TDMS Study 88122-06 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: Battelle Columbus ELMIRON DATE: 06/12/01 EXPERIMENT: 88122 TEST: 06 TIME: 09:10:32 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C88122 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41 LAB: BATTELLE COLUMBUS LABORATORY ELMIRON DATE: 06/12/01 EXPERIMENT: 88122 TEST: 06 TIME: 9:18:11 SPECIES: RATS, FISCHER 344 TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: C88122 CONT: NO1-ES-55388 CAS: 37319-17-8 MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE TWO YEAR ORAL GAVAGE STUDY OF ELMIRON ========================================================================================================== WEEK 0 MG/KG 14 MG/KG 42 MG/KG 126 MG/KG ---------------- ---------------- ---------------- ---------------- AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. (GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) ========================================================================================================= B 104.8 50 104.9 100.1 50 104.7 99.9 50 104.0 99.2 50 1 104.8 50 104.9 100.1 50 104.7 99.9 50 104.0 99.2 50 5 221.4 50 221.7 100.1 50 221.9 100.2 50 216.2 97.7 50 9 284.4 50 288.9 101.6 50 290.2 102.0 50 287.0 100.9 50 13 331.1 50 331.3 100.1 50 335.5 101.3 50 332.3 100.4 50 17 356.2 49 360.0 101.1 50 362.7 101.8 50 360.9 101.3 50 21 379.1 49 383.8 101.2 49 387.6 102.2 50 384.7 101.5 49 25 404.4 49 408.1 100.9 49 411.6 101.8 50 407.2 100.7 48 29 418.8 49 427.0 102.0 49 429.8 102.6 50 423.2 101.1 48 33 426.4 49 437.9 102.7 48 441.1 103.4 50 434.9 102.0 48 37 435.6 49 449.5 103.2 48 452.6 103.9 50 448.0 102.8 47 41 445.8 49 461.5 103.5 48 462.4 103.7 50 459.3 103.0 46 45 454.3 49 460.5 101.4 48 467.8 103.0 50 465.5 102.5 46 49 467.0 49 473.2 101.3 47 475.3 101.8 50 475.0 101.7 46 53 471.3 49 479.3 101.7 47 479.0 101.6 50 475.0 100.8 45 57 479.4 49 487.1 101.6 47 486.5 101.5 50 484.1 101.0 45 61 483.6 49 489.7 101.3 47 494.0 102.2 49 486.4 100.6 45 65 480.4 49 490.0 102.0 47 491.7 102.4 49 488.8 101.7 44 69 483.6 48 488.6 101.0 47 493.4 102.0 48 489.5 101.2 43 73 482.1 46 493.1 102.3 45 493.1 102.3 46 492.2 102.1 42 77 473.7 43 489.6 103.4 44 489.6 103.4 43 488.9 103.2 42 81 477.6 42 491.0 102.8 43 495.5 103.7 42 492.7 103.2 42 85 479.6 40 491.9 102.6 41 493.2 102.8 37 490.2 102.2 42 89 470.7 39 489.2 103.9 41 492.4 104.6 37 484.7 103.0 41 93 479.9 36 493.5 102.8 39 495.0 103.1 34 492.7 102.7 38 97 482.9 35 497.1 102.9 37 487.9 101.0 34 482.8 100.0 35 101 473.0 32 484.4 102.4 36 490.0 103.6 27 471.1 99.6 32 TERM. SAC. 26 29 25 28 ========================================================================================================== (A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE. (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT. (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK. (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK IS LESS THAN THE NUMBER OF ANIMALS SURVIVING. MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE TWO YEAR ORAL GAVAGE STUDY OF ELMIRON ========================================================================================================== WEEK 0 MG/KG 28 MG/KG 84 MG/KG 252 MG/KG ---------------- ---------------- ---------------- ---------------- AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. (GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) ========================================================================================================= B 93.3 50 92.9 99.6 50 93.6 100.3 50 93.1 99.8 50 1 93.3 50 92.9 99.6 50 93.6 100.3 50 93.1 99.8 50 5 147.0 50 146.3 99.5 50 147.5 100.3 50 146.2 99.5 50 9 173.3 50 170.3 98.3 50 172.6 99.6 50 171.7 99.1 50 13 185.8 50 179.2 96.4 50 186.4 100.3 50 183.7 98.9 50 17 194.8 50 190.6 97.8 50 192.7 98.9 49 191.8 98.5 49 21 200.2 50 200.8 100.3 50 199.1 99.5 49 198.8 99.3 48 25 212.3 50 209.5 98.7 50 208.5 98.2 49 207.5 97.7 48 29 217.2 49 214.6 98.8 49 215.4 99.2 49 216.9 99.9 48 33 226.5 49 219.9 97.1 49 219.5 96.9 49 218.7 96.6 47 37 233.7 49 223.9 95.8 49 227.0 97.1 49 224.8 96.2 47 41 240.0 49 235.6 98.2 49 235.5 98.1 49 230.7 96.1 46 45 245.4 49 237.0 96.6 49 240.5 98.0 49 237.5 96.8 46 49 254.8 49 247.6 97.2 48 251.1 98.5 49 248.1 97.4 45 53 258.7 49 250.0 96.6 48 257.5 99.5 49 255.3 98.7 45 57 268.6 49 260.1 96.8 48 268.4 99.9 48 266.3 99.1 44 61 275.7 48 268.3 97.3 48 275.0 99.7 47 274.0 99.4 44 65 281.8 47 277.4 98.4 48 286.0 101.5 47 281.7 100.0 44 69 292.0 46 283.7 97.2 47 290.5 99.5 46 288.1 98.7 44 73 293.9 46 290.2 98.7 47 296.8 101.0 44 291.9 99.3 43 77 299.4 45 292.3 97.6 45 296.6 99.1 44 292.1 97.6 41 81 304.5 44 298.2 97.9 44 306.8 100.8 42 296.0 97.2 41 85 307.8 44 304.1 98.8 43 309.3 100.5 42 298.5 97.0 40 89 314.6 40 306.6 97.5 42 310.6 98.7 41 302.5 96.2 39 93 313.8 38 310.4 98.9 41 311.3 99.2 41 303.2 96.6 38 97 327.2 36 316.9 96.9 39 316.2 96.6 35 311.5 95.2 33 101 319.7 34 313.5 98.1 36 316.0 98.8 32 309.8 96.9 31 TERM. SAC. 30 31 28 27 ========================================================================================================== (A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE. (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT. (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK. (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.