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TDMS Study 88120-03 Pathology Tables

NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99
Route: DOSED FEED                                                                                                 Time: 12:52:29

                                                    FINAL #1 CORE STUDY RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  80-07-9

       Lock Date:  08/11/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11            9           12            5                                     
    Natural Death                                      3            3            3           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           38           34           35                                     
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Schwannoma Malignant, Metastatic, Heart                       1 (2%)                                                          
   Mesentery                                          (7)          (8)          (4)          (4)                                    
      Sarcoma NOS, Metastatic, Uterus                  1 (14%)                                                                      
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
      Sarcoma NOS, Metastatic, Uterus                  1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                                          (2)                       (1)                                    
      Squamous Cell Carcinoma                                       1 (50%)                   1 (100%)                              
      Squamous Cell Papilloma                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                          1 (2%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)       2 (4%)       1 (2%)                                             
      Sarcoma NOS, Metastatic, Uterus                  1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                                  1 (2%)                                             
      Pars Distalis, Adenoma                          23 (46%)     13 (27%)     17 (34%)      8 (16%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  3 (6%)       8 (16%)      6 (12%)      2 (4%)                                
      C-Cell, Adenoma, Multiple                        2 (4%)                                                                       
      C-Cell, Carcinoma                                2 (4%)                                 1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Leiomyoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (50)         (50)         (48)                                   
      Adenoma                                          1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
      Carcinoma                                                                  1 (2%)       1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor Malignant                                                          1 (2%)                                
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
      Sarcoma NOS, Metastatic, Uterus                  1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Polyp Stromal                                   10 (20%)      8 (16%)      5 (10%)      5 (10%)                               
      Sarcoma NOS                                      1 (2%)                                                                       
      Sarcoma Stromal                                  1 (2%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (27)         (23)         (28)         (28)                                   
      Lumbar, Carcinoma, Metastatic, Clitoral Gland                                           1 (4%)                                
   Lymph Node, Mandibular                             (49)         (50)         (48)         (50)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Thymus                                             (46)         (48)         (50)         (48)                                   
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)                                             
      Carcinoma, Multiple                                                                     1 (2%)                                
      Fibroadenoma                                    12 (24%)     18 (36%)     19 (38%)      8 (16%)                               
      Fibroadenoma, Multiple                           3 (6%)       2 (4%)       1 (2%)                                             
      Myoepithelioma                                   1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (49)                                   
      Pinna, Melanoma Malignant                                     1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  2 (4%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)       1 (2%)                    1 (2%)                                
      Oligodendroglioma Malignant                                                             1 (2%)                                
   Peripheral Nerve                                   (1)                       (1)                                                 
      Trigeminal, Schwannoma Malignant                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Carcinoma, Metastatic, Clitoral Gland                                                   1 (2%)                                
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Sarcoma NOS, Metastatic, Uterus                  1 (2%)                                                                       
      Mediastinum, Sarcoma NOS, Metastatic, Uterus     1 (2%)                                                                       
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Sarcoma NOS                                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Sarcoma NOS, Metastatic, Uterus                  1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Sarcoma NOS, Metastatic, Uterus                  1 (2%)                                                                       
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                             8 (16%)      7 (14%)     14 (28%)     14 (28%)                               
      Lymphoma Malignant                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          40          42          36                                       
     Total Primary Neoplasms                           79          74          73          57                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          35          35          20                                       
     Total Benign Neoplasms                            63          59          52          28                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          14          20          25                                       
     Total Malignant Neoplasms                         16          15          21          29                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           1           2                                       
     Total Metastatic Neoplasm                          9           1           1           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           16           24           15                                     
    Natural Death                                      7            4            6            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           30           20           28                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Lipoma                                                                     1 (2%)                                             
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
   Intestine Large, Cecum                             (49)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Hepatocellular Carcinoma                         2 (4%)                                 1 (2%)                                
      Hepatocellular Adenoma                                                                  2 (4%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
   Mesentery                                          (7)          (12)         (12)         (14)                                   
   Pancreas                                           (50)         (50)         (50)         (50)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                             2 (4%)                    1 (2%)                                             
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Skin           1 (2%)                                                                       
      Vena Cava, Pheochromocytoma Malignant,                                                                                        
          Metastatic, Adrenal Medulla                  1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                                       1 (2%)                                             
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       2 (4%)                    2 (4%)       1 (2%)                                
      Pheochromocytoma Malignant, Multiple                          1 (2%)                                                          
      Pheochromocytoma Benign                          4 (8%)       3 (6%)       7 (14%)      1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    2 (4%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          11 (22%)     13 (26%)      7 (14%)     11 (22%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      C-Cell, Adenoma                                  7 (14%)      6 (12%)      4 (8%)       7 (14%)                               
      C-Cell, Adenoma, Multiple                        1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      C-Cell, Carcinoma                                             1 (2%)       1 (2%)       2 (4%)                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                       (1)                                    
   Tissue NOS                                                      (1)                                                              
      Thoracic, Schwannoma Malignant                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       3 (6%)       1 (2%)       3 (6%)                                
      Carcinoma                                                     2 (4%)                    1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Seminoma Malignant                                                         1 (2%)                                             
      Interstitial Cell, Adenoma                       2 (4%)       3 (6%)                    2 (4%)                                
      Interstitial Cell, Adenoma, Multiple            39 (78%)     43 (86%)     45 (90%)     47 (94%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (15)         (11)         (14)         (14)                                   
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Lung                                          1 (9%)                                                          
   Lymph Node, Mandibular                             (50)         (50)         (49)         (50)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Sarcoma NOS                                                                             1 (2%)                                
   Thymus                                             (46)         (47)         (46)         (47)                                   
      Squamous Cell Carcinoma, Metastatic, Lung                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (50)         (48)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
      Fibroadenoma                                     3 (6%)       6 (12%)      3 (6%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                               1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Keratoacanthoma                                  3 (6%)       5 (10%)      2 (4%)       4 (8%)                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Trichoepithelioma                                1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Melanoma Malignant                       1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma NOS                 1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (2)                       (1)                                    
      Sarcoma NOS, Metastatic, Skin                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Ependymoma Malignant                                          1 (2%)                                                          
      Glioma Malignant                                 1 (2%)                                                                       
      Meningioma Malignant                                                       1 (2%)                                             
      Oligodendroglioma Malignant                                                2 (4%)                                             
   Spinal Cord                                        (1)                                                                           
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - cont                                                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Liver                       1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin           1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)       1 (2%)                    1 (2%)                                
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)       1 (2%)       1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Lung                     1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)          (1)          (1)                                    
      Carcinoma                                        1 (100%)     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Mesenchymal Tumor Malignant                                   1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma, Metastatic, Liver                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            27 (54%)     22 (44%)     25 (50%)     27 (54%)                               
      Mesothelioma Malignant                           2 (4%)       2 (4%)       5 (10%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  10                                                               
NTP Experiment-Test: 88120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:52:29  
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         FISCHER 344 RATS MALE                     0 PPM        10 PPM       30 PPM       100 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          122         126         121         127                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          48          47          50                                       
     Total Benign Neoplasms                            81          89          77          84                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          33          37          37                                       
     Total Malignant Neoplasms                         41          37          44          43                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           4           1           2                                       
     Total Metastatic Neoplasm                          9           7           3           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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