TDMS Study 88124-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 02/22/00
EXPERIMENT: 88124 TEST: 04 TIME: 09:29:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: MILLER, R. CAS: 22398-80-7
------------------------------------------------------------------------------------------------------------------------------------
FINAL#2,
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 02/22/00
EXPERIMENT: 88124 TEST: 04 TIME: 09:29:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: MILLER, R. CAS: 22398-80-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF INDIUM PHOSPHIDE
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Adrenal Cortex Hypertrophy
Heart Cardiomyopathy
Heart: Artery Inflammation
Heart: Pericardium Inflammation
Intestine Small, Ileum: Peyer's Patch Hyperplasia
Islets, Pancreatic Hyperplasia
Kidney Inflammation Chronic
Metaplasia Osseous
Nephropathy
Kidney: Artery Inflammation
Larynx Inflammation
Liver Eosinophilic Focus
Lung Foreign Body
Inflammation Chronic
Lung: Alveolar Epithelium Hyperplasia
Lung: Alveolus Proteinosis
Lung: Serosa Fibrosis
Lymph Node, Bronchial Foreign Body
Hyperplasia
Lymph Node, Mediastinal Foreign Body
Hyperplasia
Lymph Node, Mesenteric Hyperplasia
Mesentery: Artery Inflammation
Mesentery: Fat Necrosis
Pancreas Hypertrophy
Preputial Gland Inflammation
Spleen Hematopoietic Cell Proliferation
Hyperplasia Lymphoid
Stomach, Forestomach Erosion
Stomach, Forestomach: Epithelium Hyperplasia
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Adrenal Cortex Hypertrophy
Adrenal Medulla Hyperplasia
Bone Fibrous Osteodystrophy
Bone Marrow Hyperplasia
Heart Cardiomyopathy
Heart: Artery Inflammation
Heart: Epicardium Inflammation
Heart: Pericardium Inflammation
Kidney Nephropathy
Kidney: Artery Inflammation
Larynx: Squamous Epithelium Hyperplasia
Liver Angiectasis
Eosinophilic Focus
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Northwest INDIUM PHOSPHIDE DATE: 02/22/00
EXPERIMENT: 88124 TEST: 04 TIME: 09:29:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C88124
PATHOLOGIST: MILLER, R. CAS: 22398-80-7
Lung Foreign Body
Inflammation Chronic
Lung: Alveolus Infiltration Cellular Histiocyte
Proteinosis
Lung: Bronchiole, Bronchus Degeneration Hyaline
Lung: Serosa Fibrosis
Lymph Node, Bronchial Foreign Body
Hyperplasia
Lymph Node, Mediastinal Foreign Body
Hyperplasia
Mesentery: Artery Inflammation
Nose: Olfactory Epithelium Degeneration Hyaline
Nose: Respiratory Epithelium Degeneration Hyaline
Pituitary Gland: Pars Distalis Hyperplasia
Spleen Hematopoietic Cell Proliferation
Hyperplasia Lymphoid
Thymus Hyperplasia Lymphoid
Thyroid Gland Inflammation
Tooth Malformation
Uterus Angiectasis
Hyperplasia Cystic
===============================================================
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Amyloid Deposition |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/48 (0%) 0/50 (0%) |2/50 (4%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.0% 0.0% 0.0% |4.3% 2.7% 0.0% 5.1% |
|TERMINAL (d) | 0/37 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |1/42 (2%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 562 --- --- |678 653 --- 594 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.385N P=0.180 (e) (e) |P=0.436 P=0.731 P=0.274N P=0.554 |
|POLY 3 | P=0.407N P=0.205 (e) (e) |P=0.495 P=0.580N P=0.243N P=0.623 |
|POLY 1.5 | P=0.392N P=0.217 (e) (e) |P=0.501 P=0.543N P=0.239N P=0.653 |
|POLY 6 | P=0.423N P=0.195 (e) (e) |P=0.488 P=0.635N P=0.252N P=0.584 |
|LOGISTIC REGRESSION| P=0.361N P=0.279 (e) (e) |P=0.562 P=0.516N P=0.238N P=0.647N |
|COCH-ARM / FISHERS | P=0.369N P=0.247 (e) (e) |P=0.512 P=0.500N P=0.247N P=0.691N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/48 (4%) 1/50 (2%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 2.2% 2.6% 4.9% 2.4% |0.0% 0.0% 0.0% 2.6% |
|TERMINAL (d) | 1/37 (3%) 1/24 (4%) 2/29 (7%) 1/27 (4%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) 733 (T) 733 (T) 733 (T) |--- --- --- 658 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.610 P=0.662 P=0.415 P=0.690 |P=0.175 (e) (e) P=0.421 |
|POLY 3 | P=0.638 P=0.723 P=0.459 P=0.736 |P=0.198 (e) (e) P=0.460 |
|POLY 1.5 | P=0.647N P=0.737 P=0.470 P=0.746 |P=0.204 (e) (e) P=0.476 |
|POLY 6 | P=0.621 P=0.708 P=0.446 P=0.723 |P=0.190 (e) (e) P=0.439 |
|LOGISTIC REGRESSION| P=0.610 P=0.662 P=0.415 P=0.690 |P=0.229 (e) (e) P=0.527 |
|COCH-ARM / FISHERS | P=0.639N P=0.753N P=0.485 P=0.753N |P=0.214 (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 15/50 (30%) 23/48 (48%) 19/50 (38%) |9/50 (18%) 7/50 (14%) 3/50 (6%) 10/50 (20%) |
|POLY-3 ADJUSTED (b)| 63.3% 37.6% 55.5% 45.2% |19.2% 18.8% 6.5% 25.7% |
|TERMINAL (d) | 25/37 (68%) 12/24 (50%) 20/29 (69%) 14/27 (52%) |9/42 (21%) 5/13 (39%) 2/33 (6%) 7/21 (33%) |
|FIRST INCIDENCE | 559 530 672 664 |735 (T) 687 685 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.406N P=0.135N P=0.527N P=0.289N |P=0.096 P=0.048 * P=0.129N P=0.055 |
|POLY 3 | P=0.178N P=0.011N* P=0.290N P=0.059N |P=0.244 P=0.590N P=0.063N P=0.325 |
|POLY 1.5 | P=0.161N P=0.005N** P=0.228N P=0.038N* |P=0.269 P=0.496N P=0.060N P=0.397 |
|POLY 6 | P=0.217N P=0.022N* P=0.386N P=0.098N |P=0.212 P=0.486 P=0.070N P=0.239 |
|LOGISTIC REGRESSION| P=0.291N P=0.025N* P=0.376N P=0.111N |P=0.165 P=0.165 P=0.088N P=0.251 |
|COCH-ARM / FISHERS | P=0.162N P=0.002N** P=0.159N P=0.022N* |P=0.308 P=0.393N P=0.061N P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 1/48 (2%) 6/49 (12%) |4/49 (8%) 5/49 (10%) 2/50 (4%) 3/49 (6%) |
|POLY-3 ADJUSTED (b)| 6.4% 5.1% 2.4% 14.5% |8.7% 13.6% 4.3% 7.9% |
|TERMINAL (d) | 2/37 (5%) 2/24 (8%) 0/29 (0%) 4/27 (15%) |4/41 (10%) 3/13 (23%) 1/33 (3%) 2/21 (10%) |
|FIRST INCIDENCE | 559 733 (T) 672 562 |735 (T) 700 589 705 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.053 P=0.669N P=0.374N P=0.145 |P=0.532N P=0.036 * P=0.422N P=0.470 |
|POLY 3 | P=0.065 P=0.579N P=0.351N P=0.186 |P=0.423N P=0.367 P=0.332N P=0.603N |
|POLY 1.5 | P=0.067 P=0.550N P=0.338N P=0.204 |P=0.396N P=0.429 P=0.328N P=0.561N |
|POLY 6 | P=0.061 P=0.609N P=0.366N P=0.166 |P=0.460N P=0.277 P=0.345N P=0.646 |
|LOGISTIC REGRESSION| P=0.068 P=0.541N P=0.258N P=0.272 |P=0.451N P=0.111 P=0.328N P=0.571 |
|COCH-ARM / FISHERS | P=0.070 P=0.500N P=0.324N P=0.233 |P=0.357N P=0.500 P=0.329N P=0.500N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Bone |
| Fibrous Osteodystrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/49 (0%) 2/50 (4%) 2/50 (4%) |11/50 (22%) 14/50 (28%) 14/50 (28%) 16/50 (32%) |
|POLY-3 ADJUSTED (b)| 4.4% 0.0% 4.7% 4.8% |23.5% 37.1% 30.4% 40.1% |
|TERMINAL (d) | 2/36 (6%) 0/23 (0%) 1/29 (3%) 2/27 (7%) |11/42 (26%) 8/13 (62%) 13/33 (39%) 9/21 (43%) |
|FIRST INCIDENCE | 733 (T) --- 678 733 (T) |735 (T) 671 672 510 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.372 P=0.341N P=0.617 P=0.588 |P=0.022 * P<0.001 ** P=0.120 P=0.003 ** |
|POLY 3 | P=0.431 P=0.276N P=0.671 P=0.663 |P=0.110 P=0.130 P=0.303 P=0.074 |
|POLY 1.5 | P=0.434 P=0.261N P=0.683 P=0.678 |P=0.144 P=0.209 P=0.318 P=0.111 |
|POLY 6 | P=0.422 P=0.292N P=0.655 P=0.642 |P=0.072 P=0.054 P=0.271 P=0.041 * |
|LOGISTIC REGRESSION| P=0.391 (e) P=0.654 P=0.588 |P=0.058 P=0.003 ** P=0.177 P=0.048 * |
|COCH-ARM / FISHERS | P=0.431 P=0.247N P=0.684N P=0.684N |P=0.205 P=0.322 P=0.322 P=0.184 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Bone Marrow |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |4.3% 0.0% 2.2% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |2/42 (5%) 0/13 (0%) 1/33 (3%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- --- --- |735 (T) --- 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.345N P=0.518N P=0.584N P=0.401N |
|POLY 3 | (e) (e) (e) (e) |P=0.263N P=0.294N P=0.508N P=0.287N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.268N P=0.266N P=0.502N P=0.265N |
|POLY 6 | (e) (e) (e) (e) |P=0.256N P=0.339N P=0.520N P=0.316N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.345N (e) P=0.584N (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.271N P=0.247N P=0.500N P=0.247N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 9/50 (18%) 6/50 (12%) 4/50 (8%) |6/50 (12%) 13/50 (26%) 5/50 (10%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 11.1% 21.5% 13.9% 9.5% |12.8% 31.9% 10.9% 17.7% |
|TERMINAL (d) | 4/36 (11%) 3/24 (13%) 3/29 (10%) 2/27 (7%) |5/42 (12%) 4/13 (31%) 4/33 (12%) 4/21 (19%) |
|FIRST INCIDENCE | 726 405 475 608 |678 426 681 493 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.305N P=0.079 P=0.370 P=0.613 |P=0.543 P<0.001 ** P=0.608 P=0.144 |
|POLY 3 | P=0.258N P=0.151 P=0.468 P=0.544N |P=0.471N P=0.025 * P=0.515N P=0.369 |
|POLY 1.5 | P=0.240N P=0.170 P=0.487 P=0.522N |P=0.417N P=0.040 * P=0.504N P=0.423 |
|POLY 6 | P=0.281N P=0.133 P=0.443 P=0.570N |P=0.546N P=0.011 * P=0.539N P=0.302 |
|LOGISTIC REGRESSION| P=0.205N P=0.290 P=0.491 P=0.555N |P=0.302N P=0.098 P=0.531N P=0.468 |
|COCH-ARM / FISHERS | P=0.216N P=0.205 P=0.514 P=0.487N |P=0.343N P=0.062 P=0.500N P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Brain: Meninges |
| Infiltration Cellular Mononuclear Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |2/50 (4%) 2/50 (4%) 2/50 (4%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.7% 0.0% |4.3% 5.4% 4.3% 5.1% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 2/29 (7%) 0/27 (0%) |2/42 (5%) 1/13 (8%) 1/33 (3%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- 733 (T) --- |735 (T) 630 664 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.730N (e) P=0.186 (e) |P=0.508 P=0.344 P=0.625 P=0.535 |
|POLY 3 | P=0.713N (e) P=0.218 (e) |P=0.571 P=0.609 P=0.688 P=0.627 |
|POLY 1.5 | P=0.706N (e) P=0.226 (e) |P=0.591 P=0.650 P=0.693 P=0.656 |
|POLY 6 | P=0.723 (e) P=0.207 (e) |P=0.541 P=0.544 P=0.678 P=0.589 |
|LOGISTIC REGRESSION| (e) (e) P=0.186 (e) |P=0.577N P=0.596 P=0.693 P=0.616N |
|COCH-ARM / FISHERS | P=0.697N (e) P=0.247 (e) |P=0.621 P=0.691N P=0.691N P=0.691N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Epididymis |
| Granuloma Sperm |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 2/50 (4%) | |
|POLY-3 ADJUSTED (b)| 4.3% 0.0% 0.0% 4.7% | |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) | |
|FIRST INCIDENCE | 662 --- --- 370 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.349 P=0.311N P=0.288N P=0.618 | |
|POLY 3 | P=0.398 P=0.277N P=0.259N P=0.660 | |
|POLY 1.5 | P=0.394 P=0.262N P=0.250N P=0.675 | |
|POLY 6 | P=0.398 P=0.294N P=0.272N P=0.639 | |
|LOGISTIC REGRESSION| P=0.395 P=0.243N P=0.227N P=0.504N | |
|COCH-ARM / FISHERS | P=0.381 P=0.247N P=0.247N P=0.691N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) 2/50 (4%) | |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% 2.4% 4.8% | |
|TERMINAL (d) | 1/37 (3%) 0/24 (0%) 0/29 (0%) 1/27 (4%) | |
|FIRST INCIDENCE | 733 (T) --- 682 533 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.205 P=0.586N P=0.701 P=0.420 | |
|POLY 3 | P=0.233 P=0.532N P=0.741 P=0.467 | |
|POLY 1.5 | P=0.234 P=0.520N P=0.749 P=0.481 | |
|POLY 6 | P=0.228 P=0.544N P=0.731 P=0.451 | |
|LOGISTIC REGRESSION| P=0.235 (e) P=0.752 P=0.570 | |
|COCH-ARM / FISHERS | P=0.231 P=0.500N P=0.753N P=0.500 | |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Eye |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 1/1 (100%) 2/3 (67%) 0/1 (0%) |0/0 (0%) 0/0 (0%) 1/1 (100%) 0/0 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 66.7% 0.0% |0.0% 0.0% 100.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 1/1 (100%) 0/1 (0%) 0/1 (0%) |0/0 (0%) 0/0 (0%) 1/1 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- 733 (T) 669 --- |--- --- 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.472N (e) P=0.191 (e) |(e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.315N (e) P=1.000 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Gallbladder |
| Degeneration Hyaline |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/43 (0%) 1/43 (2%) 0/41 (0%) 2/38 (5%) |0/46 (0%) 1/45 (2%) 0/48 (0%) 0/43 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.9% 0.0% 6.0% |0.0% 3.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/22 (0%) 0/28 (0%) 0/24 (0%) |0/42 (0%) 0/12 (0%) 0/32 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 687 --- 664 |--- 688 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.129 P=0.473 (e) P=0.189 |P=0.612N P=0.353 (e) (e) |
|POLY 3 | P=0.117 P=0.465 (e) P=0.194 |P=0.625N P=0.446 (e) (e) |
|POLY 1.5 | P=0.122 P=0.478 (e) P=0.201 |P=0.608N P=0.469 (e) (e) |
|POLY 6 | P=0.112 P=0.451 (e) P=0.185 |P=0.646N P=0.414 (e) (e) |
|LOGISTIC REGRESSION| P=0.126 P=0.505 (e) P=0.233 |P=0.586N P=0.499 (e) (e) |
|COCH-ARM / FISHERS | P=0.126 P=0.500 (e) P=0.217 |P=0.588N P=0.495 (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Gallbladder |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/43 (0%) 1/43 (2%) 1/41 (2%) 0/38 (0%) |2/46 (4%) 2/45 (4%) 3/48 (6%) 0/43 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.9% 2.8% 0.0% |4.5% 5.8% 6.8% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/22 (0%) 1/28 (4%) 0/24 (0%) |2/42 (5%) 0/12 (0%) 3/32 (9%) 0/21 (0%) |
|FIRST INCIDENCE | --- 687 733 (T) --- |735 (T) 548 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.584N P=0.473 P=0.444 (e) |P=0.245N P=0.384 P=0.377 P=0.401N |
|POLY 3 | P=0.588N P=0.465 P=0.475 (e) |P=0.219N P=0.598 P=0.497 P=0.298N |
|POLY 1.5 | P=0.577N P=0.478 P=0.481 (e) |P=0.200N P=0.640 P=0.510 P=0.277N |
|POLY 6 | P=0.602N P=0.451 P=0.467 (e) |P=0.249N P=0.534 P=0.475 P=0.328N |
|LOGISTIC REGRESSION| P=0.568N P=0.505 P=0.444 (e) |P=0.189N P=0.673N P=0.377 (e) |
|COCH-ARM / FISHERS | P=0.565N P=0.500 P=0.488 (e) |P=0.180N P=0.683 P=0.520 P=0.264N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 39/50 (78%) 41/50 (82%) 42/50 (84%) 41/50 (82%) |45/50 (90%) 39/50 (78%) 46/50 (92%) 38/50 (76%) |
|POLY-3 ADJUSTED (b)| 80.7% 92.1% 90.5% 90.2% |94.9% 87.1% 95.6% 86.8% |
|TERMINAL (d) | 31/37 (84%) 24/24 (100%) 29/29 (100%) 27/27 (100%)|42/42 (100%) 13/13 (100%) 33/33 (100%) 21/21 (100%) |
|FIRST INCIDENCE | 559 405 475 370 |664 514 658 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.094 P=0.002 ** P=0.017 * P=0.010 * |P=0.065 P<0.001 ** P=0.007 ** P<0.001 ** |
|POLY 3 | P=0.217 P=0.074 P=0.122 P=0.134 |P=0.171N P=0.113N P=0.661 P=0.109N |
|POLY 1.5 | P=0.325 P=0.173 P=0.191 P=0.237 |P=0.137N P=0.084N P=0.615 P=0.073N |
|POLY 6 | P=0.087 P=0.022 * P=0.059 P=0.050 |P=0.234N P=0.228N P=0.710 P=0.216N |
|LOGISTIC REGRESSION| P=0.309 P=0.046 * P=0.083 P=0.088 |P=0.579N P=0.478 P=0.279 P=0.638 |
|COCH-ARM / FISHERS | P=0.434 P=0.402 P=0.306 P=0.402 |P=0.096N P=0.086N P=0.500 P=0.054N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Heart |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.7% 2.4% |0.0% 0.0% 4.3% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- 657 645 |--- --- 658 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.320 (e) P=0.195 P=0.466 |P=0.730 (e) P=0.224 (e) |
|POLY 3 | P=0.333 (e) P=0.220 P=0.480 |P=0.702 (e) P=0.235 (e) |
|POLY 1.5 | P=0.341 (e) P=0.227 P=0.488 |P=0.722N (e) P=0.237 (e) |
|POLY 6 | P=0.320 (e) P=0.212 P=0.470 |P=0.665 (e) P=0.229 (e) |
|LOGISTIC REGRESSION| P=0.356 (e) P=0.270 P=0.572 |P=0.690N (e) P=0.215 (e) |
|COCH-ARM / FISHERS | P=0.350 (e) P=0.247 P=0.500 |P=0.697N (e) P=0.247 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Heart: Artery |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 18/50 (36%) 14/50 (28%) 10/50 (20%) |1/50 (2%) 16/50 (32%) 11/50 (22%) 13/50 (26%) |
|POLY-3 ADJUSTED (b)| 6.4% 40.6% 30.6% 22.9% |2.1% 38.3% 23.8% 31.2% |
|TERMINAL (d) | 2/37 (5%) 6/24 (25%) 6/29 (21%) 5/27 (19%) |0/42 (0%) 2/13 (15%) 10/33 (30%) 6/21 (29%) |
|FIRST INCIDENCE | 559 405 475 370 |593 426 617 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.387 P<0.001 ** P=0.002 ** P=0.016 * |P=0.019 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P=0.407 P<0.001 ** P=0.002 ** P=0.024 * |P=0.025 * P<0.001 ** P=0.002 ** P<0.001 ** |
|POLY 1.5 | P=0.448 P<0.001 ** P=0.002 ** P=0.029 * |P=0.038 * P<0.001 ** P=0.002 ** P<0.001 ** |
|POLY 6 | P=0.354 P<0.001 ** P=0.002 ** P=0.020 * |P=0.013 * P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.559N P=0.002 ** P=0.013 * P=0.081 |P=0.119 P<0.001 ** P=0.003 ** P=0.002 ** |
|COCH-ARM / FISHERS | P=0.499 P<0.001 ** P=0.003 ** P=0.036 * |P=0.073 P<0.001 ** P=0.002 ** P<0.001 ** |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Heart: Atrium |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |1/50 (2%) 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 0.0% 4.8% |2.1% 2.7% 2.2% 2.6% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 421 --- 706 |593 686 617 594 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.141 P=0.488 (e) P=0.188 |P=0.627 P=0.670 P=0.758N P=0.722 |
|POLY 3 | P=0.137 P=0.472 (e) P=0.215 |P=0.622 P=0.703 P=0.755 P=0.712 |
|POLY 1.5 | P=0.142 P=0.482 (e) P=0.224 |P=0.640 P=0.731 P=0.759 P=0.733 |
|POLY 6 | P=0.129 P=0.461 (e) P=0.204 |P=0.596 P=0.658 P=0.748 P=0.684 |
|LOGISTIC REGRESSION| P=0.157 P=0.985 (e) P=0.211 |P=0.578N P=0.715N P=0.701 P=0.687N |
|COCH-ARM / FISHERS | P=0.151 P=0.500 (e) P=0.247 |P=0.667 P=0.753N P=0.753N P=0.753N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Heart: Epicardium |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |1/50 (2%) 5/50 (10%) 0/50 (0%) 7/50 (14%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.1% 2.4% 0.0% |2.1% 12.9% 0.0% 17.5% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 1/13 (8%) 0/33 (0%) 2/21 (10%) |
|FIRST INCIDENCE | --- 687 625 --- |699 533 --- 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.408N P=0.200 P=0.491 (e) |P=0.015 * P=0.028 * P=0.535N P=0.007 ** |
|POLY 3 | P=0.419N P=0.204 P=0.484 (e) |P=0.018 * P=0.064 P=0.505N P=0.016 * |
|POLY 1.5 | P=0.402N P=0.216 P=0.490 (e) |P=0.022 * P=0.080 P=0.501N P=0.021 * |
|POLY 6 | P=0.439N P=0.194 P=0.475 (e) |P=0.013 * P=0.044 * P=0.512N P=0.011 * |
|LOGISTIC REGRESSION| P=0.373N P=0.217 P=0.612 (e) |P=0.065 P=0.164 P=0.503N P=0.048 * |
|COCH-ARM / FISHERS | P=0.378N P=0.247 P=0.500 (e) |P=0.032 * P=0.102 P=0.500N P=0.030 * |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Heart: Pericardium |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 6/50 (12%) 0/50 (0%) 5/50 (10%) |0/50 (0%) 9/50 (18%) 0/50 (0%) 4/50 (8%) |
|POLY-3 ADJUSTED (b)| 0.0% 14.8% 0.0% 12.0% |0.0% 22.7% 0.0% 10.5% |
|TERMINAL (d) | 0/37 (0%) 2/24 (8%) 0/29 (0%) 3/27 (11%) |0/42 (0%) 1/13 (8%) 0/33 (0%) 3/21 (14%) |
|FIRST INCIDENCE | --- 562 --- 668 |--- 533 --- 695 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.115 P=0.008 ** (e) P=0.016 * |P=0.383 P<0.001 ** (e) P=0.012 * |
|POLY 3 | P=0.108 P=0.009 ** (e) P=0.023 * |P=0.388 P<0.001 ** (e) P=0.038 * |
|POLY 1.5 | P=0.120 P=0.011 * (e) P=0.026 * |P=0.446 P<0.001 ** (e) P=0.047 * |
|POLY 6 | P=0.095 P=0.008 ** (e) P=0.020 * |P=0.315 P<0.001 ** (e) P=0.030 * |
|LOGISTIC REGRESSION| P=0.143 P=0.018 * (e) P=0.022 * |P=0.564 P=0.005 ** (e) P=0.022 * |
|COCH-ARM / FISHERS | P=0.146 P=0.013 * (e) P=0.028 * |P=0.527 P<0.001 ** (e) P=0.059 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Intestine Small, Ileum: Peyer's Patch |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/45 (11%) 0/47 (0%) 0/43 (0%) 1/45 (2%) |2/46 (4%) 0/48 (0%) 0/50 (0%) 1/48 (2%) |
|POLY-3 ADJUSTED (b)| 11.7% 0.0% 0.0% 2.5% |4.5% 0.0% 0.0% 2.7% |
|TERMINAL (d) | 4/37 (11%) 0/24 (0%) 0/29 (0%) 1/27 (4%) |2/42 (5%) 0/13 (0%) 0/33 (0%) 1/21 (5%) |
|FIRST INCIDENCE | 590 --- --- 733 (T) |735 (T) --- --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.230N P=0.081N P=0.056N P=0.181N |P=0.655 P=0.518N P=0.293N P=0.733 |
|POLY 3 | P=0.165N P=0.040N* P=0.042N* P=0.121N |P=0.614N P=0.288N P=0.230N P=0.557N |
|POLY 1.5 | P=0.174N P=0.034N* P=0.038N* P=0.112N |P=0.628N P=0.258N P=0.224N P=0.525N |
|POLY 6 | P=0.157N P=0.048N* P=0.046N* P=0.136N |P=0.593N P=0.336N P=0.242N P=0.599N |
|LOGISTIC REGRESSION| P=0.201N P=0.031N* P=0.034N* P=0.104N |P=0.655 (e) (e) P=0.733 |
|COCH-ARM / FISHERS | P=0.197N P=0.025N* P=0.031N* P=0.101N |P=0.645N P=0.237N P=0.227N P=0.484N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 1/50 (2%) 3/49 (6%) 4/47 (9%) |2/50 (4%) 0/49 (0%) 2/50 (4%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 17.2% 2.5% 7.2% 9.9% |4.2% 0.0% 4.4% 2.6% |
|TERMINAL (d) | 6/37 (16%) 0/24 (0%) 3/29 (10%) 3/27 (11%) |0/42 (0%) 0/13 (0%) 2/33 (6%) 1/21 (5%) |
|FIRST INCIDENCE | 590 687 733 (T) 715 |664 --- 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.517N P=0.065N P=0.190N P=0.351N |P=0.608 P=0.400N P=0.631 P=0.685N |
|POLY 3 | P=0.426N P=0.030N* P=0.137N P=0.253N |P=0.610N P=0.298N P=0.683 P=0.575N |
|POLY 1.5 | P=0.434N P=0.024N* P=0.123N P=0.233N |P=0.604N P=0.270N P=0.690 P=0.544N |
|POLY 6 | P=0.428N P=0.038N* P=0.157N P=0.281N |P=0.617N P=0.344N P=0.668 P=0.614N |
|LOGISTIC REGRESSION| P=0.485N P=0.031N* P=0.148N P=0.268N |P=0.653N P=0.223N P=0.695 P=0.539N |
|COCH-ARM / FISHERS | P=0.461N P=0.015N* P=0.106N P=0.210N |P=0.593N P=0.253N P=0.691N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney |
| Amyloid Deposition |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/49 (0%) 2/50 (4%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.0% 0.0% 4.7% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 562 --- 533 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.275 P=0.180 (e) P=0.217 |(e) (e) (e) (e) |
|POLY 3 | P=0.261 P=0.205 (e) P=0.219 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.272 P=0.217 (e) P=0.226 |(e) (e) (e) (e) |
|POLY 6 | P=0.249 P=0.195 (e) P=0.210 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.300 P=0.279 (e) P=0.414 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.288 P=0.247 (e) P=0.247 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 12
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/49 (0%) 0/50 (0%) |0/50 (0%) 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.3% 2.5% 0.0% 0.0% |0.0% 0.0% 2.2% 0.0% |
|TERMINAL (d) | 2/37 (5%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) 700 --- --- |--- --- 547 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.196N P=0.625N P=0.293N P=0.310N |P=0.805N (e) P=0.508 (e) |
|POLY 3 | P=0.166N P=0.555N P=0.260N P=0.262N |P=0.781 (e) P=0.498 (e) |
|POLY 1.5 | P=0.167N P=0.535N P=0.253N P=0.252N |P=0.795N (e) P=0.500 (e) |
|POLY 6 | P=0.167N P=0.575N P=0.271N P=0.275N |P=0.754 (e) P=0.493 (e) |
|LOGISTIC REGRESSION| P=0.185N P=0.585N (e) (e) |P=0.690N (e) P=0.361 (e) |
|COCH-ARM / FISHERS | P=0.170N P=0.500N P=0.253N P=0.247N |P=0.785N (e) P=0.500 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/49 (0%) 2/50 (4%) |1/50 (2%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 4.8% |2.1% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 1/27 (4%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- --- 671 |593 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.034 * (e) (e) P=0.184 |P=0.489N P=0.547N P=0.500N P=0.536N |
|POLY 3 | P=0.040 * (e) (e) P=0.215 |P=0.437N P=0.550N P=0.506N P=0.543N |
|POLY 1.5 | P=0.040 * (e) (e) P=0.224 |P=0.454N P=0.529N P=0.502N P=0.525N |
|POLY 6 | P=0.038 * (e) (e) P=0.205 |P=0.413N P=0.583N P=0.514N P=0.566N |
|LOGISTIC REGRESSION| P=0.040 * (e) (e) P=0.222 |P=0.406N P=0.459N P=0.588N P=0.426N |
|COCH-ARM / FISHERS | P=0.042 * (e) (e) P=0.247 |P=0.473N P=0.505N P=0.500N P=0.500N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 13
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney |
| Metaplasia Osseous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 0/50 (0%) 2/49 (4%) 1/50 (2%) |2/50 (4%) 3/49 (6%) 4/50 (8%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 10.8% 0.0% 4.8% 2.4% |4.3% 8.1% 8.7% 5.2% |
|TERMINAL (d) | 4/37 (11%) 0/24 (0%) 2/29 (7%) 1/27 (4%) |1/42 (2%) 1/13 (8%) 3/33 (9%) 1/21 (5%) |
|FIRST INCIDENCE | 726 --- 733 (T) 733 (T) |715 645 685 633 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.265N P=0.084N P=0.325N P=0.190N |P=0.549 P=0.178 P=0.250 P=0.482 |
|POLY 3 | P=0.192N P=0.047N* P=0.259N P=0.128N |P=0.589N P=0.396 P=0.328 P=0.619 |
|POLY 1.5 | P=0.196N P=0.040N* P=0.245N P=0.117N |P=0.555N P=0.441 P=0.336 P=0.651 |
|POLY 6 | P=0.192N P=0.055N P=0.279N P=0.144N |P=0.558 P=0.331 P=0.314 P=0.577 |
|LOGISTIC REGRESSION| P=0.261N P=0.068N P=0.320N P=0.174N |P=0.567N P=0.418 P=0.321 P=0.647 |
|COCH-ARM / FISHERS | P=0.211N P=0.028N* P=0.226N P=0.102N |P=0.503N P=0.490 P=0.339 P=0.691N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 40/50 (80%) 41/49 (84%) 41/50 (82%) |37/50 (74%) 30/49 (61%) 43/50 (86%) 36/50 (72%) |
|POLY-3 ADJUSTED (b)| 95.9% 86.8% 88.8% 90.4% |76.9% 70.8% 89.5% 82.8% |
|TERMINAL (d) | 36/37 (97%) 22/24 (92%) 28/29 (97%) 27/27 (100%)|34/42 (81%) 9/13 (69%) 31/33 (94%) 18/21 (86%) |
|FIRST INCIDENCE | 561 405 475 562 |264 514 617 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.334 P=0.092 P=0.300 P=0.152 |P=0.009 ** P<0.001 ** P=0.003 ** P<0.001 ** |
|POLY 3 | P=0.434N P=0.088N P=0.148N P=0.217N |P=0.162 P=0.329N P=0.071 P=0.320 |
|POLY 1.5 | P=0.309N P=0.062N P=0.117N P=0.122N |P=0.237 P=0.221N P=0.085 P=0.452 |
|POLY 6 | P=0.573 P=0.119N P=0.221N P=0.463N |P=0.106 P=0.517N P=0.055 P=0.198 |
|LOGISTIC REGRESSION| P=0.261N P=0.213N P=0.270N P=0.424N |P=0.095 P=0.427N P=0.093 P=0.263 |
|COCH-ARM / FISHERS | P=0.212N P=0.036N* P=0.094N P=0.061N |P=0.420 P=0.126N P=0.105 P=0.500N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 14
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney: Artery |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 5/50 (10%) 6/49 (12%) 2/50 (4%) |0/50 (0%) 0/49 (0%) 1/50 (2%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 12.5% 14.2% 4.8% |0.0% 0.0% 2.2% 7.6% |
|TERMINAL (d) | 0/37 (0%) 3/24 (13%) 4/29 (14%) 1/27 (4%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 504 491 685 |--- --- 617 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.563 P=0.012 * P=0.010 * P=0.183 |P=0.013 * (e) P=0.504 P=0.085 |
|POLY 3 | P=0.573 P=0.020 * P=0.011 * P=0.215 |P=0.017 * (e) P=0.497 P=0.091 |
|POLY 1.5 | P=0.592N P=0.023 * P=0.012 * P=0.224 |P=0.019 * (e) P=0.500 P=0.102 |
|POLY 6 | P=0.533 P=0.017 * P=0.010 * P=0.204 |P=0.016 * (e) P=0.492 P=0.079 |
|LOGISTIC REGRESSION| P=0.559N P=0.027 * P=0.017 * P=0.213 |P=0.055 (e) P=0.436 P=0.191 |
|COCH-ARM / FISHERS | P=0.551N P=0.028 * P=0.012 * P=0.247 |P=0.022 * (e) P=0.500 P=0.121 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney: Capsule |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/49 (4%) 0/50 (0%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 4.7% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- 491 --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.703N (e) P=0.223 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.712N (e) P=0.220 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.705N (e) P=0.225 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.722 (e) P=0.214 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.691N (e) P=0.467 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.697N (e) P=0.242 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 15
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 3/49 (6%) 5/50 (10%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 10.7% 5.1% 7.2% 12.1% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/37 (8%) 2/24 (8%) 3/29 (10%) 5/27 (19%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 590 733 (T) 733 (T) 733 (T) |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.278 P=0.391N P=0.489N P=0.441 |(e) (e) (e) (e) |
|POLY 3 | P=0.354 P=0.294N P=0.422N P=0.552 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.364 P=0.264N P=0.399N P=0.584 |(e) (e) (e) (e) |
|POLY 6 | P=0.334 P=0.329N P=0.452N P=0.508 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.312 P=0.270N P=0.400N P=0.548 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.368 P=0.218N P=0.369N P=0.630N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Larynx |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/49 (6%) 1/49 (2%) 4/50 (8%) |0/50 (0%) 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 10.5% 7.7% 2.4% 9.7% |0.0% 2.7% 2.2% 5.2% |
|TERMINAL (d) | 1/37 (3%) 1/24 (4%) 0/29 (0%) 4/27 (15%) |0/42 (0%) 1/13 (8%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 559 574 650 733 (T) |--- 735 (T) 729 695 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.534 P=0.522N P=0.151N P=0.614 |P=0.132 P=0.267 P=0.458 P=0.139 |
|POLY 3 | P=0.586 P=0.465N P=0.132N P=0.585N |P=0.155 P=0.453 P=0.496 P=0.195 |
|POLY 1.5 | P=0.592N P=0.429N P=0.121N P=0.550N |P=0.170 P=0.475 P=0.499 P=0.212 |
|POLY 6 | P=0.563 P=0.501N P=0.148N P=0.629N |P=0.135 P=0.420 P=0.489 P=0.176 |
|LOGISTIC REGRESSION| P=0.581N P=0.254N P=0.043N* P=0.475N |P=0.148 P=0.267 P=0.482 P=0.199 |
|COCH-ARM / FISHERS | P=0.584N P=0.369N P=0.107N P=0.500N |P=0.194 P=0.500 P=0.500 P=0.247 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 16
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Larynx: Squamous Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 3/49 (6%) 4/49 (8%) 7/50 (14%) |9/50 (18%) 17/50 (34%) 10/50 (20%) 15/50 (30%) |
|POLY-3 ADJUSTED (b)| 12.8% 7.4% 9.2% 15.7% |19.2% 40.8% 21.3% 35.3% |
|TERMINAL (d) | 4/37 (11%) 0/24 (0%) 0/29 (0%) 1/27 (4%) |9/42 (21%) 4/13 (31%) 6/33 (18%) 2/21 (10%) |
|FIRST INCIDENCE | 590 405 478 370 |735 (T) 426 617 487 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.215 P=0.404N P=0.479N P=0.360 |P=0.091 P<0.001 ** P=0.321 P=0.009 ** |
|POLY 3 | P=0.260 P=0.320N P=0.420N P=0.460 |P=0.194 P=0.020 * P=0.501 P=0.068 |
|POLY 1.5 | P=0.261 P=0.295N P=0.405N P=0.478 |P=0.220 P=0.033 * P=0.507 P=0.085 |
|POLY 6 | P=0.252 P=0.345N P=0.439N P=0.434 |P=0.169 P=0.009 ** P=0.486 P=0.053 |
|LOGISTIC REGRESSION| P=0.287 P=0.092N P=0.236N P=0.416N |P=0.332 P=0.063 P=0.489 P=0.127 |
|COCH-ARM / FISHERS | P=0.253 P=0.254N P=0.383N P=0.500 |P=0.277 P=0.055 P=0.500 P=0.121 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Amyloid Deposition |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 562 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.385N P=0.180 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.406N P=0.205 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.392N P=0.217 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.422N P=0.195 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.361N P=0.279 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.369N P=0.247 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 17
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% 0.0% 0.0% |0.0% 0.0% 2.2% 5.3% |
|TERMINAL (d) | 1/37 (3%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 1/33 (3%) 2/21 (10%) |
|FIRST INCIDENCE | 733 (T) --- --- --- |--- --- 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.499N P=0.586N P=0.549N P=0.563N |P=0.042 * (e) P=0.452 P=0.104 |
|POLY 3 | P=0.450N P=0.532N P=0.518N P=0.522N |P=0.068 (e) P=0.496 P=0.194 |
|POLY 1.5 | P=0.459N P=0.520N P=0.511N P=0.513N |P=0.074 (e) P=0.499 P=0.211 |
|POLY 6 | P=0.442N P=0.544N P=0.528N P=0.533N |P=0.061 (e) P=0.489 P=0.174 |
|LOGISTIC REGRESSION| P=0.499N (e) (e) (e) |(e) (e) P=0.452 P=0.104 |
|COCH-ARM / FISHERS | P=0.474N P=0.500N P=0.500N P=0.500N |P=0.084 (e) P=0.500 P=0.247 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |2/50 (4%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 4.3% 2.6% 4.7% 0.0% |4.3% 5.4% 0.0% 5.1% |
|TERMINAL (d) | 0/37 (0%) 1/24 (4%) 1/29 (3%) 0/27 (0%) |2/42 (5%) 1/13 (8%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 559 733 (T) 475 --- |735 (T) 645 --- 496 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.238N P=0.612N P=0.641 P=0.283N |P=0.529 P=0.341 P=0.293N P=0.543 |
|POLY 3 | P=0.220N P=0.561N P=0.663 P=0.265N |P=0.586 P=0.608 P=0.242N P=0.627 |
|POLY 1.5 | P=0.215N P=0.538N P=0.676 P=0.254N |P=0.599 P=0.650 P=0.239N P=0.655 |
|POLY 6 | P=0.229N P=0.584N P=0.645 P=0.280N |P=0.568 P=0.543 P=0.250N P=0.590 |
|LOGISTIC REGRESSION| P=0.200N P=0.469N P=0.498N P=0.146N |P=0.610N P=0.570 (e) P=0.625N |
|COCH-ARM / FISHERS | P=0.211N P=0.500N P=0.691N P=0.247N |P=0.618 P=0.691N P=0.247N P=0.691N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 18
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |2/50 (4%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 4.3% 2.6% 4.7% 0.0% |4.3% 0.0% 0.0% 5.2% |
|TERMINAL (d) | 2/37 (5%) 1/24 (4%) 2/29 (7%) 0/27 (0%) |2/42 (5%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) 733 (T) 733 (T) --- |735 (T) --- --- 695 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.251N P=0.650N P=0.605 P=0.310N |P=0.293 P=0.518N P=0.293N P=0.466 |
|POLY 3 | P=0.218N P=0.557N P=0.661 P=0.262N |P=0.386 P=0.294N P=0.242N P=0.618 |
|POLY 1.5 | P=0.214N P=0.536N P=0.675 P=0.252N |P=0.382 P=0.266N P=0.239N P=0.650 |
|POLY 6 | P=0.226N P=0.577N P=0.643 P=0.275N |P=0.393 P=0.339N P=0.250N P=0.575 |
|LOGISTIC REGRESSION| P=0.251N P=0.650N P=0.605 (e) |P=0.313 (e) (e) P=0.569 |
|COCH-ARM / FISHERS | P=0.211N P=0.500N P=0.691N P=0.247N |P=0.381 P=0.247N P=0.247N P=0.691N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 16/50 (32%) 19/50 (38%) 18/50 (36%) |6/50 (12%) 9/50 (18%) 4/50 (8%) 12/50 (24%) |
|POLY-3 ADJUSTED (b)| 21.3% 40.1% 43.9% 42.2% |12.7% 23.3% 8.7% 30.5% |
|TERMINAL (d) | 8/37 (22%) 13/24 (54%) 16/29 (55%) 14/27 (52%) |4/42 (10%) 2/13 (15%) 4/33 (12%) 9/21 (43%) |
|FIRST INCIDENCE | 590 574 491 589 |678 630 735 (T) 533 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.038 * P=0.009 ** P=0.007 ** P=0.008 ** |P=0.016 * P=0.014 * P=0.511N P=0.003 ** |
|POLY 3 | P=0.067 P=0.044 * P=0.016 * P=0.025 * |P=0.041 * P=0.159 P=0.388N P=0.037 * |
|POLY 1.5 | P=0.088 P=0.068 P=0.023 * P=0.036 * |P=0.054 P=0.214 P=0.376N P=0.056 |
|POLY 6 | P=0.045 * P=0.028 * P=0.009 ** P=0.016 * |P=0.028 * P=0.098 P=0.414N P=0.021 * |
|LOGISTIC REGRESSION| P=0.069 P=0.038 * P=0.018 * P=0.026 * |P=0.043 * P=0.169 P=0.401N P=0.035 * |
|COCH-ARM / FISHERS | P=0.119 P=0.127 P=0.038 * P=0.059 |P=0.081 P=0.288 P=0.370N P=0.096 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 19
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |3/50 (6%) 3/50 (6%) 4/50 (8%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% 0.0% 0.0% |6.3% 7.7% 8.6% 7.7% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |1/42 (2%) 0/13 (0%) 2/33 (6%) 1/21 (5%) |
|FIRST INCIDENCE | 669 --- --- --- |664 426 672 578 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.499N P=0.541N P=0.535N P=0.547N |P=0.477 P=0.473 P=0.433 P=0.453 |
|POLY 3 | P=0.449N P=0.533N P=0.519N P=0.523N |P=0.521 P=0.568 P=0.488 P=0.569 |
|POLY 1.5 | P=0.458N P=0.521N P=0.511N P=0.513N |P=0.554 P=0.614 P=0.497 P=0.608 |
|POLY 6 | P=0.441N P=0.546N P=0.530N P=0.534N |P=0.478 P=0.493 P=0.469 P=0.518 |
|LOGISTIC REGRESSION| P=0.471N P=0.477N P=0.460N P=0.464N |P=0.479N P=0.493N P=0.494 P=0.626N |
|COCH-ARM / FISHERS | P=0.474N P=0.500N P=0.500N P=0.500N |P=0.590N P=0.661N P=0.500 P=0.661N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 2/50 (4%) 7/50 (14%) |4/50 (8%) 3/50 (6%) 9/50 (18%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 8.5% 9.6% 4.7% 16.4% |8.5% 8.0% 19.5% 7.8% |
|TERMINAL (d) | 1/37 (3%) 0/24 (0%) 0/29 (0%) 1/27 (4%) |2/42 (5%) 0/13 (0%) 6/33 (18%) 0/21 (0%) |
|FIRST INCIDENCE | 607 504 678 501 |678 657 685 658 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.118 P=0.513 P=0.432N P=0.163 |P=0.509 P=0.383 P=0.063 P=0.534 |
|POLY 3 | P=0.125 P=0.573 P=0.385N P=0.207 |P=0.558N P=0.621N P=0.107 P=0.606N |
|POLY 1.5 | P=0.133 P=0.598 P=0.365N P=0.229 |P=0.518N P=0.565N P=0.114 P=0.563N |
|POLY 6 | P=0.113 P=0.547 P=0.411N P=0.182 |P=0.544 P=0.600 P=0.095 P=0.645 |
|LOGISTIC REGRESSION| P=0.157 P=0.308N P=0.253N P=0.337 |P=0.546N P=0.593N P=0.108 P=0.555N |
|COCH-ARM / FISHERS | P=0.143 P=0.643N P=0.339N P=0.262 |P=0.457N P=0.500N P=0.117 P=0.500N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 20
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Tension Lipidosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |2/50 (4%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 4.3% 2.6% 0.0% 0.0% |4.3% 2.7% 4.4% 2.6% |
|TERMINAL (d) | 2/37 (5%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |2/42 (5%) 0/13 (0%) 2/33 (6%) 1/21 (5%) |
|FIRST INCIDENCE | 733 (T) 733 (T) --- --- |735 (T) 580 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.195N P=0.650N P=0.293N P=0.310N |P=0.603N P=0.712 P=0.605 P=0.733 |
|POLY 3 | P=0.165N P=0.557N P=0.258N P=0.262N |P=0.516N P=0.577N P=0.686 P=0.572N |
|POLY 1.5 | P=0.166N P=0.536N P=0.249N P=0.252N |P=0.502N P=0.541N P=0.692 P=0.542N |
|POLY 6 | P=0.166N P=0.577N P=0.269N P=0.275N |P=0.535N P=0.630N P=0.674 P=0.610N |
|LOGISTIC REGRESSION| P=0.195N P=0.650N (e) (e) |P=0.532N P=0.498N P=0.605 P=0.733 |
|COCH-ARM / FISHERS | P=0.169N P=0.500N P=0.247N P=0.247N |P=0.479N P=0.500N P=0.691N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Liver |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |1/50 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 4.3% 0.0% 2.4% 0.0% |2.1% 0.0% 2.2% 0.0% |
|TERMINAL (d) | 2/37 (5%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) --- 625 --- |715 --- 699 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.299N P=0.338N P=0.561N P=0.310N |P=0.523N P=0.697N P=0.718 P=0.616N |
|POLY 3 | P=0.258N P=0.275N P=0.528N P=0.262N |P=0.466N P=0.547N P=0.756 P=0.542N |
|POLY 1.5 | P=0.261N P=0.261N P=0.517N P=0.252N |P=0.466N P=0.525N P=0.759 P=0.524N |
|POLY 6 | P=0.257N P=0.291N P=0.543N P=0.275N |P=0.466N P=0.580N P=0.749 P=0.564N |
|LOGISTIC REGRESSION| P=0.276N (e) P=0.498N (e) |P=0.490N P=0.587N P=0.762 P=0.552N |
|COCH-ARM / FISHERS | P=0.271N P=0.247N P=0.500N P=0.247N |P=0.464N P=0.500N P=0.753N P=0.500N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 21
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung |
| Foreign Body |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 49/50 (98%) 42/50 (84%) 49/50 (98%) |0/50 (0%) 49/50 (98%) 35/50 (70%) 49/50 (98%) |
|POLY-3 ADJUSTED (b)| 0.0% 99.7% 85.0% 98.0% |0.0% 98.0% 71.4% 98.0% |
|TERMINAL (d) | 0/37 (0%) 24/24 (100%) 23/29 (79%) 26/27 (96%) |0/42 (0%) 12/13 (92%) 22/33 (67%) 20/21 (95%) |
|FIRST INCIDENCE | --- 331 475 370 |--- 426 547 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 2/50 (4%) 2/50 (4%) |4/50 (8%) 3/50 (6%) 4/50 (8%) 4/50 (8%) |
|POLY-3 ADJUSTED (b)| 10.7% 2.5% 4.7% 4.8% |8.5% 7.9% 8.6% 9.8% |
|TERMINAL (d) | 3/37 (8%) 0/24 (0%) 2/29 (7%) 1/27 (4%) |4/42 (10%) 1/13 (8%) 2/33 (6%) 0/21 (0%) |
|FIRST INCIDENCE | 664 700 733 (T) 668 |735 (T) 589 617 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.416N P=0.197N P=0.318N P=0.340N |P=0.379 P=0.361 P=0.541 P=0.420 |
|POLY 3 | P=0.334N P=0.146N P=0.259N P=0.264N |P=0.481 P=0.613N P=0.639 P=0.563 |
|POLY 1.5 | P=0.335N P=0.128N P=0.241N P=0.244N |P=0.499 P=0.560N P=0.642N P=0.599 |
|POLY 6 | P=0.339N P=0.167N P=0.285N P=0.291N |P=0.455 P=0.611 P=0.626 P=0.514 |
|LOGISTIC REGRESSION| P=0.370N P=0.131N P=0.258N P=0.240N |P=0.508N P=0.552N P=0.644 P=0.435N |
|COCH-ARM / FISHERS | P=0.344N P=0.102N P=0.218N P=0.218N |P=0.521 P=0.500N P=0.643N P=0.643N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 22
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 50/50 (100%) 45/50 (90%) 46/50 (92%) |2/50 (4%) 49/50 (98%) 45/50 (90%) 50/50 (100%) |
|POLY-3 ADJUSTED (b)| 4.3% 100.0% 93.6% 95.5% |4.3% 98.4% 92.9% 100.0% |
|TERMINAL (d) | 2/37 (5%) 24/24 (100%) 28/29 (97%) 26/27 (96%) |2/42 (5%) 13/13 (100%) 33/33 (100%) 21/21 (100%) |
|FIRST INCIDENCE | 733 (T) 331 475 370 |735 (T) 426 617 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 3/50 (6%) 7/50 (14%) |0/50 (0%) 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 4.3% 12.8% 7.1% 16.9% |0.0% 2.7% 2.2% 5.3% |
|TERMINAL (d) | 2/37 (5%) 5/24 (21%) 3/29 (10%) 7/27 (26%) |0/42 (0%) 0/13 (0%) 1/33 (3%) 2/21 (10%) |
|FIRST INCIDENCE | 733 (T) 733 (T) 733 (T) 733 (T) |--- 514 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.046 * P=0.077 P=0.389 P=0.025 * |P=0.124 P=0.496 P=0.452 P=0.104 |
|POLY 3 | P=0.067 P=0.155 P=0.459 P=0.055 |P=0.153 P=0.457 P=0.496 P=0.194 |
|POLY 1.5 | P=0.076 P=0.177 P=0.476 P=0.064 |P=0.169 P=0.477 P=0.499 P=0.211 |
|POLY 6 | P=0.056 P=0.135 P=0.437 P=0.045 * |P=0.132 P=0.425 P=0.489 P=0.174 |
|LOGISTIC REGRESSION| P=0.046 * P=0.077 P=0.389 P=0.025 * |P=0.195 P=0.520 P=0.452 P=0.104 |
|COCH-ARM / FISHERS | P=0.089 P=0.218 P=0.500 P=0.080 |P=0.194 P=0.500 P=0.500 P=0.247 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 23
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 2/50 (4%) 2/50 (4%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 0.0% 0.0% |0.0% 5.4% 4.3% 7.9% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 1/13 (8%) 1/33 (3%) 3/21 (14%) |
|FIRST INCIDENCE | --- 706 --- --- |--- 686 691 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.592N P=0.434 (e) (e) |P=0.081 P=0.080 P=0.198 P=0.031 * |
|POLY 3 | P=0.602N P=0.468 (e) (e) |P=0.108 P=0.190 P=0.233 P=0.086 |
|POLY 1.5 | P=0.592N P=0.480 (e) (e) |P=0.127 P=0.211 P=0.237 P=0.098 |
|POLY 6 | P=0.611N P=0.457 (e) (e) |P=0.086 P=0.161 P=0.226 P=0.072 |
|LOGISTIC REGRESSION| P=0.584N P=0.472 (e) (e) |P=0.099 P=0.149 P=0.237 P=0.031 * |
|COCH-ARM / FISHERS | P=0.576N P=0.500 (e) (e) |P=0.156 P=0.247 P=0.247 P=0.121 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Proteinosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 14/50 (28%) 0/50 (0%) 10/50 (20%) |0/50 (0%) 31/50 (62%) 0/50 (0%) 8/50 (16%) |
|POLY-3 ADJUSTED (b)| 0.0% 35.1% 0.0% 22.7% |0.0% 74.0% 0.0% 19.4% |
|TERMINAL (d) | 0/37 (0%) 12/24 (50%) 0/29 (0%) 5/27 (19%) |0/42 (0%) 13/13 (100%) 0/33 (0%) 3/21 (14%) |
|FIRST INCIDENCE | --- 504 --- 370 |--- 514 --- 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.052 P<0.001 ** (e) P<0.001 ** |P=0.321N P<0.001 ** (e) P<0.001 ** |
|POLY 3 | P=0.047 * P<0.001 ** (e) P<0.001 ** |P=0.154N P<0.001 ** (e) P=0.002 ** |
|POLY 1.5 | P=0.056 P<0.001 ** (e) P<0.001 ** |P=0.105N P<0.001 ** (e) P=0.003 ** |
|POLY 6 | P=0.038 * P<0.001 ** (e) P<0.001 ** |P=0.250N P<0.001 ** (e) P<0.001 ** |
|LOGISTIC REGRESSION| P=0.084 P<0.001 ** (e) P=0.004 ** |P=0.072N P<0.001 ** (e) P=0.017 * |
|COCH-ARM / FISHERS | P=0.084 P<0.001 ** (e) P<0.001 ** |P=0.122N P<0.001 ** (e) P=0.003 ** |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 24
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Artery, Mediastinum |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/50 (4%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.1% 4.7% 0.0% |0.0% 0.0% 2.2% 0.0% |
|TERMINAL (d) | 0/37 (0%) 2/24 (8%) 1/29 (3%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 1/33 (3%) 0/21 (0%) |
|FIRST INCIDENCE | --- 733 (T) 491 --- |--- --- 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.417N P=0.149 P=0.207 (e) |P=0.798 (e) P=0.452 (e) |
|POLY 3 | P=0.424N P=0.203 P=0.221 (e) |P=0.782 (e) P=0.496 (e) |
|POLY 1.5 | P=0.406N P=0.215 P=0.228 (e) |P=0.796N (e) P=0.499 (e) |
|POLY 6 | P=0.448N P=0.191 P=0.212 (e) |P=0.756 (e) P=0.489 (e) |
|LOGISTIC REGRESSION| P=0.377N P=0.149 P=0.369 (e) |(e) (e) P=0.452 (e) |
|COCH-ARM / FISHERS | P=0.381N P=0.247 P=0.247 (e) |P=0.786N (e) P=0.500 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Bronchiole, Bronchus |
| Degeneration Hyaline |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 5.3% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 1/21 (5%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 727 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.022 * (e) (e) P=0.113 |
|POLY 3 | (e) (e) (e) (e) |P=0.036 * (e) (e) P=0.194 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.037 * (e) (e) P=0.211 |
|POLY 6 | (e) (e) (e) (e) |P=0.034 * (e) (e) P=0.174 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.024 * (e) (e) P=0.134 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.042 * (e) (e) P=0.247 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 25
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Interstitium |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.1% 0.0% 0.0% |0.0% 2.7% 0.0% 5.1% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 687 --- --- |--- 727 --- 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.400N P=0.209 (e) (e) |P=0.126 P=0.295 (e) P=0.222 |
|POLY 3 | P=0.407N P=0.204 (e) (e) |P=0.127 P=0.453 (e) P=0.201 |
|POLY 1.5 | P=0.392N P=0.216 (e) (e) |P=0.137 P=0.475 (e) P=0.215 |
|POLY 6 | P=0.423N P=0.194 (e) (e) |P=0.114 P=0.421 (e) P=0.182 |
|LOGISTIC REGRESSION| P=0.370N P=0.225 (e) (e) |P=0.255 P=0.352 (e) P=0.367 |
|COCH-ARM / FISHERS | P=0.369N P=0.247 (e) (e) |P=0.151 P=0.500 (e) P=0.247 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lung: Serosa |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 50/50 (100%) 49/50 (98%) 50/50 (100%)|0/50 (0%) 50/50 (100%) 47/50 (94%) 49/50 (98%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 99.4% 100.0% |0.0% 100.0% 96.5% 98.0% |
|TERMINAL (d) | 0/37 (0%) 24/24 (100%) 29/29 (100%) 27/27 (100%)|0/42 (0%) 13/13 (100%) 33/33 (100%) 20/21 (95%) |
|FIRST INCIDENCE | --- 331 475 370 |--- 426 617 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 26
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Bronchial |
| Foreign Body |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 43/48 (90%) 40/45 (89%) 40/48 (83%) |0/36 (0%) 44/50 (88%) 33/48 (69%) 40/50 (80%) |
|POLY-3 ADJUSTED (b)| 0.0% 90.6% 90.8% 85.5% |0.0% 89.6% 71.2% 81.5% |
|TERMINAL (d) | 0/30 (0%) 21/24 (88%) 22/24 (92%) 22/27 (82%) |0/29 (0%) 11/13 (85%) 22/32 (69%) 16/21 (76%) |
|FIRST INCIDENCE | --- 331 475 370 |--- 426 617 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Bronchial |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/35 (6%) 36/48 (75%) 22/45 (49%) 22/48 (46%) |5/36 (14%) 42/50 (84%) 31/48 (65%) 28/50 (56%) |
|POLY-3 ADJUSTED (b)| 5.9% 76.6% 54.8% 52.7% |14.8% 88.2% 67.4% 60.5% |
|TERMINAL (d) | 1/30 (3%) 17/24 (71%) 14/24 (58%) 17/27 (63%) |5/29 (17%) 12/13 (92%) 22/32 (69%) 12/21 (57%) |
|FIRST INCIDENCE | 664 331 475 562 |735 (T) 426 617 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.117 P<0.001 ** P<0.001 ** P<0.001 ** |P=0.029 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P=0.123 P<0.001 ** P<0.001 ** P<0.001 ** |P=0.221 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P=0.196 P<0.001 ** P<0.001 ** P<0.001 ** |P=0.250 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P=0.061 P<0.001 ** P<0.001 ** P<0.001 ** |P=0.186 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.368 P<0.001 ** P<0.001 ** P<0.001 ** |P=0.429 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P=0.349 P<0.001 ** P<0.001 ** P<0.001 ** |P=0.311 P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 27
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Bronchial: Artery |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 0/48 (0%) 0/45 (0%) 1/48 (2%) |0/36 (0%) 2/50 (4%) 1/48 (2%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.5% |0.0% 5.3% 2.3% 2.6% |
|TERMINAL (d) | 0/30 (0%) 0/24 (0%) 0/24 (0%) 1/27 (4%) |0/29 (0%) 1/13 (8%) 0/32 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- --- 733 (T) |--- 589 687 705 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.217 (e) (e) P=0.479 |P=0.575 P=0.139 P=0.481 P=0.400 |
|POLY 3 | P=0.230 (e) (e) P=0.535 |P=0.597 P=0.258 P=0.554 P=0.524 |
|POLY 1.5 | P=0.234 (e) (e) P=0.547 |P=0.627 P=0.282 P=0.556 P=0.541 |
|POLY 6 | P=0.223 (e) (e) P=0.519 |P=0.557 P=0.225 P=0.550 P=0.504 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.479 |P=0.659N P=0.347 P=0.561 P=0.529 |
|COCH-ARM / FISHERS | P=0.237 (e) (e) P=0.578 |P=0.661N P=0.335 P=0.571 P=0.581 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/28 (4%) 2/32 (6%) 1/33 (3%) 0/36 (0%) |0/36 (0%) 0/36 (0%) 0/43 (0%) 1/42 (2%) |
|POLY-3 ADJUSTED (b)| 3.8% 7.8% 3.7% 0.0% |0.0% 0.0% 0.0% 3.1% |
|TERMINAL (d) | 1/21 (5%) 2/18 (11%) 1/18 (6%) 0/22 (0%) |0/30 (0%) 0/9 (0%) 0/28 (0%) 1/17 (6%) |
|FIRST INCIDENCE | 733 (T) 733 (T) 733 (T) --- |--- --- --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.209N P=0.445 P=0.728 P=0.491N |P=0.176 (e) (e) P=0.387 |
|POLY 3 | P=0.212N P=0.492 P=0.754N P=0.476N |P=0.217 (e) (e) P=0.492 |
|POLY 1.5 | P=0.203N P=0.511 P=0.741N P=0.466N |P=0.223 (e) (e) P=0.508 |
|POLY 6 | P=0.223N P=0.478 P=0.752 P=0.487N |P=0.209 (e) (e) P=0.471 |
|LOGISTIC REGRESSION| P=0.209N P=0.445 P=0.728 (e) |(e) (e) (e) P=0.387 |
|COCH-ARM / FISHERS | P=0.189N P=0.551 P=0.711N P=0.437N |P=0.234 (e) (e) P=0.538 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 28
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Foreign Body |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 24/49 (49%) 14/45 (31%) 25/48 (52%) |0/42 (0%) 20/48 (42%) 7/46 (15%) 16/49 (33%) |
|POLY-3 ADJUSTED (b)| 0.0% 54.2% 34.3% 56.9% |0.0% 48.2% 16.5% 36.8% |
|TERMINAL (d) | 0/31 (0%) 7/23 (30%) 8/27 (30%) 16/27 (59%) |0/37 (0%) 3/12 (25%) 4/29 (14%) 7/21 (33%) |
|FIRST INCIDENCE | --- 405 491 370 |--- 426 658 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.008 ** P<0.001 ** P=0.006 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.014 * P<0.001 ** P=0.009 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.020 * P<0.001 ** P=0.009 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.007 ** P<0.001 ** P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.175 P<0.001 ** P=0.012 * P=0.002 ** |
|COCH-ARM / FISHERS | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.041 * P<0.001 ** P=0.008 ** P<0.001 ** |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 34/49 (69%) 17/45 (38%) 27/48 (56%) |2/42 (5%) 40/48 (83%) 11/46 (24%) 29/49 (59%) |
|POLY-3 ADJUSTED (b)| 0.0% 75.6% 41.9% 61.4% |5.0% 87.4% 25.7% 62.7% |
|TERMINAL (d) | 0/31 (0%) 17/23 (74%) 11/27 (41%) 17/27 (63%) |2/37 (5%) 10/12 (83%) 6/29 (21%) 12/21 (57%) |
|FIRST INCIDENCE | --- 331 562 370 |735 (T) 426 664 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.003 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.002 ** P<0.001 ** P=0.004 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.002 ** P<0.001 ** P=0.009 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.002 ** P<0.001 ** P=0.010 * P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |P<0.001 ** P<0.001 ** P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P=0.006 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.068 P<0.001 ** P=0.012 * P<0.001 ** |
|COCH-ARM / FISHERS | P=0.006 ** P<0.001 ** P<0.001 ** P<0.001 ** |P=0.016 * P<0.001 ** P=0.011 * P<0.001 ** |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 29
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal: Artery |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 1/49 (2%) 2/45 (4%) 1/48 (2%) |0/42 (0%) 0/48 (0%) 0/46 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.6% 5.2% 2.5% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 1/23 (4%) 2/27 (7%) 1/27 (4%) |0/37 (0%) 0/12 (0%) 0/29 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 733 (T) 733 (T) 733 (T) |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.492 P=0.440 P=0.208 P=0.472 |(e) (e) (e) (e) |
|POLY 3 | P=0.502 P=0.507 P=0.246 P=0.516 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.515 P=0.520 P=0.254 P=0.524 |(e) (e) (e) (e) |
|POLY 6 | P=0.482 P=0.493 P=0.236 P=0.505 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.440 P=0.208 P=0.472 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.530 P=0.551 P=0.277 P=0.545 |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 11/48 (23%) 2/47 (4%) 10/49 (20%) 10/45 (22%) |8/48 (17%) 6/49 (12%) 7/50 (14%) 7/48 (15%) |
|POLY-3 ADJUSTED (b)| 24.7% 5.5% 23.4% 26.1% |17.6% 15.8% 15.1% 18.7% |
|TERMINAL (d) | 9/36 (25%) 2/21 (10%) 6/29 (21%) 9/26 (35%) |7/41 (17%) 0/13 (0%) 4/33 (12%) 4/21 (19%) |
|FIRST INCIDENCE | 669 733 (T) 625 645 |678 617 672 533 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.152 P=0.067N P=0.488 P=0.374 |P=0.347 P=0.210 P=0.568 P=0.268 |
|POLY 3 | P=0.214 P=0.020N* P=0.541N P=0.544 |P=0.485 P=0.529N P=0.485N P=0.564 |
|POLY 1.5 | P=0.212 P=0.014N* P=0.517N P=0.578 |P=0.522 P=0.453N P=0.471N P=0.595N |
|POLY 6 | P=0.209 P=0.028N* P=0.569N P=0.502 |P=0.438 P=0.588 P=0.513N P=0.481 |
|LOGISTIC REGRESSION| P=0.173 P=0.034N* P=0.577N P=0.472 |P=0.489 P=0.538N P=0.494N P=0.586 |
|COCH-ARM / FISHERS | P=0.202 P=0.008N** P=0.479N P=0.567N |P=0.558N P=0.371N P=0.465N P=0.500N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 30
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 0/47 (0%) 0/49 (0%) 0/45 (0%) |0/48 (0%) 0/49 (0%) 0/50 (0%) 0/48 (0%) |
|POLY-3 ADJUSTED (b)| 4.5% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 0/21 (0%) 0/29 (0%) 0/26 (0%) |0/41 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) --- --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.265N P=0.363N P=0.287N P=0.312N |(e) (e) (e) (e) |
|POLY 3 | P=0.222N P=0.284N P=0.250N P=0.272N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.231N P=0.268N P=0.243N P=0.264N |(e) (e) (e) (e) |
|POLY 6 | P=0.214N P=0.301N P=0.260N P=0.282N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.265N (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.249N P=0.253N P=0.242N P=0.264N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/2 (0%) 0/0 (0%) 0/0 (0%) |2/50 (4%) 2/50 (4%) 4/50 (8%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |4.3% 5.4% 8.7% 7.9% |
|TERMINAL (d) | 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/0 (0%) |2/42 (5%) 0/13 (0%) 2/33 (6%) 2/21 (10%) |
|FIRST INCIDENCE | --- --- --- --- |735 (T) 674 691 709 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.266 P=0.357 P=0.247 P=0.221 |
|POLY 3 | (e) (e) (e) (e) |P=0.339 P=0.609 P=0.329 P=0.407 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.371 P=0.650 P=0.336 P=0.445 |
|POLY 6 | (e) (e) (e) (e) |P=0.298 P=0.545 P=0.315 P=0.360 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.319 P=0.601 P=0.308 P=0.292 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.419 P=0.691N P=0.339 P=0.500 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 31
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Mesentery: Artery |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/4 (0%) 4/5 (80%) 1/5 (20%) 1/8 (13%) |0/13 (0%) 4/8 (50%) 2/8 (25%) 1/4 (25%) |
|POLY-3 ADJUSTED (b)| 0.0% 80.0% 26.9% 15.2% |0.0% 52.7% 26.3% 28.1% |
|TERMINAL (d) | 0/4 (0%) 1/2 (50%) 1/2 (50%) 0/4 (0%) |0/12 (0%) 0/2 (0%) 2/7 (29%) 1/2 (50%) |
|FIRST INCIDENCE | --- 557 733 (T) 562 |--- 514 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.436N P=0.030 * P=0.362 P=0.487 |P=0.575 P=0.024 * P=0.125 P=0.154 |
|POLY 3 | P=0.224N P=0.006 ** P=0.485 P=0.601 |P=0.365 P=0.002 ** P=0.115 P=0.236 |
|POLY 1.5 | P=0.194N P=0.006 ** P=0.512 P=0.616 |P=0.390 P=0.003 ** P=0.117 P=0.243 |
|POLY 6 | P=0.276N P=0.006 ** P=0.445 P=0.580 |P=0.321 P=0.002 ** P=0.113 P=0.225 |
|LOGISTIC REGRESSION| P=0.147N (e) P=0.362 P=0.992 |P=0.384 P=0.110 P=0.125 P=0.154 |
|COCH-ARM / FISHERS | P=0.211N P=0.040 * P=0.556 P=0.667 |P=0.420 P=0.012 * P=0.133 P=0.235 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/4 (100%) 1/5 (20%) 4/5 (80%) 4/8 (50%) |10/13 (77%) 3/8 (38%) 6/8 (75%) 3/4 (75%) |
|POLY-3 ADJUSTED (b)| 100.0% 26.2% 80.0% 63.1% |79.8% 49.1% 75.0% 75.0% |
|TERMINAL (d) | 4/4 (100%) 1/2 (50%) 1/2 (50%) 3/4 (75%) |10/12 (83%) 2/2 (100%) 5/7 (71%) 1/2 (50%) |
|FIRST INCIDENCE | 733 (T) 733 (T) 562 648 |735 (T) 686 617 645 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.478 P=0.362N P=0.338 P=0.740 |P=0.448 P=0.228 P=0.678N P=0.432 |
|POLY 3 | P=0.457N P=0.019N* P=0.544N P=0.226N |P=0.654 P=0.196N P=0.611N P=0.686N |
|POLY 1.5 | P=0.423N P=0.009N** P=0.544N P=0.167N |P=0.590 P=0.131N P=0.632N P=0.698N |
|POLY 6 | P=0.511N P=0.055N P=0.544N P=0.357N |P=0.623N P=0.348N P=0.581N P=0.666N |
|LOGISTIC REGRESSION| P=0.546N P=0.362N (e) P=0.596N |P=0.506 P=0.722 P=0.687N P=0.709 |
|COCH-ARM / FISHERS | P=0.402N P=0.040N* P=0.556N P=0.141N |P=0.505 P=0.090N P=0.656N P=0.700N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 32
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 5/50 (10%) 4/49 (8%) 5/50 (10%) |7/50 (14%) 7/50 (14%) 7/50 (14%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 6.6% 12.7% 9.5% 12.0% |14.7% 18.8% 15.1% 5.3% |
|TERMINAL (d) | 2/36 (6%) 4/24 (17%) 2/29 (7%) 4/27 (15%) |5/42 (12%) 4/13 (31%) 4/33 (12%) 2/21 (10%) |
|FIRST INCIDENCE | 590 687 669 648 |593 671 672 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.312 P=0.185 P=0.393 P=0.229 |P=0.145N P=0.052 P=0.467 P=0.302N |
|POLY 3 | P=0.358 P=0.278 P=0.454 P=0.308 |P=0.090N P=0.418 P=0.589 P=0.147N |
|POLY 1.5 | P=0.379 P=0.311 P=0.473 P=0.332 |P=0.072N P=0.510 P=0.604 P=0.115N |
|POLY 6 | P=0.329 P=0.248 P=0.433 P=0.280 |P=0.123N P=0.289 P=0.560 P=0.199N |
|LOGISTIC REGRESSION| P=0.368 P=0.278 P=0.506 P=0.328 |P=0.085N P=0.354 P=0.613 P=0.117N |
|COCH-ARM / FISHERS | P=0.404 P=0.369 P=0.500 P=0.369 |P=0.051N P=0.613N P=0.613N P=0.080N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 4/50 (8%) 2/49 (4%) 1/50 (2%) |6/50 (12%) 1/50 (2%) 3/50 (6%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 4.4% 10.2% 4.8% 2.4% |12.8% 2.7% 6.5% 5.2% |
|TERMINAL (d) | 2/36 (6%) 3/24 (13%) 2/29 (7%) 1/27 (4%) |5/42 (12%) 0/13 (0%) 2/33 (6%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) 715 733 (T) 733 (T) |715 657 728 669 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.287N P=0.175 P=0.615 P=0.600N |P=0.405N P=0.379N P=0.369N P=0.410N |
|POLY 3 | P=0.262N P=0.275 P=0.664 P=0.530N |P=0.263N P=0.103N P=0.253N P=0.208N |
|POLY 1.5 | P=0.248N P=0.301 P=0.676 P=0.515N |P=0.261N P=0.078N P=0.245N P=0.175N |
|POLY 6 | P=0.281N P=0.251 P=0.648 P=0.549N |P=0.265N P=0.154N P=0.271N P=0.256N |
|LOGISTIC REGRESSION| P=0.282N P=0.212 P=0.615 P=0.600N |P=0.334N P=0.162N P=0.312N P=0.246N |
|COCH-ARM / FISHERS | P=0.231N P=0.349 P=0.691N P=0.492N |P=0.254N P=0.056N P=0.243N P=0.134N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 33
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Degeneration Hyaline |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 0/49 (0%) 0/50 (0%) |3/50 (6%) 3/50 (6%) 10/50 (20%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% 0.0% 0.0% |6.4% 8.0% 21.8% 5.3% |
|TERMINAL (d) | 0/36 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |3/42 (7%) 0/13 (0%) 9/33 (27%) 2/21 (10%) |
|FIRST INCIDENCE | 561 --- --- --- |735 (T) 671 699 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.475N P=0.531N P=0.513N P=0.513N |P=0.572 P=0.241 P=0.012 * P=0.565 |
|POLY 3 | P=0.447N P=0.530N P=0.519N P=0.520N |P=0.506N P=0.556 P=0.031 * P=0.594N |
|POLY 1.5 | P=0.456N P=0.518N P=0.511N P=0.510N |P=0.452N P=0.607 P=0.034 * P=0.555N |
|POLY 6 | P=0.438N P=0.543N P=0.529N P=0.532N |P=0.578 P=0.478 P=0.027 * P=0.642N |
|LOGISTIC REGRESSION| P=0.466N P=0.289N P=0.251N P=0.282N |P=0.530N P=0.512 P=0.017 * P=0.565 |
|COCH-ARM / FISHERS | P=0.472N P=0.495N P=0.500N P=0.495N |P=0.380N P=0.661N P=0.036 * P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Degeneration Hyaline |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 2/50 (4%) 3/49 (6%) 4/50 (8%) |28/50 (56%) 17/50 (34%) 27/50 (54%) 14/50 (28%) |
|POLY-3 ADJUSTED (b)| 8.8% 5.1% 7.2% 9.4% |58.6% 42.2% 56.9% 34.9% |
|TERMINAL (d) | 3/36 (8%) 2/24 (8%) 2/29 (7%) 1/27 (4%) |25/42 (60%) 5/13 (39%) 21/33 (64%) 6/21 (29%) |
|FIRST INCIDENCE | 561 733 (T) 672 608 |593 533 547 496 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.374 P=0.513N P=0.600N P=0.523 |P=0.250N P=0.063 P=0.232 P=0.452N |
|POLY 3 | P=0.443 P=0.410N P=0.549N P=0.602 |P=0.037N* P=0.088N P=0.516N P=0.019N* |
|POLY 1.5 | P=0.447 P=0.379N P=0.529N P=0.622 |P=0.027N* P=0.045N* P=0.494N P=0.009N** |
|POLY 6 | P=0.436 P=0.443N P=0.573N P=0.579 |P=0.056N P=0.200N P=0.566N P=0.045N* |
|LOGISTIC REGRESSION| P=0.438 P=0.385N P=0.506N P=0.565N |P=0.055N P=0.162N P=0.533N P=0.033N* |
|COCH-ARM / FISHERS | P=0.447 P=0.329N P=0.500N P=0.631N |P=0.017N* P=0.022N* P=0.500N P=0.004N** |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 34
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Ovary |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |2/47 (4%) 2/46 (4%) 0/44 (0%) 1/47 (2%) |
|POLY-3 ADJUSTED (b)| |4.6% 5.6% 0.0% 2.8% |
|TERMINAL (d) | |2/39 (5%) 1/13 (8%) 0/29 (0%) 1/20 (5%) |
|FIRST INCIDENCE | |735 (T) 426 --- 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.479N P=0.391 P=0.306N P=0.726N |
|POLY 3 | |P=0.406N P=0.616 P=0.258N P=0.567N |
|POLY 1.5 | |P=0.396N P=0.651 P=0.254N P=0.539N |
|POLY 6 | |P=0.419N P=0.557 P=0.267N P=0.602N |
|LOGISTIC REGRESSION| |P=0.360N P=0.651N (e) P=0.726N |
|COCH-ARM / FISHERS | |P=0.379N P=0.683 P=0.264N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |12/47 (26%) 9/46 (20%) 11/44 (25%) 9/47 (19%) |
|POLY-3 ADJUSTED (b)| |27.0% 24.6% 26.7% 23.6% |
|TERMINAL (d) | |11/39 (28%) 3/13 (23%) 7/29 (24%) 2/20 (10%) |
|FIRST INCIDENCE | |517 533 589 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.453 P=0.126 P=0.435 P=0.353 |
|POLY 3 | |P=0.443N P=0.505N P=0.586N P=0.462N |
|POLY 1.5 | |P=0.407N P=0.420N P=0.574N P=0.398N |
|POLY 6 | |P=0.486N P=0.570 P=0.583 P=0.542N |
|LOGISTIC REGRESSION| |P=0.393N P=0.440N P=0.573N P=0.360N |
|COCH-ARM / FISHERS | |P=0.348N P=0.330N P=0.573N P=0.311N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 35
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Ovary |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |0/47 (0%) 1/46 (2%) 1/44 (2%) 2/47 (4%) |
|POLY-3 ADJUSTED (b)| |0.0% 2.8% 2.5% 5.4% |
|TERMINAL (d) | |0/39 (0%) 0/13 (0%) 1/29 (3%) 0/20 (0%) |
|FIRST INCIDENCE | |--- 645 735 (T) 608 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.140 P=0.445 P=0.441 P=0.185 |
|POLY 3 | |P=0.164 P=0.456 P=0.482 P=0.201 |
|POLY 1.5 | |P=0.178 P=0.475 P=0.485 P=0.215 |
|POLY 6 | |P=0.147 P=0.427 P=0.474 P=0.184 |
|LOGISTIC REGRESSION| |P=0.232 P=0.531 P=0.441 P=0.288 |
|COCH-ARM / FISHERS | |P=0.198 P=0.495 P=0.484 P=0.247 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Pancreas |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 2/49 (4%) 2/47 (4%) |1/50 (2%) 0/49 (0%) 1/50 (2%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| 6.5% 0.0% 4.8% 4.9% |2.1% 0.0% 2.2% 5.2% |
|TERMINAL (d) | 2/37 (5%) 0/24 (0%) 1/29 (3%) 1/27 (4%) |1/42 (2%) 0/13 (0%) 1/33 (3%) 1/21 (5%) |
|FIRST INCIDENCE | 726 --- 681 715 |735 (T) --- 735 (T) 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.503 P=0.205N P=0.606N P=0.634N |P=0.149 P=0.733N P=0.707 P=0.304 |
|POLY 3 | P=0.565 P=0.151N P=0.544N P=0.560N |P=0.215 P=0.548N P=0.756 P=0.431 |
|POLY 1.5 | P=0.560 P=0.138N P=0.530N P=0.546N |P=0.222 P=0.527N P=0.759 P=0.459 |
|POLY 6 | P=0.563 P=0.165N P=0.562N P=0.579N |P=0.207 P=0.580N P=0.748 P=0.395 |
|LOGISTIC REGRESSION| P=0.524 P=0.180N P=0.571N P=0.608N |P=0.186 (e) P=0.707 P=0.439 |
|COCH-ARM / FISHERS | P=0.543 P=0.121N P=0.510N P=0.530N |P=0.234 P=0.505N P=0.753N P=0.500 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 36
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Pancreas |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/49 (0%) 2/47 (4%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 5.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 2/27 (7%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- --- 733 (T) |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.033 * (e) (e) P=0.172 |(e) (e) (e) (e) |
|POLY 3 | P=0.036 * (e) (e) P=0.208 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.036 * (e) (e) P=0.215 |(e) (e) (e) (e) |
|POLY 6 | P=0.035 * (e) (e) P=0.199 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.172 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.037 * (e) (e) P=0.232 |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 1/47 (2%) 1/45 (2%) 0/50 (0%) |16/50 (32%) 15/50 (30%) 21/48 (44%) 15/49 (31%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.7% 2.6% 0.0% |34.0% 38.6% 47.2% 38.5% |
|TERMINAL (d) | 0/36 (0%) 1/23 (4%) 1/27 (4%) 0/27 (0%) |15/42 (36%) 8/13 (62%) 18/32 (56%) 9/21 (43%) |
|FIRST INCIDENCE | --- 733 (T) 733 (T) --- |678 589 658 487 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.564N P=0.411 P=0.443 (e) |P=0.171 P=0.002 ** P=0.033 * P=0.051 |
|POLY 3 | P=0.555N P=0.464 P=0.469 (e) |P=0.420 P=0.415 P=0.140 P=0.419 |
|POLY 1.5 | P=0.542N P=0.476 P=0.476 (e) |P=0.490 P=0.538 P=0.155 P=0.512 |
|POLY 6 | P=0.571N P=0.452 P=0.460 (e) |P=0.333 P=0.246 P=0.113 P=0.309 |
|LOGISTIC REGRESSION| (e) P=0.411 P=0.443 (e) |P=0.333 P=0.168 P=0.080 P=0.305 |
|COCH-ARM / FISHERS | P=0.524N P=0.495 P=0.484 (e) |P=0.504N P=0.500N P=0.161 P=0.527N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 37
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Pleura: Mesothelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 19/19 (100%) 4/4 (100%) 6/6 (100%) |0/0 (0%) 16/16 (100%) 3/3 (100%) 13/13 (100%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 100.0% 100.0% |0.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 0/0 (0%) 12/12 (100%) 2/2 (100%) 5/5 (100%) |0/0 (0%) 3/3 (100%) 2/2 (100%) 5/5 (100%) |
|FIRST INCIDENCE | --- 504 664 706 |--- 514 681 493 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Preputial Gland |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 21/50 (42%) 19/50 (38%) 20/49 (41%) | |
|POLY-3 ADJUSTED (b)| 53.1% 50.8% 43.2% 48.9% | |
|TERMINAL (d) | 22/37 (60%) 13/24 (54%) 12/29 (41%) 16/27 (59%) | |
|FIRST INCIDENCE | 607 562 562 685 | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.532N P=0.228 P=0.493N P=0.439 | |
|POLY 3 | P=0.407N P=0.499N P=0.227N P=0.426N | |
|POLY 1.5 | P=0.351N P=0.414N P=0.197N P=0.340N | |
|POLY 6 | P=0.498N P=0.574N P=0.265N P=0.543N | |
|LOGISTIC REGRESSION| P=0.424N P=0.559 P=0.295N P=0.585 | |
|COCH-ARM / FISHERS | P=0.300N P=0.274N P=0.157N P=0.237N | |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 38
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 0/50 (0%) 3/50 (6%) 0/49 (0%) | |
|POLY-3 ADJUSTED (b)| 10.8% 0.0% 7.1% 0.0% | |
|TERMINAL (d) | 5/37 (14%) 0/24 (0%) 2/29 (7%) 0/27 (0%) | |
|FIRST INCIDENCE | 733 (T) --- 657 --- | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.104N P=0.082N P=0.488N P=0.066N | |
|POLY 3 | P=0.071N P=0.047N* P=0.403N P=0.043N* | |
|POLY 1.5 | P=0.072N P=0.040N* P=0.384N P=0.038N* | |
|POLY 6 | P=0.072N P=0.055N P=0.427N P=0.049N* | |
|LOGISTIC REGRESSION| P=0.098N (e) P=0.451N (e) | |
|COCH-ARM / FISHERS | P=0.080N P=0.028N* P=0.357N P=0.030N* | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Skin |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 0/50 (0%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 4.3% 2.5% 4.7% 0.0% |0.0% 0.0% 0.0% 2.6% |
|TERMINAL (d) | 2/37 (5%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) 687 682 --- |--- --- --- 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.255N P=0.615N P=0.603 P=0.310N |P=0.177 (e) (e) P=0.428 |
|POLY 3 | P=0.218N P=0.555N P=0.663 P=0.262N |P=0.198 (e) (e) P=0.460 |
|POLY 1.5 | P=0.214N P=0.535N P=0.676 P=0.252N |P=0.204 (e) (e) P=0.477 |
|POLY 6 | P=0.227N P=0.574N P=0.647 P=0.275N |P=0.190 (e) (e) P=0.440 |
|LOGISTIC REGRESSION| P=0.226N P=0.575N P=0.646 (e) |P=0.235 (e) (e) P=0.534 |
|COCH-ARM / FISHERS | P=0.211N P=0.500N P=0.691N P=0.247N |P=0.214 (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 39
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Skin |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 0/50 (0%) |0/50 (0%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 7.0% 0.0% |0.0% 5.4% 0.0% 2.6% |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 1/13 (8%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 687 669 --- |--- 706 --- 650 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.551N P=0.473 P=0.088 (e) |P=0.552 P=0.057 (e) P=0.428 |
|POLY 3 | P=0.536N P=0.468 P=0.105 (e) |P=0.550 P=0.189 (e) P=0.460 |
|POLY 1.5 | P=0.520N P=0.480 P=0.110 (e) |P=0.581 P=0.211 (e) P=0.477 |
|POLY 6 | P=0.559N P=0.457 P=0.099 (e) |P=0.506 P=0.161 (e) P=0.440 |
|LOGISTIC REGRESSION| P=0.504N P=0.497 P=0.120 (e) |P=0.607 P=0.114 (e) P=0.534 |
|COCH-ARM / FISHERS | P=0.500N P=0.500 P=0.121 (e) |P=0.622 P=0.247 (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Skin: Prepuce |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 3/50 (6%) 3/50 (6%) |0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 5.1% 7.0% 7.1% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/37 (3%) 1/24 (4%) 1/29 (3%) 1/27 (4%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) 682 475 619 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.239 P=0.383 P=0.248 P=0.227 |(e) (e) (e) (e) |
|POLY 3 | P=0.263 P=0.445 P=0.280 P=0.272 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.275 P=0.465 P=0.290 P=0.285 |(e) (e) (e) (e) |
|POLY 6 | P=0.248 P=0.426 P=0.265 P=0.257 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.289 P=0.428 P=0.373 P=0.305 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.287 P=0.500 P=0.309 P=0.309 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 40
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Spleen |
| Amyloid Deposition |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/48 (0%) 0/48 (0%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.0% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- 562 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.385N P=0.180 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.412N P=0.205 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.399N P=0.217 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.427N P=0.195 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.374N P=0.279 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.377N P=0.247 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Spleen |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/48 (0%) 0/48 (0%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 4.3% 5.1% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/37 (3%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 662 715 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.147N P=0.554 P=0.289N P=0.301N |(e) (e) (e) (e) |
|POLY 3 | P=0.132N P=0.632 P=0.265N P=0.268N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.129N P=0.655 P=0.258N P=0.259N |(e) (e) (e) (e) |
|POLY 6 | P=0.136N P=0.607 P=0.276N P=0.281N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.133N P=0.635 P=0.240N P=0.242N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.127N P=0.691N P=0.258N P=0.258N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 41
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 34/50 (68%) 23/48 (48%) 29/48 (60%) |16/50 (32%) 36/49 (73%) 26/50 (52%) 21/49 (43%) |
|POLY-3 ADJUSTED (b)| 29.4% 73.7% 50.6% 63.8% |33.0% 79.4% 55.2% 47.8% |
|TERMINAL (d) | 8/37 (22%) 18/24 (75%) 10/29 (35%) 16/27 (59%) |13/42 (31%) 11/13 (85%) 20/33 (61%) 5/21 (24%) |
|FIRST INCIDENCE | 607 405 478 370 |264 426 617 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.046 * P<0.001 ** P=0.019 * P<0.001 ** |P=0.325 P<0.001 ** P=0.006 ** P=0.011 * |
|POLY 3 | P=0.035 * P<0.001 ** P=0.028 * P<0.001 ** |P=0.409N P<0.001 ** P=0.021 * P=0.106 |
|POLY 1.5 | P=0.038 * P<0.001 ** P=0.029 * P<0.001 ** |P=0.358N P<0.001 ** P=0.026 * P=0.129 |
|POLY 6 | P=0.029 * P<0.001 ** P=0.028 * P<0.001 ** |P=0.466N P<0.001 ** P=0.015 * P=0.084 |
|LOGISTIC REGRESSION| P=0.051 P<0.001 ** P=0.058 P=0.002 ** |P=0.200N P<0.001 ** P=0.034 * P=0.326 |
|COCH-ARM / FISHERS | P=0.048 * P<0.001 ** P=0.034 * P<0.001 ** |P=0.269N P<0.001 ** P=0.034 * P=0.182 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Spleen |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 4/48 (8%) 3/48 (6%) |15/50 (30%) 3/49 (6%) 11/50 (22%) 14/49 (29%) |
|POLY-3 ADJUSTED (b)| 0.0% 7.7% 9.8% 7.4% |32.0% 8.1% 23.9% 36.9% |
|TERMINAL (d) | 0/37 (0%) 3/24 (13%) 4/29 (14%) 3/27 (11%) |15/42 (36%) 1/13 (8%) 10/33 (30%) 13/21 (62%) |
|FIRST INCIDENCE | --- 733 (T) 733 (T) 733 (T) |735 (T) 687 672 658 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.206 P=0.056 P=0.036 * P=0.071 |P=0.013 * P=0.276N P=0.501N P=0.026 * |
|POLY 3 | P=0.222 P=0.092 P=0.046 * P=0.097 |P=0.105 P=0.007N** P=0.260N P=0.406 |
|POLY 1.5 | P=0.238 P=0.101 P=0.050 P=0.103 |P=0.119 P=0.004N** P=0.248N P=0.509 |
|POLY 6 | P=0.202 P=0.083 P=0.042 * P=0.089 |P=0.089 P=0.020N* P=0.288N P=0.279 |
|LOGISTIC REGRESSION| (e) P=0.056 P=0.036 * P=0.071 |P=0.030 * P=0.088N P=0.399N P=0.093 |
|COCH-ARM / FISHERS | P=0.257 P=0.121 P=0.054 P=0.114 |P=0.153 P=0.002N** P=0.247N P=0.526N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 42
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/48 (0%) 2/50 (4%) |0/50 (0%) 0/49 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 4.7% |0.0% 0.0% 4.3% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | --- --- --- 562 |--- --- 658 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.043 * (e) (e) P=0.223 |P=0.729 (e) P=0.229 (e) |
|POLY 3 | P=0.042 * (e) (e) P=0.223 |P=0.701 (e) P=0.235 (e) |
|POLY 1.5 | P=0.042 * (e) (e) P=0.231 |P=0.721N (e) P=0.237 (e) |
|POLY 6 | P=0.041 * (e) (e) P=0.215 |P=0.663 (e) P=0.229 (e) |
|LOGISTIC REGRESSION| P=0.043 * (e) (e) P=0.424 |P=0.684N (e) P=0.214 (e) |
|COCH-ARM / FISHERS | P=0.043 * (e) (e) P=0.253 |P=0.695N (e) P=0.247 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/50 (4%) 3/48 (6%) 1/50 (2%) |0/50 (0%) 2/49 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 5.0% 7.1% 2.4% |0.0% 5.4% 0.0% 0.0% |
|TERMINAL (d) | 0/36 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | 664 504 481 668 |--- 580 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.549N P=0.415 P=0.265 P=0.715 |P=0.410N P=0.122 (e) (e) |
|POLY 3 | P=0.538N P=0.455 P=0.280 P=0.741 |P=0.426N P=0.190 (e) (e) |
|POLY 1.5 | P=0.523N P=0.474 P=0.287 P=0.751 |P=0.400N P=0.209 (e) (e) |
|POLY 6 | P=0.559N P=0.435 P=0.272 P=0.729 |P=0.462N P=0.163 (e) (e) |
|LOGISTIC REGRESSION| P=0.483N P=0.639 P=0.507 P=0.726N |P=0.336N P=0.268 (e) (e) |
|COCH-ARM / FISHERS | P=0.504N P=0.508 P=0.301 P=0.747N |P=0.367N P=0.242 (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 43
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 6/50 (12%) 8/48 (17%) 5/50 (10%) |1/50 (2%) 4/49 (8%) 4/50 (8%) 3/50 (6%) |
|POLY-3 ADJUSTED (b)| 4.4% 14.8% 18.2% 11.6% |2.1% 10.4% 8.6% 7.6% |
|TERMINAL (d) | 0/36 (0%) 2/24 (8%) 2/29 (7%) 1/27 (4%) |1/42 (2%) 0/13 (0%) 1/33 (3%) 0/21 (0%) |
|FIRST INCIDENCE | 664 504 475 562 |735 (T) 533 658 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.346 P=0.069 P=0.036 * P=0.155 |P=0.364 P=0.070 P=0.144 P=0.194 |
|POLY 3 | P=0.372 P=0.099 P=0.039 * P=0.194 |P=0.376 P=0.125 P=0.176 P=0.246 |
|POLY 1.5 | P=0.390 P=0.113 P=0.041 * P=0.206 |P=0.416 P=0.147 P=0.180 P=0.270 |
|POLY 6 | P=0.348 P=0.088 P=0.038 * P=0.181 |P=0.323 P=0.096 P=0.169 P=0.217 |
|LOGISTIC REGRESSION| P=0.449 P=0.169 P=0.129 P=0.328 |P=0.583N P=0.256 P=0.176 P=0.412 |
|COCH-ARM / FISHERS | P=0.415 P=0.141 P=0.042 * P=0.226 |P=0.474 P=0.175 P=0.181 P=0.309 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/49 (0%) 2/48 (4%) 2/47 (4%) |2/49 (4%) 0/49 (0%) 1/50 (2%) 1/49 (2%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% 4.8% 5.0% |4.3% 0.0% 2.2% 2.6% |
|TERMINAL (d) | 1/36 (3%) 0/24 (0%) 0/29 (0%) 1/27 (4%) |2/42 (5%) 0/13 (0%) 1/33 (3%) 0/21 (0%) |
|FIRST INCIDENCE | 733 (T) --- 625 727 |735 (T) --- 735 (T) 578 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.229 P=0.581N P=0.454 P=0.402 |P=0.638 P=0.518N P=0.584N P=0.674N |
|POLY 3 | P=0.257 P=0.531N P=0.472 P=0.461 |P=0.611N P=0.292N P=0.503N P=0.566N |
|POLY 1.5 | P=0.257 P=0.520N P=0.480 P=0.472 |P=0.616N P=0.265N P=0.496N P=0.539N |
|POLY 6 | P=0.250 P=0.542N P=0.464 P=0.447 |P=0.604N P=0.338N P=0.517N P=0.600N |
|LOGISTIC REGRESSION| P=0.251 (e) P=0.557 P=0.416 |P=0.638N (e) P=0.584N P=0.494N |
|COCH-ARM / FISHERS | P=0.251 P=0.500N P=0.492 P=0.484 |P=0.619N P=0.247N P=0.492N P=0.500N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 44
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Testes |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 1/50 (2%) 2/50 (4%) 2/50 (4%) | |
|POLY-3 ADJUSTED (b)| 12.8% 2.6% 4.7% 4.8% | |
|TERMINAL (d) | 4/37 (11%) 1/24 (4%) 1/29 (3%) 2/27 (7%) | |
|FIRST INCIDENCE | 615 733 (T) 650 733 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.318N P=0.142N P=0.218N P=0.246N | |
|POLY 3 | P=0.239N P=0.090N P=0.166N P=0.175N | |
|POLY 1.5 | P=0.240N P=0.076N P=0.152N P=0.157N | |
|POLY 6 | P=0.243N P=0.107N P=0.185N P=0.201N | |
|LOGISTIC REGRESSION| P=0.275N P=0.084N P=0.139N P=0.171N | |
|COCH-ARM / FISHERS | P=0.251N P=0.056N P=0.134N P=0.134N | |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) | |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.4% 4.8% | |
|TERMINAL (d) | 0/37 (0%) 0/24 (0%) 0/29 (0%) 2/27 (7%) | |
|FIRST INCIDENCE | --- --- 672 733 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.067 (e) P=0.468 P=0.172 | |
|POLY 3 | P=0.078 (e) P=0.483 P=0.214 | |
|POLY 1.5 | P=0.081 (e) P=0.490 P=0.223 | |
|POLY 6 | P=0.073 (e) P=0.474 P=0.202 | |
|LOGISTIC REGRESSION| P=0.076 (e) P=0.535 P=0.172 | |
|COCH-ARM / FISHERS | P=0.084 (e) P=0.500 P=0.247 | |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 45
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Thymus |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 0/39 (0%) 0/41 (0%) 0/35 (0%) |0/47 (0%) 3/46 (7%) 3/42 (7%) 2/42 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 8.8% 7.7% 6.3% |
|TERMINAL (d) | 0/28 (0%) 0/21 (0%) 0/27 (0%) 0/19 (0%) |0/40 (0%) 2/13 (15%) 3/29 (10%) 2/20 (10%) |
|FIRST INCIDENCE | --- --- --- --- |--- 715 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.303 P=0.010 * P=0.071 P=0.104 |
|POLY 3 | (e) (e) (e) (e) |P=0.297 P=0.077 P=0.095 P=0.168 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.341 P=0.092 P=0.097 P=0.184 |
|POLY 6 | (e) (e) (e) (e) |P=0.245 P=0.059 P=0.091 P=0.152 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.315 P=0.020 * P=0.071 P=0.104 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.416 P=0.117 P=0.101 P=0.220 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Amyloid Deposition |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 2/48 (4%) 0/47 (0%) 0/50 (0%) |0/50 (0%) 0/49 (0%) 0/50 (0%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.3% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 1/23 (4%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/20 (0%) |
|FIRST INCIDENCE | --- 562 --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.384N P=0.175 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.399N P=0.207 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.383N P=0.219 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.417N P=0.196 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.351N P=0.284 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.359N P=0.253 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 46
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/48 (0%) 0/47 (0%) 0/50 (0%) |0/50 (0%) 2/49 (4%) 4/50 (8%) 1/49 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 5.4% 8.7% 2.7% |
|TERMINAL (d) | 0/37 (0%) 0/23 (0%) 0/29 (0%) 0/27 (0%) |0/42 (0%) 1/13 (8%) 4/33 (12%) 1/20 (5%) |
|FIRST INCIDENCE | --- --- --- --- |--- 688 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.467 P=0.068 P=0.037 * P=0.352 |
|POLY 3 | (e) (e) (e) (e) |P=0.497 P=0.188 P=0.058 P=0.453 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.548 P=0.208 P=0.060 P=0.471 |
|POLY 6 | (e) (e) (e) (e) |P=0.427 P=0.160 P=0.053 P=0.431 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.508 P=0.146 P=0.037 * P=0.352 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.615 P=0.242 P=0.059 P=0.495 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/48 (0%) 0/47 (0%) 0/50 (0%) |1/50 (2%) 0/49 (0%) 2/50 (4%) 0/49 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |2.1% 0.0% 4.3% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/23 (0%) 0/29 (0%) 0/27 (0%) |1/42 (2%) 0/13 (0%) 1/33 (3%) 0/20 (0%) |
|FIRST INCIDENCE | --- --- --- --- |735 (T) --- 687 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.546N P=0.733N P=0.433 P=0.648N |
|POLY 3 | (e) (e) (e) (e) |P=0.489N P=0.548N P=0.494 P=0.546N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.477N P=0.527N P=0.499 P=0.529N |
|POLY 6 | (e) (e) (e) (e) |P=0.504N P=0.580N P=0.483 P=0.569N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.515N (e) P=0.496 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.459N P=0.505N P=0.500 P=0.505N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 47
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Tooth |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 2/2 (100%) 1/1 (100%) 0/2 (0%) |0/1 (0%) 0/0 (0%) 2/2 (100%) 0/0 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 100.0% 0.0% |0.0% 0.0% 100.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 2/2 (100%) 1/1 (100%) 0/2 (0%) |0/1 (0%) 0/0 (0%) 1/1 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- 733 (T) 733 (T) --- |--- --- 687 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.098N (e) (e) (e) |P=0.636 (e) P=0.217 (e) |
|POLY 3 | (e) (e) (e) (e) |(e) (e) P=1.000N (e) |
|POLY 1.5 | (e) (e) (e) (e) |(e) (e) P=1.000N (e) |
|POLY 6 | (e) (e) (e) (e) |(e) (e) P=1.000N (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.074N (e) (e) (e) |P=0.807 (e) P=0.333 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Tooth |
| Malformation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/2 (0%) 0/1 (0%) 2/2 (100%) |1/1 (100%) 0/0 (0%) 0/2 (0%) 0/0 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 100.0% |100.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/2 (0%) 0/1 (0%) 2/2 (100%) |1/1 (100%) 0/0 (0%) 0/1 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- 733 (T) |735 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.098 (e) (e) (e) |P=0.841N (e) P=0.500N (e) |
|POLY 3 | (e) (e) (e) (e) |(e) (e) P<0.001N** (e) |
|POLY 1.5 | (e) (e) (e) (e) |(e) (e) P<0.001N** (e) |
|POLY 6 | (e) (e) (e) (e) |(e) (e) P=0.042N* (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.841N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.074 (e) (e) (e) |P=0.807N (e) P=0.333N (e) |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 48
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/48 (0%) 0/47 (0%) |2/48 (4%) 1/49 (2%) 3/49 (6%) 2/48 (4%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.6% 0.0% 0.0% |4.4% 2.7% 6.7% 5.4% |
|TERMINAL (d) | 0/37 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |2/42 (5%) 0/13 (0%) 3/33 (9%) 2/21 (10%) |
|FIRST INCIDENCE | --- 733 (T) --- --- |735 (T) 674 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.602N P=0.414 (e) (e) |P=0.380 P=0.675 P=0.391 P=0.428 |
|POLY 3 | P=0.611N P=0.468 (e) (e) |P=0.477 P=0.575N P=0.492 P=0.617 |
|POLY 1.5 | P=0.602N P=0.480 (e) (e) |P=0.499 P=0.537N P=0.502 P=0.650 |
|POLY 6 | P=0.620N P=0.455 (e) (e) |P=0.445 P=0.631N P=0.473 P=0.573 |
|LOGISTIC REGRESSION| (e) P=0.414 (e) (e) |P=0.431 P=0.636N P=0.391 P=0.428 |
|COCH-ARM / FISHERS | P=0.587N P=0.500 (e) (e) |P=0.533 P=0.492N P=0.510 P=0.692N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Uterus |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |1/50 (2%) 3/49 (6%) 3/50 (6%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| |2.1% 8.1% 6.5% 12.5% |
|TERMINAL (d) | |1/42 (2%) 0/13 (0%) 2/33 (6%) 1/21 (5%) |
|FIRST INCIDENCE | |735 (T) 659 672 510 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.048 * P=0.089 P=0.243 P=0.044 * |
|POLY 3 | |P=0.074 P=0.228 P=0.299 P=0.069 |
|POLY 1.5 | |P=0.085 P=0.260 P=0.305 P=0.081 |
|POLY 6 | |P=0.061 P=0.186 P=0.289 P=0.056 |
|LOGISTIC REGRESSION| |P=0.125 P=0.236 P=0.300 P=0.149 |
|COCH-ARM / FISHERS | |P=0.104 P=0.301 P=0.309 P=0.102 |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 49
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |8/50 (16%) 8/49 (16%) 8/50 (16%) 5/50 (10%) |
|POLY-3 ADJUSTED (b)| |16.8% 21.1% 17.2% 12.6% |
|TERMINAL (d) | |6/42 (14%) 4/13 (31%) 7/33 (21%) 2/21 (10%) |
|FIRST INCIDENCE | |626 589 547 487 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.431N P=0.055 P=0.440 P=0.587 |
|POLY 3 | |P=0.280N P=0.412 P=0.588 P=0.401N |
|POLY 1.5 | |P=0.247N P=0.497 P=0.603 P=0.347N |
|POLY 6 | |P=0.332N P=0.292 P=0.556 P=0.476N |
|LOGISTIC REGRESSION| |P=0.220N P=0.442 P=0.607N P=0.247N |
|COCH-ARM / FISHERS | |P=0.201N P=0.590 P=0.607N P=0.277N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Uterus |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |38/50 (76%) 31/49 (63%) 36/50 (72%) 32/50 (64%) |
|POLY-3 ADJUSTED (b)| |80.6% 71.5% 76.0% 74.1% |
|TERMINAL (d) | |36/42 (86%) 11/13 (85%) 27/33 (82%) 18/21 (86%) |
|FIRST INCIDENCE | |678 426 617 421 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.088 P<0.001 ** P=0.127 P=0.002 ** |
|POLY 3 | |P=0.399N P=0.203N P=0.380N P=0.299N |
|POLY 1.5 | |P=0.338N P=0.146N P=0.373N P=0.217N |
|POLY 6 | |P=0.470N P=0.361N P=0.419N P=0.438N |
|LOGISTIC REGRESSION| |P=0.536 P=0.513N P=0.568 P=0.589 |
|COCH-ARM / FISHERS | |P=0.236N P=0.123N P=0.410N P=0.138N |
|=================================================================================================================================|
Date: 02/22/00 EXPERIMENT: 88124 TEST: 04 Page 50
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - INDIUM PHOSPHIDE
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | CONTROL 0.03 0.1MG/M3 0.3MG/M3 |CONTROL 0.03 0.1MG/M3 0.3MG/M3 |
| | MG/M3 STOP STOP | MG/M3 STOP STOP |
|=================================================================================================================================|
| |
|Uterus |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |0/50 (0%) 0/49 (0%) 1/50 (2%) 2/50 (4%) |
|POLY-3 ADJUSTED (b)| |0.0% 0.0% 2.2% 5.1% |
|TERMINAL (d) | |0/42 (0%) 0/13 (0%) 0/33 (0%) 0/21 (0%) |
|FIRST INCIDENCE | |--- --- 729 510 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.061 (e) P=0.458 P=0.211 |
|POLY 3 | |P=0.072 (e) P=0.496 P=0.200 |
|POLY 1.5 | |P=0.077 (e) P=0.499 P=0.215 |
|POLY 6 | |P=0.067 (e) P=0.489 P=0.182 |
|LOGISTIC REGRESSION| |P=0.142 (e) P=0.482 P=0.345 |
|COCH-ARM / FISHERS | |P=0.085 (e) P=0.500 P=0.247 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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