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TDMS Study 88124-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99       
EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 13:55:40       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            14 WEEK SSAC                                                            
                                                                                                                                    

               REASONS FOR REMOVAL:    25017 Scheduled Sacrifice                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99     
EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 13:55:40     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 INDIUM PHOSPHIDE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Lung                                   Foreign Body
                                       Inflammation Chronic
Lung: Alveolar Epithelium              Hyperplasia
Lung: Alveolus                         Proteinosis
Lymph Node, Bronchial                  Foreign Body
                                       Hyperplasia
Lymph Node, Mediastinal                Foreign Body
                                       Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Liver                                  Hematopoietic Cell Proliferation
Lung                                   Foreign Body
                                       Inflammation Chronic
Lung: Alveolar Epithelium              Hyperplasia
Lung: Alveolus                         Proteinosis
Lymph Node, Bronchial                  Foreign Body
                                       Hyperplasia
Lymph Node, Mediastinal                Foreign Body
                                       Hyperplasia
===============================================================
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/10 (40%)   0/0 (0%)     0/0 (0%)     2/10 (20%)  |2/10 (20%)   0/0 (0%)     0/0 (0%)     0/10 (0%)    |
|POLY-3 ADJUSTED (b)|     99.9%        0.0%         0.0%         99.7%       |99.7%        0.0%         0.0%         0.0%         |
|INT SACRIFICE 1 (c)|     4/10 (40%)   0/0 (0%)     0/0 (0%)     2/10 (20%)  |2/10 (20%)   0/0 (0%)     0/0 (0%)     0/10 (0%)    |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     91 (I)       ---          ---          91 (I)      |92 (I)       ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.263N     P=1.000N     P=1.000N     P=0.317N    |P=0.166N     P=1.000N     P=1.000N     P=0.234N     |
|POLY 3             |     (e)          (e)          (e)          P=0.202N    |(e)          (e)          (e)          P=0.067N     |
|POLY 1.5           |     (e)          (e)          (e)          P=0.205N    |(e)          (e)          (e)          P=0.070N     |
|POLY 6             |     (e)          (e)          (e)          P=0.202N    |(e)          (e)          (e)          P=0.067N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.258N     P=1.000      P=1.000      P=0.314N    |P=0.160N     P=1.000      P=1.000      P=0.237N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/10 (30%)   0/0 (0%)     0/0 (0%)     3/10 (30%)  |1/10 (10%)   0/0 (0%)     0/0 (0%)     0/10 (0%)    |
|POLY-3 ADJUSTED (b)|     99.8%        0.0%         0.0%         99.8%       |99.3%        0.0%         0.0%         0.0%         |
|INT SACRIFICE 1 (c)|     3/10 (30%)   0/0 (0%)     0/0 (0%)     3/10 (30%)  |1/10 (10%)   0/0 (0%)     0/0 (0%)     0/10 (0%)    |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     91 (I)       ---          ---          91 (I)      |92 (I)       ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.624      P=1.000N     P=1.000N     P=0.683     |P=0.369N     P=1.000N     P=1.000N     P=0.500N     |
|POLY 3             |     (e)          (e)          (e)          P=0.555     |(e)          (e)          (e)          P=0.159N     |
|POLY 1.5           |     (e)          (e)          (e)          P=0.559     |(e)          (e)          (e)          P=0.167N     |
|POLY 6             |     (e)          (e)          (e)          P=0.555     |(e)          (e)          (e)          P=0.159N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.628      P=1.000      P=1.000      P=0.686N    |P=0.366N     P=1.000      P=1.000      P=0.500N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    2/10 (20%)   0/10 (0%)    0/10 (0%)   |0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         99.7%        0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|INT SACRIFICE 1 (c)|     0/10 (0%)    2/10 (20%)   0/10 (0%)    0/10 (0%)   |0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.368N     P=0.234      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.160N     P=0.067      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.164N     P=0.070      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.160N     P=0.067      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.366N     P=0.237      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    0/2 (0%)     0/0 (0%)     0/10 (0%)   |0/10 (0%)    0/3 (0%)     0/2 (0%)     2/10 (20%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         99.7%        |
|INT SACRIFICE 1 (c)|     0/10 (0%)    0/2 (0%)     0/0 (0%)     0/10 (0%)   |0/10 (0%)    0/3 (0%)     0/2 (0%)     2/10 (20%)   |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.111      (e)          (e)          P=0.234      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.067      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.070      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.067      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.106      (e)          (e)          P=0.237      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    0/2 (0%)     0/0 (0%)     0/10 (0%)   |2/10 (20%)   0/3 (0%)     0/2 (0%)     3/10 (30%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |99.7%        0.0%         0.0%         99.8%        |
|INT SACRIFICE 1 (c)|     0/10 (0%)    0/2 (0%)     0/0 (0%)     0/10 (0%)   |2/10 (20%)   0/3 (0%)     0/2 (0%)     3/10 (30%)   |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |92 (I)       ---          ---          92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.310      P=0.527N     P=0.630N     P=0.500      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.226      P=0.213N     P=0.260N     P=0.352      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.225      P=0.220N     P=0.268N     P=0.356      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.226      P=0.213N     P=0.259N     P=0.352      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.306      P=0.577N     P=0.682N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%)    8/10 (80%)   10/10 (100%) 10/10 (100%) |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       100.0%       100.0%      |0.0%         100.0%       100.0%       100.0%       |
|INT SACRIFICE 1 (c)|     0/10 (0%)    10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%)    8/10 (80%)   10/10 (100%) 10/10 (100%) |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       91 (I)       91 (I)      |---          92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=1.000N     P=1.000N     |
|POLY 1.5           |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=1.000N     P=1.000N     |
|POLY 6             |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=1.000N     P=1.000N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/10 (10%)   10/10 (100%) 10/10 (100%) 10/10 (100%)|2/10 (20%)   10/10 (100%) 10/10 (100%) 10/10 (100%) |
|POLY-3 ADJUSTED (b)|     99.3%        100.0%       100.0%       100.0%      |99.7%        100.0%       100.0%       100.0%       |
|INT SACRIFICE 1 (c)|     1/10 (10%)   10/10 (100%) 10/10 (100%) 10/10 (100%)|2/10 (20%)   10/10 (100%) 10/10 (100%) 10/10 (100%) |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     91 (I)       91 (I)       91 (I)       91 (I)      |92 (I)       92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.003 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.006 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.002 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.005 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    7/10 (70%)   10/10 (100%) 10/10 (100%)|0/10 (0%)    5/10 (50%)   1/10 (10%)   7/10 (70%)   |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       100.0%       100.0%      |0.0%         99.9%        99.3%        100.0%       |
|INT SACRIFICE 1 (c)|     0/10 (0%)    7/10 (70%)   10/10 (100%) 10/10 (100%)|0/10 (0%)    5/10 (50%)   1/10 (10%)   7/10 (70%)   |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       91 (I)       91 (I)      |---          92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P=0.008 **   P=0.022 *    P=0.500      P=0.003 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=0.159      P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=0.167      P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=0.159      P<0.001 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P=0.007 **   P=0.016 *    P=0.500      P=0.002 **   |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Proteinosis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%)    9/10 (90%)   10/10 (100%) 10/10 (100%) |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       100.0%       100.0%      |0.0%         100.0%       100.0%       100.0%       |
|INT SACRIFICE 1 (c)|     0/10 (0%)    10/10 (100%) 10/10 (100%) 10/10 (100%)|0/10 (0%)    9/10 (90%)   10/10 (100%) 10/10 (100%) |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       91 (I)       91 (I)      |---          92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=1.000N     P=1.000N     |
|POLY 1.5           |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=1.000N     P=1.000N     |
|POLY 6             |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P<0.001 **   P<0.001 **   P=1.000N     P=1.000N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    4/6 (67%)    2/10 (20%)   7/9 (78%)   |0/4 (0%)     5/8 (63%)    7/8 (88%)    4/6 (67%)    |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       99.7%        100.0%      |0.0%         100.0%       100.0%       100.0%       |
|INT SACRIFICE 1 (c)|     0/10 (0%)    4/6 (66.7%)  2/10 (20%)   7/9 (77.8%) |0/4 (0%)     5/8 (62.5%)  7/8 (87.5%)  4/6 (66.7%)  |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       91 (I)       91 (I)      |---          92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.005 **   P=0.010 *    P=0.234      P=0.002 **  |P=0.234      P=0.083      P=0.015 *    P=0.085      |
|POLY 3             |     P<0.001 **   P<0.001 **   P=0.067      P<0.001 **  |P=0.169      P=0.009 **   P<0.001 **   P=0.006 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P=0.070      P<0.001 **  |P=0.169      P=0.010 *    P<0.001 **   P=0.006 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P=0.067      P<0.001 **  |P=0.168      P=0.009 **   P<0.001 **   P=0.006 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.005 **   P=0.008 **   P=0.237      P<0.001 **  |P=0.230      P=0.071      P=0.010 *    P=0.071      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    1/6 (17%)    2/10 (20%)   5/9 (56%)   |0/4 (0%)     1/8 (13%)    6/8 (75%)    3/6 (50%)    |
|POLY-3 ADJUSTED (b)|     0.0%         99.6%        99.7%        99.9%       |0.0%         99.5%        100.0%       99.9%        |
|INT SACRIFICE 1 (c)|     0/10 (0%)    1/6 (16.7%)  2/10 (20%)   5/9 (55.6%) |0/4 (0%)     1/8 (12.5%)  6/8 (75%)    3/6 (50%)    |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       91 (I)       91 (I)      |---          92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.006 **   P=0.398      P=0.234      P=0.015 *   |P=0.113      P=0.638      P=0.039 *    P=0.175      |
|POLY 3             |     P<0.001 **   P=0.093      P=0.067      P<0.001 **  |P=0.053      P=0.245      P<0.001 **   P=0.037 *    |
|POLY 1.5           |     P<0.001 **   P=0.099      P=0.070      P<0.001 **  |P=0.054      P=0.255      P<0.001 **   P=0.039 *    |
|POLY 6             |     P<0.001 **   P=0.093      P=0.067      P<0.001 **  |P=0.053      P=0.245      P<0.001 **   P=0.037 *    |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.006 **   P=0.375      P=0.237      P=0.011 *   |P=0.109      P=0.667      P=0.030 *    P=0.167      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    3/5 (60%)    7/9 (78%)    7/9 (78%)   |0/7 (0%)     6/9 (67%)    6/8 (75%)    5/9 (56%)    |
|POLY-3 ADJUSTED (b)|     0.0%         99.9%        100.0%       100.0%      |0.0%         100.0%       100.0%       99.9%        |
|INT SACRIFICE 1 (c)|     0/10 (0%)    3/5 (60%)    7/9 (77.8%)  7/9 (77.8%) |0/7 (0%)     6/9 (66.7%)  6/8 (75%)    5/9 (55.6%)  |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       91 (I)       91 (I)      |---          92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.007 **   P=0.024 *    P=0.002 **   P=0.002 **  |P=0.246      P=0.016 *    P=0.009 **   P=0.038 *    |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.178      P<0.001 **   P<0.001 **   P=0.003 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.179      P<0.001 **   P<0.001 **   P=0.003 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.178      P<0.001 **   P<0.001 **   P=0.003 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.007 **   P=0.022 *    P<0.001 **   P<0.001 **  |P=0.243      P=0.010 *    P=0.006 **   P=0.029 *    |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    1/5 (20%)    6/9 (67%)    7/9 (78%)   |0/7 (0%)     4/9 (44%)    3/8 (38%)    5/9 (56%)    |
|POLY-3 ADJUSTED (b)|     0.0%         99.7%        100.0%       100.0%      |0.0%         99.9%        99.9%        99.9%        |
|INT SACRIFICE 1 (c)|     0/10 (0%)    1/5 (20%)    6/9 (66.7%)  7/9 (77.8%) |0/7 (0%)     4/9 (44.4%)  3/8 (37.5%)  5/9 (55.6%)  |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          91 (I)       91 (I)       91 (I)      |---          92 (I)       92 (I)       92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.362      P=0.005 **   P=0.002 **  |P=0.089      P=0.079      P=0.130      P=0.038 *    |
|POLY 3             |     P<0.001 **   P=0.071      P<0.001 **   P<0.001 **  |P=0.058      P=0.013 *    P=0.028 *    P=0.003 **   |
|POLY 1.5           |     P<0.001 **   P=0.076      P<0.001 **   P<0.001 **  |P=0.059      P=0.014 *    P=0.030 *    P=0.003 **   |
|POLY 6             |     P<0.001 **   P=0.071      P<0.001 **   P<0.001 **  |P=0.058      P=0.013 *    P=0.028 *    P=0.003 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.333      P=0.003 **   P<0.001 **  |P=0.086      P=0.069      P=0.123      P=0.029 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)   |0/10 (0%)    0/10 (0%)    2/10 (20%)   0/10 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         99.7%        0.0%         |
|INT SACRIFICE 1 (c)|     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)   |0/10 (0%)    0/10 (0%)    2/10 (20%)   0/10 (0%)    |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          92 (I)       ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.699N     (e)          P=0.234      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.462N     (e)          P=0.067      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.469N     (e)          P=0.070      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.462N     (e)          P=0.067      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.701N     (e)          P=0.237      (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 143 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/10 (40%)   0/0 (0%)     0/0 (0%)     4/10 (40%)  |2/10 (20%)   0/0 (0%)     0/0 (0%)     1/10 (10%)   |
|POLY-3 ADJUSTED (b)|     99.9%        0.0%         0.0%         99.9%       |99.7%        0.0%         0.0%         99.3%        |
|INT SACRIFICE 1 (c)|     4/10 (40%)   0/0 (0%)     0/0 (0%)     4/10 (40%)  |2/10 (20%)   0/0 (0%)     0/0 (0%)     1/10 (10%)   |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     91 (I)       ---          ---          91 (I)      |92 (I)       ---          ---          92 (I)       |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.617      P=1.000N     P=1.000N     P=0.672     |P=0.419N     P=1.000N     P=1.000N     P=0.500N     |
|POLY 3             |     (e)          (e)          (e)          P=0.569     |(e)          (e)          (e)          P=0.299N     |
|POLY 1.5           |     (e)          (e)          (e)          P=0.572     |(e)          (e)          (e)          P=0.305N     |
|POLY 6             |     (e)          (e)          (e)          P=0.569     |(e)          (e)          (e)          P=0.299N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.620      P=1.000      P=1.000      P=0.675N    |P=0.417N     P=1.000      P=1.000      P=0.500N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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