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TDMS Study 88124-02 Pathology Tables

NTP Experiment-Test: 88124-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:05:30

                                                  FINAL#2,  13 WEEK SUBCHRONIC




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  01/24/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88124-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:05:30  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Accidently Killed                                                                                      1                        
    Natural Death                                                                                          2                        
    Moribund Sacrifice                                                                                     1           10           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10            6                        

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                (10)         (10)         
      Inflammation, Focal                              3 (30%)                                                                      
   Salivary Glands                                    (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration                                                                                         3 (30%)      9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                                                                                    1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration                                                                                         8 (80%)     10 (100%)    
   Thyroid Gland                                      (10)                                                (10)         (9)          
      Inflammation                                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (9)          (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                              9 (90%)      9 (90%)     
      Cyst                                                                                                              1 (10%)     
   Uterus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                              4 (40%)      8 (80%)     
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:05:30  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (9)          (10)         (10)         (10)         (8)          (10)         
      Hyperplasia                                                  10 (100%)    10 (100%)    10 (100%)     6 (75%)      8 (80%)     
      Pigmentation                                                 10 (100%)    10 (100%)    10 (100%)     8 (100%)     9 (90%)     
   Lymph Node, Mesenteric                             (10)                                                (9)          (9)          
      Hyperplasia                                                                                                       1 (11%)     
   Lymph Node, Mediastinal                                         (2)          (3)          (1)          (4)          (6)          
      Hyperplasia                                                   1 (50%)      1 (33%)                   3 (75%)      1 (17%)     
      Pigmentation                                                                                         3 (75%)      3 (50%)     
   Spleen                                             (10)         (10)         (10)         (10)         (9)          (10)         
      Hematopoietic Cell Proliferation                 1 (10%)      3 (30%)      3 (30%)                   6 (67%)      5 (50%)     
   Thymus                                             (10)         (10)         (10)         (10)         (9)          (9)          
      Atrophy                                                                                              3 (33%)      9 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (10)         (10)         (10)         (10)         (10)         (10)         
      Fat, Atrophy                                                                                         3 (30%)     10 (100%)    
   Skin                                               (10)         (1)                                    (10)         (10)         
      Subcutaneous Tissue, Hemorrhage                                                                      1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)                                                (10)         (10)         
      Hemorrhage                                                                                           1 (10%)                  
      Necrosis, Focal                                                                                      1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                               1 (10%)      5 (50%)      4 (40%)      6 (60%)     
      Inflammation, Suppurative                        1 (10%)                                             1 (10%)      6 (60%)     
      Necrosis                                         1 (10%)                                             3 (30%)      5 (50%)     
      Epiglottis, Metaplasia, Squamous                                                        4 (40%)      5 (50%)      5 (50%)     
      Squamous Epithelium, Hyperplasia                                           1 (10%)      4 (40%)      7 (70%)     10 (100%)    
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Inflammation, Chronic Active                                 10 (100%)    10 (100%)    10 (100%)     9 (90%)     10 (100%)    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:05:30  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                             10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Interstitium, Fibrosis                                       10 (100%)    10 (100%)    10 (100%)     9 (90%)     10 (100%)    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                                            2 (20%)      3 (30%)     10 (100%)    
   Trachea                                            (10)         (10)         (9)          (10)         (10)         (10)         
      Foreign Body                                                               1 (11%)      6 (60%)      1 (10%)      5 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Infarct                                                                                              1 (10%)                  
      Nephropathy                                      1 (10%)                                                                      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:05:30  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                     1            9           
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10            9                        

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                   (1)          (10)         (10)         
      Inflammation, Focal                                                                                               1 (10%)     
      Necrosis, Focal                                  1 (10%)                                1 (100%)     1 (10%)                  
   Stomach, Forestomach                               (10)                                                (10)         (10)         
      Ulcer                                                                                                             1 (10%)     
      Epithelium, Hyperplasia                                                                                           1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                                                                       1 (10%)      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                (10)         (10)         
      Hypertrophy                                      1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                                                                                  (1)          (2)          
      Congestion                                                                                                        1 (50%)     
      Inflammation                                                                                         1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:05:30  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                                                                       2 (20%)     
   Lymph Node, Bronchial                              (8)          (10)         (10)         (10)         (10)         (7)          
      Hyperplasia                                                  10 (100%)    10 (100%)    10 (100%)     8 (80%)      7 (100%)    
      Pigmentation                                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)     7 (100%)    
   Lymph Node, Mediastinal                            (4)          (6)          (1)          (3)          (5)          (6)          
      Hyperplasia                                                   1 (17%)                   1 (33%)      2 (40%)      3 (50%)     
      Pigmentation                                                  2 (33%)                   1 (33%)      2 (40%)      4 (67%)     
   Spleen                                             (10)         (10)         (10)         (9)          (9)          (10)         
      Hematopoietic Cell Proliferation                              5 (50%)      3 (30%)      3 (33%)      6 (67%)      9 (90%)     
   Thymus                                             (10)         (9)          (10)         (10)         (7)          (7)          
      Atrophy                                                                                              1 (14%)      7 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                  2 (20%)      2 (20%)      6 (60%)      6 (60%)      4 (40%)     
      Inflammation, Suppurative                        1 (10%)      3 (30%)                   1 (10%)      5 (50%)      4 (40%)     
      Necrosis                                         2 (20%)      4 (40%)      1 (10%)      2 (20%)      3 (30%)      4 (40%)     
      Epiglottis, Metaplasia, Squamous                 1 (10%)                                9 (90%)      8 (80%)      9 (90%)     
      Respiratory Epithelium, Degeneration, Hyaline    1 (10%)                                                                      
      Squamous Epithelium, Hyperplasia                                                        3 (30%)      9 (90%)      8 (80%)     
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Inflammation, Chronic Active                                 10 (100%)    10 (100%)    10 (100%)     9 (90%)     10 (100%)    
      Alveolar Epithelium, Hyperplasia                             10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Interstitium, Fibrosis                                       10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                                            2 (20%)      1 (10%)      9 (90%)     

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:05:30  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation                                                                                                      1 (10%)     
      Inflammation, Suppurative                                                  1 (10%)                                            
   Trachea                                            (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                               2 (20%)      3 (30%)      3 (30%)      3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                      (1)                       (10)         (10)         
      Infarct                                                                                                           1 (10%)     
      Nephropathy                                      2 (20%)                                                          1 (10%)     
   Urinary Bladder                                    (10)                                                (10)         (10)         
      Inflammation, Chronic                            1 (10%)                                                                      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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