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TDMS Study 88124-04 Pathology Tables

NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56

                                                  FINAL#2, 2 YEAR CHRONIC MICE




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  10/02/98

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Accidently Killed                                  1                                      1                                     
    Moribund Sacrifice                                 4           31           15           18                                     
    Natural Death                                      3            6            2           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           13           33           21                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (47)         (50)         (48)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (49)         (49)         (44)                                   
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Hepatoblastoma                                                                          1 (2%)                                
      Hepatocellular Carcinoma                         4 (8%)      13 (26%)      7 (14%)      8 (16%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)       4 (8%)       1 (2%)       2 (4%)                                
      Hepatocellular Adenoma                          12 (24%)      6 (12%)     12 (24%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                              8 (16%)      6 (12%)      4 (8%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       2 (4%)                                
   Mesentery                                          (13)         (8)          (8)          (4)                                    
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (13%)                                                         
      Sarcoma                                          1 (8%)                                                                       
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (49)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Capsule, Adenoma                                                                        1 (2%)                                
   Adrenal Medulla                                    (49)         (49)         (50)         (49)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Pheochromocytoma Benign                          2 (4%)                    2 (4%)                                             
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Adenoma                                                                    2 (4%)                                             
   Pituitary Gland                                    (50)         (50)         (48)         (49)                                   
      Carcinoma                                                                               1 (2%)                                
      Pars Distalis, Adenoma                          10 (20%)      7 (14%)     11 (23%)      7 (14%)                               
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                                      1 (2%)                    1 (2%)                                
   Thyroid Gland                                      (50)         (49)         (50)         (49)                                   
      Bilateral, Follicular Cell, Adenoma                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (47)         (46)         (44)         (47)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Cystadenoma                                                                             1 (2%)                                
      Granulosa Cell Tumor Benign                                                2 (5%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Teratoma Malignant                                                                      1 (2%)                                
   Uterus                                             (50)         (49)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Polyp Stromal                                                 1 (2%)       1 (2%)       2 (4%)                                
      Polyp Stromal, Multiple                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Lymph Node                                         (1)          (5)          (6)          (8)                                    
      Renal, Histiocytic Sarcoma                                    1 (20%)                   1 (13%)                               
   Lymph Node, Bronchial                              (36)         (50)         (48)         (50)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)       2 (4%)                                
   Lymph Node, Mandibular                             (36)         (36)         (43)         (42)                                   
      Histiocytic Sarcoma                                           1 (3%)       1 (2%)       1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (49)         (50)         (48)                                   
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)       2 (4%)                                
   Lymph Node, Mediastinal                            (42)         (48)         (46)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Spleen                                             (50)         (49)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)       2 (4%)       1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
   Thymus                                             (47)         (46)         (42)         (42)                                   
      Histiocytic Sarcoma                                           2 (4%)                    2 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             2 (4%)       2 (4%)                                                          
      Subcutaneous Tissue, Sarcoma                                               1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
   Skeletal Muscle                                                                           (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Spinal Cord                                        (1)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       6 (12%)      9 (18%)      5 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       5 (10%)      5 (10%)      7 (14%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   2 (4%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                    2 (4%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)       1 (2%)                                
      Mediastinum, Carcinoma, Metastatic,                                                                                           
          Uncertain Primary Site                                    1 (2%)                                                          
      Mediastinum, Hemangioma                                                    1 (2%)                                             
      Mediastinum, Histiocytic Sarcoma                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)                       (2)          (2)                                    
      Adenoma                                          2 (67%)                   2 (100%)     2 (100%)                              
      Adenoma, Multiple                                1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                    1 (2%)                                
   Urinary Bladder                                    (48)         (49)         (49)         (48)                                   
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
      Lymphoma Malignant                               8 (16%)      4 (8%)      10 (20%)     13 (26%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   6                                                               
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          37          45          40                                       
     Total Primary Neoplasms                           56          65          80          74                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          24          36          26                                       
     Total Benign Neoplasms                            31          29          52          35                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          25          25          27                                       
     Total Malignant Neoplasms                         25          36          28          39                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           5           3                                       
     Total Metastatic Neoplasm                          1           6          11           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                      8           11            9           11                                     
    Moribund Sacrifice                                 5           14           12           12                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           24           29           27                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (43)         (43)         (42)         (44)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (44)         (46)         (44)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)       3 (7%)       2 (5%)                                
      Peyer's Patch, Histiocytic Sarcoma                            1 (2%)                                                          
   Intestine Small, Ileum                             (45)         (47)         (43)         (45)                                   
      Carcinoma                                                                  2 (5%)       1 (2%)                                
      Peyer's Patch, Histiocytic Sarcoma                            1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                             1 (2%)                                
      Hemangiosarcoma                                  2 (4%)       1 (2%)                    2 (4%)                                
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                        10 (20%)     15 (30%)     13 (26%)     11 (22%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       7 (14%)     10 (20%)      5 (10%)                               
      Hepatocellular Adenoma                           9 (18%)     11 (22%)     13 (26%)     18 (36%)                               
      Hepatocellular Adenoma, Multiple                 8 (16%)     13 (26%)     10 (20%)     14 (28%)                               
      Hepatocholangiocarcinoma                                                                1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Mesentery                                          (4)          (5)          (5)          (8)                                    
      Fat, Carcinoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                                                            1 (13%)                               
      Fat, Hepatocholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                              1 (13%)                               
   Pancreas                                           (50)         (50)         (49)         (47)                                   
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                             1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (48)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                          1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (48)         (50)                                   
      Adenoma                                          2 (4%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Capsule, Adenoma                                                           1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (48)         (49)                                   
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (47)                                   
      Adenoma                                          2 (4%)                                                                       
      Adenoma, Multiple                                1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
   Pituitary Gland                                    (48)         (47)         (45)         (50)                                   
      Pars Intermedia, Adenoma                                                   2 (4%)       1 (2%)                                
   Thyroid Gland                                      (47)         (48)         (47)         (50)                                   
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
   Prostate                                           (50)         (49)         (48)         (48)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                       2 (4%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
   Lymph Node                                         (1)          (1)          (1)          (2)                                    
      Pancreatic, Histiocytic Sarcoma                               1 (100%)                                                        
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Bronchial                              (35)         (48)         (45)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mandibular                             (28)         (32)         (33)         (36)                                   
      Histiocytic Sarcoma                                           1 (3%)                                                          
   Lymph Node, Mesenteric                             (48)         (47)         (49)         (45)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mediastinal                            (40)         (49)         (45)         (48)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (3%)                    2 (4%)       1 (2%)                                
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                                             1 (2%)                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
   Spleen                                             (50)         (50)         (48)         (48)                                   
      Hemangiosarcoma                                  2 (4%)                    1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (35)         (39)         (41)         (35)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (3%)                    1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (3%)                                
      Histiocytic Sarcoma                                           1 (3%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (49)         (50)         (50)                                   
      Oligodendroglioma Malignant, Metastatic,                                                                                      
           Brain                                       1 (2%)                                                                       
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                                              (1)          (2)                                    
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (50%)                               
      Sarcoma                                                                    1 (100%)     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    12 (24%)      7 (14%)      7 (14%)     10 (20%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       2 (4%)                    3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   5 (10%)      7 (14%)     19 (38%)      9 (18%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       8 (16%)      3 (6%)       4 (8%)                                
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       1 (2%)       6 (12%)      4 (8%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                    2 (4%)       1 (2%)                                
      Mediastinum, Carcinoma, Metastatic,                                                                                           
          Harderian Gland                                           1 (2%)                                                          
      Mediastinum, Hemangioma                                                    1 (2%)                                             
      Mediastinum, Hemangiosarcoma                                  1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Skeletal                                                                                    
          Muscle                                                                 1 (2%)                                             
   Nose                                               (49)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (1)          (3)          (2)                                    
      Adenoma                                          1 (100%)                  2 (67%)      1 (50%)                               
      Adenoma, Multiple                                                                       1 (50%)                               
      Carcinoma                                                     1 (100%)     1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (48)         (47)                                   
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)                    1 (2%)                                
      Lymphoma Malignant                               1 (2%)       1 (2%)       3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  12                                                               
NTP Experiment-Test: 88124-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          INDIUM PHOSPHIDE                                     Date: 02/24/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:06:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.03         0.1MG/M3     0.3MG/M3                                  
                                                                MG/M3         STOP         STOP                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          45          46          45                                       
     Total Primary Neoplasms                           66          83          98          90                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          27          31          35                                       
     Total Benign Neoplasms                            40          36          42          49                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          35          40          30                                       
     Total Malignant Neoplasms                         26          47          56          41                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           3          10           7                                       
     Total Metastatic Neoplasm                          8           4          16          20                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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