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TDMS Study 88124-04 Pathology Tables

NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14

                                                    FINAL#2,  2 YEAR CHRONIC




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  10/02/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Accidently Killed                                  1                                      1                                     
    Moribund Sacrifice                                 4           31           15           18                                     
    Natural Death                                      3            6            2           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           13           33           21                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (45)         (48)         (43)                                   
      Degeneration, Hyaline                                         1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)       2 (4%)       3 (6%)                                             
   Intestine Large, Rectum                            (47)         (49)         (50)         (49)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (49)         (49)         (44)                                   
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Small, Ileum                             (46)         (48)         (50)         (48)                                   
      Epithelium, Hyperplasia                          1 (2%)       1 (2%)       1 (2%)                                             
      Peyer's Patch, Hyperplasia                       2 (4%)                                 1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)       2 (4%)                                
      Basophilic Focus                                 2 (4%)       2 (4%)                    2 (4%)                                
      Clear Cell Focus                                 2 (4%)                                 2 (4%)                                
      Eosinophilic Focus                               6 (12%)      5 (10%)      4 (8%)      10 (20%)                               
      Eosinophilic Focus, Multiple                                  4 (8%)                    2 (4%)                                
      Hematopoietic Cell Proliferation                 3 (6%)       3 (6%)       4 (8%)       3 (6%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation                                                  1 (2%)       1 (2%)                                             
      Karyomegaly                                      1 (2%)                                                                       
      Necrosis                                         4 (8%)       3 (6%)       9 (18%)      3 (6%)                                
      Tension Lipidosis                                2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Vacuolization Cytoplasmic                        1 (2%)                    1 (2%)                                             
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Bile Duct, Degeneration, Hyaline                                                        1 (2%)                                
   Mesentery                                          (13)         (8)          (8)          (4)                                    
      Angiectasis                                      1 (8%)                                                                       
      Artery, Inflammation                                          4 (50%)      2 (25%)      1 (25%)                               
      Fat, Necrosis                                   10 (77%)      3 (38%)      6 (75%)      3 (75%)                               
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Atrophy                                          1 (2%)                    1 (2%)       2 (4%)                                
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Inflammation                                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Erosion                                                                    2 (4%)                                             
      Foreign Body                                                                            1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Ulcer                                                         2 (4%)                                                          
      Epithelium, Hyperplasia                          1 (2%)       4 (8%)       4 (8%)       3 (6%)                                
   Stomach, Glandular                                 (49)         (49)         (50)         (49)                                   
      Inflammation, Suppurative                        2 (4%)                    1 (2%)       1 (2%)                                
      Necrosis, Focal                                                                         1 (2%)                                
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Tooth                                              (1)                       (2)                                                 
      Inflammation                                                               2 (100%)                                           
      Malformation                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  45 (90%)     39 (78%)     46 (92%)     38 (76%)                               
      Mineralization                                                             2 (4%)                                             
      Necrosis                                                                                1 (2%)                                
      Artery, Inflammation                             1 (2%)      16 (32%)     11 (22%)     13 (26%)                               
      Atrium, Thrombosis                               1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Epicardium, Inflammation                         1 (2%)       5 (10%)                   7 (14%)                               
      Pericardium, Inflammation                                     9 (18%)                   4 (8%)                                
      Valve, Inflammation                                                        1 (2%)                                             
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               2 (4%)       1 (2%)                    2 (4%)                                
      Degeneration, Cystic                             1 (2%)                    1 (2%)                                             
      Degeneration, Focal                                                                     1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Hypertrophy                                      9 (18%)      7 (14%)      3 (6%)      10 (20%)                               
      Capsule, Hyperplasia                                          1 (2%)                                                          
   Adrenal Medulla                                    (49)         (49)         (50)         (49)                                   
      Hyperplasia                                      4 (8%)       5 (10%)      2 (4%)       3 (6%)                                
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)                    2 (4%)       1 (2%)                                
   Parathyroid Gland                                  (34)         (31)         (29)         (30)                                   
      Hyperplasia                                      1 (3%)                                                                       
   Pituitary Gland                                    (50)         (50)         (48)         (49)                                   
      Pars Distalis, Hyperplasia                      16 (32%)     15 (30%)     21 (44%)     15 (31%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (50)         (49)                                   
      Inflammation, Suppurative                                     2 (4%)       4 (8%)       1 (2%)                                
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (46)         (44)         (47)                                   
      Angiectasis                                      2 (4%)       2 (4%)                    1 (2%)                                
      Cyst                                            12 (26%)      9 (20%)     11 (25%)      9 (19%)                               
      Thrombosis                                                    1 (2%)       1 (2%)       2 (4%)                                
      Interstitial Cell, Hyperplasia                   1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Uterus                                             (50)         (49)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       3 (6%)       3 (6%)       5 (10%)                               
      Hydrometra                                       8 (16%)      8 (16%)      8 (16%)      5 (10%)                               
      Hyperplasia, Cystic                             38 (76%)     31 (63%)     36 (72%)     32 (64%)                               
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                                                 1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                         2 (4%)                    1 (2%)                                             
      Hyperplasia                                      6 (12%)     13 (26%)      5 (10%)      7 (14%)                               
   Lymph Node                                         (1)          (5)          (6)          (8)                                    
      Iliac, Angiectasis                                            1 (20%)                                                         
      Iliac, Hematopoietic Cell Proliferation                                                 1 (13%)                               
      Iliac, Hyperplasia                                            1 (20%)                   1 (13%)                               
      Lumbar, Angiectasis                                                        1 (17%)                                            
      Lumbar, Hemorrhage                                                         1 (17%)                                            
      Lumbar, Hyperplasia                                           1 (20%)                   1 (13%)                               
      Lumbar, Inflammation, Chronic                                              1 (17%)                                            
      Renal, Angiectasis                                                         1 (17%)                                            
   Lymph Node, Bronchial                              (36)         (50)         (48)         (50)                                   
      Foreign Body                                                 44 (88%)     33 (69%)     40 (80%)                               
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                      5 (14%)     42 (84%)     31 (65%)     28 (56%)                               
      Artery, Inflammation                                          2 (4%)       1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                             (36)         (36)         (43)         (42)                                   
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
   Lymph Node, Mesenteric                             (48)         (49)         (50)         (48)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                
      Hyperplasia                                      8 (17%)      6 (12%)      7 (14%)      7 (15%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Lymph Node, Mediastinal                            (42)         (48)         (46)         (49)                                   
      Foreign Body                                                 20 (42%)      7 (15%)     16 (33%)                               
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                      2 (5%)      40 (83%)     11 (24%)     29 (59%)                               
   Spleen                                             (50)         (49)         (50)         (49)                                   
      Hematopoietic Cell Proliferation                16 (32%)     36 (73%)     26 (52%)     21 (43%)                               
      Hyperplasia, Lymphoid                           15 (30%)      3 (6%)      11 (22%)     14 (29%)                               
      Metaplasia, Osseous                                                        1 (2%)                                             
   Thymus                                             (47)         (46)         (42)         (42)                                   
      Hyperplasia, Lymphoid                                         3 (7%)       3 (7%)       2 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       4 (8%)       3 (6%)                                
      Metaplasia, Squamous                                          1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Suppurative                                     2 (4%)                    1 (2%)                                
      Hair Follicle, Atrophy                                                                  1 (2%)                                
      Subcutaneous Tissue, Angiectasis                              1 (2%)                                                          
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cyst                                                          1 (2%)                                                          
      Fibrous Osteodystrophy                          11 (22%)     14 (28%)     14 (28%)     16 (32%)                               
      Inflammation, Chronic                                         1 (2%)                                                          
      Maxilla, Fracture                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       2 (4%)                                
      Squamous Epithelium, Hyperplasia                 9 (18%)     17 (34%)     10 (20%)     15 (30%)                               
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                 49 (98%)     35 (70%)     49 (98%)                               
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hemorrhage                                       4 (8%)       3 (6%)       4 (8%)       4 (8%)                                
      Inflammation, Chronic Active                     2 (4%)      49 (98%)     45 (90%)     50 (100%)                              
      Thrombosis                                                                 1 (2%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                              1 (2%)       1 (2%)       2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte                   2 (4%)       2 (4%)       3 (6%)                                
      Alveolus, Proteinosis                                        31 (62%)                   8 (16%)                               
      Artery, Inflammation                                          1 (2%)       1 (2%)                                             
      Artery, Mediastinum, Inflammation                                          1 (2%)                                             
      Bronchiole, Bronchus, Degeneration, Hyaline                                             2 (4%)                                
      Interstitium, Fibrosis                                        1 (2%)                    2 (4%)                                
      Mediastinum, Inflammation, Chronic Active        1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                             1 (2%)                                                                       
      Serosa, Fibrosis                                             50 (100%)    47 (94%)     49 (98%)                               
      Serosa, Metaplasia, Osseous                                   1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Inflammation, Suppurative                        7 (14%)      7 (14%)      7 (14%)      2 (4%)                                
      Olfactory Epithelium, Atrophy                    6 (12%)      1 (2%)       3 (6%)       2 (4%)                                
      Olfactory Epithelium, Degeneration, Hyaline      3 (6%)       3 (6%)      10 (20%)      2 (4%)                                
      Respiratory Epithelium, Degeneration, Hyaline   28 (56%)     17 (34%)     27 (54%)     14 (28%)                               
      Respiratory Epithelium, Hyperplasia                                        1 (2%)                                             
   Pleura                                                          (16)         (3)          (13)                                   
      Mesothelium, Hyperplasia                                     16 (100%)     3 (100%)    13 (100%)                              
   Trachea                                            (50)         (48)         (50)         (50)                                   
      Degeneration, Hyaline                                                                   1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Degeneration                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Metaplasia, Osseous                              2 (4%)       3 (6%)       4 (8%)       2 (4%)                                
      Nephropathy                                     37 (74%)     30 (61%)     43 (86%)     36 (72%)                               
      Artery, Inflammation                                                       1 (2%)       3 (6%)                                
      Glomerulus, Inflammation, Chronic                                                       1 (2%)                                
      Renal Tubule, Karyomegaly                                                  1 (2%)                                             
   Urinary Bladder                                    (48)         (49)         (49)         (48)                                   
      Angiectasis                                      2 (4%)       1 (2%)       3 (6%)       2 (4%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                      8           11            9           11                                     
    Moribund Sacrifice                                 5           14           12           12                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           24           29           27                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (43)         (43)         (41)         (38)                                   
      Degeneration, Hyaline                                         1 (2%)                    2 (5%)                                
      Inflammation, Chronic                                                                   1 (3%)                                
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Intestine Large, Colon                             (49)         (48)         (48)         (46)                                   
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
   Intestine Large, Cecum                             (47)         (47)         (46)         (46)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (44)         (46)         (44)                                   
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Ileum                             (45)         (47)         (43)         (45)                                   
      Amyloid Deposition                                            1 (2%)                                                          
      Artery, Inflammation                                                       1 (2%)                                             
      Epithelium, Hyperplasia                                                                 1 (2%)                                
      Peyer's Patch, Hyperplasia                       5 (11%)                                1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                            2 (4%)                                                          
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                 2 (4%)       1 (2%)       2 (4%)                                             
      Clear Cell Focus                                 1 (2%)       1 (2%)                                                          
      Clear Cell Focus, Multiple                       1 (2%)                    2 (4%)                                             
      Eosinophilic Focus                               9 (18%)     15 (30%)     14 (28%)     10 (20%)                               
      Eosinophilic Focus, Multiple                     1 (2%)       1 (2%)       5 (10%)      8 (16%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Focal, Granulomatous               1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                                           1 (2%)       1 (2%)                                
      Necrosis                                         4 (8%)       4 (8%)       2 (4%)       7 (14%)                               
      Tension Lipidosis                                2 (4%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                        2 (4%)                    1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (4)          (5)          (5)          (8)                                    
      Artery, Inflammation                                          4 (80%)      1 (20%)      1 (13%)                               
      Fat, Inflammation                                                                       1 (13%)                               
      Fat, Necrosis                                    4 (100%)     1 (20%)      4 (80%)      4 (50%)                               
   Pancreas                                           (50)         (50)         (49)         (47)                                   
      Atrophy                                          3 (6%)                    2 (4%)       2 (4%)                                
      Hypertrophy                                                                             2 (4%)                                
      Artery, Inflammation                                                       1 (2%)                                             
      Duct, Cyst                                       1 (2%)                                 1 (2%)                                
   Stomach, Forestomach                               (49)         (50)         (48)         (50)                                   
      Erosion                                                                                 2 (4%)                                
      Infiltration Cellular                                                      1 (2%)                                             
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Artery, Inflammation                                          1 (2%)                                                          
      Epithelium, Hyperplasia                          2 (4%)       6 (12%)      8 (17%)      5 (10%)                               
   Stomach, Glandular                                 (49)         (49)         (48)         (47)                                   
      Infiltration Cellular                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    2 (4%)       2 (4%)                                
      Necrosis, Focal                                  1 (2%)                    1 (2%)       1 (2%)                                
      Epithelium, Hyperplasia                          1 (2%)                    1 (2%)                                             
   Tooth                                                           (2)          (1)          (2)                                    
      Inflammation                                                  2 (100%)     1 (100%)                                           
      Malformation                                                                            2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (2)          (1)                                                 
      Inflammation                                                               1 (100%)                                           
      Mineralization                                   1 (100%)                                                                     
      Aorta, Aneurysm                                               1 (50%)                                                         
      Aorta, Hemorrhage                                             1 (50%)                                                         
      Aorta, Inflammation                                           1 (50%)                                                         
      Aorta, Mineralization                                         1 (50%)                                                         
      Aorta, Necrosis                                               1 (50%)                                                         
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  39 (78%)     41 (82%)     42 (84%)     41 (82%)                               
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization                                                             2 (4%)       1 (2%)                                
      Artery, Inflammation                             3 (6%)      18 (36%)     14 (28%)     10 (20%)                               
      Artery, Mineralization                           1 (2%)                                                                       
      Atrium, Inflammation, Chronic                                 1 (2%)                    1 (2%)                                
      Atrium, Metaplasia, Osseous                                                             1 (2%)                                
      Atrium, Thrombosis                                            1 (2%)                    2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Epicardium, Inflammation                                      2 (4%)       1 (2%)                                             
      Pericardium, Inflammation                                     6 (12%)                   5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (48)         (50)                                   
      Amyloid Deposition                                            2 (4%)                                                          
      Angiectasis                                                   1 (2%)                                                          
      Degeneration, Focal                                           1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Hypertrophy                                     30 (60%)     15 (30%)     23 (48%)     19 (38%)                               
      Necrosis                                                      1 (2%)                                                          
   Adrenal Medulla                                    (50)         (50)         (48)         (49)                                   
      Hyperplasia                                      3 (6%)       2 (4%)       1 (2%)       6 (12%)                               
   Islets, Pancreatic                                 (50)         (50)         (49)         (47)                                   
      Hyperplasia                                      8 (16%)      1 (2%)       3 (6%)       4 (9%)                                
   Parathyroid Gland                                  (33)         (30)         (34)         (34)                                   
      Amyloid Deposition                                            1 (3%)                                                          
   Pituitary Gland                                    (48)         (47)         (45)         (50)                                   
      Pars Distalis, Hyperplasia                                    1 (2%)       1 (2%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)       1 (2%)                                
   Thyroid Gland                                      (47)         (48)         (47)         (50)                                   
      Amyloid Deposition                                            2 (4%)                                                          
      Follicle, Degeneration, Cystic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  2 (4%)                                 2 (4%)                                
      Inflammation                                     1 (2%)                    1 (2%)       2 (4%)                                
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Ectasia                                         25 (50%)     21 (42%)     19 (38%)     20 (41%)                               
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation                                     5 (10%)                   3 (6%)                                             
   Prostate                                           (50)         (49)         (48)         (48)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
   Seminal Vesicle                                    (49)         (47)         (48)         (47)                                   
      Congestion                                                                              1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                          6 (12%)      1 (2%)       2 (4%)       2 (4%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Interstitial Cell, Hyperplasia                                             1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      5 (10%)      9 (18%)      6 (12%)      4 (8%)                                
   Lymph Node, Bronchial                              (35)         (48)         (45)         (48)                                   
      Foreign Body                                                 43 (90%)     40 (89%)     40 (83%)                               
      Hyperplasia                                      2 (6%)      36 (75%)     22 (49%)     22 (46%)                               
      Artery, Inflammation                                                                    1 (2%)                                
   Lymph Node, Mandibular                             (28)         (32)         (33)         (36)                                   
      Hyperplasia                                      1 (4%)       2 (6%)       1 (3%)                                             
   Lymph Node, Mesenteric                             (48)         (47)         (49)         (45)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                     11 (23%)      2 (4%)      10 (20%)     10 (22%)                               
      Inflammation, Granulomatous                      2 (4%)                                                                       
      Artery, Inflammation                             1 (2%)                                                                       
   Lymph Node, Mediastinal                            (40)         (49)         (45)         (48)                                   
      Foreign Body                                                 24 (49%)     14 (31%)     25 (52%)                               
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                                
      Hyperplasia                                                  34 (69%)     17 (38%)     27 (56%)                               
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Artery, Inflammation                                          1 (2%)       2 (4%)       1 (2%)                                
   Spleen                                             (50)         (50)         (48)         (48)                                   
      Amyloid Deposition                                            2 (4%)                                                          
      Angiectasis                                      2 (4%)       2 (4%)                                                          
      Hematopoietic Cell Proliferation                14 (28%)     34 (68%)     23 (48%)     29 (60%)                               
      Hyperplasia, Lymphoid                                         3 (6%)       4 (8%)       3 (6%)                                
   Thymus                                             (35)         (39)         (41)         (35)                                   
      Epithelial Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       2 (4%)                                             
      Inflammation, Suppurative                                     1 (2%)       3 (6%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Prepuce, Inflammation, Chronic Active            1 (2%)       2 (4%)       3 (6%)       3 (6%)                                
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (49)         (50)         (50)                                   
      Fibrous Osteodystrophy                           2 (4%)                    2 (4%)       2 (4%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Maxilla, Fracture                                             1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Degeneration                                                               1 (2%)                                             
      Developmental Malformation                                                              1 (2%)                                
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                                   2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (50)                                   
      Inflammation, Suppurative                        5 (10%)      3 (6%)       1 (2%)       4 (8%)                                
      Epiglottis, Metaplasia, Squamous                 1 (2%)                                                                       
      Squamous Epithelium, Hyperplasia                 6 (12%)      3 (6%)       4 (8%)       7 (14%)                               
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                 49 (98%)     42 (84%)     49 (98%)                               
      Hemorrhage                                       5 (10%)      1 (2%)       2 (4%)       2 (4%)                                
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)      50 (100%)    45 (90%)     46 (92%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)       5 (10%)      3 (6%)       7 (14%)                               
      Alveolus, Infiltration Cellular, Histiocyte                   1 (2%)                                                          
      Alveolus, Proteinosis                                        14 (28%)                  10 (20%)                               
      Artery, Mediastinum, Inflammation                             2 (4%)       2 (4%)                                             
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
      Interstitium, Fibrosis                                        2 (4%)                                                          
      Serosa, Cyst                                                               1 (2%)                                             
      Serosa, Fibrosis                                             50 (100%)    49 (98%)     50 (100%)                              
      Serosa, Metaplasia, Osseous                                                             1 (2%)                                
   Nose                                               (49)         (50)         (49)         (50)                                   
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Suppurative                        3 (6%)       5 (10%)      4 (8%)       5 (10%)                               
      Olfactory Epithelium, Atrophy                    2 (4%)       4 (8%)       2 (4%)       1 (2%)                                
      Olfactory Epithelium, Degeneration, Hyaline      1 (2%)                                                                       
      Respiratory Epithelium, Degeneration, Hyaline    5 (10%)      2 (4%)       3 (6%)       4 (8%)                                
   Pleura                                                          (19)         (4)          (6)                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:17:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mesothelium, Hyperplasia                                     19 (100%)     4 (100%)     6 (100%)                              
   Trachea                                            (48)         (46)         (48)         (47)                                   
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (3)          (1)                                    
      Degeneration                                                  1 (100%)     2 (67%)                                            
      Cornea, Inflammation                                                       1 (33%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Amyloid Deposition                                            2 (4%)                    2 (4%)                                
      Cyst                                             2 (4%)       1 (2%)                                                          
      Infiltration Cellular, Focal, Mixed Cell                      1 (2%)                                                          
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
      Inflammation, Chronic Active                                                            2 (4%)                                
      Metaplasia, Osseous                              5 (10%)                   2 (4%)       1 (2%)                                
      Nephropathy                                     47 (94%)     40 (80%)     41 (84%)     41 (82%)                               
      Artery, Inflammation                                          5 (10%)      6 (12%)      2 (4%)                                
      Capsule, Hemorrhage                                                        2 (4%)                                             
      Capsule, Inflammation, Chronic                                                          1 (2%)                                
      Glomerulus, Inflammation, Chronic                1 (2%)       1 (2%)                                                          
      Renal Tubule, Hyperplasia                        5 (10%)      2 (4%)       3 (6%)       5 (10%)                               
   Urinary Bladder                                    (50)         (50)         (48)         (47)                                   
      Angiectasis                                                   1 (2%)                                                          
      Degeneration                                                                            1 (2%)                                
      Inflammation                                                                            1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

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