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TDMS Study 88122-07 Pathology Tables

NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01
Route: GAVAGE                                                                                                     Time: 15:23:02

                                                          final#1/Mice




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  37319-17-8

       Lock Date:  04/14/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3|             
                                           | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  I  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |          1                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  I  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             3                                                            |             
      Inflammation, Acute                  |                                                                4         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   3                                                      |             
      Basophilic Focus                     |       X                                   X  X  X                        |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |          X                          X  X     X                          X|             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                | 1     1        1  1  1     1  1        1  2  1  1  1  1  1  1  1  1  1  1|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +  +  +  +        +  +        +  +  +     +     +  +  +      |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation, Chronic Active |                3                                                         |             
      Fat, Necrosis                        |             3     2  2        2  3        2  2  2     2     2  2  2      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3|             
                                           | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Atrophy                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Artery, Inflammation                 |                3                                                         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation, Chronic Active |                3                                                         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |    +                                                                     |             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                3                                                         |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                         1                                      1         |             
      Hypertrophy                          |                                                                1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3|             
                                           | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Pars Distalis, Hyperplasia           |                   3  1                 2  3  2              1  1     2   |             
      Pars Intermedia, Hypertrophy         |                                              2                           |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  M  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                                         |             
      Cyst                                 |             4  3  2                       2  1  2                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           3                              |             
      Hydrometra                           |             4     3  4     1        2  3  3        3  2  2        3  3  3|             
      Hyperplasia, Cystic                  |       3                                            2        2  1         |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                                +                 +               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |                                                    4                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                 4  3           4         |             
      Infiltration Cellular, Plasma Cell   |                            3                                             |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3|             
                                           | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3           1                       1                       1         |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Hyperplasia, Lymphoid                |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             1           1                          2     1               |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Artery, Inflammation, Chronic Active |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                            1  1                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 2| 3| 5| 2| 2| 2| 2| 3| 3| 6| 3| 3| 2| 3| 2| 3| 2| 3| 3| 2| 3| 3|             
                                           | 9| 5| 0| 9| 0| 6| 9| 9| 9| 9| 0| 6| 7| 0| 0| 9| 0| 9| 0| 9| 0| 0| 9| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                   1                                2                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |          1  1  1     1        1     1     1     1  2     1               |             
      Artery, Inflammation, Chronic Active |                2                                                         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                3                                                         |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3|            |
                                           | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  +  A  +  A  +  A  +  M  +  +  I  +  +  A|  39        |
      Degeneration, Hyaline                |                               1                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  I  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  A|  41        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  A|  41        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  A|  43        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  A|  42        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                      X   |      5     |
      Cyst                                 | 2                                                                        |      1  2.0|
      Eosinophilic Focus                   |             X              X  X                          X  X            |     10     |
      Fatty Change                         |                            1     1        1                             4|      4  1.8|
      Hematopoietic Cell Proliferation     |             2              1                                3            |      3  2.0|
      Infarct                              |          4                                                               |      1  4.0|
      Inflammation, Chronic                | 1  1  1  1  1  1  1  1  1  1  1        1  1  1     1  1  1  1  1  1  1   |     40  1.0|
      Mineralization                       |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +        +  +  +     +  +  +  +  +           +  +  +  +     +  +  +     +|  30        |
      Inflammation, Suppurative            |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3|            |
                                           | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Fat, Necrosis                        | 2        2  4  2     2  2  3  2  3           3  2  2  2     2  2  2     2|     29  2.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |             3                                                            |      1  3.0|
      Inflammation, Acute                  |             3                                                            |      1  3.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Basophilic Focus                     |                X                                                         |      1     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Squamous                | 1                                      1                                 |      2  1.0|
      Ulcer                                | 2        3                                                              2|      3  2.3|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
      Mineralization                       |                                                                         2|      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                         +|   2        |
      Aorta, Mineralization                |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                         1|      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |             3                                                            |      1  3.0|
      Hyperplasia                          |    1                                               1        1            |      5  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3|            |
                                           | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  I  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  I  M  +|  37        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|  48        |
      Hyperplasia                          |                                                          2               |      1  2.0|
      Pars Distalis, Hyperplasia           |                      3  2                    2                           |     11  2.0|
      Pars Intermedia, Hypertrophy         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  M  +  +  +  +  +  M  +|  39        |
      Inflammation, Chronic Active         |                                                                   1      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                            2        1     2              2               |     10  2.1|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hydrometra                           |    4  3     1  3  2     4  2           3     2     2        3  3  2  2   |     27  2.7|
      Hyperplasia, Cystic                  | 2                    2        2                                         2|      8  2.0|
      Inflammation, Suppurative            |                         2     1                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3|            |
                                           | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                          +                    +                        |   6        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  M  M  +  +  M  +  M  +  M  +  M  M  +  M  +  M  +  +  +  +  M|  33        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.7|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hematopoietic Cell Proliferation     | 2        2  4        3                       1              4            |     10  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  M|  43        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   2        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 2| 2| 4| 0| 2| 2| 2| 3| 1| 3| 1| 8| 3| 8| 3| 2| 2| 3| 2| 3| 3| 3| 2| 3|            |
                                           | 1| 9| 9| 7| 3| 9| 9| 9| 0| 7| 0| 1| 3| 0| 3| 0| 3| 9| 0| 9| 0| 0| 0| 9| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                   1        3                             2               |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      1                          2                        |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A|  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Atrophy                              |                                                 1                        |      1  1.0|
      Hyperplasia                          |                                           1                              |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hydronephrosis                       |          4                                                               |      1  4.0|
      Mineralization                       | 2           1              1                                             |      3  1.3|
      Nephropathy                          |             3        1                 1           1  1  1        1  1  2|     19  1.2|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  M|  43        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3|             
                                           | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  A  +  +  +|             
      Cyst                                 |                                     1                                    |             
      Degeneration, Hyaline                | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Myxomatous Change                    |                                                          1               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X  X                 X                                            X|             
      Clear Cell Focus                     |    X                                                                     |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |       X           X                    X                    X            |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |    1        2                             2              2               |             
      Inflammation, Chronic                | 1  1  1  1  1  1  1  2  1  1     1  1  1  3  1     1  1  1  1     1  1  1|             
      Tension Lipidosis                    |                            X                                             |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +     +     +  +  +     +  +        +     +  +  +  +     +  +  +     +  +|             
      Fat, Necrosis                        | 2     2     2  3  2     2  2        2     2  2  2  2     1  2  2     1  3|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3|             
                                           | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Basophilic Focus                     |                                                       X                  |             
      Lipomatosis                          |    4                                                                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Basophilic Focus                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Squamous                |                            1                                             |             
      Inflammation, Acute                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
      Necrosis                             |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                 1                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |             2                                                            |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          | 2                                   2                                    |             
      Hypertrophy                          |       1                                                     1     1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +|             
      Pars Distalis, Hyperplasia           | 3        2  2  2                                                        2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3|             
                                           | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis                             |                                                                          |             
      Follicular Cell, Hyperplasia         |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                          2               |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2              3        2     2  2     2  1        1     2               |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |             3  1  1     2     2     3     3     2  2              1     2|             
      Hyperplasia, Cystic                  | 2                    2           1  4                                2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                     +                          +        +|             
      Bronchial, Hyperplasia, Lymphoid     |                                     4                                    |             
      Mediastinal, Hyperplasia, Lymphoid   |                                     4                                    |             
      Renal, Hyperplasia, Lymphoid         |                                     4                                    |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  M  +  M  +  M  +  +  +  M  +  +  +  +  +  +  M  +  M  +|             
      Hyperplasia, Lymphoid                |                                     4                                    |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                     4                                    |             
      Infiltration Cellular, Histiocyte    |    1     1           1        1  1        1  2     1     1  1     1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3|             
                                           | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Congestion                           |                                           3                              |             
      Hematopoietic Cell Proliferation     |             4  1              4  1        1     3        4              1|             
      Hyperplasia, Lymphoid                |                                     2     2        3                     |             
      Infiltration Cellular, Histiocyte    |                                                    1                     |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  M  M  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Necrosis, Fatty |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                           1                              |             
      Inflammation, Chronic Active         |                         1                                                |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              2                    1      |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 2| 8| 2| 2| 8| 2| 2| 3| 3| 3|             
                                           | 0| 9| 9| 9| 3| 0| 0| 0| 9| 0| 9| 0| 9| 9| 0| 9| 1| 9| 9| 1| 9| 2| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                    1                     |             
      Olfactory Epithelium, Metaplasia     |       1                                                           3      |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                +         |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2                                    |             
      Hyperplasia                          |             1        3                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |             2                                                            |             
      Mineralization                       |                                                          2               |             
      Nephropathy                          |    1        1  1  1                 1     1  1  1                 1      |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2|            |
                                           | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  A  +  +  +  +  +  +  A  A  +  +  +  +  +  A  A  +  M  +|  40        |
      Cyst                                 |          1                                                               |      2  1.0|
      Degeneration, Hyaline                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|  45        |
      Myxomatous Change                    |                                     1                                   1|      3  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  A  A  +  +  +  +  +  A  A  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|  44        |
      Hyperplasia, Lymphoid                |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                      3   |      1  3.0|
      Basophilic Focus                     |                                                    X                     |      6     |
      Clear Cell Focus                     |          X                                            X              X   |      4     |
      Cyst                                 |                                                                      2   |      1  2.0|
      Eosinophilic Focus                   |       X                                         X                        |      6     |
      Fatty Change                         |                                                                1        1|      2  1.0|
      Hematopoietic Cell Proliferation     |             1                                1                    1      |      7  1.4|
      Inflammation, Chronic                |    1  1  1                 1  1  1  2        1  1  1  1  1        1  2  1|     37  1.1|
      Tension Lipidosis                    |             X                                                            |      2     |
      Bile Duct, Hyperplasia               | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2|            |
                                           | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |    +  +  +        +        +  +     +  +     +  +  +  +  +  +     +  +  +|  34        |
      Fat, Necrosis                        |    2  2  2        1        2  3     2        2  2  2  2  3  3     2  2  2|     33  2.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|  45        |
      Basophilic Focus                     |                                                    X                     |      2     |
      Lipomatosis                          |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                        X                                 |      1     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Squamous                |                                                                2         |      2  1.5|
      Inflammation, Acute                  |                                           1                              |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|  45        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
      Inflammation, Chronic Active         | 1                                                                    2   |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2                                                            |      3  2.0|
      Hypertrophy                          |                                                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2|            |
                                           | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Islets, Pancreatic                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  A  +  +  +  +|  38        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |          2              2           2                                    |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             |                      3                                                   |      1  3.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|  44        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  I|  46        |
      Cyst                                 |       2                                                  2           2   |     12  1.9|
      Thrombosis                           |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    2                                                                     |      1  2.0|
      Hydrometra                           |       3  2        3     4        1              2  2  4  3           2   |     21  2.3|
      Hyperplasia, Cystic                  | 2  3                                2                    2               |      9  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2|            |
                                           | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node                              | +              +  +                    +  +  +              +            |  10        |
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +|  38        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infiltration Cellular, Plasma Cell   |                                                          3               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  A  +  +  +  +  +  +  M  A  +  +  +  +  +  +  A  +  +  +|  44        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    | 1     1  1  1        2     2        2        1  2     1  1              1|     23  1.2|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    2        3              1  1  1     2     2        1     2     1     1|     19  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Infiltration Cellular, Histiocyte    |          1                                            1                  |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M|  38        |
      Necrosis                             |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                      3   |      1  3.0|
      Inflammation, Chronic Active         |                                                                      3   |      1  3.0|
      Subcutaneous Tissue, Necrosis, Fatty |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2|            |
                                           | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
      Fibrous Osteodystrophy               | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Thrombosis                           |                                              2                           |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                              2                           |      3  1.7|
      Mediastinum, Inflammation, Acute     |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Metaplasia, Squamous                 |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  M  M  M  M  M|  41        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |                         3                                                |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 4| 7| 0| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 5| 8| 3| 1| 3| 2| 2| 3| 2| 4| 8| 2| 3| 3| 2| 2| 1| 4| 2| 0| 2|            |
                                           | 0| 0| 0| 9| 5| 5| 0| 8| 0| 9| 9| 0| 9| 1| 1| 9| 0| 0| 9| 9| 1| 2| 9| 3| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Infarct                              |                                                                          |      1  2.0|
      Mineralization                       |                                                             1            |      2  1.5|
      Nephropathy                          |             2                 1     1        1     1  1  1              1|     17  1.1|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                           A                              |            |
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                           +                              |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3|             
                                           | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  A  M  A  +  +  A  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration, Hyaline                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Myxomatous Change                    |             1  1     1  1  1              1  1                       1   |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                               2                                          |             
      Necrosis                             |                                                                4         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                                                     |             
      Basophilic Focus                     |                      X     X           X                    X            |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X                    X     X     X           X                       X   |             
      Fatty Change                         |                                           1                              |             
      Hematopoietic Cell Proliferation     | 1  1                                1                                    |             
      Inflammation, Chronic                | 1  1  2  1  1  1  2  1  1  1  1  1     1  1     1  1     1  2     1  1  1|             
      Mineralization                       |                                                                          |             
      Tension Lipidosis                    |                         X                                                |             
      Centrilobular, Degeneration          |                   2                                                      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3|             
                                           | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Mesentery                               |                +  +  +     +           +  +     +  +  +  +  +  +  +  +  +|             
      Fat, Necrosis                        |                2     2     3           2  2     2  2  2  2  2  3  1  2  2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                   1      |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          |                1           1                                             |             
      Hypertrophy                          |                               1  1                                1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  I  +  +  +  +  M  +  M  I  +  +  +  M  +  +  M  +  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |             1     2     1                                   2            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3|             
                                           | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M  I  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Cyst                                 | 4        3                                         2     3               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |    3        3           4     1        4  2     3     2              2  1|             
      Hyperplasia, Cystic                  |                                  3                          1     1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                                                                     |             
      Mediastinal, Hyperplasia, Lymphoid   |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |    4                       4                                             |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  A  +  A  +  +  A  +  +  +|             
      Hemorrhage                           |                1                                                         |             
      Hyperplasia, Lymphoid                |    4                       4                                             |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular, Histiocyte    | 3  2        2  1     3  2     1  2     2  1  1     1        1     2  2  3|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1              2                          2        2  2  1  2     1   |             
      Infiltration Cellular, Histiocyte    |                1        1  1     1  1                       1            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  A  I  +  A  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3|             
                                           | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                  2     2                                 |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1                                                               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Olfactory Epithelium, Atrophy        | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Degeneration                         |    4                                                                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 3| 2| 3| 3| 3| 3| 8| 3| 2| 3| 3| 2| 1| 3| 3| 0| 3| 3| 3|             
                                           | 9| 9| 3| 9| 9| 0| 8| 9| 0| 0| 0| 0| 1| 0| 9| 0| 8| 9| 7| 0| 0| 3| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |          1              1        1  2        1     1     1           1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2|            |
                                           | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  I  +  +  +  +  M  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +|  38        |
      Cyst                                 |                                                       1                  |      1  1.0|
      Degeneration, Hyaline                | 3                    2                                         3         |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Infiltration Cellular, Histiocyte    |    1                                                              1      |      2  1.0|
      Inflammation, Chronic Active         |                                                       4        1         |      2  2.5|
      Metaplasia, Squamous                 |                                                                2         |      1  2.0|
      Myxomatous Change                    | 1  2              1        2  1  1           1  1        1  1  1  2  1   |     21  1.1|
      Necrosis                             |                                                       4                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |       X                 X              X                             X   |      8     |
      Clear Cell Focus                     |                                                                X         |      1     |
      Eosinophilic Focus                   |                                                                      X   |      7     |
      Fatty Change                         |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                            1                          1                  |      5  1.0|
      Inflammation, Chronic                | 1     2     1  1  1  1  1        1     1  2  1  1  1  1  1  1  1     1  1|     40  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2|            |
                                           | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mineralization                       |                                                                   2      |      1  2.0|
      Tension Lipidosis                    |                                                                          |      1     |
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +  +  +  +     +     +  +  +     +  +  +  +  +     +           +  +|  32        |
      Fat, Necrosis                        | 2     2  3  2  2     2     2  2  2     2  2  3  2  2     2           2  2|     31  2.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                                                               |      1  2.0|
      Infiltration Cellular, Lymphocyte    |    2                                                                     |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |                                                    2                     |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                       2                  |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.0|
      Hypertrophy                          |                                                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2|            |
                                           | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|  37        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Hyperplasia           |       1                                   2     2     1     1        1   |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  I  +  +  +  +|  47        |
      Cyst                                 | 1                          2           2        3                        |      8  2.5|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       3                                                                  |      1  3.0|
      Hydrometra                           |       3  1  3     2     3     3  2     2  3  3  2     4     2     2  2   |     25  2.5|
      Hyperplasia, Cystic                  | 1                    2              2                          2     1   |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                       4                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                       +        +                             +      |   5        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +  M  +  M  +  M|  37        |
      Hyperplasia, Lymphoid                | 2                                                                        |      3  3.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2|            |
                                           | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Infiltration Cellular, Plasma Cell   |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |          4                                                               |      3  4.0|
      Infiltration Cellular, Plasma Cell   |                   4                                                      |      1  4.0|
      Infiltration Cellular, Histiocyte    | 3  1  2     2  2  1  2  2  2  1           2  2  2  2  2  2     2     2  2|     35  1.9|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hematopoietic Cell Proliferation     | 1                 1  1     3                       1  3                  |     15  1.6|
      Infiltration Cellular, Histiocyte    | 1                             1  1        1                          1  1|     12  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                         2              2     1                           |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                          +                  |   2        |
      Degeneration                         |                                                       3                  |      1  3.0|
      Mineralization                       |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 2| 2| 3| 2| 2| 8| 3| 2| 6| 7| 3| 2| 3| 3| 5| 2| 3| 2| 2| 2| 2|            |
                                           | 0| 9| 0| 7| 9| 9| 0| 9| 9| 9| 0| 9| 7| 7| 0| 9| 0| 0| 3| 9| 0| 9| 1| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                      1   |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   1                                                      |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    2                                   2                                 |      2  2.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  2                                       |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infarct                              |                                                       3                  |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Mineralization                       |    1                                                                     |      1  1.0|
      Nephropathy                          | 1  1     1           1     1  1  1  1     1        1  3        1  1  1   |     22  1.1|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3|             
                                           | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Gallbladder                             | A  +  +  A  +  M  +  +  +  +  A  +  +  +  +  +  M  +  +  A  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration, Hyaline                |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Necrosis                             |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                      1     1              1        1        1     1  1   |             
      Inflammation, Chronic Active         |    1  1  1  2  3  3  2     1        1     3     2  1  1     2     3  2  3|             
      Metaplasia, Squamous                 |       2  3  1  2  3  1     2        1     3     3  1  3     1     1      |             
      Myxomatous Change                    |    2  3  2     1     2     2     1  3     2     1  2        1  1  2  2  2|             
      Necrosis                             |          2           2     2        3     2     2           1     3  2  2|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X  X           X           X        X  X              X     X|             
      Clear Cell Focus                     |    X        X  X  X  X  X              X     X  X           X     X      |             
      Eosinophilic Focus                   |             X  X     X  X           X        X                    X      |             
      Fatty Change                         | 1                                      1  2                 1     1      |             
      Hematopoietic Cell Proliferation     |                2                    2     3           1        1         |             
      Inflammation, Chronic                | 2  3        3  1  3  2  2        2  1     1  3  2  2  1     1  1  2     2|             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3|             
                                           | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +           +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Fat, Necrosis                        |    1  2  3  1  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2           2  2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Atrophy                              | 1                                                                        |             
      Basophilic Focus                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            1                                             |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              3                           |             
      Hypertrophy                          | 2  2        3           1  1        2        2                          1|             
      Necrosis                             |                                                                2         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    3                                               1  1                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3|             
                                           | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  I  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  I  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |             2              2                                             |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |             1  3     3  1  3     3  2        1        2           2      |             
      Hyperplasia, Cystic                  |                                        2  3                             2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +     +     +        A                       +              +   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  M  +  +|             
      Infiltration Cellular, Plasma Cell   |                4           3                                             |             
      Infiltration Cellular, Histiocyte    | 1     1           1                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  A  +  +  +  +  +|             
      Hemorrhage                           |                                     2              1                     |             
      Infiltration Cellular, Plasma Cell   |       2        4                                                         |             
      Infiltration Cellular, Histiocyte    | 3  2  2     2     2  1  1  2                 1              3  2  2      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                         2           3     3           2        2  1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3|             
                                           | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1        1     1  1  1  1     1  1  1     1  1  1        1           1|             
      Metaplasia, Osseous                  |                   2                    2                                 |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  A  M  M  +  M  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   1                    2                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +            |             
      Infiltration Cellular, Mast Cell     |                                                             1            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1                                                      |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     1                                    |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            2                                             |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 1| 2| 0| 6| 2| 3| 2| 3| 2| 3| 0| 2| 1| 3| 6| 3| 3| 2| 3| 2| 0| 0| 3| 2| 3|             
                                           | 7| 9| 3| 0| 9| 0| 9| 0| 9| 0| 8| 9| 7| 0| 1| 0| 0| 9| 0| 3| 1| 9| 0| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                         2                                                |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Acute          |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                                4  4                        |             
      Inflammation, Chronic                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Metaplasia, Osseous                  |                                              1                           |             
      Mineralization                       |                            1                                             |             
      Nephropathy                          | 1     1     1  1           1     1  1  1  2  1  1  1  1        4  1  1  1|             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2|            |
                                           | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  A  A  +  +  +  +  +  +  +  +  A  M  +  +  +  +  A  +  +  +  +  +|  38        |
      Cyst                                 |                                     2                                    |      1  2.0|
      Degeneration, Hyaline                |                            4                                             |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Necrosis                             |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Infiltration Cellular, Histiocyte    |                1                                                  1  1   |     10  1.0|
      Inflammation, Chronic Active         | 1  3  2  1     2  2              2        2     2  3        3  2  3  3  4|     32  2.1|
      Metaplasia, Squamous                 | 1  4  1  4     1  2              1        2     1  2                 4  2|     26  2.0|
      Myxomatous Change                    | 2     2     1  1  3  1  1  1        1     2  2  2  2  1        2         |     31  1.7|
      Necrosis                             | 2     1  1     1  4              2        2     1  3        3  2  2  1  3|     24  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  43        |
      Ulcer                                |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  42        |
      Inflammation, Acute                  |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  42        |
      Infiltration Cellular, Mixed Cell    |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |       X        X                                X                    X   |     12     |
      Clear Cell Focus                     |       X                 X  X  X           X  X     X  X        X     X   |     21     |
      Eosinophilic Focus                   |       X  X     X           X              X  X                 X  X      |     15     |
      Fatty Change                         | 2     1     2     4                       2        1                 1   |     12  1.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2|            |
                                           | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hematopoietic Cell Proliferation     |          4  1                                                            |      7  2.0|
      Inflammation, Chronic                | 1  1           2  1     1  1  3  2  1  1  1  2  2  2  2     1  1  2  3  2|     38  1.7|
      Centrilobular, Degeneration          |             2                                                            |      1  2.0|
      Centrilobular, Necrosis              |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Thrombosis                           |             3                                                            |      1  3.0|
      Fat, Necrosis                        |          2  2  2  2  2  2  2        2  2  2  2  2  2  2  2  2  2  3  2  2|     41  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Atrophy                              |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                   X      |      1     |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
      Mineralization                       |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Hyperplasia                          |    1                                                                     |      2  2.0|
      Hypertrophy                          |                      2                       1        1                 2|     12  1.7|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2|            |
                                           | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  A  +  +  +  M  +|  40        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |       2  2           2     1                 1        2           2  3   |     11  1.8|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  M  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M  +  I  +  +  +|  35        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Angiectasis                          |                         2                             4                  |      2  3.0|
      Cyst                                 |    2                          2     3                       2     2      |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     4                                    |      1  4.0|
      Hydrometra                           |       2  4  1  2     2                    1  3              2     1     3|     20  2.1|
      Hyperplasia, Cystic                  |    2                    2     2  2              3  2                 3   |     10  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |             +  +     +                    +                    +         |  10        |
      Pancreatic, Hyperplasia, Lymphoid    |                4                                                         |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2|            |
                                           | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  M  +  +  +  M  M  +  +  +  M  +  +  M  +  +  +  +  +|  39        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  45        |
      Hemorrhage                           |             3                                                            |      3  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.0|
      Infiltration Cellular, Histiocyte    | 2  3  2  3           2  2  3              2     1           1     2  2  2|     25  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Congestion                           |                                                 2                        |      1  2.0|
      Hematopoietic Cell Proliferation     |       1  3  4     2           1  2  2  3  1  1              2        2   |     18  2.1|
      Infiltration Cellular, Histiocyte    |             1     1  1  1  1        1     1  1  1  1              1  1  1|     28  1.0|
      Metaplasia, Osseous                  |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  M  M  +  +  A  M  +  +  +  +|  36        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       2                 2                                   2            |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Inflammation, Chronic      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2|            |
                                           | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Thrombosis                           |          1                                                               |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                2                                                         |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                             1            |      2  1.5|
      Olfactory Epithelium, Atrophy        |    2                                                                     |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                               +              +                           |   2        |
      Cornea, Inflammation, Acute          |                                              4                           |      1  4.0|
      Cornea, Inflammation, Chronic        |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                               2                                          |      4  2.8|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Infarct                              |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 0| 8| 3| 7| 3| 2| 3| 3| 3| 2| 9| 2| 2| 3| 3| 2| 4| 2| 3| 2| 2| 2|            |
                                           | 2| 9| 9| 1| 3| 0| 9| 0| 9| 0| 0| 0| 9| 8| 9| 9| 0| 0| 9| 5| 9| 0| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Metaplasia, Osseous                  |                      1                                               1   |      3  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          |                                  1  2  1  1  1  1  1           1  1     1|     27  1.2|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3|             
                                           | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                          3               |             
      Inflammation, Chronic Active         |                                                          2               |             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  M  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                                              3                           |             
      Inflammation, Chronic Active         |                                                          2               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X                    X                                   X        X|             
      Clear Cell Focus                     | X                          X  X              X     X  X     X     X     X|             
      Eosinophilic Focus                   |    X        X     X     X  X     X                    X     X     X      |             
      Fatty Change                         |    1                       2                       1     1  1        1   |             
      Inflammation, Chronic                |    1        1                 1     1  1                                1|             
      Mineralization                       |                                                          2               |             
      Necrosis                             |                                                          3               |             
      Tension Lipidosis                    |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +              +     +                                +           +   |             
      Mineralization                       |                                                          2               |             
      Fat, Necrosis                        |    2              2     2                                3           3   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3|             
                                           | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                  3              1        2              2|             
      Inflammation, Acute                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +     +        +  +  +  +  +     +        +        +        +  +  +  +|             
      Inflammation, Chronic Active         |                      3                                3                  |             
      Malformation                         | 3  1     1        2  2  2  1  2     2        1                 X  2  1  3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            1                                             |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2                                                           2   |             
      Hypertrophy                          | 3        2  1  1  2  1  3  4  2     2        2  2     2     2     1  2  1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3|             
                                           | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                           3                              |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  M  +  M  M  +  +  +  +  M  M  +  M  +  +  +  M  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                2                                         3               |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  2     2  3                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 4| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 9| 3| 3| 7| 3| 4| 3| 3| 3|             
                                           | 1| 1| 0| 0| 1| 0| 1| 0| 1| 1| 1| 6| 0| 1| 0| 0| 0| 1| 0| 7| 1| 6| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                    3        1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         2|             
      Polyp, Inflammatory                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                2                                                         |             
      Metaplasia, Osseous                  |                            2                                             |             
      Mineralization                       |                                                          1               |             
      Nephropathy                          | 1  2     2  1  1     1  1  1     2  1  1  3  1     1  2  3  1  1  1  2  1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3|            |
                                           | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  M  M  +  +  +  +|  40        |
      Degeneration, Hyaline                |                               2                                         4|      3  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X     X     X  X     X           X  X                 X            |     14     |
      Clear Cell Focus                     | X  X  X  X  X     X  X  X  X  X        X        X                        |     21     |
      Eosinophilic Focus                   | X  X                                         X  X                        |     13     |
      Fatty Change                         |             1        1     1                                             |      9  1.1|
      Inflammation, Chronic                |                         1              1        1  1           2         |     11  1.1|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             | 1                                                                        |      2  2.0|
      Tension Lipidosis                    |                                                          X           X   |      2     |
      Vacuolization Cytoplasmic, Focal     |                                                          2               |      1  2.0|
      Bile Duct, Cyst                      |                                                          1               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +  +           +        +     +                                       |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3|            |
                                           | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
      Fat, Necrosis                        |    2  2           2        2     2                                       |     10  2.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |                                     3                    1               |      6  2.0|
      Inflammation, Acute                  |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +  +     +  +  +  +  +  +           +  +  +  +  +  +  +        +  +   |  33        |
      Inflammation, Chronic Active         | 3                 3                             2                    1   |      6  2.5|
      Malformation                         |    2  2     1  1  1  2  1  3           1  2  1     1  4  3        1      |     29  1.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1                 1                                                |      3  1.0|
      Mineralization                       |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                       2                                       |      5  1.8|
      Hypertrophy                          |    2  3     2     2     1  1              2  1        1              1   |     27  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|  44        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3|            |
                                           | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                   +      |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                  4              3                        |      3  3.3|
      Inflammation, Chronic Active         |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  +  M  M  M  M  +  +  +  M  M  M  +  +  +  M  M  +  M|  28        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3|            |
                                           | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Angiectasis                          |    1                                                                     |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2     2                          2  2           2           2  1         |     10  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  M  +  M  M  +  M  +  +  M|  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                              3                           |      3  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                     3                 3  2     1         |      5  2.2|
      Polyp, Inflammatory                  |                                                       3                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 0| 3| 2| 3| 3| 3| 3|            |
                                           | 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 4| 0| 9| 0| 1| 0| 1| 0| 2| 2| 0| 0| 1| 1| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          | 4  1  1  2  1  3  2  1  1     2     3     1  1  3  1  2  1  4  1  1  1  3|     43  1.6|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3|             
                                           | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  A  +  +|             
      Cyst                                 | 1                                                                        |             
      Degeneration, Hyaline                |                                                                4         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Mineralization                       |                                     3                                    |             
      Necrosis                             |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X  X  X     X                             X                 X   |             
      Clear Cell Focus                     | X  X     X  X        X     X  X  X     X  X        X  X  X     X     X  X|             
      Eosinophilic Focus                   | X              X           X     X     X  X        X                    X|             
      Fatty Change                         |    1     1  1              1                       1                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                                  1        1  1  1  1                 1   |             
      Necrosis                             |                                     4                                    |             
      Tension Lipidosis                    |                                                                          |             
      Centrilobular, Degeneration          |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +  +        +                                                   |             
      Fat, Necrosis                        |          2  2        3                                                   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3|             
                                           | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Artery, Inflammation                 |                                              4                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +     +  +  +  +     +  +        +  +     +           +   |             
      Inflammation, Chronic Active         |                                        2        2                        |             
      Malformation                         | 1  2  1  1     1     2  1  2  1     1  2           2     2           1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Angiectasis                          |                                                                          |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1  2|             
      Hypertrophy                          | 1  2  1        1     1  1  2  1  1  1  1  1  1     2        2  1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3|             
                                           | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Chronic Active         |                   2              2                                       |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  +  M  +  M  +  M  M  M  +  M  +  M  +  M  M  M  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Infiltration Cellular, Histiocyte    |             2     1        1           1           1        1        1   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   1                 3           1                 2      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  M  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3|             
                                           | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               1                       3              2  2|             
      Mediastinum, Inflammation, Acute     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                   2              1                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Cornea, Inflammation, Chronic        |                3                                                         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                           |             
      Hyperplasia                          |                               3                                          |             
      Inflammation, Acute                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 0| 3| 4| 3| 3|             
                                           | 0| 0| 0| 1| 1| 1| 1| 1| 0| 0| 0| 0| 8| 0| 0| 1| 1| 1| 1| 0| 8| 1| 6| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    56 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |       2                          2                    3                  |             
      Inflammation, Suppurative            |                                     3                 3                  |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          | 1  1  1     1  1  1  1  2     1  2     1  2  1  3  2     2  2  1     1  2|             
      Papilla, Necrosis                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3|            |
                                           | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  M  +  I  +  +  +  +  M  +  M  +  I  +  I  A  M  +  A  +|  38        |
      Cyst                                 |                                                                          |      1  1.0|
      Degeneration, Hyaline                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  47        |
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                X     X              X                             X      |     10     |
      Clear Cell Focus                     |                   X     X              X  X           X  X     X         |     23     |
      Eosinophilic Focus                   |             X     X                 X                                    |     11     |
      Fatty Change                         |             1                    1        1           1  1     1  2      |     12  1.1|
      Hematopoietic Cell Proliferation     |                                                                   1      |      1  1.0|
      Inflammation, Chronic                | 1     1     1  1  1                 1        1     2                    1|     15  1.1|
      Necrosis                             | 2                                                                        |      2  3.0|
      Tension Lipidosis                    |             X        X                                                   |      2     |
      Centrilobular, Degeneration          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3|            |
                                           | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                    3                     |      1  3.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                        4                                 |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +     +  +     +  +     +  +  +           +     +     +        +|  27        |
      Inflammation, Chronic Active         |                2  2     2                          3                     |      6  2.2|
      Malformation                         |          3                 2     2  1  2                 2     1        1|     22  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                          +               |   1        |
      Angiectasis                          |                                                          3               |      1  3.0|
      Thrombosis                           |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2        2           2        1              2        2            |      8  1.8|
      Hypertrophy                          | 1        2        1  1                 1  1  1  4     2        1        2|     27  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    3        2            |      3  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3|            |
                                           | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M|  42        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              | 2                    2                    3                              |      3  2.3|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                             4            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                      4                                                   |      1  4.0|
      Inflammation, Suppurative            |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3|            |
                                           | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                 +                        |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  M|  29        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Infiltration Cellular, Histiocyte    |          1              1              2  1        2  1        1     2   |     15  1.3|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                        1           1              2  1   |      8  1.5|
      Infiltration Cellular, Histiocyte    |                                                                      1   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  I  M  +  M|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                 +      |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 7| 7| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 5| 3| 3| 8| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 1| 0| 3|            |
                                           | 1| 1| 1| 1| 5| 0| 0| 8| 1| 0| 8| 1| 1| 0| 0| 0| 0| 1| 0| 0| 7| 0| 1| 8| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    56 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Hemorrhage                           |                                                                2         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                              2     2           2         |      7  2.0|
      Mediastinum, Inflammation, Acute     |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Olfactory Epithelium, Atrophy        | 2        2                          3                                    |      3  2.3|
      Olfactory Epithelium, Metaplasia     |                                                                         2|      3  1.7|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Acute                  |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                             2            |      3  2.7|
      Metaplasia, Osseous                  |                                           1                              |      1  1.0|
      Nephropathy                          | 2     1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1     1     2  2|     41  1.3|
      Papilla, Necrosis                    |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Transitional Epithelium, Hyperplasia |                                                          3               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3|             
                                           | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  M|             
      Cyst                                 |                                                                      1   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X        X        X                     |             
      Clear Cell Focus                     |                X  X     X           X  X  X  X     X              X  X   |             
      Eosinophilic Focus                   |                                        X  X        X           X         |             
      Fatty Change                         |          1              1           1        1                           |             
      Hematopoietic Cell Proliferation     |                                                                1         |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                | 1  1           1        1              1                 1  1     1  1  1|             
      Necrosis                             |          1                                                     1         |             
      Tension Lipidosis                    |                               X                          X               |             
      Centrilobular, Degeneration          |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +  +     +  +                 +  +  +  +  +     +                     |             
      Fat, Necrosis                        |    2  2     2  2                 2  2  2  2  2     2                     |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3|             
                                           | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                1                                                         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +     +  +  +     +     +  +  +  +  +  +           +           +   |             
      Inflammation, Chronic Active         |                   2              2                                       |             
      Malformation                         | 1  2  1     1  2  1     2     1     1  1  1  2           3           3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2        3  2              2                 2                 3   |             
      Hypertrophy                          | 1  1  1  1  2           2     1        2  2     1        1           1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  M  +  +  +  M  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                   1                                1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3|             
                                           | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2                                                                       2|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                     3                                3   |             
      Inflammation, Chronic Active         |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |       2                                                                  |             
      Infiltration Cellular, Histiocyte    |    2  1  3  2  2     2  3        2  2  2  2     3        2  1  3  3  2  2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3|             
                                           | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2           1     2                    2     2     1  4  2     1|             
      Infiltration Cellular, Histiocyte    |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  M  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         2              1                 2  2  1        2|             
      Glands, Degeneration, Hyaline        |                                              4                           |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Hyperplasia    |                                                          2               |             
      Olfactory Epithelium, Metaplasia     |                               1                                          |             
      Sinus, Inflammation, Chronic Active  |                      3                                                   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3|             
                                           | 1| 1| 1| 8| 1| 1| 1| 3| 0| 1| 1| 0| 0| 0| 0| 0| 1| 1| 2| 1| 1| 1| 1| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    168                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cornea, Inflammation, Chronic        |                                           2                              |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Hyperplasia                          |       2                                                                  |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2  3                                      2                              |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                      2   |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 2  1  1  2  2  1  1  2  1  3  1  1  1  2  2  1  1  1     1  3  2  2  1  2|             
      Renal Tubule, Hyperplasia            |                                           1                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                          2               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2|            |
                                           | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  M  +  M  +  +  M  A  +  A  +  +  +  +  +  +  +  +  I  A  +|  39        |
      Cyst                                 |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                    1                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             |                                              1                           |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute                  |                                  4                                       |      1  4.0|
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  M  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                           X                       X      |      5     |
      Clear Cell Focus                     |                         X  X  X     X           X  X  X  X     X         |     19     |
      Eosinophilic Focus                   |          X                          X           X  X     X               |      9     |
      Fatty Change                         | 1     1                       1                                1         |      8  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infarct                              |                                                                         2|      1  2.0|
      Inflammation, Chronic                | 1        2     1  1        1  1        1  1           1  1     1  1     1|     23  1.0|
      Necrosis                             |                                                                          |      2  1.0|
      Tension Lipidosis                    |                                                                          |      2     |
      Centrilobular, Degeneration          |                                  2     1                    3            |      3  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2|            |
                                           | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |       +        +           +  +  +  +              +     +     +     +   |  20        |
      Fat, Necrosis                        |       2        2           2  3  2  2              2     2     2         |     19  2.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                    4                     |      1  4.0|
      Cyst                                 |                                                    4                     |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                              1                           |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Necrosis                             |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +  +        +        +  +  +  +  +     +  +  +  +     +  +  +         |  30        |
      Inflammation, Chronic Active         |                         2  3                                3            |      5  2.4|
      Malformation                         |    2  1        1        1     2  1  1     1  2  1  3     1     1         |     27  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |          1                                                               |      1  1.0|
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
      Mineralization                       |                                                       1                  |      1  1.0|
      Artery, Inflammation, Chronic Active |                         3              2                                 |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         2                                      2         |      8  2.3|
      Hypertrophy                          |    2        1     1        3  2  1  1           2  2  1  1               |     23  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2|            |
                                           | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +  M  +  +  M  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  37        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |                                     2                                    |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |       2           3                          3                           |      5  2.4|
      Inflammation, Chronic Active         |          2                                         3                     |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                 2  3  3                  |      5  2.8|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Germinal Epithelium, Degeneration    |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2|            |
                                           | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  +  +  M  +  +  M  M  M  +  +  M  +  +  +  +  +  +  +  M  M|  30        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Angiectasis                          |                                     2                       2           3|      3  2.3|
      Hematopoietic Cell Proliferation     |                                                    3                     |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2     1  2  2  2        2     2     2     2  2  3  2  3  2     2  2      |     34  2.1|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2                    2                                2     2        2  2|     15  1.9|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  M|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2|            |
                                           | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                   1      |      1  1.0|
      Inflammation, Chronic Active         |             1                                                            |      1  1.0|
      Thrombosis                           |                                              2                           |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                           2     2              3     2   |      4  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                 1                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                  1           1  1                 1  1   |     11  1.4|
      Glands, Degeneration, Hyaline        |                                                                          |      1  4.0|
      Olfactory Epithelium, Atrophy        |                                                    2                     |      1  2.0|
      Olfactory Epithelium, Hyperplasia    |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
      Sinus, Inflammation, Chronic Active  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   2        |
      Cornea, Inflammation, Chronic        |                                                                   1      |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                         1                                               3|      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      3  2.3|
      Hydronephrosis                       |                   3                                                      |      1  3.0|
      Infarct                              |                                     2  2  2                              |      4  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 8| 3| 9| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2|            |
                                           | 5| 1| 0| 1| 0| 0| 0| 1| 0| 0| 1| 0| 0| 7| 0| 3| 1| 1| 0| 1| 0| 0| 1| 0| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    168                                    | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Inflammation, Suppurative            | 3                                      2     2                           |      3  2.3|
      Nephropathy                          |    2  1  3  1  1  2  2  1  2  2  1  2     1  1  1  2  2  1  4  1  1  2  2|     47  1.6|
      Renal Tubule, Hyperplasia            |                            2                                             |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | A  +  M  A  A  +  A  A  A  A  +  +  M  +  +  +  +  +  +  +  A  +  I  +  +|             
      Degeneration, Hyaline                |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  A  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                      1                 1              1                  |             
      Inflammation, Chronic Active         |                            1                       2  3                 1|             
      Metaplasia, Squamous                 |                            3                       1  1                  |             
      Myxomatous Change                    |                      1                    1     1  1              1  2   |             
      Necrosis                             |                                                    1  2                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  A  +  A  +  A  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  A  +  A  +  A  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  A  +  +  +  A  A  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  A  +  A  +  A  A  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                                   X           X  X                  |             
      Clear Cell Focus                     |    X  X        X              X                    X  X           X      |             
      Eosinophilic Focus                   | X                                      X              X        X     X   |             
      Fatty Change                         |    1  1                                1  1  1                 1  1  1  1|             
      Inflammation, Chronic                |    1  1        1     2        1        1  1  1     1  1  1  1  2  1     1|             
      Necrosis                             |             2        2  2                                   3            |             
      Centrilobular, Degeneration          |          2              2           2                       2            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +  +        +                                   +           +         |             
      Fat, Necrosis                        |    2  2        2                                   2           2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       2                          1                                       |             
      Inflammation, Acute                  |       2                                                                  |             
      Ulcer                                |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                         2                                                |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +              +     +        +     +           +     +        +|             
      Inflammation, Chronic Active         |                                                          2               |             
      Malformation                         |          2              1     1        1     1           1     1        2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1                                                                  |             
      Mineralization                       |                      2     1                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3     2        2           3  2     2           2               |             
      Hypertrophy                          |    2        2        1                 1     2        2        3  2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  M  +  +  M  +  +  +  +  I  +  +  +  +  +  +  I  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2                                                                        |             
      Infiltration Cellular, Histiocyte    |    3                                                                     |             
      Inflammation, Chronic Active         |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             4            |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  M  M  +  +  +  +  +  M  +  M  +  M  M  M  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  A  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  3        2     1     2  3  3     2  2  1  1  2  3  1  2  2  1  2  3|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  1                 2  2           3           2                 3  1   |             
      Infiltration Cellular, Mast Cell     |                                     3                                    |             
      Infiltration Cellular, Histiocyte    |    1  1        1  1                    1  1  1  1  1     1     1        1|             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  M  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 7| 0| 6| 6| 6| 7| 4| 6| 7| 5| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 2| 5| 3| 1| 4| 5| 1| 3| 8| 2| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 0| 1| 7| 1| 7| 6| 8| 7| 0| 3| 6| 0| 6| 1| 0| 1| 1| 0| 9| 0| 0| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    504                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Mineralization                       |                         1                                                |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                            3                                             |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    1                     |             
      Olfactory Epithelium, Metaplasia     |                1                                                         |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                                          |             
      Hydronephrosis                       |                      2                                                   |             
      Infiltration Cellular, Mast Cell     |                                                                         1|             
      Inflammation, Suppurative            |                                                             2            |             
      Nephropathy                          | 1  1  2  1     1     2  2  2  2        1  1  1  2  2  2  1     1  3  2  2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8|            |
                                           | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | A  M  M  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  34        |
      Degeneration, Hyaline                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  44        |
      Infiltration Cellular, Histiocyte    |                   1                                                  1  1|      6  1.0|
      Inflammation, Chronic Active         |       3                          2                                   2  2|      8  2.0|
      Metaplasia, Squamous                 |       2                          1                                       |      5  1.6|
      Myxomatous Change                    |                1  2              2                 1     1           2  2|     13  1.4|
      Necrosis                             |       2                                                              2  3|      5  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  39        |
      Inflammation, Chronic Active         |                                                    2                    2|      2  2.0|
      Necrosis                             |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  40        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  38        |
      Hyperplasia, Lymphoid                |                4                                                         |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  38        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                X              X        X           X     X        X      |     10     |
      Clear Cell Focus                     |             X  X           X  X        X           X        X        X   |     15     |
      Eosinophilic Focus                   |          X  X           X              X     X  X        X               |     12     |
      Fatty Change                         |    2                 1        1                                      1   |     13  1.1|
      Inflammation, Chronic                |    2  1     3  1  1  1  1  1  1  1     2        1  1  1  3  3     1  1   |     33  1.3|
      Necrosis                             |                                     1                                    |      5  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8|            |
                                           | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Centrilobular, Degeneration          |                                                                          |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                               +     +  +           +     +               |  10        |
      Fat, Necrosis                        |                               2     2  2           2     2               |     10  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                              2                           |      3  1.7|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +     +  +              +  +  +     +        +  +  +  +  +  +  +  +   |  23        |
      Inflammation, Chronic Active         |                               1  2                    2  3     2         |      6  2.0|
      Malformation                         |    1     1  1              1  1        1        1  1     1  1     1  1   |     20  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8|            |
                                           | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          2     2           2                       2  3              3   |     13  2.3|
      Hypertrophy                          |    2        4                 1        1        2        1        3      |     15  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +|  40        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |                      2                                         1         |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                     3           3                        |      3  2.7|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                               2  2                                       |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |       2                                         2                        |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8|            |
                                           | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Degeneration    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                 +                        |   1        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                 1                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  M  +  M  M  +  +  M  M  +  M  +  +  +  +  +  M  M  M  +  +  +|  30        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  M  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  41        |
      Infiltration Cellular, Histiocyte    |    3  2     2  2     2  2  2  2  2     1           3  2  2  2  1  3  2  3|     37  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition                   |                   3                                                      |      1  3.0|
      Hematopoietic Cell Proliferation     |       2  3              1        2  1                 1  1               |     15  1.8|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |             1        1  1  1  1                       1     1  1  1  1  1|     23  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  M  +  M  M  +  M|  33        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8|            |
                                           | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                         1                       1                    2   |      4  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                          1               |      2  2.0|
      Mediastinum, Hemorrhage              |                                           3                              |      1  3.0|
      Mediastinum, Inflammation, Acute     |                                           3                              |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |                                                                1         |      2  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |       +                                                                  |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 88122-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                              ELMIRON                                          Date: 04/23/01    
Route: GAVAGE                                                                                                     Time: 15:23:02    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 9| 3| 6| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8|            |
                                           | 2| 0| 8| 1| 0| 1| 8| 1| 0| 0| 1| 1| 1| 1| 1| 5| 0| 1| 0| 0| 1| 0| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    504                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nephropathy                          | 1  1  1  1  1     1  1  2  1  1  4     1        1  1  3  2  1  2  1  2  2|     41  1.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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