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TDMS Study 88124-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00       

EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:32:40       

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       

PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7      

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                              FINAL#2,                                                              

                                                                                                                                    


               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      

                                       25019 Moribund Sacrifice                                                                     

                                       25020 Natural Death                                                                          

                                       25021 Terminal Sacrifice                                                                     

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    

LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00      

EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:32:40      

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       

CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124      

PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7     
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      559   561   590   607   615   662   664   669   671   686                 |

 |      686   716   726                                                           |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.03    MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 1    TERMINAL 24        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      331   405   405   421   457   504   530   557   562   562                 |

 |      562   571   574   589   638   682   687   687   687   700                 |

 |      700   706   715   729   730                                               |

 |  CENSORED DEATHS                                                               |

 |      700                                                                       |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      475   478   481   491   562   572   597   625   635   644                 |

 |      650   657   657   664   669   672   678   681   681   682                 |

 |      728                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 733 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 0.3MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      370   471   501   533   562   562   589   589   595   608                 |

 |      619   632   645   648   664   668   671   685   687   706                 |

 |      715   715   727                                                           |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   733 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  94.0  86.0  74.0      |

 |           |                                                                    |

 |           |                                                                    |

 |0.03       |   100.0 100.0 100.0  98.0  92.0  90.0  86.0  72.0  70.0  49.7      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.1MG/M3   |   100.0 100.0 100.0 100.0 100.0  94.0  92.0  86.0  72.0  58.0      |

 |STOP       |                                                                    |

 |           |                                                                    |

 |0.3MG/M3   |   100.0 100.0 100.0 100.0  98.0  96.0  92.0  82.0  70.0  54.0      |

 |STOP       |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.03         0.1MG/M3     0.3MG/M3 |

 |                                             MG/M3        STOP         STOP     |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       74.0%        49.7%        58.0%        54.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.288      P=0.016      P=0.106      P=0.046  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       647.1        587.6        618.0        615.7    |

 |NATURAL DEATHS (C)      |       (15.3)       (23.4)       (17.0)       (18.3)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       710.7        659.7        684.7        679.1    |

 |(STANDARD ERROR)        |       ( 6.6)       (15.5)       (10.7)       (11.8)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 735 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = CONTROL                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 7      CENSORED DEATHS 1    TERMINAL 42        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      264   593   626   664   678   699   715                                   |

 |  CENSORED DEATHS                                                               |

 |      517                                                                       |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.03    MG/M3                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 13        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      426   489   514   514   533   533   533   533   548   580                 |

 |      589   589   617   617   630   645   645   645   645   653                 |

 |      657   659   671   674   674   686   686   687   687   688                 |

 |      688   688   700   706   715   727   732                                   |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                          DOSE = 0.1MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      547   589   617   617   658   664   672   672   681   685                 |

 |      687   687   691   699   699   728   729                                   |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 735 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                          DOSE = 0.3MG/M3 STOP                                  |

 |                       ----------------------------                             |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 1    TERMINAL 21        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      421   421   487   493   496   510   512   533   578   594                 |

 |      600   608   615   619   633   642   645   650   658   669                 |

 |      687   695   695   705   709   726   727   729                             |

 |  CENSORED DEATHS                                                               |

 |      197                                                                       |

 |                                                                                |

 ==================================================================================
                                 INDIUM PHOSPHIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   735 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |CONTROL    |   100.0 100.0  98.0  98.0  98.0  98.0  98.0  96.0  91.9  85.7      |

 |           |                                                                    |

 |           |                                                                    |

 |0.03       |   100.0 100.0 100.0 100.0 100.0  98.0  84.0  76.0  56.0  26.0      |

 |MG/M3      |                                                                    |

 |           |                                                                    |

 |0.1MG/M3   |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  96.0  88.0  66.0      |

 |STOP       |                                                                    |

 |           |                                                                    |

 |0.3MG/M3   |   100.0 100.0 100.0 100.0  95.9  95.9  83.7  77.6  61.2  42.9      |

 |STOP       |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                CONTROL      0.03         0.1MG/M3     0.3MG/M3 |

 |                                             MG/M3        STOP         STOP     |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       85.7%        26.0%        66.0%        42.9%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.029      P<0.001      P=0.044      P<0.001  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       605.6        627.1        666.0        609.2    |

 |NATURAL DEATHS (C)      |       (59.1)       (12.5)       (11.7)       (17.5)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       712.5        655.2        711.5        653.8    |

 |(STANDARD ERROR)        |       (10.8)       (11.4)       ( 6.1)       (16.1)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          INDIUM PHOSPHIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.03    MG/M3    = 2

                                                        0.1MG/M3 STOP    = 3

                                                        0.3MG/M3 STOP    = 4



------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

  100 + 1                                                    2    4                3            1

      |

      |                                                      2    4     2          33           11

      |                                                                            4   4         1    1

   95 +

      |                                                                 2  2        3 34     4        1 1

      |                                                                    2     2    3      4   3      11

      |

   90 +                                                                          2     2         33      1       1

      |

      |                                                                                2    2    43   43

      |                                                                                     2   2      3   3     11

P  85 +

E     |                                                                                         22         33

R     |                                                                                               4 4   33    1 1

C     |

E  80 +                                                                                                 4 4  33

N     |

T     |                                                                                          22       4 4 33    1    1

      |                                                                                                     4 4          11

S  75 +

U     |                                                                                           2   2        3 3        1 1

R     |                                                                                               2      24  33

V     |

I  70 +                                                                                                      2   44 2

V     |

A     |                                                                                                           3322

L     |                                                                                                           433

   65 +

      |                                                                                                             44

      |                                                                                                              224

      |

   60 +                                                                                                             3  4 43

      |

      |                                                                                                               22  3 3

      |                                                                                                                2 24

   55 +

      |                                                                                                                  24 2

      |

      |

   50 +                                                                                                                     2

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 10 obs hidden.
                                                          INDIUM PHOSPHIDE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        CONTROL          = 1

                                                        0.03    MG/M3    = 2

                                                        0.1MG/M3 STOP    = 3

                                                        0.3MG/M3 STOP    = 4



----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

  104 +

      |

      | 1                                         1                        2                   3

      |                                           1                        2         2         3      1

   96 +                                                                    4         2   2            1   31

      |                                                                              44                    1     1

      |                                                                                  2   2            3    3 1 1

      |                                                                               4 4                      3 3 1  1

   88 +                                                                                 44                       33   1  1

      |                                                                                  4   4                           1  1

      |                                                                                      2 2   4              3 3

      |                                                                                        2   2  4

P  80 +                                                                                            2  24            33

E     |                                                                                                44

R     |                                                                                               2 442

C     |                                                                                                  44          33

E  72 +                                                                                                   224

N     |                                                                                                    2442       3   3

T     |                                                                                                      44           3 3

      |                                                                                                                     3

S  64 +                                                                                                       44

U     |                                                                                                       22  4

R     |                                                                                                           4  4

V     |                                                                                                        2 2   44

I  56 +                                                                                                          22

V     |                                                                                                           22  44

A     |                                                                                                                44

L     |                                                                                                            22

   48 +                                                                                                                 4 4

      |                                                                                                             22

      |                                                                                                                   4 4

      |                                                                                                                     4

   40 +

      |

      |                                                                                                              22

      |                                                                                                               22

   32 +                                                                                                                2 2

      |                                                                                                                  22

      |                                                                                                                   2 2

      |                                                                                                                     2

   24 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 12 obs hidden.

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