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TDMS Study 88124-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00       
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:29:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              FINAL#2,                                                              
                                                                                                                                    

               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00     
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:29:39     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 INDIUM PHOSPHIDE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hypertrophy
Heart                                  Cardiomyopathy
Heart: Artery                          Inflammation
Heart: Pericardium                     Inflammation
Intestine Small, Ileum: Peyer's Patch  Hyperplasia
Islets, Pancreatic                     Hyperplasia
Kidney                                 Inflammation Chronic
                                       Metaplasia Osseous
                                       Nephropathy
Kidney: Artery                         Inflammation
Larynx                                 Inflammation
Liver                                  Eosinophilic Focus
Lung                                   Foreign Body
                                       Inflammation Chronic
Lung: Alveolar Epithelium              Hyperplasia
Lung: Alveolus                         Proteinosis
Lung: Serosa                           Fibrosis
Lymph Node, Bronchial                  Foreign Body
                                       Hyperplasia
Lymph Node, Mediastinal                Foreign Body
                                       Hyperplasia
Lymph Node, Mesenteric                 Hyperplasia
Mesentery: Artery                      Inflammation
Mesentery: Fat                         Necrosis
Pancreas                               Hypertrophy
Preputial Gland                        Inflammation
Spleen                                 Hematopoietic Cell Proliferation
                                       Hyperplasia Lymphoid
Stomach, Forestomach                   Erosion
Stomach, Forestomach: Epithelium       Hyperplasia
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hypertrophy
Adrenal Medulla                        Hyperplasia
Bone                                   Fibrous Osteodystrophy
Bone Marrow                            Hyperplasia
Heart                                  Cardiomyopathy
Heart: Artery                          Inflammation
Heart: Epicardium                      Inflammation
Heart: Pericardium                     Inflammation
Kidney                                 Nephropathy
Kidney: Artery                         Inflammation
Larynx: Squamous Epithelium            Hyperplasia
Liver                                  Angiectasis
                                       Eosinophilic Focus
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00     
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:29:39     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7    

Lung                                   Foreign Body
                                       Inflammation Chronic
Lung: Alveolus                         Infiltration Cellular Histiocyte
                                       Proteinosis
Lung: Bronchiole, Bronchus             Degeneration Hyaline
Lung: Serosa                           Fibrosis
Lymph Node, Bronchial                  Foreign Body
                                       Hyperplasia
Lymph Node, Mediastinal                Foreign Body
                                       Hyperplasia
Mesentery: Artery                      Inflammation
Nose: Olfactory Epithelium             Degeneration Hyaline
Nose: Respiratory Epithelium           Degeneration Hyaline
Pituitary Gland: Pars Distalis         Hyperplasia
Spleen                                 Hematopoietic Cell Proliferation
                                       Hyperplasia Lymphoid
Thymus                                 Hyperplasia Lymphoid
Thyroid Gland                          Inflammation
Tooth                                  Malformation
Uterus                                 Angiectasis
                                       Hyperplasia Cystic
===============================================================
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Amyloid Deposition                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/48 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         0.0%        |4.3%         2.7%         0.0%         5.1%         |
|TERMINAL (d)       |     0/37 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |1/42 (2%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          562          ---          ---         |678          653          ---          594          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.385N     P=0.180      (e)          (e)         |P=0.436      P=0.731      P=0.274N     P=0.554      |
|POLY 3             |     P=0.407N     P=0.205      (e)          (e)         |P=0.495      P=0.580N     P=0.243N     P=0.623      |
|POLY 1.5           |     P=0.392N     P=0.217      (e)          (e)         |P=0.501      P=0.543N     P=0.239N     P=0.653      |
|POLY 6             |     P=0.423N     P=0.195      (e)          (e)         |P=0.488      P=0.635N     P=0.252N     P=0.584      |
|LOGISTIC REGRESSION|     P=0.361N     P=0.279      (e)          (e)         |P=0.562      P=0.516N     P=0.238N     P=0.647N     |
|COCH-ARM / FISHERS |     P=0.369N     P=0.247      (e)          (e)         |P=0.512      P=0.500N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/48 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.6%         4.9%         2.4%        |0.0%         0.0%         0.0%         2.6%         |
|TERMINAL (d)       |     1/37 (3%)    1/24 (4%)    2/29 (7%)    1/27 (4%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |---          ---          ---          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.610      P=0.662      P=0.415      P=0.690     |P=0.175      (e)          (e)          P=0.421      |
|POLY 3             |     P=0.638      P=0.723      P=0.459      P=0.736     |P=0.198      (e)          (e)          P=0.460      |
|POLY 1.5           |     P=0.647N     P=0.737      P=0.470      P=0.746     |P=0.204      (e)          (e)          P=0.476      |
|POLY 6             |     P=0.621      P=0.708      P=0.446      P=0.723     |P=0.190      (e)          (e)          P=0.439      |
|LOGISTIC REGRESSION|     P=0.610      P=0.662      P=0.415      P=0.690     |P=0.229      (e)          (e)          P=0.527      |
|COCH-ARM / FISHERS |     P=0.639N     P=0.753N     P=0.485      P=0.753N    |P=0.214      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  15/50 (30%)  23/48 (48%)  19/50 (38%) |9/50 (18%)   7/50 (14%)   3/50 (6%)    10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     63.3%        37.6%        55.5%        45.2%       |19.2%        18.8%        6.5%         25.7%        |
|TERMINAL (d)       |     25/37 (68%)  12/24 (50%)  20/29 (69%)  14/27 (52%) |9/42 (21%)   5/13 (39%)   2/33 (6%)    7/21 (33%)   |
|FIRST INCIDENCE    |     559          530          672          664         |735 (T)      687          685          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.406N     P=0.135N     P=0.527N     P=0.289N    |P=0.096      P=0.048 *    P=0.129N     P=0.055      |
|POLY 3             |     P=0.178N     P=0.011N*    P=0.290N     P=0.059N    |P=0.244      P=0.590N     P=0.063N     P=0.325      |
|POLY 1.5           |     P=0.161N     P=0.005N**   P=0.228N     P=0.038N*   |P=0.269      P=0.496N     P=0.060N     P=0.397      |
|POLY 6             |     P=0.217N     P=0.022N*    P=0.386N     P=0.098N    |P=0.212      P=0.486      P=0.070N     P=0.239      |
|LOGISTIC REGRESSION|     P=0.291N     P=0.025N*    P=0.376N     P=0.111N    |P=0.165      P=0.165      P=0.088N     P=0.251      |
|COCH-ARM / FISHERS |     P=0.162N     P=0.002N**   P=0.159N     P=0.022N*   |P=0.308      P=0.393N     P=0.061N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/48 (2%)    6/49 (12%)  |4/49 (8%)    5/49 (10%)   2/50 (4%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     6.4%         5.1%         2.4%         14.5%       |8.7%         13.6%        4.3%         7.9%         |
|TERMINAL (d)       |     2/37 (5%)    2/24 (8%)    0/29 (0%)    4/27 (15%)  |4/41 (10%)   3/13 (23%)   1/33 (3%)    2/21 (10%)   |
|FIRST INCIDENCE    |     559          733 (T)      672          562         |735 (T)      700          589          705          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.053      P=0.669N     P=0.374N     P=0.145     |P=0.532N     P=0.036 *    P=0.422N     P=0.470      |
|POLY 3             |     P=0.065      P=0.579N     P=0.351N     P=0.186     |P=0.423N     P=0.367      P=0.332N     P=0.603N     |
|POLY 1.5           |     P=0.067      P=0.550N     P=0.338N     P=0.204     |P=0.396N     P=0.429      P=0.328N     P=0.561N     |
|POLY 6             |     P=0.061      P=0.609N     P=0.366N     P=0.166     |P=0.460N     P=0.277      P=0.345N     P=0.646      |
|LOGISTIC REGRESSION|     P=0.068      P=0.541N     P=0.258N     P=0.272     |P=0.451N     P=0.111      P=0.328N     P=0.571      |
|COCH-ARM / FISHERS |     P=0.070      P=0.500N     P=0.324N     P=0.233     |P=0.357N     P=0.500      P=0.329N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    2/50 (4%)    2/50 (4%)   |11/50 (22%)  14/50 (28%)  14/50 (28%)  16/50 (32%)  |
|POLY-3 ADJUSTED (b)|     4.4%         0.0%         4.7%         4.8%        |23.5%        37.1%        30.4%        40.1%        |
|TERMINAL (d)       |     2/36 (6%)    0/23 (0%)    1/29 (3%)    2/27 (7%)   |11/42 (26%)  8/13 (62%)   13/33 (39%)  9/21 (43%)   |
|FIRST INCIDENCE    |     733 (T)      ---          678          733 (T)     |735 (T)      671          672          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.372      P=0.341N     P=0.617      P=0.588     |P=0.022 *    P<0.001 **   P=0.120      P=0.003 **   |
|POLY 3             |     P=0.431      P=0.276N     P=0.671      P=0.663     |P=0.110      P=0.130      P=0.303      P=0.074      |
|POLY 1.5           |     P=0.434      P=0.261N     P=0.683      P=0.678     |P=0.144      P=0.209      P=0.318      P=0.111      |
|POLY 6             |     P=0.422      P=0.292N     P=0.655      P=0.642     |P=0.072      P=0.054      P=0.271      P=0.041 *    |
|LOGISTIC REGRESSION|     P=0.391      (e)          P=0.654      P=0.588     |P=0.058      P=0.003 **   P=0.177      P=0.048 *    |
|COCH-ARM / FISHERS |     P=0.431      P=0.247N     P=0.684N     P=0.684N    |P=0.205      P=0.322      P=0.322      P=0.184      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/36 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |2/42 (5%)    0/13 (0%)    1/33 (3%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.345N     P=0.518N     P=0.584N     P=0.401N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.263N     P=0.294N     P=0.508N     P=0.287N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.268N     P=0.266N     P=0.502N     P=0.265N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.256N     P=0.339N     P=0.520N     P=0.316N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.345N     (e)          P=0.584N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.271N     P=0.247N     P=0.500N     P=0.247N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   9/50 (18%)   6/50 (12%)   4/50 (8%)   |6/50 (12%)   13/50 (26%)  5/50 (10%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     11.1%        21.5%        13.9%        9.5%        |12.8%        31.9%        10.9%        17.7%        |
|TERMINAL (d)       |     4/36 (11%)   3/24 (13%)   3/29 (10%)   2/27 (7%)   |5/42 (12%)   4/13 (31%)   4/33 (12%)   4/21 (19%)   |
|FIRST INCIDENCE    |     726          405          475          608         |678          426          681          493          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.305N     P=0.079      P=0.370      P=0.613     |P=0.543      P<0.001 **   P=0.608      P=0.144      |
|POLY 3             |     P=0.258N     P=0.151      P=0.468      P=0.544N    |P=0.471N     P=0.025 *    P=0.515N     P=0.369      |
|POLY 1.5           |     P=0.240N     P=0.170      P=0.487      P=0.522N    |P=0.417N     P=0.040 *    P=0.504N     P=0.423      |
|POLY 6             |     P=0.281N     P=0.133      P=0.443      P=0.570N    |P=0.546N     P=0.011 *    P=0.539N     P=0.302      |
|LOGISTIC REGRESSION|     P=0.205N     P=0.290      P=0.491      P=0.555N    |P=0.302N     P=0.098      P=0.531N     P=0.468      |
|COCH-ARM / FISHERS |     P=0.216N     P=0.205      P=0.514      P=0.487N    |P=0.343N     P=0.062      P=0.500N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain: Meninges                                                                                                                  |
|     Infiltration Cellular Mononuclear Cell                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.7%         0.0%        |4.3%         5.4%         4.3%         5.1%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    2/29 (7%)    0/27 (0%)   |2/42 (5%)    1/13 (8%)    1/33 (3%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          733 (T)      ---         |735 (T)      630          664          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.730N     (e)          P=0.186      (e)         |P=0.508      P=0.344      P=0.625      P=0.535      |
|POLY 3             |     P=0.713N     (e)          P=0.218      (e)         |P=0.571      P=0.609      P=0.688      P=0.627      |
|POLY 1.5           |     P=0.706N     (e)          P=0.226      (e)         |P=0.591      P=0.650      P=0.693      P=0.656      |
|POLY 6             |     P=0.723      (e)          P=0.207      (e)         |P=0.541      P=0.544      P=0.678      P=0.589      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.186      (e)         |P=0.577N     P=0.596      P=0.693      P=0.616N     |
|COCH-ARM / FISHERS |     P=0.697N     (e)          P=0.247      (e)         |P=0.621      P=0.691N     P=0.691N     P=0.691N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.3%         0.0%         0.0%         4.7%        |                                                    |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |                                                    |
|FIRST INCIDENCE    |     662          ---          ---          370         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.349      P=0.311N     P=0.288N     P=0.618     |                                                    |
|POLY 3             |     P=0.398      P=0.277N     P=0.259N     P=0.660     |                                                    |
|POLY 1.5           |     P=0.394      P=0.262N     P=0.250N     P=0.675     |                                                    |
|POLY 6             |     P=0.398      P=0.294N     P=0.272N     P=0.639     |                                                    |
|LOGISTIC REGRESSION|     P=0.395      P=0.243N     P=0.227N     P=0.504N    |                                                    |
|COCH-ARM / FISHERS |     P=0.381      P=0.247N     P=0.247N     P=0.691N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         2.4%         4.8%        |                                                    |
|TERMINAL (d)       |     1/37 (3%)    0/24 (0%)    0/29 (0%)    1/27 (4%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      ---          682          533         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.205      P=0.586N     P=0.701      P=0.420     |                                                    |
|POLY 3             |     P=0.233      P=0.532N     P=0.741      P=0.467     |                                                    |
|POLY 1.5           |     P=0.234      P=0.520N     P=0.749      P=0.481     |                                                    |
|POLY 6             |     P=0.228      P=0.544N     P=0.731      P=0.451     |                                                    |
|LOGISTIC REGRESSION|     P=0.235      (e)          P=0.752      P=0.570     |                                                    |
|COCH-ARM / FISHERS |     P=0.231      P=0.500N     P=0.753N     P=0.500     |                                                    |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     1/1 (100%)   2/3 (67%)    0/1 (0%)    |0/0 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       66.7%        0.0%        |0.0%         0.0%         100.0%       0.0%         |
|TERMINAL (d)       |     0/0 (0%)     1/1 (100%)   0/1 (0%)     0/1 (0%)    |0/0 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)     |
|FIRST INCIDENCE    |     ---          733 (T)      669          ---         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.472N     (e)          P=0.191      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.315N     (e)          P=1.000      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Gallbladder                                                                                                                      |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/43 (0%)    1/43 (2%)    0/41 (0%)    2/38 (5%)   |0/46 (0%)    1/45 (2%)    0/48 (0%)    0/43 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.9%         0.0%         6.0%        |0.0%         3.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    0/22 (0%)    0/28 (0%)    0/24 (0%)   |0/42 (0%)    0/12 (0%)    0/32 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          687          ---          664         |---          688          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.129      P=0.473      (e)          P=0.189     |P=0.612N     P=0.353      (e)          (e)          |
|POLY 3             |     P=0.117      P=0.465      (e)          P=0.194     |P=0.625N     P=0.446      (e)          (e)          |
|POLY 1.5           |     P=0.122      P=0.478      (e)          P=0.201     |P=0.608N     P=0.469      (e)          (e)          |
|POLY 6             |     P=0.112      P=0.451      (e)          P=0.185     |P=0.646N     P=0.414      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.126      P=0.505      (e)          P=0.233     |P=0.586N     P=0.499      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.126      P=0.500      (e)          P=0.217     |P=0.588N     P=0.495      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Gallbladder                                                                                                                      |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/43 (0%)    1/43 (2%)    1/41 (2%)    0/38 (0%)   |2/46 (4%)    2/45 (4%)    3/48 (6%)    0/43 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.9%         2.8%         0.0%        |4.5%         5.8%         6.8%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    0/22 (0%)    1/28 (4%)    0/24 (0%)   |2/42 (5%)    0/12 (0%)    3/32 (9%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          687          733 (T)      ---         |735 (T)      548          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.584N     P=0.473      P=0.444      (e)         |P=0.245N     P=0.384      P=0.377      P=0.401N     |
|POLY 3             |     P=0.588N     P=0.465      P=0.475      (e)         |P=0.219N     P=0.598      P=0.497      P=0.298N     |
|POLY 1.5           |     P=0.577N     P=0.478      P=0.481      (e)         |P=0.200N     P=0.640      P=0.510      P=0.277N     |
|POLY 6             |     P=0.602N     P=0.451      P=0.467      (e)         |P=0.249N     P=0.534      P=0.475      P=0.328N     |
|LOGISTIC REGRESSION|     P=0.568N     P=0.505      P=0.444      (e)         |P=0.189N     P=0.673N     P=0.377      (e)          |
|COCH-ARM / FISHERS |     P=0.565N     P=0.500      P=0.488      (e)         |P=0.180N     P=0.683      P=0.520      P=0.264N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     39/50 (78%)  41/50 (82%)  42/50 (84%)  41/50 (82%) |45/50 (90%)  39/50 (78%)  46/50 (92%)  38/50 (76%)  |
|POLY-3 ADJUSTED (b)|     80.7%        92.1%        90.5%        90.2%       |94.9%        87.1%        95.6%        86.8%        |
|TERMINAL (d)       |     31/37 (84%)  24/24 (100%) 29/29 (100%) 27/27 (100%)|42/42 (100%) 13/13 (100%) 33/33 (100%) 21/21 (100%) |
|FIRST INCIDENCE    |     559          405          475          370         |664          514          658          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.094      P=0.002 **   P=0.017 *    P=0.010 *   |P=0.065      P<0.001 **   P=0.007 **   P<0.001 **   |
|POLY 3             |     P=0.217      P=0.074      P=0.122      P=0.134     |P=0.171N     P=0.113N     P=0.661      P=0.109N     |
|POLY 1.5           |     P=0.325      P=0.173      P=0.191      P=0.237     |P=0.137N     P=0.084N     P=0.615      P=0.073N     |
|POLY 6             |     P=0.087      P=0.022 *    P=0.059      P=0.050     |P=0.234N     P=0.228N     P=0.710      P=0.216N     |
|LOGISTIC REGRESSION|     P=0.309      P=0.046 *    P=0.083      P=0.088     |P=0.579N     P=0.478      P=0.279      P=0.638      |
|COCH-ARM / FISHERS |     P=0.434      P=0.402      P=0.306      P=0.402     |P=0.096N     P=0.086N     P=0.500      P=0.054N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.7%         2.4%        |0.0%         0.0%         4.3%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          657          645         |---          ---          658          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.320      (e)          P=0.195      P=0.466     |P=0.730      (e)          P=0.224      (e)          |
|POLY 3             |     P=0.333      (e)          P=0.220      P=0.480     |P=0.702      (e)          P=0.235      (e)          |
|POLY 1.5           |     P=0.341      (e)          P=0.227      P=0.488     |P=0.722N     (e)          P=0.237      (e)          |
|POLY 6             |     P=0.320      (e)          P=0.212      P=0.470     |P=0.665      (e)          P=0.229      (e)          |
|LOGISTIC REGRESSION|     P=0.356      (e)          P=0.270      P=0.572     |P=0.690N     (e)          P=0.215      (e)          |
|COCH-ARM / FISHERS |     P=0.350      (e)          P=0.247      P=0.500     |P=0.697N     (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    18/50 (36%)  14/50 (28%)  10/50 (20%) |1/50 (2%)    16/50 (32%)  11/50 (22%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     6.4%         40.6%        30.6%        22.9%       |2.1%         38.3%        23.8%        31.2%        |
|TERMINAL (d)       |     2/37 (5%)    6/24 (25%)   6/29 (21%)   5/27 (19%)  |0/42 (0%)    2/13 (15%)   10/33 (30%)  6/21 (29%)   |
|FIRST INCIDENCE    |     559          405          475          370         |593          426          617          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.387      P<0.001 **   P=0.002 **   P=0.016 *   |P=0.019 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.407      P<0.001 **   P=0.002 **   P=0.024 *   |P=0.025 *    P<0.001 **   P=0.002 **   P<0.001 **   |
|POLY 1.5           |     P=0.448      P<0.001 **   P=0.002 **   P=0.029 *   |P=0.038 *    P<0.001 **   P=0.002 **   P<0.001 **   |
|POLY 6             |     P=0.354      P<0.001 **   P=0.002 **   P=0.020 *   |P=0.013 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.559N     P=0.002 **   P=0.013 *    P=0.081     |P=0.119      P<0.001 **   P=0.003 **   P=0.002 **   |
|COCH-ARM / FISHERS |     P=0.499      P<0.001 **   P=0.003 **   P=0.036 *   |P=0.073      P<0.001 **   P=0.002 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         0.0%         4.8%        |2.1%         2.7%         2.2%         2.6%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          421          ---          706         |593          686          617          594          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.141      P=0.488      (e)          P=0.188     |P=0.627      P=0.670      P=0.758N     P=0.722      |
|POLY 3             |     P=0.137      P=0.472      (e)          P=0.215     |P=0.622      P=0.703      P=0.755      P=0.712      |
|POLY 1.5           |     P=0.142      P=0.482      (e)          P=0.224     |P=0.640      P=0.731      P=0.759      P=0.733      |
|POLY 6             |     P=0.129      P=0.461      (e)          P=0.204     |P=0.596      P=0.658      P=0.748      P=0.684      |
|LOGISTIC REGRESSION|     P=0.157      P=0.985      (e)          P=0.211     |P=0.578N     P=0.715N     P=0.701      P=0.687N     |
|COCH-ARM / FISHERS |     P=0.151      P=0.500      (e)          P=0.247     |P=0.667      P=0.753N     P=0.753N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Epicardium                                                                                                                |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    5/50 (10%)   0/50 (0%)    7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         2.4%         0.0%        |2.1%         12.9%        0.0%         17.5%        |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    1/13 (8%)    0/33 (0%)    2/21 (10%)   |
|FIRST INCIDENCE    |     ---          687          625          ---         |699          533          ---          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.408N     P=0.200      P=0.491      (e)         |P=0.015 *    P=0.028 *    P=0.535N     P=0.007 **   |
|POLY 3             |     P=0.419N     P=0.204      P=0.484      (e)         |P=0.018 *    P=0.064      P=0.505N     P=0.016 *    |
|POLY 1.5           |     P=0.402N     P=0.216      P=0.490      (e)         |P=0.022 *    P=0.080      P=0.501N     P=0.021 *    |
|POLY 6             |     P=0.439N     P=0.194      P=0.475      (e)         |P=0.013 *    P=0.044 *    P=0.512N     P=0.011 *    |
|LOGISTIC REGRESSION|     P=0.373N     P=0.217      P=0.612      (e)         |P=0.065      P=0.164      P=0.503N     P=0.048 *    |
|COCH-ARM / FISHERS |     P=0.378N     P=0.247      P=0.500      (e)         |P=0.032 *    P=0.102      P=0.500N     P=0.030 *    |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Pericardium                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    6/50 (12%)   0/50 (0%)    5/50 (10%)  |0/50 (0%)    9/50 (18%)   0/50 (0%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         14.8%        0.0%         12.0%       |0.0%         22.7%        0.0%         10.5%        |
|TERMINAL (d)       |     0/37 (0%)    2/24 (8%)    0/29 (0%)    3/27 (11%)  |0/42 (0%)    1/13 (8%)    0/33 (0%)    3/21 (14%)   |
|FIRST INCIDENCE    |     ---          562          ---          668         |---          533          ---          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.115      P=0.008 **   (e)          P=0.016 *   |P=0.383      P<0.001 **   (e)          P=0.012 *    |
|POLY 3             |     P=0.108      P=0.009 **   (e)          P=0.023 *   |P=0.388      P<0.001 **   (e)          P=0.038 *    |
|POLY 1.5           |     P=0.120      P=0.011 *    (e)          P=0.026 *   |P=0.446      P<0.001 **   (e)          P=0.047 *    |
|POLY 6             |     P=0.095      P=0.008 **   (e)          P=0.020 *   |P=0.315      P<0.001 **   (e)          P=0.030 *    |
|LOGISTIC REGRESSION|     P=0.143      P=0.018 *    (e)          P=0.022 *   |P=0.564      P=0.005 **   (e)          P=0.022 *    |
|COCH-ARM / FISHERS |     P=0.146      P=0.013 *    (e)          P=0.028 *   |P=0.527      P<0.001 **   (e)          P=0.059      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Ileum: Peyer's Patch                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/45 (11%)   0/47 (0%)    0/43 (0%)    1/45 (2%)   |2/46 (4%)    0/48 (0%)    0/50 (0%)    1/48 (2%)    |
|POLY-3 ADJUSTED (b)|     11.7%        0.0%         0.0%         2.5%        |4.5%         0.0%         0.0%         2.7%         |
|TERMINAL (d)       |     4/37 (11%)   0/24 (0%)    0/29 (0%)    1/27 (4%)   |2/42 (5%)    0/13 (0%)    0/33 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     590          ---          ---          733 (T)     |735 (T)      ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.230N     P=0.081N     P=0.056N     P=0.181N    |P=0.655      P=0.518N     P=0.293N     P=0.733      |
|POLY 3             |     P=0.165N     P=0.040N*    P=0.042N*    P=0.121N    |P=0.614N     P=0.288N     P=0.230N     P=0.557N     |
|POLY 1.5           |     P=0.174N     P=0.034N*    P=0.038N*    P=0.112N    |P=0.628N     P=0.258N     P=0.224N     P=0.525N     |
|POLY 6             |     P=0.157N     P=0.048N*    P=0.046N*    P=0.136N    |P=0.593N     P=0.336N     P=0.242N     P=0.599N     |
|LOGISTIC REGRESSION|     P=0.201N     P=0.031N*    P=0.034N*    P=0.104N    |P=0.655      (e)          (e)          P=0.733      |
|COCH-ARM / FISHERS |     P=0.197N     P=0.025N*    P=0.031N*    P=0.101N    |P=0.645N     P=0.237N     P=0.227N     P=0.484N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   1/50 (2%)    3/49 (6%)    4/47 (9%)   |2/50 (4%)    0/49 (0%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     17.2%        2.5%         7.2%         9.9%        |4.2%         0.0%         4.4%         2.6%         |
|TERMINAL (d)       |     6/37 (16%)   0/24 (0%)    3/29 (10%)   3/27 (11%)  |0/42 (0%)    0/13 (0%)    2/33 (6%)    1/21 (5%)    |
|FIRST INCIDENCE    |     590          687          733 (T)      715         |664          ---          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.517N     P=0.065N     P=0.190N     P=0.351N    |P=0.608      P=0.400N     P=0.631      P=0.685N     |
|POLY 3             |     P=0.426N     P=0.030N*    P=0.137N     P=0.253N    |P=0.610N     P=0.298N     P=0.683      P=0.575N     |
|POLY 1.5           |     P=0.434N     P=0.024N*    P=0.123N     P=0.233N    |P=0.604N     P=0.270N     P=0.690      P=0.544N     |
|POLY 6             |     P=0.428N     P=0.038N*    P=0.157N     P=0.281N    |P=0.617N     P=0.344N     P=0.668      P=0.614N     |
|LOGISTIC REGRESSION|     P=0.485N     P=0.031N*    P=0.148N     P=0.268N    |P=0.653N     P=0.223N     P=0.695      P=0.539N     |
|COCH-ARM / FISHERS |     P=0.461N     P=0.015N*    P=0.106N     P=0.210N    |P=0.593N     P=0.253N     P=0.691N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Amyloid Deposition                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         4.7%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          562          ---          533         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.275      P=0.180      (e)          P=0.217     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.261      P=0.205      (e)          P=0.219     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.272      P=0.217      (e)          P=0.226     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.249      P=0.195      (e)          P=0.210     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.300      P=0.279      (e)          P=0.414     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.288      P=0.247      (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.3%         2.5%         0.0%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     2/37 (5%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      700          ---          ---         |---          ---          547          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.196N     P=0.625N     P=0.293N     P=0.310N    |P=0.805N     (e)          P=0.508      (e)          |
|POLY 3             |     P=0.166N     P=0.555N     P=0.260N     P=0.262N    |P=0.781      (e)          P=0.498      (e)          |
|POLY 1.5           |     P=0.167N     P=0.535N     P=0.253N     P=0.252N    |P=0.795N     (e)          P=0.500      (e)          |
|POLY 6             |     P=0.167N     P=0.575N     P=0.271N     P=0.275N    |P=0.754      (e)          P=0.493      (e)          |
|LOGISTIC REGRESSION|     P=0.185N     P=0.585N     (e)          (e)         |P=0.690N     (e)          P=0.361      (e)          |
|COCH-ARM / FISHERS |     P=0.170N     P=0.500N     P=0.253N     P=0.247N    |P=0.785N     (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.8%        |2.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    1/27 (4%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          671         |593          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.034 *    (e)          (e)          P=0.184     |P=0.489N     P=0.547N     P=0.500N     P=0.536N     |
|POLY 3             |     P=0.040 *    (e)          (e)          P=0.215     |P=0.437N     P=0.550N     P=0.506N     P=0.543N     |
|POLY 1.5           |     P=0.040 *    (e)          (e)          P=0.224     |P=0.454N     P=0.529N     P=0.502N     P=0.525N     |
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.205     |P=0.413N     P=0.583N     P=0.514N     P=0.566N     |
|LOGISTIC REGRESSION|     P=0.040 *    (e)          (e)          P=0.222     |P=0.406N     P=0.459N     P=0.588N     P=0.426N     |
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |P=0.473N     P=0.505N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   0/50 (0%)    2/49 (4%)    1/50 (2%)   |2/50 (4%)    3/49 (6%)    4/50 (8%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     10.8%        0.0%         4.8%         2.4%        |4.3%         8.1%         8.7%         5.2%         |
|TERMINAL (d)       |     4/37 (11%)   0/24 (0%)    2/29 (7%)    1/27 (4%)   |1/42 (2%)    1/13 (8%)    3/33 (9%)    1/21 (5%)    |
|FIRST INCIDENCE    |     726          ---          733 (T)      733 (T)     |715          645          685          633          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.265N     P=0.084N     P=0.325N     P=0.190N    |P=0.549      P=0.178      P=0.250      P=0.482      |
|POLY 3             |     P=0.192N     P=0.047N*    P=0.259N     P=0.128N    |P=0.589N     P=0.396      P=0.328      P=0.619      |
|POLY 1.5           |     P=0.196N     P=0.040N*    P=0.245N     P=0.117N    |P=0.555N     P=0.441      P=0.336      P=0.651      |
|POLY 6             |     P=0.192N     P=0.055N     P=0.279N     P=0.144N    |P=0.558      P=0.331      P=0.314      P=0.577      |
|LOGISTIC REGRESSION|     P=0.261N     P=0.068N     P=0.320N     P=0.174N    |P=0.567N     P=0.418      P=0.321      P=0.647      |
|COCH-ARM / FISHERS |     P=0.211N     P=0.028N*    P=0.226N     P=0.102N    |P=0.503N     P=0.490      P=0.339      P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     47/50 (94%)  40/50 (80%)  41/49 (84%)  41/50 (82%) |37/50 (74%)  30/49 (61%)  43/50 (86%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     95.9%        86.8%        88.8%        90.4%       |76.9%        70.8%        89.5%        82.8%        |
|TERMINAL (d)       |     36/37 (97%)  22/24 (92%)  28/29 (97%)  27/27 (100%)|34/42 (81%)  9/13 (69%)   31/33 (94%)  18/21 (86%)  |
|FIRST INCIDENCE    |     561          405          475          562         |264          514          617          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.334      P=0.092      P=0.300      P=0.152     |P=0.009 **   P<0.001 **   P=0.003 **   P<0.001 **   |
|POLY 3             |     P=0.434N     P=0.088N     P=0.148N     P=0.217N    |P=0.162      P=0.329N     P=0.071      P=0.320      |
|POLY 1.5           |     P=0.309N     P=0.062N     P=0.117N     P=0.122N    |P=0.237      P=0.221N     P=0.085      P=0.452      |
|POLY 6             |     P=0.573      P=0.119N     P=0.221N     P=0.463N    |P=0.106      P=0.517N     P=0.055      P=0.198      |
|LOGISTIC REGRESSION|     P=0.261N     P=0.213N     P=0.270N     P=0.424N    |P=0.095      P=0.427N     P=0.093      P=0.263      |
|COCH-ARM / FISHERS |     P=0.212N     P=0.036N*    P=0.094N     P=0.061N    |P=0.420      P=0.126N     P=0.105      P=0.500N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Artery                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   6/49 (12%)   2/50 (4%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         12.5%        14.2%        4.8%        |0.0%         0.0%         2.2%         7.6%         |
|TERMINAL (d)       |     0/37 (0%)    3/24 (13%)   4/29 (14%)   1/27 (4%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          504          491          685         |---          ---          617          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.563      P=0.012 *    P=0.010 *    P=0.183     |P=0.013 *    (e)          P=0.504      P=0.085      |
|POLY 3             |     P=0.573      P=0.020 *    P=0.011 *    P=0.215     |P=0.017 *    (e)          P=0.497      P=0.091      |
|POLY 1.5           |     P=0.592N     P=0.023 *    P=0.012 *    P=0.224     |P=0.019 *    (e)          P=0.500      P=0.102      |
|POLY 6             |     P=0.533      P=0.017 *    P=0.010 *    P=0.204     |P=0.016 *    (e)          P=0.492      P=0.079      |
|LOGISTIC REGRESSION|     P=0.559N     P=0.027 *    P=0.017 *    P=0.213     |P=0.055      (e)          P=0.436      P=0.191      |
|COCH-ARM / FISHERS |     P=0.551N     P=0.028 *    P=0.012 *    P=0.247     |P=0.022 *    (e)          P=0.500      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Capsule                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          491          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.703N     (e)          P=0.223      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.712N     (e)          P=0.220      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.705N     (e)          P=0.225      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.722      (e)          P=0.214      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.691N     (e)          P=0.467      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.697N     (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/49 (6%)    5/50 (10%)  |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.7%        5.1%         7.2%         12.1%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/37 (8%)    2/24 (8%)    3/29 (10%)   5/27 (19%)  |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     590          733 (T)      733 (T)      733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.278      P=0.391N     P=0.489N     P=0.441     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.354      P=0.294N     P=0.422N     P=0.552     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.364      P=0.264N     P=0.399N     P=0.584     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.334      P=0.329N     P=0.452N     P=0.508     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.312      P=0.270N     P=0.400N     P=0.548     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.368      P=0.218N     P=0.369N     P=0.630N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   3/49 (6%)    1/49 (2%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     10.5%        7.7%         2.4%         9.7%        |0.0%         2.7%         2.2%         5.2%         |
|TERMINAL (d)       |     1/37 (3%)    1/24 (4%)    0/29 (0%)    4/27 (15%)  |0/42 (0%)    1/13 (8%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     559          574          650          733 (T)     |---          735 (T)      729          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.534      P=0.522N     P=0.151N     P=0.614     |P=0.132      P=0.267      P=0.458      P=0.139      |
|POLY 3             |     P=0.586      P=0.465N     P=0.132N     P=0.585N    |P=0.155      P=0.453      P=0.496      P=0.195      |
|POLY 1.5           |     P=0.592N     P=0.429N     P=0.121N     P=0.550N    |P=0.170      P=0.475      P=0.499      P=0.212      |
|POLY 6             |     P=0.563      P=0.501N     P=0.148N     P=0.629N    |P=0.135      P=0.420      P=0.489      P=0.176      |
|LOGISTIC REGRESSION|     P=0.581N     P=0.254N     P=0.043N*    P=0.475N    |P=0.148      P=0.267      P=0.482      P=0.199      |
|COCH-ARM / FISHERS |     P=0.584N     P=0.369N     P=0.107N     P=0.500N    |P=0.194      P=0.500      P=0.500      P=0.247      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Squamous Epithelium                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   3/49 (6%)    4/49 (8%)    7/50 (14%)  |9/50 (18%)   17/50 (34%)  10/50 (20%)  15/50 (30%)  |
|POLY-3 ADJUSTED (b)|     12.8%        7.4%         9.2%         15.7%       |19.2%        40.8%        21.3%        35.3%        |
|TERMINAL (d)       |     4/37 (11%)   0/24 (0%)    0/29 (0%)    1/27 (4%)   |9/42 (21%)   4/13 (31%)   6/33 (18%)   2/21 (10%)   |
|FIRST INCIDENCE    |     590          405          478          370         |735 (T)      426          617          487          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.215      P=0.404N     P=0.479N     P=0.360     |P=0.091      P<0.001 **   P=0.321      P=0.009 **   |
|POLY 3             |     P=0.260      P=0.320N     P=0.420N     P=0.460     |P=0.194      P=0.020 *    P=0.501      P=0.068      |
|POLY 1.5           |     P=0.261      P=0.295N     P=0.405N     P=0.478     |P=0.220      P=0.033 *    P=0.507      P=0.085      |
|POLY 6             |     P=0.252      P=0.345N     P=0.439N     P=0.434     |P=0.169      P=0.009 **   P=0.486      P=0.053      |
|LOGISTIC REGRESSION|     P=0.287      P=0.092N     P=0.236N     P=0.416N    |P=0.332      P=0.063      P=0.489      P=0.127      |
|COCH-ARM / FISHERS |     P=0.253      P=0.254N     P=0.383N     P=0.500     |P=0.277      P=0.055      P=0.500      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Amyloid Deposition                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          562          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.385N     P=0.180      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.406N     P=0.205      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.392N     P=0.217      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.422N     P=0.195      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.361N     P=0.279      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.369N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.2%         5.3%         |
|TERMINAL (d)       |     1/37 (3%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    1/33 (3%)    2/21 (10%)   |
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |---          ---          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.499N     P=0.586N     P=0.549N     P=0.563N    |P=0.042 *    (e)          P=0.452      P=0.104      |
|POLY 3             |     P=0.450N     P=0.532N     P=0.518N     P=0.522N    |P=0.068      (e)          P=0.496      P=0.194      |
|POLY 1.5           |     P=0.459N     P=0.520N     P=0.511N     P=0.513N    |P=0.074      (e)          P=0.499      P=0.211      |
|POLY 6             |     P=0.442N     P=0.544N     P=0.528N     P=0.533N    |P=0.061      (e)          P=0.489      P=0.174      |
|LOGISTIC REGRESSION|     P=0.499N     (e)          (e)          (e)         |(e)          (e)          P=0.452      P=0.104      |
|COCH-ARM / FISHERS |     P=0.474N     P=0.500N     P=0.500N     P=0.500N    |P=0.084      (e)          P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.3%         2.6%         4.7%         0.0%        |4.3%         5.4%         0.0%         5.1%         |
|TERMINAL (d)       |     0/37 (0%)    1/24 (4%)    1/29 (3%)    0/27 (0%)   |2/42 (5%)    1/13 (8%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     559          733 (T)      475          ---         |735 (T)      645          ---          496          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.238N     P=0.612N     P=0.641      P=0.283N    |P=0.529      P=0.341      P=0.293N     P=0.543      |
|POLY 3             |     P=0.220N     P=0.561N     P=0.663      P=0.265N    |P=0.586      P=0.608      P=0.242N     P=0.627      |
|POLY 1.5           |     P=0.215N     P=0.538N     P=0.676      P=0.254N    |P=0.599      P=0.650      P=0.239N     P=0.655      |
|POLY 6             |     P=0.229N     P=0.584N     P=0.645      P=0.280N    |P=0.568      P=0.543      P=0.250N     P=0.590      |
|LOGISTIC REGRESSION|     P=0.200N     P=0.469N     P=0.498N     P=0.146N    |P=0.610N     P=0.570      (e)          P=0.625N     |
|COCH-ARM / FISHERS |     P=0.211N     P=0.500N     P=0.691N     P=0.247N    |P=0.618      P=0.691N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.3%         2.6%         4.7%         0.0%        |4.3%         0.0%         0.0%         5.2%         |
|TERMINAL (d)       |     2/37 (5%)    1/24 (4%)    2/29 (7%)    0/27 (0%)   |2/42 (5%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      ---         |735 (T)      ---          ---          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.251N     P=0.650N     P=0.605      P=0.310N    |P=0.293      P=0.518N     P=0.293N     P=0.466      |
|POLY 3             |     P=0.218N     P=0.557N     P=0.661      P=0.262N    |P=0.386      P=0.294N     P=0.242N     P=0.618      |
|POLY 1.5           |     P=0.214N     P=0.536N     P=0.675      P=0.252N    |P=0.382      P=0.266N     P=0.239N     P=0.650      |
|POLY 6             |     P=0.226N     P=0.577N     P=0.643      P=0.275N    |P=0.393      P=0.339N     P=0.250N     P=0.575      |
|LOGISTIC REGRESSION|     P=0.251N     P=0.650N     P=0.605      (e)         |P=0.313      (e)          (e)          P=0.569      |
|COCH-ARM / FISHERS |     P=0.211N     P=0.500N     P=0.691N     P=0.247N    |P=0.381      P=0.247N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  16/50 (32%)  19/50 (38%)  18/50 (36%) |6/50 (12%)   9/50 (18%)   4/50 (8%)    12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     21.3%        40.1%        43.9%        42.2%       |12.7%        23.3%        8.7%         30.5%        |
|TERMINAL (d)       |     8/37 (22%)   13/24 (54%)  16/29 (55%)  14/27 (52%) |4/42 (10%)   2/13 (15%)   4/33 (12%)   9/21 (43%)   |
|FIRST INCIDENCE    |     590          574          491          589         |678          630          735 (T)      533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.038 *    P=0.009 **   P=0.007 **   P=0.008 **  |P=0.016 *    P=0.014 *    P=0.511N     P=0.003 **   |
|POLY 3             |     P=0.067      P=0.044 *    P=0.016 *    P=0.025 *   |P=0.041 *    P=0.159      P=0.388N     P=0.037 *    |
|POLY 1.5           |     P=0.088      P=0.068      P=0.023 *    P=0.036 *   |P=0.054      P=0.214      P=0.376N     P=0.056      |
|POLY 6             |     P=0.045 *    P=0.028 *    P=0.009 **   P=0.016 *   |P=0.028 *    P=0.098      P=0.414N     P=0.021 *    |
|LOGISTIC REGRESSION|     P=0.069      P=0.038 *    P=0.018 *    P=0.026 *   |P=0.043 *    P=0.169      P=0.401N     P=0.035 *    |
|COCH-ARM / FISHERS |     P=0.119      P=0.127      P=0.038 *    P=0.059     |P=0.081      P=0.288      P=0.370N     P=0.096      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    3/50 (6%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |6.3%         7.7%         8.6%         7.7%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |1/42 (2%)    0/13 (0%)    2/33 (6%)    1/21 (5%)    |
|FIRST INCIDENCE    |     669          ---          ---          ---         |664          426          672          578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.499N     P=0.541N     P=0.535N     P=0.547N    |P=0.477      P=0.473      P=0.433      P=0.453      |
|POLY 3             |     P=0.449N     P=0.533N     P=0.519N     P=0.523N    |P=0.521      P=0.568      P=0.488      P=0.569      |
|POLY 1.5           |     P=0.458N     P=0.521N     P=0.511N     P=0.513N    |P=0.554      P=0.614      P=0.497      P=0.608      |
|POLY 6             |     P=0.441N     P=0.546N     P=0.530N     P=0.534N    |P=0.478      P=0.493      P=0.469      P=0.518      |
|LOGISTIC REGRESSION|     P=0.471N     P=0.477N     P=0.460N     P=0.464N    |P=0.479N     P=0.493N     P=0.494      P=0.626N     |
|COCH-ARM / FISHERS |     P=0.474N     P=0.500N     P=0.500N     P=0.500N    |P=0.590N     P=0.661N     P=0.500      P=0.661N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    2/50 (4%)    7/50 (14%)  |4/50 (8%)    3/50 (6%)    9/50 (18%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     8.5%         9.6%         4.7%         16.4%       |8.5%         8.0%         19.5%        7.8%         |
|TERMINAL (d)       |     1/37 (3%)    0/24 (0%)    0/29 (0%)    1/27 (4%)   |2/42 (5%)    0/13 (0%)    6/33 (18%)   0/21 (0%)    |
|FIRST INCIDENCE    |     607          504          678          501         |678          657          685          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.118      P=0.513      P=0.432N     P=0.163     |P=0.509      P=0.383      P=0.063      P=0.534      |
|POLY 3             |     P=0.125      P=0.573      P=0.385N     P=0.207     |P=0.558N     P=0.621N     P=0.107      P=0.606N     |
|POLY 1.5           |     P=0.133      P=0.598      P=0.365N     P=0.229     |P=0.518N     P=0.565N     P=0.114      P=0.563N     |
|POLY 6             |     P=0.113      P=0.547      P=0.411N     P=0.182     |P=0.544      P=0.600      P=0.095      P=0.645      |
|LOGISTIC REGRESSION|     P=0.157      P=0.308N     P=0.253N     P=0.337     |P=0.546N     P=0.593N     P=0.108      P=0.555N     |
|COCH-ARM / FISHERS |     P=0.143      P=0.643N     P=0.339N     P=0.262     |P=0.457N     P=0.500N     P=0.117      P=0.500N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Tension Lipidosis                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.3%         2.6%         0.0%         0.0%        |4.3%         2.7%         4.4%         2.6%         |
|TERMINAL (d)       |     2/37 (5%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |2/42 (5%)    0/13 (0%)    2/33 (6%)    1/21 (5%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          ---         |735 (T)      580          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.195N     P=0.650N     P=0.293N     P=0.310N    |P=0.603N     P=0.712      P=0.605      P=0.733      |
|POLY 3             |     P=0.165N     P=0.557N     P=0.258N     P=0.262N    |P=0.516N     P=0.577N     P=0.686      P=0.572N     |
|POLY 1.5           |     P=0.166N     P=0.536N     P=0.249N     P=0.252N    |P=0.502N     P=0.541N     P=0.692      P=0.542N     |
|POLY 6             |     P=0.166N     P=0.577N     P=0.269N     P=0.275N    |P=0.535N     P=0.630N     P=0.674      P=0.610N     |
|LOGISTIC REGRESSION|     P=0.195N     P=0.650N     (e)          (e)         |P=0.532N     P=0.498N     P=0.605      P=0.733      |
|COCH-ARM / FISHERS |     P=0.169N     P=0.500N     P=0.247N     P=0.247N    |P=0.479N     P=0.500N     P=0.691N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.3%         0.0%         2.4%         0.0%        |2.1%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     2/37 (5%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          625          ---         |715          ---          699          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.299N     P=0.338N     P=0.561N     P=0.310N    |P=0.523N     P=0.697N     P=0.718      P=0.616N     |
|POLY 3             |     P=0.258N     P=0.275N     P=0.528N     P=0.262N    |P=0.466N     P=0.547N     P=0.756      P=0.542N     |
|POLY 1.5           |     P=0.261N     P=0.261N     P=0.517N     P=0.252N    |P=0.466N     P=0.525N     P=0.759      P=0.524N     |
|POLY 6             |     P=0.257N     P=0.291N     P=0.543N     P=0.275N    |P=0.466N     P=0.580N     P=0.749      P=0.564N     |
|LOGISTIC REGRESSION|     P=0.276N     (e)          P=0.498N     (e)         |P=0.490N     P=0.587N     P=0.762      P=0.552N     |
|COCH-ARM / FISHERS |     P=0.271N     P=0.247N     P=0.500N     P=0.247N    |P=0.464N     P=0.500N     P=0.753N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    49/50 (98%)  42/50 (84%)  49/50 (98%) |0/50 (0%)    49/50 (98%)  35/50 (70%)  49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     0.0%         99.7%        85.0%        98.0%       |0.0%         98.0%        71.4%        98.0%        |
|TERMINAL (d)       |     0/37 (0%)    24/24 (100%) 23/29 (79%)  26/27 (96%) |0/42 (0%)    12/13 (92%)  22/33 (67%)  20/21 (95%)  |
|FIRST INCIDENCE    |     ---          331          475          370         |---          426          547          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    2/50 (4%)    2/50 (4%)   |4/50 (8%)    3/50 (6%)    4/50 (8%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     10.7%        2.5%         4.7%         4.8%        |8.5%         7.9%         8.6%         9.8%         |
|TERMINAL (d)       |     3/37 (8%)    0/24 (0%)    2/29 (7%)    1/27 (4%)   |4/42 (10%)   1/13 (8%)    2/33 (6%)    0/21 (0%)    |
|FIRST INCIDENCE    |     664          700          733 (T)      668         |735 (T)      589          617          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.416N     P=0.197N     P=0.318N     P=0.340N    |P=0.379      P=0.361      P=0.541      P=0.420      |
|POLY 3             |     P=0.334N     P=0.146N     P=0.259N     P=0.264N    |P=0.481      P=0.613N     P=0.639      P=0.563      |
|POLY 1.5           |     P=0.335N     P=0.128N     P=0.241N     P=0.244N    |P=0.499      P=0.560N     P=0.642N     P=0.599      |
|POLY 6             |     P=0.339N     P=0.167N     P=0.285N     P=0.291N    |P=0.455      P=0.611      P=0.626      P=0.514      |
|LOGISTIC REGRESSION|     P=0.370N     P=0.131N     P=0.258N     P=0.240N    |P=0.508N     P=0.552N     P=0.644      P=0.435N     |
|COCH-ARM / FISHERS |     P=0.344N     P=0.102N     P=0.218N     P=0.218N    |P=0.521      P=0.500N     P=0.643N     P=0.643N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    50/50 (100%) 45/50 (90%)  46/50 (92%) |2/50 (4%)    49/50 (98%)  45/50 (90%)  50/50 (100%) |
|POLY-3 ADJUSTED (b)|     4.3%         100.0%       93.6%        95.5%       |4.3%         98.4%        92.9%        100.0%       |
|TERMINAL (d)       |     2/37 (5%)    24/24 (100%) 28/29 (97%)  26/27 (96%) |2/42 (5%)    13/13 (100%) 33/33 (100%) 21/21 (100%) |
|FIRST INCIDENCE    |     733 (T)      331          475          370         |735 (T)      426          617          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   3/50 (6%)    7/50 (14%)  |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.3%         12.8%        7.1%         16.9%       |0.0%         2.7%         2.2%         5.3%         |
|TERMINAL (d)       |     2/37 (5%)    5/24 (21%)   3/29 (10%)   7/27 (26%)  |0/42 (0%)    0/13 (0%)    1/33 (3%)    2/21 (10%)   |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |---          514          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.046 *    P=0.077      P=0.389      P=0.025 *   |P=0.124      P=0.496      P=0.452      P=0.104      |
|POLY 3             |     P=0.067      P=0.155      P=0.459      P=0.055     |P=0.153      P=0.457      P=0.496      P=0.194      |
|POLY 1.5           |     P=0.076      P=0.177      P=0.476      P=0.064     |P=0.169      P=0.477      P=0.499      P=0.211      |
|POLY 6             |     P=0.056      P=0.135      P=0.437      P=0.045 *   |P=0.132      P=0.425      P=0.489      P=0.174      |
|LOGISTIC REGRESSION|     P=0.046 *    P=0.077      P=0.389      P=0.025 *   |P=0.195      P=0.520      P=0.452      P=0.104      |
|COCH-ARM / FISHERS |     P=0.089      P=0.218      P=0.500      P=0.080     |P=0.194      P=0.500      P=0.500      P=0.247      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         0.0%         0.0%        |0.0%         5.4%         4.3%         7.9%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    1/13 (8%)    1/33 (3%)    3/21 (14%)   |
|FIRST INCIDENCE    |     ---          706          ---          ---         |---          686          691          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.592N     P=0.434      (e)          (e)         |P=0.081      P=0.080      P=0.198      P=0.031 *    |
|POLY 3             |     P=0.602N     P=0.468      (e)          (e)         |P=0.108      P=0.190      P=0.233      P=0.086      |
|POLY 1.5           |     P=0.592N     P=0.480      (e)          (e)         |P=0.127      P=0.211      P=0.237      P=0.098      |
|POLY 6             |     P=0.611N     P=0.457      (e)          (e)         |P=0.086      P=0.161      P=0.226      P=0.072      |
|LOGISTIC REGRESSION|     P=0.584N     P=0.472      (e)          (e)         |P=0.099      P=0.149      P=0.237      P=0.031 *    |
|COCH-ARM / FISHERS |     P=0.576N     P=0.500      (e)          (e)         |P=0.156      P=0.247      P=0.247      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Proteinosis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    14/50 (28%)  0/50 (0%)    10/50 (20%) |0/50 (0%)    31/50 (62%)  0/50 (0%)    8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     0.0%         35.1%        0.0%         22.7%       |0.0%         74.0%        0.0%         19.4%        |
|TERMINAL (d)       |     0/37 (0%)    12/24 (50%)  0/29 (0%)    5/27 (19%)  |0/42 (0%)    13/13 (100%) 0/33 (0%)    3/21 (14%)   |
|FIRST INCIDENCE    |     ---          504          ---          370         |---          514          ---          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.052      P<0.001 **   (e)          P<0.001 **  |P=0.321N     P<0.001 **   (e)          P<0.001 **   |
|POLY 3             |     P=0.047 *    P<0.001 **   (e)          P<0.001 **  |P=0.154N     P<0.001 **   (e)          P=0.002 **   |
|POLY 1.5           |     P=0.056      P<0.001 **   (e)          P<0.001 **  |P=0.105N     P<0.001 **   (e)          P=0.003 **   |
|POLY 6             |     P=0.038 *    P<0.001 **   (e)          P<0.001 **  |P=0.250N     P<0.001 **   (e)          P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.084      P<0.001 **   (e)          P=0.004 **  |P=0.072N     P<0.001 **   (e)          P=0.017 *    |
|COCH-ARM / FISHERS |     P=0.084      P<0.001 **   (e)          P<0.001 **  |P=0.122N     P<0.001 **   (e)          P=0.003 **   |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Artery, Mediastinum                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         4.7%         0.0%        |0.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    2/24 (8%)    1/29 (3%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    1/33 (3%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      491          ---         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.417N     P=0.149      P=0.207      (e)         |P=0.798      (e)          P=0.452      (e)          |
|POLY 3             |     P=0.424N     P=0.203      P=0.221      (e)         |P=0.782      (e)          P=0.496      (e)          |
|POLY 1.5           |     P=0.406N     P=0.215      P=0.228      (e)         |P=0.796N     (e)          P=0.499      (e)          |
|POLY 6             |     P=0.448N     P=0.191      P=0.212      (e)         |P=0.756      (e)          P=0.489      (e)          |
|LOGISTIC REGRESSION|     P=0.377N     P=0.149      P=0.369      (e)         |(e)          (e)          P=0.452      (e)          |
|COCH-ARM / FISHERS |     P=0.381N     P=0.247      P=0.247      (e)         |P=0.786N     (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Bronchiole, Bronchus                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.3%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          727          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.022 *    (e)          (e)          P=0.113      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.036 *    (e)          (e)          P=0.194      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.037 *    (e)          (e)          P=0.211      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.034 *    (e)          (e)          P=0.174      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.024 *    (e)          (e)          P=0.134      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.1%         0.0%         0.0%        |0.0%         2.7%         0.0%         5.1%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          687          ---          ---         |---          727          ---          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.400N     P=0.209      (e)          (e)         |P=0.126      P=0.295      (e)          P=0.222      |
|POLY 3             |     P=0.407N     P=0.204      (e)          (e)         |P=0.127      P=0.453      (e)          P=0.201      |
|POLY 1.5           |     P=0.392N     P=0.216      (e)          (e)         |P=0.137      P=0.475      (e)          P=0.215      |
|POLY 6             |     P=0.423N     P=0.194      (e)          (e)         |P=0.114      P=0.421      (e)          P=0.182      |
|LOGISTIC REGRESSION|     P=0.370N     P=0.225      (e)          (e)         |P=0.255      P=0.352      (e)          P=0.367      |
|COCH-ARM / FISHERS |     P=0.369N     P=0.247      (e)          (e)         |P=0.151      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Serosa                                                                                                                     |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    50/50 (100%) 49/50 (98%)  50/50 (100%)|0/50 (0%)    50/50 (100%) 47/50 (94%)  49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       99.4%        100.0%      |0.0%         100.0%       96.5%        98.0%        |
|TERMINAL (d)       |     0/37 (0%)    24/24 (100%) 29/29 (100%) 27/27 (100%)|0/42 (0%)    13/13 (100%) 33/33 (100%) 20/21 (95%)  |
|FIRST INCIDENCE    |     ---          331          475          370         |---          426          617          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/35 (0%)    43/48 (90%)  40/45 (89%)  40/48 (83%) |0/36 (0%)    44/50 (88%)  33/48 (69%)  40/50 (80%)  |
|POLY-3 ADJUSTED (b)|     0.0%         90.6%        90.8%        85.5%       |0.0%         89.6%        71.2%        81.5%        |
|TERMINAL (d)       |     0/30 (0%)    21/24 (88%)  22/24 (92%)  22/27 (82%) |0/29 (0%)    11/13 (85%)  22/32 (69%)  16/21 (76%)  |
|FIRST INCIDENCE    |     ---          331          475          370         |---          426          617          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/35 (6%)    36/48 (75%)  22/45 (49%)  22/48 (46%) |5/36 (14%)   42/50 (84%)  31/48 (65%)  28/50 (56%)  |
|POLY-3 ADJUSTED (b)|     5.9%         76.6%        54.8%        52.7%       |14.8%        88.2%        67.4%        60.5%        |
|TERMINAL (d)       |     1/30 (3%)    17/24 (71%)  14/24 (58%)  17/27 (63%) |5/29 (17%)   12/13 (92%)  22/32 (69%)  12/21 (57%)  |
|FIRST INCIDENCE    |     664          331          475          562         |735 (T)      426          617          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.117      P<0.001 **   P<0.001 **   P<0.001 **  |P=0.029 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.123      P<0.001 **   P<0.001 **   P<0.001 **  |P=0.221      P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.196      P<0.001 **   P<0.001 **   P<0.001 **  |P=0.250      P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.061      P<0.001 **   P<0.001 **   P<0.001 **  |P=0.186      P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.368      P<0.001 **   P<0.001 **   P<0.001 **  |P=0.429      P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.349      P<0.001 **   P<0.001 **   P<0.001 **  |P=0.311      P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial: Artery                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/35 (0%)    0/48 (0%)    0/45 (0%)    1/48 (2%)   |0/36 (0%)    2/50 (4%)    1/48 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.5%        |0.0%         5.3%         2.3%         2.6%         |
|TERMINAL (d)       |     0/30 (0%)    0/24 (0%)    0/24 (0%)    1/27 (4%)   |0/29 (0%)    1/13 (8%)    0/32 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          589          687          705          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.217      (e)          (e)          P=0.479     |P=0.575      P=0.139      P=0.481      P=0.400      |
|POLY 3             |     P=0.230      (e)          (e)          P=0.535     |P=0.597      P=0.258      P=0.554      P=0.524      |
|POLY 1.5           |     P=0.234      (e)          (e)          P=0.547     |P=0.627      P=0.282      P=0.556      P=0.541      |
|POLY 6             |     P=0.223      (e)          (e)          P=0.519     |P=0.557      P=0.225      P=0.550      P=0.504      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.479     |P=0.659N     P=0.347      P=0.561      P=0.529      |
|COCH-ARM / FISHERS |     P=0.237      (e)          (e)          P=0.578     |P=0.661N     P=0.335      P=0.571      P=0.581      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/28 (4%)    2/32 (6%)    1/33 (3%)    0/36 (0%)   |0/36 (0%)    0/36 (0%)    0/43 (0%)    1/42 (2%)    |
|POLY-3 ADJUSTED (b)|     3.8%         7.8%         3.7%         0.0%        |0.0%         0.0%         0.0%         3.1%         |
|TERMINAL (d)       |     1/21 (5%)    2/18 (11%)   1/18 (6%)    0/22 (0%)   |0/30 (0%)    0/9 (0%)     0/28 (0%)    1/17 (6%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      ---         |---          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.209N     P=0.445      P=0.728      P=0.491N    |P=0.176      (e)          (e)          P=0.387      |
|POLY 3             |     P=0.212N     P=0.492      P=0.754N     P=0.476N    |P=0.217      (e)          (e)          P=0.492      |
|POLY 1.5           |     P=0.203N     P=0.511      P=0.741N     P=0.466N    |P=0.223      (e)          (e)          P=0.508      |
|POLY 6             |     P=0.223N     P=0.478      P=0.752      P=0.487N    |P=0.209      (e)          (e)          P=0.471      |
|LOGISTIC REGRESSION|     P=0.209N     P=0.445      P=0.728      (e)         |(e)          (e)          (e)          P=0.387      |
|COCH-ARM / FISHERS |     P=0.189N     P=0.551      P=0.711N     P=0.437N    |P=0.234      (e)          (e)          P=0.538      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/40 (0%)    24/49 (49%)  14/45 (31%)  25/48 (52%) |0/42 (0%)    20/48 (42%)  7/46 (15%)   16/49 (33%)  |
|POLY-3 ADJUSTED (b)|     0.0%         54.2%        34.3%        56.9%       |0.0%         48.2%        16.5%        36.8%        |
|TERMINAL (d)       |     0/31 (0%)    7/23 (30%)   8/27 (30%)   16/27 (59%) |0/37 (0%)    3/12 (25%)   4/29 (14%)   7/21 (33%)   |
|FIRST INCIDENCE    |     ---          405          491          370         |---          426          658          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.008 **   P<0.001 **   P=0.006 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.014 *    P<0.001 **   P=0.009 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.020 *    P<0.001 **   P=0.009 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.007 **   P<0.001 **   P=0.007 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.175      P<0.001 **   P=0.012 *    P=0.002 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.041 *    P<0.001 **   P=0.008 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/40 (0%)    34/49 (69%)  17/45 (38%)  27/48 (56%) |2/42 (5%)    40/48 (83%)  11/46 (24%)  29/49 (59%)  |
|POLY-3 ADJUSTED (b)|     0.0%         75.6%        41.9%        61.4%       |5.0%         87.4%        25.7%        62.7%        |
|TERMINAL (d)       |     0/31 (0%)    17/23 (74%)  11/27 (41%)  17/27 (63%) |2/37 (5%)    10/12 (83%)  6/29 (21%)   12/21 (57%)  |
|FIRST INCIDENCE    |     ---          331          562          370         |735 (T)      426          664          197          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.003 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.002 **   P<0.001 **   P=0.004 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.002 **   P<0.001 **   P=0.009 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.002 **   P<0.001 **   P=0.010 *    P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P=0.007 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.006 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.068      P<0.001 **   P=0.012 *    P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.006 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.016 *    P<0.001 **   P=0.011 *    P<0.001 **   |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal: Artery                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/40 (0%)    1/49 (2%)    2/45 (4%)    1/48 (2%)   |0/42 (0%)    0/48 (0%)    0/46 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         5.2%         2.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/31 (0%)    1/23 (4%)    2/27 (7%)    1/27 (4%)   |0/37 (0%)    0/12 (0%)    0/29 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.492      P=0.440      P=0.208      P=0.472     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.502      P=0.507      P=0.246      P=0.516     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.515      P=0.520      P=0.254      P=0.524     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.482      P=0.493      P=0.236      P=0.505     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.440      P=0.208      P=0.472     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.530      P=0.551      P=0.277      P=0.545     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/48 (23%)  2/47 (4%)    10/49 (20%)  10/45 (22%) |8/48 (17%)   6/49 (12%)   7/50 (14%)   7/48 (15%)   |
|POLY-3 ADJUSTED (b)|     24.7%        5.5%         23.4%        26.1%       |17.6%        15.8%        15.1%        18.7%        |
|TERMINAL (d)       |     9/36 (25%)   2/21 (10%)   6/29 (21%)   9/26 (35%)  |7/41 (17%)   0/13 (0%)    4/33 (12%)   4/21 (19%)   |
|FIRST INCIDENCE    |     669          733 (T)      625          645         |678          617          672          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.152      P=0.067N     P=0.488      P=0.374     |P=0.347      P=0.210      P=0.568      P=0.268      |
|POLY 3             |     P=0.214      P=0.020N*    P=0.541N     P=0.544     |P=0.485      P=0.529N     P=0.485N     P=0.564      |
|POLY 1.5           |     P=0.212      P=0.014N*    P=0.517N     P=0.578     |P=0.522      P=0.453N     P=0.471N     P=0.595N     |
|POLY 6             |     P=0.209      P=0.028N*    P=0.569N     P=0.502     |P=0.438      P=0.588      P=0.513N     P=0.481      |
|LOGISTIC REGRESSION|     P=0.173      P=0.034N*    P=0.577N     P=0.472     |P=0.489      P=0.538N     P=0.494N     P=0.586      |
|COCH-ARM / FISHERS |     P=0.202      P=0.008N**   P=0.479N     P=0.567N    |P=0.558N     P=0.371N     P=0.465N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/48 (4%)    0/47 (0%)    0/49 (0%)    0/45 (0%)   |0/48 (0%)    0/49 (0%)    0/50 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/36 (6%)    0/21 (0%)    0/29 (0%)    0/26 (0%)   |0/41 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.265N     P=0.363N     P=0.287N     P=0.312N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.222N     P=0.284N     P=0.250N     P=0.272N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.231N     P=0.268N     P=0.243N     P=0.264N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.214N     P=0.301N     P=0.260N     P=0.282N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.265N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.249N     P=0.253N     P=0.242N     P=0.264N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/2 (0%)     0/0 (0%)     0/0 (0%)    |2/50 (4%)    2/50 (4%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.3%         5.4%         8.7%         7.9%         |
|TERMINAL (d)       |     0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)    |2/42 (5%)    0/13 (0%)    2/33 (6%)    2/21 (10%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      674          691          709          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.266      P=0.357      P=0.247      P=0.221      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.339      P=0.609      P=0.329      P=0.407      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.371      P=0.650      P=0.336      P=0.445      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.298      P=0.545      P=0.315      P=0.360      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.319      P=0.601      P=0.308      P=0.292      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.419      P=0.691N     P=0.339      P=0.500      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/4 (0%)     4/5 (80%)    1/5 (20%)    1/8 (13%)   |0/13 (0%)    4/8 (50%)    2/8 (25%)    1/4 (25%)    |
|POLY-3 ADJUSTED (b)|     0.0%         80.0%        26.9%        15.2%       |0.0%         52.7%        26.3%        28.1%        |
|TERMINAL (d)       |     0/4 (0%)     1/2 (50%)    1/2 (50%)    0/4 (0%)    |0/12 (0%)    0/2 (0%)     2/7 (29%)    1/2 (50%)    |
|FIRST INCIDENCE    |     ---          557          733 (T)      562         |---          514          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.436N     P=0.030 *    P=0.362      P=0.487     |P=0.575      P=0.024 *    P=0.125      P=0.154      |
|POLY 3             |     P=0.224N     P=0.006 **   P=0.485      P=0.601     |P=0.365      P=0.002 **   P=0.115      P=0.236      |
|POLY 1.5           |     P=0.194N     P=0.006 **   P=0.512      P=0.616     |P=0.390      P=0.003 **   P=0.117      P=0.243      |
|POLY 6             |     P=0.276N     P=0.006 **   P=0.445      P=0.580     |P=0.321      P=0.002 **   P=0.113      P=0.225      |
|LOGISTIC REGRESSION|     P=0.147N     (e)          P=0.362      P=0.992     |P=0.384      P=0.110      P=0.125      P=0.154      |
|COCH-ARM / FISHERS |     P=0.211N     P=0.040 *    P=0.556      P=0.667     |P=0.420      P=0.012 *    P=0.133      P=0.235      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/4 (100%)   1/5 (20%)    4/5 (80%)    4/8 (50%)   |10/13 (77%)  3/8 (38%)    6/8 (75%)    3/4 (75%)    |
|POLY-3 ADJUSTED (b)|     100.0%       26.2%        80.0%        63.1%       |79.8%        49.1%        75.0%        75.0%        |
|TERMINAL (d)       |     4/4 (100%)   1/2 (50%)    1/2 (50%)    3/4 (75%)   |10/12 (83%)  2/2 (100%)   5/7 (71%)    1/2 (50%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      562          648         |735 (T)      686          617          645          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.478      P=0.362N     P=0.338      P=0.740     |P=0.448      P=0.228      P=0.678N     P=0.432      |
|POLY 3             |     P=0.457N     P=0.019N*    P=0.544N     P=0.226N    |P=0.654      P=0.196N     P=0.611N     P=0.686N     |
|POLY 1.5           |     P=0.423N     P=0.009N**   P=0.544N     P=0.167N    |P=0.590      P=0.131N     P=0.632N     P=0.698N     |
|POLY 6             |     P=0.511N     P=0.055N     P=0.544N     P=0.357N    |P=0.623N     P=0.348N     P=0.581N     P=0.666N     |
|LOGISTIC REGRESSION|     P=0.546N     P=0.362N     (e)          P=0.596N    |P=0.506      P=0.722      P=0.687N     P=0.709      |
|COCH-ARM / FISHERS |     P=0.402N     P=0.040N*    P=0.556N     P=0.141N    |P=0.505      P=0.090N     P=0.656N     P=0.700N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    5/50 (10%)   4/49 (8%)    5/50 (10%)  |7/50 (14%)   7/50 (14%)   7/50 (14%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.6%         12.7%        9.5%         12.0%       |14.7%        18.8%        15.1%        5.3%         |
|TERMINAL (d)       |     2/36 (6%)    4/24 (17%)   2/29 (7%)    4/27 (15%)  |5/42 (12%)   4/13 (31%)   4/33 (12%)   2/21 (10%)   |
|FIRST INCIDENCE    |     590          687          669          648         |593          671          672          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.312      P=0.185      P=0.393      P=0.229     |P=0.145N     P=0.052      P=0.467      P=0.302N     |
|POLY 3             |     P=0.358      P=0.278      P=0.454      P=0.308     |P=0.090N     P=0.418      P=0.589      P=0.147N     |
|POLY 1.5           |     P=0.379      P=0.311      P=0.473      P=0.332     |P=0.072N     P=0.510      P=0.604      P=0.115N     |
|POLY 6             |     P=0.329      P=0.248      P=0.433      P=0.280     |P=0.123N     P=0.289      P=0.560      P=0.199N     |
|LOGISTIC REGRESSION|     P=0.368      P=0.278      P=0.506      P=0.328     |P=0.085N     P=0.354      P=0.613      P=0.117N     |
|COCH-ARM / FISHERS |     P=0.404      P=0.369      P=0.500      P=0.369     |P=0.051N     P=0.613N     P=0.613N     P=0.080N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    4/50 (8%)    2/49 (4%)    1/50 (2%)   |6/50 (12%)   1/50 (2%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     4.4%         10.2%        4.8%         2.4%        |12.8%        2.7%         6.5%         5.2%         |
|TERMINAL (d)       |     2/36 (6%)    3/24 (13%)   2/29 (7%)    1/27 (4%)   |5/42 (12%)   0/13 (0%)    2/33 (6%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      715          733 (T)      733 (T)     |715          657          728          669          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.287N     P=0.175      P=0.615      P=0.600N    |P=0.405N     P=0.379N     P=0.369N     P=0.410N     |
|POLY 3             |     P=0.262N     P=0.275      P=0.664      P=0.530N    |P=0.263N     P=0.103N     P=0.253N     P=0.208N     |
|POLY 1.5           |     P=0.248N     P=0.301      P=0.676      P=0.515N    |P=0.261N     P=0.078N     P=0.245N     P=0.175N     |
|POLY 6             |     P=0.281N     P=0.251      P=0.648      P=0.549N    |P=0.265N     P=0.154N     P=0.271N     P=0.256N     |
|LOGISTIC REGRESSION|     P=0.282N     P=0.212      P=0.615      P=0.600N    |P=0.334N     P=0.162N     P=0.312N     P=0.246N     |
|COCH-ARM / FISHERS |     P=0.231N     P=0.349      P=0.691N     P=0.492N    |P=0.254N     P=0.056N     P=0.243N     P=0.134N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |3/50 (6%)    3/50 (6%)    10/50 (20%)  2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |6.4%         8.0%         21.8%        5.3%         |
|TERMINAL (d)       |     0/36 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |3/42 (7%)    0/13 (0%)    9/33 (27%)   2/21 (10%)   |
|FIRST INCIDENCE    |     561          ---          ---          ---         |735 (T)      671          699          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.475N     P=0.531N     P=0.513N     P=0.513N    |P=0.572      P=0.241      P=0.012 *    P=0.565      |
|POLY 3             |     P=0.447N     P=0.530N     P=0.519N     P=0.520N    |P=0.506N     P=0.556      P=0.031 *    P=0.594N     |
|POLY 1.5           |     P=0.456N     P=0.518N     P=0.511N     P=0.510N    |P=0.452N     P=0.607      P=0.034 *    P=0.555N     |
|POLY 6             |     P=0.438N     P=0.543N     P=0.529N     P=0.532N    |P=0.578      P=0.478      P=0.027 *    P=0.642N     |
|LOGISTIC REGRESSION|     P=0.466N     P=0.289N     P=0.251N     P=0.282N    |P=0.530N     P=0.512      P=0.017 *    P=0.565      |
|COCH-ARM / FISHERS |     P=0.472N     P=0.495N     P=0.500N     P=0.495N    |P=0.380N     P=0.661N     P=0.036 *    P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    2/50 (4%)    3/49 (6%)    4/50 (8%)   |28/50 (56%)  17/50 (34%)  27/50 (54%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     8.8%         5.1%         7.2%         9.4%        |58.6%        42.2%        56.9%        34.9%        |
|TERMINAL (d)       |     3/36 (8%)    2/24 (8%)    2/29 (7%)    1/27 (4%)   |25/42 (60%)  5/13 (39%)   21/33 (64%)  6/21 (29%)   |
|FIRST INCIDENCE    |     561          733 (T)      672          608         |593          533          547          496          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.374      P=0.513N     P=0.600N     P=0.523     |P=0.250N     P=0.063      P=0.232      P=0.452N     |
|POLY 3             |     P=0.443      P=0.410N     P=0.549N     P=0.602     |P=0.037N*    P=0.088N     P=0.516N     P=0.019N*    |
|POLY 1.5           |     P=0.447      P=0.379N     P=0.529N     P=0.622     |P=0.027N*    P=0.045N*    P=0.494N     P=0.009N**   |
|POLY 6             |     P=0.436      P=0.443N     P=0.573N     P=0.579     |P=0.056N     P=0.200N     P=0.566N     P=0.045N*    |
|LOGISTIC REGRESSION|     P=0.438      P=0.385N     P=0.506N     P=0.565N    |P=0.055N     P=0.162N     P=0.533N     P=0.033N*    |
|COCH-ARM / FISHERS |     P=0.447      P=0.329N     P=0.500N     P=0.631N    |P=0.017N*    P=0.022N*    P=0.500N     P=0.004N**   |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/47 (4%)    2/46 (4%)    0/44 (0%)    1/47 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         5.6%         0.0%         2.8%         |
|TERMINAL (d)       |                                                        |2/39 (5%)    1/13 (8%)    0/29 (0%)    1/20 (5%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      426          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.479N     P=0.391      P=0.306N     P=0.726N     |
|POLY 3             |                                                        |P=0.406N     P=0.616      P=0.258N     P=0.567N     |
|POLY 1.5           |                                                        |P=0.396N     P=0.651      P=0.254N     P=0.539N     |
|POLY 6             |                                                        |P=0.419N     P=0.557      P=0.267N     P=0.602N     |
|LOGISTIC REGRESSION|                                                        |P=0.360N     P=0.651N     (e)          P=0.726N     |
|COCH-ARM / FISHERS |                                                        |P=0.379N     P=0.683      P=0.264N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |12/47 (26%)  9/46 (20%)   11/44 (25%)  9/47 (19%)   |
|POLY-3 ADJUSTED (b)|                                                        |27.0%        24.6%        26.7%        23.6%        |
|TERMINAL (d)       |                                                        |11/39 (28%)  3/13 (23%)   7/29 (24%)   2/20 (10%)   |
|FIRST INCIDENCE    |                                                        |517          533          589          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.453      P=0.126      P=0.435      P=0.353      |
|POLY 3             |                                                        |P=0.443N     P=0.505N     P=0.586N     P=0.462N     |
|POLY 1.5           |                                                        |P=0.407N     P=0.420N     P=0.574N     P=0.398N     |
|POLY 6             |                                                        |P=0.486N     P=0.570      P=0.583      P=0.542N     |
|LOGISTIC REGRESSION|                                                        |P=0.393N     P=0.440N     P=0.573N     P=0.360N     |
|COCH-ARM / FISHERS |                                                        |P=0.348N     P=0.330N     P=0.573N     P=0.311N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/47 (0%)    1/46 (2%)    1/44 (2%)    2/47 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         2.8%         2.5%         5.4%         |
|TERMINAL (d)       |                                                        |0/39 (0%)    0/13 (0%)    1/29 (3%)    0/20 (0%)    |
|FIRST INCIDENCE    |                                                        |---          645          735 (T)      608          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.140      P=0.445      P=0.441      P=0.185      |
|POLY 3             |                                                        |P=0.164      P=0.456      P=0.482      P=0.201      |
|POLY 1.5           |                                                        |P=0.178      P=0.475      P=0.485      P=0.215      |
|POLY 6             |                                                        |P=0.147      P=0.427      P=0.474      P=0.184      |
|LOGISTIC REGRESSION|                                                        |P=0.232      P=0.531      P=0.441      P=0.288      |
|COCH-ARM / FISHERS |                                                        |P=0.198      P=0.495      P=0.484      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/49 (4%)    2/47 (4%)   |1/50 (2%)    0/49 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.5%         0.0%         4.8%         4.9%        |2.1%         0.0%         2.2%         5.2%         |
|TERMINAL (d)       |     2/37 (5%)    0/24 (0%)    1/29 (3%)    1/27 (4%)   |1/42 (2%)    0/13 (0%)    1/33 (3%)    1/21 (5%)    |
|FIRST INCIDENCE    |     726          ---          681          715         |735 (T)      ---          735 (T)      650          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.503      P=0.205N     P=0.606N     P=0.634N    |P=0.149      P=0.733N     P=0.707      P=0.304      |
|POLY 3             |     P=0.565      P=0.151N     P=0.544N     P=0.560N    |P=0.215      P=0.548N     P=0.756      P=0.431      |
|POLY 1.5           |     P=0.560      P=0.138N     P=0.530N     P=0.546N    |P=0.222      P=0.527N     P=0.759      P=0.459      |
|POLY 6             |     P=0.563      P=0.165N     P=0.562N     P=0.579N    |P=0.207      P=0.580N     P=0.748      P=0.395      |
|LOGISTIC REGRESSION|     P=0.524      P=0.180N     P=0.571N     P=0.608N    |P=0.186      (e)          P=0.707      P=0.439      |
|COCH-ARM / FISHERS |     P=0.543      P=0.121N     P=0.510N     P=0.530N    |P=0.234      P=0.505N     P=0.753N     P=0.500      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/47 (4%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         5.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    2/27 (7%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.033 *    (e)          (e)          P=0.172     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.036 *    (e)          (e)          P=0.208     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.036 *    (e)          (e)          P=0.215     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.035 *    (e)          (e)          P=0.199     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.172     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.037 *    (e)          (e)          P=0.232     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    1/47 (2%)    1/45 (2%)    0/50 (0%)   |16/50 (32%)  15/50 (30%)  21/48 (44%)  15/49 (31%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.7%         2.6%         0.0%        |34.0%        38.6%        47.2%        38.5%        |
|TERMINAL (d)       |     0/36 (0%)    1/23 (4%)    1/27 (4%)    0/27 (0%)   |15/42 (36%)  8/13 (62%)   18/32 (56%)  9/21 (43%)   |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |678          589          658          487          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.564N     P=0.411      P=0.443      (e)         |P=0.171      P=0.002 **   P=0.033 *    P=0.051      |
|POLY 3             |     P=0.555N     P=0.464      P=0.469      (e)         |P=0.420      P=0.415      P=0.140      P=0.419      |
|POLY 1.5           |     P=0.542N     P=0.476      P=0.476      (e)         |P=0.490      P=0.538      P=0.155      P=0.512      |
|POLY 6             |     P=0.571N     P=0.452      P=0.460      (e)         |P=0.333      P=0.246      P=0.113      P=0.309      |
|LOGISTIC REGRESSION|     (e)          P=0.411      P=0.443      (e)         |P=0.333      P=0.168      P=0.080      P=0.305      |
|COCH-ARM / FISHERS |     P=0.524N     P=0.495      P=0.484      (e)         |P=0.504N     P=0.500N     P=0.161      P=0.527N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pleura: Mesothelium                                                                                                              |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     19/19 (100%) 4/4 (100%)   6/6 (100%)  |0/0 (0%)     16/16 (100%) 3/3 (100%)   13/13 (100%) |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       100.0%       100.0%      |0.0%         100.0%       100.0%       100.0%       |
|TERMINAL (d)       |     0/0 (0%)     12/12 (100%) 2/2 (100%)   5/5 (100%)  |0/0 (0%)     3/3 (100%)   2/2 (100%)   5/5 (100%)   |
|FIRST INCIDENCE    |     ---          504          664          706         |---          514          681          493          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     25/50 (50%)  21/50 (42%)  19/50 (38%)  20/49 (41%) |                                                    |
|POLY-3 ADJUSTED (b)|     53.1%        50.8%        43.2%        48.9%       |                                                    |
|TERMINAL (d)       |     22/37 (60%)  13/24 (54%)  12/29 (41%)  16/27 (59%) |                                                    |
|FIRST INCIDENCE    |     607          562          562          685         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.532N     P=0.228      P=0.493N     P=0.439     |                                                    |
|POLY 3             |     P=0.407N     P=0.499N     P=0.227N     P=0.426N    |                                                    |
|POLY 1.5           |     P=0.351N     P=0.414N     P=0.197N     P=0.340N    |                                                    |
|POLY 6             |     P=0.498N     P=0.574N     P=0.265N     P=0.543N    |                                                    |
|LOGISTIC REGRESSION|     P=0.424N     P=0.559      P=0.295N     P=0.585     |                                                    |
|COCH-ARM / FISHERS |     P=0.300N     P=0.274N     P=0.157N     P=0.237N    |                                                    |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   0/50 (0%)    3/50 (6%)    0/49 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     10.8%        0.0%         7.1%         0.0%        |                                                    |
|TERMINAL (d)       |     5/37 (14%)   0/24 (0%)    2/29 (7%)    0/27 (0%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      ---          657          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.104N     P=0.082N     P=0.488N     P=0.066N    |                                                    |
|POLY 3             |     P=0.071N     P=0.047N*    P=0.403N     P=0.043N*   |                                                    |
|POLY 1.5           |     P=0.072N     P=0.040N*    P=0.384N     P=0.038N*   |                                                    |
|POLY 6             |     P=0.072N     P=0.055N     P=0.427N     P=0.049N*   |                                                    |
|LOGISTIC REGRESSION|     P=0.098N     (e)          P=0.451N     (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.080N     P=0.028N*    P=0.357N     P=0.030N*   |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.3%         2.5%         4.7%         0.0%        |0.0%         0.0%         0.0%         2.6%         |
|TERMINAL (d)       |     2/37 (5%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      687          682          ---         |---          ---          ---          650          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.255N     P=0.615N     P=0.603      P=0.310N    |P=0.177      (e)          (e)          P=0.428      |
|POLY 3             |     P=0.218N     P=0.555N     P=0.663      P=0.262N    |P=0.198      (e)          (e)          P=0.460      |
|POLY 1.5           |     P=0.214N     P=0.535N     P=0.676      P=0.252N    |P=0.204      (e)          (e)          P=0.477      |
|POLY 6             |     P=0.227N     P=0.574N     P=0.647      P=0.275N    |P=0.190      (e)          (e)          P=0.440      |
|LOGISTIC REGRESSION|     P=0.226N     P=0.575N     P=0.646      (e)         |P=0.235      (e)          (e)          P=0.534      |
|COCH-ARM / FISHERS |     P=0.211N     P=0.500N     P=0.691N     P=0.247N    |P=0.214      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         7.0%         0.0%        |0.0%         5.4%         0.0%         2.6%         |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    1/13 (8%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          687          669          ---         |---          706          ---          650          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.551N     P=0.473      P=0.088      (e)         |P=0.552      P=0.057      (e)          P=0.428      |
|POLY 3             |     P=0.536N     P=0.468      P=0.105      (e)         |P=0.550      P=0.189      (e)          P=0.460      |
|POLY 1.5           |     P=0.520N     P=0.480      P=0.110      (e)         |P=0.581      P=0.211      (e)          P=0.477      |
|POLY 6             |     P=0.559N     P=0.457      P=0.099      (e)         |P=0.506      P=0.161      (e)          P=0.440      |
|LOGISTIC REGRESSION|     P=0.504N     P=0.497      P=0.120      (e)         |P=0.607      P=0.114      (e)          P=0.534      |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.121      (e)         |P=0.622      P=0.247      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         5.1%         7.0%         7.1%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/37 (3%)    1/24 (4%)    1/29 (3%)    1/27 (4%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      682          475          619         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.239      P=0.383      P=0.248      P=0.227     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.263      P=0.445      P=0.280      P=0.272     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.275      P=0.465      P=0.290      P=0.285     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.248      P=0.426      P=0.265      P=0.257     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.289      P=0.428      P=0.373      P=0.305     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.287      P=0.500      P=0.309      P=0.309     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Amyloid Deposition                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/48 (0%)    0/48 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          562          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.385N     P=0.180      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.412N     P=0.205      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.399N     P=0.217      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.427N     P=0.195      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.374N     P=0.279      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.377N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/48 (0%)    0/48 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.3%         5.1%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/37 (3%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     662          715          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.147N     P=0.554      P=0.289N     P=0.301N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.132N     P=0.632      P=0.265N     P=0.268N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.129N     P=0.655      P=0.258N     P=0.259N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.136N     P=0.607      P=0.276N     P=0.281N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.133N     P=0.635      P=0.240N     P=0.242N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.127N     P=0.691N     P=0.258N     P=0.258N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  34/50 (68%)  23/48 (48%)  29/48 (60%) |16/50 (32%)  36/49 (73%)  26/50 (52%)  21/49 (43%)  |
|POLY-3 ADJUSTED (b)|     29.4%        73.7%        50.6%        63.8%       |33.0%        79.4%        55.2%        47.8%        |
|TERMINAL (d)       |     8/37 (22%)   18/24 (75%)  10/29 (35%)  16/27 (59%) |13/42 (31%)  11/13 (85%)  20/33 (61%)  5/21 (24%)   |
|FIRST INCIDENCE    |     607          405          478          370         |264          426          617          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.046 *    P<0.001 **   P=0.019 *    P<0.001 **  |P=0.325      P<0.001 **   P=0.006 **   P=0.011 *    |
|POLY 3             |     P=0.035 *    P<0.001 **   P=0.028 *    P<0.001 **  |P=0.409N     P<0.001 **   P=0.021 *    P=0.106      |
|POLY 1.5           |     P=0.038 *    P<0.001 **   P=0.029 *    P<0.001 **  |P=0.358N     P<0.001 **   P=0.026 *    P=0.129      |
|POLY 6             |     P=0.029 *    P<0.001 **   P=0.028 *    P<0.001 **  |P=0.466N     P<0.001 **   P=0.015 *    P=0.084      |
|LOGISTIC REGRESSION|     P=0.051      P<0.001 **   P=0.058      P=0.002 **  |P=0.200N     P<0.001 **   P=0.034 *    P=0.326      |
|COCH-ARM / FISHERS |     P=0.048 *    P<0.001 **   P=0.034 *    P<0.001 **  |P=0.269N     P<0.001 **   P=0.034 *    P=0.182      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    4/48 (8%)    3/48 (6%)   |15/50 (30%)  3/49 (6%)    11/50 (22%)  14/49 (29%)  |
|POLY-3 ADJUSTED (b)|     0.0%         7.7%         9.8%         7.4%        |32.0%        8.1%         23.9%        36.9%        |
|TERMINAL (d)       |     0/37 (0%)    3/24 (13%)   4/29 (14%)   3/27 (11%)  |15/42 (36%)  1/13 (8%)    10/33 (30%)  13/21 (62%)  |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      733 (T)     |735 (T)      687          672          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.206      P=0.056      P=0.036 *    P=0.071     |P=0.013 *    P=0.276N     P=0.501N     P=0.026 *    |
|POLY 3             |     P=0.222      P=0.092      P=0.046 *    P=0.097     |P=0.105      P=0.007N**   P=0.260N     P=0.406      |
|POLY 1.5           |     P=0.238      P=0.101      P=0.050      P=0.103     |P=0.119      P=0.004N**   P=0.248N     P=0.509      |
|POLY 6             |     P=0.202      P=0.083      P=0.042 *    P=0.089     |P=0.089      P=0.020N*    P=0.288N     P=0.279      |
|LOGISTIC REGRESSION|     (e)          P=0.056      P=0.036 *    P=0.071     |P=0.030 *    P=0.088N     P=0.399N     P=0.093      |
|COCH-ARM / FISHERS |     P=0.257      P=0.121      P=0.054      P=0.114     |P=0.153      P=0.002N**   P=0.247N     P=0.526N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/48 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.7%        |0.0%         0.0%         4.3%         0.0%         |
|TERMINAL (d)       |     0/36 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          562         |---          ---          658          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.043 *    (e)          (e)          P=0.223     |P=0.729      (e)          P=0.229      (e)          |
|POLY 3             |     P=0.042 *    (e)          (e)          P=0.223     |P=0.701      (e)          P=0.235      (e)          |
|POLY 1.5           |     P=0.042 *    (e)          (e)          P=0.231     |P=0.721N     (e)          P=0.237      (e)          |
|POLY 6             |     P=0.041 *    (e)          (e)          P=0.215     |P=0.663      (e)          P=0.229      (e)          |
|LOGISTIC REGRESSION|     P=0.043 *    (e)          (e)          P=0.424     |P=0.684N     (e)          P=0.214      (e)          |
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.253     |P=0.695N     (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    3/48 (6%)    1/50 (2%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         5.0%         7.1%         2.4%        |0.0%         5.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/36 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     664          504          481          668         |---          580          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.549N     P=0.415      P=0.265      P=0.715     |P=0.410N     P=0.122      (e)          (e)          |
|POLY 3             |     P=0.538N     P=0.455      P=0.280      P=0.741     |P=0.426N     P=0.190      (e)          (e)          |
|POLY 1.5           |     P=0.523N     P=0.474      P=0.287      P=0.751     |P=0.400N     P=0.209      (e)          (e)          |
|POLY 6             |     P=0.559N     P=0.435      P=0.272      P=0.729     |P=0.462N     P=0.163      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.483N     P=0.639      P=0.507      P=0.726N    |P=0.336N     P=0.268      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.504N     P=0.508      P=0.301      P=0.747N    |P=0.367N     P=0.242      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    6/50 (12%)   8/48 (17%)   5/50 (10%)  |1/50 (2%)    4/49 (8%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     4.4%         14.8%        18.2%        11.6%       |2.1%         10.4%        8.6%         7.6%         |
|TERMINAL (d)       |     0/36 (0%)    2/24 (8%)    2/29 (7%)    1/27 (4%)   |1/42 (2%)    0/13 (0%)    1/33 (3%)    0/21 (0%)    |
|FIRST INCIDENCE    |     664          504          475          562         |735 (T)      533          658          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.346      P=0.069      P=0.036 *    P=0.155     |P=0.364      P=0.070      P=0.144      P=0.194      |
|POLY 3             |     P=0.372      P=0.099      P=0.039 *    P=0.194     |P=0.376      P=0.125      P=0.176      P=0.246      |
|POLY 1.5           |     P=0.390      P=0.113      P=0.041 *    P=0.206     |P=0.416      P=0.147      P=0.180      P=0.270      |
|POLY 6             |     P=0.348      P=0.088      P=0.038 *    P=0.181     |P=0.323      P=0.096      P=0.169      P=0.217      |
|LOGISTIC REGRESSION|     P=0.449      P=0.169      P=0.129      P=0.328     |P=0.583N     P=0.256      P=0.176      P=0.412      |
|COCH-ARM / FISHERS |     P=0.415      P=0.141      P=0.042 *    P=0.226     |P=0.474      P=0.175      P=0.181      P=0.309      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    2/48 (4%)    2/47 (4%)   |2/49 (4%)    0/49 (0%)    1/50 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         4.8%         5.0%        |4.3%         0.0%         2.2%         2.6%         |
|TERMINAL (d)       |     1/36 (3%)    0/24 (0%)    0/29 (0%)    1/27 (4%)   |2/42 (5%)    0/13 (0%)    1/33 (3%)    0/21 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          625          727         |735 (T)      ---          735 (T)      578          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.229      P=0.581N     P=0.454      P=0.402     |P=0.638      P=0.518N     P=0.584N     P=0.674N     |
|POLY 3             |     P=0.257      P=0.531N     P=0.472      P=0.461     |P=0.611N     P=0.292N     P=0.503N     P=0.566N     |
|POLY 1.5           |     P=0.257      P=0.520N     P=0.480      P=0.472     |P=0.616N     P=0.265N     P=0.496N     P=0.539N     |
|POLY 6             |     P=0.250      P=0.542N     P=0.464      P=0.447     |P=0.604N     P=0.338N     P=0.517N     P=0.600N     |
|LOGISTIC REGRESSION|     P=0.251      (e)          P=0.557      P=0.416     |P=0.638N     (e)          P=0.584N     P=0.494N     |
|COCH-ARM / FISHERS |     P=0.251      P=0.500N     P=0.492      P=0.484     |P=0.619N     P=0.247N     P=0.492N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    2/50 (4%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     12.8%        2.6%         4.7%         4.8%        |                                                    |
|TERMINAL (d)       |     4/37 (11%)   1/24 (4%)    1/29 (3%)    2/27 (7%)   |                                                    |
|FIRST INCIDENCE    |     615          733 (T)      650          733 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.318N     P=0.142N     P=0.218N     P=0.246N    |                                                    |
|POLY 3             |     P=0.239N     P=0.090N     P=0.166N     P=0.175N    |                                                    |
|POLY 1.5           |     P=0.240N     P=0.076N     P=0.152N     P=0.157N    |                                                    |
|POLY 6             |     P=0.243N     P=0.107N     P=0.185N     P=0.201N    |                                                    |
|LOGISTIC REGRESSION|     P=0.275N     P=0.084N     P=0.139N     P=0.171N    |                                                    |
|COCH-ARM / FISHERS |     P=0.251N     P=0.056N     P=0.134N     P=0.134N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.4%         4.8%        |                                                    |
|TERMINAL (d)       |     0/37 (0%)    0/24 (0%)    0/29 (0%)    2/27 (7%)   |                                                    |
|FIRST INCIDENCE    |     ---          ---          672          733 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.067      (e)          P=0.468      P=0.172     |                                                    |
|POLY 3             |     P=0.078      (e)          P=0.483      P=0.214     |                                                    |
|POLY 1.5           |     P=0.081      (e)          P=0.490      P=0.223     |                                                    |
|POLY 6             |     P=0.073      (e)          P=0.474      P=0.202     |                                                    |
|LOGISTIC REGRESSION|     P=0.076      (e)          P=0.535      P=0.172     |                                                    |
|COCH-ARM / FISHERS |     P=0.084      (e)          P=0.500      P=0.247     |                                                    |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/35 (0%)    0/39 (0%)    0/41 (0%)    0/35 (0%)   |0/47 (0%)    3/46 (7%)    3/42 (7%)    2/42 (5%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         8.8%         7.7%         6.3%         |
|TERMINAL (d)       |     0/28 (0%)    0/21 (0%)    0/27 (0%)    0/19 (0%)   |0/40 (0%)    2/13 (15%)   3/29 (10%)   2/20 (10%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          715          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.303      P=0.010 *    P=0.071      P=0.104      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.297      P=0.077      P=0.095      P=0.168      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.341      P=0.092      P=0.097      P=0.184      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.245      P=0.059      P=0.091      P=0.152      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.315      P=0.020 *    P=0.071      P=0.104      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.416      P=0.117      P=0.101      P=0.220      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Amyloid Deposition                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    2/48 (4%)    0/47 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    1/23 (4%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/20 (0%)    |
|FIRST INCIDENCE    |     ---          562          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.384N     P=0.175      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.399N     P=0.207      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.383N     P=0.219      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.417N     P=0.196      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.351N     P=0.284      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.359N     P=0.253      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/48 (0%)    0/47 (0%)    0/50 (0%)   |0/50 (0%)    2/49 (4%)    4/50 (8%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         5.4%         8.7%         2.7%         |
|TERMINAL (d)       |     0/37 (0%)    0/23 (0%)    0/29 (0%)    0/27 (0%)   |0/42 (0%)    1/13 (8%)    4/33 (12%)   1/20 (5%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          688          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.467      P=0.068      P=0.037 *    P=0.352      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.497      P=0.188      P=0.058      P=0.453      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.548      P=0.208      P=0.060      P=0.471      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.427      P=0.160      P=0.053      P=0.431      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.508      P=0.146      P=0.037 *    P=0.352      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.615      P=0.242      P=0.059      P=0.495      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/48 (0%)    0/47 (0%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    2/50 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.1%         0.0%         4.3%         0.0%         |
|TERMINAL (d)       |     0/37 (0%)    0/23 (0%)    0/29 (0%)    0/27 (0%)   |1/42 (2%)    0/13 (0%)    1/33 (3%)    0/20 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      ---          687          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.546N     P=0.733N     P=0.433      P=0.648N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.489N     P=0.548N     P=0.494      P=0.546N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.477N     P=0.527N     P=0.499      P=0.529N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.504N     P=0.580N     P=0.483      P=0.569N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.515N     (e)          P=0.496      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.459N     P=0.505N     P=0.500      P=0.505N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     2/2 (100%)   1/1 (100%)   0/2 (0%)    |0/1 (0%)     0/0 (0%)     2/2 (100%)   0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       100.0%       0.0%        |0.0%         0.0%         100.0%       0.0%         |
|TERMINAL (d)       |     0/0 (0%)     2/2 (100%)   1/1 (100%)   0/2 (0%)    |0/1 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)     |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      ---         |---          ---          687          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.098N     (e)          (e)          (e)         |P=0.636      (e)          P=0.217      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          P=1.000N     (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          P=1.000N     (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          P=1.000N     (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.074N     (e)          (e)          (e)         |P=0.807      (e)          P=0.333      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Malformation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/2 (0%)     0/1 (0%)     2/2 (100%)  |1/1 (100%)   0/0 (0%)     0/2 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         100.0%      |100.0%       0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/2 (0%)     0/1 (0%)     2/2 (100%)  |1/1 (100%)   0/0 (0%)     0/1 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |735 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.098      (e)          (e)          (e)         |P=0.841N     (e)          P=0.500N     (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          P<0.001N**   (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          P<0.001N**   (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.042N*    (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.841N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.074      (e)          (e)          (e)         |P=0.807N     (e)          P=0.333N     (e)          |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 48
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/48 (0%)    0/47 (0%)   |2/48 (4%)    1/49 (2%)    3/49 (6%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.6%         0.0%         0.0%        |4.4%         2.7%         6.7%         5.4%         |
|TERMINAL (d)       |     0/37 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)   |2/42 (5%)    0/13 (0%)    3/33 (9%)    2/21 (10%)   |
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |735 (T)      674          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.602N     P=0.414      (e)          (e)         |P=0.380      P=0.675      P=0.391      P=0.428      |
|POLY 3             |     P=0.611N     P=0.468      (e)          (e)         |P=0.477      P=0.575N     P=0.492      P=0.617      |
|POLY 1.5           |     P=0.602N     P=0.480      (e)          (e)         |P=0.499      P=0.537N     P=0.502      P=0.650      |
|POLY 6             |     P=0.620N     P=0.455      (e)          (e)         |P=0.445      P=0.631N     P=0.473      P=0.573      |
|LOGISTIC REGRESSION|     (e)          P=0.414      (e)          (e)         |P=0.431      P=0.636N     P=0.391      P=0.428      |
|COCH-ARM / FISHERS |     P=0.587N     P=0.500      (e)          (e)         |P=0.533      P=0.492N     P=0.510      P=0.692N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    3/49 (6%)    3/50 (6%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |2.1%         8.1%         6.5%         12.5%        |
|TERMINAL (d)       |                                                        |1/42 (2%)    0/13 (0%)    2/33 (6%)    1/21 (5%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      659          672          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.048 *    P=0.089      P=0.243      P=0.044 *    |
|POLY 3             |                                                        |P=0.074      P=0.228      P=0.299      P=0.069      |
|POLY 1.5           |                                                        |P=0.085      P=0.260      P=0.305      P=0.081      |
|POLY 6             |                                                        |P=0.061      P=0.186      P=0.289      P=0.056      |
|LOGISTIC REGRESSION|                                                        |P=0.125      P=0.236      P=0.300      P=0.149      |
|COCH-ARM / FISHERS |                                                        |P=0.104      P=0.301      P=0.309      P=0.102      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 49
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |8/50 (16%)   8/49 (16%)   8/50 (16%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |16.8%        21.1%        17.2%        12.6%        |
|TERMINAL (d)       |                                                        |6/42 (14%)   4/13 (31%)   7/33 (21%)   2/21 (10%)   |
|FIRST INCIDENCE    |                                                        |626          589          547          487          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.431N     P=0.055      P=0.440      P=0.587      |
|POLY 3             |                                                        |P=0.280N     P=0.412      P=0.588      P=0.401N     |
|POLY 1.5           |                                                        |P=0.247N     P=0.497      P=0.603      P=0.347N     |
|POLY 6             |                                                        |P=0.332N     P=0.292      P=0.556      P=0.476N     |
|LOGISTIC REGRESSION|                                                        |P=0.220N     P=0.442      P=0.607N     P=0.247N     |
|COCH-ARM / FISHERS |                                                        |P=0.201N     P=0.590      P=0.607N     P=0.277N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |38/50 (76%)  31/49 (63%)  36/50 (72%)  32/50 (64%)  |
|POLY-3 ADJUSTED (b)|                                                        |80.6%        71.5%        76.0%        74.1%        |
|TERMINAL (d)       |                                                        |36/42 (86%)  11/13 (85%)  27/33 (82%)  18/21 (86%)  |
|FIRST INCIDENCE    |                                                        |678          426          617          421          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.088      P<0.001 **   P=0.127      P=0.002 **   |
|POLY 3             |                                                        |P=0.399N     P=0.203N     P=0.380N     P=0.299N     |
|POLY 1.5           |                                                        |P=0.338N     P=0.146N     P=0.373N     P=0.217N     |
|POLY 6             |                                                        |P=0.470N     P=0.361N     P=0.419N     P=0.438N     |
|LOGISTIC REGRESSION|                                                        |P=0.536      P=0.513N     P=0.568      P=0.589      |
|COCH-ARM / FISHERS |                                                        |P=0.236N     P=0.123N     P=0.410N     P=0.138N     |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 50
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    0/49 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         0.0%         2.2%         5.1%         |
|TERMINAL (d)       |                                                        |0/42 (0%)    0/13 (0%)    0/33 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |                                                        |---          ---          729          510          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.061      (e)          P=0.458      P=0.211      |
|POLY 3             |                                                        |P=0.072      (e)          P=0.496      P=0.200      |
|POLY 1.5           |                                                        |P=0.077      (e)          P=0.499      P=0.215      |
|POLY 6             |                                                        |P=0.067      (e)          P=0.489      P=0.182      |
|LOGISTIC REGRESSION|                                                        |P=0.142      (e)          P=0.482      P=0.345      |
|COCH-ARM / FISHERS |                                                        |P=0.085      (e)          P=0.500      P=0.247      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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