Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4471

TDMS Study 88124-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/24/00       
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 08:14:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                    FINAL#2, 2 YEAR CHRONIC MICE                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    CONTROL                                                                       
                                       INCLUDE 002    CONTROL                                                                       
                                       INCLUDE 005    0.1MG/M3 STOP                                                                 
                                       INCLUDE 006    0.1MG/M3 STOP                                                                 
                                       INCLUDE 007    0.3MG/M3 STOP                                                                 
                                       INCLUDE 008    0.3MG/M3 STOP                                                                 
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/24/00

EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 08:14:38
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Islets, Pancreatic
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pituitary Gland
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/24/00     
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 08:14:38     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 INDIUM PHOSPHIDE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Intestine Small: Site Unspecified      Carcinoma
                                       Carcinoma or Adenoma
Islets, Pancreatic                     Adenoma
Liver                                  Hepatocellular Adenoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung                                   Alveolar/Bronchiolar Carcinoma
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs                             Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Liver                                  Hepatocellular Adenoma
                                       Hepatocellular Carcinoma
                                       Hepatocellular Carcinoma or Hepatoblastoma
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung                                   Alveolar/Bronchiolar Adenoma
                                       Alveolar/Bronchiolar Carcinoma
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs                             Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/48 (2%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        4.3%             2.4%             0.0%          |  0.0%             0.0%             2.6%            |
|TERMINAL (d)       |        2/37 (5%)        1/29 (3%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          733 (T)          ---           |  ---              ---              658             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.232N         P=0.585N         P=0.310N      |  P=0.228          (e)              P=0.421         |
|POLY 3             |        P=0.189N         P=0.541N         P=0.262N      |  P=0.261          (e)              P=0.460         |
|POLY 1.5           |        P=0.183N         P=0.530N         P=0.252N      |  P=0.275          (e)              P=0.476         |
|POLY 6             |        P=0.197N         P=0.554N         P=0.275N      |  P=0.245          (e)              P=0.439         |
|LOGISTIC REGRESSION|        P=0.232N         P=0.585N         (e)           |  P=0.327          (e)              P=0.527         |
|COCH-ARM / FISHERS |        P=0.175N         P=0.515N         P=0.247N      |  P=0.296          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/48 (2%)        1/49 (2%)     |  2/49 (4%)        2/50 (4%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             2.5%          |  4.3%             4.4%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        1/29 (3%)        1/27 (4%)     |  1/41 (2%)        2/33 (6%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          733 (T)       |  699              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.357          P=0.451          P=0.437       |  P=0.314N         P=0.618          P=0.378N        |
|POLY 3             |        P=0.382          P=0.477          P=0.474       |  P=0.219N         P=0.693          P=0.284N        |
|POLY 1.5           |        P=0.398          P=0.483          P=0.483       |  P=0.199N         P=0.689N         P=0.264N        |
|POLY 6             |        P=0.363          P=0.469          P=0.463       |  P=0.246N         P=0.680          P=0.312N        |
|LOGISTIC REGRESSION|        (e)              P=0.451          P=0.437       |  P=0.246N         P=0.685          P=0.287N        |
|COCH-ARM / FISHERS |        P=0.422          P=0.490          P=0.495       |  P=0.172N         P=0.684N         P=0.247N        |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        2/50 (4%)     |  3/50 (6%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        2.2%             4.7%             4.8%          |  6.4%             4.4%             5.2%            |
|TERMINAL (d)       |        1/37 (3%)        1/29 (3%)        2/27 (7%)     |  3/42 (7%)        2/33 (6%)        1/21 (5%)       |
|FIRST INCIDENCE    |        733 (T)          669              733 (T)       |  735 (T)          735 (T)          512             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.350          P=0.423          P=0.390       |  P=0.535          P=0.609N         P=0.613         |
|POLY 3             |        P=0.405          P=0.471          P=0.462       |  P=0.532N         P=0.510N         P=0.586N        |
|POLY 1.5           |        P=0.424          P=0.483          P=0.478       |  P=0.503N         P=0.502N         P=0.551N        |
|POLY 6             |        P=0.380          P=0.455          P=0.443       |  P=0.567N         P=0.525N         P=0.631N        |
|LOGISTIC REGRESSION|        P=0.390          P=0.468          P=0.390       |  P=0.502N         P=0.609N         P=0.521N        |
|COCH-ARM / FISHERS |        P=0.452          P=0.500          P=0.500       |  P=0.459N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        2/50 (4%)     |  3/50 (6%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        2.2%             7.1%             4.8%          |  6.4%             4.4%             5.2%            |
|TERMINAL (d)       |        1/37 (3%)        2/29 (7%)        2/27 (7%)     |  3/42 (7%)        2/33 (6%)        1/21 (5%)       |
|FIRST INCIDENCE    |        733 (T)          669              733 (T)       |  735 (T)          735 (T)          512             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.386          P=0.230          P=0.390       |  P=0.535          P=0.609N         P=0.613         |
|POLY 3             |        P=0.442          P=0.275          P=0.462       |  P=0.532N         P=0.510N         P=0.586N        |
|POLY 1.5           |        P=0.466          P=0.288          P=0.478       |  P=0.503N         P=0.502N         P=0.551N        |
|POLY 6             |        P=0.412          P=0.261          P=0.443       |  P=0.567N         P=0.525N         P=0.631N        |
|LOGISTIC REGRESSION|        P=0.426          P=0.260          P=0.390       |  P=0.502N         P=0.609N         P=0.521N        |
|COCH-ARM / FISHERS |        P=0.500          P=0.309          P=0.500       |  P=0.459N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Ileum                                                                                                           |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             2.4%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        1/27 (4%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              669              733 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.434          P=0.191          P=0.437       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.447          P=0.220          P=0.478       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.469          P=0.227          P=0.487       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.421          P=0.211          P=0.467       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.495          P=0.262          P=0.437       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.500          P=0.247          P=0.500       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        2/50 (4%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             7.1%             4.8%          |  2.1%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        2/29 (7%)        1/27 (4%)     |  1/42 (2%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              728              608           |  735 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.234          P=0.085          P=0.194       |  P=0.500N         P=0.548N         P=0.638N        |
|POLY 3             |        P=0.265          P=0.103          P=0.216       |  P=0.392N         P=0.504N         P=0.541N        |
|POLY 1.5           |        P=0.284          P=0.110          P=0.224       |  P=0.395N         P=0.501N         P=0.524N        |
|POLY 6             |        P=0.242          P=0.096          P=0.206       |  P=0.386N         P=0.511N         P=0.563N        |
|LOGISTIC REGRESSION|        P=0.283          P=0.081          P=0.264       |  P=0.500N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.313          P=0.121          P=0.247       |  P=0.394N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        5/50 (10%)       3/50 (6%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             11.7%            7.2%          |  2.1%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        2/29 (7%)        2/27 (7%)     |  1/42 (2%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              669              608           |  735 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.167          P=0.019 *        P=0.083       |  P=0.500N         P=0.548N         P=0.638N        |
|POLY 3             |        P=0.192          P=0.024 *        P=0.102       |  P=0.392N         P=0.504N         P=0.541N        |
|POLY 1.5           |        P=0.213          P=0.027 *        P=0.109       |  P=0.395N         P=0.501N         P=0.524N        |
|POLY 6             |        P=0.169          P=0.021 *        P=0.094       |  P=0.386N         P=0.511N         P=0.563N        |
|LOGISTIC REGRESSION|        P=0.223          P=0.026 *        P=0.118       |  P=0.500N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.248          P=0.028 *        P=0.121       |  P=0.394N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        6/50 (12%)       3/50 (6%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.2%             14.1%            7.2%          |  2.1%             0.0%             0.0%            |
|TERMINAL (d)       |        1/37 (3%)        3/29 (10%)       2/27 (7%)     |  1/42 (2%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          669              608           |  735 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.303          P=0.032 *        P=0.218       |  P=0.500N         P=0.548N         P=0.638N        |
|POLY 3             |        P=0.356          P=0.044 *        P=0.271       |  P=0.392N         P=0.504N         P=0.541N        |
|POLY 1.5           |        P=0.386          P=0.049 *        P=0.285       |  P=0.395N         P=0.501N         P=0.524N        |
|POLY 6             |        P=0.322          P=0.038 *        P=0.255       |  P=0.386N         P=0.511N         P=0.563N        |
|LOGISTIC REGRESSION|        P=0.379          P=0.040 *        P=0.284       |  P=0.500N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.431          P=0.056          P=0.309       |  P=0.394N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        0/49 (0%)        0/47 (0%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        6.4%             0.0%             0.0%          |  0.0%             4.3%             0.0%            |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        561              ---              ---           |  ---              699              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.100N         P=0.147N         P=0.156N      |  P=0.709N         P=0.199          (e)             |
|POLY 3             |        P=0.083N         P=0.142N         P=0.148N      |  P=0.649N         P=0.233          (e)             |
|POLY 1.5           |        P=0.083N         P=0.134N         P=0.140N      |  P=0.619N         P=0.237          (e)             |
|POLY 6             |        P=0.085N         P=0.154N         P=0.160N      |  P=0.687N         P=0.226          (e)             |
|LOGISTIC REGRESSION|        P=0.058N         P=0.048N*        P=0.055N      |  P=0.633N         P=0.237          (e)             |
|COCH-ARM / FISHERS |        P=0.086N         P=0.125N         P=0.133N      |  P=0.575N         P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        4.3%             0.0%             4.8%          |  0.0%             0.0%             2.6%            |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        2/27 (7%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        669              ---              733 (T)       |  ---              ---              727             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.463          P=0.287N         P=0.584       |  P=0.203          (e)              P=0.380         |
|POLY 3             |        P=0.531          P=0.259N         P=0.652       |  P=0.260          (e)              P=0.459         |
|POLY 1.5           |        P=0.541          P=0.250N         P=0.670       |  P=0.275          (e)              P=0.476         |
|POLY 6             |        P=0.518          P=0.272N         P=0.630       |  P=0.243          (e)              P=0.437         |
|LOGISTIC REGRESSION|        P=0.506          P=0.238N         P=0.642       |  P=0.225          (e)              P=0.416         |
|COCH-ARM / FISHERS |        P=0.554          P=0.247N         P=0.691N      |  P=0.296          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        17/50 (34%)      23/50 (46%)      32/50 (64%)   |  12/50 (24%)      18/50 (36%)      14/50 (28%)     |
|POLY-3 ADJUSTED (b)|        36.5%            51.8%            70.5%         |  25.6%            37.7%            34.7%           |
|TERMINAL (d)       |        15/37 (41%)      18/29 (62%)      21/27 (78%)   |  12/42 (29%)      10/33 (30%)      6/21 (29%)      |
|FIRST INCIDENCE    |        664              481              370           |  735 (T)          617              496             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.025 *        P<0.001 **    |  P=0.033 *        P=0.053          P=0.028 *       |
|POLY 3             |        P<0.001 **       P=0.099          P<0.001 **    |  P=0.265          P=0.148          P=0.245         |
|POLY 1.5           |        P<0.001 **       P=0.121          P<0.001 **    |  P=0.345          P=0.147          P=0.308         |
|POLY 6             |        P<0.001 **       P=0.074          P<0.001 **    |  P=0.184          P=0.146          P=0.178         |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.076          P<0.001 **    |  P=0.310          P=0.133          P=0.223         |
|COCH-ARM / FISHERS |        P=0.002 **       P=0.154          P=0.002 **    |  P=0.481          P=0.138          P=0.410         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      23/50 (46%)      16/50 (32%)   |  6/50 (12%)       8/50 (16%)       10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        23.2%            47.3%            36.1%         |  12.7%            17.4%            24.7%           |
|TERMINAL (d)       |        5/37 (14%)       6/29 (21%)       7/27 (26%)    |  4/42 (10%)       7/33 (21%)       2/21 (10%)      |
|FIRST INCIDENCE    |        607              478              562           |  626              691              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.153          P=0.007 **       P=0.070       |  P=0.019 *        P=0.238          P=0.038 *       |
|POLY 3             |        P=0.215          P=0.010 *        P=0.130       |  P=0.102          P=0.365          P=0.120         |
|POLY 1.5           |        P=0.252          P=0.009 **       P=0.149       |  P=0.130          P=0.380          P=0.150         |
|POLY 6             |        P=0.179          P=0.012 *        P=0.111       |  P=0.076          P=0.336          P=0.091         |
|LOGISTIC REGRESSION|        P=0.487          P=0.040 *        P=0.208       |  P=0.148          P=0.365          P=0.201         |
|COCH-ARM / FISHERS |        P=0.322          P=0.010 *        P=0.184       |  P=0.186          P=0.387          P=0.207         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/50 (22%)      23/50 (46%)      16/50 (32%)   |  6/50 (12%)       8/50 (16%)       10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        23.2%            47.3%            36.1%         |  12.7%            17.4%            24.7%           |
|TERMINAL (d)       |        5/37 (14%)       6/29 (21%)       7/27 (26%)    |  4/42 (10%)       7/33 (21%)       2/21 (10%)      |
|FIRST INCIDENCE    |        607              478              562           |  626              691              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.153          P=0.007 **       P=0.070       |  P=0.019 *        P=0.238          P=0.038 *       |
|POLY 3             |        P=0.215          P=0.010 *        P=0.130       |  P=0.102          P=0.365          P=0.120         |
|POLY 1.5           |        P=0.252          P=0.009 **       P=0.149       |  P=0.130          P=0.380          P=0.150         |
|POLY 6             |        P=0.179          P=0.012 *        P=0.111       |  P=0.076          P=0.336          P=0.091         |
|LOGISTIC REGRESSION|        P=0.487          P=0.040 *        P=0.208       |  P=0.148          P=0.365          P=0.201         |
|COCH-ARM / FISHERS |        P=0.322          P=0.010 *        P=0.184       |  P=0.186          P=0.387          P=0.207         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        26/50 (52%)      37/50 (74%)      39/50 (78%)   |  18/50 (36%)      24/50 (48%)      23/50 (46%)     |
|POLY-3 ADJUSTED (b)|        54.6%            76.1%            82.7%         |  38.1%            50.1%            54.2%           |
|TERMINAL (d)       |        19/37 (51%)      20/29 (69%)      22/27 (82%)   |  16/42 (38%)      15/33 (46%)      8/21 (38%)      |
|FIRST INCIDENCE    |        607              478              370           |  626              617              496             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.005 **       P<0.001 **    |  P=0.002 **       P=0.046 *        P=0.003 **      |
|POLY 3             |        P=0.003 **       P=0.019 *        P=0.002 **    |  P=0.096          P=0.163          P=0.090         |
|POLY 1.5           |        P=0.004 **       P=0.018 *        P=0.003 **    |  P=0.139          P=0.165          P=0.126         |
|POLY 6             |        P=0.002 **       P=0.021 *        P<0.001 **    |  P=0.063          P=0.156          P=0.061         |
|LOGISTIC REGRESSION|        P=0.007 **       P=0.022 *        P=0.002 **    |  P=0.110          P=0.148          P=0.092         |
|COCH-ARM / FISHERS |        P=0.009 **       P=0.019 *        P=0.006 **    |  P=0.241          P=0.156          P=0.208         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        26/50 (52%)      37/50 (74%)      39/50 (78%)   |  18/50 (36%)      24/50 (48%)      23/50 (46%)     |
|POLY-3 ADJUSTED (b)|        54.6%            76.1%            82.7%         |  38.1%            50.1%            54.2%           |
|TERMINAL (d)       |        19/37 (51%)      20/29 (69%)      22/27 (82%)   |  16/42 (38%)      15/33 (46%)      8/21 (38%)      |
|FIRST INCIDENCE    |        607              478              370           |  626              617              496             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.005 **       P<0.001 **    |  P=0.002 **       P=0.046 *        P=0.003 **      |
|POLY 3             |        P=0.003 **       P=0.019 *        P=0.002 **    |  P=0.096          P=0.163          P=0.090         |
|POLY 1.5           |        P=0.004 **       P=0.018 *        P=0.003 **    |  P=0.139          P=0.165          P=0.126         |
|POLY 6             |        P=0.002 **       P=0.021 *        P<0.001 **    |  P=0.063          P=0.156          P=0.061         |
|LOGISTIC REGRESSION|        P=0.007 **       P=0.022 *        P=0.002 **    |  P=0.110          P=0.148          P=0.092         |
|COCH-ARM / FISHERS |        P=0.009 **       P=0.019 *        P=0.006 **    |  P=0.241          P=0.156          P=0.208         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        13/50 (26%)      7/50 (14%)       13/50 (26%)   |  3/50 (6%)        10/50 (20%)      7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        28.2%            16.3%            30.7%         |  6.4%             21.5%            18.0%           |
|TERMINAL (d)       |        12/37 (32%)      4/29 (14%)       10/27 (37%)   |  2/42 (5%)        6/33 (18%)       4/21 (19%)      |
|FIRST INCIDENCE    |        726              657              562           |  699              658              608             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.189          P=0.252N         P=0.256       |  P=0.036 *        P=0.019 *        P=0.026 *       |
|POLY 3             |        P=0.367          P=0.138N         P=0.490       |  P=0.128          P=0.033 *        P=0.092         |
|POLY 1.5           |        P=0.395          P=0.124N         P=0.530       |  P=0.174          P=0.035 *        P=0.116         |
|POLY 6             |        P=0.333          P=0.155N         P=0.442       |  P=0.083          P=0.029 *        P=0.068         |
|LOGISTIC REGRESSION|        P=0.281          P=0.192N         P=0.373       |  P=0.146          P=0.035 *        P=0.096         |
|COCH-ARM / FISHERS |        P=0.437          P=0.105N         P=0.590N      |  P=0.260          P=0.036 *        P=0.159         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       22/50 (44%)      13/50 (26%)   |  1/50 (2%)        5/50 (10%)       7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        12.9%            48.6%            29.7%         |  2.1%             10.8%            17.6%           |
|TERMINAL (d)       |        4/37 (11%)       14/29 (48%)      6/27 (22%)    |  1/42 (2%)        3/33 (9%)        1/21 (5%)       |
|FIRST INCIDENCE    |        664              478              589           |  735 (T)          664              600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.082          P<0.001 **       P=0.022 *     |  P=0.005 **       P=0.073          P=0.007 **      |
|POLY 3             |        P=0.134          P<0.001 **       P=0.042 *     |  P=0.017 *        P=0.099          P=0.016 *       |
|POLY 1.5           |        P=0.159          P<0.001 **       P=0.049 *     |  P=0.023 *        P=0.102          P=0.021 *       |
|POLY 6             |        P=0.112          P<0.001 **       P=0.036 *     |  P=0.012 *        P=0.093          P=0.012 *       |
|LOGISTIC REGRESSION|        P=0.225          P<0.001 **       P=0.066       |  P=0.036 *        P=0.103          P=0.032 *       |
|COCH-ARM / FISHERS |        P=0.217          P<0.001 **       P=0.062       |  P=0.037 *        P=0.102          P=0.030 *       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        18/50 (36%)      24/50 (48%)      21/50 (42%)   |  4/50 (8%)        15/50 (30%)      14/50 (28%)     |
|POLY-3 ADJUSTED (b)|        38.6%            52.6%            47.1%         |  8.5%             31.9%            34.4%           |
|TERMINAL (d)       |        15/37 (41%)      15/29 (52%)      12/27 (44%)   |  3/42 (7%)        9/33 (27%)       5/21 (24%)      |
|FIRST INCIDENCE    |        664              478              562           |  699              658              600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.114          P=0.036 *        P=0.082       |  P<0.001 **       P=0.002 **       P<0.001 **      |
|POLY 3             |        P=0.312          P=0.122          P=0.270       |  P=0.006 **       P=0.004 **       P=0.002 **      |
|POLY 1.5           |        P=0.340          P=0.135          P=0.294       |  P=0.011 *        P=0.004 **       P=0.004 **      |
|POLY 6             |        P=0.291          P=0.109          P=0.252       |  P=0.003 **       P=0.003 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.321          P=0.110          P=0.232       |  P=0.013 *        P=0.005 **       P=0.005 **      |
|COCH-ARM / FISHERS |        P=0.395          P=0.156          P=0.341       |  P=0.029 *        P=0.005 **       P=0.009 **      |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa Cell Tumor Benign                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  0/47 (0%)        2/44 (5%)        0/47 (0%)       |
|POLY-3 ADJUSTED (b)|                                                        |  0.0%             5.0%             0.0%            |
|TERMINAL (d)       |                                                        |  0/39 (0%)        2/29 (7%)        0/20 (0%)       |
|FIRST INCIDENCE    |                                                        |  ---              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.725N         P=0.176          (e)             |
|POLY 3             |                                                        |  P=0.641N         P=0.217          (e)             |
|POLY 1.5           |                                                        |  P=0.613N         P=0.221          (e)             |
|POLY 6             |                                                        |  P=0.677N         P=0.209          (e)             |
|LOGISTIC REGRESSION|                                                        |  (e)              P=0.176          (e)             |
|COCH-ARM / FISHERS |                                                        |  P=0.572N         P=0.231          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/48 (0%)        0/45 (0%)        0/50 (0%)     |  10/50 (20%)      11/48 (23%)      7/49 (14%)      |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  21.2%            24.8%            18.5%           |
|TERMINAL (d)       |        0/36 (0%)        0/27 (0%)        0/27 (0%)     |  9/42 (21%)       9/32 (28%)       4/21 (19%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  664              687              619             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.335          P=0.264          P=0.364         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.429N         P=0.439          P=0.486N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.350N         P=0.454          P=0.412N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.531N         P=0.408          P=0.580N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.565N         P=0.395          P=0.608N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.243N         P=0.458          P=0.314N        |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/48 (0%)        0/45 (0%)        0/50 (0%)     |  10/50 (20%)      12/48 (25%)      8/49 (16%)      |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  21.2%            27.0%            21.1%           |
|TERMINAL (d)       |        0/36 (0%)        0/27 (0%)        0/27 (0%)     |  9/42 (21%)       9/32 (28%)       4/21 (19%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  664              687              619             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.233          P=0.191          P=0.255         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.532N         P=0.344          P=0.598N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.447N         P=0.359          P=0.523N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.484          P=0.314          P=0.519         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.476          P=0.300          P=0.510         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.324N         P=0.363          P=0.416N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/48 (0%)        2/45 (4%)        1/50 (2%)     |  0/50 (0%)        0/48 (0%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.2%             2.4%          |  0.0%             0.0%             2.7%            |
|TERMINAL (d)       |        0/36 (0%)        1/27 (4%)        1/27 (4%)     |  0/42 (0%)        0/32 (0%)        1/21 (5%)       |
|FIRST INCIDENCE    |        ---              644              733 (T)       |  ---              ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.435          P=0.199          P=0.443       |  P=0.193          (e)              P=0.362         |
|POLY 3             |        P=0.460          P=0.205          P=0.485       |  P=0.259          (e)              P=0.455         |
|POLY 1.5           |        P=0.483          P=0.212          P=0.495       |  P=0.273          (e)              P=0.472         |
|POLY 6             |        P=0.431          P=0.197          P=0.474       |  P=0.242          (e)              P=0.434         |
|LOGISTIC REGRESSION|        P=0.497          P=0.232          P=0.443       |  (e)              (e)              P=0.362         |
|COCH-ARM / FISHERS |        P=0.517          P=0.231          P=0.510       |  P=0.295          (e)              P=0.495         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  2/50 (4%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.4%          |  4.2%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  1/42 (2%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              687           |  664              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.275          (e)              P=0.461       |  P=0.247N         P=0.269N         P=0.368N        |
|POLY 3             |        P=0.278          (e)              P=0.479       |  P=0.177N         P=0.243N         P=0.288N        |
|POLY 1.5           |        P=0.285          (e)              P=0.488       |  P=0.175N         P=0.239N         P=0.266N        |
|POLY 6             |        P=0.269          (e)              P=0.469       |  P=0.178N         P=0.252N         P=0.319N        |
|LOGISTIC REGRESSION|        P=0.297          (e)              P=0.511       |  P=0.167N         P=0.239N         P=0.252N        |
|COCH-ARM / FISHERS |        P=0.296          (e)              P=0.500       |  P=0.171N         P=0.247N         P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/48 (2%)        0/48 (0%)     |  1/50 (2%)        1/50 (2%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        4.3%             2.4%             0.0%          |  2.1%             2.2%             0.0%            |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        669              681              ---           |  664              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.223N         P=0.573N         P=0.302N      |  P=0.472N         P=0.731          P=0.585N        |
|POLY 3             |        P=0.194N         P=0.541N         P=0.268N      |  P=0.396N         P=0.754          P=0.544N        |
|POLY 1.5           |        P=0.189N         P=0.530N         P=0.259N      |  P=0.381N         P=0.759          P=0.527N        |
|POLY 6             |        P=0.201N         P=0.554N         P=0.281N      |  P=0.417N         P=0.746          P=0.566N        |
|LOGISTIC REGRESSION|        P=0.179N         P=0.504N         P=0.247N      |  P=0.360N         P=0.761          P=0.482N        |
|COCH-ARM / FISHERS |        P=0.182N         P=0.515N         P=0.258N      |  P=0.356N         P=0.753N         P=0.505N        |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)     |  1/50 (2%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        4.3%             4.7%             0.0%          |  2.1%             2.2%             0.0%            |
|TERMINAL (d)       |        2/37 (5%)        2/29 (7%)        0/27 (0%)     |  0/42 (0%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          733 (T)          ---           |  678              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.238N         P=0.605          P=0.310N      |  P=0.473N         P=0.726          P=0.588N        |
|POLY 3             |        P=0.194N         P=0.661          P=0.262N      |  P=0.394N         P=0.755          P=0.542N        |
|POLY 1.5           |        P=0.185N         P=0.675          P=0.252N      |  P=0.378N         P=0.759          P=0.525N        |
|POLY 6             |        P=0.207N         P=0.643          P=0.275N      |  P=0.415N         P=0.746          P=0.565N        |
|LOGISTIC REGRESSION|        P=0.238N         P=0.605          (e)           |  P=0.374N         P=0.762          P=0.494N        |
|COCH-ARM / FISHERS |        P=0.172N         P=0.691N         P=0.247N      |  P=0.352N         P=0.753N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.2%             4.7%             0.0%          |  0.0%             2.2%             0.0%            |
|TERMINAL (d)       |        1/37 (3%)        2/29 (7%)        0/27 (0%)     |  0/42 (0%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          733 (T)          ---           |  ---              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.398N         P=0.415          P=0.563N      |  P=0.809          P=0.452          (e)             |
|POLY 3             |        P=0.353N         P=0.469          P=0.522N      |  P=0.740N         P=0.496          (e)             |
|POLY 1.5           |        P=0.339N         P=0.482          P=0.513N      |  P=0.725N         P=0.499          (e)             |
|POLY 6             |        P=0.371N         P=0.452          P=0.533N      |  P=0.757N         P=0.489          (e)             |
|LOGISTIC REGRESSION|        P=0.398N         P=0.415          (e)           |  (e)              P=0.452          (e)             |
|COCH-ARM / FISHERS |        P=0.320N         P=0.500          P=0.500N      |  P=0.704N         P=0.500          (e)             |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)     |                                                    |
|POLY-3 ADJUSTED (b)|        4.3%             2.4%             0.0%          |                                                    |
|TERMINAL (d)       |        2/37 (5%)        1/29 (3%)        0/27 (0%)     |                                                    |
|FIRST INCIDENCE    |        733 (T)          733 (T)          ---           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.232N         P=0.585N         P=0.310N      |                                                    |
|POLY 3             |        P=0.188N         P=0.531N         P=0.262N      |                                                    |
|POLY 1.5           |        P=0.182N         P=0.518N         P=0.252N      |                                                    |
|POLY 6             |        P=0.195N         P=0.548N         P=0.275N      |                                                    |
|LOGISTIC REGRESSION|        P=0.232N         P=0.585N         (e)           |                                                    |
|COCH-ARM / FISHERS |        P=0.175N         P=0.500N         P=0.247N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  0/50 (0%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                                                        |  0.0%             4.4%             5.3%            |
|TERMINAL (d)       |                                                        |  0/42 (0%)        2/33 (6%)        2/21 (10%)      |
|FIRST INCIDENCE    |                                                        |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.092          P=0.187          P=0.104         |
|POLY 3             |                                                        |  P=0.178          P=0.232          P=0.194         |
|POLY 1.5           |                                                        |  P=0.206          P=0.236          P=0.211         |
|POLY 6             |                                                        |  P=0.146          P=0.225          P=0.174         |
|LOGISTIC REGRESSION|                                                        |  (e)              P=0.187          P=0.104         |
|COCH-ARM / FISHERS |                                                        |  P=0.249          P=0.247          P=0.247         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  1/50 (2%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             0.0%          |  2.1%             2.2%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        2/29 (7%)        0/27 (0%)     |  1/42 (2%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  735 (T)          672              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.643N         P=0.186          (e)           |  P=0.473N         P=0.731          P=0.638N        |
|POLY 3             |        P=0.615N         P=0.218          (e)           |  P=0.394N         P=0.757          P=0.541N        |
|POLY 1.5           |        P=0.599N         P=0.226          (e)           |  P=0.377N         P=0.760          P=0.524N        |
|POLY 6             |        P=0.635N         P=0.207          (e)           |  P=0.414N         P=0.750          P=0.563N        |
|LOGISTIC REGRESSION|        (e)              P=0.186          (e)           |  P=0.367N         P=0.762          (e)             |
|COCH-ARM / FISHERS |        P=0.575N         P=0.247          (e)           |  P=0.352N         P=0.753N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        1/50 (2%)        3/50 (6%)     |  3/50 (6%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        6.5%             2.4%             7.2%          |  6.4%             2.2%             2.6%            |
|TERMINAL (d)       |        2/37 (5%)        0/29 (0%)        2/27 (7%)     |  2/42 (5%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        669              681              687           |  664              735 (T)          727             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.431          P=0.388N         P=0.527       |  P=0.476N         P=0.375N         P=0.535N        |
|POLY 3             |        P=0.505          P=0.338N         P=0.611       |  P=0.320N         P=0.315N         P=0.386N        |
|POLY 1.5           |        P=0.520          P=0.325N         P=0.632       |  P=0.301N         P=0.308N         P=0.351N        |
|POLY 6             |        P=0.486          P=0.357N         P=0.584       |  P=0.342N         P=0.329N         P=0.432N        |
|LOGISTIC REGRESSION|        P=0.495          P=0.317N         P=0.601       |  P=0.357N         P=0.307N         P=0.394N        |
|COCH-ARM / FISHERS |        P=0.541          P=0.309N         P=0.661N      |  P=0.272N         P=0.309N         P=0.309N        |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 16
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        3/50 (6%)        3/50 (6%)     |  4/50 (8%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        6.5%             7.1%             7.2%          |  8.5%             4.3%             2.6%            |
|TERMINAL (d)       |        2/37 (5%)        2/29 (7%)        2/27 (7%)     |  3/42 (7%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        669              681              687           |  664              672              727             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.478          P=0.553          P=0.527       |  P=0.338N         P=0.418N         P=0.407N        |
|POLY 3             |        P=0.554          P=0.620          P=0.611       |  P=0.202N         P=0.348N         P=0.251N        |
|POLY 1.5           |        P=0.576          P=0.637          P=0.632       |  P=0.181N         P=0.340N         P=0.219N        |
|POLY 6             |        P=0.525          P=0.597          P=0.584       |  P=0.230N         P=0.363N         P=0.296N        |
|LOGISTIC REGRESSION|        P=0.542          P=0.617          P=0.601       |  P=0.201N         P=0.337N         P=0.270N        |
|COCH-ARM / FISHERS |        P=0.609          P=0.661N         P=0.661N      |  P=0.150N         P=0.339N         P=0.181N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        1/50 (2%)     |  1/50 (2%)        1/50 (2%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.4%          |  2.1%             2.2%             7.7%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  1/42 (2%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              471           |  735 (T)          691              512             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.293          (e)              P=0.496       |  P=0.105          P=0.717          P=0.185         |
|POLY 3             |        P=0.281          (e)              P=0.482       |  P=0.154          P=0.757          P=0.245         |
|POLY 1.5           |        P=0.287          (e)              P=0.489       |  P=0.171          P=0.760          P=0.269         |
|POLY 6             |        P=0.272          (e)              P=0.472       |  P=0.136          P=0.750          P=0.216         |
|LOGISTIC REGRESSION|        P=0.569          (e)              P=0.906       |  P=0.280          P=0.762          P=0.379         |
|COCH-ARM / FISHERS |        P=0.296          (e)              P=0.500       |  P=0.197          P=0.753N         P=0.309         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 17
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        2/50 (4%)     |  8/50 (16%)       10/50 (20%)      13/50 (26%)     |
|POLY-3 ADJUSTED (b)|        2.2%             7.0%             4.7%          |  17.0%            20.9%            33.2%           |
|TERMINAL (d)       |        0/37 (0%)        1/29 (3%)        0/27 (0%)     |  7/42 (17%)       5/33 (15%)       7/21 (33%)      |
|FIRST INCIDENCE    |        686              657              562           |  699              547              600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.431          P=0.232          P=0.457       |  P=0.006 **       P=0.265          P=0.006 **      |
|POLY 3             |        P=0.453          P=0.276          P=0.470       |  P=0.053          P=0.413          P=0.066         |
|POLY 1.5           |        P=0.472          P=0.288          P=0.482       |  P=0.080          P=0.412          P=0.098         |
|POLY 6             |        P=0.430          P=0.262          P=0.454       |  P=0.031 *        P=0.403          P=0.039 *       |
|LOGISTIC REGRESSION|        P=0.598          P=0.320          P=0.711       |  P=0.072          P=0.392          P=0.033 *       |
|COCH-ARM / FISHERS |        P=0.500          P=0.309          P=0.500       |  P=0.141          P=0.398          P=0.163         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        29/50 (58%)      31/50 (62%)      35/50 (70%)   |  25/50 (50%)      36/50 (72%)      26/50 (52%)     |
|POLY-3 ADJUSTED (b)|        61.0%            68.2%            76.4%         |  52.9%            74.9%            61.7%           |
|TERMINAL (d)       |        24/37 (65%)      22/29 (76%)      22/27 (82%)   |  23/42 (55%)      25/33 (76%)      13/21 (62%)     |
|FIRST INCIDENCE    |        561              481              370           |  664              617              496             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.007 **       P=0.076          P=0.007 **    |  P=0.003 **       P<0.001 **       P=0.003 **      |
|POLY 3             |        P=0.065          P=0.300          P=0.074       |  P=0.332          P=0.018 *        P=0.263         |
|POLY 1.5           |        P=0.088          P=0.348          P=0.100       |  P=0.459          P=0.019 *        P=0.353         |
|POLY 6             |        P=0.043 *        P=0.246          P=0.049 *     |  P=0.203          P=0.016 *        P=0.172         |
|LOGISTIC REGRESSION|        P=0.052          P=0.249          P=0.061       |  P=0.222          P=0.012 *        P=0.179         |
|COCH-ARM / FISHERS |        P=0.129          P=0.419          P=0.149       |  P=0.447N         P=0.020 *        P=0.500         |
|=================================================================================================================================|
       Date:  02/24/00                           EXPERIMENT: 88124 TEST: 04                                            Page 18
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        21/50 (42%)      40/50 (80%)      30/50 (60%)   |  20/50 (40%)      25/50 (50%)      27/50 (54%)     |
|POLY-3 ADJUSTED (b)|        43.2%            81.2%            63.0%         |  41.7%            51.2%            62.6%           |
|TERMINAL (d)       |        11/37 (30%)      20/29 (69%)      14/27 (52%)   |  15/42 (36%)      14/33 (42%)      9/21 (43%)      |
|FIRST INCIDENCE    |        561              478              471           |  626              547              512             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.040 *        P<0.001 **       P=0.014 *     |  P<0.001 **       P=0.085          P<0.001 **      |
|POLY 3             |        P=0.100          P<0.001 **       P=0.039 *     |  P=0.033 *        P=0.234          P=0.035 *       |
|POLY 1.5           |        P=0.112          P<0.001 **       P=0.043 *     |  P=0.054          P=0.233          P=0.055         |
|POLY 6             |        P=0.089          P<0.001 **       P=0.035 *     |  P=0.020 *        P=0.224          P=0.021 *       |
|LOGISTIC REGRESSION|        P=0.250          P<0.001 **       P=0.111       |  P=0.069          P=0.211          P=0.045 *       |
|COCH-ARM / FISHERS |        P=0.152          P<0.001 **       P=0.055       |  P=0.119          P=0.211          P=0.115         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #             |  #                #                #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        41/50 (82%)      46/50 (92%)      45/50 (90%)   |  35/50 (70%)      45/50 (90%)      40/50 (80%)     |
|POLY-3 ADJUSTED (b)|        83.7%            93.4%            91.9%         |  73.0%            90.0%            89.0%           |
|TERMINAL (d)       |        30/37 (81%)      26/29 (90%)      24/27 (89%)   |  30/42 (71%)      28/33 (85%)      18/21 (86%)     |
|FIRST INCIDENCE    |        561              478              370           |  626              547              496             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.020 *        P=0.018 *        P=0.013 *     |  P<0.001 **       P=0.002 **       P<0.001 **      |
|POLY 3             |        P=0.181          P=0.112          P=0.170       |  P=0.045 *        P=0.025 *        P=0.038 *       |
|POLY 1.5           |        P=0.191          P=0.109          P=0.178       |  P=0.088          P=0.019 *        P=0.069         |
|POLY 6             |        P=0.171          P=0.125          P=0.164       |  P=0.025 *        P=0.032 *        P=0.023 *       |
|LOGISTIC REGRESSION|        P=0.183          P=0.091          P=0.161       |  P=0.030 *        P=0.012 *        P=0.013 *       |
|COCH-ARM / FISHERS |        P=0.210          P=0.117          P=0.194       |  P=0.256          P=0.011 *        P=0.178         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

--multipart-boundary
Content-type: text/plain
Range: bytes 146643-146643/146643


--multipart-boundary--