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https://ntp.niehs.nih.gov/go/4497

TDMS Study 88124-03 Pathology Tables

NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33

                                                    FINAL#1 CORE STUDY RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  09/25/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           14           14           12                                     
    Natural Death                                      3            4                         4                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           30           36           34                                     
    Moribund Sacrifice                                              1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (49)         (50)         (46)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   2 (4%)       1 (2%)       1 (2%)                                
      Basophilic Focus                                46 (92%)     39 (78%)     47 (94%)     44 (88%)                               
      Clear Cell Focus                                17 (34%)      8 (16%)     17 (34%)      9 (18%)                               
      Eosinophilic Focus                               2 (4%)       5 (10%)      3 (6%)       5 (10%)                               
      Fatty Change                                     4 (8%)       2 (4%)       4 (8%)       3 (6%)                                
      Hepatodiaphragmatic Nodule                       7 (14%)      4 (8%)       2 (4%)      11 (22%)                               
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)       2 (4%)                    1 (2%)                                
      Mixed Cell Focus                                 6 (12%)                   4 (8%)       4 (8%)                                
      Necrosis                                                      3 (6%)                    3 (6%)                                
      Regeneration                                     1 (2%)       2 (4%)                    4 (8%)                                
      Tension Lipidosis                                                                       1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Vacuolization Cytoplasmic, Focal                 4 (8%)       1 (2%)                    1 (2%)                                
      Bile Duct, Hyperplasia                           4 (8%)       8 (16%)      4 (8%)      10 (20%)                               
      Centrilobular, Necrosis                          3 (6%)       7 (14%)      3 (6%)       9 (18%)                               
      Periportal, Infiltration Cellular,                                                                                            
          Mononuclear Cell                                                       1 (2%)                                             
      Serosa, Hemorrhage                                                         1 (2%)                                             
   Mesentery                                          (9)          (15)         (15)         (19)                                   
      Fat, Necrosis                                    9 (100%)    15 (100%)    15 (100%)    18 (95%)                               
   Oral Mucosa                                                     (2)                       (2)                                    
      Pharyngeal, Hyperplasia                                       1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Atrophy                                          5 (10%)     12 (24%)      6 (12%)      8 (16%)                               
      Basophilic Focus                                 1 (2%)                    3 (6%)       1 (2%)                                
      Metaplasia, Hepatocyte                                                                  1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          3 (6%)                    1 (2%)       2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Basophilic Focus                                 3 (6%)                                 2 (4%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Hyperplasia, Squamous                            2 (4%)       1 (2%)                    2 (4%)                                
      Inflammation, Acute                                           1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Ulcer                                            1 (2%)       2 (4%)                    1 (2%)                                
   Stomach, Glandular                                 (49)         (50)         (50)         (48)                                   
      Necrosis                                         1 (2%)       5 (10%)      1 (2%)       2 (4%)                                
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Hyperplasia, Squamous                            1 (100%)     1 (100%)                  1 (100%)                              
   Tooth                                              (2)                                                                           
      Inflammation, Chronic Active                     2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  37 (74%)     29 (58%)     41 (82%)     30 (60%)                               
      Atrium, Thrombosis                                            1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (50)         (49)                                   
      Atrophy                                                                                 2 (4%)                                
      Degeneration, Cystic                             3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
      Hyperplasia                                     21 (43%)     23 (47%)     27 (54%)     25 (51%)                               
      Hypertrophy                                     11 (22%)     13 (27%)      3 (6%)       6 (12%)                               
      Necrosis                                                      4 (8%)                    3 (6%)                                
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)                    1 (2%)       4 (8%)                                
   Adrenal Medulla                                    (50)         (48)         (50)         (49)                                   
      Hyperplasia                                      6 (12%)     13 (27%)      9 (18%)     15 (31%)                               
      Necrosis                                                                                1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (48)         (49)                                   
      Cyst                                             1 (2%)                                 2 (4%)                                
      Hemorrhage, Chronic                                                                     1 (2%)                                
      Pars Distalis, Angiectasis                       1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Pars Distalis, Hyperplasia                      15 (30%)     15 (30%)     13 (27%)     17 (35%)                               
   Thyroid Gland                                      (47)         (47)         (50)         (47)                                   
      C-Cell, Hyperplasia                             41 (87%)     42 (89%)     42 (84%)     39 (83%)                               
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (47)         (47)         (49)                                   
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      5 (10%)      1 (2%)       2 (4%)       4 (8%)                                
   Ovary                                              (50)         (50)         (50)         (49)                                   
      Cyst                                             9 (18%)      6 (12%)      7 (14%)      3 (6%)                                
      Inflammation, Granulomatous                      2 (4%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (49)                                   
      Cyst                                                                       1 (2%)       1 (2%)                                
      Inflammation, Acute                                                        1 (2%)       1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Cervix, Hypertrophy                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (48)                                   
      Atrophy                                                                    1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                 1 (2%)                                
      Myelofibrosis                                    1 (2%)                                 1 (2%)                                
   Lymph Node, Bronchial                              (25)         (30)         (35)         (30)                                   
      Foreign Body                                                 23 (77%)     26 (74%)     20 (67%)                               
   Lymph Node, Mandibular                             (43)         (48)         (42)         (42)                                   
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Lymph Node, Mediastinal                            (28)         (36)         (39)         (26)                                   
      Foreign Body                                                 15 (42%)     18 (46%)     13 (50%)                               
   Spleen                                             (50)         (50)         (50)         (47)                                   
      Fibrosis                                                      1 (2%)       1 (2%)       4 (9%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       3 (6%)       6 (12%)      2 (4%)                                
      Hemorrhage                                       1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Metaplasia, Osseous                                                        1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Thymus                                             (45)         (47)         (50)         (45)                                   
      Atrophy                                                       1 (2%)                                                          
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                      2 (4%)       4 (8%)       1 (2%)       5 (10%)                               
      Hyperplasia                                                                             1 (2%)                                
   Skin                                               (50)         (49)         (50)         (49)                                   
      Foreign Body                                                                            1 (2%)                                
      Hyperkeratosis                                                2 (4%)                                                          
      Inflammation, Acute                                           1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (49)                                   
      Osteopetrosis                                    6 (12%)      7 (14%)      6 (12%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (50)         (49)                                   
      Inflammation, Acute                                           1 (2%)                    1 (2%)                                
      Epiglottis, Metaplasia, Squamous                 3 (6%)       2 (4%)       1 (2%)                                             
      Respiratory Epithelium, Metaplasia, Squamous     4 (8%)       5 (10%)      4 (8%)       6 (12%)                               
   Lung                                               (50)         (50)         (50)         (50)                                   
      Cyst, Squamous                                                1 (2%)       1 (2%)      10 (20%)                               
      Foreign Body                                     1 (2%)      49 (98%)     50 (100%)    50 (100%)                              
      Hyperplasia, Atypical                                         8 (16%)      8 (16%)     39 (78%)                               
      Inflammation, Chronic Active                    10 (20%)     49 (98%)     50 (100%)    49 (98%)                               
      Metaplasia, Squamous                                          2 (4%)       1 (2%)       4 (8%)                                
      Thrombosis                                       2 (4%)                                                                       
      Alveolar Epithelium, Hyperplasia                 8 (16%)     15 (30%)     22 (44%)     16 (32%)                               
      Alveolar Epithelium, Metaplasia                              46 (92%)     47 (94%)     48 (96%)                               
      Alveolus, Infiltration Cellular, Histiocyte     16 (32%)      1 (2%)                                                          
      Alveolus, Proteinosis                                        49 (98%)     47 (94%)     50 (100%)                              
      Bronchiole, Inflammation, Suppurative            1 (2%)                                                                       
      Interstitium, Fibrosis                                       48 (96%)     50 (100%)    49 (98%)                               
      Mediastinum, Inflammation, Chronic                            1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                        6 (12%)      8 (16%)      3 (6%)       9 (18%)                               
      Thrombosis                                       2 (4%)       3 (6%)       1 (2%)       6 (12%)                               
      Glands, Hyperplasia                                                                     1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Lateral Wall, Metaplasia, Squamous                            2 (4%)                                                          
      Olfactory Epithelium, Metaplasia                 1 (2%)       4 (8%)       1 (2%)       1 (2%)                                
      Respiratory Epithelium, Hyperplasia              2 (4%)       4 (8%)       1 (2%)       7 (14%)                               
      Respiratory Epithelium, Metaplasia, Squamous                  3 (6%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (3)          (3)                                    
      Cataract                                         1 (100%)                  3 (100%)     3 (100%)                              
      Retina, Atrophy                                  1 (100%)                  3 (100%)     3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (48)                                   
      Accumulation, Hyaline Droplet                                 1 (2%)                                                          
      Infarct                                                                                 1 (2%)                                
      Nephropathy                                     41 (82%)     38 (78%)     42 (84%)     38 (79%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           18           16           15                                     
    Natural Death                                      3            3            5            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           29           29           26                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (50)         (46)         (46)                                   
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Duodenum                          (49)         (50)         (47)         (48)                                   
      Necrosis                                                                                1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       2 (4%)                    2 (4%)                                
      Basophilic Focus                                29 (58%)     29 (58%)     31 (62%)     34 (68%)                               
      Clear Cell Focus                                18 (36%)     16 (32%)     22 (44%)     16 (32%)                               
      Degeneration, Cystic                             3 (6%)       9 (18%)      5 (10%)      5 (10%)                               
      Eosinophilic Focus                               3 (6%)       3 (6%)       4 (8%)       3 (6%)                                
      Fatty Change                                     5 (10%)      5 (10%)      7 (14%)      3 (6%)                                
      Hepatodiaphragmatic Nodule                       3 (6%)       4 (8%)       2 (4%)       9 (18%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Granulomatous                      1 (2%)                                 1 (2%)                                
      Mixed Cell Focus                                 1 (2%)                                 2 (4%)                                
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Regeneration                                                               3 (6%)                                             
      Vacuolization Cytoplasmic, Focal                                           1 (2%)                                             
      Bile Duct, Hyperplasia                          39 (78%)     42 (84%)     40 (80%)     36 (72%)                               
      Centrilobular, Necrosis                          5 (10%)      4 (8%)       6 (12%)     10 (20%)                               
      Serosa, Fibrosis                                                           1 (2%)                                             
      Serosa, Hemorrhage                                                         1 (2%)                                             
   Mesentery                                          (6)          (6)          (6)          (8)                                    
      Artery, Inflammation, Chronic Active                                                    1 (13%)                               
      Artery, Mineralization                                                                  1 (13%)                               
      Fat, Metaplasia, Osseous                                                   1 (17%)                                            
      Fat, Necrosis                                    6 (100%)     6 (100%)     6 (100%)     6 (75%)                               
   Oral Mucosa                                        (1)                       (3)          (2)                                    
      Gingival, Abscess                                                                       1 (50%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                         14 (28%)     16 (32%)     17 (34%)     19 (38%)                               
      Basophilic Focus                                 3 (6%)       3 (6%)       3 (6%)                                             
      Hyperplasia                                      2 (4%)       2 (4%)       4 (8%)       2 (4%)                                
      Thrombosis                                       1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Hyperplasia                                                          1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)       3 (6%)                    2 (4%)                                
      Basophilic Focus                                 2 (4%)                                 1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Duct, Metaplasia, Squamous                       1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Diverticulum                                     2 (4%)                                                                       
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Hyperplasia, Squamous                            1 (2%)       1 (2%)       3 (6%)       2 (4%)                                
      Inflammation, Acute                              1 (2%)                    3 (6%)                                             
      Necrosis                                                                   1 (2%)                                             
      Ulcer                                            1 (2%)                    4 (8%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (48)         (49)                                   
      Mineralization                                   1 (2%)       1 (2%)       2 (4%)       3 (6%)                                
      Necrosis                                         2 (4%)                    2 (4%)                                             
   Tongue                                             (2)                                                                           
      Hyperplasia, Squamous                            2 (100%)                                                                     
   Tooth                                              (2)                       (3)          (1)                                    
      Developmental Malformation                                                 1 (33%)                                            
      Inflammation, Chronic Active                     2 (100%)                  2 (67%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Necrosis, Fibrinoid                              1 (100%)                                                                     
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  44 (88%)     43 (86%)     43 (86%)     46 (92%)                               
      Necrosis                                                                                1 (2%)                                
      Artery, Mineralization                                                     1 (2%)       1 (2%)                                
      Atrium, Thrombosis                               2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
      Epicardium, Fibrosis                                                       1 (2%)                                             
      Mesothelium, Hyperplasia                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Atrophy                                                       2 (4%)                    1 (2%)                                
      Degeneration, Cystic                             1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                     32 (64%)     27 (54%)     33 (66%)     33 (66%)                               
      Hypertrophy                                      7 (14%)      5 (10%)      3 (6%)       9 (18%)                               
      Necrosis                                         2 (4%)       2 (4%)       2 (4%)       4 (8%)                                
      Vacuolization Cytoplasmic                                     1 (2%)       1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                     26 (52%)     26 (52%)     24 (49%)     32 (64%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                    1 (2%)                    1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      4 (8%)       3 (6%)       3 (6%)       1 (2%)                                
   Parathyroid Gland                                  (44)         (44)         (45)         (45)                                   
      Hyperplasia                                                   1 (2%)                                                          
      Hypertrophy                                                   1 (2%)                                                          
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Pars Distalis, Angiectasis                                    2 (4%)                                                          
      Pars Distalis, Hyperplasia                       5 (10%)     13 (26%)     12 (24%)     15 (30%)                               
      Pars Intermedia, Angiectasis                     1 (2%)                                                                       
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (49)         (49)         (48)         (48)                                   
      C-Cell, Hyperplasia                             41 (84%)     31 (63%)     42 (88%)     37 (77%)                               
      Follicular Cell, Hyperplasia                                  2 (4%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                                                                     (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                                                       2 (4%)       1 (2%)                                
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)       2 (4%)       2 (4%)       4 (8%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     14 (28%)     13 (26%)     13 (26%)      9 (18%)                               
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       3 (6%)       3 (6%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          8 (16%)      4 (8%)       5 (10%)     10 (20%)                               
      Necrosis                                                      1 (2%)                                                          
      Artery, Inflammation, Chronic Active             2 (4%)       1 (2%)                    2 (4%)                                
      Germinal Epithelium, Degeneration                                          1 (2%)                                             
      Interstitial Cell, Hyperplasia                   6 (12%)      7 (14%)      6 (12%)      9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Hyperplasia, Reticulum Cell                      1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
   Lymph Node                                         (2)          (4)                       (2)                                    
      Ectasia                                          1 (50%)                                                                      
   Lymph Node, Bronchial                              (26)         (27)         (41)         (44)                                   
      Foreign Body                                                 19 (70%)     27 (66%)     36 (82%)                               
      Hyperplasia                                                                             1 (2%)                                
   Lymph Node, Mandibular                             (44)         (42)         (47)         (47)                                   
      Infiltration Cellular, Plasma Cell                                         1 (2%)       1 (2%)                                
   Lymph Node, Mediastinal                            (25)         (19)         (45)         (40)                                   
      Foreign Body                                                  8 (42%)     27 (60%)     15 (38%)                               
      Hyperplasia                                                                             1 (3%)                                
   Spleen                                             (50)         (50)         (49)         (48)                                   
      Angiectasis                                                                1 (2%)                                             
      Fibrosis                                         8 (16%)     15 (30%)      9 (18%)     11 (23%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                    1 (2%)                                
      Hemorrhage                                       2 (4%)                    2 (4%)       1 (2%)                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                         2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
   Thymus                                             (47)         (47)         (46)         (45)                                   
      Cyst                                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (24)         (33)         (31)         (24)                                   
      Galactocele                                      7 (29%)      4 (12%)      4 (13%)      5 (21%)                               
      Inflammation, Chronic                                                      1 (3%)                                             
   Skin                                               (50)         (50)         (50)         (49)                                   
      Cyst Epithelial Inclusion                                     1 (2%)       2 (4%)                                             
      Hyperkeratosis                                                                          3 (6%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     4 (8%)                                 4 (8%)                                
      Necrosis                                                                   1 (2%)                                             
      Epidermis, Hyperplasia                           1 (2%)                                                                       
      Prepuce, Inflammation, Chronic Active            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                                         1 (2%)                    2 (4%)                                
      Inflammation, Acute                              2 (4%)       3 (6%)       5 (10%)      3 (6%)                                
      Epiglottis, Metaplasia, Squamous                              2 (4%)       1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                           1 (2%)                                                          
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (50)                                   
      Cyst, Squamous                                                1 (2%)       3 (6%)       2 (4%)                                
      Foreign Body                                     1 (2%)      50 (100%)    50 (100%)    50 (100%)                              
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Atypical                                        16 (32%)     23 (46%)     39 (78%)                               
      Inflammation, Chronic Active                     5 (10%)     50 (100%)    50 (100%)    50 (100%)                              
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Metaplasia, Squamous                                          1 (2%)       3 (6%)       4 (8%)                                
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                11 (22%)     20 (40%)     21 (42%)     31 (62%)                               
      Alveolar Epithelium, Metaplasia                              45 (90%)     45 (90%)     48 (96%)                               
      Alveolus, Infiltration Cellular, Histiocyte      8 (16%)                                                                      
      Alveolus, Proteinosis                                        50 (100%)    48 (96%)     47 (94%)                               
      Artery, Mediastinum, Mineralization                                        1 (2%)                                             
      Interstitium, Fibrosis                                       49 (98%)     50 (100%)    50 (100%)                              
      Mediastinum, Thrombosis                                                    1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        9 (18%)     10 (20%)      8 (16%)      8 (16%)                               
      Thrombosis                                       4 (8%)       4 (8%)       6 (12%)      8 (16%)                               
      Glands, Hyperplasia                                                                     1 (2%)                                
      Lateral Wall, Metaplasia, Squamous                                         1 (2%)                                             
      Olfactory Epithelium, Atrophy                    1 (2%)       2 (4%)       1 (2%)                                             
      Olfactory Epithelium, Metaplasia                 6 (12%)      2 (4%)       2 (4%)       7 (14%)                               
      Respiratory Epithelium, Hyperplasia              5 (10%)      7 (14%)      4 (8%)       5 (10%)                               
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Respiratory Epithelium, Necrosis                                                        1 (2%)                                
   Trachea                                            (50)         (50)         (49)         (49)                                   
      Inflammation, Suppurative                        1 (2%)       3 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:55:33  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (1)          (1)                                    
      Cataract                                         1 (100%)                  1 (100%)     1 (100%)                              
      Retina, Atrophy                                  1 (100%)                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                                           1 (2%)                                
      Hydronephrosis                                                             2 (4%)                                             
      Infarct                                                       1 (2%)       2 (4%)       1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Nephropathy                                     47 (94%)     46 (92%)     43 (86%)     46 (92%)                               
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Hemorrhage                                                                 2 (4%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

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