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TDMS Study 88120-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 09/24/99       
EXPERIMENT: 88120 TEST: 04                                                                                     TIME: 08:34:25       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B       
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 80-07-9         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 09/24/99     
EXPERIMENT: 88120 TEST: 04                                                                                     TIME: 08:34:25     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B     
PATHOLOGIST: RYAN, MICHAEL                                                                                     CAS: 80-07-9       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF           P,P'-DICHLORODIPHENYL SULFONE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Heart: Artery                          Inflammation Chronic
Kidney                                 Nephropathy
Kidney: Renal Tubule                   Necrosis Acute
Liver                                  Basophilic Focus
                                       Fatty Change Diffuse
                                       Inflammation Focal
Liver: Centrilobular                   Hypertrophy
Preputial Gland                        Cyst
                                       Inflammation
                                       Inflammation Chronic
Spleen                                 Hematopoietic Cell Proliferation
Spleen: Lymphoid Follicle              Atrophy
                                       Hyperplasia
Thymus                                 Atrophy
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Bone                                   Fibrosis
Liver                                  Eosinophilic Focus
Liver: Centrilobular                   Hypertrophy
Lung                                   Inflammation Chronic Focal
Ovary                                  Hemorrhage
Spleen                                 Hematopoietic Cell Proliferation
Stomach, Glandular: Epithelium         Cyst
Thymus                                 Hyperplasia Lymphoid
Uterus                                 Inflammation
                                       Inflammation Granulomatous
Uterus: Endometrium                    Hyperplasia Cystic
===============================================================
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 1

Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Cytoplasmic Alteration Focal                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/49 (20%)  13/50 (26%)  11/50 (22%)  7/50 (14%)  |1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     21.9%        27.1%        23.8%        15.5%       |2.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     10/40 (25%)  13/45 (29%)  11/44 (25%)  7/42 (17%)  |1/42 (2%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.137N     P=0.437      P=0.599      P=0.257N    |P=0.461N     P=0.510N     P=0.495N     P=0.486N     |
|POLY 3             |     P=0.161N     P=0.368      P=0.515      P=0.305N    |P=0.473N     P=0.506N     P=0.494N     P=0.492N     |
|POLY 1.5           |     P=0.155N     P=0.355      P=0.512      P=0.302N    |P=0.473N     P=0.505N     P=0.496N     P=0.495N     |
|POLY 6             |     P=0.159N     P=0.388      P=0.530      P=0.297N    |P=0.474N     P=0.507N     P=0.491N     P=0.487N     |
|LOGISTIC REGRESSION|     P=0.137N     P=0.437      P=0.599      P=0.257N    |P=0.461N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.134N     P=0.337      P=0.521      P=0.282N    |P=0.473N     P=0.505N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    4/50 (8%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    1/49 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.6%         8.3%         2.2%         6.7%        |2.1%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     3/40 (8%)    3/45 (7%)    1/44 (2%)    3/42 (7%)   |1/42 (2%)    1/40 (3%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     733 (T)      718          733 (T)      733 (T)     |734 (T)      734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.543N     P=0.563      P=0.272N     P=0.641N    |P=0.288N     P=0.751      P=0.495N     P=0.486N     |
|POLY 3             |     P=0.551N     P=0.528      P=0.300N     P=0.657     |P=0.300N     P=0.753      P=0.494N     P=0.492N     |
|POLY 1.5           |     P=0.547N     P=0.521      P=0.301N     P=0.659     |P=0.301N     P=0.754      P=0.496N     P=0.495N     |
|POLY 6             |     P=0.550N     P=0.540      P=0.295N     P=0.662     |P=0.298N     P=0.753      P=0.491N     P=0.487N     |
|LOGISTIC REGRESSION|     P=0.552N     P=0.550      P=0.272N     P=0.641N    |P=0.288N     P=0.751      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.533N     P=0.511      P=0.301N     P=0.651N    |P=0.301N     P=0.747      P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 2

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/49 (29%)  16/50 (32%)  21/50 (42%)  15/50 (30%) |2/50 (4%)    0/49 (0%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     30.7%        33.3%        45.4%        33.3%       |4.2%         0.0%         0.0%         6.1%         |
|TERMINAL (d)       |     14/40 (35%)  16/45 (36%)  21/44 (48%)  15/42 (36%) |2/42 (5%)    0/40 (0%)    0/43 (0%)    3/45 (7%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |734 (T)      ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.553N     P=0.569      P=0.170      P=0.565     |P=0.179      P=0.249N     P=0.233N     P=0.531      |
|POLY 3             |     P=0.499      P=0.479      P=0.106      P=0.485     |P=0.164      P=0.244N     P=0.230N     P=0.519      |
|POLY 1.5           |     P=0.517      P=0.462      P=0.106      P=0.491     |P=0.161      P=0.243N     P=0.233N     P=0.511      |
|POLY 6             |     P=0.501      P=0.506      P=0.115      P=0.498     |P=0.168      P=0.245N     P=0.227N     P=0.528      |
|LOGISTIC REGRESSION|     P=0.553N     P=0.569      P=0.170      P=0.565     |P=0.179      (e)          (e)          P=0.531      |
|COCH-ARM / FISHERS |     P=0.525N     P=0.440      P=0.117      P=0.526     |P=0.157      P=0.253N     P=0.247N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex: Subcapsular                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     40/49 (82%)  42/50 (84%)  41/50 (82%)  44/50 (88%) |47/50 (94%)  47/49 (96%)  50/50 (100%) 47/50 (94%)  |
|POLY-3 ADJUSTED (b)|     85.3%        85.7%        83.9%        94.4%       |95.9%        96.4%        100.0%       94.3%        |
|TERMINAL (d)       |     36/40 (90%)  38/45 (84%)  37/44 (84%)  40/42 (95%) |41/42 (98%)  40/40 (100%) 43/43 (100%) 44/45 (98%)  |
|FIRST INCIDENCE    |     550          565          406          379         |580          512          586          578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199      P=0.352N     P=0.366N     P=0.374     |P=0.111N     P=0.375      P=0.428      P=0.255N     |
|POLY 3             |     P=0.088      P=0.592      P=0.537N     P=0.115     |P=0.376N     P=0.661      P=0.204      P=0.545N     |
|POLY 1.5           |     P=0.118      P=0.542      P=0.579N     P=0.145     |P=0.427N     P=0.601      P=0.157      P=0.593N     |
|POLY 6             |     P=0.081      P=0.563N     P=0.468N     P=0.122     |P=0.324N     P=0.722      P=0.288      P=0.495N     |
|LOGISTIC REGRESSION|     P=0.117      P=0.551      P=0.551      P=0.092     |P=0.338N     P=0.459      P=0.252      P=0.465N     |
|COCH-ARM / FISHERS |     P=0.246      P=0.482      P=0.584      P=0.274     |P=0.504N     P=0.510      P=0.121      P=0.661N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 3

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |10/50 (20%)  4/50 (8%)    12/50 (24%)  15/50 (30%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         4.4%        |21.2%        8.7%         24.6%        30.5%        |
|TERMINAL (d)       |     0/40 (0%)    1/45 (2%)    0/44 (0%)    2/42 (5%)   |10/42 (24%)  4/40 (10%)   12/43 (28%)  15/45 (33%)  |
|FIRST INCIDENCE    |     ---          733 (T)      ---          733 (T)     |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.148      P=0.523      (e)          P=0.249     |P=0.043 *    P=0.087N     P=0.428      P=0.230      |
|POLY 3             |     P=0.145      P=0.507      (e)          P=0.231     |P=0.033 *    P=0.078N     P=0.438      P=0.209      |
|POLY 1.5           |     P=0.146      P=0.504      (e)          P=0.231     |P=0.029 *    P=0.076N     P=0.425      P=0.196      |
|POLY 6             |     P=0.147      P=0.511      (e)          P=0.233     |P=0.039 *    P=0.080N     P=0.454      P=0.227      |
|LOGISTIC REGRESSION|     (e)          P=0.523      (e)          P=0.249     |P=0.043 *    P=0.087N     P=0.428      P=0.230      |
|COCH-ARM / FISHERS |     P=0.151      P=0.500      (e)          P=0.247     |P=0.025 *    P=0.074N     P=0.405      P=0.178      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    3/50 (6%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         2.2%         6.1%         2.1%         |
|TERMINAL (d)       |                                                        |0/42 (0%)    1/40 (3%)    2/43 (5%)    1/45 (2%)    |
|FIRST INCIDENCE    |                                                        |---          734 (T)      702          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.544      P=0.490      P=0.130      P=0.514      |
|POLY 3             |                                                        |P=0.534      P=0.496      P=0.125      P=0.505      |
|POLY 1.5           |                                                        |P=0.521      P=0.498      P=0.123      P=0.501      |
|POLY 6             |                                                        |P=0.550      P=0.494      P=0.129      P=0.509      |
|LOGISTIC REGRESSION|                                                        |P=0.526      P=0.490      P=0.121      P=0.514      |
|COCH-ARM / FISHERS |                                                        |P=0.504      P=0.500      P=0.121      P=0.495      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 4

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.3%         0.0%         4.3%         4.4%        |                                                    |
|TERMINAL (d)       |     2/40 (5%)    0/45 (0%)    2/44 (5%)    2/42 (5%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      733 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.420      P=0.213N     P=0.660N     P=0.677N    |                                                    |
|POLY 3             |     P=0.399      P=0.230N     P=0.692      P=0.683     |                                                    |
|POLY 1.5           |     P=0.405      P=0.233N     P=0.691      P=0.684     |                                                    |
|POLY 6             |     P=0.398      P=0.225N     P=0.689N     P=0.687     |                                                    |
|LOGISTIC REGRESSION|     P=0.420      (e)          P=0.660N     P=0.677N    |                                                    |
|COCH-ARM / FISHERS |     P=0.423      P=0.247N     P=0.691N     P=0.691N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |0/1 (0%)     2/3 (67%)    1/3 (33%)    0/1 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         66.7%        33.3%        0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     2/3 (67%)    1/3 (33%)    0/1 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.388N     P=1.000      P=1.000      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.484N     P=0.535      P=0.707      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.493N     P=0.518      P=0.699      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.467N     P=0.567      P=0.720      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=1.000      P=1.000      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.504N     P=0.500      P=0.750      (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 5

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     1/1 (100%)   0/0 (0%)     0/0 (0%)    |0/1 (0%)     1/3 (33%)    2/3 (67%)    1/1 (100%)   |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       0.0%         0.0%        |0.0%         33.3%        66.7%        100.0%       |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     1/3 (33%)    2/3 (67%)    1/1 (100%)   |
|FIRST INCIDENCE    |     ---          652          ---          ---         |---          734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.388      P=1.000      P=1.000      P=1.000N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.299      P=0.707      P=0.535      P=1.000N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.289      P=0.699      P=0.518      P=1.000N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.317      P=0.720      P=0.567      P=1.000N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=1.000      P=1.000      P=1.000N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.249      P=0.750      P=0.500      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         2.2%         8.9%        |2.1%         0.0%         0.0%         4.1%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    1/44 (2%)    4/42 (10%)  |1/42 (2%)    0/40 (0%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     ---          565          733 (T)      733 (T)     |734 (T)      ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.018 *    P=0.504      P=0.519      P=0.070     |P=0.210      P=0.510N     P=0.495N     P=0.524      |
|POLY 3             |     P=0.016 *    P=0.509      P=0.499      P=0.057     |P=0.198      P=0.504N     P=0.494N     P=0.514      |
|POLY 1.5           |     P=0.017 *    P=0.505      P=0.498      P=0.057     |P=0.194      P=0.502N     P=0.496N     P=0.508      |
|POLY 6             |     P=0.016 *    P=0.514      P=0.503      P=0.058     |P=0.202      P=0.506N     P=0.491N     P=0.522      |
|LOGISTIC REGRESSION|     P=0.019 *    P=0.488      P=0.519      P=0.070     |P=0.210      (e)          (e)          P=0.524      |
|COCH-ARM / FISHERS |     P=0.019 *    P=0.500      P=0.500      P=0.059     |P=0.189      P=0.500N     P=0.500N     P=0.500      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 6

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Myocardium                                                                                                                |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.2%         2.1%         2.2%        |2.1%         0.0%         2.1%         4.1%         |
|TERMINAL (d)       |     0/40 (0%)    2/45 (4%)    0/44 (0%)    0/42 (0%)   |1/42 (2%)    0/40 (0%)    1/43 (2%)    1/45 (2%)    |
|FIRST INCIDENCE    |     ---          565          649          712         |734 (T)      ---          734 (T)      726          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.592N     P=0.139      P=0.500      P=0.510     |P=0.259      P=0.510N     P=0.756N     P=0.526      |
|POLY 3             |     P=0.588N     P=0.127      P=0.500      P=0.494     |P=0.248      P=0.504N     P=0.753N     P=0.515      |
|POLY 1.5           |     P=0.588N     P=0.124      P=0.499      P=0.495     |P=0.241      P=0.502N     P=0.756N     P=0.508      |
|POLY 6             |     P=0.582N     P=0.132      P=0.505      P=0.497     |P=0.256      P=0.506N     P=0.750N     P=0.522      |
|LOGISTIC REGRESSION|     P=0.570N     P=0.116      P=0.505      P=0.497     |P=0.258      (e)          P=0.756N     P=0.526      |
|COCH-ARM / FISHERS |     P=0.581N     P=0.121      P=0.500      P=0.500     |P=0.231      P=0.500N     P=0.753N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Myocardium                                                                                                                |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.3%         0.0%         0.0%         0.0%        |0.0%         2.1%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     550          ---          ---          ---         |---          512          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.142N     P=0.119N     P=0.126N     P=0.132N    |P=0.574N     P=0.504      (e)          (e)          |
|POLY 3             |     P=0.134N     P=0.117N     P=0.124N     P=0.128N    |P=0.576N     P=0.499      (e)          (e)          |
|POLY 1.5           |     P=0.133N     P=0.118N     P=0.123N     P=0.126N    |P=0.576N     P=0.499      (e)          (e)          |
|POLY 6             |     P=0.136N     P=0.115N     P=0.123N     P=0.128N    |P=0.576N     P=0.498      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.123N     P=0.125N     P=0.113N     P=0.108N    |P=0.996      P=0.553      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.134N     P=0.121N     P=0.121N     P=0.121N    |P=0.576N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 7

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Jejunum: Peyer's Patch                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.2%        |4.2%         0.0%         0.0%         8.1%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    1/42 (2%)   |2/42 (5%)    0/40 (0%)    0/43 (0%)    4/45 (9%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |734 (T)      ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.212      (e)          (e)          P=0.510     |P=0.067      P=0.249N     P=0.233N     P=0.369      |
|POLY 3             |     P=0.207      (e)          (e)          P=0.494     |P=0.056      P=0.242N     P=0.230N     P=0.357      |
|POLY 1.5           |     P=0.209      (e)          (e)          P=0.495     |P=0.054      P=0.240N     P=0.233N     P=0.349      |
|POLY 6             |     P=0.208      (e)          (e)          P=0.496     |P=0.059      P=0.244N     P=0.227N     P=0.367      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.510     |P=0.067      (e)          (e)          P=0.369      |
|COCH-ARM / FISHERS |     P=0.214      (e)          (e)          P=0.500     |P=0.053      P=0.247N     P=0.247N     P=0.339      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  13/49 (27%)  7/49 (14%)   9/49 (18%)  |4/50 (8%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     27.6%        26.8%        14.9%        19.4%       |8.5%         4.3%         6.1%         4.1%         |
|TERMINAL (d)       |     11/40 (28%)  12/45 (27%)  6/44 (14%)   7/42 (17%)  |4/42 (10%)   1/40 (3%)    2/43 (5%)    2/45 (4%)    |
|FIRST INCIDENCE    |     631          565          406          407         |734 (T)      512          586          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188N     P=0.464N     P=0.077N     P=0.216N    |P=0.336N     P=0.356N     P=0.486N     P=0.306N     |
|POLY 3             |     P=0.194N     P=0.554N     P=0.103N     P=0.243N    |P=0.353N     P=0.340N     P=0.477N     P=0.319N     |
|POLY 1.5           |     P=0.195N     P=0.570N     P=0.105N     P=0.249N    |P=0.361N     P=0.339N     P=0.486N     P=0.327N     |
|POLY 6             |     P=0.189N     P=0.533N     P=0.097N     P=0.231N    |P=0.342N     P=0.341N     P=0.466N     P=0.309N     |
|LOGISTIC REGRESSION|     P=0.173N     P=0.588      P=0.115N     P=0.250N    |P=0.461N     P=0.318N     P=0.535N     P=0.306N     |
|COCH-ARM / FISHERS |     P=0.185N     P=0.567      P=0.115N     P=0.251N    |P=0.373N     P=0.339N     P=0.500N     P=0.339N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 8

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         4.3%         2.2%        |6.4%         4.3%         4.1%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    2/44 (5%)    1/42 (2%)   |3/42 (7%)    2/40 (5%)    2/43 (5%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          652          733 (T)      733 (T)     |734 (T)      734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.495      P=0.513      P=0.260      P=0.510     |P=0.085N     P=0.522N     P=0.489N     P=0.109N     |
|POLY 3             |     P=0.480      P=0.508      P=0.236      P=0.494     |P=0.090N     P=0.509N     P=0.485N     P=0.112N     |
|POLY 1.5           |     P=0.484      P=0.504      P=0.235      P=0.495     |P=0.094N     P=0.506N     P=0.491N     P=0.115N     |
|POLY 6             |     P=0.482      P=0.513      P=0.240      P=0.496     |P=0.086N     P=0.513N     P=0.479N     P=0.108N     |
|LOGISTIC REGRESSION|     P=0.494      P=0.494      P=0.260      P=0.510     |P=0.085N     P=0.522N     P=0.489N     (e)          |
|COCH-ARM / FISHERS |     P=0.500      P=0.500      P=0.247      P=0.500     |P=0.098N     P=0.500N     P=0.500N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     36/50 (72%)  44/50 (88%)  42/50 (84%)  36/50 (72%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     77.2%        91.5%        87.4%        79.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     35/40 (88%)  43/45 (96%)  39/44 (89%)  36/42 (86%) |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     691          712          406          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.160N     P=0.215      P=0.347      P=0.410N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.350N     P=0.040 *    P=0.138      P=0.478     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.308N     P=0.035 *    P=0.118      P=0.497     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.339N     P=0.053      P=0.187      P=0.513     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.387N     P=0.174      P=0.070      P=0.466N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.201N     P=0.039 *    P=0.114      P=0.588N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 9

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Casts Protein                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |32/50 (64%)  30/50 (60%)  31/50 (62%)  38/50 (76%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |64.6%        61.4%        63.1%        76.3%        |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |25/42 (60%)  23/40 (58%)  28/43 (65%)  36/45 (80%)  |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |491          512          652          578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.225      P=0.525N     P=0.438N     P=0.306      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.068      P=0.453N     P=0.522N     P=0.143      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.065      P=0.437N     P=0.512N     P=0.141      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.072      P=0.475N     P=0.541N     P=0.144      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.050      P=0.390N     P=0.520N     P=0.106      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.061      P=0.418N     P=0.500N     P=0.138      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         6.2%         0.0%         2.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    3/45 (7%)    0/44 (0%)    1/42 (2%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.428N     P=0.348      P=0.481N     P=0.751N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.433N     P=0.317      P=0.501N     P=0.754     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.432N     P=0.312      P=0.502N     P=0.755     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.429N     P=0.325      P=0.497N     P=0.757     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.428N     P=0.348      (e)          P=0.751N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.427N     P=0.309      P=0.500N     P=0.753N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 10

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |2/42 (5%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.230N     P=0.249N     P=0.233N     P=0.223N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.237N     P=0.242N     P=0.230N     P=0.228N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.239N     P=0.240N     P=0.233N     P=0.232N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.235N     P=0.244N     P=0.227N     P=0.224N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.230N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.242N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Necrosis Acute                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         6.4%        |2.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          379         |580          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.008 **   (e)          (e)          P=0.118     |P=0.472N     P=0.508N     P=0.496N     P=0.500N     |
|POLY 3             |     P=0.008 **   (e)          (e)          P=0.122     |P=0.471N     P=0.506N     P=0.496N     P=0.494N     |
|POLY 1.5           |     P=0.008 **   (e)          (e)          P=0.120     |P=0.473N     P=0.504N     P=0.497N     P=0.496N     |
|POLY 6             |     P=0.008 **   (e)          (e)          P=0.126     |P=0.470N     P=0.509N     P=0.494N     P=0.491N     |
|LOGISTIC REGRESSION|     P=0.011 *    (e)          (e)          P=0.134     |P=0.731N     P=0.441N     P=0.789N     P=0.784N     |
|COCH-ARM / FISHERS |     P=0.009 **   (e)          (e)          P=0.121     |P=0.474N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 11

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.5%         8.2%         2.2%         0.0%        |0.0%         2.2%         0.0%         4.1%         |
|TERMINAL (d)       |     3/40 (8%)    3/45 (7%)    1/44 (2%)    0/42 (0%)   |0/42 (0%)    1/40 (3%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     733 (T)      565          733 (T)      ---         |---          734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.048N*    P=0.556      P=0.272N     P=0.113N    |P=0.170      P=0.490      (e)          P=0.254      |
|POLY 3             |     P=0.051N     P=0.524      P=0.307N     P=0.124N    |P=0.158      P=0.496      (e)          P=0.247      |
|POLY 1.5           |     P=0.050N     P=0.514      P=0.308N     P=0.124N    |P=0.155      P=0.498      (e)          P=0.243      |
|POLY 6             |     P=0.050N     P=0.539      P=0.301N     P=0.122N    |P=0.162      P=0.494      (e)          P=0.252      |
|LOGISTIC REGRESSION|     P=0.049N*    P=0.500      P=0.272N     (e)         |(e)          P=0.490      (e)          P=0.254      |
|COCH-ARM / FISHERS |     P=0.048N*    P=0.500      P=0.309N     P=0.121N    |P=0.151      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   3/50 (6%)    4/50 (8%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     10.8%        12.5%        6.4%         8.9%        |4.2%         2.2%         0.0%         2.0%         |
|TERMINAL (d)       |     5/40 (13%)   6/45 (13%)   2/44 (5%)    4/42 (10%)  |2/42 (5%)    1/40 (3%)    0/43 (0%)    1/45 (2%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      406          733 (T)     |734 (T)      734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.375N     P=0.582      P=0.313N     P=0.469N    |P=0.471N     P=0.517N     P=0.233N     P=0.476N     |
|POLY 3             |     P=0.397N     P=0.523      P=0.349N     P=0.519N    |P=0.492N     P=0.507N     P=0.230N     P=0.486N     |
|POLY 1.5           |     P=0.392N     P=0.513      P=0.355N     P=0.517N    |P=0.495N     P=0.504N     P=0.233N     P=0.492N     |
|POLY 6             |     P=0.395N     P=0.538      P=0.338N     P=0.511N    |P=0.488N     P=0.510N     P=0.227N     P=0.478N     |
|LOGISTIC REGRESSION|     P=0.385N     P=0.582      P=0.354N     P=0.469N    |P=0.471N     P=0.517N     (e)          P=0.476N     |
|COCH-ARM / FISHERS |     P=0.372N     P=0.500      P=0.357N     P=0.500N    |P=0.500N     P=0.500N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 12

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   9/50 (18%)   7/50 (14%)   8/50 (16%)  |2/50 (4%)    1/50 (2%)    4/50 (8%)    14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     10.8%        18.7%        15.1%        17.6%       |4.2%         2.2%         8.2%         28.5%        |
|TERMINAL (d)       |     5/40 (13%)   9/45 (20%)   7/44 (16%)   7/42 (17%)  |2/42 (5%)    1/40 (3%)    4/43 (9%)    14/45 (31%)  |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      609         |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.390      P=0.263      P=0.447      P=0.304     |P<0.001 **   P=0.517N     P=0.348      P=0.002 **   |
|POLY 3             |     P=0.368      P=0.212      P=0.376      P=0.262     |P<0.001 **   P=0.507N     P=0.353      P<0.001 **   |
|POLY 1.5           |     P=0.372      P=0.204      P=0.374      P=0.262     |P<0.001 **   P=0.504N     P=0.347      P<0.001 **   |
|POLY 6             |     P=0.378      P=0.225      P=0.388      P=0.273     |P<0.001 **   P=0.510N     P=0.359      P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.358      P=0.263      P=0.447      P=0.259     |P<0.001 **   P=0.517N     P=0.348      P=0.002 **   |
|COCH-ARM / FISHERS |     P=0.397      P=0.194      P=0.380      P=0.277     |P<0.001 **   P=0.500N     P=0.339      P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fatty Change Diffuse                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.4%        |0.0%         6.3%         0.0%         2.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    1/42 (2%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    1/45 (2%)    |
|FIRST INCIDENCE    |     ---          ---          ---          609         |---          512          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.240     |P=0.582N     P=0.124      (e)          P=0.514      |
|POLY 3             |     P=0.039 *    (e)          (e)          P=0.233     |P=0.593N     P=0.121      (e)          P=0.508      |
|POLY 1.5           |     P=0.039 *    (e)          (e)          P=0.233     |P=0.597N     P=0.120      (e)          P=0.505      |
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.237     |P=0.588N     P=0.122      (e)          P=0.513      |
|LOGISTIC REGRESSION|     P=0.044 *    (e)          (e)          P=0.243     |P=0.489      P=0.150      (e)          P=0.514      |
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |P=0.602N     P=0.121      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 13

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Infiltration Cellular Mononuclear Cell                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |8/50 (16%)   9/50 (18%)   12/50 (24%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |17.0%        19.5%        24.6%        20.4%        |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |8/42 (19%)   9/40 (23%)   11/43 (26%)  10/45 (22%)  |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      734 (T)      709          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.494      P=0.455      P=0.246      P=0.460      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.452      P=0.482      P=0.253      P=0.435      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.427      P=0.489      P=0.242      P=0.419      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.482      P=0.474      P=0.266      P=0.455      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.510      P=0.455      P=0.269      P=0.460      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.393      P=0.500      P=0.227      P=0.398      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    6/50 (12%)   3/50 (6%)    9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |8.5%         13.0%        6.1%         18.3%        |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |4/42 (10%)   6/40 (15%)   2/43 (5%)    9/45 (20%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      734 (T)      711          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.118      P=0.338      P=0.486N     P=0.144      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.096      P=0.357      P=0.481N     P=0.132      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.091      P=0.362      P=0.489N     P=0.126      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.103      P=0.351      P=0.472N     P=0.141      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.122      P=0.338      P=0.471N     P=0.144      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.083      P=0.370      P=0.500N     P=0.117      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 14

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Focal                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.6%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     4/40 (10%)   0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.076N     P=0.049N*    P=0.052N     P=0.057N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.077N     P=0.056N     P=0.061N     P=0.064N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.076N     P=0.058N     P=0.062N     P=0.064N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.080N     P=0.054N     P=0.059N     P=0.062N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.076N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.077N     P=0.059N     P=0.059N     P=0.059N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    0/50 (0%)    3/50 (6%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         8.3%         0.0%         6.6%        |2.1%         2.2%         2.1%         4.1%         |
|TERMINAL (d)       |     1/40 (3%)    4/45 (9%)    0/44 (0%)    2/42 (5%)   |1/42 (2%)    1/40 (3%)    1/43 (2%)    2/45 (4%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          609         |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.422      P=0.217      P=0.481N     P=0.316     |P=0.393      P=0.751      P=0.756N     P=0.524      |
|POLY 3             |     P=0.418      P=0.189      P=0.501N     P=0.298     |P=0.379      P=0.756      P=0.753N     P=0.514      |
|POLY 1.5           |     P=0.418      P=0.185      P=0.502N     P=0.298     |P=0.372      P=0.758      P=0.756N     P=0.508      |
|POLY 6             |     P=0.425      P=0.196      P=0.497N     P=0.304     |P=0.388      P=0.754      P=0.750N     P=0.522      |
|LOGISTIC REGRESSION|     P=0.414      P=0.217      (e)          P=0.303     |P=0.393      P=0.751      P=0.756N     P=0.524      |
|COCH-ARM / FISHERS |     P=0.427      P=0.181      P=0.500N     P=0.309     |P=0.360      P=0.753N     P=0.753N     P=0.500      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 15

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis Focal                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    4/50 (8%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         4.3%         8.5%        |4.2%         2.2%         2.1%         2.0%         |
|TERMINAL (d)       |     1/40 (3%)    1/45 (2%)    2/44 (5%)    1/42 (2%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    1/45 (2%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      379         |580          667          732          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.071      P=0.735N     P=0.533      P=0.183     |P=0.462N     P=0.512N     P=0.488N     P=0.487N     |
|POLY 3             |     P=0.073      P=0.753N     P=0.499      P=0.183     |P=0.476N     P=0.512N     P=0.495N     P=0.492N     |
|POLY 1.5           |     P=0.072      P=0.756N     P=0.497      P=0.180     |P=0.481N     P=0.507N     P=0.497N     P=0.495N     |
|POLY 6             |     P=0.076      P=0.748N     P=0.504      P=0.191     |P=0.471N     P=0.517N     P=0.494N     P=0.488N     |
|LOGISTIC REGRESSION|     P=0.086      P=0.735N     P=0.533      P=0.203     |P=0.658N     P=0.423N     P=0.716N     P=0.726N     |
|COCH-ARM / FISHERS |     P=0.073      P=0.753N     P=0.500      P=0.181     |P=0.488N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Tension Lipidosis                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |4/50 (8%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.6%         2.1%         6.3%         2.2%        |8.5%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     4/40 (10%)   1/45 (2%)    1/44 (2%)    1/42 (2%)   |4/42 (10%)   1/40 (3%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      406          733 (T)     |734 (T)      734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.250N     P=0.146N     P=0.465N     P=0.165N    |P=0.051N     P=0.194N     P=0.060N     P=0.055N     |
|POLY 3             |     P=0.265N     P=0.169N     P=0.483N     P=0.188N    |P=0.052N     P=0.185N     P=0.056N     P=0.055N     |
|POLY 1.5           |     P=0.260N     P=0.174N     P=0.491N     P=0.187N    |P=0.053N     P=0.183N     P=0.058N     P=0.058N     |
|POLY 6             |     P=0.267N     P=0.163N     P=0.470N     P=0.184N    |P=0.050N     P=0.187N     P=0.055N     P=0.053N     |
|LOGISTIC REGRESSION|     P=0.225N     P=0.146N     P=0.484N     P=0.165N    |P=0.051N     P=0.194N     (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.244N     P=0.181N     P=0.500N     P=0.181N    |P=0.057N     P=0.181N     P=0.059N     P=0.059N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 16

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic Focal                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         0.0%        |2.1%         2.2%         4.1%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |1/42 (2%)    1/40 (3%)    2/43 (5%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          565          ---          ---         |734 (T)      734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.589N     P=0.504      (e)          (e)         |P=0.309N     P=0.751      P=0.508      P=0.486N     |
|POLY 3             |     P=0.572N     P=0.509      (e)          (e)         |P=0.317N     P=0.756      P=0.511      P=0.492N     |
|POLY 1.5           |     P=0.574N     P=0.505      (e)          (e)         |P=0.324N     P=0.758      P=0.507      P=0.495N     |
|POLY 6             |     P=0.568N     P=0.514      (e)          (e)         |P=0.309N     P=0.754      P=0.516      P=0.487N     |
|LOGISTIC REGRESSION|     P=0.555N     P=0.488      (e)          (e)         |P=0.309N     P=0.751      P=0.508      (e)          |
|COCH-ARM / FISHERS |     P=0.576N     P=0.500      (e)          (e)         |P=0.333N     P=0.753N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    24/50 (48%)  43/50 (86%)  45/50 (90%) |0/50 (0%)    0/50 (0%)    9/50 (18%)   29/50 (58%)  |
|POLY-3 ADJUSTED (b)|     2.2%         50.0%        89.7%        94.9%       |0.0%         0.0%         18.5%        58.4%        |
|TERMINAL (d)       |     1/40 (3%)    24/45 (53%)  41/44 (93%)  40/42 (95%) |0/42 (0%)    0/40 (0%)    9/43 (21%)   28/45 (62%)  |
|FIRST INCIDENCE    |     733 (T)      733 (T)      406          379         |---          ---          734 (T)      578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.003 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.002 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.002 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.002 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.003 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 17

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     603          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.249N     P=0.230N     P=0.237N     P=0.244N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.246N     P=0.232N     P=0.240N     P=0.246N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.244N     P=0.235N     P=0.240N     P=0.245N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.249N     P=0.229N     P=0.238N     P=0.245N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.235N     P=0.242N     P=0.234N     P=0.230N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.242N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.2%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |2/42 (5%)    0/40 (0%)    1/43 (2%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      ---          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.254N     P=0.249N     P=0.492N     P=0.223N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.260N     P=0.242N     P=0.489N     P=0.228N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.265N     P=0.240N     P=0.493N     P=0.232N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.255N     P=0.244N     P=0.484N     P=0.224N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.254N     (e)          P=0.492N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.271N     P=0.247N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 18

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic Focal                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         2.2%         0.0%        |0.0%         0.0%         0.0%         4.1%         |
|TERMINAL (d)       |     1/40 (3%)    0/45 (0%)    1/44 (2%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      ---         |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.464N     P=0.477N     P=0.740N     P=0.490N    |P=0.049 *    (e)          (e)          P=0.254      |
|POLY 3             |     P=0.476N     P=0.493N     P=0.760      P=0.506N    |P=0.043 *    (e)          (e)          P=0.247      |
|POLY 1.5           |     P=0.473N     P=0.496N     P=0.759      P=0.505N    |P=0.042 *    (e)          (e)          P=0.243      |
|POLY 6             |     P=0.478N     P=0.489N     P=0.758N     P=0.504N    |P=0.045 *    (e)          (e)          P=0.252      |
|LOGISTIC REGRESSION|     P=0.464N     (e)          P=0.740N     (e)         |(e)          (e)          (e)          P=0.254      |
|COCH-ARM / FISHERS |     P=0.464N     P=0.500N     P=0.753N     P=0.500N    |P=0.042 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         0.0%         2.2%        |0.0%         2.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    2/45 (4%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    1/40 (3%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      ---          407         |---          734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.618      P=0.265      (e)          P=0.492     |P=0.561N     P=0.490      (e)          (e)          |
|POLY 3             |     P=0.621      P=0.245      (e)          P=0.498     |P=0.578N     P=0.496      (e)          (e)          |
|POLY 1.5           |     P=0.619      P=0.241      (e)          P=0.497     |P=0.577N     P=0.498      (e)          (e)          |
|POLY 6             |     P=0.626      P=0.250      (e)          P=0.501     |P=0.579N     P=0.494      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.644      P=0.265      (e)          P=0.537     |(e)          P=0.490      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.622      P=0.247      (e)          P=0.500     |P=0.576N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 19

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    4/50 (8%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         4.3%         8.9%        |2.1%         2.2%         0.0%         4.1%         |
|TERMINAL (d)       |     0/40 (0%)    2/45 (4%)    2/44 (5%)    4/42 (10%)  |1/42 (2%)    1/40 (3%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      733 (T)     |734 (T)      734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.059      P=0.265      P=0.260      P=0.070     |P=0.362      P=0.751      P=0.495N     P=0.524      |
|POLY 3             |     P=0.055      P=0.245      P=0.236      P=0.057     |P=0.346      P=0.756      P=0.494N     P=0.514      |
|POLY 1.5           |     P=0.056      P=0.241      P=0.235      P=0.057     |P=0.341      P=0.758      P=0.496N     P=0.508      |
|POLY 6             |     P=0.056      P=0.250      P=0.240      P=0.058     |P=0.352      P=0.754      P=0.491N     P=0.522      |
|LOGISTIC REGRESSION|     (e)          P=0.265      P=0.260      P=0.070     |P=0.362      P=0.751      (e)          P=0.524      |
|COCH-ARM / FISHERS |     P=0.061      P=0.247      P=0.247      P=0.059     |P=0.333      P=0.753N     P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/46 (2%)    6/49 (12%)   4/48 (8%)    0/50 (0%)   |0/47 (0%)    1/47 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         12.7%        9.0%         0.0%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    6/45 (13%)   4/42 (10%)   0/42 (0%)   |0/40 (0%)    1/40 (3%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     691          733 (T)      733 (T)      ---         |---          734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.086N     P=0.090      P=0.210      P=0.495N    |P=0.557N     P=0.500      (e)          (e)          |
|POLY 3             |     P=0.092N     P=0.069      P=0.181      P=0.495N    |P=0.569N     P=0.495      (e)          (e)          |
|POLY 1.5           |     P=0.090N     P=0.066      P=0.181      P=0.493N    |P=0.568N     P=0.497      (e)          (e)          |
|POLY 6             |     P=0.091N     P=0.073      P=0.184      P=0.493N    |P=0.570N     P=0.494      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.091N     P=0.070      P=0.184      P=0.475N    |(e)          P=0.500      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.080N     P=0.066      P=0.194      P=0.479N    |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 20

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Erythrophagocytosis                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    0/45 (0%)    0/47 (0%)    2/46 (4%)   |1/50 (2%)    0/46 (0%)    0/49 (0%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         4.6%        |2.1%         0.0%         0.0%         2.2%         |
|TERMINAL (d)       |     1/39 (3%)    0/42 (0%)    0/43 (0%)    1/40 (3%)   |1/42 (2%)    0/39 (0%)    0/43 (0%)    1/42 (2%)    |
|FIRST INCIDENCE    |     733 (T)      ---          ---          485         |734 (T)      ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.182      P=0.485N     P=0.481N     P=0.499     |P=0.543      P=0.515N     P=0.495N     P=0.762      |
|POLY 3             |     P=0.181      P=0.506N     P=0.502N     P=0.486     |P=0.537      P=0.519N     P=0.496N     P=0.753      |
|POLY 1.5           |     P=0.182      P=0.509N     P=0.503N     P=0.484     |P=0.532      P=0.518N     P=0.499N     P=0.749      |
|POLY 6             |     P=0.181      P=0.502N     P=0.498N     P=0.493     |P=0.543      P=0.520N     P=0.492N     P=0.759      |
|LOGISTIC REGRESSION|     P=0.278      (e)          (e)          P=0.588     |P=0.543      (e)          (e)          P=0.762      |
|COCH-ARM / FISHERS |     P=0.185      P=0.516N     P=0.505N     P=0.484     |P=0.525      P=0.521N     P=0.505N     P=0.731      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    1/45 (2%)    4/47 (9%)    0/46 (0%)   |4/50 (8%)    1/46 (2%)    3/49 (6%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.3%         8.9%         0.0%        |8.5%         2.3%         6.2%         2.2%         |
|TERMINAL (d)       |     1/39 (3%)    1/42 (2%)    4/43 (9%)    0/40 (0%)   |4/42 (10%)   1/39 (3%)    3/43 (7%)    1/42 (2%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      ---         |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.343N     P=0.745N     P=0.210      P=0.495N    |P=0.233N     P=0.202N     P=0.487N     P=0.180N     |
|POLY 3             |     P=0.361N     P=0.754      P=0.176      P=0.511N    |P=0.240N     P=0.209N     P=0.488N     P=0.189N     |
|POLY 1.5           |     P=0.358N     P=0.750      P=0.174      P=0.511N    |P=0.249N     P=0.208N     P=0.497N     P=0.196N     |
|POLY 6             |     P=0.358N     P=0.759      P=0.182      P=0.508N    |P=0.230N     P=0.209N     P=0.477N     P=0.181N     |
|LOGISTIC REGRESSION|     P=0.343N     P=0.745N     P=0.210      (e)         |P=0.233N     P=0.202N     P=0.487N     P=0.180N     |
|COCH-ARM / FISHERS |     P=0.347N     P=0.736      P=0.174      P=0.511N    |P=0.262N     P=0.208N     P=0.511N     P=0.208N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 21

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Lumbar                                                                                                               |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/2 (0%)     0/1 (0%)     0/1 (0%)     0/1 (0%)    |0/3 (0%)     1/6 (17%)    2/4 (50%)    1/4 (25%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         18.7%        51.6%        25.2%        |
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/1 (0%)    |0/1 (0%)     1/5 (20%)    2/3 (67%)    1/3 (33%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.541      P=0.814      P=0.500      P=0.718      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.581      P=0.662      P=0.341      P=0.605      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.536      P=0.648      P=0.307      P=0.583      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.637      P=0.688      P=0.399      P=0.639      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.814      P=0.500      P=0.718      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.478      P=0.667      P=0.286      P=0.571      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/2 (0%)     0/1 (0%)     0/1 (0%)     0/1 (0%)    |0/3 (0%)     1/6 (17%)    1/4 (25%)    2/4 (50%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         18.7%        25.8%        50.0%        |
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/1 (0%)    |0/1 (0%)     1/5 (20%)    1/3 (33%)    1/3 (33%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          734 (T)      734 (T)      726          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.200      P=0.814      P=0.718      P=0.365      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.209      P=0.662      P=0.602      P=0.354      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.184      P=0.648      P=0.581      P=0.314      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.247      P=0.688      P=0.633      P=0.420      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.240      P=0.814      P=0.718      P=0.534      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.144      P=0.667      P=0.571      P=0.286      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 22

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.0%         4.1%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/42 (0%)    0/40 (0%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          652          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.098      (e)          P=0.517      P=0.254      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.091      (e)          P=0.508      P=0.247      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.088      (e)          P=0.505      P=0.243      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.095      (e)          P=0.512      P=0.252      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.064      (e)          P=0.379      P=0.254      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.084      (e)          P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/3 (67%)    2/2 (100%)   1/1 (100%)   0/0 (0%)    |4/5 (80%)    1/2 (50%)    3/5 (60%)    4/5 (80%)    |
|POLY-3 ADJUSTED (b)|     66.7%        100.0%       100.0%       0.0%        |84.8%        50.0%        60.0%        80.0%        |
|TERMINAL (d)       |     1/2 (50%)    2/2 (100%)   1/1 (100%)   0/0 (0%)    |4/4 (100%)   1/2 (50%)    1/3 (33%)    4/5 (80%)    |
|FIRST INCIDENCE    |     603          733 (T)      733 (T)      ---         |734 (T)      734 (T)      586          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.583N     P=0.750N     P=0.677N     P=0.495N    |P=0.609N     P=0.362N     P=0.633N     P=0.545N     |
|POLY 3             |     (e)          P=0.577      P=0.691      (e)         |P=0.574      P=0.508N     P=0.445N     P=0.729N     |
|POLY 1.5           |     (e)          P=0.577      P=0.691      (e)         |P=0.557      P=0.528N     P=0.471N     P=0.745N     |
|POLY 6             |     (e)          P=0.577      P=0.691      (e)         |P=0.600      P=0.471N     P=0.398N     P=0.694N     |
|LOGISTIC REGRESSION|     (e)          P=0.750N     P=0.677N     (e)         |P=0.546      P=0.362N     P=0.502N     P=0.545N     |
|COCH-ARM / FISHERS |     P=0.988      P=0.600      P=0.750      P=1.000     |P=0.542      P=0.524N     P=0.500N     P=0.778N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 23

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |580          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.235N     P=0.247N     P=0.230N     P=0.230N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.234N     P=0.246N     P=0.234N     P=0.232N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.237N     P=0.242N     P=0.235N     P=0.234N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.231N     P=0.250N     P=0.233N     P=0.229N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.387N     P=0.180N     P=0.428N     P=0.434N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.242N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Sinus                                                                                                                      |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     691          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.243N     P=0.217N     P=0.224N     P=0.232N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.247N     P=0.231N     P=0.239N     P=0.245N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.245N     P=0.234N     P=0.240N     P=0.244N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.250N     P=0.227N     P=0.236N     P=0.243N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.244N     P=0.237N     P=0.238N     P=0.241N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.242N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 24

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Turbinate                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.4%         4.2%         2.2%         0.0%        |2.1%         0.0%         2.0%         0.0%         |
|TERMINAL (d)       |     1/40 (3%)    1/45 (2%)    1/44 (2%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     661          718          733 (T)      ---         |580          ---          586          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.090N     P=0.459N     P=0.289N     P=0.123N    |P=0.459N     P=0.508N     P=0.754N     P=0.500N     |
|POLY 3             |     P=0.093N     P=0.490N     P=0.311N     P=0.126N    |P=0.452N     P=0.506N     P=0.753N     P=0.494N     |
|POLY 1.5           |     P=0.091N     P=0.494N     P=0.311N     P=0.125N    |P=0.457N     P=0.504N     P=0.756N     P=0.496N     |
|POLY 6             |     P=0.093N     P=0.483N     P=0.308N     P=0.126N    |P=0.446N     P=0.509N     P=0.750N     P=0.491N     |
|LOGISTIC REGRESSION|     P=0.087N     P=0.503N     P=0.304N     P=0.118N    |P=0.798N     P=0.441N     P=0.474      P=0.784N     |
|COCH-ARM / FISHERS |     P=0.086N     P=0.500N     P=0.309N     P=0.121N    |P=0.464N     P=0.500N     P=0.753N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     23/50 (46%)  27/50 (54%)  25/50 (50%)  18/50 (36%) |14/31 (45%)  7/21 (33%)   17/37 (46%)  18/37 (49%)  |
|POLY-3 ADJUSTED (b)|     48.6%        55.8%        53.7%        39.9%       |45.6%        33.3%        46.2%        48.7%        |
|TERMINAL (d)       |     18/40 (45%)  25/45 (56%)  24/44 (55%)  18/42 (43%) |14/30 (47%)  7/21 (33%)   15/34 (44%)  18/36 (50%)  |
|FIRST INCIDENCE    |     649          652          649          733 (T)     |734 (T)      734 (T)      702          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.080N     P=0.487      P=0.568N     P=0.165N    |P=0.297      P=0.256N     P=0.489      P=0.491      |
|POLY 3             |     P=0.121N     P=0.308      P=0.387      P=0.265N    |P=0.308      P=0.279N     P=0.576      P=0.495      |
|POLY 1.5           |     P=0.106N     P=0.293      P=0.391      P=0.249N    |P=0.305      P=0.283N     P=0.574      P=0.490      |
|POLY 6             |     P=0.129N     P=0.331      P=0.398      P=0.267N    |P=0.312      P=0.272N     P=0.580      P=0.504      |
|LOGISTIC REGRESSION|     P=0.106N     P=0.325      P=0.414      P=0.231N    |P=0.315      P=0.256N     P=0.566      P=0.491      |
|COCH-ARM / FISHERS |     P=0.075N     P=0.274      P=0.421      P=0.208N    |P=0.300      P=0.287N     P=0.571      P=0.483      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 25

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa: Gingival                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     36/50 (72%)  36/50 (72%)  34/50 (68%)  33/50 (66%) |31/31 (100%) 21/21 (100%) 37/37 (100%) 36/37 (97%)  |
|POLY-3 ADJUSTED (b)|     75.5%        74.4%        71.8%        71.7%       |100.0%       100.0%       100.0%       97.3%        |
|TERMINAL (d)       |     30/40 (75%)  34/45 (76%)  31/44 (71%)  31/42 (74%) |30/30 (100%) 21/21 (100%) 34/34 (100%) 35/36 (97%)  |
|FIRST INCIDENCE    |     631          652          513          369         |657          734 (T)      683          723          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.298N     P=0.265N     P=0.214N     P=0.236N    |P=0.445N     (e)          (e)          P=0.501N     |
|POLY 3             |     P=0.392N     P=0.546N     P=0.432N     P=0.427N    |P=0.260N     (e)          (e)          P=0.535N     |
|POLY 1.5           |     P=0.353N     P=0.564N     P=0.437N     P=0.399N    |P=0.260N     (e)          (e)          P=0.535N     |
|POLY 6             |     P=0.416N     P=0.518N     P=0.404N     P=0.437N    |P=0.260N     (e)          (e)          P=0.535N     |
|LOGISTIC REGRESSION|     P=0.408N     P=0.479N     P=0.450N     P=0.433N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.272N     P=0.588N     P=0.414N     P=0.333N    |P=0.259N     (e)          (e)          P=0.544N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    7/48 (15%)   2/49 (4%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.2%         15.8%        4.1%         2.1%         |
|TERMINAL (d)       |                                                        |1/42 (2%)    7/39 (18%)   0/42 (0%)    1/44 (2%)    |
|FIRST INCIDENCE    |                                                        |636          734 (T)      586          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.097N     P=0.067      P=0.676N     P=0.482N     |
|POLY 3             |                                                        |P=0.105N     P=0.064      P=0.688N     P=0.502N     |
|POLY 1.5           |                                                        |P=0.109N     P=0.066      P=0.693N     P=0.507N     |
|POLY 6             |                                                        |P=0.101N     P=0.061      P=0.682N     P=0.495N     |
|LOGISTIC REGRESSION|                                                        |P=0.134N     P=0.068      P=0.533      P=0.579N     |
|COCH-ARM / FISHERS |                                                        |P=0.117N     P=0.070      P=0.684      P=0.515N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 26

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |15/50 (30%)  11/48 (23%)  16/49 (33%)  9/48 (19%)   |
|POLY-3 ADJUSTED (b)|                                                        |31.5%        24.8%        33.4%        19.1%        |
|TERMINAL (d)       |                                                        |14/42 (33%)  11/39 (28%)  15/42 (36%)  9/44 (21%)   |
|FIRST INCIDENCE    |                                                        |600          734 (T)      683          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.096N     P=0.316N     P=0.505      P=0.096N     |
|POLY 3             |                                                        |P=0.127N     P=0.313N     P=0.508      P=0.122N     |
|POLY 1.5           |                                                        |P=0.142N     P=0.302N     P=0.494      P=0.131N     |
|POLY 6             |                                                        |P=0.109N     P=0.324N     P=0.525      P=0.111N     |
|LOGISTIC REGRESSION|                                                        |P=0.105N     P=0.309N     P=0.527      P=0.113N     |
|COCH-ARM / FISHERS |                                                        |P=0.166N     P=0.286N     P=0.473      P=0.145N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |7/50 (14%)   0/48 (0%)    4/49 (8%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |14.7%        0.0%         8.4%         0.0%         |
|TERMINAL (d)       |                                                        |6/42 (14%)   0/39 (0%)    3/42 (7%)    0/44 (0%)    |
|FIRST INCIDENCE    |                                                        |600          ---          683          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.030N*    P=0.013N*    P=0.259N     P=0.009N**   |
|POLY 3             |                                                        |P=0.028N*    P=0.010N*    P=0.258N     P=0.008N**   |
|POLY 1.5           |                                                        |P=0.030N*    P=0.010N*    P=0.264N     P=0.008N**   |
|POLY 6             |                                                        |P=0.025N*    P=0.010N*    P=0.251N     P=0.007N**   |
|LOGISTIC REGRESSION|                                                        |P=0.038N*    P=0.011N*    P=0.288N     P=0.012N*    |
|COCH-ARM / FISHERS |                                                        |P=0.037N*    P=0.007N**   P=0.274N     P=0.007N**   |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 27

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    0/48 (0%)    1/49 (2%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         0.0%         2.1%         4.2%         |
|TERMINAL (d)       |                                                        |0/42 (0%)    0/39 (0%)    1/42 (2%)    2/44 (5%)    |
|FIRST INCIDENCE    |                                                        |---          ---          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.096      (e)          P=0.500      P=0.249      |
|POLY 3             |                                                        |P=0.088      (e)          P=0.502      P=0.238      |
|POLY 1.5           |                                                        |P=0.085      (e)          P=0.500      P=0.234      |
|POLY 6             |                                                        |P=0.092      (e)          P=0.505      P=0.243      |
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.500      P=0.249      |
|COCH-ARM / FISHERS |                                                        |P=0.080      (e)          P=0.495      P=0.237      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    4/48 (8%)    0/49 (0%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.1%         8.9%         0.0%         2.1%         |
|TERMINAL (d)       |                                                        |1/42 (2%)    3/39 (8%)    0/42 (0%)    0/44 (0%)    |
|FIRST INCIDENCE    |                                                        |734 (T)      616          ---          578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.308N     P=0.162      P=0.500N     P=0.753N     |
|POLY 3             |                                                        |P=0.324N     P=0.164      P=0.498N     P=0.757N     |
|POLY 1.5           |                                                        |P=0.329N     P=0.165      P=0.500N     P=0.758      |
|POLY 6             |                                                        |P=0.317N     P=0.164      P=0.495N     P=0.751N     |
|LOGISTIC REGRESSION|                                                        |P=0.434N     P=0.169      (e)          P=0.638      |
|COCH-ARM / FISHERS |                                                        |P=0.337N     P=0.168      P=0.505N     P=0.742      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 28

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/49 (6%)    1/50 (2%)    1/49 (2%)   |2/50 (4%)    0/49 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.2%         2.2%         2.2%        |4.2%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    3/45 (7%)    1/44 (2%)    0/42 (0%)   |2/42 (5%)    0/40 (0%)    1/43 (2%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      702         |734 (T)      ---          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.581N     P=0.143      P=0.519      P=0.514     |P=0.254N     P=0.249N     P=0.492N     P=0.223N     |
|POLY 3             |     P=0.585N     P=0.125      P=0.499      P=0.494     |P=0.259N     P=0.246N     P=0.489N     P=0.228N     |
|POLY 1.5           |     P=0.587N     P=0.122      P=0.498      P=0.493     |P=0.263N     P=0.244N     P=0.493N     P=0.232N     |
|POLY 6             |     P=0.579N     P=0.129      P=0.503      P=0.497     |P=0.254N     P=0.247N     P=0.484N     P=0.224N     |
|LOGISTIC REGRESSION|     P=0.597N     P=0.143      P=0.519      P=0.496     |P=0.254N     (e)          P=0.492N     (e)          |
|COCH-ARM / FISHERS |     P=0.585N     P=0.117      P=0.500      P=0.495     |P=0.269N     P=0.253N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    1/49 (2%)    0/50 (0%)   |0/48 (0%)    0/46 (0%)    0/48 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         2.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    2/45 (4%)    1/43 (2%)    0/42 (0%)   |0/41 (0%)    0/38 (0%)    0/43 (0%)    0/44 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.378N     P=0.265      P=0.514      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.384N     P=0.247      P=0.497      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.383N     P=0.245      P=0.497      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.382N     P=0.251      P=0.499      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.265      P=0.514      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.375N     P=0.253      P=0.500      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 29

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/49 (2%)    0/50 (0%)   |5/48 (10%)   6/46 (13%)   7/48 (15%)   11/48 (23%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         2.2%         0.0%        |11.0%        14.0%        14.7%        23.1%        |
|TERMINAL (d)       |     0/40 (0%)    1/45 (2%)    1/43 (2%)    0/42 (0%)   |5/41 (12%)   5/38 (13%)   6/43 (14%)   11/44 (25%)  |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |734 (T)      731          702          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.537N     P=0.523      P=0.514      (e)         |P=0.081      P=0.450      P=0.415      P=0.110      |
|POLY 3             |     P=0.543N     P=0.509      P=0.497      (e)         |P=0.067      P=0.455      P=0.408      P=0.099      |
|POLY 1.5           |     P=0.541N     P=0.507      P=0.497      (e)         |P=0.061      P=0.461      P=0.396      P=0.093      |
|POLY 6             |     P=0.541N     P=0.512      P=0.499      (e)         |P=0.074      P=0.451      P=0.423      P=0.108      |
|LOGISTIC REGRESSION|     (e)          P=0.523      P=0.514      (e)         |P=0.085      P=0.455      P=0.425      P=0.110      |
|COCH-ARM / FISHERS |     P=0.533N     P=0.505      P=0.500      (e)         |P=0.053      P=0.470      P=0.379      P=0.085      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     26/50 (52%)  23/50 (46%)  25/50 (50%)  11/50 (22%) |                                                    |
|POLY-3 ADJUSTED (b)|     55.2%        47.1%        53.9%        23.6%       |                                                    |
|TERMINAL (d)       |     23/40 (58%)  21/45 (47%)  24/44 (55%)  9/42 (21%)  |                                                    |
|FIRST INCIDENCE    |     649          565          705          407         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.177N     P=0.319N     P=0.002N**  |                                                    |
|POLY 3             |     P<0.001N**   P=0.277N     P=0.532N     P<0.001N**  |                                                    |
|POLY 1.5           |     P<0.001N**   P=0.305N     P=0.529N     P<0.001N**  |                                                    |
|POLY 6             |     P<0.001N**   P=0.241N     P=0.515N     P<0.001N**  |                                                    |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.302N     P=0.467N     P=0.002N**  |                                                    |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.345N     P=0.500N     P=0.002N**  |                                                    |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 30

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    0/50 (0%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     14.9%        6.2%         0.0%         4.4%        |                                                    |
|TERMINAL (d)       |     6/40 (15%)   3/45 (7%)    0/44 (0%)    1/42 (2%)   |                                                    |
|FIRST INCIDENCE    |     631          733 (T)      ---          609         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.105N     P=0.120N     P=0.007N**   P=0.079N    |                                                    |
|POLY 3             |     P=0.105N     P=0.148N     P=0.008N**   P=0.086N    |                                                    |
|POLY 1.5           |     P=0.103N     P=0.153N     P=0.008N**   P=0.085N    |                                                    |
|POLY 6             |     P=0.106N     P=0.141N     P=0.008N**   P=0.082N    |                                                    |
|LOGISTIC REGRESSION|     P=0.105N     P=0.150N     P=0.009N**   P=0.084N    |                                                    |
|COCH-ARM / FISHERS |     P=0.101N     P=0.159N     P=0.006N**   P=0.080N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  29/50 (58%)  23/50 (46%)  14/50 (28%) |                                                    |
|POLY-3 ADJUSTED (b)|     63.0%        58.1%        48.9%        29.9%       |                                                    |
|TERMINAL (d)       |     26/40 (65%)  25/45 (56%)  21/44 (48%)  12/42 (29%) |                                                    |
|FIRST INCIDENCE    |     603          61           513          369         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001N**   P=0.273N     P=0.055N     P<0.001N**  |                                                    |
|POLY 3             |     P<0.001N**   P=0.385N     P=0.117N     P<0.001N**  |                                                    |
|POLY 1.5           |     P<0.001N**   P=0.414N     P=0.119N     P<0.001N**  |                                                    |
|POLY 6             |     P<0.001N**   P=0.345N     P=0.107N     P<0.001N**  |                                                    |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.494N     P=0.119N     P<0.001N**  |                                                    |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500N     P=0.115N     P<0.001N**  |                                                    |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 31

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     17/50 (34%)  12/50 (24%)  9/50 (18%)   13/49 (27%) |11/49 (22%)  15/49 (31%)  11/50 (22%)  21/50 (42%)  |
|POLY-3 ADJUSTED (b)|     35.4%        24.6%        18.8%        27.9%       |23.1%        31.5%        22.5%        42.7%        |
|TERMINAL (d)       |     12/40 (30%)  10/45 (22%)  7/44 (16%)   10/42 (24%) |8/42 (19%)   11/40 (28%)  10/43 (23%)  20/45 (44%)  |
|FIRST INCIDENCE    |     550          565          406          407         |580          512          702          726          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.402N     P=0.131N     P=0.046N*    P=0.244N    |P=0.052      P=0.225      P=0.564N     P=0.049 *    |
|POLY 3             |     P=0.425N     P=0.173N     P=0.054N     P=0.288N    |P=0.027 *    P=0.247      P=0.568N     P=0.032 *    |
|POLY 1.5           |     P=0.420N     P=0.180N     P=0.055N     P=0.287N    |P=0.026 *    P=0.248      P=0.569N     P=0.031 *    |
|POLY 6             |     P=0.427N     P=0.162N     P=0.052N     P=0.281N    |P=0.027 *    P=0.246      P=0.569N     P=0.032 *    |
|LOGISTIC REGRESSION|     P=0.396N     P=0.189N     P=0.054N     P=0.276N    |P=0.016 *    P=0.270      P=0.569      P=0.027 *    |
|COCH-ARM / FISHERS |     P=0.405N     P=0.189N     P=0.055N     P=0.278N    |P=0.026 *    P=0.246      P=0.574N     P=0.031 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   2/50 (4%)    3/50 (6%)    8/49 (16%)  |5/49 (10%)   7/49 (14%)   4/50 (8%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     16.5%        4.1%         6.3%         16.4%       |10.4%        14.4%        8.1%         4.1%         |
|TERMINAL (d)       |     2/40 (5%)    0/45 (0%)    2/44 (5%)    2/42 (5%)   |0/42 (0%)    1/40 (3%)    0/43 (0%)    1/45 (2%)    |
|FIRST INCIDENCE    |     30           652          15           16          |580          512          652          726          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.211      P=0.045N*    P=0.100N     P=0.599N    |P=0.085N     P=0.368      P=0.467N     P=0.204N     |
|POLY 3             |     P=0.214      P=0.046N*    P=0.108N     P=0.602N    |P=0.088N     P=0.389      P=0.483N     P=0.208N     |
|POLY 1.5           |     P=0.211      P=0.048N*    P=0.106N     P=0.602     |P=0.088N     P=0.386      P=0.484N     P=0.208N     |
|POLY 6             |     P=0.218      P=0.045N*    P=0.108N     P=0.590N    |P=0.089N     P=0.391      P=0.483N     P=0.209N     |
|LOGISTIC REGRESSION|     P=0.285      P=0.048N*    P=0.059N     P=0.564N    |P=0.380N     P=0.445      P=0.507      P=0.444N     |
|COCH-ARM / FISHERS |     P=0.201      P=0.046N*    P=0.100N     P=0.590     |P=0.088N     P=0.380      P=0.487N     P=0.210N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 32

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   7/50 (14%)   2/49 (4%)   |10/49 (20%)  9/49 (18%)   11/50 (22%)  8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     2.2%         10.3%        15.1%        4.4%        |21.6%        19.7%        22.6%        16.2%        |
|TERMINAL (d)       |     1/40 (3%)    4/45 (9%)    7/44 (16%)   2/42 (5%)   |10/42 (24%)  9/40 (23%)   11/43 (26%)  7/45 (16%)   |
|FIRST INCIDENCE    |     733 (T)      565          733 (T)      733 (T)     |734 (T)      734 (T)      734 (T)      690          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.448N     P=0.130      P=0.044 *    P=0.517     |P=0.281N     P=0.548N     P=0.525      P=0.335N     |
|POLY 3             |     P=0.475N     P=0.112      P=0.030 *    P=0.489     |P=0.301N     P=0.512N     P=0.553      P=0.341N     |
|POLY 1.5           |     P=0.472N     P=0.108      P=0.029 *    P=0.488     |P=0.321N     P=0.508N     P=0.540      P=0.357N     |
|POLY 6             |     P=0.468N     P=0.119      P=0.031 *    P=0.494     |P=0.276N     P=0.517N     P=0.566      P=0.321N     |
|LOGISTIC REGRESSION|     P=0.469N     P=0.102      P=0.044 *    P=0.517     |P=0.263N     P=0.548N     P=0.525      P=0.316N     |
|COCH-ARM / FISHERS |     P=0.456N     P=0.102      P=0.030 *    P=0.492     |P=0.350N     P=0.500N     P=0.521      P=0.379N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.3%         0.0%        |4.2%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    2/44 (5%)    0/42 (0%)   |1/42 (2%)    0/40 (0%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |711          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.700N     (e)          P=0.260      (e)         |P=0.229N     P=0.250N     P=0.232N     P=0.223N     |
|POLY 3             |     P=0.713N     (e)          P=0.236      (e)         |P=0.237N     P=0.242N     P=0.231N     P=0.229N     |
|POLY 1.5           |     P=0.710N     (e)          P=0.235      (e)         |P=0.238N     P=0.240N     P=0.233N     P=0.232N     |
|POLY 6             |     P=0.712N     (e)          P=0.240      (e)         |P=0.235N     P=0.245N     P=0.228N     P=0.224N     |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.260      (e)         |P=0.238N     P=0.241N     P=0.235N     P=0.235N     |
|COCH-ARM / FISHERS |     P=0.697N     (e)          P=0.247      (e)         |P=0.242N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 33

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.1%         |
|TERMINAL (d)       |     0/40 (0%)    0/45 (0%)    0/44 (0%)    0/42 (0%)   |0/42 (0%)    0/40 (0%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.049 *    (e)          (e)          P=0.254      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.247      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.243      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.252      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.254      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         6.5%         8.6%        |                                                    |
|TERMINAL (d)       |     1/40 (3%)    1/45 (2%)    3/44 (7%)    1/42 (2%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      485         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.087      P=0.735N     P=0.340      P=0.189     |                                                    |
|POLY 3             |     P=0.085      P=0.753N     P=0.304      P=0.178     |                                                    |
|POLY 1.5           |     P=0.084      P=0.756N     P=0.303      P=0.176     |                                                    |
|POLY 6             |     P=0.088      P=0.748N     P=0.310      P=0.186     |                                                    |
|LOGISTIC REGRESSION|     P=0.092      P=0.735N     P=0.340      P=0.191     |                                                    |
|COCH-ARM / FISHERS |     P=0.089      P=0.753N     P=0.309      P=0.181     |                                                    |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 34

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     25/45 (56%)  35/47 (74%)  25/39 (64%)  20/44 (45%) |28/49 (57%)  25/48 (52%)  26/50 (52%)  33/50 (66%)  |
|POLY-3 ADJUSTED (b)|     55.9%        74.5%        67.1%        46.4%       |58.5%        53.2%        52.5%        66.7%        |
|TERMINAL (d)       |     20/39 (51%)  30/42 (71%)  23/34 (68%)  16/39 (41%) |24/42 (57%)  19/39 (49%)  20/43 (47%)  29/45 (64%)  |
|FIRST INCIDENCE    |     30           61           15           16          |600          512          652          690          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.041N*    P=0.105      P=0.350      P=0.229N    |P=0.262      P=0.479N     P=0.374N     P=0.364      |
|POLY 3             |     P=0.032N*    P=0.048 *    P=0.210      P=0.248N    |P=0.132      P=0.380N     P=0.350N     P=0.264      |
|POLY 1.5           |     P=0.031N*    P=0.046 *    P=0.230      P=0.246N    |P=0.126      P=0.380N     P=0.361N     P=0.256      |
|POLY 6             |     P=0.031N*    P=0.051      P=0.200      P=0.245N    |P=0.140      P=0.385N     P=0.338N     P=0.275      |
|LOGISTIC REGRESSION|     P=0.022N*    P=0.040 *    P=0.298      P=0.186N    |P=0.108      P=0.359N     P=0.375N     P=0.274      |
|COCH-ARM / FISHERS |     P=0.028N*    P=0.046 *    P=0.284      P=0.229N    |P=0.119      P=0.384N     P=0.378N     P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/45 (9%)    6/47 (13%)   6/39 (15%)   5/44 (11%)  |4/49 (8%)    4/48 (8%)    4/50 (8%)    7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     9.3%         13.3%        16.9%        12.4%       |8.6%         9.0%         8.2%         14.1%        |
|TERMINAL (d)       |     4/39 (10%)   6/42 (14%)   6/34 (18%)   5/39 (13%)  |3/42 (7%)    4/39 (10%)   4/43 (9%)    6/45 (13%)   |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |711          734 (T)      734 (T)      578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.540      P=0.416      P=0.284      P=0.500     |P=0.216      P=0.603      P=0.628N     P=0.305      |
|POLY 3             |     P=0.498      P=0.402      P=0.258      P=0.463     |P=0.203      P=0.614      P=0.620N     P=0.297      |
|POLY 1.5           |     P=0.504      P=0.400      P=0.264      P=0.467     |P=0.192      P=0.621      P=0.624N     P=0.288      |
|POLY 6             |     P=0.502      P=0.404      P=0.258      P=0.467     |P=0.216      P=0.606      P=0.616N     P=0.309      |
|LOGISTIC REGRESSION|     P=0.540      P=0.416      P=0.284      P=0.500     |P=0.187      P=0.607      P=0.613N     P=0.241      |
|COCH-ARM / FISHERS |     P=0.532      P=0.398      P=0.281      P=0.486     |P=0.176      P=0.631      P=0.631N     P=0.274      |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 35

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/45 (0%)    0/47 (0%)    0/39 (0%)    0/44 (0%)   |0/49 (0%)    0/48 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.1%         |
|TERMINAL (d)       |     0/39 (0%)    0/42 (0%)    0/34 (0%)    0/39 (0%)   |0/42 (0%)    0/39 (0%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.050      (e)          (e)          P=0.254      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.249      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.246      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.253      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.254      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.253      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    2/50 (4%)    7/50 (14%)   11/50 (22%)  |
|POLY-3 ADJUSTED (b)|                                                        |6.4%         4.3%         14.4%        22.4%        |
|TERMINAL (d)       |                                                        |3/42 (7%)    1/40 (3%)    7/43 (16%)   10/45 (22%)  |
|FIRST INCIDENCE    |                                                        |734 (T)      512          734 (T)      723          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.005 **   P=0.516N     P=0.167      P=0.031 *    |
|POLY 3             |                                                        |P=0.003 **   P=0.503N     P=0.172      P=0.024 *    |
|POLY 1.5           |                                                        |P=0.002 **   P=0.502N     P=0.166      P=0.022 *    |
|POLY 6             |                                                        |P=0.003 **   P=0.504N     P=0.178      P=0.027 *    |
|LOGISTIC REGRESSION|                                                        |P=0.003 **   P=0.474N     P=0.167      P=0.032 *    |
|COCH-ARM / FISHERS |                                                        |P=0.002 **   P=0.500N     P=0.159      P=0.020 *    |
|=================================================================================================================================|
       Date:  09/24/99                           EXPERIMENT: 88120 TEST: 04                                            Page 36

Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -            P,P'-DICHLORODIPHENYL SULFONE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         0.0%         0.0%         4.1%         |
|TERMINAL (d)       |                                                        |0/42 (0%)    0/40 (0%)    0/43 (0%)    2/45 (4%)    |
|FIRST INCIDENCE    |                                                        |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.049 *    (e)          (e)          P=0.254      |
|POLY 3             |                                                        |P=0.043 *    (e)          (e)          P=0.247      |
|POLY 1.5           |                                                        |P=0.042 *    (e)          (e)          P=0.243      |
|POLY 6             |                                                        |P=0.045 *    (e)          (e)          P=0.252      |
|LOGISTIC REGRESSION|                                                        |(e)          (e)          (e)          P=0.254      |
|COCH-ARM / FISHERS |                                                        |P=0.042 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 PPM        30 PPM       100 PPM      300 PPM     |0 PPM        30 PPM       100 PPM      300 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus: Endometrium                                                                                                              |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |41/50 (82%)  44/50 (88%)  48/50 (96%)  47/50 (94%)  |
|POLY-3 ADJUSTED (b)|                                                        |84.5%        90.6%        96.8%        94.1%        |
|TERMINAL (d)       |                                                        |37/42 (88%)  38/40 (95%)  43/43 (100%) 43/45 (96%)  |
|FIRST INCIDENCE    |                                                        |580          512          586          578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.489      P=0.165      P=0.096      P=0.299      |
|POLY 3             |                                                        |P=0.112      P=0.258      P=0.029 *    P=0.103      |
|POLY 1.5           |                                                        |P=0.084      P=0.273      P=0.028 *    P=0.082      |
|POLY 6             |                                                        |P=0.166      P=0.237      P=0.031 *    P=0.138      |
|LOGISTIC REGRESSION|                                                        |P=0.143      P=0.213      P=0.060      P=0.116      |
|COCH-ARM / FISHERS |                                                        |P=0.060      P=0.288      P=0.026 *    P=0.061      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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