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TDMS Study 88124-03 Pathology Tables

NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:48:11

                                                          14 WEEK SSAC




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  09/25/98

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:48:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     


  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (3)          (2)          (10)                                   
      Hematopoietic Cell Proliferation                                                        2 (20%)                               
      Hepatodiaphragmatic Nodule                                    1 (33%)      1 (50%)      1 (10%)                               
      Inflammation, Granulomatous                      2 (20%)                                3 (30%)                               
   Mesentery                                          (1)                                                                           
      Fat, Inflammation, Chronic                       1 (100%)                                                                     
   Stomach, Glandular                                 (10)                                   (10)                                   
      Mineralization                                   2 (20%)                                1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                   (10)                                   
      Cardiomyopathy                                   2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:48:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (4)          (8)          (8)          (6)                                    
      Foreign Body                                                  5 (63%)      7 (88%)      4 (67%)                               
      Hyperplasia                                                   1 (13%)      6 (75%)      3 (50%)                               
   Lymph Node, Mediastinal                            (7)          (9)          (8)          (9)                                    
      Foreign Body                                                  6 (67%)      6 (75%)      5 (56%)                               
      Hyperplasia                                                   4 (44%)      3 (38%)      5 (56%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Foreign Body                                                  8 (80%)     10 (100%)    10 (100%)                              
      Inflammation, Chronic Active                     2 (20%)     10 (100%)    10 (100%)    10 (100%)                              
      Alveolar Epithelium, Hyperplasia                              5 (50%)      1 (10%)      7 (70%)                               
      Alveolus, Proteinosis                                         9 (90%)     10 (100%)    10 (100%)                              
   Nose                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Suppurative                                                  2 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                   (10)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:48:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy                                      1 (10%)                                                                      
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:48:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     


  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Mesentery                                                                    (1)                                                 
      Fat, Necrosis                                                              1 (100%)                                           
   Stomach, Glandular                                 (10)                                   (10)                                   
      Mineralization                                   4 (40%)                                4 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                   (10)                                   
      Cardiomyopathy                                   4 (40%)                                2 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)                                   (10)                                   
      C-Cell, Hyperplasia                                                                     1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (10)                      (1)          (10)                                   
      Atrophy                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (10)         (6)          (10)         (9)                                    
      Foreign Body                                                  4 (67%)      2 (20%)      7 (78%)                               
      Hyperplasia                                                   1 (17%)      2 (20%)      5 (56%)                               
   Lymph Node, Mediastinal                            (10)         (5)          (9)          (9)                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:48:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Foreign Body                                                  3 (60%)      7 (78%)      7 (78%)                               
      Hyperplasia                                                   1 (20%)      6 (67%)      7 (78%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Acute                                           2 (20%)                                                         
   Lung                                               (10)         (10)         (10)         (10)                                   
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)                              
      Inflammation, Chronic Active                     1 (10%)     10 (100%)    10 (100%)    10 (100%)                              
      Alveolar Epithelium, Hyperplasia                              7 (70%)     10 (100%)    10 (100%)                              
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)                              
   Nose                                               (10)         (10)         (10)         (10)                                   
      Olfactory Epithelium, Atrophy                                                           1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                   (10)                                   
      Nephropathy                                      3 (30%)                                3 (30%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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