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TDMS Study 88124-03 Pathology Tables

NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35

                                                    FINAL#1 CORE STUDY RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  09/25/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1



NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0|             
                                           | 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X     X  X  X     X  X     X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X                 X  X     X                       X     X            |             
      Eosinophilic Focus                   | X                                                                        |             
      Fatty Change                         |       2        2                          1                    1         |             
      Hepatodiaphragmatic Nodule           |             X                                               X  X  X      |             
      Inflammation, Granulomatous          |             2                                                            |             
      Mixed Cell Focus                     |                                              X     X  X                  |             
      Regeneration                         |                2                                                         |             
      Vacuolization Cytoplasmic, Focal     |             2                                                        1   |             
      Bile Duct, Hyperplasia               |       2        2                                                        1|             
      Centrilobular, Necrosis              |       2                                                                 1|             

                                            __________________________________________________________________________|             
   Mesentery                               |    +        +     +                                                     +|             
      Fat, Necrosis                        |    3        3     3                                                     2|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4                                            3     2               |             
      Basophilic Focus                     |          X                                                               |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      4   |             
      Basophilic Focus                     |                X                                                         |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                            2                                             |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                         +   |             
      Inflammation, Chronic Active         |                            4                                         3   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        2        2  2  2     1     2     2  2     1  1  2  2  1  2  1   |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                      3                                            2      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0|             
                                           | 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    2  2           2     3  1  2              2     1     2               |             
      Hypertrophy                          |                1              2                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  3              2                    1                              |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                4                                                         |             
      Pars Distalis, Hyperplasia           |    4  3  3                    1                    4  4                  |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  3  3  2  2  1  2  2  3     2  3  2     2        2  2  3  2  3     1  1|             
      Follicular Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                 3                                                |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2           4  1        3                           |             
      Inflammation, Granulomatous          |                                                                          |             
      Interstitial Cell, Hyperplasia       | 3                                                                        |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Hypertrophy                  |                                                                          |             

                                            __________________________________________________________________________|             
   Vagina                                  |    +                                                                     |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Myelofibrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                                                   |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  M  +  M  M  M  M  M  M  +  +  +  +  M  M  +  +  M  M  M  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  +  M  M  M  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 6| 7| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 1| 3| 3| 3| 2| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 3| 6| 3| 6| 0|             
                                           | 7| 5| 7| 7| 4| 5| 6| 7| 6| 4| 6| 7| 6| 7| 7| 6| 0| 6| 5| 7| 5| 9| 7| 6| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        | 3     3                                                        1         |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     |                                           2                    2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 1                        |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         | 1                       1                                   1            |             
      Thrombosis                           |       3                                                              1   |             
      Alveolar Epithelium, Hyperplasia     |          1  1        2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                  1  1     1  1     1  1                  |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2                    2     2              2                              |             
      Thrombosis                           |                                                                         1|             
      Olfactory Epithelium, Metaplasia     |                                           2                              |             
      Respiratory Epithelium, Hyperplasia  |                      3     3                                             |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                              4                           |             
      Retina, Atrophy                      |                                              4                           |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  1  1  2  2     1  2  1     1  2  1     2  2     1  2  1  2  1  1      |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     46     |
      Clear Cell Focus                     |                      X  X  X     X        X     X  X  X  X  X     X      |     17     |
      Eosinophilic Focus                   |                         X                                                |      2     |
      Fatty Change                         |                                                                          |      4  1.5|
      Hepatodiaphragmatic Nodule           |                      X              X     X                              |      7     |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Mixed Cell Focus                     | X                                X                                   X   |      6     |
      Regeneration                         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                            2                             1               |      4  1.5|
      Bile Duct, Hyperplasia               |             1                                                            |      4  1.5|
      Centrilobular, Necrosis              |             1                                                            |      3  1.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +        +                 +        +                     |   9        |
      Fat, Necrosis                        |       3        3        2                 3        2                     |      9  2.7|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                 1                 1      |      5  2.2|
      Basophilic Focus                     |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2                                                              2   |      3  2.7|
      Basophilic Focus                     |                                                    X                 X   |      3     |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                       1                  |      2  1.5|
      Ulcer                                |             3                                                            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                          +               |   1        |
      Hyperplasia, Squamous                |                                                          1               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       |    2  1  2  1     1  2  1  2     2     2  2  1  2  1  1  2  2  2  2  1  1|     37  1.6|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                         2                                                |      3  2.3|
      Hyperplasia                          |    2           1     2     2        2  2  2  3  1           2  2  2      |     21  1.9|
      Hypertrophy                          |          2     3           2     3  2        1     3        2        4   |     11  2.3|
      Vacuolization Cytoplasmic            |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         1                 2                              |      6  1.8|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  I  M  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +|  40        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      2                                                   |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           | 4  4              4              3  2  4           4        4     3      |     15  3.4|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      C-Cell, Hyperplasia                  | 2  2  2  3  2  1  1  2  2  3     2  1  2  2  2  2  2  2  1        2     3|     41  2.0|
      Follicular Cell, Hyperplasia         |                                                 2                        |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    3                       3                          2                  |      5  2.8|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          2           3     2     2                 4                     |      9  2.6|
      Inflammation, Granulomatous          |    3                                2                                    |      2  2.5|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cervix, Hypertrophy                  |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Granulomatous          |                   1                                                      |      1  1.0|
      Myelofibrosis                        |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  M  M  M  M  M  +  +  M  M  M  +  +  +  +  +  M  +|  25        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  M  M  +  M  M  M  M  +  M  M  +  +  M  +  +  M  +|  28        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |             1                                                  2         |      2  1.5|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |          2                 2                             3               |      6  2.3|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epiglottis, Metaplasia, Squamous     |                                        4                                 |      3  2.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |             1                                   1                    1   |      4  1.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                        X                                 |      1     |
      Inflammation, Chronic Active         |          1     1  1                 1     1           1              1   |     10  1.0|
      Thrombosis                           |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                            2  3     1           1           1            |      8  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      1  1  1     1           1  1  1        1  1     1   |     16  1.0|
      Bronchiole, Inflammation, Suppurative|                                        4                                 |      1  4.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 2                                                  1                     |      6  1.8|
      Thrombosis                           |             3                                                            |      2  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 5| 7| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3|            |
                                           | 7| 5| 6| 7| 1| 6| 7| 7| 5| 5| 0| 5| 1| 6| 6| 6| 6| 6| 7| 6| 7| 7| 5| 7| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                     +                                    |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 1  2  2  1     1  1  1  2  2  1  2     2  2  1  2     2  1  2  2  3  3  2|     41  1.6|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|             
                                           | 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3                                                                     |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Basophilic Focus                     | X     X  X  X     X     X  X     X  X  X  X  X     X  X        X  X  X  X|             
      Clear Cell Focus                     |                               X                 X                 X      |             
      Eosinophilic Focus                   |                                                 X  X                    X|             
      Fatty Change                         |                            2                                             |             
      Hepatodiaphragmatic Nodule           |          X        X                             X                        |             
      Inflammation, Granulomatous          |                                                 3                        |             
      Necrosis                             |                      2           2                          2            |             
      Regeneration                         |                            2                                             |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               | 2                          2                    4        3           1   |             
      Centrilobular, Necrosis              | 2              2           2                                             |             

                                            __________________________________________________________________________|             
   Mesentery                               | +                 +                    +  +              +  +  +        +|             
      Fat, Necrosis                        | 3                 2                    3  3              3  3  2        2|             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                       +                  |             
      Pharyngeal, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                                3                    1                  |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                      1                                                   |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                2                                            1           2|             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +               |             
      Hyperplasia, Squamous                |                                                          4               |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        2        1     1     2  1     2     1  1  2  2        1  1  2   |             
      Atrium, Thrombosis                   |                3                                                         |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|             
                                           | 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Degeneration, Cystic                 |                                                       3                  |             
      Hyperplasia                          | 2           3     3     2        1  2        2     2  2           2     2|             
      Hypertrophy                          | 2     2                                2  2                          2   |             
      Necrosis                             | 2                                                        3  2            |             
      Thrombosis                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                                2  2                       2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3                                                                        |             
      Pars Distalis, Hyperplasia           | 3     2                 2                 4  4                          3|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     1  2  3        1  2  3     2  2  2  2  2  1  1  2  2  2  1  2  1  1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                    3                     |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2     2                 2                       2                     |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                         +               |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  M  M  +  M  M  M  +  M  M  M  M  +  M  M  M  M  +  M  M  +  +  +|             
      Foreign Body                         |                3           1              2              1           3  3|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  A  +  M  M  +  M  +  M  +  M  M  +  M  +  M  M  +  M  +  +  M  +  +  +|             
      Foreign Body                         | 3              3                    3     3        3        3     3  3   |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       2  3                                                              2|             
      Hemorrhage                           |                      3                                                   |             
      Necrosis                             |                                                             2            |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|             
                                           | 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                           2     2  2                     |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                          3               |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                            3        3                                    |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                         2|             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                      2                                                   |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                           4                              |             
      Foreign Body                         | 2  1  2  2  2  2  3  2  3  2  2  2  2  2  2  2  2  2  2  1  2  3  2  2  2|             
      Hyperplasia, Atypical                |             2                       2           4  4                     |             
      Inflammation, Chronic Active         | 3  1  3  3  3  3  4  3  3  3  2  4  4  3  3  3  4  3  2  3  2  3  3  3  2|             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          2        4     2     2  2     2     2                    2     2|             
      Alveolar Epithelium, Metaplasia      | 3     3  4  4     4  3  4  2  3  4  3  4  4  3  4  4  3  3     3  4  3  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Alveolus, Proteinosis                | 3  3  3  4  4  4  4  3  4  2  4  4  4  4  4  3  4  4  4  2  4  4  4  3  4|             
      Interstitium, Fibrosis               | 3     2  3  3  2  4  3  3  2  2  4  3  3  4  3  4  3  2  3  2  2  3  3  3|             
      Mediastinum, Inflammation, Chronic   |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3                          2        2                    3           2   |             
      Thrombosis                           | 2              4                                                         |             
      Lateral Wall, Metaplasia, Squamous   |                                                                          |             
      Olfactory Epithelium, Metaplasia     | 2                                   1                                    |             
      Respiratory Epithelium, Hyperplasia  | 2                                         3                              |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                1         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 5| 7| 7| 6| 7| 4| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 3| 3| 0| 3| 8| 3| 8| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3|             
                                           | 8| 0| 0| 6| 6| 7| 5| 1| 7| 6| 7| 5| 1| 7| 5| 7| 5| 7| 6| 6| 4| 3| 6| 7| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Nephropathy                          | 1           1  1  2     1  1  2  1  2  2     1  2  1  2        2  1  2  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                          2               |      2  2.0|
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X     X  X|     39     |
      Clear Cell Focus                     |             X           X                                   X  X     X   |      8     |
      Eosinophilic Focus                   |                                              X                       X   |      5     |
      Fatty Change                         |                                                       3                  |      2  2.5|
      Hepatodiaphragmatic Nodule           |                                                             X            |      4     |
      Inflammation, Granulomatous          |                                              3                           |      2  3.0|
      Necrosis                             |                                                                          |      3  2.0|
      Regeneration                         |                                              3                           |      2  2.5|
      Vacuolization Cytoplasmic, Focal     |             2                                                            |      1  2.0|
      Bile Duct, Hyperplasia               |    2                                         2                          3|      8  2.4|
      Centrilobular, Necrosis              |    2     1                             2                          2      |      7  1.9|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +                 +           +                       +  +        +|  15        |
      Fat, Necrosis                        | 3     2                 2           2                       2  2        3|     15  2.5|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                +         |   2        |
      Pharyngeal, Hyperplasia              |                                                                3         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    1  1  2     1  1     1           2        2     1                     |     12  1.4|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                  3                                       |      1  3.0|
      Inflammation, Acute                  |                                                       2                  |      1  2.0|
      Ulcer                                |                                  3                                       |      2  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                  3     2                                 |      5  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 1     1        2  2  1  1  2  1     1        2        2  1  2  1     2   |     29  1.4|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                      2     2                                             |      3  2.3|
      Hyperplasia                          |       2     1  1  2     2  2  2     2     2  2              2        2   |     23  2.0|
      Hypertrophy                          | 2  3  2     1     4  1                                      2           2|     13  2.1|
      Necrosis                             |    2                                                                     |      4  2.3|
      Thrombosis                           |                                                                   2      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                   2        2  1           2           3     2  2     2  3|     13  2.2|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                             3            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +|  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                          2               |      2  2.5|
      Pars Distalis, Hyperplasia           |          2        3  3  3        3  2  1                          3     3|     15  2.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      C-Cell, Hyperplasia                  | 3  3  3  1  2  2  1  3  3  2  2     2  2  2  2     4  2  2  2  2        2|     42  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Cyst                                 |                2                                                         |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              2              3            |      6  2.2|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +                                                              +|   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  30        |
      Foreign Body                         | 3  3     3     3        3  2  2  3     3     3        3  3  3  2  2  3  3|     23  2.6|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  36        |
      Foreign Body                         |             3  3           3        3                    4  3  3         |     15  3.1|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                           2                              |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Hemorrhage                           |    2                                                                     |      2  2.5|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                 2                        |      1  2.0|
      Epithelial Cell, Hyperplasia         |                                           2                              |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |             2                                                            |      4  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  49        |
      Hyperkeratosis                       | 4                                                                        |      2  3.5|
      Inflammation, Acute                  |                                                             3            |      1  3.0|
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |       3        3                 2                             2     2   |      7  2.6|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Epiglottis, Metaplasia, Squamous     |                                                 2                 1      |      2  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |       1        1                                   1  2                  |      5  1.4|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                                                                          |      1  4.0|
      Foreign Body                         | 2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  3     2  2  2  3  3  2  3  2|     49  2.1|
      Hyperplasia, Atypical                | 2     2           3                          3                           |      8  2.8|
      Inflammation, Chronic Active         | 3  4  4  2  2  3  3  4  3  3  3  3  4  3  3  4     3  3  4  3  3  3  3  3|     49  3.0|
      Metaplasia, Squamous                 |    2                                      1                              |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |             2              2  2                       1  1           4   |     15  2.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 0| 5| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 8| 3| 9| 3| 3| 3| 3| 9| 3| 1| 9| 3| 2| 9| 3| 3| 3| 3| 2| 3| 3|            |
                                           | 5| 4| 6| 8| 0| 6| 5| 5| 7| 7| 6| 4| 5| 4| 5| 7| 6| 7| 7| 6| 6| 5| 5| 6| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Metaplasia      | 4  3  4  1  1  3  3  4  4  3  1  3  4  4  4  4     3  4  4  4  4  3  4  4|     46  3.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                 1                        |      1  1.0|
      Alveolus, Proteinosis                | 4  4  4  4  4  4  3  4  4  4  4  3  4  3  2  4     3  4  4  4  4  4  4  4|     49  3.7|
      Interstitium, Fibrosis               | 3  4  4  2  2  2  3  3  3  2  2  3  3  3  3  4     2  3  4  4  4  3  3  3|     48  2.9|
      Mediastinum, Inflammation, Chronic   |                                                                      1   |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                   2                                   3                 2|      8  2.4|
      Thrombosis                           |    2                                                                     |      3  2.7|
      Lateral Wall, Metaplasia, Squamous   |                                           2                          1   |      2  1.5|
      Olfactory Epithelium, Metaplasia     |                   2                                   2                  |      4  1.8|
      Respiratory Epithelium, Hyperplasia  |                   3                                   3                  |      4  2.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                           2                             2|      3  1.7|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Accumulation, Hyaline Droplet        |                                           3                              |      1  3.0|
      Nephropathy                          | 1  1  1     2  2  1  1  1  1  3  2        1  3     2  2  2  2  2     3  1|     38  1.6|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8|             
                                           | 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X  X        X                       X     X     X     X  X        X   |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |          2              2  2                                             |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         |                            1                                             |             
      Mixed Cell Focus                     |                                     X                                    |             
      Bile Duct, Hyperplasia               |                               2     2  2                                 |             
      Centrilobular, Necrosis              |                               2                       1                  |             
      Periportal, Infiltration Cellular,   |                                                                          |             
           Mononuclear Cell                |                                                                          |             
      Serosa, Hemorrhage                   |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +  +        +  +                    +  +      |             
      Fat, Necrosis                        |    2                       2  2        2  3                    2  3      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2           1                                4         |             
      Basophilic Focus                     |                                        X           X                     |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                             |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |          2                                                               |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                            3                                             |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2        2  1     1  1  2  2     2  1  1  1  2  1  1  1     1      |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                    3                     |             
      Hyperplasia                          |    3  2  2     1  2     3     2     2  1  1  2        1        2     1  2|             
      Hypertrophy                          |                                                       3           2      |             
      Vacuolization Cytoplasmic            |                                                                3         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8|             
                                           | 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                             2           3                     |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                                 |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  M  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                2                                         2               |             
      Pars Distalis, Hyperplasia           |                      3                                3  2           4  2|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  1  3     2  2  1  2  2  2  2  2  3  1  2  1  3  2  2  2     2     3|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                    3                                            3      |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                           4                              |             
      Ulcer                                |                                           4                              |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1                                                                  |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                +         |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M|             
      Foreign Body                         |                   3  3  3  3  3     3  3     3  2  3  1     3        3   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  M|             
      Foreign Body                         |                         2  2  1     3        3  3           3            |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     2                                    |             
      Hematopoietic Cell Proliferation     |                                           3                              |             
      Hemorrhage                           |                2                                                         |             
      Metaplasia, Osseous                  |                                                       2                  |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 1| 0| 1| 5| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 7| 8| 8|             
                                           | 6| 6| 6| 7| 8| 5| 7| 6| 4| 0| 6| 6| 5| 7| 6| 7| 6| 6| 2| 7| 6| 6| 9| 6| 4|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Galactocele                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      1   |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                              3              4            |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     |                      3                                                   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                      3                                   1  1            |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Foreign Body                         | 2  1  1  1  1  1  2  1  2  2  2  1  3  2  1  2  2  2  2  2  2  2  2  2  2|             
      Hyperplasia, Atypical                |    3                                   3     1                          4|             
      Inflammation, Chronic Active         | 2  2  2  2  3  2  2  2  2  2  3  3  2  3  2  3  2  3  3  2  2  3  2  3  3|             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2  2  2                 4              1     1        3  1  3         |             
      Alveolar Epithelium, Metaplasia      | 2  4  3  4  1  2  3     2  1  1  2  3  4  1  4  1  2     3  1  3  2  2  4|             
      Alveolus, Proteinosis                |    2     1  2  1  2  1  3  2  3  2  2  2  2  3  2  2  1  2  2  2  2  2  2|             
      Interstitium, Fibrosis               | 2  3  3  3  2  2  2  2  2  2  3  3  2  3  2  3  2  3  3  2  2  3  2  2  3|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1           2  2                                                |             
      Thrombosis                           |          1                                                               |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |          1                                                               |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Cataract                             |                                                 4                        |             
      Retina, Atrophy                      |                                                 4                        |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  2  1        1  1  2        2  1  2  1  2  2  2     2  2  2  2  2  1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X|     47     |
      Clear Cell Focus                     |       X     X        X  X        X     X        X              X         |     17     |
      Eosinophilic Focus                   |          X                 X                                   X         |      3     |
      Fatty Change                         |                   2                                                      |      4  2.0|
      Hepatodiaphragmatic Nodule           | X        X                                                               |      2     |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                X                          X                             X|      4     |
      Bile Duct, Hyperplasia               |                                                                2         |      4  2.0|
      Centrilobular, Necrosis              |    2                                                                     |      3  1.7|
      Periportal, Infiltration Cellular,   |                                                                          |            |
           Mononuclear Cell                |                                                                3         |      1  3.0|
      Serosa, Hemorrhage                   |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +  +           +     +  +     +        +                  |  15        |
      Fat, Necrosis                        |          3     2  2           2     2  2     2        3                  |     15  2.3|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                          1     3     2   |      6  2.2|
      Basophilic Focus                     |                      X                                                   |      3     |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  3  2  1  1     1  3  2  1  1  2  2  1  1  1     1  1  2  2  2  2  1|     41  1.5|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |          3                                                               |      2  3.0|
      Hyperplasia                          | 2  2  1     2  2     2  2  2     2           2        2                 3|     27  1.9|
      Hypertrophy                          |                                           1                              |      3  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2        2                    2     1        3              3         |      9  2.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                           1                              |      3  1.7|
      Pars Distalis, Hyperplasia           | 3     2  4        3                             3        1     3  2      |     13  2.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    2     2  2     2  2  2  2  2  1  2  2  2  2  2     2  1  2  3  3  3   |     42  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia                          |       3                                                                  |      2  2.5|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    3     2                          3                             3      |      7  2.9|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                      3   |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +|  35        |
      Foreign Body                         | 2     2     3     3           3  3        4     3  2  3           2  3  3|     26  2.8|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +  +  M  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|  42        |
      Infiltration Cellular, Plasma Cell   |                               4                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  39        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |    3  2     3     2              2     1     3           2     2     3  1|     18  2.3|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 3  3     2                                         2                 2   |      6  2.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        | 3  3                          3                       3                  |      6  3.2|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                    +                     |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epiglottis, Metaplasia, Squamous     |                                                                          |      1  3.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |             3                                                            |      4  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                                                       4                  |      1  4.0|
      Foreign Body                         | 2  2  2  1  2  1  1  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  1.8|
      Hyperplasia, Atypical                |          4                                2           4     2            |      8  2.9|
      Inflammation, Chronic Active         | 3  3  2  3  3  3  3  3  2  2  3  3  3  3  3  3  3  2  3  3  3  3  3  3  3|     50  2.6|
      Metaplasia, Squamous                 |                                     2                                    |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       3     2                 1     3  1  2  2  4     2     2  1  1     1|     22  2.0|
      Alveolar Epithelium, Metaplasia      | 3  2  2  2  2  2  2  2  2  3  2  3  1  2  4  3  2     3  2  3  4  2  1  2|     47  2.4|
      Alveolus, Proteinosis                | 2  2  2  1  2  2  2  2  1  2  2     2  2  3  2  2  4  2  3  2  2  2  2  2|     47  2.0|
      Interstitium, Fibrosis               | 3  3  2  3  3  3  2  3  2  3  3  3  3  3  3  2  3  2  3  3  2  3  2  2  3|     50  2.6|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      3  1.7|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 7| 5| 6| 7| 5| 6| 5| 6| 6| 7| 7| 7| 6| 5| 5| 7| 7| 5| 7| 6| 6| 5| 7| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                     1                                    |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                      +               |   3        |
      Cataract                             |                   3                                      3               |      3  3.3|
      Retina, Atrophy                      |                   3                                      3               |      3  3.3|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          |    1  1  1  1  2  1  2  2  2  2  2  2  2  1  2  2     2     2  2  2  1  2|     42  1.7|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  M|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  4                                       |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X     X  X  X  X  X  X|             
      Clear Cell Focus                     |       X  X     X                             X                    X      |             
      Eosinophilic Focus                   |                      X                                X                  |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X  X  X                    X           X           X     X            |             
      Inflammation, Granulomatous          |                                                       3                  |             
      Mixed Cell Focus                     |          X                    X              X                    X      |             
      Necrosis                             |                                                       2                  |             
      Regeneration                         |                      2                                2                  |             
      Tension Lipidosis                    |                                                                          |             
      Thrombosis                           |                                  3                                       |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |                      2     2     3  1           2     3        2         |             
      Centrilobular, Necrosis              |    1                             1              1              1        2|             

                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +              +     +  +        +     +      |             
      Fat, Necrosis                        |    2                                      2     3  2        2     2      |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                       +                  |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       1                  |             
      Basophilic Focus                     |                                                                          |             
      Metaplasia, Hepatocyte               |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           2                              |             
      Basophilic Focus                     |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                 3                        |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                 3                        |             

                                            __________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
      Hyperplasia, Squamous                |                      2                                                   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  1  1  2     2  2     2           1  1        1  2  1  1     2  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2           3                        |             
      Degeneration, Cystic                 |                                                             2            |             
      Hyperplasia                          | 1     1  2     1        2                 2  2     1        2     3  1   |             
      Hypertrophy                          |                                              2                       1   |             
      Necrosis                             |                                                                         4|             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2           4                             1  2      |             
      Necrosis                             |                                                                         4|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  M  +  M  M  +  M  +  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     1                          3         |             
      Hemorrhage, Chronic                  |                                                 4                        |             
      Pars Distalis, Angiectasis           |          2                                                               |             
      Pars Distalis, Hyperplasia           |       4        3  3           3  3        2                 4  2  2     2|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  1  2  4  3  2        2  2     3  1        2  3  2  2     1  3  3  2   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2              1                                             |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
      Inflammation, Acute                  |                                                                         3|             
      Thrombosis                           |                                                                         3|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                       2                  |             
      Myelofibrosis                        |    1                                                                     |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                      +   |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +  M  +  +  +  +  M|             
      Foreign Body                         | 2  3           4  3  3              2           3  4  3     4  3  2  2   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  M  M  +  M  M|             
      Foreign Body                         |    3        3     3  3  3           3     2     3     2                  |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      3           3                                       |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |             2                                                            |             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                         2|             
      Inflammation, Acute                  |                      3                                                   |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                      3              3                             2      |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                   1      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                           2           2           2      |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |       4        4     4                    2  4                       3   |             
      Foreign Body                         | 2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2|             
      Hyperplasia, Atypical                |       4     4  4  4  4  3  4     2  4     4  4  4  4  2  2        4  4   |             
      Inflammation, Chronic Active         | 4  3  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4|             
      Metaplasia, Squamous                 |                                              3                           |             
      Alveolar Epithelium, Hyperplasia     |             2  2        2                             2  1  3            |             
      Alveolar Epithelium, Metaplasia      | 4  4  4  4  4  4  4  4  4  4     3  4     4  4  4  4  4  4  4  4  4  4  2|             
      Alveolus, Proteinosis                | 4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4  4  4  2  4  4  3|             
      Interstitium, Fibrosis               | 4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2     2                                2              2            |             
      Thrombosis                           |                                     1           3              3         |             
      Glands, Hyperplasia                  |                                                             3            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 1| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 3| 9| 3| 3| 1| 3| 3| 3| 3| 1| 2| 5| 8| 8| 3| 3| 4| 3| 3| 3| 3| 5| 3| 3| 3|             
                                           | 6| 3| 7| 7| 3| 5| 6| 6| 6| 9| 6| 6| 8| 6| 6| 5| 3| 5| 7| 5| 5| 6| 7| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                             2            |             
      Respiratory Epithelium, Hyperplasia  |       1        1                             2              2  2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |       2                                                                  |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cataract                             |                                                                4         |             
      Retina, Atrophy                      |                                                                4         |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                 2                        |             
      Nephropathy                          | 2     2  2  2  2  1  1  1                 2  2     2     2  1  1  2  2   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5|            |
                                           | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     | X     X  X  X  X        X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     44     |
      Clear Cell Focus                     |       X  X  X                                            X               |      9     |
      Eosinophilic Focus                   |                X        X                                X               |      5     |
      Fatty Change                         |    3                                   2  1                              |      3  2.0|
      Hepatodiaphragmatic Nodule           |                         X                 X        X     X               |     11     |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                          |      4     |
      Necrosis                             |                                                             2     2      |      3  2.0|
      Regeneration                         |                                        4  2                              |      4  2.5|
      Tension Lipidosis                    |       X                                                                  |      1     |
      Thrombosis                           |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                     2                                    |      1  2.0|
      Bile Duct, Hyperplasia               |    2                 2                    2                              |     10  2.1|
      Centrilobular, Necrosis              |       2              2                 1  1                              |      9  1.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +     +  +  +                    +              +  +  +  +        +|  19        |
      Fat, Necrosis                        | 2  3  2     2  2  2                    3              3  3  2  2        2|     18  2.3|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                +         |   2        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 1  1        2           2        1                 2                 4   |      8  1.8|
      Basophilic Focus                     |                                  X                                       |      1     |
      Metaplasia, Hepatocyte               |                                                                      2   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                        2                                 |      2  2.0|
      Basophilic Focus                     |          X              X                                                |      2     |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |                   4                    1                                 |      2  2.5|
      Ulcer                                |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Necrosis                             |    3                                                                     |      2  3.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5|            |
                                           | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     2  1                 1  1     2  2  1     1  2  1        1  1  2   |     30  1.4|
      Atrium, Thrombosis                   |    1                                                                     |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      2  2.5|
      Degeneration, Cystic                 |             3                                                            |      2  2.5|
      Hyperplasia                          | 2           2  2           2  2  2  2     2  2  1  2  2  2           2   |     25  1.8|
      Hypertrophy                          |                      1  2     2           2                              |      6  1.7|
      Necrosis                             |       4                 3                                                |      3  3.7|
      Vacuolization Cytoplasmic            | 3                 3                                2        2            |      4  2.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 3  2     2  3           1     1     3     3           2           2  1   |     15  2.1|
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  M  +  +|  39        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      2  2.0|
      Hemorrhage, Chronic                  |                                                                          |      1  4.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |    3  2  2     2  2                             3           2            |     17  2.6|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      C-Cell, Hyperplasia                  |    2  2  2  3  1  3  3  2  2  2  2  2     2  2  2  1  1  2  3     1  1   |     39  2.1|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                     2                             2      |      4  1.8|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                2                                   2              2      |      3  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5|            |
                                           | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  M  M  +  +  M  +  +  M  M  +  M  M  M  M  +  M  M  I  +  M  +|  30        |
      Foreign Body                         | 2     3  2           3     4                                      3     4|     20  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  M  +  +  +  +|  42        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  +  M  M  M  +  +  M  +  M  M  M  M  M  M  M  M  +  M  M|  26        |
      Foreign Body                         |       3  3  2                 4                                          |     13  2.8|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Fibrosis                             |                2              2                                          |      4  2.5|
      Hematopoietic Cell Proliferation     |       4                                                                  |      2  3.5|
      Hemorrhage                           |                   2                                                      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |             2                    2  2                          2         |      5  2.0|
      Hyperplasia                          |                                                             3            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Osteopetrosis                        |                                     3              4              2  4   |      7  3.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                       2                  |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 1| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5|            |
                                           | 7| 5| 6| 7| 5| 7| 1| 7| 7| 6| 6| 0| 6| 7| 6| 6| 7| 5| 6| 7| 6| 5| 8| 7| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Squamous                        |          2                             2              1                  |      6  1.8|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                         4           4        3     4                     |     10  3.6|
      Foreign Body                         | 2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  2.0|
      Hyperplasia, Atypical                | 4  3     4     4     4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|     39  3.8|
      Inflammation, Chronic Active         | 4  3  4  3  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|     49  3.9|
      Metaplasia, Squamous                 |                                           3        2                 2   |      4  2.5|
      Alveolar Epithelium, Hyperplasia     |       2  1  3  1        2  1           1                    2  2     2   |     16  1.8|
      Alveolar Epithelium, Metaplasia      | 4  2  4  4  4  4  3  2  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4|     48  3.8|
      Alveolus, Proteinosis                | 4  2  4  4  4  4  4  4  4  4  4  4  4  4  1  4  4  4  4  4  4  4  4  4  4|     50  3.8|
      Interstitium, Fibrosis               | 4  3  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4|     49  3.9|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                2           2     1        1                             3|      9  1.9|
      Thrombosis                           |    4                 4                 2                                 |      6  2.8|
      Glands, Hyperplasia                  |                                                                          |      1  3.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                            3              2                              |      7  1.9|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                  2                                       |      2  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                     +         |   3        |
      Cataract                             |          3                                                     3         |      3  3.3|
      Retina, Atrophy                      |          4                                                     4         |      3  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          | 2     2  2  3  1  1  2  2  3        2  2  2  1  1  2  2  2  2  1  2  2  1|     38  1.8|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|             
                                           | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2     1                                                            |             
      Basophilic Focus                     | X              X  X        X  X  X  X  X  X        X        X     X     X|             
      Clear Cell Focus                     |    X  X        X  X           X  X        X  X     X                 X  X|             
      Degeneration, Cystic                 |                   2                                         1            |             
      Eosinophilic Focus                   |                      X                          X        X               |             
      Fatty Change                         |             1                                                            |             
      Hepatodiaphragmatic Nodule           |                                                                         X|             
      Inflammation, Granulomatous          | 3                                                                        |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |          2                                                               |             
      Bile Duct, Hyperplasia               | 1  1  2  2  2     1  3     2  1  2  1  1  1  2  2  2     3  2  2  3  1   |             
      Centrilobular, Necrosis              |                                                          1               |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +        +     +                                      +        +   |             
      Fat, Necrosis                        |       3        2     2                                      3        3   |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     1     1                       3                       1  2         |             
      Basophilic Focus                     |                   X                                         X           X|             
      Hyperplasia                          |                         3                          4                     |             
      Thrombosis                           |          3                                                               |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                   X                                                      |             
      Necrosis                             |                      2                                                   |             
      Duct, Metaplasia, Squamous           |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                            X                                             |             
      Hyperplasia, Squamous                |                               4                                          |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           1                              |             
      Necrosis                             |          3                                                               |             

                                            __________________________________________________________________________|             
   Tongue                                  |                +                                                         |             
      Hyperplasia, Squamous                |                3                                                         |             

                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                   +               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|             
                                           | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                      3                                   2               |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Necrosis, Fibrinoid                  |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  3  3     3  1  2  2     2  3  2  2  2  2  3  2  2  1     2     2  2  2|             
      Atrium, Thrombosis                   |                                                          2               |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |    2  2  1              2     2  3  2        1     2        2  2  2  2  2|             
      Hypertrophy                          |                2     1              3                          2         |             
      Necrosis                             |    2                                                                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2           2  2  1     2              3           3  3        2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2        1                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                    2     2           1   |             
      Pars Intermedia, Angiectasis         |                      2                                                   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    4  1  2  2  3  3  2  2  2  1     1     2  2  2  2  1     3  1  1     2|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                      +                                                   |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Inflammation, Chronic Active         |                         2  2                                             |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1              3  4  2                 1        2                 3   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                  2               |             
      Artery, Inflammation, Chronic Active |                3                                                         |             
      Interstitial Cell, Hyperplasia       |          2  1  3                                                         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|             
                                           | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                  2                                       |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Ectasia                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  +  +  M  +  M  M  +  +  +  +  M  +  +  M  M  +  M  +  M  M  M|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  M  +  +  M  M  +  +  +  +  +  +  M  +  +  M  M  +  M  +  M  M  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 3                    2                       2           3               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  +  +  +  +  +  M  +  M  +  M  M  +  M  +  +  +  +|             
      Galactocele                          |                               2     1     3     2                        |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              4                 3         |             
      Epidermis, Hyperplasia               |                                  3                                       |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                       X                  |             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                             1            |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1           1  1              1                                   2  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 4| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 0| 0| 3| 7| 7| 3| 3| 3| 3| 3|             
                                           | 4| 3| 3| 4| 9| 4| 3| 4| 3| 7| 4| 3| 4| 7| 4| 9| 0| 4| 6| 2| 4| 4| 5| 4| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1              1                 1                                       |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         3     2                 1                 3      |             
      Thrombosis                           |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                         3     2                 1  2              3      |             
      Respiratory Epithelium, Hyperplasia  |                                                             2            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  2  2     3  4  2  2  3  1  3  3  2  1  2  3  2  2  1  1  1  1  2  2  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3|            |
                                           | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     |    X  X        X  X     X  X     X  X     X     X        X  X  X  X  X  X|     29     |
      Clear Cell Focus                     |    X                    X           X                       X  X     X  X|     18     |
      Degeneration, Cystic                 |             1                                                            |      3  1.3|
      Eosinophilic Focus                   |                                                                          |      3     |
      Fatty Change                         | 1           2     2                                               2      |      5  1.6|
      Hepatodiaphragmatic Nodule           |                      X                                      X            |      3     |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Mixed Cell Focus                     |       X                                                                  |      1     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1  1  2  2     2  1  2     1  2  1     2     3  1        2  2  2  1     2|     39  1.7|
      Centrilobular, Necrosis              |                1  1           2                       2                  |      5  1.4|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   6        |
      Fat, Necrosis                        |                                  2                                       |      6  2.5|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                              +                           |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2        2     2  2     3        1  2                          2|     14  1.9|
      Basophilic Focus                     |                                                                          |      3     |
      Hyperplasia                          |                                                                          |      2  3.5|
      Thrombosis                           |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                  1           2                           |      2  1.5|
      Basophilic Focus                     |                                     X                                    |      2     |
      Necrosis                             |                                                                          |      1  2.0|
      Duct, Metaplasia, Squamous           |                                                                3         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |    X                                                                     |      2     |
      Hyperplasia, Squamous                |                                                                          |      1  4.0|
      Inflammation, Acute                  |    2                                                                     |      1  2.0|
      Ulcer                                |          3                                                               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3|            |
                                           | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                1                                                         |      2  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                           +                              |   2        |
      Hyperplasia, Squamous                |                                           3                              |      2  3.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |   1        |
      Necrosis, Fibrinoid                  | 2                                                                        |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  3  3  1  3  2  1  1  3  2  1  2  2  1  2  3  2  1        2  2  2  2  3|     44  2.1|
      Atrium, Thrombosis                   |                   3                                                      |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |             2                                                            |      1  2.0|
      Hyperplasia                          |    2  2     2  2     1  2  2     2  2  1  1  2  2  1     2  2  1     1   |     32  1.8|
      Hypertrophy                          |       4                 2                                               2|      7  2.3|
      Necrosis                             | 2                                                                        |      2  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1  1  4  1  3        2  2  2  2  2        3  3        3     1        3|     26  2.2|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                   3     3|      4  2.3|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |                                              3              3            |      5  2.2|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      C-Cell, Hyperplasia                  | 1  1  1  1  2  4     1  1  3  1  1  1  1  2  3  1        1  1  2     2  3|     41  1.8|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |       2                                                                  |      3  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3|            |
                                           | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2                    1  2        1              1  2     1   |     14  1.9|
      Inflammation, Chronic Active         |                                                          4               |      1  4.0|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
      Necrosis                             | 4                                                                        |      1  4.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             3           2     4           4                 4           4|      8  3.3|
      Artery, Inflammation, Chronic Active |             3                                                            |      2  3.0|
      Interstitial Cell, Hyperplasia       |             1        1                          1                        |      6  1.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                         +            |   2        |
      Ectasia                              |                   3                                                      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  M  M  +  +  M  +  +  +  +  +  +  +  M  +  M  M  M  +  +  M  M|  26        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  44        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  M  +  +  +  +  M  M  M  M  +  +  M  M  +  +  M  M  M  +  M  M|  25        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                  3        1                    3        2|      8  2.4|
      Hematopoietic Cell Proliferation     |                   3                                                      |      1  3.0|
      Hemorrhage                           |          2                       2                                       |      2  2.0|
      Hyperplasia, Focal                   |                                                 2                        |      1  2.0|
      Necrosis                             | 2        3                                                               |      2  2.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  +  +  M  M  M  M  M  +  M  +  M  +  +  M  M  +  +  M  M  +  +|  24        |
      Galactocele                          |             2                          1                 1               |      7  1.7|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |    2                             3                                       |      4  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  3.0|
      Prepuce, Inflammation, Chronic Active|                      3                                                   |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 5| 7| 6| 6| 5| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 1| 6| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 6| 3| 0| 5| 3| 5| 3| 5| 3| 3| 9| 3| 3| 2| 3| 3| 0| 0| 3| 7| 3| 3| 4| 9| 3|            |
                                           | 9| 4| 0| 2| 4| 6| 9| 1| 3| 5| 5| 4| 3| 5| 3| 4| 3| 8| 5| 2| 3| 4| 7| 7| 4|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hemorrhage                           |                                                                   2      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                 1              2         |      2  1.5|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                      X   |      1     |
      Inflammation, Chronic Active         |                   1                 1     2     1                        |      5  1.2|
      Inflammation, Suppurative            |                                                                      4   |      1  4.0|
      Thrombosis                           |                                                                1         |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    3        2        1  3                                               1|     11  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                         1              1                 1     4  1      |      8  1.4|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    2                 2     2              2     1                        |      9  2.0|
      Thrombosis                           |                3              1  1                                4      |      4  2.3|
      Olfactory Epithelium, Atrophy        |                                           2                              |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                                           2                              |      6  2.2|
      Respiratory Epithelium, Hyperplasia  |                1        2                       2        2               |      5  1.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                            2                                             |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                   1      |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   1        |
      Cataract                             |                                                 3                        |      1  3.0|
      Retina, Atrophy                      |                                                 4                        |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 2  2  2  2  3  1  1  1  4  3     1  1  1  2  2  3     1  2  2  2  1  3  3|     47  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia | 2                                                                        |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|             
                                           | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 1                        |             
      Basophilic Focus                     | X  X  X  X        X  X  X           X  X  X  X  X  X  X     X  X  X      |             
      Clear Cell Focus                     | X     X  X        X  X                    X     X  X     X  X  X  X      |             
      Degeneration, Cystic                 |       2                                2     1                 1     1   |             
      Eosinophilic Focus                   |       X              X                                               X   |             
      Fatty Change                         |    1        3  2                                                         |             
      Hepatodiaphragmatic Nodule           |       X                                                  X               |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  2  2     2     2  2  2     2  1  2     2  1  1     3  1  1  1  3  2|             
      Centrilobular, Necrosis              |                                                                         1|             

                                            __________________________________________________________________________|             
   Mesentery                               |                         +           +                                    |             
      Fat, Necrosis                        |                         2           2                                    |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1     2  1  1  4  1  1  2                    2      |             
      Basophilic Focus                     |                                                 X                        |             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        2                                 |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |             2                                                            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      1                                                   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    3  2  2     2  3  2     1  2  2  2  2  1  2  2  2  3  1  3  1  3     2|             
      Atrium, Thrombosis                   |             4                                                            |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  3                                   2   |             
      Degeneration, Cystic                 |                                           2                              |             
      Hyperplasia                          | 2     2           2     2  2        2  2  2  2  2     2  2  2     2      |             
      Hypertrophy                          | 3                    1                       2                           |             
      Necrosis                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|             
                                           | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2     2  2  2     2  3  2     2  2  4                          3  3   |             
      Thrombosis                           |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     3                                   2|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |       3                    2           4                 1  2  3     3   |             
      Pars Intermedia, Hyperplasia         |                                                             2            |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    3  2  1  4     2     2  2        2     2  2  1  2  3  2     1  2  1   |             
      Follicular Cell, Hyperplasia         |                               1                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Inflammation, Chronic Active         |                                                 3                        |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1  2  2     1  1                          1                        |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3        3                 3                                          |             
      Necrosis                             |                                                       2                  |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Interstitial Cell, Hyperplasia       | 2              1                 1                                   2   |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                                   +   |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  +  +  +  +  M  +  M  +  M  M  +  M  +  M  M  M  +  +  +  M  +  +|             
      Foreign Body                         |          2     3  2     3              3     3           3  3  1        2|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  +  M  M  M  +  M  +  M  M  M  M  +  M  M  M  M  M  M  M  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|             
                                           | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                                              4                       2   |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          2  2  2  3                             1     3  2           2  3|             
      Hematopoietic Cell Proliferation     |                         4                                                |             
      Hyperplasia, Focal                   |                                                                   3      |             
      Necrosis                             |             3                                                            |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  M  +  +  +  +  M  +  M  M  +  +  +  M  +  M  M  +  +  M  M  +|             
      Galactocele                          |                2        2                                                |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                        2                                 |             
      Inflammation, Acute                  |       2                                      2                           |             
      Epiglottis, Metaplasia, Squamous     |                                        2                                 |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                   4      |             
      Foreign Body                         | 3  2  3  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  3  2  2  2  3  2|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Atypical                | 4     4  4           2  3  2     4  4     2  2              2  4         |             
      Inflammation, Chronic Active         | 4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  3|             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                        2                                 |             
      Alveolar Epithelium, Hyperplasia     | 4     2        1     2                       4     2     1  4  2         |             
      Alveolar Epithelium, Metaplasia      | 4  4  4  4     3  3  4  2  4  4  4  4  4  4  2  4  3  3  4  4  4  4      |             
      Alveolus, Proteinosis                | 4  4  4  4  4  4  4  4  4  4  4  2  4  3  4  3  4  4  4  4  3  4  4  4  3|             
      Interstitium, Fibrosis               | 4  4  4  4  3  3  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4     3|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2           2        3              2                          2        3|             
      Thrombosis                           |             2                                                            |             
      Olfactory Epithelium, Atrophy        |             2     1                                                      |             
      Olfactory Epithelium, Metaplasia     | 2                                                                        |             
      Respiratory Epithelium, Hyperplasia  |             2        2                                         3        3|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 5| 3| 3| 1| 3| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 0| 3|             
                                           | 3| 3| 5| 3| 8| 8| 4| 5| 4| 4| 5| 4| 3| 3| 3| 4| 3| 4| 3| 3| 3| 3| 4| 0| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.03                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    MG/M3                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             

                                            __________________________________________________________________________|             
   Pleura                                  |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2                 1                                                   |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                         4|             
      Nephropathy                          | 4  3  2  2     3  2  2  2  2  2     3  4  2  2  2  2  2  2  1  2  4     1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                          4               |      2  2.5|
      Basophilic Focus                     | X     X  X  X     X  X  X                       X  X     X     X     X   |     29     |
      Clear Cell Focus                     |                                        X              X           X  X   |     16     |
      Degeneration, Cystic                 |       1                                2        2           2            |      9  1.6|
      Eosinophilic Focus                   |                                                                          |      3     |
      Fatty Change                         |                2                    2                                    |      5  2.0|
      Hepatodiaphragmatic Nodule           |                                                       X           X      |      4     |
      Inflammation, Chronic Active         |                                                                         1|      1  1.0|
      Necrosis                             |    3                                                                     |      1  3.0|
      Bile Duct, Hyperplasia               | 1        2  2  2  2  2  2  2  2  2     2  3  2  3  2  2  2  2  2  2  2  1|     42  1.9|
      Centrilobular, Necrosis              |                               3  1                 1                     |      4  1.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +           +                             +               |   6        |
      Fat, Necrosis                        |             3  2           2                             3               |      6  2.3|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                         2                 2     2  1     2     1  2      |     16  1.7|
      Basophilic Focus                     |                                        X                    X            |      3     |
      Hyperplasia                          |             2                                                        3   |      2  2.5|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2                                                           1      |      3  1.7|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  2  3  2  2  1  3  2  1  3     1     3  2  1  2  2  2  1  2  2  2  3   |     43  2.0|
      Atrium, Thrombosis                   |                2                                   1                     |      3  2.3|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      2  2.5|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |       2     3        2           2     2  2  2  2  2  4     2  2     2   |     27  2.1|
      Hypertrophy                          |          2                                               2               |      5  2.0|
      Necrosis                             |    3                          2                                          |      2  2.5|
      Vacuolization Cytoplasmic            |                                     3                                    |      1  3.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3  2  1  1  2  4           3     3              2     2     3  2     3   |     26  2.4|
      Thrombosis                           |                               3                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                1                                                         |      3  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia                          |                                                       3                  |      1  3.0|
      Hypertrophy                          |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                 2                 2      |      2  2.0|
      Pars Distalis, Hyperplasia           |                            3     3  2     2     1  2                     |     13  2.4|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2  1  2        2  1     1     2  3  1        2     1  1  1              1|     31  1.8|
      Follicular Cell, Hyperplasia         |                                              1                           |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |    +                                                                     |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                3                                                         |      2  3.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               1  2        3        2        1  3        1|     13  1.6|
      Inflammation, Chronic Active         |                                                          4               |      1  4.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2                                                                     |      4  2.8|
      Necrosis                             |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                        2                                 |      1  2.0|
      Interstitial Cell, Hyperplasia       |    1                 1                 2                                 |      7  1.4|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |    2                                                                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                           +     +                        |   4        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  M  +  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  M  M  +  M  M|  27        |
      Foreign Body                         |             3  3  3           2           1  3     3     3        3      |     19  2.6|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|  42        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  M  M|  19        |
      Foreign Body                         |                                     3  3  1  3        3           3      |      8  2.8|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          2  3                 2                    1        3        1   |     15  2.1|
      Hematopoietic Cell Proliferation     |    3                                                                     |      2  3.5|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  M|  33        |
      Galactocele                          | 3                                                        3               |      4  2.5|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                   X      |      1     |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                            2                                             |      3  2.0|
      Epiglottis, Metaplasia, Squamous     |          2                                                               |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                                                                          |      1  4.0|
      Foreign Body                         | 2  2  2  2  2  1  2  3  2  3  2  2  2  2  2  2  2  2  2  3  2  3  2  2  2|     50  2.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 6| 2| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 8| 3| 0| 3| 4| 0| 8| 6| 0| 8| 9| 8| 3| 3| 7| 3| 8| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 5| 3| 3| 2| 4| 3| 1| 6| 9| 7| 5| 5| 5| 3| 3| 6| 3| 6| 4| 4| 4| 4| 4| 5| 6|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.03                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    MG/M3                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                   4                                                      |      1  4.0|
      Hyperplasia, Atypical                |             4     4  2                                                  3|     16  3.1|
      Inflammation, Chronic Active         | 4  3  4  4  4  3  4  4  4  4  3  4  3  4  4  4  4  4  4  3  4  4  4  4  4|     50  3.8|
      Inflammation, Suppurative            |          4                                                               |      1  4.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    3     2     1     2     2     3        2     3        4  2        2   |     20  2.4|
      Alveolar Epithelium, Metaplasia      | 2  1  4  3  4  2  4  2  2  3  2        1  4  2  2  2  2  2  3  3  4  4  3|     45  3.1|
      Alveolus, Proteinosis                | 4  4  4  3  4  3  4  4  4  4  3  4  3  4  3  4  3  3  4  4  4  4  4  4  4|     50  3.7|
      Interstitium, Fibrosis               | 3  3  4  4  4  3  4  4  3  3  2  4  3  4  4  4  4  3  4  4  4  4  4  4  4|     49  3.7|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |             2                          2  1                             1|     10  2.0|
      Thrombosis                           |    4                          3                    2                     |      4  2.8|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.5|
      Olfactory Epithelium, Metaplasia     |       1                                                                  |      2  1.5|
      Respiratory Epithelium, Hyperplasia  |             2                          3  2                              |      7  2.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                1         |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pleura                                  |    +                             +                                       |   2        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                            1                                             |      3  1.3|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   1        |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy                          | 4  2  4  3  2  1  2  1  2  2  1  3     4  2  1  2  1  3  3  2  4  2  4  2|     46  2.3|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|             
                                           | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X        X  X  X  X  X     X  X  X     X  X     X  X     X     X     X|             
      Clear Cell Focus                     | X              X  X              X  X        X     X     X        X  X   |             
      Degeneration, Cystic                 |             2           3              2                          2      |             
      Eosinophilic Focus                   |             X                                                     X      |             
      Fatty Change                         |       1  3                    2                                         1|             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Necrosis                             |                                                                          |             
      Regeneration                         |          3              2                                            3   |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               | 2     2  2  3  2  1     3  3  2  1  1  3  1     2  2     1     3  2  2  1|             
      Centrilobular, Necrosis              |             1           2  1           1                                 |             
      Serosa, Fibrosis                     |                                                                          |             
      Serosa, Hemorrhage                   |          2                                                               |             

                                            __________________________________________________________________________|             
   Mesentery                               |             +     +        +              +                 +            |             
      Fat, Metaplasia, Osseous             |                   2                                                      |             
      Fat, Necrosis                        |             2     3        2              2                 2            |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                            +   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1     1           1           2        1              2   |             
      Basophilic Focus                     |                                  X        X           X                  |             
      Hyperplasia                          |                               3                          3        2      |             
      Duct, Hyperplasia                    |          2                                                               |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |             2                                                            |             
      Necrosis                             |             2                                                            |             
      Ulcer                                |          4                                                               |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Mineralization                       |                   1                             3                        |             
      Necrosis                             |                                        1                                 |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
      Developmental Malformation           |                                  X                                       |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|             
                                           | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  1  1  2  3  2  2  1  3  2  3  2  1     2  2  2  2  2  3  3  1  3  3  1|             
      Artery, Mineralization               |                                                 2                        |             
      Atrium, Thrombosis                   |                         1                                                |             
      Epicardium, Fibrosis                 |                         3                                                |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                         3|             
      Hyperplasia                          | 2     1  2     2     2  3     2        1  2  2     2  2  1        2  2  2|             
      Hypertrophy                          |          1              2                                                |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3           3        4  3  3  2           2  2        3        2  3  1  3|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                   4         |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 3                          3        2  2                                 |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1  1  2  1     2  3  1  2  1  1  1  1  4  1  3  1  1     1     2  2|             
      Follicular Cell, Hyperplasia         |                         2                                                |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             4                                               4            |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |             3                                               3            |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3  2     2           2     1  1  3           1            |             
      Inflammation, Chronic Active         |                                     3           2                        |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
      Germinal Epithelium, Degeneration    |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|             
                                           | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M|             
      Foreign Body                         | 3  1        3        3  3     2     4     3     2  3     3  3  3  3  3   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 3  3                 3  1        1  3        3     3  3  3     3     3   |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |          2              3     2                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis                             |                                        2                                 |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M|             
      Galactocele                          |                                                       3                  |             
      Inflammation, Chronic                |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                         X                    X                           |             
      Inflammation, Acute                  |                                              3                           |             
      Necrosis                             |                                                                4         |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 3                        |             
      Artery, Inflammation                 |             3                                                            |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       1                                3           1                     |             
      Epiglottis, Metaplasia, Squamous     | 1                                                                        |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                   3                                                      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 9| 6| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 0| 3| 3| 1| 3| 7| 3| 6| 4| 3| 9| 5|             
                                           | 3| 3| 7| 2| 3| 4| 4| 3| 4| 8| 4| 4| 3| 0| 3| 5| 0| 4| 9| 3| 5| 4| 3| 8| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.1MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         | 1  2  3  2  1  1  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  3  2|             
      Hyperplasia, Atypical                | 4     2        4  4  2     4           4  4  4           1        4      |             
      Inflammation, Chronic Active         | 4  4  3  3  3  3  3  3  3  4  3  4  3  4  4  4  4  4  3  3  4  3  3  3  4|             
      Metaplasia, Squamous                 |                                              3                           |             
      Alveolar Epithelium, Hyperplasia     | 2           2  4     2              2     2  3  1        2        3     1|             
      Alveolar Epithelium, Metaplasia      | 4  3  2  2  2  4  4  2     3  2  4  3  4  4  4  4  4  2  3  3     4  1  1|             
      Alveolus, Proteinosis                | 1  3  3  2  1  2  3  1  1  3  1  2  1  2  2     1  2  2  1  3  2  1  3  3|             
      Artery, Mediastinum, Mineralization  |                                                 2                        |             
      Interstitium, Fibrosis               | 4  3  3  3  3  4  4  3  3  4  4  4  3  4  4  4  4  4  3  4  3  3  4  3  4|             
      Mediastinum, Thrombosis              |                                                                      3   |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1                       2  3                 2              1         |             
      Thrombosis                           |                            1                                             |             
      Lateral Wall, Metaplasia, Squamous   |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                               2                                          |             
      Respiratory Epithelium, Hyperplasia  |                            3  2     3                                    |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +                                                                        |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    3                                            2                        |             
      Infarct                              |                            2                                             |             
      Mineralization                       |                                                 2                        |             
      Nephropathy                          | 2     2     2  2  3  2  3     3  2  2  1  1  2  3  3  2  2  2  1  2  1  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          2                                      3                        |             
      Inflammation, Chronic Active         |                                                 3                        |             
      Transitional Epithelium, Hyperplasia |          2                                                               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4|            |
                                           | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X     X     X        X     X  X  X  X     X  X  X  X  X            |     31     |
      Clear Cell Focus                     | X     X           X     X  X        X  X  X     X  X  X     X            |     22     |
      Degeneration, Cystic                 |             2                                                            |      5  2.2|
      Eosinophilic Focus                   |                                  X                       X               |      4     |
      Fatty Change                         |                               3              2                    3      |      7  2.1|
      Hepatodiaphragmatic Nodule           |                      X                                                   |      2     |
      Necrosis                             |                                                                      2   |      1  2.0|
      Regeneration                         |                                                                          |      3  2.7|
      Vacuolization Cytoplasmic, Focal     |                                  2                                       |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  1  2  1     2  2  2  1     2  1  2     2  2     1  3  2     3  2  1|     40  1.9|
      Centrilobular, Necrosis              |          2           2                                                   |      6  1.5|
      Serosa, Fibrosis                     |                                                             2            |      1  2.0|
      Serosa, Hemorrhage                   |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   6        |
      Fat, Metaplasia, Osseous             |                                                                          |      1  2.0|
      Fat, Necrosis                        | 2                                                                        |      6  2.2|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                             +            |   3        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  2     1  1     1  3        1        2  2        2                 1   |     17  1.6|
      Basophilic Focus                     |                                                                          |      3     |
      Hyperplasia                          |                                                       3                  |      4  2.8|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                3                                                     2  1|      3  2.0|
      Inflammation, Acute                  |                3                                                     2   |      3  2.3|
      Necrosis                             |                                                                          |      1  2.0|
      Ulcer                                |    3                                                     3           3   |      4  3.3|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                          |      2  2.0|
      Necrosis                             |                               2                                          |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4|            |
                                           | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tooth                                   | +           +                                                            |   3        |
      Developmental Malformation           |                                                                          |      1     |
      Inflammation, Chronic Active         | 3           4                                                            |      2  3.5|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  3  2     2  2  3  1  3  2  2  3  3        1  2     2  2     2     2|     43  2.1|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                                   4      |      2  2.5|
      Epicardium, Fibrosis                 |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hyperplasia                          |    2  2     2  1        2  2        1  2  2  2  2     2  2  2     2  2  3|     33  1.9|
      Hypertrophy                          |                                  2                                       |      3  1.7|
      Necrosis                             |                      3                       2                           |      2  2.5|
      Vacuolization Cytoplasmic            |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1        4  4  3        1           1           2  1     3        2  2   |     24  2.4|
      Necrosis                             |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     2                                    |      3  3.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |                      4  2  3  4                 2     2  4  2            |     12  2.8|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 3     2  1  1  1  3     1     2  1  2  3  1  2  2  1     2  1  1  1  2  1|     42  1.6|
      Follicular Cell, Hyperplasia         |                                                       1                  |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                       +                  |   1        |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  4.0|
      Hyperplasia                          |                                     2                                    |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4|            |
                                           | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1     2                    4     1                    3                  |     13  2.0|
      Inflammation, Chronic Active         |                                                          4               |      3  3.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             3                    4              3                 4      |      5  3.4|
      Germinal Epithelium, Degeneration    |                               2                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |    1     2     1  1  2                          2                        |      6  1.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  41        |
      Foreign Body                         | 2     1     3     2  3     2              3  3  3  3     3           3   |     27  2.7|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Plasma Cell   |             4                                                            |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Foreign Body                         | 3  3  3  3  2  3     2  3        3              3     3  3     3     3  4|     27  2.8|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                3         |      1  3.0|
      Fibrosis                             |       2           3              3              2  1                 3   |      9  2.3|
      Hemorrhage                           |    3                          2                                          |      2  2.5|
      Hyperplasia, Focal                   |                                  3                                       |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +|  46        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  +  +  +  M  +  M  +  +  +  M  +  M  M  +  I  +  +  +  +  +  M|  31        |
      Galactocele                          |             2                                                  2  2      |      4  2.3|
      Inflammation, Chronic                |                                  3                                       |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4|            |
                                           | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                               1                                   1      |      5  1.4|
      Epiglottis, Metaplasia, Squamous     |                                                                          |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                   2      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                   3                                         3            |      3  3.0|
      Foreign Body                         | 2  2  2  2  2  2  2  2  2  1  1  1  2  2  2  2  2  2  2  2  2  2  1  2  1|     50  1.9|
      Hyperplasia, Atypical                | 4     4           2  2  4           4  2  4     4  4  4        2         |     23  3.3|
      Inflammation, Chronic Active         | 4  3  3  3  4  3  3  4  4  3  3  3  4  3  3  3  4  4  4  3  3  3  4  4  3|     50  3.4|
      Metaplasia, Squamous                 |                                                    4        2            |      3  3.0|
      Alveolar Epithelium, Hyperplasia     |             3     2                 1  2  2     2  2  2  2  2            |     21  2.1|
      Alveolar Epithelium, Metaplasia      | 4  1  3        2  3  2  4  3     2  1  3  3  1  4  4  4  2  4  1  4  2  1|     45  2.8|
      Alveolus, Proteinosis                | 2  3  1  2  1  3  1  3  2  1  3  2  2  2  2  3     2  2  1  3  2  4  1  3|     48  2.0|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  2.0|
      Interstitium, Fibrosis               | 4  3  4  2  4  2  4  4  4  4  2  4  4  3  3  3  4  4  4  3  4  3  4  4  3|     50  3.5|
      Mediastinum, Thrombosis              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      1           2                                1      |      8  1.6|
      Thrombosis                           |    1                 2        4              3                    4      |      6  2.5|
      Lateral Wall, Metaplasia, Squamous   |             2                                                            |      1  2.0|
      Olfactory Epithelium, Atrophy        |                                           1                              |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                  3                                       |      2  2.5|
      Respiratory Epithelium, Hyperplasia  |                      2                                                   |      4  2.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                   2      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   1        |
      Cataract                             |                                  4                                       |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 6| 6| 6|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 5| 4| 4|            |
                                           | 3| 3| 4| 7| 5| 0| 4| 0| 4| 4| 3| 4| 3| 4| 5| 2| 4| 4| 5| 4| 3| 5| 1| 4| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    0.1MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Retina, Atrophy                      |                                  4                                       |      1  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      2  2.5|
      Infarct                              |                                                                   2      |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 3     3  1  2  1  3  1  2  3     3  3  4  2     2  2  2  2  3     2  3  1|     43  2.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|             
                                           | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                3                                    |             
      Basophilic Focus                     |    X  X     X  X        X  X     X  X  X  X        X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |    X  X           X        X           X           X           X  X  X   |             
      Degeneration, Cystic                 |                            1              2                              |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                      2                                1                  |             
      Hepatodiaphragmatic Nodule           |                            X     X     X  X                              |             
      Inflammation, Granulomatous          |                               2                                          |             
      Mixed Cell Focus                     |             X                                                            |             
      Necrosis                             |                2                                                         |             
      Bile Duct, Hyperplasia               |    2  1  1  2     2     2        2  2     2     3  2  2  2  2  2  2      |             
      Centrilobular, Necrosis              |                                                       2                 2|             

                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +        +     +                       +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |                      2           3        2     2                        |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Abscess                    |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1        2     2  2              2  1  3     2     2      |             
      Hyperplasia                          |                2                             2                           |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                   X      |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                       2                  |             
      Hyperplasia, Squamous                |                2                                                         |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   1                    1                                 |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|             
                                           | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  2     1  2  2     1  2  2  2  2  2  3  1  3  1  2     2  2  2  2   |             
      Necrosis                             |                                                          2               |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Mesothelium, Hyperplasia             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
      Degeneration, Cystic                 |                            3                                             |             
      Hyperplasia                          | 2  2  2  2  3     2  2  2           2  2              2  3  2  1  2  2   |             
      Hypertrophy                          |       1                    3                                2            |             
      Necrosis                             |                                                    3                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  2           2  2  1  3  3     2  4     2  2     3     2  2  2  4   |             
      Thrombosis                           |                                                                         1|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             1                                                            |             
      Pars Distalis, Hyperplasia           |             2     3                                3     2     4  3  2  1|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  2     2  2  1  1  2  2     1     1           1  1  1  3  2  1  1  2|             
      Follicular Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                        2        2  2                     |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                   2  1  1        1              2      |             
      Inflammation, Chronic Active         |                                                       4                  |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   4        3  4  2     4              3              3   |             
      Artery, Inflammation, Chronic Active |                               2                                      3   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|             
                                           | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                      1     1                 1                           |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +              +|             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Foreign Body                         | 2  1  4  3  3     3  3     3  3     2  3  2  3           3     4  4      |             
      Hyperplasia                          |                   2                                                      |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                    3                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  M  M  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       3           3  2                 3           4        3     4     1|             
      Hyperplasia                          |                   2                                                      |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   1                 2     2     3  1        3     2      |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                  2                                       |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   4                                                      |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  M  M  M  +  +  M  M  +  +  M  M  M  M  +  M  +  +  M  +  M|             
      Galactocele                          | 3                          2                                             |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       4                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                2                                                        2|             
      Inflammation, Acute                  |                                                                         1|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                           2                              |             
      Foreign Body                         | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  3|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 3| 8| 3| 6| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 7| 3| 3| 3| 3| 3| 6|             
                                           | 6| 4| 3| 7| 3| 4| 5| 0| 4| 3| 3| 5| 3| 3| 3| 5| 0| 3| 6| 2| 5| 5| 3| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.3MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     STOP                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Atypical                | 4  4  4  4  4  4  4     4  4  4  4  4  4  4        4  4        4  4  4   |             
      Inflammation, Chronic Active         | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Metaplasia, Squamous                 |                                                    1           3     2   |             
      Alveolar Epithelium, Hyperplasia     | 3  3  2        2  2     2  3  3  2     3  3        2        3  2  3  3   |             
      Alveolar Epithelium, Metaplasia      | 4  2  2     4  4  2  2  4  3  4  3  2  4  4  2  4  4  4  4  4  4  4  4  4|             
      Alveolus, Proteinosis                | 4  3  3  4  3  3  4  4  3  4  2  2     3  3  4     4  1  4  3  3  4  4  4|             
      Interstitium, Fibrosis               | 4  4  4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  2|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1                    1  2     2                       3            |             
      Thrombosis                           |                                                          2              4|             
      Glands, Hyperplasia                  |                                                                          |             
      Olfactory Epithelium, Metaplasia     |       1                    2  1                             1            |             
      Respiratory Epithelium, Hyperplasia  |                               3     2                       3            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Necrosis     |                                                                          |             

                                            __________________________________________________________________________|             
   Pleura                                  |                                                                         +|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      2   |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                   +                                                      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Infarct                              |                4                                                         |             
      Nephropathy                          | 3  2  3  2  2  2  2  2  2  2  2     2  2  2     1  2  3     3  2  2  4  2|             
      Renal Tubule, Hyperplasia            |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5|            |
                                           | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  46        |
      Ulcer                                |                                                 3                        |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Necrosis                             |          3                                                               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|  43        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  44        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     | X  X  X     X     X  X  X  X  X  X  X     X     X     X  X     X        X|     34     |
      Clear Cell Focus                     |                   X     X     X           X     X     X        X         |     16     |
      Degeneration, Cystic                 | 2                                      1              2                  |      5  1.6|
      Eosinophilic Focus                   |                            X           X     X                           |      3     |
      Fatty Change                         |          3                                                               |      3  2.0|
      Hepatodiaphragmatic Nodule           |       X           X        X              X                    X         |      9     |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Mixed Cell Focus                     |             X                                                            |      2     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 3  2  3     2  2  1  2  2  2        3  3  3  3  2  1     3  3  1  4     3|     36  2.2|
      Centrilobular, Necrosis              | 1     1        1                             1           3  1     3     1|     10  1.6|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +                    +  +         |   8        |
      Artery, Inflammation, Chronic Active |                                                                3         |      1  3.0|
      Artery, Mineralization               |                                                                3         |      1  3.0|
      Fat, Necrosis                        |                                        1                    3            |      6  2.2|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                   +              +                                       |   2        |
      Gingival, Abscess                    |                                  4                                       |      1  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2              2  2        2  2     2                 1     3  2        2|     19  1.9|
      Hyperplasia                          |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                 2              2         |      2  2.0|
      Basophilic Focus                     |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |          4                                                               |      2  3.0|
      Ulcer                                |                3                                                         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5|            |
                                           | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                         1                                                |      3  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                         +|   1        |
      Inflammation, Chronic Active         |                                                                         3|      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  3  2  1  2  2  1  2  2  2  3  1  1  1  2  1  2  1  2  2  3  2  2  2  2|     46  1.9|
      Necrosis                             |                                                                          |      1  2.0|
      Artery, Mineralization               |    1                                                                     |      1  1.0|
      Atrium, Thrombosis                   |       4                                                                  |      1  4.0|
      Mesothelium, Hyperplasia             |                                           1                              |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hyperplasia                          |    3  2  1  2  2  1  2  2        2  3     2     2     2     2  1  2     3|     33  2.0|
      Hypertrophy                          | 2                       2              2  2                    2        3|      9  2.1|
      Necrosis                             | 3                                                        1  3            |      4  2.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2     2     2  2  3  2     2  1  1  3     2        4     2  2  3  2   |     32  2.3|
      Thrombosis                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |             1     3              4     2  2                 4     1      |     15  2.5|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      C-Cell, Hyperplasia                  | 1  2  1        1  2  1  1  2  2  1  1  2     2  1  1  2     2  2  1      |     37  1.5|
      Follicular Cell, Hyperplasia         |                                                             1            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Penis                                   | +                                                                        |   1        |
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5|            |
                                           | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                3                                                         |      1  3.0|
      Inflammation, Chronic Active         |                                                    2                     |      4  2.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                          1              1                              |      9  1.4|
      Inflammation, Chronic Active         |                                                             2        4   |      3  3.3|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3                          4     4                                    |     10  3.4|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
      Interstitial Cell, Hyperplasia       |    2           1              2                          2  1           1|      9  1.3|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                         3|      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
      Foreign Body                         |    3  1  3        3  4  3  2  3     2  2  2  2  4  2  4  2  1  3  3  3   |     36  2.7|
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M|  40        |
      Foreign Body                         |       3              3     2                       4  3  3     3         |     15  2.9|
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Fibrosis                             |                            2              1  3  2                        |     11  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                          1               |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Necrosis                             |                                                                         2|      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  M  M  +  +  M  +  +  M  M  +  M  +  M  +  M  M  +  +  +  +  +|  24        |
      Galactocele                          |       2                                      2     2                     |      5  2.2|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |                         4                             3                  |      3  3.7|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5|            |
                                           | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |       4                                      3        3        1         |      4  2.8|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Inflammation, Acute                  |                               3              2                           |      3  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                               4                                          |      2  3.0|
      Foreign Body                         | 2  2  2  3  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2|     50  2.1|
      Hyperplasia, Atypical                | 4  4  4  2  4  2  4  4     4  4     2     4  4  4  4  4     4  4  4  4   |     39  3.8|
      Inflammation, Chronic Active         | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|     50  4.0|
      Metaplasia, Squamous                 |                                              4                           |      4  2.5|
      Alveolar Epithelium, Hyperplasia     | 2  3  2           4  2  3  2  4  2        2  2  3     2  2        4      |     31  2.6|
      Alveolar Epithelium, Metaplasia      | 2  2  2  1  4  1  4  4  4  4  4  1  4  4  4  3  4  4  4  2  2  4  1  4   |     48  3.2|
      Alveolus, Proteinosis                | 2  3  4  4  4  2  4  4  3  4  4  3  4     4  2  4  3  3  4  3  4  4  4  3|     47  3.4|
      Interstitium, Fibrosis               | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|     50  3.9|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    2                             2  1                                    |      8  1.8|
      Thrombosis                           |       2        3                       2                 1  3           2|      8  2.4|
      Glands, Hyperplasia                  |                                                                   2      |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                               1     1                             2      |      7  1.3|
      Respiratory Epithelium, Hyperplasia  |    3                                3                                    |      5  2.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                           3                              |      1  3.0|
      Respiratory Epithelium, Necrosis     |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pleura                                  |                      +                                                   |   2        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   1        |
      Cataract                             |                                        3                                 |      1  3.0|
      Retina, Atrophy                      |                                        4                                 |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88124-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 10/28/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:05:35  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 5| 2| 7| 7| 3| 5| 3| 3| 3| 7| 3| 8| 3| 0| 3| 3| 3| 0| 2| 3| 3| 2| 5|            |
                                           | 8| 4| 6| 5| 1| 2| 3| 8| 5| 4| 3| 2| 4| 6| 4| 6| 4| 0| 3| 3| 8| 4| 4| 1| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    0.3MG/M3                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
     STOP                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                      3                                                   |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy                          | 2  3  2  3  2  1  2  1  2  3  3  2  3  2  2     3  2  3  2  2  2  2  3  2|     46  2.2|
      Renal Tubule, Hyperplasia            |    1                                                                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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