          
      Necrosis                                                                   2 (4%)                                             
      Nephropathy                                     42 (84%)     48 (96%)     41 (82%)     44 (88%)                               
      Pigmentation                                    13 (26%)      4 (8%)      15 (30%)     19 (38%)                               
      Thrombosis                                                                 1 (2%)                                             
      Artery, Inflammation                             1 (2%)                                                                       
      Pelvis, Inflammation                                                       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88120-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:45:07  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Degeneration                       1 (2%)                                                                       
   Urethra                                                                      (1)                                                 
      Inflammation                                                               1 (100%)                                           
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Inflammation                                                               2 (4%)                                             
      Transitional Epithelium, Hyperplasia                                       2 (4%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

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