TDMS Study 88124-04 Pathology Tables
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:10:48
FINAL#2, 14 WEEK SSAC
Facility: Battelle Northwest
Chemical CAS #: 22398-80-7
Lock Date: 10/02/98
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:10:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 2 (20%) 3 (30%)
Necrosis 1 (10%) 1 (10%)
Oval Cell, Hyperplasia 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 5 (50%) 7 (70%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (9) (8) (10) (10)
Foreign Body 4 (50%) 9 (90%) 10 (100%)
Hyperplasia 1 (11%) 5 (63%) 10 (100%) 10 (100%)
Lymph Node, Mandibular (7) (8)
Hyperplasia 1 (14%)
Lymph Node, Mediastinal (4) (5) (6) (6)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:10:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia 4 (67%) 3 (50%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 4 (40%) 9 (90%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (10)
Inflammation, Suppurative 1 (10%)
Squamous Epithelium, Hyperplasia 2 (20%) 3 (30%)
Lung (10) (10) (10) (10)
Foreign Body 10 (100%) 10 (100%) 10 (100%)
Inflammation, Chronic Active 9 (90%) 9 (90%) 9 (90%)
Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Lacrimal Gland (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Nephropathy 1 (10%) 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:10:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (4) (10)
Necrosis 1 (10%) 1 (10%)
Oval Cell, Hyperplasia 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 5 (50%) 8 (80%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (10) (10)
Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (9) (10) (10) (10)
Foreign Body 8 (80%) 9 (90%) 10 (100%)
Hyperplasia 8 (80%) 10 (100%) 10 (100%)
Lymph Node, Mediastinal (6) (6) (9) (6)
Hyperplasia 3 (50%) 4 (44%) 6 (100%)
Spleen (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 88124-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC INDIUM PHOSPHIDE Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:10:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.03 0.1MG/M3 0.3MG/M3
MG/M3 STOP STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 4 (40%) 5 (50%) 9 (90%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (10) (4) (10)
Inflammation, Suppurative 1 (25%) 1 (10%)
Squamous Epithelium, Hyperplasia 2 (20%) 1 (25%) 1 (10%)
Lung (10) (10) (10) (10)
Foreign Body 10 (100%) 10 (100%) 10 (100%)
Inflammation, Chronic Active 6 (60%) 10 (100%) 10 (100%)
Alveolus, Proteinosis 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Nephropathy 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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