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TDMS Study 88124-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99       

EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 14:09:03       

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       

PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7      

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                      FINAL#1 CORE STUDY RATS                                                       

                                                                                                                                    


               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      

                                       25019 Moribund Sacrifice                                                                     

                                       25020 Natural Death                                                                          

                                       25021 Terminal Sacrifice                                                                     

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    

LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99      

EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 14:09:03      

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124      

PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7     
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      135   408   476   495   525   537   551   552   569   600                 |

 |      617   624   639   647   649   656   672   672   697   700                 |

 |      703   709   714                                                           |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.03    MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      285   526   569   576   586   628   635   643   658   683                 |

 |      684   685   686   695   700   701   702   707   714   714                 |

 |      723                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      403   435   460   493   513   537   552   602   630   644                 |

 |      644   649   651   656   658   665   667   679   698   700                 |

 |      710                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 0.3MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      525   530   532   545   547   560   560   603   621   656                 |

 |      658   658   671   672   672   676   676   684   686   695                 |

 |      706   728   728   730                                                     |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   733 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0  98.0  98.0  98.0  96.0  94.0  88.0  80.0  68.0  54.0      |

 |           |                                                                    |

 |           |                                                                    |

 |0.03       |   100.0 100.0 100.0  98.0  98.0  98.0  96.0  90.0  82.0  58.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.1MG/M3   |   100.0 100.0 100.0 100.0  98.0  94.0  88.0  84.0  68.0  58.0      |

 |STOP       |                                                                    |

 |           |                                                                    |

 |0.3MG/M3   |   100.0 100.0 100.0 100.0 100.0 100.0  92.0  84.0  76.0  52.0      |

 |STOP       |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.03         0.1MG/M3     0.3MG/M3 |

 |                                             MG/M3        STOP         STOP     |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       54.0%        58.0%        58.0%        52.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.817      P=0.570N     P=0.803N     P=1.000N |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       589.0        642.9        602.2        638.3    |

 |NATURAL DEATHS (C)      |       (26.9)       (21.6)       (20.3)       (14.2)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       666.8        695.1        678.1        687.5    |

 |(STANDARD ERROR)        |       (16.0)       (11.0)       (12.5)       ( 9.5)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 735 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      124   397   476   504   550   551   566   590   615   621                 |

 |      667   667   669   684   697   726                                         |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.03    MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 31        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      120   428   481   484   551   560   580   597   607   683                 |

 |      686   694   695   695   714   714   725   728                             |

 |  CENSORED DEATHS                                                               |

 |      26                                                                        |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      225   436   448   566   595   600   656   672   679   684                 |

 |      686   686   714   716                                                     |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 735 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 0.3MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      186   411   519   535   585   588   588   593   610   613                 |

 |      643   651   656   656   726   727                                         |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   735 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0  98.0  98.0  98.0  96.0  94.0  92.0  84.0  80.0  68.0      |

 |           |                                                                    |

 |           |                                                                    |

 |0.03       |   100.0  98.0  98.0  98.0  98.0  91.8  91.8  83.7  81.6  63.3      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.1MG/M3   |   100.0 100.0  98.0  98.0  98.0  94.0  94.0  88.0  86.0  72.0      |

 |STOP       |                                                                    |

 |           |                                                                    |

 |0.3MG/M3   |   100.0 100.0  98.0  98.0  96.0  96.0  92.0  84.0  72.0  68.0      |

 |STOP       |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.03         0.1MG/M3     0.3MG/M3 |

 |                                             MG/M3        STOP         STOP     |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       68.0%        63.3%        72.0%        68.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.959N     P=0.850      P=0.726N     P=1.000  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       569.0        596.8        597.4        580.4    |

 |NATURAL DEATHS (C)      |       (37.1)       (35.7)       (37.4)       (32.6)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       681.9        671.1        696.5        685.5    |

 |(STANDARD ERROR)        |       (16.0)       (20.5)       (13.5)       (14.5)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          INDIUM PHOSPHIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.03    MG/M3    = 2

                                                        0.1MG/M3 STOP    = 3

                                                        0.3MG/M3 STOP    = 4



------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

  100 + 1                     1                      2                  3                  4

      |

      |                       1                      2                  31   3             42

      |                                                                  1   3   3 1        2     2

   95 +

      |                                                                          3 1  1     4 4   22

      |                                                                               1  3 1  44   22

      |

   90 +                                                                                  3 1 1 44   2      2

      |

      |                                                                                      1 1           22

      |                                                                                        34      34   22

P  85 +

E     |                                                                                        1  1    34 43 2 2

R     |                                                                                           1    1  43 3 2    2

C     |

E  80 +                                                                                                1  1

N     |

T     |                                                                                                   11 33

      |                                                                                                    1 1 4  4

S  75 +

U     |                                                                                                      113    2 2

R     |

V     |

I  70 +                                                                                                       11 344  22

V     |

A     |                                                                                                        1 31

L     |                                                                                                           334

   65 +

      |                                                                                                           13  122

      |                                                                                                             4 4

      |

   60 +                                                                                                               112 2

      |

      |                                                                                                                11 2 2

      |

   55 +

      |                                                                                                                 1 4 1

      |                                                                                                                     4

      |

   50 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 24 obs hidden.
                                                          INDIUM PHOSPHIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.03    MG/M3    = 2

                                                        0.1MG/M3 STOP    = 3

                                                        0.3MG/M3 STOP    = 4



----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                   1         4     3

      |

      |                     1         4     3                          1 4  23

      |                                                                1 4  233    12      4

   95 +

      |                                                                       3    122 1   4 4   3

      |                                                                                1     4 1 3  4 3

      |                                                                              2         2

P  90 +                                                                                        22     33

E     |

R     |                                                                                        121 2   3       3

C     |                                                                                          1 24 12       3  3

E  85 +

N     |                                                                                               1221        33

T     |                                                                                                  11        33

      |                                                                                                 2           2

S  80 +                                                                                                  41  4    1

U     |

R     |                                                                                                      44     2 2

V     |                                                                                                       44    3   3

I  75 +

V     |                                                                                                           1 1   33

A     |                                                                                                        4    1 1  34 3

L     |                                                                                                               2 2

   70 +                                                                                                               1   1

      |

      |                                                                                                                 2 1 1

      |

   65 +

      |                                                                                                                   2 2

      |

      |

   60 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 11 obs hidden.

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