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TDMS Study 88124-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99       
EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 14:14:47       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                      FINAL#1 CORE STUDY RATS                                                       
                                                                                                                                    

               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    CONTROL                                                                       
                                       INCLUDE 002    CONTROL                                                                       
                                       INCLUDE 005    0.1MG/M3 STOP                                                                 
                                       INCLUDE 006    0.1MG/M3 STOP                                                                 
                                       INCLUDE 007    0.3MG/M3 STOP                                                                 
                                       INCLUDE 008    0.3MG/M3 STOP                                                                 
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99     
EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 14:14:47     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 INDIUM PHOSPHIDE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Liver                                  Hepatodiaphragmatic Nodule
Lung                                   Foreign Body
                                       Hyperplasia Atypical
                                       Inflammation Chronic
Lung: Alveolar Epithelium              Hyperplasia
                                       Metaplasia
Lung: Alveolus                         Infiltration Cellular Histiocyte
                                       Proteinosis
Lung: Interstitium                     Fibrosis
Lymph Node, Bronchial                  Foreign Body
Lymph Node, Mediastinal                Foreign Body
Pituitary Gland: Pars Distalis         Hyperplasia
Skin                                   Hyperkeratosis
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hypertrophy
                                       Necrosis
Adrenal Medulla                        Hyperplasia
Heart                                  Cardiomyopathy
Liver                                  Clear Cell Focus
                                       Necrosis
Liver: Bile Duct                       Hyperplasia
Liver: Centrilobular                   Necrosis
Lung                                   Cyst
                                       Foreign Body
                                       Hyperplasia Atypical
                                       Inflammation Chronic
                                       Metaplasia
Lung: Alveolar Epithelium              Hyperplasia
                                       Metaplasia
Lung: Alveolus                         Infiltration Cellular Histiocyte
                                       Proteinosis
Lung: Interstitium                     Fibrosis
Lymph Node, Bronchial                  Foreign Body
Lymph Node, Mediastinal                Foreign Body
Nose                                   Thrombosis
Nose: Respiratory Epithelium           Hyperplasia
Ovary                                  Cyst
Spleen                                 Fibrosis
                                       Hematopoietic Cell Proliferation
===============================================================
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  0/49 (0%)        0/50 (0%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.4%          |  0.0%             0.0%             4.6%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              ---              695           |  ---              ---              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.291          (e)              P=0.494       |  P=0.091          (e)              P=0.245         |
|POLY 3             |        P=0.306          (e)              P=0.510       |  P=0.092          (e)              P=0.245         |
|POLY 1.5           |        P=0.304          (e)              P=0.508       |  P=0.092          (e)              P=0.243         |
|POLY 6             |        P=0.307          (e)              P=0.512       |  P=0.092          (e)              P=0.246         |
|LOGISTIC REGRESSION|        P=0.301          (e)              P=0.507       |  P=0.069          (e)              P=0.194         |
|COCH-ARM / FISHERS |        P=0.296          (e)              P=0.500       |  P=0.090          (e)              P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)     |  3/49 (6%)        2/50 (4%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        2.5%             2.4%             2.4%          |  7.1%             4.5%             4.7%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        1/26 (4%)     |  3/34 (9%)        2/36 (6%)        2/34 (6%)       |
|FIRST INCIDENCE    |        733 (T)          656              733 (T)       |  735 (T)          735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.676N         P=0.746N         P=0.754       |  P=0.464N         P=0.474N         P=0.500N        |
|POLY 3             |        P=0.670N         P=0.754N         P=0.750N      |  P=0.459N         P=0.476N         P=0.493N        |
|POLY 1.5           |        P=0.671N         P=0.756N         P=0.752N      |  P=0.457N         P=0.481N         P=0.492N        |
|POLY 6             |        P=0.670N         P=0.751N         P=0.749N      |  P=0.464N         P=0.470N         P=0.497N        |
|LOGISTIC REGRESSION|        P=0.668N         P=0.758N         P=0.754       |  P=0.464N         P=0.474N         P=0.500N        |
|COCH-ARM / FISHERS |        P=0.680N         P=0.753N         P=0.753N      |  P=0.461N         P=0.490N         P=0.500N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        32/50 (64%)      33/50 (66%)      33/50 (66%)   |  21/49 (43%)      27/50 (54%)      25/49 (51%)     |
|POLY-3 ADJUSTED (b)|        73.1%            72.1%            70.6%         |  47.4%            58.3%            57.8%           |
|TERMINAL (d)       |        22/27 (82%)      21/29 (72%)      20/26 (77%)   |  18/34 (53%)      20/36 (56%)      24/34 (71%)     |
|FIRST INCIDENCE    |        408              460              525           |  124              436              610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.462          P=0.512N         P=0.500       |  P=0.288          P=0.248          P=0.251         |
|POLY 3             |        P=0.453N         P=0.554N         P=0.486N      |  P=0.237          P=0.198          P=0.217         |
|POLY 1.5           |        P=0.510N         P=0.589          P=0.547N      |  P=0.269          P=0.183          P=0.241         |
|POLY 6             |        P=0.391N         P=0.480N         P=0.412N      |  P=0.197          P=0.226          P=0.186         |
|LOGISTIC REGRESSION|        P=0.517N         P=0.560          P=0.551N      |  P=0.322          P=0.198          P=0.292         |
|COCH-ARM / FISHERS |        P=0.482          P=0.500          P=0.500       |  P=0.306          P=0.182          P=0.272         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/50 (14%)       3/50 (6%)        9/50 (18%)    |  11/49 (22%)      3/50 (6%)        6/49 (12%)      |
|POLY-3 ADJUSTED (b)|        17.3%            7.1%             21.0%         |  25.1%            6.7%             14.0%           |
|TERMINAL (d)       |        5/27 (19%)       2/29 (7%)        6/26 (23%)    |  7/34 (21%)       1/36 (3%)        5/34 (15%)      |
|FIRST INCIDENCE    |        700              552              658           |  476              672              727             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.222          P=0.140N         P=0.385       |  P=0.199N         P=0.020N*        P=0.152N        |
|POLY 3             |        P=0.255          P=0.141N         P=0.438       |  P=0.191N         P=0.016N*        P=0.151N        |
|POLY 1.5           |        P=0.250          P=0.146N         P=0.427       |  P=0.184N         P=0.017N*        P=0.142N        |
|POLY 6             |        P=0.256          P=0.135N         P=0.446       |  P=0.203N         P=0.016N*        P=0.166N        |
|LOGISTIC REGRESSION|        P=0.263          P=0.144N         P=0.434       |  P=0.181N         P=0.020N*        P=0.136N        |
|COCH-ARM / FISHERS |        P=0.235          P=0.159N         P=0.393       |  P=0.186N         P=0.018N*        P=0.143N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        4/50 (8%)     |  0/49 (0%)        0/50 (0%)        3/49 (6%)       |
|POLY-3 ADJUSTED (b)|        4.9%             4.7%             9.3%          |  0.0%             0.0%             6.9%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        1/26 (4%)     |  0/34 (0%)        0/36 (0%)        2/34 (6%)       |
|FIRST INCIDENCE    |        569              602              603           |  ---              ---              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.263          P=0.668N         P=0.353       |  P=0.031 *        (e)              P=0.125         |
|POLY 3             |        P=0.265          P=0.683N         P=0.359       |  P=0.029 *        (e)              P=0.124         |
|POLY 1.5           |        P=0.262          P=0.686N         P=0.354       |  P=0.029 *        (e)              P=0.123         |
|POLY 6             |        P=0.265          P=0.678N         P=0.361       |  P=0.029 *        (e)              P=0.123         |
|LOGISTIC REGRESSION|        P=0.235          P=0.676          P=0.342       |  P=0.028 *        (e)              P=0.112         |
|COCH-ARM / FISHERS |        P=0.248          P=0.691N         P=0.339       |  P=0.030 *        (e)              P=0.121         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  1/49 (2%)        1/50 (2%)        4/49 (8%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             0.0%          |  2.4%             2.2%             9.2%            |
|TERMINAL (d)       |        0/27 (0%)        1/29 (3%)        0/26 (0%)     |  1/34 (3%)        1/36 (3%)        3/34 (9%)       |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  735 (T)          735 (T)          411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.715N         P=0.514          (e)           |  P=0.089          P=0.749N         P=0.182         |
|POLY 3             |        P=0.695N         P=0.505          (e)           |  P=0.093          P=0.749N         P=0.188         |
|POLY 1.5           |        P=0.697N         P=0.504          (e)           |  P=0.093          P=0.751N         P=0.188         |
|POLY 6             |        P=0.694N         P=0.507          (e)           |  P=0.091          P=0.746N         P=0.187         |
|LOGISTIC REGRESSION|        (e)              P=0.514          (e)           |  P=0.086          P=0.749N         P=0.168         |
|COCH-ARM / FISHERS |        P=0.704N         P=0.500          (e)           |  P=0.089          P=0.747N         P=0.181         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        26/50 (52%)      24/49 (49%)      32/50 (64%)   |  6/50 (12%)       9/50 (18%)       15/49 (31%)     |
|POLY-3 ADJUSTED (b)|        60.8%            55.0%            69.8%         |  14.1%            20.2%            33.8%           |
|TERMINAL (d)       |        17/27 (63%)      15/28 (54%)      20/26 (77%)   |  6/34 (18%)       9/36 (25%)       11/34 (32%)     |
|FIRST INCIDENCE    |        495              460              525           |  735 (T)          735 (T)          585             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.127          P=0.371N         P=0.186       |  P=0.014 *        P=0.325          P=0.026 *       |
|POLY 3             |        P=0.154          P=0.369N         P=0.240       |  P=0.017 *        P=0.318          P=0.026 *       |
|POLY 1.5           |        P=0.140          P=0.398N         P=0.214       |  P=0.016 *        P=0.307          P=0.024 *       |
|POLY 6             |        P=0.164          P=0.330N         P=0.264       |  P=0.019 *        P=0.330          P=0.029 *       |
|LOGISTIC REGRESSION|        P=0.152          P=0.418N         P=0.225       |  P=0.014 *        P=0.325          P=0.024 *       |
|COCH-ARM / FISHERS |        P=0.106          P=0.460N         P=0.156       |  P=0.014 *        P=0.288          P=0.021 *       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  6/50 (12%)       6/50 (12%)       7/49 (14%)      |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  14.0%            13.5%            16.0%           |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  5/34 (15%)       6/36 (17%)       5/34 (15%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  669              735 (T)          588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.439          P=0.577N         P=0.502         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.459          P=0.594N         P=0.517         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.454          P=0.603N         P=0.510         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.462          P=0.585N         P=0.522         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.442          P=0.572N         P=0.500         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.431          P=0.620N         P=0.484         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  5/49 (10%)       2/47 (4%)        4/49 (8%)       |
|POLY-3 ADJUSTED (b)|                                                        |  12.0%            4.7%             9.0%            |
|TERMINAL (d)       |                                                        |  5/33 (15%)       2/35 (6%)        1/34 (3%)       |
|FIRST INCIDENCE    |                                                        |  735 (T)          735 (T)          519             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.523N         P=0.191N         P=0.483N        |
|POLY 3             |                                                        |  P=0.507N         P=0.210N         P=0.460N        |
|POLY 1.5           |                                                        |  P=0.512N         P=0.219N         P=0.471N        |
|POLY 6             |                                                        |  P=0.503N         P=0.200N         P=0.447N        |
|LOGISTIC REGRESSION|                                                        |  P=0.529N         P=0.191N         P=0.508N        |
|COCH-ARM / FISHERS |                                                        |  P=0.528N         P=0.235N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/1 (100%)       1/1 (100%)       1/1 (100%)    |  1/1 (100%)       3/3 (100%)       3/3 (100%)      |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           100.0%        |  100.0%           100.0%           100.0%          |
|TERMINAL (d)       |        0/0 (0%)         1/1 (100%)       0/0 (0%)      |  1/1 (100%)       1/1 (100%)       2/2 (100%)      |
|FIRST INCIDENCE    |        703              733 (T)          686           |  735 (T)          566              656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 3             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 6             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/1 (100%)       1/1 (100%)       1/1 (100%)    |  1/1 (100%)       3/3 (100%)       3/3 (100%)      |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           100.0%        |  100.0%           100.0%           100.0%          |
|TERMINAL (d)       |        0/0 (0%)         1/1 (100%)       0/0 (0%)      |  1/1 (100%)       1/1 (100%)       2/2 (100%)      |
|FIRST INCIDENCE    |        703              733 (T)          686           |  735 (T)          566              656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 3             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 6             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        44/50 (88%)      43/50 (86%)      46/50 (92%)   |  37/50 (74%)      41/50 (82%)      30/50 (60%)     |
|POLY-3 ADJUSTED (b)|        91.4%            89.0%            96.5%         |  83.7%            86.5%            67.1%           |
|TERMINAL (d)       |        25/27 (93%)      26/29 (90%)      26/26 (100%)  |  32/34 (94%)      32/36 (89%)      25/34 (74%)     |
|FIRST INCIDENCE    |        408              403              525           |  551              436              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.380          P=0.355N         P=0.451       |  P=0.052N         P=0.443          P=0.085N        |
|POLY 3             |        P=0.170          P=0.481N         P=0.239       |  P=0.014N*        P=0.467          P=0.043N*       |
|POLY 1.5           |        P=0.243          P=0.459N         P=0.333       |  P=0.019N*        P=0.355          P=0.059N        |
|POLY 6             |        P=0.105          P=0.500N         P=0.143       |  P=0.010N*        P=0.637          P=0.030N*       |
|LOGISTIC REGRESSION|        P=0.426          P=0.452N         P=0.575       |  P=0.026N*        P=0.361          P=0.063N        |
|COCH-ARM / FISHERS |        P=0.291          P=0.500N         P=0.370       |  P=0.040N*        P=0.235          P=0.101N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        4.9%             4.8%             2.3%          |  0.0%             0.0%             2.3%            |
|TERMINAL (d)       |        0/27 (0%)        1/29 (3%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        639              651              656           |  ---              ---              585             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.376N         P=0.674N         P=0.463N      |  P=0.304          (e)              P=0.513         |
|POLY 3             |        P=0.390N         P=0.688N         P=0.485N      |  P=0.299          (e)              P=0.503         |
|POLY 1.5           |        P=0.393N         P=0.688N         P=0.488N      |  P=0.298          (e)              P=0.502         |
|POLY 6             |        P=0.391N         P=0.687N         P=0.486N      |  P=0.299          (e)              P=0.504         |
|LOGISTIC REGRESSION|        P=0.410N         P=0.695N         P=0.521N      |  P=0.291          (e)              P=0.489         |
|COCH-ARM / FISHERS |        P=0.404N         P=0.691N         P=0.500N      |  P=0.296          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        3/50 (6%)        1/50 (2%)     |  0/50 (0%)        1/50 (2%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        9.8%             7.1%             2.4%          |  0.0%             2.2%             0.0%            |
|TERMINAL (d)       |        2/27 (7%)        1/29 (3%)        1/26 (4%)     |  0/34 (0%)        1/36 (3%)        0/34 (0%)       |
|FIRST INCIDENCE    |        647              644              733 (T)       |  ---              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.140N         P=0.465N         P=0.181N      |  P=0.707N         P=0.511          (e)             |
|POLY 3             |        P=0.133N         P=0.483N         P=0.166N      |  P=0.703N         P=0.509          (e)             |
|POLY 1.5           |        P=0.135N         P=0.488N         P=0.168N      |  P=0.703N         P=0.506          (e)             |
|POLY 6             |        P=0.134N         P=0.477N         P=0.166N      |  P=0.704N         P=0.512          (e)             |
|LOGISTIC REGRESSION|        P=0.132N         P=0.489N         P=0.163N      |  (e)              P=0.511          (e)             |
|COCH-ARM / FISHERS |        P=0.143N         P=0.500N         P=0.181N      |  P=0.708N         P=0.500          (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/48 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              493              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.565N         P=0.247          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.558N         P=0.247          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.562N         P=0.244          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.556N         P=0.251          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.643N         P=0.206          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.575N         P=0.247          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        1/48 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.8%             2.3%          |  0.0%             0.0%             2.4%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              651              684           |  ---              ---              643             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.533          P=0.255          P=0.506       |  P=0.291          (e)              P=0.500         |
|POLY 3             |        P=0.526          P=0.246          P=0.511       |  P=0.294          (e)              P=0.498         |
|POLY 1.5           |        P=0.520          P=0.243          P=0.508       |  P=0.294          (e)              P=0.497         |
|POLY 6             |        P=0.531          P=0.250          P=0.513       |  P=0.294          (e)              P=0.499         |
|LOGISTIC REGRESSION|        P=0.490          P=0.231          P=0.503       |  P=0.272          (e)              P=0.472         |
|COCH-ARM / FISHERS |        P=0.500          P=0.247          P=0.500       |  P=0.289          (e)              P=0.490         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        47/50 (94%)      43/50 (86%)      46/50 (92%)   |  41/50 (82%)      42/50 (84%)      38/48 (79%)     |
|POLY-3 ADJUSTED (b)|        97.7%            94.0%            94.8%         |  91.2%            89.5%            85.9%           |
|TERMINAL (d)       |        27/27 (100%)     29/29 (100%)     26/26 (100%)  |  33/34 (97%)      34/36 (94%)      32/34 (94%)     |
|FIRST INCIDENCE    |        135              460              525           |  476              436              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.536          P=0.171N         P=0.483N      |  P=0.301N         P=0.452N         P=0.326N        |
|POLY 3             |        P=0.367N         P=0.295N         P=0.390N      |  P=0.252N         P=0.535N         P=0.297N        |
|POLY 1.5           |        P=0.449N         P=0.205N         P=0.426N      |  P=0.268N         P=0.612N         P=0.329N        |
|POLY 6             |        P=0.289N         P=0.576N         P=0.390N      |  P=0.283N         P=0.422N         P=0.305N        |
|LOGISTIC REGRESSION|        P=0.277N         P=0.075N         P=0.310N      |  P=0.280N         P=0.518N         P=0.318N        |
|COCH-ARM / FISHERS |        P=0.560N         P=0.159N         P=0.500N      |  P=0.391N         P=0.500          P=0.460N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.6%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              ---              560           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.099          (e)              P=0.251       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.097          (e)              P=0.252       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.095          (e)              P=0.248       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.099          (e)              P=0.256       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.067          (e)              P=0.192       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.091          (e)              P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        5/50 (10%)       3/50 (6%)     |  0/50 (0%)        0/50 (0%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        4.9%             11.7%            7.0%          |  0.0%             0.0%             2.3%            |
|TERMINAL (d)       |        1/27 (4%)        1/29 (3%)        1/26 (4%)     |  0/34 (0%)        0/36 (0%)        1/34 (3%)       |
|FIRST INCIDENCE    |        703              403              560           |  ---              ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.544          P=0.238          P=0.502       |  P=0.293          (e)              P=0.500         |
|POLY 3             |        P=0.576          P=0.239          P=0.528       |  P=0.297          (e)              P=0.501         |
|POLY 1.5           |        P=0.565          P=0.232          P=0.521       |  P=0.297          (e)              P=0.501         |
|POLY 6             |        P=0.583          P=0.249          P=0.534       |  P=0.296          (e)              P=0.500         |
|LOGISTIC REGRESSION|        P=0.507          P=0.207          P=0.510       |  (e)              (e)              P=0.500         |
|COCH-ARM / FISHERS |        P=0.535          P=0.218          P=0.500       |  P=0.292          (e)              P=0.495         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Epiglottis                                                                                                               |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  3/50 (6%)        1/50 (2%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             0.0%          |  7.0%             2.2%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        1/29 (3%)        0/26 (0%)     |  2/34 (6%)        1/36 (3%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  669              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.715N         P=0.514          (e)           |  P=0.090N         P=0.281N         P=0.126N        |
|POLY 3             |        P=0.695N         P=0.505          (e)           |  P=0.089N         P=0.292N         P=0.118N        |
|POLY 1.5           |        P=0.697N         P=0.504          (e)           |  P=0.088N         P=0.296N         P=0.119N        |
|POLY 6             |        P=0.694N         P=0.507          (e)           |  P=0.090N         P=0.287N         P=0.119N        |
|LOGISTIC REGRESSION|        (e)              P=0.514          (e)           |  P=0.087N         P=0.287N         P=0.120N        |
|COCH-ARM / FISHERS |        P=0.704N         P=0.500          (e)           |  P=0.090N         P=0.309N         P=0.125N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Respiratory Epithelium                                                                                                   |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  4/50 (8%)        4/50 (8%)        6/49 (12%)      |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             0.0%          |  9.1%             9.0%             14.0%           |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  1/34 (3%)        4/36 (11%)       6/34 (18%)      |
|FIRST INCIDENCE    |        ---              651              ---           |  550              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.680N         P=0.516          (e)           |  P=0.294          P=0.613N         P=0.373         |
|POLY 3             |        P=0.695N         P=0.507          (e)           |  P=0.282          P=0.636N         P=0.353         |
|POLY 1.5           |        P=0.697N         P=0.505          (e)           |  P=0.289          P=0.637N         P=0.360         |
|POLY 6             |        P=0.694N         P=0.510          (e)           |  P=0.270          P=0.636N         P=0.340         |
|LOGISTIC REGRESSION|        P=0.719N         P=0.494          (e)           |  P=0.294          P=0.640          P=0.361         |
|COCH-ARM / FISHERS |        P=0.704N         P=0.500          (e)           |  P=0.287          P=0.643N         P=0.357         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        4.9%             0.0%             4.7%          |  0.0%             2.2%             2.3%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        2/26 (8%)     |  0/34 (0%)        1/36 (3%)        0/34 (0%)       |
|FIRST INCIDENCE    |        649              ---              733 (T)       |  ---              735 (T)          656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.551          P=0.223N         P=0.693N      |  P=0.414          P=0.511          P=0.490         |
|POLY 3             |        P=0.563          P=0.233N         P=0.679N      |  P=0.430          P=0.509          P=0.502         |
|POLY 1.5           |        P=0.562          P=0.233N         P=0.682N      |  P=0.429          P=0.506          P=0.502         |
|POLY 6             |        P=0.563          P=0.232N         P=0.681N      |  P=0.431          P=0.512          P=0.503         |
|LOGISTIC REGRESSION|        P=0.570          P=0.234N         P=0.677N      |  P=0.424          P=0.511          P=0.498         |
|COCH-ARM / FISHERS |        P=0.554          P=0.247N         P=0.691N      |  P=0.425          P=0.500          P=0.500         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        29/50 (58%)      31/50 (62%)      34/50 (68%)   |  46/50 (92%)      47/50 (94%)      44/50 (88%)     |
|POLY-3 ADJUSTED (b)|        67.6%            72.4%            75.0%         |  97.9%            98.4%            93.0%           |
|TERMINAL (d)       |        20/27 (74%)      27/29 (93%)      23/26 (89%)   |  34/34 (100%)     36/36 (100%)     33/34 (97%)     |
|FIRST INCIDENCE    |        537              493              532           |  476              436              519             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.144          P=0.573          P=0.219       |  P=0.412N         P=0.431N         P=0.428N        |
|POLY 3             |        P=0.264          P=0.395          P=0.282       |  P=0.097N         P=0.815          P=0.223N        |
|POLY 1.5           |        P=0.242          P=0.426          P=0.264       |  P=0.145N         P=0.670          P=0.266N        |
|POLY 6             |        P=0.284          P=0.329          P=0.292       |  P=0.064N         P=0.993          P=0.191N        |
|LOGISTIC REGRESSION|        P=0.268          P=0.506          P=0.303       |  P=0.171N         P=0.696          P=0.267N        |
|COCH-ARM / FISHERS |        P=0.183          P=0.419          P=0.204       |  P=0.267N         P=0.500          P=0.370N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        18/50 (36%)      22/50 (44%)      16/50 (32%)   |  17/50 (34%)      17/50 (34%)      9/50 (18%)      |
|POLY-3 ADJUSTED (b)|        44.4%            53.0%            37.8%         |  39.9%            38.0%            21.0%           |
|TERMINAL (d)       |        16/27 (59%)      21/29 (72%)      16/26 (62%)   |  17/34 (50%)      16/36 (44%)      9/34 (27%)      |
|FIRST INCIDENCE    |        697              698              733 (T)       |  735 (T)          686              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.358N         P=0.339          P=0.462N      |  P=0.029N*        P=0.500N         P=0.041N*       |
|POLY 3             |        P=0.229N         P=0.280          P=0.345N      |  P=0.031N*        P=0.517N         P=0.044N*       |
|POLY 1.5           |        P=0.249N         P=0.283          P=0.362N      |  P=0.032N*        P=0.542N         P=0.047N*       |
|POLY 6             |        P=0.219N         P=0.276          P=0.340N      |  P=0.031N*        P=0.483N         P=0.042N*       |
|LOGISTIC REGRESSION|        P=0.228N         P=0.280          P=0.346N      |  P=0.027N*        P=0.490N         P=0.041N*       |
|COCH-ARM / FISHERS |        P=0.310N         P=0.270          P=0.417N      |  P=0.037N*        P=0.583N         P=0.055N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        5/50 (10%)       5/50 (10%)    |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        7.4%             12.0%            11.7%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        3/27 (11%)       4/29 (14%)       3/26 (12%)    |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        733 (T)          700              686           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.324          P=0.390          P=0.346       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.383          P=0.371          P=0.386       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.375          P=0.368          P=0.379       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.388          P=0.377          P=0.390       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.369          P=0.377          P=0.378       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.349          P=0.357          P=0.357       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        4/50 (8%)        3/50 (6%)     |  2/50 (4%)        3/50 (6%)        5/50 (10%)      |
|POLY-3 ADJUSTED (b)|        7.3%             9.7%             7.0%          |  4.7%             6.7%             11.7%           |
|TERMINAL (d)       |        0/27 (0%)        4/29 (14%)       1/26 (4%)     |  2/34 (6%)        3/36 (8%)        5/34 (15%)      |
|FIRST INCIDENCE    |        600              733 (T)          686           |  735 (T)          735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.572N         P=0.526          P=0.646N      |  P=0.159          P=0.526          P=0.214         |
|POLY 3             |        P=0.548N         P=0.504          P=0.646N      |  P=0.166          P=0.520          P=0.217         |
|POLY 1.5           |        P=0.552N         P=0.506          P=0.648N      |  P=0.168          P=0.513          P=0.218         |
|POLY 6             |        P=0.550N         P=0.500          P=0.648N      |  P=0.163          P=0.528          P=0.215         |
|LOGISTIC REGRESSION|        P=0.545N         P=0.514          P=0.655N      |  P=0.159          P=0.526          P=0.214         |
|COCH-ARM / FISHERS |        P=0.569N         P=0.500          P=0.661N      |  P=0.168          P=0.500          P=0.218         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fatty Change                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       7/50 (14%)       3/50 (6%)     |  4/50 (8%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        12.0%            15.9%            6.9%          |  9.2%             8.8%             6.9%            |
|TERMINAL (d)       |        1/27 (4%)        1/29 (3%)        0/26 (0%)     |  2/34 (6%)        1/36 (3%)        2/34 (6%)       |
|FIRST INCIDENCE    |        569              403              525           |  615              595              585             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.233N         P=0.421          P=0.327N      |  P=0.443N         P=0.599N         P=0.503N        |
|POLY 3             |        P=0.231N         P=0.416          P=0.331N      |  P=0.440N         P=0.615N         P=0.499N        |
|POLY 1.5           |        P=0.236N         P=0.405          P=0.336N      |  P=0.436N         P=0.625N         P=0.498N        |
|POLY 6             |        P=0.233N         P=0.428          P=0.332N      |  P=0.447N         P=0.604N         P=0.503N        |
|LOGISTIC REGRESSION|        P=0.359N         P=0.332          P=0.442N      |  P=0.434N         P=0.634          P=0.499N        |
|COCH-ARM / FISHERS |        P=0.256N         P=0.380          P=0.357N      |  P=0.434N         P=0.643N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        9/50 (18%)    |  7/50 (14%)       2/50 (4%)        11/50 (22%)     |
|POLY-3 ADJUSTED (b)|        7.3%             4.8%             21.0%         |  16.1%            4.5%             25.4%           |
|TERMINAL (d)       |        2/27 (7%)        1/29 (3%)        7/26 (27%)    |  4/34 (12%)       2/36 (6%)        9/34 (27%)      |
|FIRST INCIDENCE    |        551              630              656           |  621              735 (T)          593             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.016 *        P=0.472N         P=0.059       |  P=0.076          P=0.070N         P=0.222         |
|POLY 3             |        P=0.018 *        P=0.491N         P=0.067       |  P=0.070          P=0.072N         P=0.211         |
|POLY 1.5           |        P=0.018 *        P=0.492N         P=0.066       |  P=0.072          P=0.074N         P=0.216         |
|POLY 6             |        P=0.018 *        P=0.487N         P=0.067       |  P=0.066          P=0.071N         P=0.202         |
|LOGISTIC REGRESSION|        P=0.021 *        P=0.498N         P=0.072       |  P=0.075          P=0.073N         P=0.218         |
|COCH-ARM / FISHERS |        P=0.018 *        P=0.500N         P=0.061       |  P=0.079          P=0.080N         P=0.218         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        2/50 (4%)     |  6/50 (12%)       4/50 (8%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        2.5%             0.0%             4.7%          |  13.9%            8.9%             9.3%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        1/26 (4%)     |  4/34 (12%)       3/36 (8%)        3/34 (9%)       |
|FIRST INCIDENCE    |        700              ---              671           |  667              686              726             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.325          P=0.500N         P=0.505       |  P=0.366N         P=0.334N         P=0.377N        |
|POLY 3             |        P=0.331          P=0.495N         P=0.518       |  P=0.362N         P=0.345N         P=0.371N        |
|POLY 1.5           |        P=0.328          P=0.496N         P=0.514       |  P=0.357N         P=0.354N         P=0.368N        |
|POLY 6             |        P=0.332          P=0.495N         P=0.520       |  P=0.370N         P=0.336N         P=0.377N        |
|LOGISTIC REGRESSION|        P=0.331          P=0.495N         P=0.516       |  P=0.358N         P=0.337N         P=0.367N        |
|COCH-ARM / FISHERS |        P=0.320          P=0.500N         P=0.500       |  P=0.354N         P=0.370N         P=0.370N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        2.5%             2.4%             2.3%          |  0.0%             0.0%             6.9%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        2/34 (6%)       |
|FIRST INCIDENCE    |        624              644              684           |  ---              ---              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.665N         P=0.741N         P=0.751N      |  P=0.031 *        (e)              P=0.126         |
|POLY 3             |        P=0.670N         P=0.756N         P=0.751N      |  P=0.029 *        (e)              P=0.121         |
|POLY 1.5           |        P=0.672N         P=0.756N         P=0.753N      |  P=0.029 *        (e)              P=0.121         |
|POLY 6             |        P=0.671N         P=0.754N         P=0.751N      |  P=0.029 *        (e)              P=0.122         |
|LOGISTIC REGRESSION|        P=0.662          P=0.752          P=0.752       |  P=0.031 *        (e)              P=0.121         |
|COCH-ARM / FISHERS |        P=0.680N         P=0.753N         P=0.753N      |  P=0.031 *        (e)              P=0.121         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        0/50 (0%)     |  1/50 (2%)        0/50 (0%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        0.0%             7.1%             0.0%          |  2.3%             0.0%             9.3%            |
|TERMINAL (d)       |        0/27 (0%)        1/29 (3%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        4/34 (12%)      |
|FIRST INCIDENCE    |        ---              552              ---           |  615              ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.505N         P=0.132          (e)           |  P=0.054          P=0.491N         P=0.178         |
|POLY 3             |        P=0.475N         P=0.126          (e)           |  P=0.053          P=0.493N         P=0.177         |
|POLY 1.5           |        P=0.481N         P=0.124          (e)           |  P=0.054          P=0.495N         P=0.179         |
|POLY 6             |        P=0.472N         P=0.129          (e)           |  P=0.052          P=0.491N         P=0.173         |
|LOGISTIC REGRESSION|        P=0.513N         P=0.117          (e)           |  P=0.056          P=0.519N         P=0.180         |
|COCH-ARM / FISHERS |        P=0.500N         P=0.121          (e)           |  P=0.057          P=0.500N         P=0.181         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic Focal                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  4/50 (8%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             0.0%          |  9.2%             0.0%             2.3%            |
|TERMINAL (d)       |        0/27 (0%)        1/29 (3%)        0/26 (0%)     |  2/34 (6%)        0/36 (0%)        1/34 (3%)       |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  566              ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.715N         P=0.514          (e)           |  P=0.168N         P=0.057N         P=0.182N        |
|POLY 3             |        P=0.695N         P=0.505          (e)           |  P=0.167N         P=0.057N         P=0.182N        |
|POLY 1.5           |        P=0.697N         P=0.504          (e)           |  P=0.165N         P=0.058N         P=0.180N        |
|POLY 6             |        P=0.694N         P=0.507          (e)           |  P=0.169N         P=0.056N         P=0.186N        |
|LOGISTIC REGRESSION|        (e)              P=0.514          (e)           |  P=0.165N         P=0.064N         P=0.179N        |
|COCH-ARM / FISHERS |        P=0.704N         P=0.500          (e)           |  P=0.165N         P=0.059N         P=0.181N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        39/50 (78%)      40/50 (80%)      36/50 (72%)   |  4/50 (8%)        4/50 (8%)        10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        82.4%            86.1%            77.2%         |  9.0%             9.0%             22.0%           |
|TERMINAL (d)       |        20/27 (74%)      25/29 (86%)      20/26 (77%)   |  1/34 (3%)        3/36 (8%)        3/34 (9%)       |
|FIRST INCIDENCE    |        495              513              530           |  504              716              519             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.335N         P=0.487N         P=0.362N      |  P=0.040 *        P=0.614N         P=0.091         |
|POLY 3             |        P=0.251N         P=0.417          P=0.347N      |  P=0.036 *        P=0.640N         P=0.078         |
|POLY 1.5           |        P=0.215N         P=0.475          P=0.299N      |  P=0.035 *        P=0.640N         P=0.076         |
|POLY 6             |        P=0.347N         P=0.355          P=0.450N      |  P=0.038 *        P=0.640N         P=0.082         |
|LOGISTIC REGRESSION|        P=0.151N         P=0.565          P=0.232N      |  P=0.034 *        P=0.628          P=0.068         |
|COCH-ARM / FISHERS |        P=0.251N         P=0.500          P=0.322N      |  P=0.035 *        P=0.643N         P=0.074         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       6/50 (12%)       10/50 (20%)   |  3/50 (6%)        3/50 (6%)        9/50 (18%)      |
|POLY-3 ADJUSTED (b)|        11.7%            14.0%            22.5%         |  6.8%             6.7%             20.1%           |
|TERMINAL (d)       |        0/27 (0%)        2/29 (7%)        1/26 (4%)     |  1/34 (3%)        1/36 (3%)        3/34 (9%)       |
|FIRST INCIDENCE    |        135              537              560           |  504              672              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.133          P=0.523          P=0.187       |  P=0.028 *        P=0.631N         P=0.073         |
|POLY 3             |        P=0.104          P=0.498          P=0.144       |  P=0.024 *        P=0.653N         P=0.063         |
|POLY 1.5           |        P=0.100          P=0.498          P=0.139       |  P=0.024 *        P=0.656N         P=0.062         |
|POLY 6             |        P=0.109          P=0.501          P=0.150       |  P=0.025 *        P=0.648N         P=0.066         |
|LOGISTIC REGRESSION|        P=0.051          P=0.428          P=0.064       |  P=0.024 *        P=0.643          P=0.058         |
|COCH-ARM / FISHERS |        P=0.093          P=0.500          P=0.131       |  P=0.025 *        P=0.661N         P=0.061         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        2/50 (4%)     |  0/50 (0%)        1/50 (2%)        10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        0.0%             7.2%             4.7%          |  0.0%             2.2%             23.3%           |
|TERMINAL (d)       |        0/27 (0%)        3/29 (10%)       2/26 (8%)     |  0/34 (0%)        1/36 (3%)        10/34 (29%)     |
|FIRST INCIDENCE    |        ---              733 (T)          733 (T)       |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.291          P=0.133          P=0.229       |  P<0.001 **       P=0.511          P<0.001 **      |
|POLY 3             |        P=0.338          P=0.123          P=0.248       |  P<0.001 **       P=0.509          P<0.001 **      |
|POLY 1.5           |        P=0.332          P=0.122          P=0.246       |  P<0.001 **       P=0.506          P<0.001 **      |
|POLY 6             |        P=0.340          P=0.124          P=0.249       |  P<0.001 **       P=0.512          P<0.001 **      |
|LOGISTIC REGRESSION|        (e)              P=0.133          P=0.229       |  (e)              P=0.511          P<0.001 **      |
|COCH-ARM / FISHERS |        P=0.313          P=0.121          P=0.247       |  P<0.001 **       P=0.500          P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        50/50 (100%)     50/50 (100%)  |  1/50 (2%)        50/50 (100%)     50/50 (100%)    |
|POLY-3 ADJUSTED (b)|        2.5%             100.0%           100.0%        |  2.3%             100.0%           100.0%          |
|TERMINAL (d)       |        0/27 (0%)        29/29 (100%)     26/26 (100%)  |  1/34 (3%)        36/36 (100%)     34/34 (100%)    |
|FIRST INCIDENCE    |        697              403              525           |  735 (T)          225              186             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hyperplasia Atypical                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        23/50 (46%)      39/50 (78%)   |  0/50 (0%)        8/50 (16%)       39/50 (78%)     |
|POLY-3 ADJUSTED (b)|        0.0%             53.2%            83.8%         |  0.0%             17.9%            83.4%           |
|TERMINAL (d)       |        0/27 (0%)        18/29 (62%)      24/26 (92%)   |  0/34 (0%)        7/36 (19%)       29/34 (85%)     |
|FIRST INCIDENCE    |        ---              435              525           |  ---              684              519             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.007 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.004 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.004 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.005 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.006 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.003 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       50/50 (100%)     50/50 (100%)  |  10/50 (20%)      50/50 (100%)     49/50 (98%)     |
|POLY-3 ADJUSTED (b)|        12.3%            100.0%           100.0%        |  22.8%            100.0%           100.0%          |
|TERMINAL (d)       |        3/27 (11%)       29/29 (100%)     26/26 (100%)  |  7/34 (21%)       36/36 (100%)     34/34 (100%)    |
|FIRST INCIDENCE    |        639              403              525           |  476              225              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        4/50 (8%)     |  0/50 (0%)        1/50 (2%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        0.0%             7.2%             9.4%          |  0.0%             2.2%             9.3%            |
|TERMINAL (d)       |        0/27 (0%)        3/29 (10%)       3/26 (12%)    |  0/34 (0%)        1/36 (3%)        4/34 (12%)      |
|FIRST INCIDENCE    |        ---              733 (T)          706           |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.064          P=0.133          P=0.061       |  P=0.024 *        P=0.511          P=0.062         |
|POLY 3             |        P=0.082          P=0.123          P=0.066       |  P=0.024 *        P=0.509          P=0.060         |
|POLY 1.5           |        P=0.080          P=0.122          P=0.065       |  P=0.025 *        P=0.506          P=0.061         |
|POLY 6             |        P=0.083          P=0.124          P=0.067       |  P=0.024 *        P=0.512          P=0.060         |
|LOGISTIC REGRESSION|        P=0.076          P=0.133          P=0.067       |  (e)              P=0.511          P=0.062         |
|COCH-ARM / FISHERS |        P=0.074          P=0.121          P=0.059       |  P=0.026 *        P=0.500          P=0.059         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.5%             0.0%             0.0%          |  4.6%             0.0%             0.0%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        0/26 (0%)     |  1/34 (3%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        733 (T)          ---              ---           |  566              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.402N         P=0.486N         P=0.508N      |  P=0.169N         P=0.226N         P=0.235N        |
|POLY 3             |        P=0.397N         P=0.495N         P=0.490N      |  P=0.173N         P=0.230N         P=0.239N        |
|POLY 1.5           |        P=0.396N         P=0.496N         P=0.492N      |  P=0.172N         P=0.233N         P=0.237N        |
|POLY 6             |        P=0.398N         P=0.493N         P=0.489N      |  P=0.174N         P=0.228N         P=0.241N        |
|LOGISTIC REGRESSION|        P=0.402N         (e)              (e)           |  P=0.173N         P=0.247N         P=0.240N        |
|COCH-ARM / FISHERS |        P=0.394N         P=0.500N         P=0.500N      |  P=0.171N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      21/50 (42%)      31/50 (62%)   |  8/50 (16%)       22/50 (44%)      16/50 (32%)     |
|POLY-3 ADJUSTED (b)|        26.9%            50.3%            70.0%         |  18.3%            48.1%            37.0%           |
|TERMINAL (d)       |        10/27 (37%)      19/29 (66%)      22/26 (85%)   |  5/34 (15%)       20/36 (56%)      15/34 (44%)     |
|FIRST INCIDENCE    |        551              656              603           |  590              436              613             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.028 *        P<0.001 **    |  P=0.122          P=0.004 **       P=0.050         |
|POLY 3             |        P<0.001 **       P=0.020 *        P<0.001 **    |  P=0.110          P=0.002 **       P=0.041 *       |
|POLY 1.5           |        P<0.001 **       P=0.023 *        P<0.001 **    |  P=0.121          P=0.002 **       P=0.045 *       |
|POLY 6             |        P<0.001 **       P=0.018 *        P<0.001 **    |  P=0.095          P=0.002 **       P=0.035 *       |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.024 *        P<0.001 **    |  P=0.129          P=0.003 **       P=0.049 *       |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.026 *        P<0.001 **    |  P=0.138          P=0.002 **       P=0.050         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        45/50 (90%)      48/50 (96%)   |  0/50 (0%)        47/50 (94%)      48/50 (96%)     |
|POLY-3 ADJUSTED (b)|        0.0%             93.3%            97.7%         |  0.0%             96.3%            98.0%           |
|TERMINAL (d)       |        0/27 (0%)        27/29 (93%)      26/26 (100%)  |  0/34 (0%)        35/36 (97%)      34/34 (100%)    |
|FIRST INCIDENCE    |        ---              435              525           |  ---              436              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       0/50 (0%)        0/50 (0%)     |  16/50 (32%)      0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        19.3%            0.0%             0.0%          |  37.2%            0.0%             0.0%            |
|TERMINAL (d)       |        5/27 (19%)       0/29 (0%)        0/26 (0%)     |  14/34 (41%)      0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        525              ---              ---           |  667              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.003N**       P=0.005N**       P=0.005N**    |  P<0.001N**       P<0.001N**       P<0.001N**      |
|POLY 3             |        P<0.001N**       P=0.003N**       P=0.003N**    |  P<0.001N**       P<0.001N**       P<0.001N**      |
|POLY 1.5           |        P<0.001N**       P=0.003N**       P=0.003N**    |  P<0.001N**       P<0.001N**       P<0.001N**      |
|POLY 6             |        P<0.001N**       P=0.003N**       P=0.003N**    |  P<0.001N**       P<0.001N**       P<0.001N**      |
|LOGISTIC REGRESSION|        P=0.002N**       P=0.005N**       P=0.004N**    |  P<0.001N**       P<0.001N**       P<0.001N**      |
|COCH-ARM / FISHERS |        P=0.002N**       P=0.003N**       P=0.003N**    |  P<0.001N**       P<0.001N**       P<0.001N**      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Proteinosis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        48/50 (96%)      47/50 (94%)   |  0/50 (0%)        47/50 (94%)      50/50 (100%)    |
|POLY-3 ADJUSTED (b)|        0.0%             96.0%            94.4%         |  0.0%             94.0%            100.0%          |
|TERMINAL (d)       |        0/27 (0%)        27/29 (93%)      25/26 (96%)   |  0/34 (0%)        33/36 (92%)      34/34 (100%)    |
|FIRST INCIDENCE    |        ---              403              525           |  ---              225              186             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        50/50 (100%)     50/50 (100%)  |  0/50 (0%)        50/50 (100%)     49/50 (98%)     |
|POLY-3 ADJUSTED (b)|        0.0%             100.0%           100.0%        |  0.0%             100.0%           100.0%          |
|TERMINAL (d)       |        0/27 (0%)        29/29 (100%)     26/26 (100%)  |  0/34 (0%)        36/36 (100%)     34/34 (100%)    |
|FIRST INCIDENCE    |        ---              403              525           |  ---              225              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/26 (0%)        27/41 (66%)      36/44 (82%)   |  0/25 (0%)        26/35 (74%)      20/30 (67%)     |
|POLY-3 ADJUSTED (b)|        0.0%             70.9%            83.7%         |  0.0%             75.3%            72.6%           |
|TERMINAL (d)       |        0/12 (0%)        19/27 (70%)      22/26 (85%)   |  0/18 (0%)        19/26 (73%)      13/20 (65%)     |
|FIRST INCIDENCE    |        ---              493              525           |  ---              225              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/25 (0%)        27/45 (60%)      15/40 (38%)   |  0/28 (0%)        18/39 (46%)      13/26 (50%)     |
|POLY-3 ADJUSTED (b)|        0.0%             64.0%            41.2%         |  0.0%             50.1%            59.6%           |
|TERMINAL (d)       |        0/10 (0%)        16/27 (59%)      9/24 (38%)    |  0/17 (0%)        13/29 (45%)      9/14 (64%)      |
|FIRST INCIDENCE    |        ---              435              530           |  ---              566              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.149          P<0.001 **       P=0.002 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P=0.329          P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P=0.206          P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P=0.515          P<0.001 **       P=0.003 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.102          P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P=0.095          P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        7/24 (29%)       4/31 (13%)       5/24 (21%)    |  2/50 (4%)        1/50 (2%)        5/50 (10%)      |
|POLY-3 ADJUSTED (b)|        32.0%            15.1%            22.7%         |  4.6%             2.2%             11.4%           |
|TERMINAL (d)       |        4/14 (29%)       1/18 (6%)        1/13 (8%)     |  1/34 (3%)        1/36 (3%)        3/34 (9%)       |
|FIRST INCIDENCE    |        525              435              530           |  551              735 (T)          610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.393N         P=0.202N         P=0.374N      |  P=0.102          P=0.482N         P=0.222         |
|POLY 3             |        P=0.399N         P=0.142N         P=0.363N      |  P=0.102          P=0.489N         P=0.220         |
|POLY 1.5           |        P=0.407N         P=0.137N         P=0.367N      |  P=0.103          P=0.493N         P=0.219         |
|POLY 6             |        P=0.393N         P=0.142N         P=0.357N      |  P=0.102          P=0.486N         P=0.221         |
|LOGISTIC REGRESSION|        P=0.444N         P=0.095N         P=0.381N      |  P=0.103          P=0.507N         P=0.215         |
|COCH-ARM / FISHERS |        P=0.420N         P=0.124N         P=0.370N      |  P=0.103          P=0.500N         P=0.218         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/6 (100%)       6/6 (100%)       6/8 (75%)     |  9/9 (100%)       15/15 (100%)     18/19 (95%)     |
|POLY-3 ADJUSTED (b)|        100.0%           100.0%           80.6%         |  100.0%           100.0%           98.1%           |
|TERMINAL (d)       |        5/5 (100%)       4/4 (100%)       1/2 (50%)     |  5/5 (100%)       9/9 (100%)       13/13 (100%)    |
|FIRST INCIDENCE    |        714              658              560           |  476              436              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.206          (e)              P=0.296       |  P=0.495          (e)              P=0.504         |
|POLY 3             |        P=0.183N         (e)              P=0.392N      |  P=0.879N         (e)              P=0.988N        |
|POLY 1.5           |        P=0.148N         (e)              P=0.342N      |  P=0.607N         (e)              P=0.860N        |
|POLY 6             |        P=0.248N         (e)              P=0.464N      |  P=1.000N         (e)              P=1.000N        |
|LOGISTIC REGRESSION|        P=0.244N         (e)              P=0.505N      |  P=0.392N         (e)              P=0.634N        |
|COCH-ARM / FISHERS |        P=0.123N         (e)              P=0.308N      |  P=0.395N         (e)              P=0.679N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        9/50 (18%)       8/50 (16%)       8/50 (16%)    |  6/50 (12%)       3/50 (6%)        9/49 (18%)      |
|POLY-3 ADJUSTED (b)|        21.7%            18.4%            18.8%         |  13.7%            6.7%             20.5%           |
|TERMINAL (d)       |        6/27 (22%)       2/29 (7%)        7/26 (27%)    |  4/34 (12%)       2/36 (6%)        6/34 (18%)      |
|FIRST INCIDENCE    |        551              493              672           |  124              714              610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.481N         P=0.449N         P=0.518N      |  P=0.152          P=0.221N         P=0.286         |
|POLY 3             |        P=0.462N         P=0.458N         P=0.476N      |  P=0.150          P=0.233N         P=0.287         |
|POLY 1.5           |        P=0.459N         P=0.472N         P=0.477N      |  P=0.149          P=0.239N         P=0.282         |
|POLY 6             |        P=0.475N         P=0.436N         P=0.483N      |  P=0.151          P=0.226N         P=0.293         |
|LOGISTIC REGRESSION|        P=0.449N         P=0.496N         P=0.453N      |  P=0.137          P=0.261N         P=0.245         |
|COCH-ARM / FISHERS |        P=0.477N         P=0.500N         P=0.500N      |  P=0.147          P=0.243N         P=0.274         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        6/50 (12%)       8/50 (16%)    |  2/50 (4%)        1/50 (2%)        6/49 (12%)      |
|POLY-3 ADJUSTED (b)|        9.6%             13.5%            17.8%         |  4.6%             2.2%             13.5%           |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        1/36 (3%)        1/34 (3%)       |
|FIRST INCIDENCE    |        495              403              532           |  504              735 (T)          585             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.213          P=0.406          P=0.233       |  P=0.053          P=0.488N         P=0.150         |
|POLY 3             |        P=0.191          P=0.408          P=0.215       |  P=0.047 *        P=0.495N         P=0.137         |
|POLY 1.5           |        P=0.180          P=0.396          P=0.203       |  P=0.047 *        P=0.496N         P=0.135         |
|POLY 6             |        P=0.202          P=0.425          P=0.228       |  P=0.048 *        P=0.493N         P=0.139         |
|LOGISTIC REGRESSION|        P=0.078          P=0.300          P=0.120       |  P=0.031 *        P=0.540N         P=0.082         |
|COCH-ARM / FISHERS |        P=0.157          P=0.370          P=0.178       |  P=0.046 *        P=0.500N         P=0.128         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       2/50 (4%)        7/50 (14%)    |  1/50 (2%)        1/50 (2%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        14.7%            4.8%             16.5%         |  2.3%             2.2%             2.3%            |
|TERMINAL (d)       |        5/27 (19%)       2/29 (7%)        7/26 (27%)    |  1/34 (3%)        1/36 (3%)        1/34 (3%)       |
|FIRST INCIDENCE    |        600              733 (T)          733 (T)       |  735 (T)          735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.294          P=0.112N         P=0.475       |  P=0.678          P=0.749N         P=0.762         |
|POLY 3             |        P=0.347          P=0.126N         P=0.530       |  P=0.680          P=0.751N         P=0.760N        |
|POLY 1.5           |        P=0.345          P=0.127N         P=0.525       |  P=0.680          P=0.754N         P=0.760N        |
|POLY 6             |        P=0.344          P=0.124N         P=0.528       |  P=0.679          P=0.747N         P=0.760N        |
|LOGISTIC REGRESSION|        P=0.355          P=0.121N         P=0.539       |  P=0.678          P=0.749N         P=0.762         |
|COCH-ARM / FISHERS |        P=0.331          P=0.134N         P=0.500       |  P=0.675          P=0.753N         P=0.747         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       4/50 (8%)        5/50 (10%)    |  2/50 (4%)        1/50 (2%)        7/49 (14%)      |
|POLY-3 ADJUSTED (b)|        12.2%            9.5%             11.8%         |  4.6%             2.2%             16.2%           |
|TERMINAL (d)       |        2/27 (7%)        2/29 (7%)        5/26 (19%)    |  1/34 (3%)        1/36 (3%)        6/34 (18%)      |
|FIRST INCIDENCE    |        656              630              733 (T)       |  124              735 (T)          656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.559          P=0.468N         P=0.628       |  P=0.020 *        P=0.487N         P=0.082         |
|POLY 3             |        P=0.579          P=0.484N         P=0.610N      |  P=0.018 *        P=0.493N         P=0.075         |
|POLY 1.5           |        P=0.577          P=0.487N         P=0.611N      |  P=0.019 *        P=0.497N         P=0.075         |
|POLY 6             |        P=0.572          P=0.480N         P=0.617N      |  P=0.018 *        P=0.487N         P=0.074         |
|LOGISTIC REGRESSION|        P=0.588N         P=0.487N         P=0.598N      |  P=0.017 *        P=0.567N         P=0.061         |
|COCH-ARM / FISHERS |        P=0.560          P=0.500N         P=0.630N      |  P=0.020 *        P=0.500N         P=0.075         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        2.5%             2.4%             2.4%          |  0.0%             0.0%             4.6%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        1/26 (4%)     |  0/34 (0%)        0/36 (0%)        1/34 (3%)       |
|FIRST INCIDENCE    |        733 (T)          651              733 (T)       |  ---              ---              610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.677N         P=0.743N         P=0.754       |  P=0.090          (e)              P=0.240         |
|POLY 3             |        P=0.670N         P=0.754N         P=0.750N      |  P=0.090          (e)              P=0.240         |
|POLY 1.5           |        P=0.671N         P=0.755N         P=0.752N      |  P=0.090          (e)              P=0.239         |
|POLY 6             |        P=0.670N         P=0.751N         P=0.749N      |  P=0.090          (e)              P=0.241         |
|LOGISTIC REGRESSION|        P=0.668N         P=0.759N         P=0.754       |  P=0.085          (e)              P=0.225         |
|COCH-ARM / FISHERS |        P=0.680N         P=0.753N         P=0.753N      |  P=0.089          (e)              P=0.242         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  9/50 (18%)       7/50 (14%)       3/49 (6%)       |
|POLY-3 ADJUSTED (b)|                                                        |  21.0%            15.6%            6.9%            |
|TERMINAL (d)       |                                                        |  8/34 (24%)       6/36 (17%)       2/34 (6%)       |
|FIRST INCIDENCE    |                                                        |  667              679              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.053N         P=0.341N         P=0.064N        |
|POLY 3             |                                                        |  P=0.047N*        P=0.356N         P=0.055N        |
|POLY 1.5           |                                                        |  P=0.048N*        P=0.369N         P=0.057N        |
|POLY 6             |                                                        |  P=0.047N*        P=0.341N         P=0.054N        |
|LOGISTIC REGRESSION|                                                        |  P=0.049N*        P=0.335N         P=0.060N        |
|COCH-ARM / FISHERS |                                                        |  P=0.054N         P=0.393N         P=0.065N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  2/50 (4%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|                                                        |  4.6%             0.0%             0.0%            |
|TERMINAL (d)       |                                                        |  1/34 (3%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |                                                        |  621              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.174N         P=0.226N         P=0.242N        |
|POLY 3             |                                                        |  P=0.175N         P=0.229N         P=0.238N        |
|POLY 1.5           |                                                        |  P=0.173N         P=0.232N         P=0.238N        |
|POLY 6             |                                                        |  P=0.176N         P=0.227N         P=0.240N        |
|LOGISTIC REGRESSION|                                                        |  P=0.176N         P=0.240N         P=0.245N        |
|COCH-ARM / FISHERS |                                                        |  P=0.173N         P=0.247N         P=0.253N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        14/50 (28%)      17/50 (34%)      19/50 (38%)   |  5/50 (10%)       6/50 (12%)       8/49 (16%)      |
|POLY-3 ADJUSTED (b)|        33.7%            38.2%            43.7%         |  11.7%            13.3%            18.3%           |
|TERMINAL (d)       |        11/27 (41%)      10/29 (35%)      11/26 (42%)   |  5/34 (15%)       4/36 (11%)       6/34 (18%)      |
|FIRST INCIDENCE    |        552              403              658           |  735 (T)          566              585             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.188          P=0.417          P=0.204       |  P=0.233          P=0.540          P=0.280         |
|POLY 3             |        P=0.212          P=0.416          P=0.230       |  P=0.243          P=0.540          P=0.291         |
|POLY 1.5           |        P=0.211          P=0.388          P=0.225       |  P=0.239          P=0.525          P=0.285         |
|POLY 6             |        P=0.208          P=0.452          P=0.233       |  P=0.245          P=0.559          P=0.298         |
|LOGISTIC REGRESSION|        P=0.230          P=0.351          P=0.245       |  P=0.230          P=0.533          P=0.277         |
|COCH-ARM / FISHERS |        P=0.190          P=0.333          P=0.198       |  P=0.222          P=0.500          P=0.264         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        0/50 (0%)     |  1/50 (2%)        3/50 (6%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        7.4%             7.2%             0.0%          |  2.3%             6.7%             2.3%            |
|TERMINAL (d)       |        3/27 (11%)       2/29 (7%)        0/26 (0%)     |  1/34 (3%)        3/36 (8%)        0/34 (0%)       |
|FIRST INCIDENCE    |        733 (T)          679              ---           |  735 (T)          735 (T)          610             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.095N         P=0.633N         P=0.126N      |  P=0.553N         P=0.325          P=0.760         |
|POLY 3             |        P=0.081N         P=0.649N         P=0.109N      |  P=0.542N         P=0.321          P=0.757N        |
|POLY 1.5           |        P=0.083N         P=0.652N         P=0.112N      |  P=0.544N         P=0.315          P=0.759N        |
|POLY 6             |        P=0.080N         P=0.643N         P=0.108N      |  P=0.541N         P=0.327          P=0.757N        |
|LOGISTIC REGRESSION|        P=0.082N         P=0.646N         (e)           |  P=0.551N         P=0.325          P=0.753         |
|COCH-ARM / FISHERS |        P=0.091N         P=0.661N         P=0.121N      |  P=0.557N         P=0.309          P=0.747         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        4/50 (8%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        5.0%             9.7%             4.6%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        2/27 (7%)        4/29 (14%)       0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        733 (T)          733 (T)          545           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.552N         P=0.368          P=0.690N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.502N         P=0.348          P=0.670N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.513N         P=0.346          P=0.677N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.493N         P=0.351          P=0.664N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.518N         P=0.368          P=0.693       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.539N         P=0.339          P=0.691N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/49 (0%)        0/50 (0%)        1/50 (2%)     |  1/50 (2%)        0/48 (0%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.4%          |  2.3%             0.0%             4.6%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        1/26 (4%)     |  1/34 (3%)        0/34 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              ---              733 (T)       |  735 (T)          ---              588             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.285          (e)              P=0.492       |  P=0.317          P=0.500N         P=0.499         |
|POLY 3             |        P=0.306          (e)              P=0.512       |  P=0.325          P=0.500N         P=0.508         |
|POLY 1.5           |        P=0.305          (e)              P=0.511       |  P=0.323          P=0.503N         P=0.504         |
|POLY 6             |        P=0.306          (e)              P=0.512       |  P=0.326          P=0.497N         P=0.512         |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.492       |  P=0.301          (e)              P=0.473         |
|COCH-ARM / FISHERS |        P=0.298          (e)              P=0.505       |  P=0.317          P=0.510N         P=0.492         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/49 (0%)        0/50 (0%)        0/50 (0%)     |  1/50 (2%)        3/48 (6%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.3%             7.1%             2.3%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        3/34 (9%)        1/34 (3%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  615              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.553N         P=0.311          P=0.755         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.547N         P=0.301          P=0.760         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.545N         P=0.298          P=0.760         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.552N         P=0.303          P=0.758         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.547N         P=0.298          P=0.754         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.553N         P=0.293          P=0.747         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/49 (10%)       12/50 (24%)      15/50 (30%)   |  15/50 (30%)      13/48 (27%)      17/49 (35%)     |
|POLY-3 ADJUSTED (b)|        12.5%            27.9%            33.9%         |  34.7%            29.4%            37.5%           |
|TERMINAL (d)       |        4/27 (15%)       8/29 (28%)       9/26 (35%)    |  13/34 (38%)      8/34 (24%)       11/34 (32%)     |
|FIRST INCIDENCE    |        672              403              532           |  621              566              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.017 *        P=0.075          P=0.014 *     |  P=0.334          P=0.388N         P=0.415         |
|POLY 3             |        P=0.025 *        P=0.067          P=0.017 *     |  P=0.385          P=0.384N         P=0.479         |
|POLY 1.5           |        P=0.023 *        P=0.065          P=0.016 *     |  P=0.370          P=0.414N         P=0.454         |
|POLY 6             |        P=0.027 *        P=0.070          P=0.018 *     |  P=0.394          P=0.347N         P=0.500         |
|LOGISTIC REGRESSION|        P=0.022 *        P=0.063          P=0.016 *     |  P=0.333          P=0.423N         P=0.412         |
|COCH-ARM / FISHERS |        P=0.018 *        P=0.059          P=0.013 *     |  P=0.318          P=0.462N         P=0.388         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/50 (2%)     |                                                    |
|POLY-3 ADJUSTED (b)|        0.0%             4.8%             2.3%          |                                                    |
|TERMINAL (d)       |        0/27 (0%)        1/29 (3%)        0/26 (0%)     |                                                    |
|FIRST INCIDENCE    |        ---              665              672           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.515          P=0.251          P=0.517       |                                                    |
|POLY 3             |        P=0.526          P=0.244          P=0.511       |                                                    |
|POLY 1.5           |        P=0.520          P=0.242          P=0.508       |                                                    |
|POLY 6             |        P=0.532          P=0.247          P=0.513       |                                                    |
|LOGISTIC REGRESSION|        P=0.508          P=0.242          P=0.497       |                                                    |
|COCH-ARM / FISHERS |        P=0.500          P=0.247          P=0.500       |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        2/50 (4%)        4/50 (8%)     |                                                    |
|POLY-3 ADJUSTED (b)|        7.3%             4.8%             9.3%          |                                                    |
|TERMINAL (d)       |        1/27 (4%)        1/29 (3%)        2/26 (8%)     |                                                    |
|FIRST INCIDENCE    |        617              665              530           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.392          P=0.480N         P=0.499       |                                                    |
|POLY 3             |        P=0.415          P=0.491N         P=0.528       |                                                    |
|POLY 1.5           |        P=0.410          P=0.493N         P=0.522       |                                                    |
|POLY 6             |        P=0.415          P=0.490N         P=0.529       |                                                    |
|LOGISTIC REGRESSION|        P=0.401          P=0.493N         P=0.507       |                                                    |
|COCH-ARM / FISHERS |        P=0.391          P=0.500N         P=0.500       |                                                    |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        14/50 (28%)      13/50 (26%)      9/50 (18%)    |                                                    |
|POLY-3 ADJUSTED (b)|        34.5%            31.1%            21.1%         |                                                    |
|TERMINAL (d)       |        12/27 (44%)      11/29 (38%)      7/26 (27%)    |                                                    |
|FIRST INCIDENCE    |        697              665              676           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.155N         P=0.417N         P=0.180N      |                                                    |
|POLY 3             |        P=0.103N         P=0.463N         P=0.127N      |                                                    |
|POLY 1.5           |        P=0.113N         P=0.473N         P=0.139N      |                                                    |
|POLY 6             |        P=0.096N         P=0.448N         P=0.118N      |                                                    |
|LOGISTIC REGRESSION|        P=0.101N         P=0.447N         P=0.125N      |                                                    |
|COCH-ARM / FISHERS |        P=0.142N         P=0.500N         P=0.171N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        3/50 (6%)     |                                                    |
|POLY-3 ADJUSTED (b)|        2.5%             7.2%             7.0%          |                                                    |
|TERMINAL (d)       |        0/27 (0%)        2/29 (7%)        0/26 (0%)     |                                                    |
|FIRST INCIDENCE    |        672              710              621           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.318          P=0.324          P=0.337       |                                                    |
|POLY 3             |        P=0.331          P=0.313          P=0.326       |                                                    |
|POLY 1.5           |        P=0.324          P=0.312          P=0.321       |                                                    |
|POLY 6             |        P=0.337          P=0.314          P=0.330       |                                                    |
|LOGISTIC REGRESSION|        P=0.317          P=0.316          P=0.301       |                                                    |
|COCH-ARM / FISHERS |        P=0.302          P=0.309          P=0.309       |                                                    |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  3/50 (6%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        5.0%             0.0%             4.7%          |  6.9%             2.2%             4.7%            |
|TERMINAL (d)       |        2/27 (7%)        0/29 (0%)        2/26 (8%)     |  0/34 (0%)        0/36 (0%)        2/34 (6%)       |
|FIRST INCIDENCE    |        733 (T)          ---              733 (T)       |  566              600              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.536          P=0.222N         P=0.683       |  P=0.500N         P=0.290N         P=0.494N        |
|POLY 3             |        P=0.565          P=0.231N         P=0.677N      |  P=0.510N         P=0.292N         P=0.505N        |
|POLY 1.5           |        P=0.562          P=0.233N         P=0.680N      |  P=0.505N         P=0.297N         P=0.502N        |
|POLY 6             |        P=0.565          P=0.229N         P=0.675N      |  P=0.516N         P=0.287N         P=0.512N        |
|LOGISTIC REGRESSION|        P=0.536          (e)              P=0.683       |  P=0.501N         P=0.323N         P=0.499N        |
|COCH-ARM / FISHERS |        P=0.554          P=0.247N         P=0.691N      |  P=0.500N         P=0.309N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        1/50 (2%)     |  3/50 (6%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        5.0%             0.0%             2.4%          |  6.9%             0.0%             4.7%            |
|TERMINAL (d)       |        2/27 (7%)        0/29 (0%)        1/26 (4%)     |  1/34 (3%)        0/36 (0%)        2/34 (6%)       |
|FIRST INCIDENCE    |        733 (T)          ---              733 (T)       |  615              ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.516N         P=0.222N         P=0.513N      |  P=0.557N         P=0.115N         P=0.504N        |
|POLY 3             |        P=0.496N         P=0.231N         P=0.483N      |  P=0.556N         P=0.113N         P=0.504N        |
|POLY 1.5           |        P=0.497N         P=0.233N         P=0.487N      |  P=0.553N         P=0.115N         P=0.501N        |
|POLY 6             |        P=0.497N         P=0.229N         P=0.481N      |  P=0.560N         P=0.111N         P=0.509N        |
|LOGISTIC REGRESSION|        P=0.516N         (e)              P=0.513N      |  P=0.549N         P=0.121N         P=0.498N        |
|COCH-ARM / FISHERS |        P=0.500N         P=0.247N         P=0.500N      |  P=0.548N         P=0.121N         P=0.500N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/49 (0%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.8%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        2/29 (7%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.590N         P=0.254          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.563N         P=0.243          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.567N         P=0.242          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.560N         P=0.244          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              P=0.254          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.581N         P=0.247          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        3/49 (6%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             7.2%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        3/26 (12%)    |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              ---              733 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.026 *        (e)              P=0.113       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.030 *        (e)              P=0.123       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.029 *        (e)              P=0.122       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.030 *        (e)              P=0.124       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.113       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.029 *        (e)              P=0.117       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        0/50 (0%)        4/49 (8%)     |  0/50 (0%)        1/50 (2%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        9.9%             0.0%             9.5%          |  0.0%             2.2%             0.0%            |
|TERMINAL (d)       |        3/27 (11%)       0/29 (0%)        2/26 (8%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        709              ---              656           |  ---              686              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.456          P=0.057N         P=0.641N      |  P=0.710N         P=0.521          (e)             |
|POLY 3             |        P=0.467          P=0.056N         P=0.624N      |  P=0.705N         P=0.510          (e)             |
|POLY 1.5           |        P=0.463          P=0.058N         P=0.632N      |  P=0.706N         P=0.506          (e)             |
|POLY 6             |        P=0.471          P=0.055N         P=0.617N      |  P=0.705N         P=0.514          (e)             |
|LOGISTIC REGRESSION|        P=0.476          P=0.056N         P=0.625N      |  P=0.708N         P=0.499          (e)             |
|COCH-ARM / FISHERS |        P=0.451          P=0.059N         P=0.631       |  P=0.708N         P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       9/49 (18%)       11/48 (23%)   |  0/50 (0%)        1/50 (2%)        4/47 (9%)       |
|POLY-3 ADJUSTED (b)|        19.6%            21.4%            26.5%         |  0.0%             2.2%             9.6%            |
|TERMINAL (d)       |        5/27 (19%)       7/29 (24%)       9/26 (35%)    |  0/34 (0%)        1/36 (3%)        3/34 (9%)       |
|FIRST INCIDENCE    |        672              552              706           |  ---              735 (T)          656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.242          P=0.553          P=0.289       |  P=0.024 *        P=0.511          P=0.063         |
|POLY 3             |        P=0.274          P=0.528          P=0.315       |  P=0.021 *        P=0.509          P=0.056         |
|POLY 1.5           |        P=0.266          P=0.513          P=0.304       |  P=0.021 *        P=0.506          P=0.056         |
|POLY 6             |        P=0.274          P=0.544          P=0.319       |  P=0.022 *        P=0.512          P=0.057         |
|LOGISTIC REGRESSION|        P=0.295          P=0.525          P=0.334       |  P=0.022 *        P=0.511          P=0.058         |
|COCH-ARM / FISHERS |        P=0.237          P=0.482          P=0.271       |  P=0.021 *        P=0.500          P=0.051         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/49 (0%)        1/48 (2%)     |  1/50 (2%)        6/50 (12%)       2/47 (4%)       |
|POLY-3 ADJUSTED (b)|        2.5%             0.0%             2.4%          |  2.3%             13.0%            4.8%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  1/34 (3%)        4/36 (11%)       1/34 (3%)       |
|FIRST INCIDENCE    |        639              ---              545           |  735 (T)          225              535             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.659          P=0.485N         P=0.747N      |  P=0.604          P=0.069          P=0.502         |
|POLY 3             |        P=0.652          P=0.498N         P=0.754N      |  P=0.609          P=0.070          P=0.493         |
|POLY 1.5           |        P=0.648          P=0.499N         P=0.758N      |  P=0.602          P=0.066          P=0.490         |
|POLY 6             |        P=0.655          P=0.497N         P=0.751N      |  P=0.613N         P=0.074          P=0.496         |
|LOGISTIC REGRESSION|        P=0.568          P=0.517N         P=0.695       |  P=0.508          P=0.043 *        P=0.465         |
|COCH-ARM / FISHERS |        P=0.640          P=0.505N         P=0.742       |  P=0.577          P=0.056          P=0.477         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/49 (4%)        1/48 (2%)     |  1/50 (2%)        1/50 (2%)        1/47 (2%)       |
|POLY-3 ADJUSTED (b)|        4.9%             4.7%             2.4%          |  2.3%             2.2%             2.4%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        1/36 (3%)        0/34 (0%)       |
|FIRST INCIDENCE    |        552              403              603           |  551              735 (T)          411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.394N         P=0.681N         P=0.491N      |  P=0.677N         P=0.749N         P=0.756N        |
|POLY 3             |        P=0.401N         P=0.680N         P=0.493N      |  P=0.672          P=0.754N         P=0.755         |
|POLY 1.5           |        P=0.406N         P=0.686N         P=0.499N      |  P=0.671          P=0.756N         P=0.753         |
|POLY 6             |        P=0.397N         P=0.674N         P=0.488N      |  P=0.672          P=0.752N         P=0.755         |
|LOGISTIC REGRESSION|        P=0.600N         P=0.596          P=0.574N      |  P=0.587          P=0.751          P=0.624         |
|COCH-ARM / FISHERS |        P=0.418N         P=0.684          P=0.515N      |  P=0.664          P=0.753N         P=0.737         |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/49 (2%)        1/48 (2%)     |  0/50 (0%)        0/50 (0%)        0/47 (0%)       |
|POLY-3 ADJUSTED (b)|        4.8%             2.4%             2.4%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        552              700              658           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.431N         P=0.495N         P=0.473N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.448N         P=0.502N         P=0.499N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.451N         P=0.502N         P=0.502N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.447N         P=0.502N         P=0.497N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.534N         P=0.555N         P=0.624N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.459N         P=0.508N         P=0.515N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Diverticulum                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        4.9%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        617              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.171N         P=0.227N         P=0.238N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.169N         P=0.233N         P=0.228N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.169N         P=0.234N         P=0.230N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.168N         P=0.233N         P=0.228N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.170N         P=0.237N         P=0.237N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.171N         P=0.247N         P=0.247N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        2/50 (4%)     |  2/50 (4%)        0/50 (0%)        2/49 (4%)       |
|POLY-3 ADJUSTED (b)|        2.5%             7.0%             4.6%          |  4.6%             0.0%             4.6%            |
|TERMINAL (d)       |        1/27 (4%)        0/29 (0%)        0/26 (0%)     |  1/34 (3%)        0/36 (0%)        1/34 (3%)       |
|FIRST INCIDENCE    |        733 (T)          460              525           |  124              ---              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.522          P=0.331          P=0.509       |  P=0.551          P=0.233N         P=0.692N        |
|POLY 3             |        P=0.536          P=0.326          P=0.524       |  P=0.550          P=0.232N         P=0.694N        |
|POLY 1.5           |        P=0.526          P=0.319          P=0.517       |  P=0.550          P=0.235N         P=0.692         |
|POLY 6             |        P=0.545          P=0.336          P=0.530       |  P=0.548          P=0.229N         P=0.694N        |
|LOGISTIC REGRESSION|        P=0.413          P=0.274          P=0.470       |  P=0.370          P=0.288N         P=0.505         |
|COCH-ARM / FISHERS |        P=0.500          P=0.309          P=0.500       |  P=0.547          P=0.247N         P=0.684         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        2.5%             7.1%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/27 (4%)        1/29 (3%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        733 (T)          460              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.293N         P=0.330          P=0.508N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.274N         P=0.323          P=0.490N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.279N         P=0.318          P=0.492N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.273N         P=0.331          P=0.489N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.321N         P=0.289          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.294N         P=0.309          P=0.500N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        4/50 (8%)        1/50 (2%)     |  1/50 (2%)        0/50 (0%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        2.4%             9.3%             2.3%          |  2.3%             0.0%             2.3%            |
|TERMINAL (d)       |        0/27 (0%)        1/29 (3%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        552              513              672           |  551              ---              643             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.479N         P=0.198          P=0.746N      |  P=0.648          P=0.491N         P=0.758N        |
|POLY 3             |        P=0.479N         P=0.193          P=0.752N      |  P=0.645          P=0.494N         P=0.761         |
|POLY 1.5           |        P=0.482N         P=0.189          P=0.753N      |  P=0.646          P=0.496N         P=0.760         |
|POLY 6             |        P=0.478N         P=0.199          P=0.752N      |  P=0.644          P=0.492N         P=0.760         |
|LOGISTIC REGRESSION|        P=0.595N         P=0.139          P=0.725       |  P=0.598          P=0.536N         P=0.716         |
|COCH-ARM / FISHERS |        P=0.500N         P=0.181          P=0.753N      |  P=0.644          P=0.500N         P=0.747         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/48 (4%)        3/49 (6%)     |  0/49 (0%)        0/50 (0%)        0/48 (0%)       |
|POLY-3 ADJUSTED (b)|        2.5%             4.9%             7.2%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/27 (4%)        1/29 (3%)        3/26 (12%)    |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        733 (T)          710              733 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.235          P=0.525          P=0.290       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.268          P=0.501          P=0.317       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.264          P=0.496          P=0.313       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.271          P=0.507          P=0.320       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.260          P=0.511          P=0.290       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.248          P=0.485          P=0.301       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/48 (4%)        0/49 (0%)     |  1/49 (2%)        1/50 (2%)        2/48 (4%)       |
|POLY-3 ADJUSTED (b)|        4.9%             4.8%             0.0%          |  2.3%             2.2%             4.7%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        624              403              ---           |  551              600              585             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.165N         P=0.678N         P=0.217N      |  P=0.394          P=0.748N         P=0.507         |
|POLY 3             |        P=0.168N         P=0.692N         P=0.233N      |  P=0.392          P=0.750N         P=0.501         |
|POLY 1.5           |        P=0.169N         P=0.692          P=0.234N      |  P=0.392          P=0.752N         P=0.501         |
|POLY 6             |        P=0.169N         P=0.688N         P=0.233N      |  P=0.392          P=0.747N         P=0.502         |
|LOGISTIC REGRESSION|        P=0.232N         P=0.627          P=0.262N      |  P=0.309          P=0.743          P=0.410         |
|COCH-ARM / FISHERS |        P=0.175N         P=0.676          P=0.253N      |  P=0.384          P=0.747N         P=0.492         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       5/50 (10%)       10/50 (20%)   |                                                    |
|POLY-3 ADJUSTED (b)|        19.4%            11.9%            23.4%         |                                                    |
|TERMINAL (d)       |        6/27 (22%)       3/29 (10%)       8/26 (31%)    |                                                    |
|FIRST INCIDENCE    |        495              651              676           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.253          P=0.246N         P=0.380       |                                                    |
|POLY 3             |        P=0.290          P=0.263N         P=0.428       |                                                    |
|POLY 1.5           |        P=0.288          P=0.266N         P=0.423       |                                                    |
|POLY 6             |        P=0.287          P=0.258N         P=0.427       |                                                    |
|LOGISTIC REGRESSION|        P=0.307          P=0.259N         P=0.445       |                                                    |
|COCH-ARM / FISHERS |        P=0.272          P=0.277N         P=0.398       |                                                    |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Artery                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        5.0%             0.0%             4.7%          |                                                    |
|TERMINAL (d)       |        2/27 (7%)        0/29 (0%)        2/26 (8%)     |                                                    |
|FIRST INCIDENCE    |        733 (T)          ---              733 (T)       |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.536          P=0.222N         P=0.683       |                                                    |
|POLY 3             |        P=0.565          P=0.231N         P=0.677N      |                                                    |
|POLY 1.5           |        P=0.562          P=0.233N         P=0.680N      |                                                    |
|POLY 6             |        P=0.565          P=0.229N         P=0.675N      |                                                    |
|LOGISTIC REGRESSION|        P=0.536          (e)              P=0.683       |                                                    |
|COCH-ARM / FISHERS |        P=0.554          P=0.247N         P=0.691N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       6/50 (12%)       9/50 (18%)    |                                                    |
|POLY-3 ADJUSTED (b)|        14.4%            13.7%            20.2%         |                                                    |
|TERMINAL (d)       |        2/27 (7%)        2/29 (7%)        3/26 (12%)    |                                                    |
|FIRST INCIDENCE    |        551              460              545           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.255          P=0.584N         P=0.325       |                                                    |
|POLY 3             |        P=0.259          P=0.587N         P=0.333       |                                                    |
|POLY 1.5           |        P=0.250          P=0.596N         P=0.321       |                                                    |
|POLY 6             |        P=0.265          P=0.580N         P=0.342       |                                                    |
|LOGISTIC REGRESSION|        P=0.169          P=0.585          P=0.261       |                                                    |
|COCH-ARM / FISHERS |        P=0.225          P=0.620N         P=0.288       |                                                    |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        41/49 (84%)      42/48 (88%)      37/48 (77%)   |  41/47 (87%)      42/50 (84%)      39/47 (83%)     |
|POLY-3 ADJUSTED (b)|        89.1%            89.2%            82.2%         |  90.1%            87.7%            84.1%           |
|TERMINAL (d)       |        24/27 (89%)      25/29 (86%)      22/26 (85%)   |  30/34 (88%)      32/36 (89%)      27/33 (82%)     |
|FIRST INCIDENCE    |        476              403              530           |  476              436              411             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.283N         P=0.482N         P=0.315N      |  P=0.485N         P=0.462N         P=0.494N        |
|POLY 3             |        P=0.179N         P=0.632          P=0.242N      |  P=0.253N         P=0.487N         P=0.294N        |
|POLY 1.5           |        P=0.156N         P=0.573          P=0.226N      |  P=0.266N         P=0.456N         P=0.299N        |
|POLY 6             |        P=0.240N         P=0.599N         P=0.298N      |  P=0.244N         P=0.516N         P=0.292N        |
|LOGISTIC REGRESSION|        P=0.119N         P=0.473          P=0.161N      |  P=0.332N         P=0.403N         P=0.363N        |
|COCH-ARM / FISHERS |        P=0.194N         P=0.403          P=0.287N      |  P=0.366N         P=0.436N         P=0.387N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/49 (0%)        2/48 (4%)        1/48 (2%)     |  1/47 (2%)        0/50 (0%)        0/47 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.9%             2.5%          |  2.4%             0.0%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        2/29 (7%)        0/26 (0%)     |  1/34 (3%)        0/36 (0%)        0/33 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          728           |  735 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.492          P=0.254          P=0.507       |  P=0.400N         P=0.489N         P=0.506N        |
|POLY 3             |        P=0.519          P=0.241          P=0.506       |  P=0.398N         P=0.484N         P=0.500N        |
|POLY 1.5           |        P=0.514          P=0.239          P=0.504       |  P=0.397N         P=0.486N         P=0.499N        |
|POLY 6             |        P=0.521          P=0.244          P=0.506       |  P=0.399N         P=0.483N         P=0.502N        |
|LOGISTIC REGRESSION|        P=0.498          P=0.254          P=0.503       |  P=0.400N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.495          P=0.242          P=0.495       |  P=0.395N         P=0.485N         P=0.500N        |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/2 (100%)       0/0 (0%)         0/0 (0%)      |  1/1 (100%)       0/1 (0%)         1/1 (100%)      |
|POLY-3 ADJUSTED (b)|        100.0%           0.0%             0.0%          |  100.0%           0.0%             100.0%          |
|TERMINAL (d)       |        2/2 (100%)       0/0 (0%)         0/0 (0%)      |  1/1 (100%)       0/1 (0%)         1/1 (100%)      |
|FIRST INCIDENCE    |        733 (T)          ---              ---           |  735 (T)          ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.704          P=0.500N         (e)             |
|POLY 3             |        (e)              (e)              (e)           |  P=1.000          P=1.000          (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  P=1.000          P=1.000          (e)             |
|POLY 6             |        (e)              (e)              (e)           |  P=1.000          P=1.000          (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.704          P=0.250N         (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.744          P=0.500N         (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/2 (100%)       2/3 (67%)        1/1 (100%)    |  2/2 (100%)       0/0 (0%)         0/0 (0%)        |
|POLY-3 ADJUSTED (b)|        100.0%           66.7%            100.0%        |  100.0%           0.0%             0.0%            |
|TERMINAL (d)       |        0/0 (0%)         2/3 (67%)        0/0 (0%)      |  0/0 (0%)         0/0 (0%)         0/0 (0%)        |
|FIRST INCIDENCE    |        672              733 (T)          658           |  124              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.496N         P=0.236N         (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.807          P=0.577N         (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.807          P=0.577N         (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.807          P=0.577N         (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              P=0.236N         (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.863          P=0.600N         (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/49 (4%)        0/50 (0%)     |  0/49 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.8%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/27 (0%)        0/29 (0%)        0/26 (0%)     |  0/34 (0%)        0/36 (0%)        0/34 (0%)       |
|FIRST INCIDENCE    |        ---              552              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.567N         P=0.250          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.556N         P=0.243          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.560N         P=0.239          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.554N         P=0.248          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.612N         P=0.217          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.574N         P=0.242          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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