TDMS Study 88120-04 Pathology Tables
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 80-07-9
Lock Date: 08/11/98
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 5 9 6 4
Moribund Sacrifice 3 1 1 1
Survivors
Terminal Sacrifice 42 40 43 45
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49) (50) (50)
Squamous Cell Papilloma 1 (2%)
Gallbladder (49) (49) (50) (49)
Intestine Small, Jejunum (50) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Liver (50) (50) (50) (50)
Hemangioma 1 (2%)
Hepatocellular Carcinoma 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Hepatocellular Adenoma 4 (8%) 4 (8%) 6 (12%) 7 (14%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%)
Sarcoma, Metastatic, Skin 1 (2%)
Mesentery (5) (2) (5) (5)
Sarcoma NOS 1 (20%) 1 (20%)
Pancreas (50) (49) (50) (50)
Salivary Glands (49) (48) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Tongue (1)
Epithelium, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (50)
Histiocytic Sarcoma 1 (2%)
Adrenal Medulla (50) (49) (50) (50)
Pheochromocytoma Malignant 1 (2%)
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Carcinoma 1 (2%)
Pituitary Gland (48) (46) (48) (48)
Pars Distalis, Adenoma 3 (6%) 2 (4%) 6 (13%) 6 (13%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Follicular Cell, Adenoma 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (48) (49) (48)
Cystadenoma 2 (4%) 4 (8%) 2 (4%)
Granulosa Cell Tumor Benign 1 (2%)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Bilateral, Cystadenoma 1 (2%)
Uterus (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Polyp Stromal 1 (2%) 1 (2%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 2 (4%)
Lymph Node (3) (6) (4) (4)
Bronchial, Histiocytic Sarcoma 1 (17%)
Mediastinal, Carcinoma, Metastatic, Islets,
Pancreatic 1 (33%)
Mediastinal, Histiocytic Sarcoma 1 (17%)
Renal, Histiocytic Sarcoma 1 (17%)
Lymph Node, Mandibular (47) (47) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (46) (49) (46)
Histiocytic Sarcoma 1 (2%)
Spleen (49) (49) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Thymus (49) (48) (50) (50)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Carcinoma 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Myxosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma NOS 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Histiocytic Sarcoma 1 (2%)
Cranial Nerve, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 1 (2%) 2 (4%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Cortex 1 (2%)
Nose (50) (50) (50) (50)
Trachea (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (3) (1)
Harderian Gland (3) (2) (2) (2)
Adenoma 3 (100%) 2 (100%) 2 (100%) 1 (50%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%)
Lymphoma Malignant 6 (12%) 10 (20%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 23 28 20 26
Total Primary Neoplasms 30 39 30 38
Total Animals with Benign Neoplasms 15 15 15 16
Total Benign Neoplasms 17 18 20 23
Total Animals with Malignant Neoplasms 12 18 9 14
Total Malignant Neoplasms 13 21 10 15
Total Animals with Metastatic Neoplasms 3 1 1
Total Metastatic Neoplasm 4 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 9 3 4 5
Moribund Sacrifice 1 2 2 3
Survivors
Terminal Sacrifice 40 45 43 42
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
Intestine Large, Cecum (50) (50) (50) (50)
Carcinoma 1 (2%)
Intestine Small, Duodenum (50) (50) (49) (50)
Polyp Adenomatous 1 (2%) 2 (4%)
Intestine Small, Jejunum (50) (50) (50) (50)
Carcinoma 1 (2%)
Liver (50) (50) (50) (50)
Hemangiosarcoma 2 (4%) 1 (2%)
Hepatocellular Carcinoma 8 (16%) 2 (4%) 4 (8%) 4 (8%)
Hepatocellular Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 4 (8%) 8 (16%) 4 (8%) 9 (18%)
Hepatocellular Adenoma, Multiple 2 (4%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
Oral Mucosa (50) (50) (50) (50)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Islets, Pancreatic (50) (49) (49) (49)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
Thyroid Gland (50) (50) (50) (49)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Prostate (50) (50) (50) (50)
Testes (50) (50) (50) (50)
Interstitial Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Mast Cell Tumor Malignant 1 (2%) 1 (2%) 1 (2%)
Lymph Node (2) (1) (1) (1)
Lymph Node, Mandibular (46) (49) (48) (50)
Lymph Node, Mesenteric (48) (45) (47) (46)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
Spleen (50) (50) (50) (49)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
Thymus (45) (47) (39) (44)
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Mast Cell Tumor
Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Meninges, Meningioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 5 (10%) 3 (6%)
Alveolar/Bronchiolar Adenoma, Multiple 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 7 (14%) 5 (10%) 4 (8%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 1 (2%) 1 (2%)
Nose (50) (50) (50) (50)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (5) (2) (2) (1)
Adenoma 4 (80%) 1 (50%) 2 (100%) 1 (100%)
Carcinoma 1 (50%)
Bilateral, Adenoma 1 (20%)
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mast Cell Tumor Malignant, Metastatic, Bone
Marrow 1 (2%) 1 (2%)
Renal Tubule, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant 3 (6%) 3 (6%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 88120-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 09/24/99
Route: DOSED FEED Time: 08:28:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 30 PPM 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 32 28 22 21
Total Primary Neoplasms 43 37 29 27
Total Animals with Benign Neoplasms 16 18 11 12
Total Benign Neoplasms 19 21 13 14
Total Animals with Malignant Neoplasms 21 16 12 11
Total Malignant Neoplasms 24 16 16 13
Total Animals with Metastatic Neoplasms 7 2 1 2
Total Metastatic Neoplasm 15 2 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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