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TDMS Study 88120-04 Pathology Tables

NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99
Route: DOSED FEED                                                                                                 Time: 08:28:04

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  80-07-9

       Lock Date:  08/11/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            9            6            4                                     
    Moribund Sacrifice                                 3            1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           40           43           45                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (50)         (50)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Gallbladder                                        (49)         (49)         (50)         (49)                                   
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                                1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hepatocellular Carcinoma                         3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Hepatocellular Adenoma                           4 (8%)       4 (8%)       6 (12%)      7 (14%)                               
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)       2 (4%)                                
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Mesentery                                          (5)          (2)          (5)          (5)                                    
      Sarcoma NOS                                                                1 (20%)      1 (20%)                               
   Pancreas                                           (50)         (49)         (50)         (50)                                   
   Salivary Glands                                    (49)         (48)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Tongue                                                                                    (1)                                    
      Epithelium, Squamous Cell Carcinoma                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                                                                 1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (48)         (46)         (48)         (48)                                   
      Pars Distalis, Adenoma                           3 (6%)       2 (4%)       6 (13%)      6 (13%)                               
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (48)         (49)         (48)                                   
      Cystadenoma                                      2 (4%)       4 (8%)                    2 (4%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    2 (4%)                                
      Bilateral, Cystadenoma                                                     1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    2 (4%)                                
      Polyp Stromal                                    1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                                                     2 (4%)                                
   Lymph Node                                         (3)          (6)          (4)          (4)                                    
      Bronchial, Histiocytic Sarcoma                                1 (17%)                                                         
      Mediastinal, Carcinoma, Metastatic, Islets,                                                                                   
           Pancreatic                                  1 (33%)                                                                      
      Mediastinal, Histiocytic Sarcoma                              1 (17%)                                                         
      Renal, Histiocytic Sarcoma                                    1 (17%)                                                         
   Lymph Node, Mandibular                             (47)         (47)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (46)         (49)         (46)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (49)         (48)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Myxosarcoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma NOS                                                        3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Cranial Nerve, Schwannoma Malignant                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  4 (8%)       1 (2%)       2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                2 (4%)       1 (2%)       2 (4%)                                
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Cortex                               1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (3)          (1)                                    
   Harderian Gland                                    (3)          (2)          (2)          (2)                                    
      Adenoma                                          3 (100%)     2 (100%)     2 (100%)     1 (50%)                               
      Carcinoma                                                                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)       2 (4%)                                
      Lymphoma Malignant                               6 (12%)     10 (20%)      5 (10%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            23          28          20          26                                       
     Total Primary Neoplasms                           30          39          30          38                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          15          15          16                                       
     Total Benign Neoplasms                            17          18          20          23                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              12          18           9          14                                       
     Total Malignant Neoplasms                         13          21          10          15                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1                       1                                       
     Total Metastatic Neoplasm                          4           1                       1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9            3            4            5                                     
    Moribund Sacrifice                                 1            2            2            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           45           43           42                                     
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (49)         (50)                                   
      Polyp Adenomatous                                             1 (2%)                    2 (4%)                                
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)                                 1 (2%)                                
      Hepatocellular Carcinoma                         8 (16%)      2 (4%)       4 (8%)       4 (8%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)                    1 (2%)                                
      Hepatocellular Adenoma                           4 (8%)       8 (16%)      4 (8%)       9 (18%)                               
      Hepatocellular Adenoma, Multiple                 2 (4%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                                                       
   Oral Mucosa                                        (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                                                       
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
   Islets, Pancreatic                                 (50)         (49)         (49)         (49)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                       1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Mast Cell Tumor Malignant                        1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node                                         (2)          (1)          (1)          (1)                                    
   Lymph Node, Mandibular                             (46)         (49)         (48)         (50)                                   
   Lymph Node, Mesenteric                             (48)         (45)         (47)         (46)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                                                       
   Thymus                                             (45)         (47)         (39)         (44)                                   
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Mast Cell Tumor                                                                                          
          Malignant                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meninges, Meningioma Malignant                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       5 (10%)      3 (6%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   7 (14%)      5 (10%)      4 (8%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)                   1 (2%)       1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (2)          (2)          (1)                                    
      Adenoma                                          4 (80%)      1 (50%)      2 (100%)     1 (100%)                              
      Carcinoma                                                     1 (50%)                                                         
      Bilateral, Adenoma                               1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                       1 (2%)                                 1 (2%)                                
      Renal Tubule, Adenoma                                         1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lymphoma Malignant                               3 (6%)       3 (6%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  10                                                               
NTP Experiment-Test: 88120-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 09/24/99  
Route: DOSED FEED                                                                                                 Time: 08:28:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        30 PPM       100 PPM      300 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            32          28          22          21                                       
     Total Primary Neoplasms                           43          37          29          27                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          18          11          12                                       
     Total Benign Neoplasms                            19          21          13          14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          16          12          11                                       
     Total Malignant Neoplasms                         24          16          16          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           2           1           2                                       
     Total Metastatic Neoplasm                         15           2           1           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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