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TDMS Study 88120-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 10/27/99       
EXPERIMENT: 88120 TEST: 03                                                                                     TIME: 13:00:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B       
PATHOLOGIST: SINGER, ALLEN                                                                                     CAS: 80-07-9         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                      FINAL #1 CORE STUDY RATS                                                      
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 10/27/99     
EXPERIMENT: 88120 TEST: 03                                                                                     TIME: 13:00:41     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B     
PATHOLOGIST: SINGER, ALLEN                                                                                     CAS: 80-07-9       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF           P,P'-DICHLORODIPHENYL SULFONE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Heart                                  Cardiomyopathy
Kidney                                 Nephropathy
                                       Pigmentation
Liver                                  Mixed Cell Focus
                                       Vacuolization Cytoplasmic
Liver: Centrilobular                   Hypertrophy
Lung: Alveolar Epithelium              Hyperplasia
Lymph Node, Mandibular                 Hyperplasia
Mammary Gland                          Galactocele
                                       Hyperplasia
Pituitary Gland                        Cyst
Pituitary Gland: Pars Distalis         Pseudocyst
Prostate                               Inflammation
Testes: Interstitial Cell              Hyperplasia
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Hyperplasia
Heart                                  Inflammation
Kidney                                 Pigmentation
Liver                                  Basophilic Focus
                                       Inflammation
                                       Mixed Cell Focus
Liver: Bile Duct                       Hyperplasia
Liver: Centrilobular                   Degeneration
                                       Hypertrophy
Lung                                   Inflammation
                                       Necrosis
Lymph Node, Mandibular                 Ectasia
                                       Hyperplasia
Skin                                   Ulcer
Spleen                                 Pigmentation
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 1

Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |27/50 (54%)  21/50 (42%)  26/50 (52%)  26/50 (52%)  |
|POLY-3 ADJUSTED (b)|     5.0%         2.3%         5.0%         2.4%        |59.3%        46.2%        55.7%        60.5%        |
|TERMINAL (d)       |     2/24 (8%)    0/30 (0%)    1/20 (5%)    1/28 (4%)   |24/36 (67%)  19/38 (50%)  23/35 (66%)  25/35 (71%)  |
|FIRST INCIDENCE    |     729 (T)      687          691          729 (T)     |575          633          536          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.452N     P=0.420N     P=0.654      P=0.446N    |P=0.286      P=0.098N     P=0.543N     P=0.576N     |
|POLY 3             |     P=0.475N     P=0.468N     P=0.690N     P=0.478N    |P=0.275      P=0.143N     P=0.444N     P=0.541      |
|POLY 1.5           |     P=0.474N     P=0.479N     P=0.688N     P=0.483N    |P=0.321      P=0.149N     P=0.462N     P=0.582      |
|POLY 6             |     P=0.481N     P=0.455N     P=0.695N     P=0.475N    |P=0.232      P=0.135N     P=0.435N     P=0.499      |
|LOGISTIC REGRESSION|     P=0.469N     P=0.453N     P=0.687      P=0.446N    |P=0.267      P=0.127N     P=0.410N     P=0.553      |
|COCH-ARM / FISHERS |     P=0.479N     P=0.500N     P=0.691N     P=0.500N    |P=0.414      P=0.158N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         2.3%        |6.6%         2.2%         4.3%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |2/36 (6%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     361          ---          ---          677         |429          730 (T)      625          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.542      P=0.492N     P=0.492N     P=0.746N    |P=0.143N     P=0.292N     P=0.491N     P=0.129N     |
|POLY 3             |     P=0.533      P=0.487N     P=0.503N     P=0.751N    |P=0.143N     P=0.308N     P=0.488N     P=0.130N     |
|POLY 1.5           |     P=0.535      P=0.491N     P=0.500N     P=0.753N    |P=0.140N     P=0.308N     P=0.493N     P=0.126N     |
|POLY 6             |     P=0.530      P=0.481N     P=0.507N     P=0.749N    |P=0.146N     P=0.307N     P=0.482N     P=0.132N     |
|LOGISTIC REGRESSION|     P=0.374      P=0.836N     P=0.882N     P=0.609     |P=0.109N     P=0.305N     P=0.580N     P=0.093N     |
|COCH-ARM / FISHERS |     P=0.536      P=0.500N     P=0.500N     P=0.753N    |P=0.132N     P=0.309N     P=0.500N     P=0.121N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 2

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  13/50 (26%)  8/50 (16%)   9/50 (18%)  |14/50 (28%)  11/50 (22%)  19/50 (38%)  18/50 (36%)  |
|POLY-3 ADJUSTED (b)|     26.8%        29.3%        19.4%        20.7%       |30.8%        24.4%        40.8%        40.8%        |
|TERMINAL (d)       |     8/24 (33%)   10/30 (33%)  3/20 (15%)   6/28 (21%)  |11/36 (31%)  10/38 (26%)  14/35 (40%)  15/35 (43%)  |
|FIRST INCIDENCE    |     361          512          537          490         |613          680          662          414          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.228N     P=0.557N     P=0.405N     P=0.281N    |P=0.093      P=0.276N     P=0.205      P=0.227      |
|POLY 3             |     P=0.246N     P=0.493      P=0.296N     P=0.343N    |P=0.099      P=0.327N     P=0.217      P=0.220      |
|POLY 1.5           |     P=0.254N     P=0.462      P=0.295N     P=0.359N    |P=0.108      P=0.325N     P=0.210      P=0.232      |
|POLY 6             |     P=0.243N     P=0.527      P=0.302N     P=0.332N    |P=0.093      P=0.331N     P=0.222      P=0.209      |
|LOGISTIC REGRESSION|     P=0.256N     P=0.493      P=0.296N     P=0.358N    |P=0.089      P=0.306N     P=0.228      P=0.221      |
|COCH-ARM / FISHERS |     P=0.280N     P=0.408      P=0.306N     P=0.402N    |P=0.129      P=0.322N     P=0.198      P=0.260      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    7/50 (14%)   3/50 (6%)    2/50 (4%)   |4/50 (8%)    4/50 (8%)    5/50 (10%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     7.4%         15.9%        7.5%         4.7%        |8.9%         8.9%         10.7%        7.0%         |
|TERMINAL (d)       |     0/24 (0%)    5/30 (17%)   2/20 (10%)   2/28 (7%)   |3/36 (8%)    4/38 (11%)   3/35 (9%)    3/35 (9%)    |
|FIRST INCIDENCE    |     617          592          712          729 (T)     |660          730 (T)      575          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.175N     P=0.245      P=0.605      P=0.459N    |P=0.448N     P=0.615N     P=0.504      P=0.521N     |
|POLY 3             |     P=0.167N     P=0.193      P=0.661      P=0.478N    |P=0.446N     P=0.641N     P=0.526      P=0.526N     |
|POLY 1.5           |     P=0.170N     P=0.181      P=0.659N     P=0.482N    |P=0.436N     P=0.642N     P=0.516      P=0.518N     |
|POLY 6             |     P=0.169N     P=0.205      P=0.650      P=0.480N    |P=0.455N     P=0.640N     P=0.535      P=0.533N     |
|LOGISTIC REGRESSION|     P=0.175N     P=0.186      P=0.662N     P=0.475N    |P=0.439N     P=0.635N     P=0.498      P=0.527N     |
|COCH-ARM / FISHERS |     P=0.186N     P=0.159      P=0.661N     P=0.500N    |P=0.412N     P=0.643N     P=0.500      P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 3

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.2%         4.6%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     454          ---          ---          ---         |---          ---          714          531          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.254N     P=0.211N     P=0.255N     P=0.214N    |P=0.074      (e)          P=0.505      P=0.227      |
|POLY 3             |     P=0.270N     P=0.222N     P=0.239N     P=0.227N    |P=0.080      (e)          P=0.507      P=0.232      |
|POLY 1.5           |     P=0.267N     P=0.227N     P=0.236N     P=0.229N    |P=0.081      (e)          P=0.504      P=0.233      |
|POLY 6             |     P=0.274N     P=0.216N     P=0.244N     P=0.226N    |P=0.080      (e)          P=0.509      P=0.233      |
|LOGISTIC REGRESSION|     P=0.300N     P=0.290N     P=0.262N     P=0.297N    |P=0.112      (e)          P=0.506      P=0.283      |
|COCH-ARM / FISHERS |     P=0.262N     P=0.247N     P=0.247N     P=0.247N    |P=0.084      (e)          P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   6/50 (12%)   4/50 (8%)    3/50 (6%)   |3/50 (6%)    6/50 (12%)   5/50 (10%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     19.4%        13.7%        9.6%         7.1%        |6.7%         13.0%        10.8%        2.3%         |
|TERMINAL (d)       |     3/24 (13%)   4/30 (13%)   1/20 (5%)    2/28 (7%)   |2/36 (6%)    2/38 (5%)    2/35 (6%)    1/35 (3%)    |
|FIRST INCIDENCE    |     361          659          557          701         |723          616          575          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.093N     P=0.258N     P=0.231N     P=0.078N    |P=0.134N     P=0.277      P=0.354      P=0.319N     |
|POLY 3             |     P=0.094N     P=0.336N     P=0.170N     P=0.086N    |P=0.128N     P=0.259      P=0.380      P=0.321N     |
|POLY 1.5           |     P=0.093N     P=0.354N     P=0.170N     P=0.089N    |P=0.122N     P=0.251      P=0.371      P=0.316N     |
|POLY 6             |     P=0.097N     P=0.317N     P=0.172N     P=0.086N    |P=0.133N     P=0.273      P=0.389      P=0.323N     |
|LOGISTIC REGRESSION|     P=0.094N     P=0.360N     P=0.182N     P=0.092N    |P=0.112N     P=0.242      P=0.366      P=0.321N     |
|COCH-ARM / FISHERS |     P=0.097N     P=0.387N     P=0.178N     P=0.100N    |P=0.111N     P=0.243      P=0.357      P=0.309N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 4

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.4%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    2/35 (6%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.708N     (e)          P=0.232      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.712N     (e)          P=0.244      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.707N     (e)          P=0.242      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.716N     (e)          P=0.246      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.232      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.695N     (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  15/50 (30%)  12/50 (24%) |4/50 (8%)    8/49 (16%)   3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     34.5%        22.9%        36.2%        27.3%       |9.0%         17.9%        6.4%         2.3%         |
|TERMINAL (d)       |     8/24 (33%)   8/30 (27%)   5/20 (25%)   7/28 (25%)  |3/36 (8%)    6/38 (16%)   1/35 (3%)    1/35 (3%)    |
|FIRST INCIDENCE    |     614          708          557          569         |694          652          575          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.432N     P=0.108N     P=0.362      P=0.291N    |P=0.051N     P=0.204      P=0.500N     P=0.191N     |
|POLY 3             |     P=0.437N     P=0.172N     P=0.528      P=0.314N    |P=0.045N*    P=0.177      P=0.474N     P=0.192N     |
|POLY 1.5           |     P=0.454N     P=0.194N     P=0.527      P=0.342N    |P=0.043N*    P=0.172      P=0.484N     P=0.188N     |
|POLY 6             |     P=0.424N     P=0.154N     P=0.521      P=0.292N    |P=0.046N*    P=0.184      P=0.464N     P=0.195N     |
|LOGISTIC REGRESSION|     P=0.467N     P=0.122N     P=0.492      P=0.334N    |P=0.042N*    P=0.176      P=0.516N     P=0.194N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.241N     P=0.500      P=0.410N    |P=0.040N*    P=0.168      P=0.500N     P=0.181N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 5

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    6/50 (12%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.3%         0.0%         2.4%        |4.4%         4.4%         13.1%        9.4%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |1/36 (3%)    1/38 (3%)    4/35 (11%)   4/35 (11%)   |
|FIRST INCIDENCE    |     512          659          ---          722         |575          666          723          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.683      P=0.729N     P=0.496N     P=0.735N    |P=0.246      P=0.676N     P=0.135      P=0.324      |
|POLY 3             |     P=0.676      P=0.743N     P=0.501N     P=0.750N    |P=0.236      P=0.693N     P=0.139      P=0.312      |
|POLY 1.5           |     P=0.676      P=0.749N     P=0.499N     P=0.752N    |P=0.248      P=0.693N     P=0.138      P=0.320      |
|POLY 6             |     P=0.674      P=0.736N     P=0.506N     P=0.750N    |P=0.226      P=0.691N     P=0.140      P=0.306      |
|LOGISTIC REGRESSION|     P=0.648      P=0.705      P=0.588N     P=0.727     |P=0.246      P=0.694      P=0.140      P=0.322      |
|COCH-ARM / FISHERS |     P=0.673      P=0.753N     P=0.500N     P=0.753N    |P=0.273      P=0.691N     P=0.134      P=0.339      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  18/50 (36%)  16/50 (32%)  20/50 (40%) |9/50 (18%)   12/50 (24%)  8/50 (16%)   12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     41.4%        39.5%        37.6%        44.3%       |19.4%        25.1%        17.3%        27.1%        |
|TERMINAL (d)       |     8/24 (33%)   11/30 (37%)  8/20 (40%)   13/28 (46%) |4/36 (11%)   7/38 (18%)   6/35 (17%)   7/35 (20%)   |
|FIRST INCIDENCE    |     361          585          523          537         |429          403          662          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.435      P=0.350N     P=0.540N     P=0.569N    |P=0.307      P=0.351      P=0.495N     P=0.292      |
|POLY 3             |     P=0.373      P=0.514N     P=0.445N     P=0.474     |P=0.294      P=0.337      P=0.504N     P=0.267      |
|POLY 1.5           |     P=0.371      P=0.538N     P=0.425N     P=0.462     |P=0.309      P=0.329      P=0.501N     P=0.279      |
|POLY 6             |     P=0.362      P=0.486N     P=0.475N     P=0.476     |P=0.288      P=0.343      P=0.508N     P=0.264      |
|LOGISTIC REGRESSION|     P=0.362      P=0.571N     P=0.409N     P=0.425     |P=0.407      P=0.292      P=0.528N     P=0.327      |
|COCH-ARM / FISHERS |     P=0.346      P=0.582N     P=0.417N     P=0.418     |P=0.353      P=0.312      P=0.500N     P=0.312      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 6

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         0.0%        |0.0%         0.0%         4.4%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    2/35 (6%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.761N     (e)          P=0.464      (e)         |P=0.708N     (e)          P=0.232      (e)          |
|POLY 3             |     P=0.776N     (e)          P=0.502      (e)         |P=0.713N     (e)          P=0.244      (e)          |
|POLY 1.5           |     P=0.776N     (e)          P=0.503      (e)         |P=0.709N     (e)          P=0.242      (e)          |
|POLY 6             |     P=0.777N     (e)          P=0.499      (e)         |P=0.717N     (e)          P=0.246      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.464      (e)         |(e)          (e)          P=0.232      (e)          |
|COCH-ARM / FISHERS |     P=0.779N     (e)          P=0.500      (e)         |P=0.697N     (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Myelofibrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.7%         4.6%         2.5%         4.6%        |2.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |1/36 (3%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     512          687          708          529         |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.385N     P=0.284N     P=0.199N     P=0.312N    |P=0.482N     P=0.489N     P=0.506N     P=0.506N     |
|POLY 3             |     P=0.391N     P=0.311N     P=0.185N     P=0.316N    |P=0.475N     P=0.498N     P=0.494N     P=0.508N     |
|POLY 1.5           |     P=0.391N     P=0.318N     P=0.180N     P=0.320N    |P=0.475N     P=0.499N     P=0.496N     P=0.506N     |
|POLY 6             |     P=0.393N     P=0.304N     P=0.196N     P=0.316N    |P=0.476N     P=0.497N     P=0.492N     P=0.510N     |
|LOGISTIC REGRESSION|     P=0.431N     P=0.375N     P=0.189N     P=0.438N    |P=0.482N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.397N     P=0.339N     P=0.181N     P=0.339N    |P=0.474N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 7

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    3/50 (6%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         2.3%         9.7%         6.9%        |4.4%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |1/36 (3%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     368          617          562          633         |543          ---          725          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.361      P=0.470N     P=0.329      P=0.527     |P=0.283N     P=0.236N     P=0.503N     P=0.250N     |
|POLY 3             |     P=0.365      P=0.476N     P=0.339      P=0.524     |P=0.280N     P=0.238N     P=0.494N     P=0.250N     |
|POLY 1.5           |     P=0.364      P=0.484N     P=0.341      P=0.518     |P=0.277N     P=0.238N     P=0.496N     P=0.246N     |
|POLY 6             |     P=0.363      P=0.467N     P=0.335      P=0.530     |P=0.283N     P=0.237N     P=0.492N     P=0.253N     |
|LOGISTIC REGRESSION|     P=0.276      P=0.663N     P=0.287      P=0.356     |P=0.254N     P=0.236N     P=0.531N     P=0.208N     |
|COCH-ARM / FISHERS |     P=0.354      P=0.500N     P=0.339      P=0.500     |P=0.271N     P=0.247N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    4/50 (8%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         9.9%         0.0%        |0.0%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     648          ---          712          ---         |---          ---          ---          639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.398N     P=0.463N     P=0.153      P=0.483N    |P=0.195      (e)          (e)          P=0.481      |
|POLY 3             |     P=0.402N     P=0.484N     P=0.179      P=0.489N    |P=0.208      (e)          (e)          P=0.493      |
|POLY 1.5           |     P=0.400N     P=0.489N     P=0.182      P=0.491N    |P=0.210      (e)          (e)          P=0.495      |
|POLY 6             |     P=0.410N     P=0.478N     P=0.172      P=0.488N    |P=0.207      (e)          (e)          P=0.493      |
|LOGISTIC REGRESSION|     P=0.400N     P=0.516N     P=0.177      P=0.515N    |P=0.241      (e)          (e)          P=0.522      |
|COCH-ARM / FISHERS |     P=0.408N     P=0.500N     P=0.181      P=0.500N    |P=0.214      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 8

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |6/47 (13%)   6/50 (12%)   6/50 (12%)   3/48 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |14.0%        13.3%        13.0%        7.3%         |
|TERMINAL (d)       |                                                        |6/36 (17%)   5/38 (13%)   5/35 (14%)   3/34 (9%)    |
|FIRST INCIDENCE    |                                                        |730 (T)      659          687          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.211N     P=0.583N     P=0.608      P=0.268N     |
|POLY 3             |                                                        |P=0.207N     P=0.585N     P=0.571N     P=0.265N     |
|POLY 1.5           |                                                        |P=0.197N     P=0.583N     P=0.572N     P=0.254N     |
|POLY 6             |                                                        |P=0.216N     P=0.586N     P=0.572N     P=0.273N     |
|LOGISTIC REGRESSION|                                                        |P=0.211N     P=0.596N     P=0.586N     P=0.268N     |
|COCH-ARM / FISHERS |                                                        |P=0.174N     P=0.576N     P=0.576N     P=0.232N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |16/47 (34%)  17/50 (34%)  21/50 (42%)  18/48 (38%)  |
|POLY-3 ADJUSTED (b)|                                                        |36.5%        36.5%        45.3%        42.3%        |
|TERMINAL (d)       |                                                        |13/36 (36%)  12/38 (32%)  18/35 (51%)  16/34 (47%)  |
|FIRST INCIDENCE    |                                                        |543          540          662          347          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.295      P=0.562      P=0.193      P=0.341      |
|POLY 3             |                                                        |P=0.310      P=0.585      P=0.261      P=0.367      |
|POLY 1.5           |                                                        |P=0.344      P=0.582      P=0.269      P=0.395      |
|POLY 6             |                                                        |P=0.271      P=0.580N     P=0.249      P=0.336      |
|LOGISTIC REGRESSION|                                                        |P=0.327      P=0.575      P=0.276      P=0.386      |
|COCH-ARM / FISHERS |                                                        |P=0.402      P=0.583N     P=0.275      P=0.445      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 9

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland: Duct                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/47 (6%)    5/50 (10%)   2/50 (4%)    3/48 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |7.0%         10.9%        4.4%         7.3%         |
|TERMINAL (d)       |                                                        |3/36 (8%)    2/38 (5%)    2/35 (6%)    2/34 (6%)    |
|FIRST INCIDENCE    |                                                        |730 (T)      451          730 (T)      614          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.496N     P=0.381      P=0.513N     P=0.638      |
|POLY 3             |                                                        |P=0.488N     P=0.396      P=0.470N     P=0.645      |
|POLY 1.5           |                                                        |P=0.479N     P=0.393      P=0.470N     P=0.653      |
|POLY 6             |                                                        |P=0.494N     P=0.400      P=0.471N     P=0.641      |
|LOGISTIC REGRESSION|                                                        |P=0.447N     P=0.403      P=0.513N     P=0.646      |
|COCH-ARM / FISHERS |                                                        |P=0.457N     P=0.393      P=0.470N     P=0.651N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     1/1 (100%)   1/1 (100%)  |1/3 (33%)    2/2 (100%)   0/0 (0%)     3/4 (75%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         100.0%       100.0%      |37.2%        100.0%       0.0%         75.0%        |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)    |1/2 (50%)    2/2 (100%)   0/0 (0%)     3/4 (75%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      585         |730 (T)      730 (T)      ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.237      (e)          P=1.000N     P=0.520     |P=0.675      P=0.500      P=1.000N     P=0.610      |
|POLY 3             |     (e)          (e)          P=1.000N     P=1.000N    |(e)          P=0.321      (e)          P=0.436      |
|POLY 1.5           |     (e)          (e)          P=1.000N     P=1.000N    |(e)          P=0.300      (e)          P=0.409      |
|POLY 6             |     (e)          (e)          P=1.000N     P=1.000N    |(e)          P=0.363      (e)          P=0.482      |
|LOGISTIC REGRESSION|     P=0.887      (e)          P=1.000N     (e)         |P=0.675      P=0.500      (e)          P=0.610      |
|COCH-ARM / FISHERS |     P=0.404      (e)          P=0.500      P=0.500     |P=0.461      P=0.300      P=1.000      P=0.371      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 10

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     1/1 (100%)   1/1 (100%)  |1/3 (33%)    2/2 (100%)   0/0 (0%)     3/4 (75%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         100.0%       100.0%      |37.2%        100.0%       0.0%         75.0%        |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)    |1/2 (50%)    2/2 (100%)   0/0 (0%)     3/4 (75%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      585         |730 (T)      730 (T)      ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.237      (e)          P=1.000      P=0.520     |P=0.675      P=0.500      P=1.000N     P=0.610      |
|POLY 3             |     (e)          (e)          P=1.000      P=1.000     |(e)          P=0.321      (e)          P=0.436      |
|POLY 1.5           |     (e)          (e)          P=1.000      P=1.000     |(e)          P=0.300      (e)          P=0.409      |
|POLY 6             |     (e)          (e)          P=1.000      P=1.000     |(e)          P=0.363      (e)          P=0.482      |
|LOGISTIC REGRESSION|     P=0.887      (e)          P=1.000      (e)         |P=0.675      P=0.500      (e)          P=0.610      |
|COCH-ARM / FISHERS |     P=0.404      (e)          P=0.500      P=0.500     |P=0.461      P=0.300      P=1.000      P=0.371      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     39/50 (78%)  46/50 (92%)  43/50 (86%)  43/50 (86%) |30/50 (60%)  23/50 (46%)  23/50 (46%)  27/50 (54%)  |
|POLY-3 ADJUSTED (b)|     87.6%        94.4%        91.4%        90.4%       |65.5%        50.8%        48.8%        60.1%        |
|TERMINAL (d)       |     23/24 (96%)  29/30 (97%)  20/20 (100%) 27/28 (96%) |26/36 (72%)  21/38 (55%)  20/35 (57%)  20/35 (57%)  |
|FIRST INCIDENCE    |     312          386          482          490         |575          666          536          531          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.442N     P=0.506N     P=0.123      P=0.506N    |P=0.420      P=0.064N     P=0.130N     P=0.417N     |
|POLY 3             |     P=0.570N     P=0.181      P=0.383      P=0.451     |P=0.507      P=0.106N     P=0.073N     P=0.372N     |
|POLY 1.5           |     P=0.591      P=0.104      P=0.316      P=0.368     |P=0.506      P=0.108N     P=0.086N     P=0.373N     |
|POLY 6             |     P=0.618      P=0.304      P=0.450      P=0.496     |P=0.530      P=0.102N     P=0.063N     P=0.349N     |
|LOGISTIC REGRESSION|     P=0.519N     P=0.123      P=0.271      P=0.444     |P=0.419      P=0.082N     P=0.077N     P=0.433N     |
|COCH-ARM / FISHERS |     P=0.439      P=0.045 *    P=0.218      P=0.218     |P=0.540      P=0.115N     P=0.115N     P=0.343N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 11

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |5/50 (10%)   4/50 (8%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         0.0%        |11.2%        8.7%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |5/36 (14%)   2/38 (5%)    0/35 (0%)    1/35 (3%)    |
|FIRST INCIDENCE    |     682          ---          ---          ---         |730 (T)      540          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.500N     P=0.471N     P=0.500N     P=0.488N    |P=0.070N     P=0.471N     P=0.035N*    P=0.108N     |
|POLY 3             |     P=0.511N     P=0.483N     P=0.499N     P=0.488N    |P=0.065N     P=0.481N     P=0.028N*    P=0.111N     |
|POLY 1.5           |     P=0.508N     P=0.489N     P=0.498N     P=0.491N    |P=0.064N     P=0.490N     P=0.029N*    P=0.108N     |
|POLY 6             |     P=0.514N     P=0.477N     P=0.503N     P=0.488N    |P=0.067N     P=0.469N     P=0.027N*    P=0.112N     |
|LOGISTIC REGRESSION|     P=0.498N     P=0.495N     P=0.498N     P=0.494N    |P=0.063N     P=0.499N     (e)          P=0.108N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.500N     P=0.500N    |P=0.062N     P=0.500N     P=0.028N*    P=0.102N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   5/50 (10%)   2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         11.4%        12.4%        4.7%        |0.0%         2.2%         2.2%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     674          663          708          701         |---          659          662          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.421N     P=0.153      P=0.090      P=0.538     |P=0.560N     P=0.510      P=0.523      (e)          |
|POLY 3             |     P=0.410N     P=0.124      P=0.102      P=0.521     |P=0.547N     P=0.503      P=0.507      (e)          |
|POLY 1.5           |     P=0.416N     P=0.116      P=0.104      P=0.516     |P=0.544N     P=0.502      P=0.505      (e)          |
|POLY 6             |     P=0.411N     P=0.135      P=0.097      P=0.524     |P=0.549N     P=0.506      P=0.510      (e)          |
|LOGISTIC REGRESSION|     P=0.427N     P=0.117      P=0.098      P=0.521     |P=0.512N     P=0.499      P=0.479      (e)          |
|COCH-ARM / FISHERS |     P=0.442N     P=0.102      P=0.102      P=0.500     |P=0.536N     P=0.500      P=0.500      (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 12

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         9.2%         2.5%         4.7%        |2.2%         2.2%         4.4%         2.3%         |
|TERMINAL (d)       |     1/24 (4%)    4/30 (13%)   0/20 (0%)    2/28 (7%)   |1/36 (3%)    1/38 (3%)    2/35 (6%)    0/35 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      676          729 (T)     |730 (T)      730 (T)      730 (T)      614          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.554N     P=0.250      P=0.744      P=0.554     |P=0.646      P=0.750N     P=0.490      P=0.755      |
|POLY 3             |     P=0.566N     P=0.206      P=0.758N     P=0.522     |P=0.644      P=0.759N     P=0.511      P=0.753      |
|POLY 1.5           |     P=0.573N     P=0.197      P=0.757N     P=0.517     |P=0.648      P=0.760N     P=0.507      P=0.755      |
|POLY 6             |     P=0.563N     P=0.217      P=0.761N     P=0.525     |P=0.643      P=0.757N     P=0.514      P=0.753      |
|LOGISTIC REGRESSION|     P=0.579N     P=0.250      P=0.763      P=0.554     |P=0.652      P=0.750N     P=0.490      P=0.757N     |
|COCH-ARM / FISHERS |     P=0.591N     P=0.181      P=0.753N     P=0.500     |P=0.640N     P=0.753N     P=0.500      P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          715          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.659N     (e)          P=0.204      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.670N     (e)          P=0.239      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.670N     (e)          P=0.240      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.673N     (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.668N     (e)          P=0.227      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 13

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   8/50 (16%)   7/50 (14%)  |8/50 (16%)   4/50 (8%)    3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     7.5%         13.7%        19.4%        16.3%       |17.4%        8.8%         6.5%         9.4%         |
|TERMINAL (d)       |     2/24 (8%)    5/30 (17%)   5/20 (25%)   6/28 (21%)  |5/36 (14%)   2/38 (5%)    2/35 (6%)    4/35 (11%)   |
|FIRST INCIDENCE    |     597          663          523          569         |429          540          687          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.293      P=0.348      P=0.072      P=0.213     |P=0.288N     P=0.173N     P=0.108N     P=0.202N     |
|POLY 3             |     P=0.268      P=0.284      P=0.103      P=0.182     |P=0.287N     P=0.181N     P=0.099N     P=0.216N     |
|POLY 1.5           |     P=0.265      P=0.270      P=0.104      P=0.177     |P=0.275N     P=0.181N     P=0.099N     P=0.203N     |
|POLY 6             |     P=0.264      P=0.299      P=0.099      P=0.184     |P=0.298N     P=0.180N     P=0.099N     P=0.228N     |
|LOGISTIC REGRESSION|     P=0.260      P=0.294      P=0.103      P=0.183     |P=0.241N     P=0.178N     P=0.117N     P=0.174N     |
|COCH-ARM / FISHERS |     P=0.243      P=0.243      P=0.100      P=0.159     |P=0.253N     P=0.178N     P=0.100N     P=0.178N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.3%         7.4%         2.4%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     633          663          708          690         |---          ---          676          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.593N     P=0.728N     P=0.282      P=0.736N    |P=0.799N     (e)          P=0.519      (e)          |
|POLY 3             |     P=0.595N     P=0.741N     P=0.306      P=0.748N    |P=0.793N     (e)          P=0.507      (e)          |
|POLY 1.5           |     P=0.595N     P=0.748N     P=0.309      P=0.751N    |P=0.791N     (e)          P=0.505      (e)          |
|POLY 6             |     P=0.600N     P=0.734N     P=0.299      P=0.747N    |P=0.794N     (e)          P=0.510      (e)          |
|LOGISTIC REGRESSION|     P=0.597N     P=0.749      P=0.307      P=0.759     |P=0.779N     (e)          P=0.488      (e)          |
|COCH-ARM / FISHERS |     P=0.605N     P=0.753N     P=0.309      P=0.753N    |P=0.786N     (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 14

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.5%         0.0%         0.0%        |2.2%         2.2%         2.2%         4.7%         |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    0/20 (0%)    0/28 (0%)   |1/36 (3%)    1/38 (3%)    0/35 (0%)    2/35 (6%)    |
|FIRST INCIDENCE    |     ---          386          ---          ---         |730 (T)      730 (T)      662          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.381N     P=0.274      (e)          (e)         |P=0.338      P=0.750N     P=0.751N     P=0.490      |
|POLY 3             |     P=0.365N     P=0.262      (e)          (e)         |P=0.344      P=0.759N     P=0.752N     P=0.485      |
|POLY 1.5           |     P=0.374N     P=0.253      (e)          (e)         |P=0.349      P=0.760N     P=0.755N     P=0.489      |
|POLY 6             |     P=0.357N     P=0.271      (e)          (e)         |P=0.340      P=0.757N     P=0.749N     P=0.483      |
|LOGISTIC REGRESSION|     P=0.485N     P=0.143      (e)          (e)         |P=0.340      P=0.750N     P=0.761      P=0.490      |
|COCH-ARM / FISHERS |     P=0.392N     P=0.247      (e)          (e)         |P=0.360      P=0.753N     P=0.753N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          676          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.656N     (e)          P=0.230      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.670N     (e)          P=0.240      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.670N     (e)          P=0.241      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.673N     (e)          P=0.237      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.670N     (e)          P=0.238      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 15

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  48/50 (96%)  41/50 (82%)  44/50 (88%) |39/50 (78%)  43/50 (86%)  42/50 (84%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     93.0%        97.6%        89.9%        92.8%       |80.4%        91.3%        86.5%        91.7%        |
|TERMINAL (d)       |     24/24 (100%) 30/30 (100%) 20/20 (100%) 28/28 (100%)|29/36 (81%)  36/38 (95%)  32/35 (91%)  34/35 (97%)  |
|FIRST INCIDENCE    |     312          386          508          537         |414          540          526          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.347N     P=0.410N     P=0.349      P=0.360N    |P=0.238      P=0.416      P=0.321      P=0.252      |
|POLY 3             |     P=0.417N     P=0.237      P=0.433N     P=0.677N    |P=0.150      P=0.097      P=0.290      P=0.084      |
|POLY 1.5           |     P=0.436N     P=0.130      P=0.429N     P=0.599     |P=0.231      P=0.130      P=0.299      P=0.145      |
|POLY 6             |     P=0.489N     P=0.367      P=0.511N     P=0.737N    |P=0.095      P=0.078      P=0.272      P=0.050      |
|LOGISTIC REGRESSION|     P=0.286N     P=0.136      P=0.383N     P=0.524N    |P=0.228      P=0.214      P=0.343      P=0.193      |
|COCH-ARM / FISHERS |     P=0.544N     P=0.046 *    P=0.500N     P=0.387     |P=0.408      P=0.218      P=0.306      P=0.306      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  4/50 (8%)    15/50 (30%)  19/50 (38%) |5/50 (10%)   2/50 (4%)    9/50 (18%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     29.8%        9.0%         34.1%        41.2%       |11.1%        4.4%         19.2%        20.4%        |
|TERMINAL (d)       |     4/24 (17%)   0/30 (0%)    2/20 (10%)   7/28 (25%)  |2/36 (6%)    1/38 (3%)    5/35 (14%)   4/35 (11%)   |
|FIRST INCIDENCE    |     361          585          537          569         |645          659          575          631          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.025 *    P=0.012N*    P=0.375      P=0.263     |P=0.047 *    P=0.209N     P=0.220      P=0.182      |
|POLY 3             |     P=0.010 *    P=0.012N*    P=0.421      P=0.179     |P=0.046 *    P=0.216N     P=0.215      P=0.178      |
|POLY 1.5           |     P=0.009 **   P=0.013N*    P=0.419      P=0.166     |P=0.048 *    P=0.216N     P=0.207      P=0.181      |
|POLY 6             |     P=0.012 *    P=0.011N*    P=0.431      P=0.201     |P=0.047 *    P=0.216N     P=0.223      P=0.180      |
|LOGISTIC REGRESSION|     P=0.006 **   P=0.027N*    P=0.384      P=0.103     |P=0.056      P=0.217N     P=0.186      P=0.191      |
|COCH-ARM / FISHERS |     P=0.009 **   P=0.016N*    P=0.412      P=0.142     |P=0.055      P=0.218N     P=0.194      P=0.194      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 16

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Pelvis                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         0.0%        |4.5%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |2/36 (6%)    1/38 (3%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          602          ---         |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.780N     (e)          P=0.490      (e)         |P=0.177N     P=0.481N     P=0.244N     P=0.244N     |
|POLY 3             |     P=0.776N     (e)          P=0.504      (e)         |P=0.173N     P=0.497N     P=0.230N     P=0.247N     |
|POLY 1.5           |     P=0.776N     (e)          P=0.504      (e)         |P=0.172N     P=0.498N     P=0.233N     P=0.244N     |
|POLY 6             |     P=0.777N     (e)          P=0.503      (e)         |P=0.174N     P=0.494N     P=0.228N     P=0.248N     |
|LOGISTIC REGRESSION|     P=0.820N     (e)          P=0.478      (e)         |P=0.177N     P=0.481N     (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.779N     (e)          P=0.500      (e)         |P=0.169N     P=0.500N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         0.0%        |0.0%         2.2%         2.2%         4.7%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    1/38 (3%)    1/35 (3%)    2/35 (6%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          730 (T)      730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.761N     (e)          P=0.464      (e)         |P=0.181      P=0.511      P=0.494      P=0.232      |
|POLY 3             |     P=0.776N     (e)          P=0.502      (e)         |P=0.183      P=0.502      P=0.506      P=0.228      |
|POLY 1.5           |     P=0.776N     (e)          P=0.503      (e)         |P=0.186      P=0.501      P=0.504      P=0.230      |
|POLY 6             |     P=0.777N     (e)          P=0.499      (e)         |P=0.180      P=0.503      P=0.508      P=0.226      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.464      (e)         |(e)          P=0.511      P=0.494      P=0.232      |
|COCH-ARM / FISHERS |     P=0.779N     (e)          P=0.500      (e)         |P=0.194      P=0.500      P=0.500      P=0.247      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 17

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  29/50 (58%)  26/50 (52%)  27/50 (54%) |47/50 (94%)  48/50 (96%)  43/50 (86%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     70.7%        64.9%        59.4%        59.9%       |96.7%        98.0%        89.1%        79.3%        |
|TERMINAL (d)       |     22/24 (92%)  24/30 (80%)  16/20 (80%)  21/28 (75%) |36/36 (100%) 38/38 (100%) 34/35 (97%)  30/35 (86%)  |
|FIRST INCIDENCE    |     312          410          482          490         |414          403          468          414          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188N     P=0.087N     P=0.536N     P=0.107N    |P=0.014N*    P=0.479N     P=0.298N     P=0.032N*    |
|POLY 3             |     P=0.221N     P=0.353N     P=0.175N     P=0.186N    |P<0.001N**   P=0.614      P=0.111N     P=0.004N**   |
|POLY 1.5           |     P=0.256N     P=0.400N     P=0.203N     P=0.232N    |P<0.001N**   P=0.550      P=0.125N     P=0.004N**   |
|POLY 6             |     P=0.197N     P=0.317N     P=0.156N     P=0.155N    |P<0.001N**   P=0.728      P=0.117N     P=0.006N**   |
|LOGISTIC REGRESSION|     P=0.264N     P=0.257N     P=0.238N     P=0.210N    |P<0.001N**   P=0.490      P=0.088N     P=0.006N**   |
|COCH-ARM / FISHERS |     P=0.337N     P=0.500N     P=0.273N     P=0.343N    |P<0.001N**   P=0.500      P=0.159N     P=0.003N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   11/50 (22%)  2/50 (4%)    4/50 (8%)   |2/50 (4%)    5/50 (10%)   1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     15.1%        25.3%        5.0%         9.4%        |4.5%         11.1%        2.2%         4.7%         |
|TERMINAL (d)       |     6/24 (25%)   11/30 (37%)  2/20 (10%)   4/28 (14%)  |2/36 (6%)    5/38 (13%)   1/35 (3%)    2/35 (6%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |730 (T)      730 (T)      730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.091N     P=0.269      P=0.189N     P=0.268N    |P=0.388N     P=0.237      P=0.510N     P=0.685      |
|POLY 3             |     P=0.103N     P=0.187      P=0.127N     P=0.329N    |P=0.382N     P=0.220      P=0.489N     P=0.679      |
|POLY 1.5           |     P=0.109N     P=0.171      P=0.127N     P=0.339N    |P=0.377N     P=0.218      P=0.493N     P=0.683      |
|POLY 6             |     P=0.099N     P=0.205      P=0.130N     P=0.322N    |P=0.385N     P=0.222      P=0.486N     P=0.676      |
|LOGISTIC REGRESSION|     P=0.091N     P=0.269      P=0.189N     P=0.268N    |P=0.388N     P=0.237      P=0.510N     P=0.685      |
|COCH-ARM / FISHERS |     P=0.128N     P=0.143      P=0.134N     P=0.370N    |P=0.364N     P=0.218      P=0.500N     P=0.691N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 18

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    4/50 (8%)    6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.9%         9.0%         9.9%         13.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/24 (8%)    1/30 (3%)    2/20 (10%)   2/28 (7%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     648          410          646          529         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.314      P=0.540N     P=0.608      P=0.444     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.294      P=0.586N     P=0.640N     P=0.419     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.291      P=0.605N     P=0.636N     P=0.405     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.294      P=0.566N     P=0.642      P=0.430     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.272      P=0.626      P=0.642N     P=0.385     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.274      P=0.643N     P=0.643N     P=0.370     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   8/50 (16%)   6/50 (12%)   8/50 (16%)  |9/50 (18%)   10/50 (20%)  14/50 (28%)  7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     15.1%        18.3%        14.9%        18.8%       |20.2%        22.1%        30.4%        16.3%        |
|TERMINAL (d)       |     6/24 (25%)   7/30 (23%)   5/20 (25%)   7/28 (25%)  |8/36 (22%)   9/38 (24%)   13/35 (37%)  6/35 (17%)   |
|FIRST INCIDENCE    |     729 (T)      663          691          659         |723          633          701          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.475      P=0.565      P=0.507      P=0.507     |P=0.319N     P=0.550      P=0.151      P=0.419N     |
|POLY 3             |     P=0.439      P=0.461      P=0.614N     P=0.440     |P=0.315N     P=0.516      P=0.190      P=0.421N     |
|POLY 1.5           |     P=0.433      P=0.434      P=0.610N     P=0.425     |P=0.303N     P=0.508      P=0.183      P=0.414N     |
|POLY 6             |     P=0.438      P=0.492      P=0.623N     P=0.451     |P=0.322N     P=0.529      P=0.196      P=0.422N     |
|LOGISTIC REGRESSION|     P=0.430      P=0.524      P=0.574      P=0.459     |P=0.328N     P=0.522      P=0.184      P=0.435N     |
|COCH-ARM / FISHERS |     P=0.407      P=0.387      P=0.620N     P=0.387     |P=0.273N     P=0.500      P=0.171      P=0.393N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 19

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   10/50 (20%)  4/50 (8%)   |9/50 (18%)   11/50 (22%)  12/50 (24%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     17.2%        11.5%        24.5%        9.3%        |19.9%        23.5%        25.8%        29.8%        |
|TERMINAL (d)       |     4/24 (17%)   4/30 (13%)   5/20 (25%)   2/28 (7%)   |7/36 (19%)   6/38 (16%)   9/35 (26%)   6/35 (17%)   |
|FIRST INCIDENCE    |     633          709          602          529         |575          451          575          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.226N     P=0.257N     P=0.221      P=0.207N    |P=0.141      P=0.449      P=0.306      P=0.169      |
|POLY 3             |     P=0.225N     P=0.329N     P=0.295      P=0.225N    |P=0.178      P=0.431      P=0.335      P=0.193      |
|POLY 1.5           |     P=0.229N     P=0.345N     P=0.304      P=0.234N    |P=0.173      P=0.418      P=0.327      P=0.184      |
|POLY 6             |     P=0.228N     P=0.317N     P=0.276      P=0.223N    |P=0.184      P=0.449      P=0.340      P=0.204      |
|LOGISTIC REGRESSION|     P=0.232N     P=0.304N     P=0.292      P=0.238N    |P=0.209      P=0.399      P=0.328      P=0.221      |
|COCH-ARM / FISHERS |     P=0.250N     P=0.380N     P=0.298      P=0.262N    |P=0.162      P=0.402      P=0.312      P=0.171      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  27/50 (54%)  19/50 (38%)  21/50 (42%) |43/50 (86%)  44/50 (88%)  39/50 (78%)  30/50 (60%)  |
|POLY-3 ADJUSTED (b)|     43.3%        58.7%        44.2%        47.5%       |92.3%        89.2%        81.1%        68.8%        |
|TERMINAL (d)       |     14/24 (58%)  20/30 (67%)  13/20 (65%)  17/28 (61%) |35/36 (97%)  35/38 (92%)  33/35 (94%)  27/35 (77%)  |
|FIRST INCIDENCE    |     312          386          482          490         |575          403          468          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.364N     P=0.230      P=0.297      P=0.551     |P=0.002N**   P=0.492N     P=0.280N     P=0.007N**   |
|POLY 3             |     P=0.440N     P=0.103      P=0.558      P=0.432     |P<0.001N**   P=0.423N     P=0.075N     P=0.002N**   |
|POLY 1.5           |     P=0.452N     P=0.081      P=0.543      P=0.405     |P<0.001N**   P=0.546N     P=0.114N     P=0.002N**   |
|POLY 6             |     P=0.444N     P=0.134      P=0.566      P=0.451     |P<0.001N**   P=0.316N     P=0.057N     P=0.002N**   |
|LOGISTIC REGRESSION|     P=0.451N     P=0.090      P=0.518      P=0.428     |P<0.001N**   P=0.508      P=0.105N     P=0.002N**   |
|COCH-ARM / FISHERS |     P=0.500N     P=0.054      P=0.500      P=0.341     |P<0.001N**   P=0.500      P=0.218N     P=0.003N**   |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 20

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   17/50 (34%)  8/50 (16%)   11/50 (22%) |8/50 (16%)   19/50 (38%)  7/50 (14%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     17.6%        38.9%        19.9%        26.0%       |17.8%        42.3%        15.2%        21.1%        |
|TERMINAL (d)       |     7/24 (29%)   16/30 (53%)  7/20 (35%)   11/28 (39%) |7/36 (19%)   19/38 (50%)  6/35 (17%)   9/35 (26%)   |
|FIRST INCIDENCE    |     729 (T)      663          708          729 (T)     |613          730 (T)      708          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.477N     P=0.046 *    P=0.349      P=0.320     |P=0.245N     P=0.014 *    P=0.516N     P=0.473      |
|POLY 3             |     P=0.518N     P=0.025 *    P=0.510      P=0.256     |P=0.242N     P=0.009 **   P=0.480N     P=0.453      |
|POLY 1.5           |     P=0.529N     P=0.021 *    P=0.513      P=0.248     |P=0.230N     P=0.009 **   P=0.486N     P=0.468      |
|POLY 6             |     P=0.518N     P=0.030 *    P=0.498      P=0.259     |P=0.253N     P=0.008 **   P=0.475N     P=0.440      |
|LOGISTIC REGRESSION|     P=0.527N     P=0.039 *    P=0.392      P=0.320     |P=0.254N     P=0.012 *    P=0.466N     P=0.453      |
|COCH-ARM / FISHERS |     P=0.553      P=0.017 *    P=0.500      P=0.218     |P=0.208N     P=0.012 *    P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    4/50 (8%)   |3/50 (6%)    0/50 (0%)    1/50 (2%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     9.8%         2.3%         7.4%         9.4%        |6.7%         0.0%         2.2%         9.1%         |
|TERMINAL (d)       |     1/24 (4%)    1/30 (3%)    0/20 (0%)    1/28 (4%)   |1/36 (3%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     368          729 (T)      676          701         |645          ---          703          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.397      P=0.140N     P=0.533N     P=0.582N    |P=0.131      P=0.121N     P=0.296N     P=0.470      |
|POLY 3             |     P=0.365      P=0.160N     P=0.507N     P=0.624N    |P=0.140      P=0.119N     P=0.297N     P=0.489      |
|POLY 1.5           |     P=0.369      P=0.167N     P=0.500N     P=0.627N    |P=0.141      P=0.119N     P=0.300N     P=0.490      |
|POLY 6             |     P=0.357      P=0.154N     P=0.518N     P=0.624N    |P=0.141      P=0.119N     P=0.295N     P=0.490      |
|LOGISTIC REGRESSION|     P=0.372      P=0.208N     P=0.506N     P=0.640     |P=0.178      P=0.121N     P=0.310N     P=0.538      |
|COCH-ARM / FISHERS |     P=0.366      P=0.181N     P=0.500N     P=0.643N    |P=0.147      P=0.121N     P=0.309N     P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 21

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     512          ---          ---          ---         |---          ---          625          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.255N     P=0.209N     P=0.257N     P=0.214N    |P=0.796N     (e)          P=0.509      (e)          |
|POLY 3             |     P=0.271N     P=0.221N     P=0.238N     P=0.226N    |P=0.793N     (e)          P=0.508      (e)          |
|POLY 1.5           |     P=0.268N     P=0.226N     P=0.236N     P=0.229N    |P=0.791N     (e)          P=0.505      (e)          |
|POLY 6             |     P=0.274N     P=0.215N     P=0.243N     P=0.226N    |P=0.794N     (e)          P=0.511      (e)          |
|LOGISTIC REGRESSION|     P=0.282N     P=0.269N     P=0.249N     P=0.270N    |P=0.750N     (e)          P=0.454      (e)          |
|COCH-ARM / FISHERS |     P=0.262N     P=0.247N     P=0.247N     P=0.247N    |P=0.786N     (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         4.9%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          410          602          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.491N     P=0.513      P=0.216      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.485N     P=0.521      P=0.241      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.487N     P=0.514      P=0.241      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.485N     P=0.529      P=0.239      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.597N     P=0.260      P=0.237      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 22

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   4/50 (8%)    2/50 (4%)    5/50 (10%)  |7/50 (14%)   11/50 (22%)  9/50 (18%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     22.2%        9.2%         5.0%         11.8%       |15.5%        24.1%        19.3%        20.3%        |
|TERMINAL (d)       |     7/24 (29%)   2/30 (7%)    1/20 (5%)    5/28 (18%)  |5/36 (14%)   8/38 (21%)   4/35 (11%)   5/35 (14%)   |
|FIRST INCIDENCE    |     617          687          725          729 (T)     |613          652          575          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.308N     P=0.060N     P=0.048N*    P=0.121N    |P=0.467      P=0.262      P=0.400      P=0.370      |
|POLY 3             |     P=0.346N     P=0.085N     P=0.024N*    P=0.164N    |P=0.502      P=0.222      P=0.421      P=0.378      |
|POLY 1.5           |     P=0.343N     P=0.095N     P=0.023N*    P=0.170N    |P=0.506      P=0.219      P=0.411      P=0.380      |
|POLY 6             |     P=0.356N     P=0.076N     P=0.026N*    P=0.164N    |P=0.505      P=0.228      P=0.430      P=0.382      |
|LOGISTIC REGRESSION|     P=0.330N     P=0.077N     P=0.027N*    P=0.149N    |P=0.512      P=0.221      P=0.401      P=0.394      |
|COCH-ARM / FISHERS |     P=0.347N     P=0.117N     P=0.026N*    P=0.194N    |P=0.525      P=0.218      P=0.393      P=0.393      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     46/50 (92%)  47/50 (94%)  44/50 (88%)  48/50 (96%) |5/50 (10%)   12/50 (24%)  21/50 (42%)  32/50 (64%)  |
|POLY-3 ADJUSTED (b)|     97.0%        94.8%        94.3%        96.5%       |10.9%        26.1%        44.8%        71.3%        |
|TERMINAL (d)       |     24/24 (100%) 28/30 (93%)  19/20 (95%)  27/28 (96%) |2/36 (6%)    8/38 (21%)   16/35 (46%)  25/35 (71%)  |
|FIRST INCIDENCE    |     313          386          508          490         |501          616          625          465          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.498N     P=0.165N     P=0.425      P=0.368N    |P<0.001 **   P=0.076      P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.561      P=0.491N     P=0.442N     P=0.684N    |P<0.001 **   P=0.052      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.462      P=0.589N     P=0.362N     P=0.647     |P<0.001 **   P=0.052      P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.617      P=0.461N     P=0.609N     P=0.653N    |P<0.001 **   P=0.054      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.486      P=0.624N     P=0.170N     P=0.618     |P<0.001 **   P=0.054      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.291      P=0.500      P=0.370N     P=0.339     |P<0.001 **   P=0.054      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 23

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/50 (36%)  15/50 (30%)  20/50 (40%)  23/50 (46%) |1/50 (2%)    5/50 (10%)   10/50 (20%)  7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     41.1%        32.2%        44.1%        48.1%       |2.2%         11.0%        21.1%        15.3%        |
|TERMINAL (d)       |     4/24 (17%)   3/30 (10%)   1/20 (5%)    6/28 (21%)  |0/36 (0%)    2/38 (5%)    3/35 (9%)    1/35 (3%)    |
|FIRST INCIDENCE    |     512          585          444          529         |701          659          575          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.171      P=0.215N     P=0.380      P=0.363     |P=0.089      P=0.119      P=0.009 **   P=0.034 *    |
|POLY 3             |     P=0.138      P=0.254N     P=0.468      P=0.321     |P=0.104      P=0.106      P=0.006 **   P=0.032 *    |
|POLY 1.5           |     P=0.123      P=0.277N     P=0.461      P=0.286     |P=0.099      P=0.104      P=0.005 **   P=0.031 *    |
|POLY 6             |     P=0.150      P=0.238N     P=0.464      P=0.350     |P=0.112      P=0.110      P=0.007 **   P=0.035 *    |
|LOGISTIC REGRESSION|     P=0.074      P=0.360N     P=0.411      P=0.173     |P=0.145      P=0.103      P=0.004 **   P=0.051      |
|COCH-ARM / FISHERS |     P=0.093      P=0.335N     P=0.418      P=0.208     |P=0.099      P=0.102      P=0.004 **   P=0.030 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    16/50 (32%) |0/50 (0%)    2/50 (4%)    24/50 (48%)  38/50 (76%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         7.5%         37.3%       |0.0%         4.4%         52.2%        83.6%        |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    3/20 (15%)   15/28 (54%) |0/36 (0%)    1/38 (3%)    22/35 (63%)  33/35 (94%)  |
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      569         |---          666          708          347          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.545      P=0.089      P<0.001 **  |P<0.001 **   P=0.254      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.518      P=0.119      P<0.001 **  |P<0.001 **   P=0.240      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.512      P=0.121      P<0.001 **  |P<0.001 **   P=0.239      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.524      P=0.116      P<0.001 **  |P<0.001 **   P=0.243      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.545      P=0.089      P<0.001 **  |P<0.001 **   P=0.238      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.121      P<0.001 **  |P<0.001 **   P=0.247      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 24

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         7.3%         9.2%        |0.0%         2.2%         2.2%         2.3%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    1/35 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     640          ---          549          569         |---          690          730 (T)      637          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.121      P=0.205N     P=0.482      P=0.378     |P=0.467      P=0.500      P=0.494      P=0.486      |
|POLY 3             |     P=0.116      P=0.219N     P=0.512      P=0.373     |P=0.471      P=0.503      P=0.506      P=0.493      |
|POLY 1.5           |     P=0.115      P=0.225N     P=0.511      P=0.363     |P=0.475      P=0.501      P=0.504      P=0.495      |
|POLY 6             |     P=0.116      P=0.214N     P=0.511      P=0.382     |P=0.469      P=0.505      P=0.508      P=0.493      |
|LOGISTIC REGRESSION|     P=0.097      P=0.228N     P=0.493      P=0.330     |P=0.491      P=0.500      P=0.494      P=0.523      |
|COCH-ARM / FISHERS |     P=0.111      P=0.247N     P=0.500      P=0.339     |P=0.485      P=0.500      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  16/50 (32%)  14/50 (28%)  18/50 (36%) |23/50 (46%)  21/50 (42%)  23/50 (46%)  31/50 (62%)  |
|POLY-3 ADJUSTED (b)|     26.3%        36.0%        33.0%        40.8%       |49.5%        45.7%        48.4%        68.4%        |
|TERMINAL (d)       |     6/24 (25%)   12/30 (40%)  8/20 (40%)   13/28 (46%) |17/36 (47%)  19/38 (50%)  18/35 (51%)  23/35 (66%)  |
|FIRST INCIDENCE    |     368          603          523          537         |575          403          468          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199      P=0.372      P=0.236      P=0.183     |P=0.018 *    P=0.348N     P=0.555      P=0.079      |
|POLY 3             |     P=0.150      P=0.229      P=0.332      P=0.113     |P=0.015 *    P=0.439N     P=0.538N     P=0.047 *    |
|POLY 1.5           |     P=0.149      P=0.213      P=0.334      P=0.109     |P=0.017 *    P=0.426N     P=0.547N     P=0.054      |
|POLY 6             |     P=0.143      P=0.249      P=0.324      P=0.111     |P=0.015 *    P=0.466N     P=0.547N     P=0.045 *    |
|LOGISTIC REGRESSION|     P=0.151      P=0.234      P=0.330      P=0.114     |P=0.015 *    P=0.409N     P=0.555N     P=0.052      |
|COCH-ARM / FISHERS |     P=0.133      P=0.184      P=0.322      P=0.093     |P=0.027 *    P=0.420N     P=0.579N     P=0.080      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 25

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.7%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    1/35 (3%)    |
|FIRST INCIDENCE    |     723          617          ---          ---         |---          ---          ---          707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.324N     P=0.730N     P=0.533N     P=0.478N    |P=0.039 *    (e)          (e)          P=0.234      |
|POLY 3             |     P=0.321N     P=0.739N     P=0.498N     P=0.488N    |P=0.038 *    (e)          (e)          P=0.228      |
|POLY 1.5           |     P=0.322N     P=0.747N     P=0.497N     P=0.491N    |P=0.039 *    (e)          (e)          P=0.231      |
|POLY 6             |     P=0.321N     P=0.730N     P=0.502N     P=0.486N    |P=0.038 *    (e)          (e)          P=0.227      |
|LOGISTIC REGRESSION|     P=0.326N     P=0.763      P=0.509N     P=0.482N    |P=0.036 *    (e)          (e)          P=0.227      |
|COCH-ARM / FISHERS |     P=0.325N     P=0.753N     P=0.500N     P=0.500N    |P=0.042 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |40/50 (80%)  40/50 (80%)  42/50 (84%)  35/50 (70%)  |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         0.0%        |85.1%        84.6%        88.0%        81.5%        |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |31/36 (86%)  34/38 (90%)  33/35 (94%)  34/35 (97%)  |
|FIRST INCIDENCE    |     633          ---          ---          ---         |575          429          526          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.502N     P=0.480N     P=0.505N     P=0.495N    |P=0.242N     P=0.423N     P=0.383      P=0.244N     |
|POLY 3             |     P=0.510N     P=0.484N     P=0.500N     P=0.489N    |P=0.357N     P=0.594N     P=0.455      P=0.422N     |
|POLY 1.5           |     P=0.507N     P=0.489N     P=0.498N     P=0.491N    |P=0.222N     P=0.590N     P=0.446      P=0.297N     |
|POLY 6             |     P=0.513N     P=0.479N     P=0.504N     P=0.489N    |P=0.575N     P=0.623N     P=0.418      P=0.624N     |
|LOGISTIC REGRESSION|     P=0.518N     P=0.526N     P=0.508N     P=0.527N    |P=0.200N     P=0.586N     P=0.536      P=0.269N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.500N     P=0.500N    |P=0.098N     P=0.598N     P=0.398      P=0.178N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 26

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.3%         5.0%         0.0%        |0.0%         2.2%         2.2%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     633          723          712          ---         |---          690          662          701          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.319N     P=0.729N     P=0.470      P=0.495N    |P=0.467      P=0.500      P=0.523      P=0.495      |
|POLY 3             |     P=0.319N     P=0.743N     P=0.501      P=0.489N    |P=0.469      P=0.503      P=0.507      P=0.492      |
|POLY 1.5           |     P=0.319N     P=0.748N     P=0.504      P=0.491N    |P=0.474      P=0.501      P=0.505      P=0.494      |
|POLY 6             |     P=0.322N     P=0.737N     P=0.494      P=0.489N    |P=0.466      P=0.505      P=0.510      P=0.491      |
|LOGISTIC REGRESSION|     P=0.319N     P=0.761N     P=0.503      P=0.527N    |P=0.492      P=0.500      P=0.479      P=0.495      |
|COCH-ARM / FISHERS |     P=0.325N     P=0.753N     P=0.500      P=0.500N    |P=0.485      P=0.500      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   7/50 (14%)   2/50 (4%)    5/50 (10%)  |8/50 (16%)   7/50 (14%)   9/50 (18%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     22.3%        16.1%        5.0%         11.8%       |17.9%        15.6%        19.6%        20.9%        |
|TERMINAL (d)       |     7/24 (29%)   7/30 (23%)   2/20 (10%)   3/28 (11%)  |7/36 (19%)   7/38 (18%)   8/35 (23%)   8/35 (23%)   |
|FIRST INCIDENCE    |     613          729 (T)      729 (T)      699         |645          730 (T)      708          614          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.176N     P=0.222N     P=0.044N*    P=0.128N    |P=0.342      P=0.456N     P=0.483      P=0.470      |
|POLY 3             |     P=0.199N     P=0.328N     P=0.023N*    P=0.160N    |P=0.353      P=0.498N     P=0.524      P=0.464      |
|POLY 1.5           |     P=0.201N     P=0.349N     P=0.023N*    P=0.168N    |P=0.365      P=0.499N     P=0.516      P=0.474      |
|POLY 6             |     P=0.199N     P=0.309N     P=0.025N*    P=0.157N    |P=0.345      P=0.496N     P=0.529      P=0.458      |
|LOGISTIC REGRESSION|     P=0.195N     P=0.268N     P=0.027N*    P=0.148N    |P=0.332      P=0.482N     P=0.540      P=0.456      |
|COCH-ARM / FISHERS |     P=0.213N     P=0.393N     P=0.026N*    P=0.194N    |P=0.396      P=0.500N     P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 27

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   3/49 (6%)    2/50 (4%)   |1/49 (2%)    8/50 (16%)   5/48 (10%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     7.5%         11.5%        7.6%         4.7%        |2.3%         17.7%        11.2%        11.7%        |
|TERMINAL (d)       |     3/24 (13%)   5/30 (17%)   2/20 (10%)   1/28 (4%)   |1/35 (3%)    7/38 (18%)   5/35 (14%)   5/35 (14%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      691          701         |730 (T)      680          730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.247N     P=0.483      P=0.600      P=0.435N    |P=0.393      P=0.024 *    P=0.102      P=0.102      |
|POLY 3             |     P=0.256N     P=0.406      P=0.661      P=0.470N    |P=0.394      P=0.018 *    P=0.107      P=0.096      |
|POLY 1.5           |     P=0.261N     P=0.389      P=0.661      P=0.478N    |P=0.404      P=0.018 *    P=0.103      P=0.099      |
|POLY 6             |     P=0.254N     P=0.424      P=0.658      P=0.465N    |P=0.387      P=0.019 *    P=0.111      P=0.094      |
|LOGISTIC REGRESSION|     P=0.262N     P=0.483      P=0.645      P=0.457N    |P=0.384      P=0.021 *    P=0.102      P=0.102      |
|COCH-ARM / FISHERS |     P=0.278N     P=0.357      P=0.651      P=0.500N    |P=0.430      P=0.017 *    P=0.097      P=0.107      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    4/50 (8%)    1/48 (2%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     10.1%        2.3%         0.0%         0.0%        |0.0%         8.8%         2.2%         11.5%        |
|TERMINAL (d)       |     3/24 (13%)   0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/35 (0%)    2/38 (5%)    0/35 (0%)    2/35 (6%)    |
|FIRST INCIDENCE    |     723          603          ---          ---         |---          652          723          614          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.066N     P=0.133N     P=0.088N     P=0.047N*   |P=0.057      P=0.074      P=0.500      P=0.034 *    |
|POLY 3             |     P=0.067N     P=0.150N     P=0.060N     P=0.052N    |P=0.062      P=0.066      P=0.505      P=0.030 *    |
|POLY 1.5           |     P=0.066N     P=0.160N     P=0.060N     P=0.054N    |P=0.063      P=0.064      P=0.502      P=0.030 *    |
|POLY 6             |     P=0.070N     P=0.138N     P=0.061N     P=0.050N    |P=0.062      P=0.068      P=0.509      P=0.030 *    |
|LOGISTIC REGRESSION|     P=0.064N     P=0.152N     P=0.074N     P=0.048N*   |P=0.067      P=0.066      P=0.510      P=0.034 *    |
|COCH-ARM / FISHERS |     P=0.066N     P=0.181N     P=0.061N     P=0.059N    |P=0.068      P=0.061      P=0.495      P=0.030 *    |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 28

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    4/50 (8%)    3/50 (6%)   |26/50 (52%)  19/50 (38%)  26/50 (52%)  24/50 (48%)  |
|POLY-3 ADJUSTED (b)|     9.9%         2.3%         9.6%         6.9%        |54.7%        41.8%        56.0%        55.5%        |
|TERMINAL (d)       |     2/24 (8%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |18/36 (50%)  17/38 (45%)  22/35 (63%)  22/35 (63%)  |
|FIRST INCIDENCE    |     613          585          537          529         |414          652          667          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.591      P=0.141N     P=0.603      P=0.453N    |P=0.359      P=0.094N     P=0.554      P=0.492N     |
|POLY 3             |     P=0.589      P=0.154N     P=0.628N     P=0.459N    |P=0.306      P=0.148N     P=0.531      P=0.554      |
|POLY 1.5           |     P=0.588      P=0.162N     P=0.629N     P=0.470N    |P=0.363      P=0.133N     P=0.555      P=0.544N     |
|POLY 6             |     P=0.586      P=0.146N     P=0.632N     P=0.452N    |P=0.252      P=0.169N     P=0.490      P=0.479      |
|LOGISTIC REGRESSION|     P=0.511      P=0.188N     P=0.634      P=0.546N    |P=0.360      P=0.109N     P=0.537N     P=0.494N     |
|COCH-ARM / FISHERS |     P=0.576      P=0.181N     P=0.643N     P=0.500N    |P=0.472      P=0.114N     P=0.579N     P=0.421N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Reticulum Cell                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          386          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.392N     P=0.254      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.367N     P=0.264      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.376N     P=0.255      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.357N     P=0.275      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.601N     P=0.089      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.397N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 29

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Dilatation                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |2/36 (6%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.250N     P=0.226N     P=0.244N     P=0.244N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.244N     P=0.235N     P=0.230N     P=0.247N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.243N     P=0.236N     P=0.233N     P=0.244N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.245N     P=0.233N     P=0.228N     P=0.248N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.250N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.242N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    0/48 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    6/50 (12%)   1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.7%        |2.2%         0.0%         12.9%        2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    2/28 (7%)   |1/36 (3%)    0/38 (0%)    3/35 (9%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |730 (T)      ---          575          639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.052      (e)          (e)          P=0.272     |P=0.545      P=0.489N     P=0.063      P=0.746      |
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.258     |P=0.545      P=0.498N     P=0.063      P=0.753      |
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.257     |P=0.553      P=0.499N     P=0.061      P=0.755      |
|POLY 6             |     P=0.043 *    (e)          (e)          P=0.258     |P=0.541      P=0.497N     P=0.066      P=0.753      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.272     |P=0.573      (e)          P=0.059      P=0.763N     |
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.263     |P=0.573      P=0.500N     P=0.056      P=0.753N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 30

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/47 (4%)    8/50 (16%)   9/48 (19%)   6/50 (12%)  |14/50 (28%)  19/50 (38%)  20/50 (40%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     5.1%         18.0%        22.2%        14.0%       |30.3%        40.4%        42.7%        23.3%        |
|TERMINAL (d)       |     1/24 (4%)    2/30 (7%)    3/20 (15%)   3/28 (11%)  |10/36 (28%)  14/38 (37%)  17/35 (49%)  9/35 (26%)   |
|FIRST INCIDENCE    |     617          617          562          676         |501          451          575          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.453      P=0.098      P=0.025 *    P=0.182     |P=0.114N     P=0.255      P=0.144      P=0.279N     |
|POLY 3             |     P=0.458      P=0.070      P=0.027 *    P=0.163     |P=0.126N     P=0.212      P=0.151      P=0.305N     |
|POLY 1.5           |     P=0.460      P=0.064      P=0.028 *    P=0.162     |P=0.106N     P=0.205      P=0.149      P=0.283N     |
|POLY 6             |     P=0.450      P=0.078      P=0.027 *    P=0.164     |P=0.148N     P=0.221      P=0.151      P=0.325N     |
|LOGISTIC REGRESSION|     P=0.452      P=0.062      P=0.029 *    P=0.164     |P=0.089N     P=0.196      P=0.157      P=0.267N     |
|COCH-ARM / FISHERS |     P=0.445      P=0.056      P=0.027 *    P=0.155     |P=0.076N     P=0.198      P=0.146      P=0.241N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/7 (0%)     1/12 (8%)    1/12 (8%)    0/14 (0%)   |0/7 (0%)     2/8 (25%)    0/4 (0%)     0/4 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         9.7%         12.2%        0.0%        |0.0%         26.3%        0.0%         0.0%         |
|TERMINAL (d)       |     0/2 (0%)     1/7 (14%)    1/5 (20%)    0/6 (0%)    |0/5 (0%)     0/5 (0%)     0/4 (0%)     0/4 (0%)     |
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          451          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.449N     P=0.748      P=0.682      (e)         |P=0.380N     P=0.242      (e)          (e)          |
|POLY 3             |     P=0.402N     P=0.643      P=0.604      (e)         |P=0.478N     P=0.265      (e)          (e)          |
|POLY 1.5           |     P=0.414N     P=0.630      P=0.606      (e)         |P=0.488N     P=0.260      (e)          (e)          |
|POLY 6             |     P=0.391N     P=0.659      P=0.610      (e)         |P=0.466N     P=0.271      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.748      P=0.682      (e)         |P=0.916N     P=0.413      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.439N     P=0.632      P=0.632      (e)         |P=0.500N     P=0.267      (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 31

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/7 (14%)    1/12 (8%)    0/12 (0%)    2/14 (14%)  |0/7 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     |
|POLY-3 ADJUSTED (b)|     20.5%        9.7%         0.0%         16.5%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/2 (50%)    1/7 (14%)    0/5 (0%)     0/6 (0%)    |0/5 (0%)     0/5 (0%)     0/4 (0%)     0/4 (0%)     |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          633         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.390      P=0.460N     P=0.318N     P=0.643     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.493      P=0.586N     P=0.393N     P=0.679N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.480      P=0.604N     P=0.391N     P=0.700N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.506      P=0.562N     P=0.386N     P=0.649N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.488      P=0.460N     (e)          P=0.722N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.459      P=0.614N     P=0.368N     P=0.726N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/7 (43%)    7/12 (58%)   8/12 (67%)   7/14 (50%)  |6/7 (86%)    6/8 (75%)    4/4 (100%)   3/4 (75%)    |
|POLY-3 ADJUSTED (b)|     50.7%        66.2%        73.3%        57.2%       |87.5%        86.4%        100.0%       75.0%        |
|TERMINAL (d)       |     0/2 (0%)     5/7 (71%)    3/5 (60%)    5/6 (83%)   |5/5 (100%)   5/5 (100%)   4/4 (100%)   3/4 (75%)    |
|FIRST INCIDENCE    |     611          663          400          537         |575          616          730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.463      P=0.525      P=0.192      P=0.451     |P=0.079N     P=0.750N     P=0.496N     P=0.222N     |
|POLY 3             |     P=0.497N     P=0.463      P=0.347      P=0.595     |P=0.510N     P=0.785N     P=0.666      P=0.615N     |
|POLY 1.5           |     P=0.478N     P=0.473      P=0.347      P=0.603     |P=0.557N     P=0.688N     P=0.637      P=0.623N     |
|POLY 6             |     P=0.565N     P=0.423      P=0.331      P=0.546     |P=0.440N     P=0.814      P=0.727      P=0.597N     |
|LOGISTIC REGRESSION|     P=0.461N     P=0.599      P=0.298      P=0.661     |P=0.399N     P=0.742N     P=0.681      P=0.648N     |
|COCH-ARM / FISHERS |     P=0.502N     P=0.430      P=0.297      P=0.562     |P=0.622N     P=0.554N     P=0.636      P=0.618N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 32

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   3/50 (6%)    5/50 (10%)  |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     12.4%        13.8%        7.4%         11.6%       |4.5%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     4/24 (17%)   4/30 (13%)   0/20 (0%)    3/28 (11%)  |1/36 (3%)    0/38 (0%)    1/35 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     611          708          676          585         |645          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.513N     P=0.615N     P=0.405N     P=0.556N    |P=0.287N     P=0.231N     P=0.501N     P=0.257N     |
|POLY 3             |     P=0.521N     P=0.558      P=0.350N     P=0.586N    |P=0.280N     P=0.236N     P=0.492N     P=0.248N     |
|POLY 1.5           |     P=0.528N     P=0.539      P=0.348N     P=0.598N    |P=0.277N     P=0.237N     P=0.494N     P=0.245N     |
|POLY 6             |     P=0.518N     P=0.579      P=0.355N     P=0.578N    |P=0.283N     P=0.236N     P=0.490N     P=0.251N     |
|LOGISTIC REGRESSION|     P=0.530N     P=0.592      P=0.354N     P=0.596N    |P=0.274N     P=0.238N     P=0.498N     P=0.237N     |
|COCH-ARM / FISHERS |     P=0.549N     P=0.500      P=0.357N     P=0.630N    |P=0.271N     P=0.247N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  9/50 (18%)   6/50 (12%)   8/50 (16%)  |3/50 (6%)    2/50 (4%)    4/50 (8%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     29.1%        20.5%        14.8%        18.6%       |6.7%         4.4%         8.6%         9.4%         |
|TERMINAL (d)       |     6/24 (25%)   6/30 (20%)   3/20 (15%)   6/28 (21%)  |1/36 (3%)    1/38 (3%)    3/35 (9%)    4/35 (11%)   |
|FIRST INCIDENCE    |     569          639          676          585         |645          652          468          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.252N     P=0.179N     P=0.159N     P=0.160N    |P=0.310      P=0.480N     P=0.505      P=0.474      |
|POLY 3             |     P=0.265N     P=0.250N     P=0.094N     P=0.187N    |P=0.311      P=0.498N     P=0.519      P=0.470      |
|POLY 1.5           |     P=0.267N     P=0.268N     P=0.090N     P=0.195N    |P=0.323      P=0.499N     P=0.513      P=0.480      |
|POLY 6             |     P=0.271N     P=0.235N     P=0.105N     P=0.188N    |P=0.300      P=0.497N     P=0.521      P=0.461      |
|LOGISTIC REGRESSION|     P=0.260N     P=0.232N     P=0.092N     P=0.183N    |P=0.347      P=0.501N     P=0.460      P=0.480      |
|COCH-ARM / FISHERS |     P=0.284N     P=0.312N     P=0.096N     P=0.227N    |P=0.345      P=0.500N     P=0.500      P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 33

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.5%         4.5%         2.2%         0.0%         |
|TERMINAL (d)       |                                                        |1/36 (3%)    2/38 (5%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |                                                        |645          730 (T)      625          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.154N     P=0.677N     P=0.493N     P=0.257N     |
|POLY 3             |                                                        |P=0.150N     P=0.693N     P=0.489N     P=0.248N     |
|POLY 1.5           |                                                        |P=0.148N     P=0.693N     P=0.493N     P=0.245N     |
|POLY 6             |                                                        |P=0.153N     P=0.692N     P=0.485N     P=0.251N     |
|LOGISTIC REGRESSION|                                                        |P=0.140N     P=0.693N     P=0.531N     P=0.237N     |
|COCH-ARM / FISHERS |                                                        |P=0.141N     P=0.691N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    7/50 (14%)   3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.7%         15.5%        6.4%         4.7%         |
|TERMINAL (d)       |                                                        |3/36 (8%)    6/38 (16%)   1/35 (3%)    1/35 (3%)    |
|FIRST INCIDENCE    |                                                        |730 (T)      666          575          639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.204N     P=0.182      P=0.659N     P=0.519N     |
|POLY 3             |                                                        |P=0.192N     P=0.163      P=0.640N     P=0.516N     |
|POLY 1.5           |                                                        |P=0.188N     P=0.160      P=0.648N     P=0.512N     |
|POLY 6             |                                                        |P=0.193N     P=0.167      P=0.631N     P=0.516N     |
|LOGISTIC REGRESSION|                                                        |P=0.187N     P=0.165      P=0.656      P=0.519N     |
|COCH-ARM / FISHERS |                                                        |P=0.178N     P=0.159      P=0.661N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 34

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         4.5%         6.5%         2.3%         |
|TERMINAL (d)       |                                                        |0/36 (0%)    2/38 (5%)    2/35 (6%)    1/35 (3%)    |
|FIRST INCIDENCE    |                                                        |---          730 (T)      536          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.599      P=0.250      P=0.121      P=0.494      |
|POLY 3             |                                                        |P=0.593      P=0.239      P=0.127      P=0.492      |
|POLY 1.5           |                                                        |P=0.601      P=0.238      P=0.124      P=0.494      |
|POLY 6             |                                                        |P=0.588      P=0.241      P=0.130      P=0.490      |
|LOGISTIC REGRESSION|                                                        |P=0.615      P=0.250      P=0.102      P=0.494      |
|COCH-ARM / FISHERS |                                                        |P=0.618      P=0.247      P=0.121      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  14/50 (28%)  13/50 (26%)  12/50 (24%) |10/50 (20%)  8/50 (16%)   8/50 (16%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     32.9%        31.5%        31.8%        27.3%       |22.3%        17.7%        17.2%        18.6%        |
|TERMINAL (d)       |     7/24 (29%)   9/30 (30%)   8/20 (40%)   8/28 (29%)  |8/36 (22%)   7/38 (18%)   5/35 (14%)   7/35 (20%)   |
|FIRST INCIDENCE    |     512          603          602          529         |665          633          662          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.301N     P=0.381N     P=0.543      P=0.299N    |P=0.481N     P=0.354N     P=0.396N     P=0.427N     |
|POLY 3             |     P=0.325N     P=0.533N     P=0.549N     P=0.367N    |P=0.472N     P=0.388N     P=0.365N     P=0.435N     |
|POLY 1.5           |     P=0.327N     P=0.546N     P=0.515N     P=0.370N    |P=0.459N     P=0.393N     P=0.377N     P=0.424N     |
|POLY 6             |     P=0.341N     P=0.528N     P=0.583      P=0.382N    |P=0.483N     P=0.382N     P=0.352N     P=0.443N     |
|LOGISTIC REGRESSION|     P=0.324N     P=0.526N     P=0.489N     P=0.385N    |P=0.480N     P=0.382N     P=0.366N     P=0.441N     |
|COCH-ARM / FISHERS |     P=0.356N     P=0.588N     P=0.500N     P=0.410N    |P=0.427N     P=0.398N     P=0.398N     P=0.398N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 35

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Cytoplasmic Alteration                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.0%         4.6%         0.0%         2.4%        |0.0%         0.0%         2.2%         2.3%         |
|TERMINAL (d)       |     1/24 (4%)    1/30 (3%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    1/35 (3%)    1/35 (3%)    |
|FIRST INCIDENCE    |     648          639          ---          729 (T)     |---          ---          730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.397N     P=0.623N     P=0.253N     P=0.455N    |P=0.292      (e)          P=0.494      P=0.494      |
|POLY 3             |     P=0.402N     P=0.662N     P=0.236N     P=0.481N    |P=0.289      (e)          P=0.506      P=0.492      |
|POLY 1.5           |     P=0.403N     P=0.673N     P=0.235N     P=0.485N    |P=0.293      (e)          P=0.504      P=0.494      |
|POLY 6             |     P=0.403N     P=0.650N     P=0.241N     P=0.480N    |P=0.285      (e)          P=0.508      P=0.490      |
|LOGISTIC REGRESSION|     P=0.400N     P=0.682N     P=0.236N     P=0.478N    |(e)          (e)          P=0.494      P=0.494      |
|COCH-ARM / FISHERS |     P=0.408N     P=0.691N     P=0.247N     P=0.500N    |P=0.303      (e)          P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     7.5%         4.6%         0.0%         4.7%        |0.0%         2.2%         0.0%         2.3%         |
|TERMINAL (d)       |     1/24 (4%)    2/30 (7%)    0/20 (0%)    2/28 (7%)   |0/36 (0%)    1/38 (3%)    0/35 (0%)    1/35 (3%)    |
|FIRST INCIDENCE    |     674          729 (T)      ---          729 (T)     |---          730 (T)      ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.509N     P=0.418N     P=0.145N     P=0.444N    |P=0.452      P=0.511      (e)          P=0.494      |
|POLY 3             |     P=0.536N     P=0.462N     P=0.117N     P=0.474N    |P=0.453      P=0.502      (e)          P=0.492      |
|POLY 1.5           |     P=0.536N     P=0.475N     P=0.116N     P=0.480N    |P=0.456      P=0.501      (e)          P=0.494      |
|POLY 6             |     P=0.538N     P=0.450N     P=0.121N     P=0.473N    |P=0.451      P=0.503      (e)          P=0.490      |
|LOGISTIC REGRESSION|     P=0.528N     P=0.438N     P=0.121N     P=0.464N    |(e)          P=0.511      (e)          P=0.494      |
|COCH-ARM / FISHERS |     P=0.539N     P=0.500N     P=0.121N     P=0.500N    |P=0.464      P=0.500      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 36

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    4/50 (8%)    2/50 (4%)   |5/50 (10%)   2/50 (4%)    7/50 (14%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.5%         9.2%         9.9%         4.7%        |11.2%        4.5%         15.3%        7.0%         |
|TERMINAL (d)       |     1/24 (4%)    4/30 (13%)   3/20 (15%)   2/28 (7%)   |5/36 (14%)   2/38 (5%)    7/35 (20%)   3/35 (9%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      691          729 (T)     |730 (T)      730 (T)      730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.489N     P=0.250      P=0.143      P=0.554     |P=0.476N     P=0.194N     P=0.357      P=0.370N     |
|POLY 3             |     P=0.503N     P=0.206      P=0.181      P=0.522     |P=0.479N     P=0.212N     P=0.401      P=0.379N     |
|POLY 1.5           |     P=0.509N     P=0.197      P=0.183      P=0.517     |P=0.467N     P=0.214N     P=0.394      P=0.373N     |
|POLY 6             |     P=0.503N     P=0.217      P=0.176      P=0.525     |P=0.488N     P=0.208N     P=0.407      P=0.383N     |
|LOGISTIC REGRESSION|     P=0.513N     P=0.250      P=0.165      P=0.554     |P=0.476N     P=0.194N     P=0.357      P=0.370N     |
|COCH-ARM / FISHERS |     P=0.532N     P=0.181      P=0.181      P=0.500     |P=0.442N     P=0.218N     P=0.380      P=0.357N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         0.0%        |0.0%         2.2%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          549          ---         |---          451          ---          614          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.659N     (e)          P=0.220      (e)         |P=0.456      P=0.500      (e)          P=0.495      |
|POLY 3             |     P=0.669N     (e)          P=0.242      (e)         |P=0.455      P=0.505      (e)          P=0.493      |
|POLY 1.5           |     P=0.670N     (e)          P=0.242      (e)         |P=0.457      P=0.503      (e)          P=0.495      |
|POLY 6             |     P=0.672N     (e)          P=0.240      (e)         |P=0.455      P=0.508      (e)          P=0.493      |
|LOGISTIC REGRESSION|     P=0.697N     (e)          P=0.230      (e)         |P=0.619      P=0.538      (e)          P=0.537      |
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |P=0.464      P=0.500      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 37

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   6/50 (12%)   3/50 (6%)   |19/50 (38%)  17/49 (35%)  23/50 (46%)  21/50 (42%)  |
|POLY-3 ADJUSTED (b)|     17.5%        13.6%        14.8%        7.0%        |42.1%        38.4%        50.0%        47.7%        |
|TERMINAL (d)       |     5/24 (21%)   4/30 (13%)   3/20 (15%)   2/28 (7%)   |17/36 (47%)  15/37 (41%)  21/35 (60%)  19/35 (54%)  |
|FIRST INCIDENCE    |     682          617          691          633         |625          666          703          465          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.117N     P=0.355N     P=0.590N     P=0.116N    |P=0.232      P=0.374N     P=0.231      P=0.366      |
|POLY 3             |     P=0.117N     P=0.424N     P=0.491N     P=0.129N    |P=0.265      P=0.441N     P=0.291      P=0.374      |
|POLY 1.5           |     P=0.119N     P=0.451N     P=0.488N     P=0.137N    |P=0.282      P=0.445N     P=0.286      P=0.387      |
|POLY 6             |     P=0.119N     P=0.394N     P=0.501N     P=0.124N    |P=0.247      P=0.434N     P=0.289      P=0.361      |
|LOGISTIC REGRESSION|     P=0.118N     P=0.408N     P=0.518N     P=0.127N    |P=0.219      P=0.422N     P=0.333      P=0.346      |
|COCH-ARM / FISHERS |     P=0.130N     P=0.500N     P=0.500N     P=0.159N    |P=0.320      P=0.447N     P=0.272      P=0.419      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    8/50 (16%)   10/50 (20%)  6/50 (12%)  |4/50 (8%)    4/49 (8%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     5.0%         17.7%        23.9%        13.8%       |8.9%         9.1%         0.0%         7.0%         |
|TERMINAL (d)       |     1/24 (4%)    3/30 (10%)   5/20 (25%)   3/28 (11%)  |3/36 (8%)    4/37 (11%)   0/35 (0%)    1/35 (3%)    |
|FIRST INCIDENCE    |     640          512          549          569         |543          730 (T)      ---          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.467      P=0.088      P=0.012 *    P=0.175     |P=0.458N     P=0.632N     P=0.067N     P=0.519N     |
|POLY 3             |     P=0.475      P=0.068      P=0.015 *    P=0.159     |P=0.445N     P=0.629      P=0.058N     P=0.525N     |
|POLY 1.5           |     P=0.464      P=0.059      P=0.015 *    P=0.152     |P=0.441N     P=0.630      P=0.059N     P=0.518N     |
|POLY 6             |     P=0.478      P=0.080      P=0.015 *    P=0.165     |P=0.447N     P=0.629      P=0.057N     P=0.528N     |
|LOGISTIC REGRESSION|     P=0.424      P=0.042 *    P=0.016 *    P=0.139     |P=0.441N     P=0.635      P=0.067N     P=0.500N     |
|COCH-ARM / FISHERS |     P=0.425      P=0.046 *    P=0.014 *    P=0.134     |P=0.430N     P=0.631      P=0.059N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 38

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         4.9%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/37 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     613          ---          508          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.433N     P=0.490N     P=0.478      P=0.505N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.441N     P=0.484N     P=0.505      P=0.489N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.439N     P=0.489N     P=0.506      P=0.492N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.447N     P=0.479N     P=0.500      P=0.489N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.485N     P=0.540N     P=0.475      P=0.545N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.441N     P=0.500N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  17/50 (34%)  21/50 (42%)  15/50 (30%) |23/50 (46%)  28/49 (57%)  23/50 (46%)  24/50 (48%)  |
|POLY-3 ADJUSTED (b)|     36.7%        37.1%        48.1%        34.0%       |48.4%        60.9%        49.0%        54.0%        |
|TERMINAL (d)       |     10/24 (42%)  10/30 (33%)  10/20 (50%)  10/28 (36%) |17/36 (47%)  22/37 (60%)  19/35 (54%)  19/35 (54%)  |
|FIRST INCIDENCE    |     611          386          444          569         |414          403          575          511          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.358N     P=0.510N     P=0.089      P=0.433N    |P=0.542      P=0.271      P=0.557      P=0.442      |
|POLY 3             |     P=0.381N     P=0.572      P=0.194      P=0.489N    |P=0.523      P=0.154      P=0.557      P=0.371      |
|POLY 1.5           |     P=0.389N     P=0.518      P=0.181      P=0.516N    |P=0.535N     P=0.161      P=0.564      P=0.407      |
|POLY 6             |     P=0.387N     P=0.551N     P=0.204      P=0.468N    |P=0.499      P=0.157      P=0.555      P=0.352      |
|LOGISTIC REGRESSION|     P=0.397N     P=0.507      P=0.153      P=0.504N    |P=0.494N     P=0.182      P=0.576N     P=0.467      |
|COCH-ARM / FISHERS |     P=0.432N     P=0.415      P=0.149      P=0.586N    |P=0.436N     P=0.182      P=0.579N     P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 39

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Pseudocyst                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     14.5%        0.0%         0.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/24 (8%)    0/30 (0%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/37 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     597          ---          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.142N     P=0.014N*    P=0.026N*    P=0.054N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.138N     P=0.012N*    P=0.016N*    P=0.051N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.137N     P=0.013N*    P=0.015N*    P=0.051N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.140N     P=0.012N*    P=0.018N*    P=0.053N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.141N     P=0.019N*    P=0.018N*    P=0.058N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.139N     P=0.013N*    P=0.013N*    P=0.056N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Pseudocyst                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/37 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     313          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.152N     P=0.112N     P=0.126N     P=0.121N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.150N     P=0.109N     P=0.123N     P=0.113N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.149N     P=0.112N     P=0.120N     P=0.114N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.153N     P=0.106N     P=0.128N     P=0.114N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.213N     P=0.197N     P=0.164N     P=0.218N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.149N     P=0.121N     P=0.121N     P=0.121N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 40

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    4/50 (8%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         9.8%         4.7%        |                                                    |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    2/20 (10%)   2/28 (7%)   |                                                    |
|FIRST INCIDENCE    |     ---          ---          523          729 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.244      (e)          P=0.051      P=0.272     |                                                    |
|POLY 3             |     P=0.220      (e)          P=0.063      P=0.251     |                                                    |
|POLY 1.5           |     P=0.220      (e)          P=0.063      P=0.248     |                                                    |
|POLY 6             |     P=0.215      (e)          P=0.061      P=0.253     |                                                    |
|LOGISTIC REGRESSION|     P=0.221      (e)          P=0.064      P=0.272     |                                                    |
|COCH-ARM / FISHERS |     P=0.213      (e)          P=0.059      P=0.247     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     46/50 (92%)  45/50 (90%)  48/50 (96%)  48/50 (96%) |                                                    |
|POLY-3 ADJUSTED (b)|     96.2%        91.7%        99.2%        98.2%       |                                                    |
|TERMINAL (d)       |     23/24 (96%)  28/30 (93%)  20/20 (100%) 28/28 (100%)|                                                    |
|FIRST INCIDENCE    |     313          386          482          490         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.526N     P=0.105N     P=0.227      P=0.363N    |                                                    |
|POLY 3             |     P=0.188      P=0.287N     P=0.364      P=0.510     |                                                    |
|POLY 1.5           |     P=0.209      P=0.334N     P=0.357      P=0.467     |                                                    |
|POLY 6             |     P=0.155      P=0.293N     P=0.388      P=0.494     |                                                    |
|LOGISTIC REGRESSION|     P=0.365      P=0.354N     P=0.571      P=0.681     |                                                    |
|COCH-ARM / FISHERS |     P=0.210      P=0.500N     P=0.339      P=0.339     |                                                    |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 41

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    2/50 (4%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         6.9%         5.0%         4.7%        |                                                    |
|TERMINAL (d)       |     0/24 (0%)    3/30 (10%)   0/20 (0%)    1/28 (4%)   |                                                    |
|FIRST INCIDENCE    |     ---          729 (T)      715          569         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.488      P=0.162      P=0.204      P=0.262     |                                                    |
|POLY 3             |     P=0.496      P=0.135      P=0.239      P=0.254     |                                                    |
|POLY 1.5           |     P=0.487      P=0.129      P=0.240      P=0.249     |                                                    |
|POLY 6             |     P=0.503      P=0.141      P=0.236      P=0.258     |                                                    |
|LOGISTIC REGRESSION|     P=0.472      P=0.162      P=0.229      P=0.217     |                                                    |
|COCH-ARM / FISHERS |     P=0.461      P=0.121      P=0.247      P=0.247     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     27/50 (54%)  38/50 (76%)  31/50 (62%)  29/50 (58%) |                                                    |
|POLY-3 ADJUSTED (b)|     61.2%        77.7%        67.8%        60.3%       |                                                    |
|TERMINAL (d)       |     15/24 (63%)  21/30 (70%)  12/20 (60%)  13/28 (46%) |                                                    |
|FIRST INCIDENCE    |     361          386          482          490         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.272N     P=0.259      P=0.191      P=0.503N    |                                                    |
|POLY 3             |     P=0.172N     P=0.060      P=0.329      P=0.550N    |                                                    |
|POLY 1.5           |     P=0.209N     P=0.040 *    P=0.316      P=0.558     |                                                    |
|POLY 6             |     P=0.147N     P=0.084      P=0.333      P=0.503N    |                                                    |
|LOGISTIC REGRESSION|     P=0.301N     P=0.025 *    P=0.291      P=0.440     |                                                    |
|COCH-ARM / FISHERS |     P=0.313N     P=0.018 *    P=0.272      P=0.420     |                                                    |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 42

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         2.5%         0.0%        |2.2%         2.2%         4.4%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    1/38 (3%)    1/35 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          523          ---         |501          730 (T)      703          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.447N     P=0.455N     P=0.745      P=0.469N    |P=0.346N     P=0.757N     P=0.508      P=0.508N     |
|POLY 3             |     P=0.468N     P=0.482N     P=0.756N     P=0.487N    |P=0.353N     P=0.759      P=0.506      P=0.511N     |
|POLY 1.5           |     P=0.465N     P=0.488N     P=0.756N     P=0.491N    |P=0.347N     P=0.759      P=0.504      P=0.508N     |
|POLY 6             |     P=0.473N     P=0.476N     P=0.758N     P=0.486N    |P=0.357N     P=0.760      P=0.508      P=0.514N     |
|LOGISTIC REGRESSION|     P=0.493N     (e)          P=0.753      (e)         |P=0.310N     P=0.764N     P=0.445      P=0.377N     |
|COCH-ARM / FISHERS |     P=0.464N     P=0.500N     P=0.753N     P=0.500N    |P=0.333N     P=0.753N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Cytoplasmic Alteration                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         4.7%        |2.2%         2.2%         2.2%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    2/28 (7%)   |1/36 (3%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     611          ---          ---          729 (T)     |730 (T)      540          687          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199      P=0.495N     P=0.515N     P=0.530     |P=0.336N     P=0.754N     P=0.755N     P=0.506N     |
|POLY 3             |     P=0.184      P=0.484N     P=0.500N     P=0.518     |P=0.336N     P=0.756N     P=0.753N     P=0.508N     |
|POLY 1.5           |     P=0.186      P=0.489N     P=0.498N     P=0.515     |P=0.332N     P=0.758N     P=0.756N     P=0.506N     |
|POLY 6             |     P=0.181      P=0.479N     P=0.505N     P=0.519     |P=0.338N     P=0.753N     P=0.750N     P=0.510N     |
|LOGISTIC REGRESSION|     P=0.190      P=0.541N     P=0.517N     P=0.516     |P=0.292N     P=0.764N     P=0.759N     (e)          |
|COCH-ARM / FISHERS |     P=0.186      P=0.500N     P=0.500N     P=0.500     |P=0.323N     P=0.753N     P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 43

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    2/34 (6%)    |
|FIRST INCIDENCE    |     682          729 (T)      ---          ---         |---          ---          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.320N     P=0.719N     P=0.500N     P=0.488N    |P=0.036 *    (e)          (e)          P=0.226      |
|POLY 3             |     P=0.321N     P=0.742N     P=0.499N     P=0.488N    |P=0.036 *    (e)          (e)          P=0.223      |
|POLY 1.5           |     P=0.322N     P=0.748N     P=0.498N     P=0.491N    |P=0.037 *    (e)          (e)          P=0.226      |
|POLY 6             |     P=0.321N     P=0.735N     P=0.503N     P=0.488N    |P=0.036 *    (e)          (e)          P=0.220      |
|LOGISTIC REGRESSION|     P=0.320N     P=0.741N     P=0.498N     P=0.494N    |(e)          (e)          (e)          P=0.226      |
|COCH-ARM / FISHERS |     P=0.325N     P=0.753N     P=0.500N     P=0.500N    |P=0.040 *    (e)          (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Accessory Spleen                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.3%         0.0%         4.7%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     1/24 (4%)    1/30 (3%)    0/20 (0%)    1/28 (4%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          691         |---          ---          708          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.352      P=0.712N     P=0.536N     P=0.555     |P=0.798N     (e)          P=0.511      (e)          |
|POLY 3             |     P=0.334      P=0.741N     P=0.498N     P=0.523     |P=0.793N     (e)          P=0.507      (e)          |
|POLY 1.5           |     P=0.332      P=0.748N     P=0.497N     P=0.517     |P=0.791N     (e)          P=0.504      (e)          |
|POLY 6             |     P=0.333      P=0.733N     P=0.501N     P=0.528     |P=0.794N     (e)          P=0.509      (e)          |
|LOGISTIC REGRESSION|     P=0.334      P=0.712N     (e)          P=0.528     |P=0.793N     (e)          P=0.504      (e)          |
|COCH-ARM / FISHERS |     P=0.325      P=0.753N     P=0.500N     P=0.500     |P=0.786N     (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 44

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    4/50 (8%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.0%         9.2%         9.9%         11.7%       |0.0%         0.0%         4.4%         2.3%         |
|TERMINAL (d)       |     1/24 (4%)    4/30 (13%)   2/20 (10%)   3/28 (11%)  |0/36 (0%)    0/38 (0%)    2/35 (6%)    1/35 (3%)    |
|FIRST INCIDENCE    |     718          729 (T)      682          632         |---          ---          730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.288      P=0.436      P=0.276      P=0.272     |P=0.336      (e)          P=0.232      P=0.494      |
|POLY 3             |     P=0.270      P=0.378      P=0.342      P=0.244     |P=0.329      (e)          P=0.244      P=0.492      |
|POLY 1.5           |     P=0.265      P=0.364      P=0.344      P=0.237     |P=0.336      (e)          P=0.242      P=0.494      |
|POLY 6             |     P=0.271      P=0.393      P=0.336      P=0.250     |P=0.324      (e)          P=0.246      P=0.490      |
|LOGISTIC REGRESSION|     P=0.257      P=0.421      P=0.323      P=0.245     |(e)          (e)          P=0.232      P=0.494      |
|COCH-ARM / FISHERS |     P=0.246      P=0.339      P=0.339      P=0.218     |P=0.350      (e)          P=0.247      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   3/50 (6%)    5/50 (10%)  |3/50 (6%)    4/50 (8%)    7/50 (14%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     9.7%         10.9%        7.2%         11.3%       |6.6%         8.4%         15.2%        4.6%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    4/35 (11%)   1/35 (3%)    |
|FIRST INCIDENCE    |     597          410          523          537         |429          403          703          584          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.480      P=0.547      P=0.504N     P=0.523     |P=0.365N     P=0.505      P=0.175      P=0.524N     |
|POLY 3             |     P=0.497      P=0.564      P=0.491N     P=0.545     |P=0.383N     P=0.521      P=0.160      P=0.527N     |
|POLY 1.5           |     P=0.493      P=0.543      P=0.489N     P=0.533     |P=0.365N     P=0.514      P=0.160      P=0.519N     |
|POLY 6             |     P=0.496      P=0.584      P=0.502N     P=0.551     |P=0.397N     P=0.528      P=0.160      P=0.533N     |
|LOGISTIC REGRESSION|     P=0.310      P=0.349      P=0.574N     P=0.377     |P=0.215N     P=0.512      P=0.140      P=0.422N     |
|COCH-ARM / FISHERS |     P=0.474      P=0.500      P=0.500N     P=0.500     |P=0.328N     P=0.500      P=0.159      P=0.500N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 45

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |25/50 (50%)  26/50 (52%)  28/50 (56%)  32/50 (64%)  |
|POLY-3 ADJUSTED (b)|     2.5%         4.6%         4.8%         2.4%        |53.6%        56.9%        58.7%        69.0%        |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    1/28 (4%)   |19/36 (53%)  24/38 (63%)  22/35 (63%)  26/35 (74%)  |
|FIRST INCIDENCE    |     361          687          482          729 (T)     |414          540          468          347          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.500N     P=0.561      P=0.517      P=0.739N    |P=0.048 *    P=0.559N     P=0.337      P=0.098      |
|POLY 3             |     P=0.513N     P=0.526      P=0.507      P=0.752N    |P=0.070      P=0.457      P=0.387      P=0.090      |
|POLY 1.5           |     P=0.513N     P=0.516      P=0.507      P=0.753N    |P=0.073      P=0.472      P=0.374      P=0.097      |
|POLY 6             |     P=0.516N     P=0.538      P=0.506      P=0.751N    |P=0.064      P=0.437      P=0.393      P=0.080      |
|LOGISTIC REGRESSION|     P=0.657N     P=0.390      P=0.242      P=0.648     |P=0.056      P=0.516      P=0.371      P=0.096      |
|COCH-ARM / FISHERS |     P=0.521N     P=0.500      P=0.500      P=0.753N    |P=0.081      P=0.500      P=0.344      P=0.113      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         7.2%         4.6%        |0.0%         2.2%         2.1%         6.8%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     454          ---          482          490         |---          652          468          414          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.488      P=0.215N     P=0.474      P=0.655N    |P=0.056      P=0.509      P=0.508      P=0.116      |
|POLY 3             |     P=0.469      P=0.222N     P=0.510      P=0.672N    |P=0.063      P=0.503      P=0.509      P=0.118      |
|POLY 1.5           |     P=0.469      P=0.227N     P=0.509      P=0.677N    |P=0.063      P=0.502      P=0.506      P=0.118      |
|POLY 6             |     P=0.464      P=0.216N     P=0.507      P=0.669N    |P=0.063      P=0.506      P=0.512      P=0.119      |
|LOGISTIC REGRESSION|     P=0.347      P=0.291N     P=0.437      P=0.598     |P=0.165      P=0.500      P=0.255      P=0.189      |
|COCH-ARM / FISHERS |     P=0.461      P=0.247N     P=0.500      P=0.691N    |P=0.064      P=0.500      P=0.500      P=0.121      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 46

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.0%         4.5%         2.5%         0.0%        |2.2%         2.2%         2.2%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |1/36 (3%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     648          512          585          ---         |730 (T)      666          526          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.150N     P=0.645N     P=0.522N     P=0.223N    |P=0.654      P=0.746N     P=0.759N     P=0.757      |
|POLY 3             |     P=0.145N     P=0.659N     P=0.496N     P=0.225N    |P=0.656      P=0.757N     P=0.751N     P=0.756      |
|POLY 1.5           |     P=0.145N     P=0.671N     P=0.494N     P=0.228N    |P=0.660      P=0.759N     P=0.754N     P=0.757      |
|POLY 6             |     P=0.147N     P=0.647N     P=0.501N     P=0.224N    |P=0.653      P=0.755N     P=0.747N     P=0.755      |
|LOGISTIC REGRESSION|     P=0.163N     P=0.671      P=0.505N     P=0.230N    |P=0.497N     P=0.762N     P=0.721      P=0.662N     |
|COCH-ARM / FISHERS |     P=0.148N     P=0.691N     P=0.500N     P=0.247N    |P=0.667      P=0.753N     P=0.753N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         0.0%         7.4%         4.7%        |0.0%         0.0%         4.3%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     648          ---          653          676         |---          ---          526          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.470      P=0.205N     P=0.482      P=0.658N    |P=0.711N     (e)          P=0.250      (e)          |
|POLY 3             |     P=0.465      P=0.219N     P=0.505      P=0.672N    |P=0.713N     (e)          P=0.248      (e)          |
|POLY 1.5           |     P=0.467      P=0.225N     P=0.507      P=0.677N    |P=0.709N     (e)          P=0.244      (e)          |
|POLY 6             |     P=0.460      P=0.214N     P=0.499      P=0.669N    |P=0.717N     (e)          P=0.252      (e)          |
|LOGISTIC REGRESSION|     P=0.469      P=0.229N     P=0.504      P=0.683N    |P=0.636N     (e)          P=0.176      (e)          |
|COCH-ARM / FISHERS |     P=0.461      P=0.247N     P=0.500      P=0.691N    |P=0.697N     (e)          P=0.247      (e)          |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 47

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    3/50 (6%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     5.0%         2.3%         9.7%         6.9%        |4.5%         2.2%         0.0%         7.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    2/35 (6%)    |
|FIRST INCIDENCE    |     674          663          585          529         |656          680          ---          639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.365      P=0.449N     P=0.323      P=0.543     |P=0.232      P=0.497N     P=0.227N     P=0.473      |
|POLY 3             |     P=0.373      P=0.469N     P=0.350      P=0.536     |P=0.244      P=0.498N     P=0.232N     P=0.480      |
|POLY 1.5           |     P=0.370      P=0.480N     P=0.348      P=0.526     |P=0.248      P=0.499N     P=0.234N     P=0.486      |
|POLY 6             |     P=0.372      P=0.458N     P=0.348      P=0.544     |P=0.241      P=0.497N     P=0.232N     P=0.476      |
|LOGISTIC REGRESSION|     P=0.336      P=0.487N     P=0.338      P=0.484     |P=0.261      P=0.501N     P=0.249N     P=0.497      |
|COCH-ARM / FISHERS |     P=0.354      P=0.500N     P=0.339      P=0.500     |P=0.256      P=0.500N     P=0.247N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    4/50 (8%)    2/50 (4%)   |3/50 (6%)    1/50 (2%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         4.6%         9.6%         4.7%        |6.5%         2.2%         6.4%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    1/30 (3%)    0/20 (0%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     368          709          508          569         |501          666          526          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.559N     P=0.638N     P=0.326      P=0.664N    |P=0.157N     P=0.306N     P=0.633N     P=0.132N     |
|POLY 3             |     P=0.570N     P=0.671N     P=0.343      P=0.676N    |P=0.161N     P=0.311N     P=0.652N     P=0.132N     |
|POLY 1.5           |     P=0.571N     P=0.679N     P=0.344      P=0.680N    |P=0.155N     P=0.309N     P=0.655N     P=0.128N     |
|POLY 6             |     P=0.572N     P=0.662N     P=0.340      P=0.674N    |P=0.167N     P=0.312N     P=0.649N     P=0.136N     |
|LOGISTIC REGRESSION|     P=0.590      P=0.640      P=0.276      P=0.573     |P=0.090N     P=0.295N     P=0.543      P=0.069N     |
|COCH-ARM / FISHERS |     P=0.582N     P=0.691N     P=0.339      P=0.691N    |P=0.144N     P=0.309N     P=0.661N     P=0.121N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 48

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   3/50 (6%)    6/50 (12%)  |                                                    |
|POLY-3 ADJUSTED (b)|     12.1%        15.8%        7.3%         13.9%       |                                                    |
|TERMINAL (d)       |     2/24 (8%)    4/30 (13%)   0/20 (0%)    3/28 (11%)  |                                                    |
|FIRST INCIDENCE    |     361          585          562          562         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.560      P=0.499      P=0.397N     P=0.574     |                                                    |
|POLY 3             |     P=0.542      P=0.428      P=0.356N     P=0.531     |                                                    |
|POLY 1.5           |     P=0.539      P=0.411      P=0.353N     P=0.524     |                                                    |
|POLY 6             |     P=0.539      P=0.448      P=0.364N     P=0.534     |                                                    |
|LOGISTIC REGRESSION|     P=0.514      P=0.364      P=0.386N     P=0.476     |                                                    |
|COCH-ARM / FISHERS |     P=0.524      P=0.380      P=0.357N     P=0.500     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     28/50 (56%)  37/50 (74%)  28/50 (56%)  24/50 (48%) |                                                    |
|POLY-3 ADJUSTED (b)|     57.6%        76.8%        58.1%        49.6%       |                                                    |
|TERMINAL (d)       |     6/24 (25%)   23/30 (77%)  10/20 (50%)  9/28 (32%)  |                                                    |
|FIRST INCIDENCE    |     312          386          400          490         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.083N     P=0.350      P=0.466      P=0.226N    |                                                    |
|POLY 3             |     P=0.042N*    P=0.032 *    P=0.560      P=0.281N    |                                                    |
|POLY 1.5           |     P=0.043N*    P=0.039 *    P=0.578      P=0.271N    |                                                    |
|POLY 6             |     P=0.045N*    P=0.023 *    P=0.520      P=0.305N    |                                                    |
|LOGISTIC REGRESSION|     P=0.055N     P=0.022 *    P=0.584N     P=0.379N    |                                                    |
|COCH-ARM / FISHERS |     P=0.049N*    P=0.046 *    P=0.580N     P=0.274N    |                                                    |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 49

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     44/46 (96%)  45/47 (96%)  40/46 (87%)  43/47 (91%) |46/46 (100%) 46/48 (96%)  47/50 (94%)  48/48 (100%) |
|POLY-3 ADJUSTED (b)|     95.7%        96.5%        91.2%        94.1%       |100.0%       96.1%        95.1%        100.0%       |
|TERMINAL (d)       |     22/23 (96%)  28/28 (100%) 16/17 (94%)  26/27 (96%) |34/34 (100%) 35/36 (97%)  34/35 (97%)  35/35 (100%) |
|FIRST INCIDENCE    |     312          386          482          490         |414          403          468          309          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.268N     P=0.199N     P=0.447      P=0.214N    |P=0.320      P=0.402N     P=0.536N     (e)          |
|POLY 3             |     P=0.449N     P=0.644      P=0.316N     P=0.547N    |P=0.384      P=0.267N     P=0.170N     (e)          |
|POLY 1.5           |     P=0.378N     P=0.664      P=0.224N     P=0.455N    |P=0.378      P=0.256N     P=0.151N     (e)          |
|POLY 6             |     P=0.549N     P=0.610      P=0.436N     P=0.664N    |P=0.398      P=0.288N     P=0.218N     (e)          |
|LOGISTIC REGRESSION|     P=0.263N     P=0.663      P=0.123N     P=0.328N    |P=0.369      P=0.245N     P=0.127N     (e)          |
|COCH-ARM / FISHERS |     P=0.305N     P=0.683      P=0.133N     P=0.349N    |P=0.374      P=0.258N     P=0.137N     (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     19/50 (38%)  30/50 (60%)  26/50 (52%)  20/50 (40%) |35/50 (70%)  38/50 (76%)  34/50 (68%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     46.0%        67.5%        60.0%        44.3%       |76.8%        82.7%        71.0%        53.5%        |
|TERMINAL (d)       |     12/24 (50%)  23/30 (77%)  14/20 (70%)  12/28 (43%) |32/36 (89%)  35/38 (92%)  27/35 (77%)  22/35 (63%)  |
|FIRST INCIDENCE    |     640          663          508          529         |575          540          526          639          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.162N     P=0.168      P=0.057      P=0.470N    |P<0.001N**   P=0.485      P=0.544N     P=0.008N**   |
|POLY 3             |     P=0.101N     P=0.029 *    P=0.132      P=0.523N    |P<0.001N**   P=0.317      P=0.336N     P=0.013N*    |
|POLY 1.5           |     P=0.133N     P=0.027 *    P=0.131      P=0.564N    |P<0.001N**   P=0.317      P=0.401N     P=0.012N*    |
|POLY 6             |     P=0.081N     P=0.031 *    P=0.123      P=0.498N    |P<0.001N**   P=0.321      P=0.264N     P=0.013N*    |
|LOGISTIC REGRESSION|     P=0.171N     P=0.062      P=0.106      P=0.572N    |P<0.001N**   P=0.365      P=0.385N     P=0.013N*    |
|COCH-ARM / FISHERS |     P=0.223N     P=0.022 *    P=0.114      P=0.500     |P<0.001N**   P=0.326      P=0.500N     P=0.013N*    |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 50

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         7.5%         0.0%        |2.2%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    3/20 (15%)   0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |665          652          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.592N     (e)          P=0.089      (e)         |P=0.320N     P=0.750N     P=0.481N     P=0.516N     |
|POLY 3             |     P=0.609N     (e)          P=0.119      (e)         |P=0.307N     P=0.758N     P=0.495N     P=0.509N     |
|POLY 1.5           |     P=0.609N     (e)          P=0.121      (e)         |P=0.306N     P=0.759N     P=0.497N     P=0.507N     |
|POLY 6             |     P=0.614N     (e)          P=0.116      (e)         |P=0.308N     P=0.757N     P=0.494N     P=0.512N     |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.089      (e)         |P=0.283N     P=0.762      P=0.519N     P=0.491N     |
|COCH-ARM / FISHERS |     P=0.617N     (e)          P=0.121      (e)         |P=0.303N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth: Peridontal Tissue                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/1 (100%)   0/0 (0%)     0/1 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     3/4 (75%)    |
|POLY-3 ADJUSTED (b)|     100.0%       0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         80.3%        |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     3/3 (100%)   |
|FIRST INCIDENCE    |     723          ---          ---          ---         |---          ---          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=1.000      (e)          P=1.000N     (e)         |P=1.000N     (e)          (e)          P=1.000N     |
|POLY 3             |     (e)          (e)          P=1.000N     (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          P=1.000N     (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          P=1.000N     (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=1.000N     |
|COCH-ARM / FISHERS |     P=0.970N     (e)          P=0.500N     (e)         |P=1.000N     (e)          (e)          P=1.000      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 51

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          721          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.652N     (e)          P=0.207      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.670N     (e)          P=0.239      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.670N     (e)          P=0.240      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.673N     (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.667N     (e)          P=0.221      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.9%         0.0%        |2.2%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/24 (0%)    0/30 (0%)    1/20 (5%)    0/28 (0%)   |0/36 (0%)    0/38 (0%)    0/35 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          537          ---         |656          ---          ---          414          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.656N     (e)          P=0.222      (e)         |P=0.520      P=0.495N     P=0.486N     P=0.745      |
|POLY 3             |     P=0.669N     (e)          P=0.242      (e)         |P=0.529      P=0.499N     P=0.495N     P=0.754      |
|POLY 1.5           |     P=0.669N     (e)          P=0.242      (e)         |P=0.532      P=0.500N     P=0.497N     P=0.756      |
|POLY 6             |     P=0.672N     (e)          P=0.240      (e)         |P=0.527      P=0.499N     P=0.494N     P=0.753      |
|LOGISTIC REGRESSION|     P=0.702N     (e)          P=0.227      (e)         |P=0.681      P=0.501N     P=0.524N     P=0.675N     |
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |P=0.536      P=0.500N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 52

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.5%         0.0%         8.7%         0.0%         |
|TERMINAL (d)       |                                                        |1/36 (3%)    0/38 (0%)    4/35 (11%)   0/35 (0%)    |
|FIRST INCIDENCE    |                                                        |694          ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.320N     P=0.237N     P=0.331      P=0.249N     |
|POLY 3             |                                                        |P=0.325N     P=0.236N     P=0.350      P=0.247N     |
|POLY 1.5           |                                                        |P=0.318N     P=0.237N     P=0.346      P=0.244N     |
|POLY 6             |                                                        |P=0.332N     P=0.234N     P=0.353      P=0.250N     |
|LOGISTIC REGRESSION|                                                        |P=0.322N     P=0.235N     P=0.356      P=0.246N     |
|COCH-ARM / FISHERS |                                                        |P=0.304N     P=0.247N     P=0.339      P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus: Cervix                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.2%         0.0%         2.2%         4.7%         |
|TERMINAL (d)       |                                                        |1/36 (3%)    0/38 (0%)    1/35 (3%)    2/35 (6%)    |
|FIRST INCIDENCE    |                                                        |730 (T)      ---          730 (T)      730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.217      P=0.489N     P=0.756      P=0.490      |
|POLY 3             |                                                        |P=0.219      P=0.498N     P=0.754N     P=0.485      |
|POLY 1.5           |                                                        |P=0.223      P=0.499N     P=0.756N     P=0.489      |
|POLY 6             |                                                        |P=0.215      P=0.497N     P=0.752N     P=0.483      |
|LOGISTIC REGRESSION|                                                        |P=0.217      (e)          P=0.756      P=0.490      |
|COCH-ARM / FISHERS |                                                        |P=0.231      P=0.500N     P=0.753N     P=0.500      |
|=================================================================================================================================|
       Date:  10/27/99                           EXPERIMENT: 88120 TEST: 03                                            Page 53

Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus: Endometrium                                                                                                              |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    7/50 (14%)   7/50 (14%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|                                                        |6.7%         15.5%        15.0%        14.1%        |
|TERMINAL (d)       |                                                        |2/36 (6%)    6/38 (16%)   4/35 (11%)   6/35 (17%)   |
|FIRST INCIDENCE    |                                                        |660          690          625          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.356      P=0.181      P=0.172      P=0.225      |
|POLY 3             |                                                        |P=0.352      P=0.160      P=0.174      P=0.218      |
|POLY 1.5           |                                                        |P=0.366      P=0.159      P=0.168      P=0.226      |
|POLY 6             |                                                        |P=0.339      P=0.161      P=0.181      P=0.211      |
|LOGISTIC REGRESSION|                                                        |P=0.353      P=0.163      P=0.162      P=0.216      |
|COCH-ARM / FISHERS |                                                        |P=0.397      P=0.159      P=0.159      P=0.243      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        10 PPM       30 PPM       100 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Vagina                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/0 (0%)     2/2 (100%)   0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         100.0%       0.0%         0.0%         |
|TERMINAL (d)       |                                                        |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |                                                        |---          403          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |(e)          (e)          (e)          (e)          |
|POLY 3             |                                                        |(e)          (e)          (e)          (e)          |
|POLY 1.5           |                                                        |(e)          (e)          (e)          (e)          |
|POLY 6             |                                                        |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|                                                        |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |                                                        |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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