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TDMS Study 88120-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 09/24/99       
EXPERIMENT: 88120 TEST: 04                                                                                     TIME: 08:28:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B       
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 80-07-9         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 09/24/99

EXPERIMENT: 88120 TEST: 04                                                                                     TIME: 08:28:23
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 80-07-9

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pituitary Gland
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 09/24/99     
EXPERIMENT: 88120 TEST: 04                                                                                     TIME: 08:28:23     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B     
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 80-07-9       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF           P,P'-DICHLORODIPHENYL SULFONE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Liver                                  Hepatocellular Carcinoma
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs                             Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin                                   Sarcoma NOS
===============================================================
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    2/50 (4%)    1/50 (2%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     10.8%        2.1%         4.3%         2.2%        |6.4%         4.3%         4.1%         2.0%         |
|TERMINAL (d)       |     5/40 (13%)   1/45 (2%)    2/44 (5%)    1/42 (2%)   |3/42 (7%)    2/40 (5%)    2/43 (5%)    1/45 (2%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.161N     P=0.079N     P=0.180N     P=0.092N    |P=0.238N     P=0.522N     P=0.489N     P=0.281N     |
|POLY 3             |     P=0.176N     P=0.094N     P=0.218N     P=0.109N    |P=0.253N     P=0.509N     P=0.485N     P=0.291N     |
|POLY 1.5           |     P=0.172N     P=0.098N     P=0.220N     P=0.108N    |P=0.260N     P=0.506N     P=0.491N     P=0.297N     |
|POLY 6             |     P=0.179N     P=0.089N     P=0.211N     P=0.105N    |P=0.244N     P=0.513N     P=0.479N     P=0.283N     |
|LOGISTIC REGRESSION|     P=0.161N     P=0.079N     P=0.180N     P=0.092N    |P=0.238N     P=0.522N     P=0.489N     P=0.281N     |
|COCH-ARM / FISHERS |     P=0.162N     P=0.102N     P=0.218N     P=0.102N    |P=0.269N     P=0.500N     P=0.500N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/50 (4%)    1/50 (2%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     10.8%        4.1%         4.3%         2.2%        |6.4%         4.3%         4.1%         4.1%         |
|TERMINAL (d)       |     5/40 (13%)   1/45 (2%)    2/44 (5%)    1/42 (2%)   |3/42 (7%)    2/40 (5%)    2/43 (5%)    2/45 (4%)    |
|FIRST INCIDENCE    |     733 (T)      652          733 (T)      733 (T)     |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.126N     P=0.177N     P=0.180N     P=0.092N    |P=0.447N     P=0.522N     P=0.489N     P=0.469N     |
|POLY 3             |     P=0.138N     P=0.201N     P=0.218N     P=0.109N    |P=0.470N     P=0.509N     P=0.485N     P=0.481N     |
|POLY 1.5           |     P=0.134N     P=0.208N     P=0.220N     P=0.108N    |P=0.479N     P=0.506N     P=0.491N     P=0.489N     |
|POLY 6             |     P=0.140N     P=0.191N     P=0.211N     P=0.105N    |P=0.459N     P=0.513N     P=0.479N     P=0.472N     |
|LOGISTIC REGRESSION|     P=0.133N     P=0.209N     P=0.180N     P=0.092N    |P=0.447N     P=0.522N     P=0.489N     P=0.469N     |
|COCH-ARM / FISHERS |     P=0.125N     P=0.218N     P=0.218N     P=0.102N    |P=0.491N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Duodenum                                                                                                        |
|     Polyp Adenomatous                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    2/42 (5%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          712          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.149      P=0.527      (e)          P=0.249     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.145      P=0.507      (e)          P=0.231     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.146      P=0.504      (e)          P=0.231     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.147      P=0.512      (e)          P=0.233     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.142      P=0.501      (e)          P=0.249     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.151      P=0.500      (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Polyp Adenomatous                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    2/42 (5%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          712          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.149      P=0.527      (e)          P=0.249     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.145      P=0.507      (e)          P=0.231     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.146      P=0.504      (e)          P=0.231     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.147      P=0.512      (e)          P=0.233     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.142      P=0.501      (e)          P=0.249     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.151      P=0.500      (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.3%         0.0%         0.0%         2.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    0/45 (0%)    0/44 (0%)    1/42 (2%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     603          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.657N     P=0.227N     P=0.234N     P=0.496N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.658N     P=0.232N     P=0.240N     P=0.514N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.655N     P=0.234N     P=0.240N     P=0.511N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.661N     P=0.228N     P=0.238N     P=0.512N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.646N     P=0.242N     P=0.234N     P=0.497N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.650N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   9/50 (18%)   5/50 (10%)   9/50 (18%)  |4/50 (8%)    4/50 (8%)    6/50 (12%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     12.9%        18.5%        10.8%        19.6%       |8.5%         8.7%         12.3%        16.3%        |
|TERMINAL (d)       |     6/40 (15%)   8/45 (18%)   5/44 (11%)   8/42 (19%)  |4/42 (10%)   4/40 (10%)   5/43 (12%)   8/45 (18%)   |
|FIRST INCIDENCE    |     733 (T)      565          733 (T)      369         |734 (T)      734 (T)      702          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.326      P=0.372      P=0.433N     P=0.321     |P=0.142      P=0.617      P=0.388      P=0.212      |
|POLY 3             |     P=0.312      P=0.320      P=0.503N     P=0.279     |P=0.123      P=0.632      P=0.392      P=0.198      |
|POLY 1.5           |     P=0.316      P=0.306      P=0.506N     P=0.278     |P=0.115      P=0.636      P=0.383      P=0.190      |
|POLY 6             |     P=0.315      P=0.341      P=0.491N     P=0.290     |P=0.134      P=0.627      P=0.403      P=0.209      |
|LOGISTIC REGRESSION|     P=0.314      P=0.300      P=0.433N     P=0.278     |P=0.146      P=0.617      P=0.403      P=0.212      |
|COCH-ARM / FISHERS |     P=0.332      P=0.288      P=0.500N     P=0.288     |P=0.103      P=0.643N     P=0.370      P=0.178      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   3/50 (6%)    4/50 (8%)    5/50 (10%)  |3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     19.0%        6.2%         8.5%         10.9%       |6.3%         2.2%         4.1%         2.0%         |
|TERMINAL (d)       |     5/40 (13%)   3/45 (7%)    3/44 (7%)    3/42 (7%)   |1/42 (2%)    0/40 (0%)    2/43 (5%)    1/45 (2%)    |
|FIRST INCIDENCE    |     631          733 (T)      513          407         |631          690          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.384N     P=0.048N*    P=0.105N     P=0.191N    |P=0.312N     P=0.327N     P=0.486N     P=0.287N     |
|POLY 3             |     P=0.394N     P=0.057N     P=0.120N     P=0.210N    |P=0.327N     P=0.315N     P=0.490N     P=0.295N     |
|POLY 1.5           |     P=0.388N     P=0.058N     P=0.120N     P=0.207N    |P=0.334N     P=0.311N     P=0.494N     P=0.299N     |
|POLY 6             |     P=0.396N     P=0.056N     P=0.117N     P=0.209N    |P=0.319N     P=0.320N     P=0.487N     P=0.290N     |
|LOGISTIC REGRESSION|     P=0.361N     P=0.061N     P=0.116N     P=0.188N    |P=0.380N     P=0.284N     P=0.548N     P=0.366N     |
|COCH-ARM / FISHERS |     P=0.371N     P=0.061N     P=0.117N     P=0.194N    |P=0.343N     P=0.309N     P=0.500N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  11/50 (22%)  9/50 (18%)   13/50 (26%) |6/50 (12%)   5/50 (10%)   6/50 (12%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     31.6%        22.7%        19.2%        27.7%       |12.6%        10.8%        12.3%        16.3%        |
|TERMINAL (d)       |     11/40 (28%)  10/45 (22%)  8/44 (18%)   10/42 (24%) |4/42 (10%)   4/40 (10%)   5/43 (12%)   8/45 (18%)   |
|FIRST INCIDENCE    |     631          565          513          369         |631          690          702          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.551N     P=0.169N     P=0.092N     P=0.376N    |P=0.325      P=0.534N     P=0.597N     P=0.440      |
|POLY 3             |     P=0.547      P=0.225N     P=0.124N     P=0.425N    |P=0.285      P=0.519N     P=0.603N     P=0.411      |
|POLY 1.5           |     P=0.554      P=0.234N     P=0.125N     P=0.424N    |P=0.273      P=0.511N     P=0.609N     P=0.402      |
|POLY 6             |     P=0.546      P=0.214N     P=0.120N     P=0.419N    |P=0.299      P=0.528N     P=0.596N     P=0.422      |
|LOGISTIC REGRESSION|     P=0.545N     P=0.240N     P=0.123N     P=0.413N    |P=0.283      P=0.507N     P=0.615      P=0.397      |
|COCH-ARM / FISHERS |     P=0.539N     P=0.247N     P=0.121N     P=0.412N    |P=0.254      P=0.500N     P=0.620N     P=0.387      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  11/50 (22%)  9/50 (18%)   13/50 (26%) |6/50 (12%)   5/50 (10%)   6/50 (12%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     31.6%        22.7%        19.2%        27.7%       |12.6%        10.8%        12.3%        16.3%        |
|TERMINAL (d)       |     11/40 (28%)  10/45 (22%)  8/44 (18%)   10/42 (24%) |4/42 (10%)   4/40 (10%)   5/43 (12%)   8/45 (18%)   |
|FIRST INCIDENCE    |     631          565          513          369         |631          690          702          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.551N     P=0.169N     P=0.092N     P=0.376N    |P=0.325      P=0.534N     P=0.597N     P=0.440      |
|POLY 3             |     P=0.547      P=0.225N     P=0.124N     P=0.425N    |P=0.285      P=0.519N     P=0.603N     P=0.411      |
|POLY 1.5           |     P=0.554      P=0.234N     P=0.125N     P=0.424N    |P=0.273      P=0.511N     P=0.609N     P=0.402      |
|POLY 6             |     P=0.546      P=0.214N     P=0.120N     P=0.419N    |P=0.299      P=0.528N     P=0.596N     P=0.422      |
|LOGISTIC REGRESSION|     P=0.545N     P=0.240N     P=0.123N     P=0.413N    |P=0.283      P=0.507N     P=0.615      P=0.397      |
|COCH-ARM / FISHERS |     P=0.539N     P=0.247N     P=0.121N     P=0.412N    |P=0.254      P=0.500N     P=0.620N     P=0.387      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   4/50 (8%)    2/50 (4%)   |0/50 (0%)    4/50 (8%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     12.8%        12.4%        8.6%         4.4%        |0.0%         8.5%         4.1%         4.1%         |
|TERMINAL (d)       |     5/40 (13%)   5/45 (11%)   4/44 (9%)    1/42 (2%)   |0/42 (0%)    2/40 (5%)    2/43 (5%)    2/45 (4%)    |
|FIRST INCIDENCE    |     631          565          733 (T)      609         |---          592          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.087N     P=0.547N     P=0.319N     P=0.131N    |P=0.587      P=0.062      P=0.244      P=0.254      |
|POLY 3             |     P=0.095N     P=0.595N     P=0.377N     P=0.142N    |P=0.571      P=0.060      P=0.245      P=0.247      |
|POLY 1.5           |     P=0.092N     P=0.606N     P=0.378N     P=0.142N    |P=0.562      P=0.060      P=0.242      P=0.243      |
|POLY 6             |     P=0.094N     P=0.579N     P=0.370N     P=0.138N    |P=0.583      P=0.060      P=0.248      P=0.252      |
|LOGISTIC REGRESSION|     P=0.086N     P=0.620N     P=0.371N     P=0.137N    |P=0.511      P=0.069      P=0.244      P=0.254      |
|COCH-ARM / FISHERS |     P=0.083N     P=0.620N     P=0.370N     P=0.134N    |P=0.549      P=0.059      P=0.247      P=0.247      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   4/50 (8%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     15.0%        12.5%        8.6%         4.4%        |0.0%         4.3%         2.1%         4.1%         |
|TERMINAL (d)       |     6/40 (15%)   5/45 (11%)   4/44 (9%)    1/42 (2%)   |0/42 (0%)    2/40 (5%)    1/43 (2%)    2/45 (4%)    |
|FIRST INCIDENCE    |     661          718          733 (T)      712         |---          734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.060N     P=0.416N     P=0.216N     P=0.075N    |P=0.350      P=0.228      P=0.505      P=0.254      |
|POLY 3             |     P=0.067N     P=0.478N     P=0.267N     P=0.087N    |P=0.334      P=0.233      P=0.506      P=0.247      |
|POLY 1.5           |     P=0.065N     P=0.488N     P=0.268N     P=0.086N    |P=0.328      P=0.235      P=0.504      P=0.243      |
|POLY 6             |     P=0.067N     P=0.464N     P=0.260N     P=0.084N    |P=0.343      P=0.231      P=0.509      P=0.252      |
|LOGISTIC REGRESSION|     P=0.065N     P=0.473N     P=0.258N     P=0.087N    |(e)          P=0.228      P=0.505      P=0.254      |
|COCH-ARM / FISHERS |     P=0.058N     P=0.500N     P=0.262N     P=0.080N    |P=0.318      P=0.247      P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  8/50 (16%)   4/50 (8%)   |0/50 (0%)    6/50 (12%)   3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     27.6%        22.6%        17.3%        8.8%        |0.0%         12.8%        6.2%         6.1%         |
|TERMINAL (d)       |     11/40 (28%)  9/45 (20%)   8/44 (18%)   2/42 (5%)   |0/42 (0%)    4/40 (10%)   3/43 (7%)    3/45 (7%)    |
|FIRST INCIDENCE    |     631          565          733 (T)      609         |---          592          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.014N*    P=0.303N     P=0.117N     P=0.017N*   |P=0.559      P=0.017 *    P=0.125      P=0.134      |
|POLY 3             |     P=0.015N*    P=0.373N     P=0.172N     P=0.017N*   |P=0.537      P=0.015 *    P=0.125      P=0.127      |
|POLY 1.5           |     P=0.014N*    P=0.388N     P=0.171N     P=0.017N*   |P=0.526      P=0.015 *    P=0.123      P=0.123      |
|POLY 6             |     P=0.014N*    P=0.353N     P=0.167N     P=0.016N*   |P=0.552      P=0.015 *    P=0.128      P=0.131      |
|LOGISTIC REGRESSION|     P=0.014N*    P=0.396N     P=0.163N     P=0.018N*   |P=0.499      P=0.019 *    P=0.125      P=0.134      |
|COCH-ARM / FISHERS |     P=0.012N*    P=0.408N     P=0.163N     P=0.016N*   |P=0.510      P=0.013 *    P=0.121      P=0.121      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    4/48 (8%)    1/49 (2%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.2%         9.0%         2.1%         4.2%         |
|TERMINAL (d)       |                                                        |2/42 (5%)    3/39 (8%)    1/42 (2%)    2/44 (5%)    |
|FIRST INCIDENCE    |                                                        |734 (T)      694          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.408N     P=0.307      P=0.500N     P=0.678N     |
|POLY 3             |                                                        |P=0.440N     P=0.312      P=0.496N     P=0.693N     |
|POLY 1.5           |                                                        |P=0.447N     P=0.314      P=0.500N     P=0.688      |
|POLY 6             |                                                        |P=0.431N     P=0.311      P=0.491N     P=0.684N     |
|LOGISTIC REGRESSION|                                                        |P=0.420N     P=0.308      P=0.500N     P=0.678N     |
|COCH-ARM / FISHERS |                                                        |P=0.457N     P=0.319      P=0.508N     P=0.676      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |3/48 (6%)    2/46 (4%)    6/48 (13%)   6/48 (13%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.5%         4.6%         12.7%        12.6%        |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/43 (0%)    0/42 (0%)   |2/41 (5%)    1/38 (3%)    6/43 (14%)   6/44 (14%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |657          550          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.166      P=0.524N     P=0.269      P=0.281      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.150      P=0.526N     P=0.258      P=0.261      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.142      P=0.523N     P=0.252      P=0.253      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.528N     P=0.265      P=0.270      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.105      P=0.475N     P=0.241      P=0.236      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.130      P=0.520N     P=0.243      P=0.243      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma NOS                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         6.1%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          701          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.012 *    (e)          (e)          P=0.137      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.009 **   (e)          (e)          P=0.127      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.008 **   (e)          (e)          P=0.124      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.009 **   (e)          (e)          P=0.132      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.009 **   (e)          (e)          P=0.118      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.009 **   (e)          (e)          P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/49 (0%)   |2/50 (4%)    1/49 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         2.2%         0.0%        |4.2%         2.2%         0.0%         2.0%         |
|TERMINAL (d)       |     1/40 (3%)    0/45 (0%)    1/44 (2%)    0/42 (0%)   |2/42 (5%)    1/40 (3%)    0/43 (0%)    1/45 (2%)    |
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      ---         |734 (T)      734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.464N     P=0.477N     P=0.740N     P=0.490N    |P=0.471N     P=0.517N     P=0.233N     P=0.476N     |
|POLY 3             |     P=0.477N     P=0.493N     P=0.760      P=0.507N    |P=0.489N     P=0.514N     P=0.230N     P=0.486N     |
|POLY 1.5           |     P=0.475N     P=0.496N     P=0.759      P=0.507N    |P=0.493N     P=0.511N     P=0.233N     P=0.492N     |
|POLY 6             |     P=0.479N     P=0.489N     P=0.758N     P=0.504N    |P=0.486N     P=0.516N     P=0.227N     P=0.478N     |
|LOGISTIC REGRESSION|     P=0.464N     (e)          P=0.740N     (e)         |P=0.471N     P=0.517N     (e)          P=0.476N     |
|COCH-ARM / FISHERS |     P=0.468N     P=0.500N     P=0.753N     P=0.505N    |P=0.497N     P=0.508N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.4%         2.1%         2.2%         2.2%        |0.0%         4.3%         0.0%         0.0%         |
|TERMINAL (d)       |     2/40 (5%)    1/45 (2%)    1/44 (2%)    1/42 (2%)   |0/42 (0%)    2/40 (5%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     603          733 (T)      733 (T)      733 (T)     |---          734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.346N     P=0.276N     P=0.286N     P=0.300N    |P=0.352N     P=0.228      (e)          (e)          |
|POLY 3             |     P=0.358N     P=0.297N     P=0.310N     P=0.320N    |P=0.367N     P=0.233      (e)          (e)          |
|POLY 1.5           |     P=0.354N     P=0.301N     P=0.310N     P=0.317N    |P=0.368N     P=0.235      (e)          (e)          |
|POLY 6             |     P=0.360N     P=0.291N     P=0.306N     P=0.317N    |P=0.367N     P=0.231      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.347N     P=0.307N     P=0.305N     P=0.306N    |(e)          P=0.228      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.342N     P=0.309N     P=0.309N     P=0.309N    |P=0.369N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.4%         4.2%         2.2%         2.2%        |0.0%         4.3%         2.1%         0.0%         |
|TERMINAL (d)       |     2/40 (5%)    2/45 (4%)    1/44 (2%)    1/42 (2%)   |0/42 (0%)    2/40 (5%)    1/43 (2%)    0/45 (0%)    |
|FIRST INCIDENCE    |     603          733 (T)      733 (T)      733 (T)     |---          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.267N     P=0.457N     P=0.286N     P=0.300N    |P=0.356N     P=0.228      P=0.505      (e)          |
|POLY 3             |     P=0.278N     P=0.489N     P=0.310N     P=0.320N    |P=0.368N     P=0.233      P=0.506      (e)          |
|POLY 1.5           |     P=0.275N     P=0.494N     P=0.310N     P=0.317N    |P=0.372N     P=0.235      P=0.504      (e)          |
|POLY 6             |     P=0.279N     P=0.482N     P=0.306N     P=0.317N    |P=0.363N     P=0.231      P=0.509      (e)          |
|LOGISTIC REGRESSION|     P=0.269N     P=0.501N     P=0.305N     P=0.306N    |(e)          P=0.228      P=0.505      (e)          |
|COCH-ARM / FISHERS |     P=0.263N     P=0.500N     P=0.309N     P=0.309N    |P=0.378N     P=0.247      P=0.500      (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.1%         0.0%        |0.0%         4.2%         2.1%         4.1%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    1/45 (2%)    |
|FIRST INCIDENCE    |     ---          ---          649          ---         |---          512          732          723          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.796N     (e)          P=0.500      (e)         |P=0.342      P=0.243      P=0.509      P=0.260      |
|POLY 3             |     P=0.793N     (e)          P=0.500      (e)         |P=0.334      P=0.239      P=0.507      P=0.247      |
|POLY 1.5           |     P=0.791N     (e)          P=0.499      (e)         |P=0.327      P=0.238      P=0.504      P=0.243      |
|POLY 6             |     P=0.792N     (e)          P=0.505      (e)         |P=0.342      P=0.240      P=0.509      P=0.252      |
|LOGISTIC REGRESSION|     P=0.777N     (e)          P=0.505      (e)         |P=0.100      P=0.244      P=0.511      P=0.247      |
|COCH-ARM / FISHERS |     P=0.786N     (e)          P=0.500      (e)         |P=0.318      P=0.247      P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |6/50 (12%)   10/50 (20%)  5/50 (10%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     6.3%         6.2%         4.3%         2.2%        |12.4%        21.6%        10.1%        6.1%         |
|TERMINAL (d)       |     1/40 (3%)    3/45 (7%)    1/44 (2%)    1/42 (2%)   |3/42 (7%)    9/40 (23%)   3/43 (7%)    3/45 (7%)    |
|FIRST INCIDENCE    |     550          733 (T)      705          733 (T)     |491          694          586          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.217N     P=0.621N     P=0.480N     P=0.311N    |P=0.058N     P=0.187      P=0.478N     P=0.219N     |
|POLY 3             |     P=0.228N     P=0.656N     P=0.509N     P=0.323N    |P=0.065N     P=0.181      P=0.485N     P=0.234N     |
|POLY 1.5           |     P=0.223N     P=0.658N     P=0.508N     P=0.319N    |P=0.068N     P=0.191      P=0.491N     P=0.238N     |
|POLY 6             |     P=0.229N     P=0.650N     P=0.506N     P=0.322N    |P=0.062N     P=0.171      P=0.477N     P=0.229N     |
|LOGISTIC REGRESSION|     P=0.208N     P=0.657      P=0.494N     P=0.293N    |P=0.096N     P=0.212      P=0.580      P=0.358N     |
|COCH-ARM / FISHERS |     P=0.209N     P=0.661N     P=0.500N     P=0.309N    |P=0.073N     P=0.207      P=0.500N     P=0.243N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/50 (32%)  18/50 (36%)  11/50 (22%)  12/50 (24%) |15/50 (30%)  15/50 (30%)  15/50 (30%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     34.2%        37.0%        23.8%        25.9%       |31.4%        31.5%        30.5%        32.6%        |
|TERMINAL (d)       |     15/40 (38%)  15/45 (33%)  11/44 (25%)  10/42 (24%) |13/42 (31%)  11/40 (28%)  13/43 (30%)  16/45 (36%)  |
|FIRST INCIDENCE    |     631          565          733 (T)      369         |636          550          652          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.153N     P=0.574      P=0.116N     P=0.217N    |P=0.518N     P=0.527      P=0.547N     P=0.579N     |
|POLY 3             |     P=0.162N     P=0.472      P=0.190N     P=0.259N    |P=0.495      P=0.581      P=0.551N     P=0.537      |
|POLY 1.5           |     P=0.159N     P=0.448      P=0.192N     P=0.262N    |P=0.478      P=0.583      P=0.565N     P=0.522      |
|POLY 6             |     P=0.157N     P=0.508      P=0.179N     P=0.242N    |P=0.513      P=0.581      P=0.535N     P=0.553      |
|LOGISTIC REGRESSION|     P=0.168N     P=0.447      P=0.164N     P=0.268N    |P=0.474      P=0.584      P=0.564N     P=0.564      |
|COCH-ARM / FISHERS |     P=0.146N     P=0.417      P=0.184N     P=0.252N    |P=0.452      P=0.586N     P=0.586N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     21/50 (42%)  16/50 (32%)  12/50 (24%)  11/50 (22%) |12/50 (24%)  18/50 (36%)  9/50 (18%)   11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     43.1%        33.0%        24.9%        23.8%       |24.3%        37.3%        18.2%        22.2%        |
|TERMINAL (d)       |     14/40 (35%)  13/45 (29%)  8/44 (18%)   8/42 (19%)  |6/42 (14%)   13/40 (33%)  6/43 (14%)   8/45 (18%)   |
|FIRST INCIDENCE    |     550          652          413          407         |491          512          586          690          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.051N     P=0.135N     P=0.042N*    P=0.032N*   |P=0.174N     P=0.134      P=0.298N     P=0.433N     |
|POLY 3             |     P=0.049N*    P=0.209N     P=0.046N*    P=0.037N*   |P=0.219N     P=0.120      P=0.314N     P=0.499N     |
|POLY 1.5           |     P=0.044N*    P=0.207N     P=0.045N*    P=0.033N*   |P=0.223N     P=0.128      P=0.313N     P=0.499N     |
|POLY 6             |     P=0.053N     P=0.210N     P=0.045N*    P=0.040N*   |P=0.214N     P=0.111      P=0.318N     P=0.498N     |
|LOGISTIC REGRESSION|     P=0.036N*    P=0.200N     P=0.043N*    P=0.027N*   |P=0.411N     P=0.170      P=0.510N     P=0.476      |
|COCH-ARM / FISHERS |     P=0.035N*    P=0.204N     P=0.044N*    P=0.026N*   |P=0.227N     P=0.138      P=0.312N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/50 (64%)  28/50 (56%)  22/50 (44%)  21/50 (42%) |23/50 (46%)  28/50 (56%)  20/50 (40%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     65.6%        57.1%        45.7%        44.3%       |46.6%        57.3%        40.3%        46.5%        |
|TERMINAL (d)       |     25/40 (63%)  24/45 (53%)  18/44 (41%)  16/42 (38%) |17/42 (41%)  22/40 (55%)  16/43 (37%)  20/45 (44%)  |
|FIRST INCIDENCE    |     550          565          413          369         |491          512          586          690          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.043N*    P=0.136N     P=0.026N*    P=0.028N*   |P=0.242N     P=0.186      P=0.317N     P=0.459N     |
|POLY 3             |     P=0.032N*    P=0.257N     P=0.036N*    P=0.027N*   |P=0.364N     P=0.194      P=0.337N     P=0.577N     |
|POLY 1.5           |     P=0.028N*    P=0.262N     P=0.035N*    P=0.024N*   |P=0.369N     P=0.203      P=0.339N     P=0.578N     |
|POLY 6             |     P=0.033N*    P=0.249N     P=0.035N*    P=0.027N*   |P=0.357N     P=0.182      P=0.336N     P=0.576N     |
|LOGISTIC REGRESSION|     P=0.027N*    P=0.254N     P=0.036N*    P=0.024N*   |P=0.497N     P=0.241      P=0.449N     P=0.490      |
|COCH-ARM / FISHERS |     P=0.024N*    P=0.270N     P=0.035N*    P=0.022N*   |P=0.374N     P=0.212      P=0.343N     P=0.579N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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