National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4426

TDMS Study 88127-06 Pathology Tables

NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02
Route: SKIN APPLICATION                                                                                           Time: 08:37:45

                                                            Final#2




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  3524-68-3

       Lock Date:  06/16/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                      2                         3            3            2            3           
    Moribund Sacrifice                                 1            1                                                   3           
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           14           12           12           13            9           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                                        1 (7%)       1 (7%)       6 (40%)     
      Infiltration Cellular                                                                                3 (20%)      2 (13%)     
      Inflammation, Chronic Active                    12 (80%)     14 (93%)     11 (73%)     14 (93%)     13 (87%)     11 (73%)     
      Necrosis                                                                                                          1 (7%)      
      Pigmentation                                    11 (73%)     11 (73%)      9 (60%)     13 (87%)      5 (33%)      2 (13%)     
      Bile Duct, Hyperplasia                                                                               1 (7%)                   
      Hepatocyte, Necrosis                             2 (13%)      2 (13%)      2 (13%)      3 (20%)      4 (27%)      2 (13%)     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperkeratosis                                   1 (7%)                    3 (20%)      3 (20%)      4 (27%)      4 (27%)     
      Inflammation                                                                                         2 (13%)                  
      Epithelium, Hyperplasia                          1 (7%)                                              2 (13%)                  
      Epithelium, Ulcer                                                                                    1 (7%)                   
   Tooth                                              (4)                       (3)          (3)          (1)                       
      Inflammation, Chronic Active                                                            1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             1 (7%)      
      Inflammation, Chronic Active                                  1 (7%)                                              1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                                                                  1 (7%)      
      Necrosis                                                                                                          1 (7%)      
      Capsule, Hyperplasia                             1 (7%)       4 (27%)      7 (47%)      2 (13%)      1 (7%)       2 (13%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (15)         (15)         (14)         (15)         (15)         (15)         
      Pars Distalis, Cyst                              3 (20%)                   2 (14%)      2 (13%)      4 (27%)      2 (13%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Cyst                                             1 (7%)                                 1 (7%)       2 (13%)                  
   Uterus                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hydrometra                                       1 (7%)                                                           2 (13%)     
      Endometrium, Hyperplasia, Cystic                11 (73%)      9 (60%)      7 (47%)     10 (67%)     11 (73%)      7 (47%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (15)         (14)         (13)         (12)         (15)         (14)         
      Hematopoietic Cell Proliferation                                                                                  2 (14%)     
      Inguinal, Hematopoietic Cell Proliferation                                                                        1 (7%)      
      Inguinal, Hyperplasia                                                                                             1 (7%)      
      Inguinal, Infiltration Cellular                                                                                   1 (7%)      
      Inguinal, Infiltration Cellular, Plasma Cell                                                                      1 (7%)      
      Mediastinal, Hematopoietic Cell Proliferation                                                                     1 (7%)      
      Mediastinal, Hyperplasia                                                                                          1 (7%)      
      Mediastinal, Infiltration Cellular                                                                   3 (20%)      1 (7%)      
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                                                                                            1 (7%)      
      Mediastinal, Necrosis, Lymphoid                                            1 (8%)                                             
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)         (13)         
      Hematopoietic Cell Proliferation                                                                     1 (7%)       8 (62%)     
      Hyperplasia                                      3 (20%)                   1 (7%)       5 (33%)      3 (20%)      1 (8%)      
      Infiltration Cellular                                                                   1 (7%)       2 (13%)      2 (15%)     
      Infiltration Cellular, Plasma Cell                                                                   1 (7%)       1 (8%)      
      Necrosis, Lymphoid                                            1 (7%)       1 (7%)                                             
   Lymph Node, Mesenteric                             (14)         (15)         (15)         (14)         (15)         (15)         
      Infiltration Cellular                                                                                4 (27%)                  
      Necrosis, Lymphoid                                            1 (7%)                                                          
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Depletion Cellular                               2 (13%)      1 (7%)       2 (13%)      1 (7%)       2 (13%)      3 (20%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                                                        2 (13%)     11 (73%)     11 (73%)     
      Infiltration Cellular                                                                                1 (7%)       1 (7%)      
      Necrosis, Lymphoid                                            1 (7%)       1 (7%)                    1 (7%)                   
   Thymus                                             (15)         (15)         (15)         (14)         (14)         (15)         
      Atrophy                                          3 (20%)                   2 (13%)      2 (14%)      3 (21%)      6 (40%)     
      Pigmentation                                                                            1 (7%)                                
      Thymocyte, Necrosis                                           1 (7%)       2 (13%)      2 (14%)                   5 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Epidermis, Skin, Site of Application,                                                                                         
        Hyperplasia                                                              5 (33%)     14 (93%)     14 (93%)     14 (93%)     
      Epidermis, Skin, Site of Application, Ulcer                                                                       1 (7%)      
      Sebaceous Gland, Skin, Site of Application,                                                                                   
         Hyperplasia, Adenomatous                                                                          1 (7%)                   
      Skin, Site of Application, Cyst Epithelial                                                                                    
        Inclusion                                                                                          1 (7%)       1 (7%)      
      Skin, Site of Application, Hyperkeratosis        1 (7%)                    4 (27%)     14 (93%)     11 (73%)     13 (87%)     
      Skin, Site of Application, Inflammation,                                                                                      
         Chronic Active                                                          1 (7%)       9 (60%)     10 (67%)     15 (100%)    
      Subcutaneous Tissue, Hemorrhage                                                         1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             1 (7%)      
      Infiltration Cellular, Mononuclear Cell                                    1 (7%)                                             
      Inflammation, Chronic Active                                                            1 (7%)                    1 (7%)      
      Alveolar Epithelium, Hyperplasia                                                                     1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                     1 (7%)       2 (13%)      1 (7%)       1 (7%)       1 (7%)       1 (7%)      
      Nephropathy                                      3 (20%)                                                          2 (13%)     
      Polyarteritis                                    1 (7%)                                                                       
      Cortex, Cyst                                                                                                      2 (13%)     
      Papilla, Necrosis                                                          1 (7%)                                             
      Renal Tubule, Degeneration                                                                                        1 (7%)      
      Renal Tubule, Hyperplasia                                                  1 (7%)       1 (7%)                                
      Renal Tubule, Necrosis                                                                                            2 (13%)     
      Renal Tubule, Regeneration                       1 (7%)       1 (7%)                    2 (13%)      1 (7%)                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                      3                                                   2            5           
    Moribund Sacrifice                                              1                                      1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           14           15           15           12           10           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                          1 (7%)                                                                       
      Hematopoietic Cell Proliferation                                                                     2 (13%)                  
      Infiltration Cellular                                                                                5 (33%)      3 (20%)     
      Inflammation, Chronic Active                     5 (33%)     11 (73%)     10 (67%)     13 (87%)     13 (87%)      5 (33%)     
      Mineralization                                   1 (7%)                                                                       
      Myelodysplasia                                                                                                    5 (33%)     
      Pigmentation                                                  1 (7%)       1 (7%)                                             
      Hepatocyte, Necrosis                             1 (7%)                    1 (7%)                    1 (7%)       1 (7%)      
      Hepatocyte, Vacuolization Cytoplasmic                                      1 (7%)                                             
   Salivary Glands                                    (1)          (1)                       (1)                       (2)          
      Parotid Gland, Infiltration Cellular                                                                              1 (50%)     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperkeratosis                                   2 (13%)                   1 (7%)                    3 (20%)      4 (27%)     
      Epithelium, Hyperplasia                                                    1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             3 (20%)     
      Inflammation, Chronic Active                                  3 (20%)                                1 (7%)                   
      Myelodysplasia                                                                                                    3 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)         (15)         (15)         
      Hypertrophy                                      7 (47%)     10 (67%)      3 (20%)      5 (33%)      1 (7%)       3 (20%)     
      Myelodysplasia                                                                                                    2 (13%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Medulla                                    (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             2 (13%)     
      Myelodysplasia                                                                                                    2 (13%)     
   Pituitary Gland                                    (15)         (14)         (15)         (15)         (15)         (15)         
      Pars Distalis, Cyst                              1 (7%)                                              3 (20%)                  
   Thyroid Gland                                      (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                                                                         1 (7%)                   
      Myelodysplasia                                                                                                    1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (14)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                5 (33%)      5 (33%)     
      Inflammation, Chronic Active                                  1 (7%)                                              4 (27%)     
      Myelodysplasia                                                                                                    5 (33%)     
      Bilateral, Hypospermia                                                                                            1 (7%)      
      Unilateral, Hypospermia                          1 (7%)       1 (7%)                                              2 (13%)     
   Preputial Gland                                                                                                     (1)          
      Duct, Ectasia                                                                                                     1 (100%)    
   Testes                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Cyst                                             2 (13%)      1 (7%)                    1 (7%)       1 (7%)                   
      Bilateral, Germinal Epithelium, Degeneration                                                         1 (7%)                   
      Unilateral, Germinal Epithelium, Degeneration    1 (7%)       1 (7%)                    2 (13%)      1 (7%)       4 (27%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                                                                                         (1)          
      Myeloid Cell, Hyperplasia                                                                                         1 (100%)    
   Lymph Node                                         (14)         (15)         (14)         (13)         (15)         (14)         
      Hyperplasia                                                                                          1 (7%)                   
      Infiltration Cellular, Plasma Cell                                                                   1 (7%)                   
      Inflammation, Chronic Active                                                                         1 (7%)                   
      Myelodysplasia                                                                                                    1 (7%)      
      Axillary, Hyperplasia, Lymphoid                                                                                   1 (7%)      
      Axillary, Infiltration Cellular                                                                      1 (7%)       1 (7%)      
      Axillary, Infiltration Cellular, Plasma Cell                                                         1 (7%)       1 (7%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Axillary, Infiltration Cellular, Histiocyte                                                                       1 (7%)      
      Inguinal, Myelodysplasia                                                                                          1 (7%)      
      Mediastinal, Hyperplasia                                                                             1 (7%)                   
      Mediastinal, Infiltration Cellular                                                                   4 (27%)      2 (14%)     
      Mediastinal, Myelodysplasia                                                                                       1 (7%)      
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                                                     3 (20%)                  
      Hyperplasia                                                                2 (13%)      1 (7%)       2 (13%)                  
      Hyperplasia, Plasma Cell                                                                                          1 (7%)      
      Infiltration Cellular                                                                                5 (33%)      6 (40%)     
      Infiltration Cellular, Plasma Cell                                                                   1 (7%)       6 (40%)     
      Myelodysplasia                                                                                                    2 (13%)     
      Necrosis, Lymphoid                                                                                   2 (13%)                  
   Lymph Node, Mesenteric                             (12)         (15)         (15)         (15)         (15)         (14)         
      Hematopoietic Cell Proliferation                                                                     1 (7%)       1 (7%)      
      Infiltration Cellular                                                                                4 (27%)      2 (14%)     
      Myelodysplasia                                                                                                    3 (21%)     
      Necrosis, Lymphoid                                                                                   1 (7%)                   
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                          1 (7%)                                                                       
      Depletion Cellular                                                                                   2 (13%)      2 (13%)     
      Hematopoietic Cell Proliferation                 1 (7%)       2 (13%)      1 (7%)       2 (13%)      9 (60%)      8 (53%)     
      Infiltration Cellular                                                                                1 (7%)       4 (27%)     
      Myelodysplasia                                                                                                    4 (27%)     
      Necrosis, Lymphoid                                                                                   2 (13%)      1 (7%)      
   Thymus                                             (15)         (15)         (15)         (15)         (14)         (14)         
      Atrophy                                          4 (27%)      1 (7%)       2 (13%)                   4 (29%)      5 (36%)     
      Myelodysplasia                                                                                                    3 (21%)     
      Thymocyte, Necrosis                                                                                  2 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Dermis, Skin, Site of Application, Necrosis                                                                       1 (7%)      
      Epidermis, Skin, Site of Application,                                                                                         
        Hyperplasia                                                              3 (20%)      8 (53%)     10 (67%)     14 (93%)     
      Epidermis, Skin, Site of Application, Ulcer                                                          1 (7%)                   
      Skin, Site of Application, Cyst Epithelial                                                                                    
        Inclusion                                                                                                       1 (7%)      
      Skin, Site of Application, Hyperkeratosis        1 (7%)                    2 (13%)      6 (40%)     10 (67%)     13 (87%)     
      Skin, Site of Application, Inflammation,                                                                                      
         Chronic Active                                                                       2 (13%)      5 (33%)     12 (80%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                        PENTAERYTHRITOL TRIACRYLATE (PETA)                            Date: 07/12/02    
Route: SKIN APPLICATION                                                                                           Time: 08:37:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                1 (7%)       3 (20%)     
      Inflammation, Chronic Active                                                                         1 (7%)       2 (13%)     
      Myelodysplasia                                                                                                    3 (20%)     
      Alveolar Epithelium, Hyperplasia                                           1 (7%)                                             
      Mediastinum, Infiltration Cellular                                                                                1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hydronephrosis                                                                                                    1 (7%)      
      Infarct                                                                    1 (7%)       2 (13%)                               
      Infiltration Cellular                                                                                2 (13%)      3 (20%)     
      Inflammation, Chronic Active                     1 (7%)                    4 (27%)      4 (27%)      3 (20%)                  
      Mineralization                                                                                       1 (7%)                   
      Myelodysplasia                                                                                                    4 (27%)     
      Nephropathy                                      6 (40%)      1 (7%)                                                          
      Pigmentation                                     1 (7%)                                                                       
      Cortex, Cyst                                                  1 (7%)                    1 (7%)       1 (7%)       1 (7%)      
      Renal Tubule, Dilatation                                                                1 (7%)                                
      Renal Tubule, Regeneration                       1 (7%)       2 (13%)                   3 (20%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.