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TDMS Study 88124-03 Pathology Tables

NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46

                                                    FINAL#1 CORE STUDY RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  09/25/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           14           14           12                                     
    Natural Death                                      3            4                         4                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           30           36           34                                     
    Moribund Sacrifice                                              1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (48)         (50)         (48)                                   
      Polyp Adenomatous                                             1 (2%)                    1 (2%)                                
   Intestine Large, Rectum                            (49)         (48)         (50)         (47)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Ileum                             (47)         (46)         (50)         (48)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                                                  1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Mesentery                                          (9)          (15)         (15)         (19)                                   
   Oral Mucosa                                                     (2)                       (2)                                    
      Gingival, Squamous Cell Carcinoma                                                       1 (50%)                               
      Pharyngeal, Squamous Cell Carcinoma                                                     1 (50%)                               
      Pharyngeal, Squamous Cell Papilloma                           1 (50%)                                                         
   Pancreas                                           (50)         (50)         (50)         (49)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
   Stomach, Glandular                                 (49)         (50)         (50)         (48)                                   
      Carcinoid Tumor Benign                                                                  1 (2%)                                
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Benign                                             1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (50)         (49)                                   
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (48)         (50)         (49)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                          2 (4%)       6 (13%)      2 (4%)       7 (14%)                               
      Bilateral, Pheochromocytoma Benign                                                      2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (48)         (49)                                   
      Pars Distalis, Adenoma                          30 (60%)     27 (54%)     29 (60%)     25 (51%)                               
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (47)         (47)         (50)         (47)                                   
      Bilateral, C-Cell, Adenoma                                                 1 (2%)       1 (2%)                                
      C-Cell, Adenoma                                  6 (13%)      6 (13%)      5 (10%)      1 (2%)                                
      C-Cell, Carcinoma                                3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (47)         (47)         (49)                                   
      Adenoma                                          5 (10%)      4 (9%)       4 (9%)       6 (12%)                               
      Carcinoma                                                     1 (2%)       3 (6%)                                             
      Carcinoma, Multiple                                           1 (2%)                                                          
      Bilateral, Carcinoma                                          1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (49)                                   
      Granulosa Cell Tumor Malignant                                1 (2%)       1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                    1 (2%)                                             
      Granulosa-Theca Tumor Malignant                  1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (49)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                   10 (20%)      4 (8%)      10 (20%)      8 (16%)                               
      Polyp Stromal, Multiple                                                                 2 (4%)                                
      Sarcoma Stromal                                               1 (2%)                                                          
      Schwannoma Malignant                                          1 (2%)                                                          
   Vagina                                             (1)                                                                           
      Leiomyosarcoma                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (48)                                   
   Lymph Node                                         (1)          (5)          (1)          (2)                                    
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                          1 (100%)                                           
   Lymph Node, Bronchial                              (25)         (30)         (35)         (30)                                   
   Lymph Node, Mandibular                             (43)         (48)         (42)         (42)                                   
   Lymph Node, Mesenteric                             (50)         (47)         (50)         (47)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node, Mediastinal                            (28)         (36)         (39)         (26)                                   
   Spleen                                             (50)         (50)         (50)         (47)                                   
   Thymus                                             (45)         (47)         (50)         (45)                                   
      Thymoma Benign                                                1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     8 (16%)      3 (6%)       1 (2%)                                
      Carcinoma, Multiple                                                                     1 (2%)                                
      Fibroadenoma                                    16 (32%)     14 (28%)     16 (32%)     11 (22%)                               
      Fibroadenoma, Multiple                           4 (8%)       5 (10%)      2 (4%)       1 (2%)                                
   Skin                                               (50)         (49)         (50)         (49)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Keratoacanthoma                                                            2 (4%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Sebaceous Gland, Carcinoma                       1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     3 (6%)                    1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Rhabdomyosarcoma                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (50)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  6 (12%)      4 (8%)      18 (36%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)       1 (2%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                    7 (14%)                               
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Trachea                                            (50)         (49)         (50)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (48)                                   
      Lipoma                                           1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (49)         (49)         (50)         (49)                                   
      Transitional Epithelium, Papilloma                                         1 (2%)       1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            14 (28%)     21 (42%)     14 (28%)     24 (48%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          47          48          46                                       
     Total Primary Neoplasms                          107         120         111         133                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          39          44          40                                       
     Total Benign Neoplasms                            80          78          83          90                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          30          24          32                                       
     Total Malignant Neoplasms                         27          42          28          43                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       2                                                   
     Total Metastatic Neoplasm                          1                       5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           18           16           15                                     
    Natural Death                                      3            3            5            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           29           29           26                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Intestine Large, Colon                             (50)         (50)         (47)         (48)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Cecum                             (48)         (50)         (46)         (46)                                   
   Intestine Small, Duodenum                          (49)         (50)         (47)         (48)                                   
   Intestine Small, Jejunum                           (48)         (48)         (46)         (43)                                   
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (47)         (49)         (46)         (44)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                            1 (2%)                    1 (2%)                                
      Cholangioma                                                   1 (2%)                                                          
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Mesentery                                          (6)          (6)          (6)          (8)                                    
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (13%)                               
   Oral Mucosa                                        (1)                       (3)          (2)                                    
      Gingival, Squamous Cell Papilloma                                          2 (67%)                                            
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                  1 (33%)      1 (50%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (48)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Schwannoma Benign                                1 (2%)                                 1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
      Pericardium, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Pheochromocytoma Malignant                                    3 (6%)       3 (6%)       1 (2%)                                
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                         10 (20%)     16 (32%)     12 (24%)     18 (36%)                               
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
      Bilateral, Pheochromocytoma Benign                            6 (12%)      4 (8%)       5 (10%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
      Carcinoma                                        2 (4%)                    4 (8%)       3 (6%)                                
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
   Parathyroid Gland                                  (44)         (44)         (45)         (45)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          36 (73%)     33 (66%)     31 (62%)     30 (60%)                               
      Pars Distalis, Carcinoma                         1 (2%)       1 (2%)                                                          
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (49)         (49)         (48)         (48)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  5 (10%)      7 (14%)      4 (8%)       9 (19%)                               
      C-Cell, Carcinoma                                1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)                                                              
      Histiocytic Sarcoma                                           1 (100%)                                                        
   Tissue NOS                                                                                (1)                                    
      Chemodectoma Malignant                                                                  1 (100%)                              
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Carcinoma                                        2 (4%)                    1 (2%)                                             
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Adenoma, Multiple                                                          1 (2%)                                             
   Seminal Vesicle                                    (50)         (49)         (48)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           27 (54%)     25 (50%)     26 (52%)     17 (34%)                               
      Interstitial Cell, Adenoma                      13 (26%)     10 (20%)     15 (30%)     16 (32%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
   Lymph Node                                         (2)          (4)                       (2)                                    
      Renal, Squamous Cell Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (50%)                               
   Lymph Node, Bronchial                              (26)         (27)         (41)         (44)                                   
      Histiocytic Sarcoma                                           1 (4%)                                                          
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
   Lymph Node, Mandibular                             (44)         (42)         (47)         (47)                                   
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
   Lymph Node, Mediastinal                            (25)         (19)         (45)         (40)                                   
      Squamous Cell Carcinoma, Metastatic, Lung                                               2 (5%)                                
   Spleen                                             (50)         (50)         (49)         (48)                                   
   Thymus                                             (47)         (47)         (46)         (45)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (24)         (33)         (31)         (24)                                   
      Carcinoma                                                                  1 (3%)       1 (4%)                                
      Fibroadenoma                                     2 (8%)       1 (3%)                    1 (4%)                                
   Skin                                               (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Keratoacanthoma                                  2 (4%)       3 (6%)       5 (10%)      2 (4%)                                
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Trichoepithelioma                                                          1 (2%)                                             
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Sebaceous Gland, Adenoma                         1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       4 (8%)       7 (14%)      3 (6%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Subcutaneous Tissue, Liposarcoma                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Osteoma                                                                    1 (2%)                                             
      Osteosarcoma                                     3 (6%)                    1 (2%)       1 (2%)                                
   Skeletal Muscle                                                              (1)                                                 
      Rhabdomyosarcoma                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Glioma Benign                                                 1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)      8 (16%)     19 (38%)     18 (36%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       5 (10%)      8 (16%)     12 (24%)                               
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       8 (16%)      7 (14%)     11 (22%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple                      2 (4%)       1 (2%)       5 (10%)                               
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                   2 (4%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (2%)                                                          
      Squamous Cell Carcinoma                                                                 4 (8%)                                
      Mediastinum, Osteosarcoma, Metastatic, Bone      1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Chondroma                                        1 (2%)                                                                       
      Esthesioneuroblastoma                                                      1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
   Pleura                                                          (2)                       (2)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (50%)                   1 (50%)                               
      Histiocytic Sarcoma                                           1 (50%)                                                         
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)          (1)          (1)                                    
      Adenoma                                                                                 1 (100%)                              
      Carcinoma                                                     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Liposarcoma                                                                1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Lung                                               2 (4%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Transitional Epithelium, Papilloma                                         1 (2%)       1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           3 (6%)                                                          
      Leukemia Mononuclear                            16 (32%)     23 (46%)     29 (58%)     25 (50%)                               
      Mesothelioma Malignant                           2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  11                                                               
NTP Experiment-Test: 88124-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:01:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          50          50                                       
     Total Primary Neoplasms                          142         186         203         197                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          48          48          48                                       
     Total Benign Neoplasms                           112         135         145         142                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          37          42          37                                       
     Total Malignant Neoplasms                         30          51          58          55                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5           2           4                                       
     Total Metastatic Neoplasm                          7           7           2          17                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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