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TDMS Study 88120-04 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                           P,P'-DICHLORODIPHENYL SULFONE                                    DATE: 09/24/99    
EXPERIMENT: 88120 TEST: 04                                                                                        TIME: 08:17:36    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C88120B     
CONT: NO1-ES-55388                                                                                                CAS: 80-07-9      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE COLUMBUS LABORATORY                     P,P'-DICHLORODIPHENYL SULFONE                               DATE: 09/24/99


EXPERIMENT: 88120 TEST: 04                                                                                        TIME:  8:27:33



TEST TYPE: TWO YEAR                                 ROUTE: DOSED FEED                                             NTP:  88120B

CONT: NO1-ES-55388                                                                                                CAS: 80-07-9

                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
                        TWO YEAR DOSED FEED STUDY OF P,P'-DICHLORODIPHENYL SULFONE

==========================================================================================================
WEEK     0 PPM                  30 PPM                   100 PPM                  300 PPM
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        20.4       50        20.4    100.0    50      20.4    100.0    50      20.4    100.0    50
  1        20.4       50        20.4    100.0    50      20.4    100.0    50      20.4    100.0    50
  2        20.8       50        20.6     99.0    50      20.7     99.5    50      20.4     98.1    50
  6        26.2       49        25.3     96.6    50      25.6     97.7    49      24.4     93.1    49
 10        28.4       49        28.3     99.6    49      28.2     99.3    49      27.1     95.4    49
 14        32.1       49        32.1    100.0    49      32.1    100.0    49      30.2     94.1    49
 18        35.6       49        34.6     97.2    49      34.6     97.2    49      33.0     92.7    49
 22        39.0       49        37.3     95.6    49      37.0     94.9    49      35.5     91.0    49
 26        41.2       49        39.1     94.9    49      38.9     94.4    49      36.3     88.1    49
 30        42.3       49        39.5     93.4    49      38.9     92.0    49      37.0     87.5    49
 34        43.7       49        41.8     95.7    49      40.9     93.6    49      39.2     89.7    49
 38        44.5       49        42.4     95.3    49      42.1     94.6    49      39.7     89.2    49
 42        44.7       49        42.4     94.9    49      42.2     94.4    49      40.0     89.5    49
 46        46.0       49        43.4     94.3    49      42.2     91.7    49      41.1     89.3    49
 50        45.8       49        43.5     95.0    49      42.8     93.4    49      40.9     89.3    49
 54        46.2       49        44.2     95.7    49      43.4     93.9    49      41.2     89.2    48
 58        46.9       49        45.1     96.2    49      44.2     94.2    49      42.1     89.8    47
 62        46.3       49        45.0     97.2    49      44.5     96.1    47      41.9     90.5    46
 66        46.0       49        45.0     97.8    49      44.2     96.1    47      41.6     90.4    46
 70        45.5       49        45.2     99.3    49      44.4     97.6    47      41.4     91.0    46
 74        46.2       49        45.9     99.4    49      44.4     96.1    47      42.5     92.0    45
 78        45.3       49        45.3    100.0    49      43.8     96.7    46      42.3     93.4    45
 82        44.0       48        44.0    100.0    48      42.7     97.0    46      41.4     94.1    45
 86        42.8       48        43.1    100.7    48      42.2     98.6    46      40.4     94.4    45
 90        40.9       47        41.4    101.2    48      41.2    100.7    46      38.7     94.6    44
 94        37.9       45        39.5    104.2    47      39.4    104.0    45      36.5     96.3    44
 98        37.4       43        38.0    101.6    47      37.7    100.8    45      35.2     94.1    44
102        36.5       41        37.4    102.5    47      36.5    100.0    44      34.6     94.8    43

TERM. SAC.            40                         45                       44                       42


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
                        TWO YEAR DOSED FEED STUDY OF P,P'-DICHLORODIPHENYL SULFONE

==========================================================================================================
WEEK     0 PPM                  30 PPM                   100 PPM                  300 PPM
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        17.2       50        17.5    101.7    50      17.3    100.6    50      17.2    100.0    50
  1        17.2       50        17.5    101.7    50      17.3    100.6    50      17.2    100.0    50
  2        17.2       50        17.3    100.6    50      17.3    100.6    50      16.9     98.3    50
  6        21.2       50        21.5    101.4    50      21.1     99.5    50      20.3     95.8    50
 10        23.0       50        23.5    102.2    50      23.6    102.6    50      22.5     97.8    50
 14        25.5       50        26.8    105.1    50      26.7    104.7    50      24.3     95.3    50
 18        29.6       50        30.4    102.7    50      29.8    100.7    50      27.0     91.2    50
 22        32.0       50        34.3    107.2    50      32.7    102.2    50      29.5     92.2    50
 26        36.0       50        36.9    102.5    50      34.6     96.1    50      31.5     87.5    50
 30        37.1       50        38.6    104.0    50      36.1     97.3    50      32.5     87.6    50
 34        39.0       50        40.1    102.8    50      38.3     98.2    50      35.3     90.5    50
 38        40.3       50        41.1    102.0    50      39.5     98.0    50      35.5     88.1    50
 42        42.1       50        42.8    101.7    50      41.5     98.6    50      37.6     89.3    50
 46        42.4       50        43.4    102.4    50      40.5     95.5    50      37.6     88.7    50
 50        43.0       50        43.7    101.6    50      41.2     95.8    50      38.2     88.8    50
 54        43.4       50        44.9    103.5    50      42.5     97.9    50      38.7     89.2    50
 58        44.7       50        46.4    103.8    50      44.1     98.7    50      40.6     90.8    50
 62        45.1       50        47.0    104.2    50      44.4     98.4    50      39.9     88.5    50
 66        44.9       50        46.8    104.2    50      43.8     97.6    50      39.3     87.5    50
 70        44.8       50        47.0    104.9    50      43.7     97.5    50      40.1     89.5    50
 74        46.5       49        48.6    104.5    48      45.8     98.5    50      42.0     90.3    50
 78        46.0       49        47.9    104.1    48      45.2     98.3    50      41.2     89.6    50
 82        45.7       49        48.7    106.6    47      45.0     98.5    50      41.1     89.9    50
 86        44.4       48        46.9    105.6    46      43.6     98.2    49      39.5     89.0    49
 90        43.4       47        44.9    103.5    44      42.0     96.8    49      38.5     88.7    49
 94        42.9       45        43.8    102.1    44      40.2     93.7    48      37.5     87.4    49
 98        43.7       44        44.5    101.8    43      41.0     93.8    48      37.7     86.3    49
102        43.0       43        44.3    103.0    41      40.3     93.7    46      37.3     86.7    47

TERM. SAC.            42                         40                       43                       45


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

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