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TDMS Study 88124-04 Pathology Tables

NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:10:48

                                                     FINAL#2,  14 WEEK SSAC




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  10/02/98

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:10:48  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     


  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 (10%)      2 (20%)      3 (30%)                               
      Necrosis                                                      1 (10%)                   1 (10%)                               
      Oval Cell, Hyperplasia                                                     1 (10%)      2 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                   (10)                                   
      Cardiomyopathy                                   5 (50%)                                7 (70%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (9)          (8)          (10)         (10)                                   
      Foreign Body                                                  4 (50%)      9 (90%)     10 (100%)                              
      Hyperplasia                                      1 (11%)      5 (63%)     10 (100%)    10 (100%)                              
   Lymph Node, Mandibular                             (7)                                    (8)                                    
      Hyperplasia                                      1 (14%)                                                                      
   Lymph Node, Mediastinal                            (4)          (5)          (6)          (6)                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:10:48  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                                                4 (67%)      3 (50%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 4 (40%)      9 (90%)     10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)                                   (10)                                   
      Inflammation, Suppurative                        1 (10%)                                                                      
      Squamous Epithelium, Hyperplasia                 2 (20%)                                3 (30%)                               
   Lung                                               (10)         (10)         (10)         (10)                                   
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)                              
      Inflammation, Chronic Active                                  9 (90%)      9 (90%)      9 (90%)                               
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Lacrimal Gland                                     (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                   (10)                                   
      Nephropathy                                      1 (10%)                                4 (40%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:10:48  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     


  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                      (4)          (10)                                   
      Necrosis                                         1 (10%)                                1 (10%)                               
      Oval Cell, Hyperplasia                           1 (10%)                                1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                   (10)                                   
      Cardiomyopathy                                   5 (50%)                                8 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (10)                                   (10)                                   
      Atrophy                                          1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (9)          (10)         (10)         (10)                                   
      Foreign Body                                                  8 (80%)      9 (90%)     10 (100%)                              
      Hyperplasia                                                   8 (80%)     10 (100%)    10 (100%)                              
   Lymph Node, Mediastinal                            (6)          (6)          (9)          (6)                                    
      Hyperplasia                                                   3 (50%)      4 (44%)      6 (100%)                              
   Spleen                                             (10)         (10)         (10)         (10)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:10:48  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                              4 (40%)      5 (50%)      9 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)                      (4)          (10)                                   
      Inflammation, Suppurative                                                  1 (25%)      1 (10%)                               
      Squamous Epithelium, Hyperplasia                 2 (20%)                   1 (25%)      1 (10%)                               
   Lung                                               (10)         (10)         (10)         (10)                                   
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)                              
      Inflammation, Chronic Active                                  6 (60%)     10 (100%)    10 (100%)                              
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                   (10)                                   
      Nephropathy                                      1 (10%)                                1 (10%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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