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TDMS Study 88120-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 10/27/99       
EXPERIMENT: 88120 TEST: 03                                                                                     TIME: 12:53:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B       
PATHOLOGIST: SINGER, ALLEN                                                                                     CAS: 80-07-9         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                      FINAL #1 CORE STUDY RATS                                                      
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 10/27/99

EXPERIMENT: 88120 TEST: 03                                                                                     TIME: 12:53:23
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B
PATHOLOGIST: SINGER, ALLEN                                                                                     CAS: 80-07-9

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Brain
                                                 Clitoral/Preputial Gland
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pancreas
                                                 Pituitary Gland
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 10/27/99     
EXPERIMENT: 88120 TEST: 03                                                                                     TIME: 12:53:23     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B     
PATHOLOGIST: SINGER, ALLEN                                                                                     CAS: 80-07-9       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF           P,P'-DICHLORODIPHENYL SULFONE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Liver                                  Hepatocellular Adenoma
Testes                                 Adenoma
All Organs                             Benign Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Ovary                                  Granulosa Cell Tumor: Benign, Malignant, NOS
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Benign Tumors
                                       Malignant Tumors
===============================================================
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         4.4%         2.2%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |2/36 (6%)    1/38 (3%)    1/35 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      666          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.151N     P=0.672N     P=0.510N     P=0.244N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.150N     P=0.689N     P=0.489N     P=0.247N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.148N     P=0.691N     P=0.493N     P=0.244N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.152N     P=0.684N     P=0.486N     P=0.248N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.148N     P=0.692N     P=0.510N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.141N     P=0.691N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    7/50 (14%)   1/50 (2%)   |2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.9%         6.8%         17.1%        2.4%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    2/30 (7%)    3/20 (15%)   1/28 (4%)   |2/36 (6%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     640          603          614          729 (T)     |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.147N     P=0.406N     P=0.231      P=0.151N    |P=0.250N     P=0.226N     P=0.244N     P=0.244N     |
|POLY 3             |     P=0.143N     P=0.453N     P=0.266      P=0.162N    |P=0.244N     P=0.238N     P=0.230N     P=0.247N     |
|POLY 1.5           |     P=0.142N     P=0.469N     P=0.269      P=0.166N    |P=0.242N     P=0.240N     P=0.233N     P=0.244N     |
|POLY 6             |     P=0.149N     P=0.437N     P=0.258      P=0.162N    |P=0.246N     P=0.235N     P=0.228N     P=0.248N     |
|LOGISTIC REGRESSION|     P=0.142N     P=0.468N     P=0.261      P=0.160N    |P=0.250N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.151N     P=0.500N     P=0.262      P=0.181N    |P=0.241N     P=0.253N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         2.3%         4.9%         2.4%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     2/24 (8%)    1/30 (3%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      549          729 (T)     |---          730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.452N     P=0.422N     P=0.663      P=0.446N    |P=0.585N     P=0.511      (e)          (e)          |
|POLY 3             |     P=0.475N     P=0.469N     P=0.684N     P=0.478N    |P=0.575N     P=0.499      (e)          (e)          |
|POLY 1.5           |     P=0.474N     P=0.480N     P=0.685N     P=0.483N    |P=0.576N     P=0.497      (e)          (e)          |
|POLY 6             |     P=0.479N     P=0.457N     P=0.686N     P=0.475N    |P=0.574N     P=0.501      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.471N     P=0.422N     P=0.693N     P=0.446N    |(e)          P=0.511      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.479N     P=0.500N     P=0.691N     P=0.500N    |P=0.575N     P=0.495      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    9/50 (18%)   2/50 (4%)   |2/50 (4%)    1/49 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     14.9%        9.1%         21.6%        4.7%        |4.5%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     3/24 (13%)   3/30 (10%)   3/20 (15%)   2/28 (7%)   |2/36 (6%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     640          603          549          729 (T)     |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.261N     P=0.248      P=0.100N    |P=0.177N     P=0.481N     P=0.244N     P=0.244N     |
|POLY 3             |     P=0.122N     P=0.315N     P=0.308      P=0.115N    |P=0.172N     P=0.502N     P=0.230N     P=0.247N     |
|POLY 1.5           |     P=0.121N     P=0.333N     P=0.305      P=0.119N    |P=0.171N     P=0.504N     P=0.233N     P=0.244N     |
|POLY 6             |     P=0.129N     P=0.297N     P=0.308      P=0.114N    |P=0.174N     P=0.498N     P=0.228N     P=0.248N     |
|LOGISTIC REGRESSION|     P=0.121N     P=0.312N     P=0.292      P=0.110N    |P=0.177N     P=0.481N     (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.131N     P=0.370N     P=0.288      P=0.134N    |P=0.168N     P=0.508N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma Malignant                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         0.0%        |0.0%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          549          ---         |---          ---          ---          347          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.671N     (e)          P=0.234      (e)         |P=0.211      (e)          (e)          P=0.496      |
|POLY 3             |     P=0.669N     (e)          P=0.244      (e)         |P=0.210      (e)          (e)          P=0.496      |
|POLY 1.5           |     P=0.669N     (e)          P=0.243      (e)         |P=0.212      (e)          (e)          P=0.497      |
|POLY 6             |     P=0.672N     (e)          P=0.244      (e)         |P=0.209      (e)          (e)          P=0.495      |
|LOGISTIC REGRESSION|     P=0.756      (e)          P=0.192      (e)         |P=0.752      (e)          (e)          P=0.931      |
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |P=0.214      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         4.9%         0.0%        |2.2%         2.2%         0.0%         4.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     312          ---          549          ---         |414          730 (T)      ---          347          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.439N     P=0.500N     P=0.494      P=0.500N    |P=0.322      P=0.757N     P=0.500N     P=0.490      |
|POLY 3             |     P=0.443N     P=0.487N     P=0.504      P=0.492N    |P=0.326      P=0.759      P=0.497N     P=0.489      |
|POLY 1.5           |     P=0.440N     P=0.492N     P=0.504      P=0.494N    |P=0.328      P=0.759      P=0.498N     P=0.492      |
|POLY 6             |     P=0.448N     P=0.481N     P=0.503      P=0.491N    |P=0.325      P=0.760      P=0.496N     P=0.489      |
|LOGISTIC REGRESSION|     P=0.704N     (e)          P=0.315      (e)         |P=0.552      P=0.763N     (e)          P=0.763      |
|COCH-ARM / FISHERS |     P=0.441N     P=0.500N     P=0.500      P=0.500N    |P=0.333      P=0.753N     P=0.500N     P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |1/47 (2%)    3/50 (6%)    1/50 (2%)    3/48 (6%)    |
|POLY-3 ADJUSTED (b)|     7.5%         6.9%         2.5%         7.1%        |2.3%         6.7%         2.2%         7.3%         |
|TERMINAL (d)       |     2/24 (8%)    2/30 (7%)    0/20 (0%)    2/28 (7%)   |1/36 (3%)    3/38 (8%)    1/35 (3%)    2/34 (6%)    |
|FIRST INCIDENCE    |     611          709          725          699         |730 (T)      730 (T)      730 (T)      633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.606      P=0.577N     P=0.363N     P=0.607N    |P=0.308      P=0.324      P=0.756      P=0.285      |
|POLY 3             |     P=0.594      P=0.625N     P=0.305N     P=0.637N    |P=0.317      P=0.321      P=0.746N     P=0.291      |
|POLY 1.5           |     P=0.592      P=0.637N     P=0.302N     P=0.642N    |P=0.324      P=0.323      P=0.746N     P=0.298      |
|POLY 6             |     P=0.592      P=0.612N     P=0.312N     P=0.636N    |P=0.313      P=0.319      P=0.747N     P=0.287      |
|LOGISTIC REGRESSION|     P=0.594      P=0.617N     P=0.303N     P=0.633N    |P=0.309      P=0.324      P=0.756      P=0.295      |
|COCH-ARM / FISHERS |     P=0.582      P=0.661N     P=0.309N     P=0.661N    |P=0.340      P=0.332      P=0.737N     P=0.316      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/47 (0%)    0/50 (0%)    1/50 (2%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.5%         0.0%         2.3%        |0.0%         0.0%         2.2%         2.4%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     ---          603          ---          562         |---          ---          714          701          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.619      P=0.261      (e)          P=0.513     |P=0.291      (e)          P=0.505      P=0.495      |
|POLY 3             |     P=0.644      P=0.261      (e)          P=0.515     |P=0.282      (e)          P=0.513      P=0.491      |
|POLY 1.5           |     P=0.636      P=0.252      (e)          P=0.511     |P=0.288      (e)          P=0.513      P=0.495      |
|POLY 6             |     P=0.651      P=0.271      (e)          P=0.518     |P=0.278      (e)          P=0.513      P=0.488      |
|LOGISTIC REGRESSION|     P=0.571      P=0.207      (e)          P=0.397     |P=0.290      (e)          P=0.513      P=0.498      |
|COCH-ARM / FISHERS |     P=0.617      P=0.247      (e)          P=0.500     |P=0.300      (e)          P=0.515      P=0.505      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   1/50 (2%)    4/50 (8%)   |1/47 (2%)    3/50 (6%)    2/50 (4%)    4/48 (8%)    |
|POLY-3 ADJUSTED (b)|     7.5%         11.3%        2.5%         9.3%        |2.3%         6.7%         4.4%         9.7%         |
|TERMINAL (d)       |     2/24 (8%)    2/30 (7%)    0/20 (0%)    2/28 (7%)   |1/36 (3%)    3/38 (8%)    1/35 (3%)    2/34 (6%)    |
|FIRST INCIDENCE    |     611          603          725          562         |730 (T)      730 (T)      714          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.553      P=0.447      P=0.363N     P=0.559     |P=0.165      P=0.324      P=0.497      P=0.168      |
|POLY 3             |     P=0.555      P=0.410      P=0.305N     P=0.537     |P=0.168      P=0.321      P=0.523      P=0.167      |
|POLY 1.5           |     P=0.549      P=0.391      P=0.302N     P=0.528     |P=0.174      P=0.323      P=0.523      P=0.172      |
|POLY 6             |     P=0.557      P=0.432      P=0.312N     P=0.544     |P=0.166      P=0.319      P=0.523      P=0.165      |
|LOGISTIC REGRESSION|     P=0.541      P=0.381      P=0.303N     P=0.518     |P=0.161      P=0.324      P=0.520      P=0.171      |
|COCH-ARM / FISHERS |     P=0.529      P=0.357      P=0.309N     P=0.500     |P=0.187      P=0.332      P=0.523      P=0.187      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.4%         0.0%        |0.0%         2.2%         4.4%         4.7%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    1/38 (3%)    2/35 (6%)    2/35 (6%)    |
|FIRST INCIDENCE    |     ---          ---          400          ---         |---          730 (T)      730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.772N     (e)          P=0.517      (e)         |P=0.212      P=0.511      P=0.232      P=0.232      |
|POLY 3             |     P=0.776N     (e)          P=0.506      (e)         |P=0.212      P=0.502      P=0.244      P=0.228      |
|POLY 1.5           |     P=0.776N     (e)          P=0.505      (e)         |P=0.217      P=0.501      P=0.242      P=0.230      |
|POLY 6             |     P=0.777N     (e)          P=0.504      (e)         |P=0.208      P=0.503      P=0.246      P=0.226      |
|LOGISTIC REGRESSION|     P=0.804      (e)          P=0.239      (e)         |(e)          P=0.511      P=0.232      P=0.232      |
|COCH-ARM / FISHERS |     P=0.779N     (e)          P=0.500      (e)         |P=0.228      P=0.500      P=0.247      P=0.247      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    2/20 (10%)   0/28 (0%)   |0/36 (0%)    0/38 (0%)    1/34 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.653N     (e)          P=0.198      (e)         |P=0.792N     (e)          P=0.489      (e)          |
|POLY 3             |     P=0.670N     (e)          P=0.239      (e)         |P=0.792N     (e)          P=0.502      (e)          |
|POLY 1.5           |     P=0.670N     (e)          P=0.240      (e)         |P=0.790N     (e)          P=0.500      (e)          |
|POLY 6             |     P=0.673N     (e)          P=0.235      (e)         |P=0.794N     (e)          P=0.503      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.198      (e)         |(e)          (e)          P=0.489      (e)          |
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |P=0.785N     (e)          P=0.495      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         5.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    2/20 (10%)   0/28 (0%)   |0/36 (0%)    0/38 (0%)    1/34 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.421N     P=0.455N     P=0.436      P=0.469N    |P=0.792N     (e)          P=0.489      (e)          |
|POLY 3             |     P=0.440N     P=0.482N     P=0.503      P=0.487N    |P=0.792N     (e)          P=0.502      (e)          |
|POLY 1.5           |     P=0.438N     P=0.488N     P=0.505      P=0.491N    |P=0.790N     (e)          P=0.500      (e)          |
|POLY 6             |     P=0.446N     P=0.476N     P=0.498      P=0.486N    |P=0.794N     (e)          P=0.503      (e)          |
|LOGISTIC REGRESSION|     P=0.421N     (e)          P=0.436      (e)         |(e)          (e)          P=0.489      (e)          |
|COCH-ARM / FISHERS |     P=0.441N     P=0.500N     P=0.500      P=0.500N    |P=0.785N     (e)          P=0.495      (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.7%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          677         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.049 *    (e)          (e)          P=0.267     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.042 *    (e)          (e)          P=0.252     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.042 *    (e)          (e)          P=0.248     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.255     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.044 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         0.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     633          ---          ---          701         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.663N     P=0.205N     P=0.263N     P=0.468N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.682N     P=0.219N     P=0.236N     P=0.480N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.678N     P=0.225N     P=0.235N     P=0.485N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.685N     P=0.214N     P=0.241N     P=0.479N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.668N     P=0.230N     P=0.235N     P=0.486N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.673N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         0.0%         7.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     633          ---          ---          677         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.163      P=0.205N     P=0.263N     P=0.547     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.145      P=0.219N     P=0.236N     P=0.528     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.146      P=0.225N     P=0.235N     P=0.521     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.142      P=0.214N     P=0.241N     P=0.532     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.154      P=0.230N     P=0.235N     P=0.524     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.148      P=0.247N     P=0.247N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         0.0%         7.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     633          ---          ---          677         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.163      P=0.205N     P=0.263N     P=0.547     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.145      P=0.219N     P=0.236N     P=0.528     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.146      P=0.225N     P=0.235N     P=0.521     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.142      P=0.214N     P=0.241N     P=0.532     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.154      P=0.230N     P=0.235N     P=0.524     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.148      P=0.247N     P=0.247N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         5.0%         2.4%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    1/20 (5%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    1/35 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     613          ---          725          729 (T)     |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.571N     P=0.210N     P=0.639      P=0.467N    |P=0.793N     (e)          P=0.494      (e)          |
|POLY 3             |     P=0.595N     P=0.220N     P=0.695      P=0.482N    |P=0.793N     (e)          P=0.506      (e)          |
|POLY 1.5           |     P=0.592N     P=0.225N     P=0.691N     P=0.485N    |P=0.791N     (e)          P=0.504      (e)          |
|POLY 6             |     P=0.602N     P=0.214N     P=0.687      P=0.481N    |P=0.794N     (e)          P=0.508      (e)          |
|LOGISTIC REGRESSION|     P=0.582N     P=0.236N     P=0.695N     P=0.484N    |(e)          (e)          P=0.494      (e)          |
|COCH-ARM / FISHERS |     P=0.592N     P=0.247N     P=0.691N     P=0.500N    |P=0.786N     (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         5.0%         4.7%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    1/20 (5%)    2/28 (7%)   |0/36 (0%)    0/38 (0%)    1/35 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     613          ---          725          729 (T)     |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.460      P=0.210N     P=0.639      P=0.655N    |P=0.793N     (e)          P=0.494      (e)          |
|POLY 3             |     P=0.435      P=0.220N     P=0.695      P=0.675N    |P=0.793N     (e)          P=0.506      (e)          |
|POLY 1.5           |     P=0.439      P=0.225N     P=0.691N     P=0.679N    |P=0.791N     (e)          P=0.504      (e)          |
|POLY 6             |     P=0.427      P=0.214N     P=0.687      P=0.676N    |P=0.794N     (e)          P=0.508      (e)          |
|LOGISTIC REGRESSION|     P=0.447      P=0.236N     P=0.695N     P=0.674N    |(e)          (e)          P=0.494      (e)          |
|COCH-ARM / FISHERS |     P=0.437      P=0.247N     P=0.691N     P=0.691N    |P=0.786N     (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.2%         2.2%         4.3%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    1/38 (3%)    1/35 (3%)    1/35 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |613          730 (T)      667          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.644      P=0.752N     P=0.513      P=0.752      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.638      P=0.761N     P=0.509      P=0.749      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.645      P=0.760      P=0.506      P=0.753      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.631      P=0.760N     P=0.512      P=0.746      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.641N     P=0.762      P=0.473      P=0.757N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.640N     P=0.753N     P=0.500      P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.4%        |4.5%         2.2%         4.3%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    1/28 (4%)   |1/36 (3%)    1/38 (3%)    1/35 (3%)    1/35 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |613          730 (T)      667          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.239      (e)          (e)          P=0.531     |P=0.500N     P=0.485N     P=0.685N     P=0.512N     |
|POLY 3             |     P=0.224      (e)          (e)          P=0.513     |P=0.499N     P=0.500N     P=0.684N     P=0.518N     |
|POLY 1.5           |     P=0.224      (e)          (e)          P=0.509     |P=0.493N     P=0.500N     P=0.687N     P=0.512N     |
|POLY 6             |     P=0.223      (e)          (e)          P=0.514     |P=0.504N     P=0.499N     P=0.682N     P=0.523N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.531     |P=0.485N     P=0.500N     P=0.683      P=0.503N     |
|COCH-ARM / FISHERS |     P=0.221      (e)          (e)          P=0.500     |P=0.479N     P=0.500N     P=0.691N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   3/50 (6%)    2/50 (4%)   |15/50 (30%)  20/50 (40%)  20/50 (40%)  8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     7.5%         13.8%        7.4%         4.7%        |33.0%        43.7%        42.8%        18.6%        |
|TERMINAL (d)       |     2/24 (8%)    5/30 (17%)   1/20 (5%)    2/28 (7%)   |11/36 (31%)  17/38 (45%)  15/35 (43%)  7/35 (20%)   |
|FIRST INCIDENCE    |     640          723          621          729 (T)     |613          633          536          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.207N     P=0.352      P=0.606      P=0.444N    |P=0.027N*    P=0.265      P=0.204      P=0.099N     |
|POLY 3             |     P=0.208N     P=0.282      P=0.658N     P=0.475N    |P=0.022N*    P=0.199      P=0.224      P=0.095N     |
|POLY 1.5           |     P=0.212N     P=0.269      P=0.656N     P=0.480N    |P=0.019N*    P=0.198      P=0.217      P=0.088N     |
|POLY 6             |     P=0.209N     P=0.296      P=0.664      P=0.474N    |P=0.025N*    P=0.202      P=0.227      P=0.102N     |
|LOGISTIC REGRESSION|     P=0.217N     P=0.316      P=0.661N     P=0.467N    |P=0.020N*    P=0.208      P=0.231      P=0.092N     |
|COCH-ARM / FISHERS |     P=0.228N     P=0.243      P=0.661N     P=0.500N    |P=0.015N*    P=0.201      P=0.201      P=0.077N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   3/50 (6%)    3/50 (6%)   |16/50 (32%)  20/50 (40%)  20/50 (40%)  8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     7.5%         13.8%        7.4%         7.1%        |35.2%        43.7%        42.8%        18.6%        |
|TERMINAL (d)       |     2/24 (8%)    5/30 (17%)   1/20 (5%)    3/28 (11%)  |12/36 (33%)  17/38 (45%)  15/35 (43%)  7/35 (20%)   |
|FIRST INCIDENCE    |     640          723          621          729 (T)     |613          633          536          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.357N     P=0.352      P=0.606      P=0.603N    |P=0.020N*    P=0.338      P=0.264      P=0.067N     |
|POLY 3             |     P=0.368N     P=0.282      P=0.658N     P=0.637N    |P=0.015N*    P=0.267      P=0.296      P=0.062N     |
|POLY 1.5           |     P=0.372N     P=0.269      P=0.656N     P=0.642N    |P=0.013N*    P=0.265      P=0.287      P=0.058N     |
|POLY 6             |     P=0.370N     P=0.296      P=0.664      P=0.637N    |P=0.018N*    P=0.271      P=0.300      P=0.068N     |
|LOGISTIC REGRESSION|     P=0.377N     P=0.316      P=0.661N     P=0.629N    |P=0.015N*    P=0.276      P=0.304      P=0.062N     |
|COCH-ARM / FISHERS |     P=0.392N     P=0.243      P=0.661N     P=0.661N    |P=0.011N*    P=0.266      P=0.266      P=0.050N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   3/50 (6%)    3/50 (6%)   |16/50 (32%)  21/50 (42%)  22/50 (44%)  8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     7.5%         13.8%        7.4%         7.1%        |35.2%        45.9%        46.8%        18.6%        |
|TERMINAL (d)       |     2/24 (8%)    5/30 (17%)   1/20 (5%)    3/28 (11%)  |12/36 (33%)  18/38 (47%)  16/35 (46%)  7/35 (20%)   |
|FIRST INCIDENCE    |     640          723          621          729 (T)     |613          633          536          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.357N     P=0.352      P=0.606      P=0.603N    |P=0.017N*    P=0.271      P=0.161      P=0.067N     |
|POLY 3             |     P=0.368N     P=0.282      P=0.658N     P=0.637N    |P=0.012N*    P=0.201      P=0.175      P=0.062N     |
|POLY 1.5           |     P=0.372N     P=0.269      P=0.656N     P=0.642N    |P=0.010N*    P=0.201      P=0.167      P=0.058N     |
|POLY 6             |     P=0.370N     P=0.296      P=0.664      P=0.637N    |P=0.014N*    P=0.204      P=0.182      P=0.068N     |
|LOGISTIC REGRESSION|     P=0.377N     P=0.316      P=0.661N     P=0.629N    |P=0.012N*    P=0.212      P=0.177      P=0.062N     |
|COCH-ARM / FISHERS |     P=0.392N     P=0.243      P=0.661N     P=0.661N    |P=0.008N**   P=0.204      P=0.151      P=0.050N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          680          ---          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.610      P=0.249      (e)          P=0.496      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.615      P=0.240      (e)          P=0.495      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.616      P=0.239      (e)          P=0.496      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.615      P=0.243      (e)          P=0.494      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.666      P=0.238      (e)          P=0.614      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.622      P=0.247      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         0.0%         0.0%         4.7%         |
|TERMINAL (d)       |                                                        |0/36 (0%)    0/38 (0%)    0/35 (0%)    2/35 (6%)    |
|FIRST INCIDENCE    |                                                        |---          ---          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.038 *    (e)          (e)          P=0.232      |
|POLY 3             |                                                        |P=0.038 *    (e)          (e)          P=0.228      |
|POLY 1.5           |                                                        |P=0.039 *    (e)          (e)          P=0.230      |
|POLY 6             |                                                        |P=0.038 *    (e)          (e)          P=0.226      |
|LOGISTIC REGRESSION|                                                        |(e)          (e)          (e)          P=0.232      |
|COCH-ARM / FISHERS |                                                        |P=0.042 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  13/50 (26%)  7/50 (14%)   11/50 (22%) |23/50 (46%)  13/49 (27%)  17/50 (34%)  8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     26.9%        29.5%        16.4%        25.4%       |49.6%        29.0%        35.4%        18.6%        |
|TERMINAL (d)       |     7/24 (29%)   8/30 (27%)   1/20 (5%)    8/28 (29%)  |16/36 (44%)  11/37 (30%)  10/35 (29%)  7/35 (20%)   |
|FIRST INCIDENCE    |     614          663          482          633         |575          540          468          631          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.449N     P=0.549N     P=0.281N     P=0.466N    |P=0.011N*    P=0.032N*    P=0.182N     P=0.003N**   |
|POLY 3             |     P=0.482N     P=0.491      P=0.182N     P=0.539N    |P=0.007N**   P=0.033N*    P=0.115N     P<0.001N**   |
|POLY 1.5           |     P=0.484N     P=0.464      P=0.190N     P=0.551N    |P=0.006N**   P=0.032N*    P=0.127N     P<0.001N**   |
|POLY 6             |     P=0.489N     P=0.520      P=0.178N     P=0.536N    |P=0.008N**   P=0.034N*    P=0.110N     P=0.002N**   |
|LOGISTIC REGRESSION|     P=0.482N     P=0.529      P=0.215N     P=0.528N    |P=0.005N**   P=0.034N*    P=0.152N     P=0.002N**   |
|COCH-ARM / FISHERS |     P=0.509N     P=0.408      P=0.218N     P=0.595N    |P=0.004N**   P=0.035N*    P=0.154N     P<0.001N**   |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         2.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     687          ---          549          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.267N     P=0.190N     P=0.513N     P=0.206N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.283N     P=0.218N     P=0.493N     P=0.224N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.280N     P=0.225N     P=0.493N     P=0.227N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.288N     P=0.212N     P=0.497N     P=0.223N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.283N     P=0.213N     P=0.503N     P=0.222N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.276N     P=0.247N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         2.3%         2.5%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     642          729 (T)      708          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.486N     P=0.436N     P=0.513N     P=0.463N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.498N     P=0.472N     P=0.499N     P=0.481N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.497N     P=0.481N     P=0.496N     P=0.485N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.502N     P=0.463N     P=0.506N     P=0.481N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.491N     P=0.473N     P=0.497N     P=0.480N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         2.3%         2.5%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     642          729 (T)      708          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.486N     P=0.436N     P=0.513N     P=0.463N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.498N     P=0.472N     P=0.499N     P=0.481N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.497N     P=0.481N     P=0.496N     P=0.485N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.502N     P=0.463N     P=0.506N     P=0.481N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.491N     P=0.473N     P=0.497N     P=0.480N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   3/50 (6%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     14.9%        13.8%        7.4%         9.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/24 (13%)   5/30 (17%)   1/20 (5%)    3/28 (11%)  |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     642          718          708          676         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.282N     P=0.476N     P=0.295N     P=0.297N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.294N     P=0.566N     P=0.239N     P=0.334N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.297N     P=0.584N     P=0.236N     P=0.342N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.296N     P=0.551N     P=0.249N     P=0.332N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.294N     P=0.522N     P=0.243N     P=0.324N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.311N     P=0.620N     P=0.243N     P=0.370N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         4.6%         2.5%         2.4%        |0.0%         4.4%         0.0%         0.0%         |
|TERMINAL (d)       |     2/24 (8%)    2/30 (7%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      691          729 (T)     |---          429          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.370N     P=0.613N     P=0.530N     P=0.446N    |P=0.379N     P=0.246      (e)          (e)          |
|POLY 3             |     P=0.387N     P=0.662N     P=0.495N     P=0.478N    |P=0.370N     P=0.243      (e)          (e)          |
|POLY 1.5           |     P=0.388N     P=0.673N     P=0.494N     P=0.483N    |P=0.370N     P=0.241      (e)          (e)          |
|POLY 6             |     P=0.388N     P=0.650N     P=0.499N     P=0.475N    |P=0.369N     P=0.246      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.385N     P=0.613N     P=0.507N     P=0.446N    |P=0.283N     P=0.237      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.395N     P=0.691N     P=0.500N     P=0.500N    |P=0.369N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.5%         4.6%         4.9%         4.7%        |2.2%         4.4%         2.2%         0.0%         |
|TERMINAL (d)       |     2/24 (8%)    2/30 (7%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     728          729 (T)      557          537         |665          429          703          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.467N     P=0.403N     P=0.545N     P=0.440N    |P=0.245N     P=0.512      P=0.741N     P=0.516N     |
|POLY 3             |     P=0.487N     P=0.459N     P=0.488N     P=0.465N    |P=0.244N     P=0.508      P=0.754N     P=0.509N     |
|POLY 1.5           |     P=0.489N     P=0.473N     P=0.489N     P=0.475N    |P=0.240N     P=0.505      P=0.756N     P=0.507N     |
|POLY 6             |     P=0.488N     P=0.444N     P=0.489N     P=0.457N    |P=0.247N     P=0.510      P=0.753N     P=0.512N     |
|LOGISTIC REGRESSION|     P=0.493N     P=0.416N     P=0.496N     P=0.479N    |P=0.187N     P=0.503      P=0.755      P=0.491N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.500N     P=0.500N    |P=0.231N     P=0.500      P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   2/50 (4%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.5%         11.5%        5.0%         9.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/24 (13%)   4/30 (13%)   1/20 (5%)    3/28 (11%)  |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     729 (T)      718          708          676         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.583      P=0.477      P=0.567N     P=0.582     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.569      P=0.406      P=0.495N     P=0.537     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.563      P=0.389      P=0.493N     P=0.527     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.572      P=0.426      P=0.501N     P=0.545     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.560      P=0.457      P=0.528N     P=0.549     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.542      P=0.357      P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   2/50 (4%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.0%        11.5%        5.0%         9.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/24 (13%)   4/30 (13%)   1/20 (5%)    3/28 (11%)  |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     682          718          708          676         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.512N     P=0.626      P=0.395N     P=0.566N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.535N     P=0.554      P=0.333N     P=0.609N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.538N     P=0.536      P=0.331N     P=0.617N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.534N     P=0.573      P=0.340N     P=0.605N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.539N     P=0.604      P=0.346N     P=0.601N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.555N     P=0.500      P=0.339N     P=0.643N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   2/50 (4%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.0%        11.5%        5.0%         9.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/24 (13%)   4/30 (13%)   1/20 (5%)    3/28 (11%)  |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     682          718          708          676         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.512N     P=0.626      P=0.395N     P=0.566N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.535N     P=0.554      P=0.333N     P=0.609N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.538N     P=0.536      P=0.331N     P=0.617N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.534N     P=0.573      P=0.340N     P=0.605N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.539N     P=0.604      P=0.346N     P=0.601N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.555N     P=0.500      P=0.339N     P=0.643N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     41/50 (82%)  46/50 (92%)  45/50 (90%)  49/50 (98%) |                                                    |
|POLY-3 ADJUSTED (b)|     91.5%        95.5%        94.7%        98.0%       |                                                    |
|TERMINAL (d)       |     22/24 (92%)  29/30 (97%)  19/20 (95%)  27/28 (96%) |                                                    |
|FIRST INCIDENCE    |     569          512          444          490         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.301      P=0.372N     P=0.146      P=0.384     |                                                    |
|POLY 3             |     P=0.148      P=0.345      P=0.415      P=0.143     |                                                    |
|POLY 1.5           |     P=0.066      P=0.234      P=0.339      P=0.050     |                                                    |
|POLY 6             |     P=0.265      P=0.441      P=0.432      P=0.273     |                                                    |
|LOGISTIC REGRESSION|     P=0.045 *    P=0.333      P=0.251      P=0.043 *   |                                                    |
|COCH-ARM / FISHERS |     P=0.018 *    P=0.117      P=0.194      P=0.008 **  |                                                    |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   7/50 (14%)   5/50 (10%)   8/50 (16%)  |5/50 (10%)   8/50 (16%)   6/50 (12%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     20.0%        15.8%        12.3%        18.3%       |11.2%        17.8%        13.1%        4.7%         |
|TERMINAL (d)       |     7/24 (29%)   6/30 (20%)   4/20 (20%)   5/28 (18%)  |4/36 (11%)   8/38 (21%)   6/35 (17%)   2/35 (6%)    |
|FIRST INCIDENCE    |     682          386          549          569         |701          730 (T)      730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.550      P=0.326N     P=0.378N     P=0.501N    |P=0.089N     P=0.308      P=0.487      P=0.229N     |
|POLY 3             |     P=0.526      P=0.412N     P=0.259N     P=0.532N    |P=0.091N     P=0.279      P=0.520      P=0.234N     |
|POLY 1.5           |     P=0.516      P=0.442N     P=0.261N     P=0.556N    |P=0.087N     P=0.278      P=0.513      P=0.229N     |
|POLY 6             |     P=0.536      P=0.384N     P=0.264N     P=0.510N    |P=0.094N     P=0.282      P=0.525      P=0.238N     |
|LOGISTIC REGRESSION|     P=0.512      P=0.424N     P=0.279N     P=0.554N    |P=0.089N     P=0.289      P=0.528      P=0.235N     |
|COCH-ARM / FISHERS |     P=0.490      P=0.500N     P=0.277N     P=0.607N    |P=0.078N     P=0.277      P=0.500      P=0.218N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         2.5%         4.7%        |4.5%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    0/20 (0%)    1/28 (4%)   |2/36 (6%)    0/38 (0%)    0/35 (0%)    1/35 (3%)    |
|FIRST INCIDENCE    |     ---          729 (T)      708          634         |730 (T)      ---          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.213      P=0.545      P=0.500      P=0.260     |P=0.664N     P=0.226N     P=0.244N     P=0.510N     |
|POLY 3             |     P=0.214      P=0.518      P=0.502      P=0.253     |P=0.656N     P=0.235N     P=0.230N     P=0.515N     |
|POLY 1.5           |     P=0.211      P=0.512      P=0.503      P=0.249     |P=0.654N     P=0.236N     P=0.233N     P=0.511N     |
|POLY 6             |     P=0.216      P=0.524      P=0.500      P=0.256     |P=0.658N     P=0.233N     P=0.228N     P=0.517N     |
|LOGISTIC REGRESSION|     P=0.207      P=0.545      P=0.499      P=0.242     |P=0.664N     (e)          (e)          P=0.510N     |
|COCH-ARM / FISHERS |     P=0.200      P=0.500      P=0.500      P=0.247     |P=0.650N     P=0.247N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   8/50 (16%)   6/50 (12%)   10/50 (20%) |7/50 (14%)   8/50 (16%)   6/50 (12%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     20.0%        18.1%        14.7%        22.7%       |15.7%        17.8%        13.1%        7.0%         |
|TERMINAL (d)       |     7/24 (29%)   7/30 (23%)   4/20 (20%)   6/28 (21%)  |6/36 (17%)   8/38 (21%)   6/35 (17%)   3/35 (9%)    |
|FIRST INCIDENCE    |     682          386          549          569         |701          730 (T)      730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.361      P=0.425N     P=0.500N     P=0.508     |P=0.096N     P=0.543      P=0.516N     P=0.170N     |
|POLY 3             |     P=0.345      P=0.519N     P=0.368N     P=0.486     |P=0.099N     P=0.506      P=0.478N     P=0.175N     |
|POLY 1.5           |     P=0.332      P=0.549N     P=0.369N     P=0.457     |P=0.094N     P=0.503      P=0.485N     P=0.170N     |
|POLY 6             |     P=0.360      P=0.489N     P=0.373N     P=0.516     |P=0.102N     P=0.510      P=0.472N     P=0.179N     |
|LOGISTIC REGRESSION|     P=0.323      P=0.526N     P=0.392N     P=0.453     |P=0.097N     P=0.522      P=0.471N     P=0.176N     |
|COCH-ARM / FISHERS |     P=0.302      P=0.607N     P=0.387N     P=0.398     |P=0.084N     P=0.500      P=0.500N     P=0.159N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.6%         0.0%         0.0%        |2.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          617          ---          ---         |723          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.390N     P=0.270      (e)          (e)         |P=0.485N     P=0.495N     P=0.500N     P=0.511N     |
|POLY 3             |     P=0.366N     P=0.260      (e)          (e)         |P=0.475N     P=0.498N     P=0.494N     P=0.509N     |
|POLY 1.5           |     P=0.375N     P=0.252      (e)          (e)         |P=0.475N     P=0.499N     P=0.496N     P=0.506N     |
|POLY 6             |     P=0.358N     P=0.269      (e)          (e)         |P=0.475N     P=0.497N     P=0.492N     P=0.510N     |
|LOGISTIC REGRESSION|     P=0.394N     P=0.233      (e)          (e)         |P=0.484N     P=0.496N     P=0.492N     P=0.510N     |
|COCH-ARM / FISHERS |     P=0.392N     P=0.247      (e)          (e)         |P=0.474N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          680          ---          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.610      P=0.249      (e)          P=0.496      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.615      P=0.240      (e)          P=0.495      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.616      P=0.239      (e)          P=0.496      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.615      P=0.243      (e)          P=0.494      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.666      P=0.238      (e)          P=0.614      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.622      P=0.247      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |10/50 (20%)  8/50 (16%)   5/50 (10%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |22.1%        17.3%        10.9%        11.6%        |
|TERMINAL (d)       |                                                        |8/36 (22%)   5/38 (13%)   5/35 (14%)   4/35 (11%)   |
|FIRST INCIDENCE    |                                                        |543          429          730 (T)      637          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.149N     P=0.361N     P=0.140N     P=0.150N     |
|POLY 3             |                                                        |P=0.145N     P=0.377N     P=0.121N     P=0.151N     |
|POLY 1.5           |                                                        |P=0.138N     P=0.386N     P=0.124N     P=0.145N     |
|POLY 6             |                                                        |P=0.152N     P=0.365N     P=0.120N     P=0.155N     |
|LOGISTIC REGRESSION|                                                        |P=0.131N     P=0.398N     P=0.116N     P=0.148N     |
|COCH-ARM / FISHERS |                                                        |P=0.121N     P=0.398N     P=0.131N     P=0.131N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.2%         0.0%         0.0%         4.7%         |
|TERMINAL (d)       |                                                        |0/36 (0%)    0/38 (0%)    0/35 (0%)    1/35 (3%)    |
|FIRST INCIDENCE    |                                                        |645          ---          ---          639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.167      P=0.495N     P=0.491N     P=0.471      |
|POLY 3             |                                                        |P=0.181      P=0.499N     P=0.495N     P=0.486      |
|POLY 1.5           |                                                        |P=0.184      P=0.500N     P=0.497N     P=0.490      |
|POLY 6             |                                                        |P=0.180      P=0.499N     P=0.494N     P=0.483      |
|LOGISTIC REGRESSION|                                                        |P=0.203      P=0.500N     P=0.532N     P=0.511      |
|COCH-ARM / FISHERS |                                                        |P=0.189      P=0.500N     P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |11/50 (22%)  8/50 (16%)   5/50 (10%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|                                                        |24.2%        17.3%        10.9%        13.9%        |
|TERMINAL (d)       |                                                        |8/36 (22%)   5/38 (13%)   5/35 (14%)   4/35 (11%)   |
|FIRST INCIDENCE    |                                                        |543          429          730 (T)      637          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.200N     P=0.277N     P=0.094N     P=0.175N     |
|POLY 3             |                                                        |P=0.188N     P=0.291N     P=0.080N     P=0.166N     |
|POLY 1.5           |                                                        |P=0.180N     P=0.297N     P=0.081N     P=0.159N     |
|POLY 6             |                                                        |P=0.194N     P=0.284N     P=0.080N     P=0.171N     |
|LOGISTIC REGRESSION|                                                        |P=0.168N     P=0.306N     P=0.077N     P=0.156N     |
|COCH-ARM / FISHERS |                                                        |P=0.161N     P=0.306N     P=0.086N     P=0.143N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     27/50 (54%)  22/50 (44%)  25/50 (50%)  27/50 (54%) |8/50 (16%)   7/50 (14%)   14/50 (28%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     57.2%        47.8%        55.7%        57.1%       |17.5%        15.4%        29.4%        30.7%        |
|TERMINAL (d)       |     8/24 (33%)   11/30 (37%)  6/20 (30%)   11/28 (39%) |5/36 (14%)   4/38 (11%)   7/35 (20%)   7/35 (20%)   |
|FIRST INCIDENCE    |     313          585          444          529         |501          659          575          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.458      P=0.108N     P=0.535N     P=0.413N    |P=0.049 *    P=0.470N     P=0.138      P=0.115      |
|POLY 3             |     P=0.389      P=0.239N     P=0.524N     P=0.579N    |P=0.050      P=0.505N     P=0.131      P=0.107      |
|POLY 1.5           |     P=0.385      P=0.223N     P=0.474N     P=0.569N    |P=0.051      P=0.505N     P=0.123      P=0.107      |
|POLY 6             |     P=0.385      P=0.260N     P=0.583N     P=0.569     |P=0.053      P=0.501N     P=0.143      P=0.111      |
|LOGISTIC REGRESSION|     P=0.342      P=0.248N     P=0.434N     P=0.503     |P=0.067      P=0.502N     P=0.098      P=0.136      |
|COCH-ARM / FISHERS |     P=0.359      P=0.212N     P=0.421N     P=0.579N    |P=0.055      P=0.500N     P=0.114      P=0.114      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    5/50 (10%)   6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         4.5%         12.3%        13.7%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    3/20 (15%)   2/28 (7%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     687          585          537          569         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.095      P=0.637N     P=0.176      P=0.177     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.086      P=0.655N     P=0.222      P=0.165     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.083      P=0.669N     P=0.224      P=0.155     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.087      P=0.639N     P=0.217      P=0.175     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.068      P=0.670      P=0.218      P=0.125     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.074      P=0.691N     P=0.218      P=0.134     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 24
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    5/50 (10%)   6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         4.5%         12.3%        13.7%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    3/20 (15%)   2/28 (7%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     687          585          537          569         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.095      P=0.637N     P=0.176      P=0.177     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.086      P=0.655N     P=0.222      P=0.165     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.083      P=0.669N     P=0.224      P=0.155     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.087      P=0.639N     P=0.217      P=0.175     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.068      P=0.670      P=0.218      P=0.125     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.074      P=0.691N     P=0.218      P=0.134     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  48/50 (96%)  47/50 (94%)  50/50 (100%)|37/50 (74%)  35/50 (70%)  35/50 (70%)  20/50 (40%)  |
|POLY-3 ADJUSTED (b)|     93.8%        97.6%        97.5%        100.0%      |77.1%        73.3%        71.8%        45.8%        |
|TERMINAL (d)       |     23/24 (96%)  29/30 (97%)  20/20 (100%) 28/28 (100%)|27/36 (75%)  28/38 (74%)  25/35 (71%)  17/35 (49%)  |
|FIRST INCIDENCE    |     569          386          444          490         |429          429          468          631          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.337      P=0.418N     P=0.109      P=0.391     |P=0.002N**   P=0.314N     P=0.447N     P=0.003N**   |
|POLY 3             |     P=0.081      P=0.319      P=0.315      P=0.073     |P<0.001N**   P=0.421N     P=0.357N     P<0.001N**   |
|POLY 1.5           |     P=0.033 *    P=0.152      P=0.212      P=0.017 *   |P<0.001N**   P=0.418N     P=0.371N     P<0.001N**   |
|POLY 6             |     P=0.168      P=0.506      P=0.377      P=0.205     |P<0.001N**   P=0.426N     P=0.359N     P=0.002N**   |
|LOGISTIC REGRESSION|     P=0.036 *    P=0.147      P=0.130      P=0.026 *   |P<0.001N**   P=0.405N     P=0.391N     P<0.001N**   |
|COCH-ARM / FISHERS |     P=0.011 *    P=0.046 *    P=0.100      P=0.003 **  |P<0.001N**   P=0.412N     P=0.412N     P<0.001N**   |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 25
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     34/50 (68%)  33/50 (66%)  37/50 (74%)  36/50 (72%) |15/50 (30%)  14/50 (28%)  20/50 (40%)  25/50 (50%)  |
|POLY-3 ADJUSTED (b)|     69.1%        66.2%        75.5%        73.0%       |31.5%        29.9%        41.8%        52.4%        |
|TERMINAL (d)       |     10/24 (42%)  15/30 (50%)  11/20 (55%)  15/28 (54%) |8/36 (22%)   8/38 (21%)   11/35 (31%)  14/35 (40%)  |
|FIRST INCIDENCE    |     312          386          400          529         |414          429          575          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.489      P=0.238N     P=0.291      P=0.481N    |P=0.012 *    P=0.456N     P=0.242      P=0.046 *    |
|POLY 3             |     P=0.326      P=0.461N     P=0.315      P=0.419     |P=0.009 **   P=0.523N     P=0.201      P=0.029 *    |
|POLY 1.5           |     P=0.328      P=0.478N     P=0.320      P=0.413     |P=0.009 **   P=0.516N     P=0.200      P=0.029 *    |
|POLY 6             |     P=0.333      P=0.439N     P=0.312      P=0.435     |P=0.010 *    P=0.525N     P=0.207      P=0.030 *    |
|LOGISTIC REGRESSION|     P=0.301      P=0.442      P=0.330      P=0.315     |P=0.015 *    P=0.508N     P=0.165      P=0.045 *    |
|COCH-ARM / FISHERS |     P=0.339      P=0.500N     P=0.330      P=0.414     |P=0.010 *    P=0.500N     P=0.201      P=0.033 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     49/50 (98%)  50/50 (100%) 50/50 (100%) 50/50 (100%)|42/50 (84%)  40/50 (80%)  42/50 (84%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     98.0%        100.0%       100.0%       100.0%      |84.9%        83.1%        84.0%        75.5%        |
|TERMINAL (d)       |     23/24 (96%)  30/30 (100%) 20/20 (100%) 28/28 (100%)|30/36 (83%)  31/38 (82%)  27/35 (77%)  25/35 (71%)  |
|FIRST INCIDENCE    |     312          386          400          490         |414          429          468          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.408N     P=0.166N     P=0.284      P=0.313N    |P=0.304N     P=0.306N     P=0.554      P=0.271N     |
|POLY 3             |     P=0.500      P=0.500      P=0.500      P=0.500     |P=0.129N     P=0.517N     P=0.562N     P=0.177N     |
|POLY 1.5           |     P=0.500      P=0.500      P=0.500      P=0.500     |P=0.111N     P=0.480N     P=0.583N     P=0.152N     |
|POLY 6             |     P=0.500      P=0.500      P=0.500      P=0.500     |P=0.147N     P=0.535N     P=0.530N     P=0.198N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.092N     P=0.394N     P=0.574      P=0.112N     |
|COCH-ARM / FISHERS |     P=0.500      P=0.500      P=0.500      P=0.500     |P=0.087N     P=0.398N     P=0.607N     P=0.114N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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