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TDMS Study 88127-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                             PENTAERYTHRITOL TRIACRYLATE (PETA)                          DATE: 07/12/02       
EXPERIMENT: 88127 TEST: 06                                                                                     TIME: 08:41:06       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                   PAGE:       1        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88127B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 3524-68-3       
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                                                              Final#2                                                               
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                             PENTAERYTHRITOL TRIACRYLATE (PETA)                          DATE: 07/12/02       
EXPERIMENT: 88127 TEST: 06                                                                                     TIME: 08:41:06       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                                        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88127B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 3524-68-3       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF        PENTAERYTHRITOL TRIACRYLATE (PETA)                                                                        
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hypertrophy                                                                                  
                                       Myelodysplasia                                                                               
Adrenal Medulla                        Infiltration Cellular                                                                        
                                       Myelodysplasia                                                                               
Epididymis                             Infiltration Cellular                                                                        
                                       Inflammation Chronic                                                                         
                                       Myelodysplasia                                                                               
Heart                                  Infiltration Cellular                                                                        
                                       Myelodysplasia                                                                               
Kidney                                 Infiltration Cellular                                                                        
                                       Myelodysplasia                                                                               
                                       Nephropathy                                                                                  
Liver                                  Infiltration Cellular                                                                        
                                       Inflammation Chronic                                                                         
                                       Myelodysplasia                                                                               
Lung                                   Infiltration Cellular                                                                        
                                       Inflammation Chronic                                                                         
                                       Myelodysplasia                                                                               
Lymph Node, Mandibular                 Infiltration Cellular                                                                        
                                       Infiltration Cellular Plasma Cell                                                            
                                       Myelodysplasia                                                                               
Lymph Node, Mesenteric                 Infiltration Cellular                                                                        
                                       Myelodysplasia                                                                               
Lymph Node: Mediastinal                Infiltration Cellular                                                                        
Skin: Epidermis, Skin, Site of Application                                                                                          
                                       Hyperplasia                                                                                  
Skin: Skin, Site of Application        Hyperkeratosis                                                                               
                                       Inflammation Chronic                                                                         
Spleen                                 Depletion Cellular                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular                                                                        
                                       Myelodysplasia                                                                               
Stomach, Forestomach                   Hyperkeratosis                                                                               
Testes: Unilateral, Germinal Epithelium                                                                                             
                                       Degeneration                                                                                 
Thymus                                 Atrophy                                                                                      
                                       Myelodysplasia                                                                               
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex: Capsule                Hyperplasia                                                                                  
Kidney: Cortex                         Cyst                                                                                         
Kidney: Renal Tubule                   Necrosis                                                                                     
Liver                                  Hematopoietic Cell Proliferation                                                             
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                             PENTAERYTHRITOL TRIACRYLATE (PETA)                          DATE: 07/12/02       
EXPERIMENT: 88127 TEST: 06                                                                                     TIME: 08:41:06       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                                        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88127B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 3524-68-3       
                                       Infiltration Cellular                                                                        
                                       Pigmentation                                                                                 
Lymph Node                             Hematopoietic Cell Proliferation                                                             
Lymph Node, Mandibular                 Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular                                                                        
Lymph Node: Mediastinal                Infiltration Cellular                                                                        
Skin: Epidermis, Skin, Site of Application                                                                                          
                                       Hyperplasia                                                                                  
Skin: Skin, Site of Application        Hyperkeratosis                                                                               
                                       Inflammation Chronic                                                                         
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Hyperkeratosis                                                                               
Thymus                                 Atrophy                                                                                      
Thymus: Thymocyte                      Necrosis                                                                                     
===============================================================                                                                     
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE 
(PETA)                                                                                                                              
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/15 (47%)       10/15 (67%)      3/15 (20%)       5/15 (33%)       1/15 (7%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        7/13.43          10/14.34         3/15.00          5/15.00          1/14.39          3/13.53         | 
|POLY-3 PERCENT (g) |        52.1%            69.7%            20.0%            33.3%            7.0%             22.2%           | 
|TERMINAL (d)       |        7/12 (58%)       10/14 (71%)      3/15 (20%)       5/15 (33%)       1/12 (8%)        3/10 (30%)      | 
|FIRST INCIDENCE    |        185 (T)          185 (T)          185 (T)          185 (T)          185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.040N*        P=0.389          P=0.053N         P=0.186N         P=0.017N*        P=0.190N        | 
|POLY 3             |        P=0.010N*        P=0.285          P=0.076N         P=0.266N         P=0.007N**       P=0.106N        | 
|POLY 1.5           |        P=0.009N**       P=0.258          P=0.093N         P=0.303N         P=0.009N**       P=0.111N        | 
|POLY 6             |        P=0.011N*        P=0.329          P=0.059N         P=0.224N         P=0.005N**       P=0.106N        | 
|LOGISTIC REGRESSION|        P=0.040N*        P=0.389          P=0.053N         P=0.186N         P=0.017N*        P=0.190N        | 
|COCH-ARM / FISHERS |        P=0.013N*        P=0.231          P=0.123N         P=0.355N         P=0.018N*        P=0.123N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          2/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              (e)              P=0.195         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.228         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.195         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Capsule                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Capsule                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        4/15 (27%)       7/15 (47%)       2/15 (13%)       1/15 (7%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        1/12.95          4/14.05          7/12.72          2/14.77          1/14.94          2/11.35         | 
|POLY-3 PERCENT (g) |        7.7%             28.5%            55.1%            13.5%            6.7%             17.6%           | 
|TERMINAL (d)       |        1/12 (8%)        4/14 (29%)       7/12 (58%)       1/12 (8%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          186 (T)          167              85               134             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.309N         P=0.215          P=0.017 *        P=0.517          P=0.735N         P=0.414         | 
|POLY 3             |        P=0.193N         P=0.187          P=0.008 **       P=0.546          P=0.728N         P=0.452         | 
|POLY 1.5           |        P=0.189N         P=0.181          P=0.009 **       P=0.538          P=0.735N         P=0.470         | 
|POLY 6             |        P=0.200N         P=0.191          P=0.007 **       P=0.547          P=0.725N         P=0.434         | 
|LOGISTIC REGRESSION|        P=0.205N         P=0.215          P=0.017 *        P=0.518          P=0.698          P=0.482         | 
|COCH-ARM / FISHERS |        P=0.191N         P=0.165          P=0.018 *        P=0.500          P=0.759N         P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          2/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              (e)              P=0.195         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.228         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.195         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/13.63          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          2/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              (e)              P=0.195         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.228         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.195         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/13.63          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        5/15 (33%)       5/15 (33%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/13.34          0/15.00          0/15.00          5/14.39          5/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             34.8%            37.0%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/15 (0%)        0/15 (0%)        5/12 (42%)       5/10 (50%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.025 *        P=0.013 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.021 *        P=0.016 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.019 *        P=0.016 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.022 *        P=0.014 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.025 *        P=0.013 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.021 *        P=0.021 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/14 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        4/15 (27%)      | 
|POLY-3 RATE (b)    |        0/13.43          1/13.34          0/15.00          0/15.00          0/14.39          4/14.51         | 
|POLY-3 PERCENT (g) |        0.0%             7.5%             0.0%             0.0%             0.0%             27.6%           | 
|TERMINAL (d)       |        0/12 (0%)        1/13 (8%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              185 (T)          ---              ---              ---              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.516          (e)              (e)              (e)              P=0.065         | 
|POLY 3             |        P<0.001 **       P=0.499          (e)              (e)              (e)              P=0.054         | 
|POLY 1.5           |        P<0.001 **       P=0.493          (e)              (e)              (e)              P=0.050         | 
|POLY 6             |        P<0.001 **       P=0.506          (e)              (e)              (e)              P=0.057         | 
|LOGISTIC REGRESSION|        P=0.003 **       P=0.516          (e)              (e)              (e)              P=0.036 *       | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.483          (e)              (e)              (e)              P=0.050         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        5/15 (33%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/13.34          0/15.00          0/15.00          0/14.39          5/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             37.0%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        5/10 (50%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.013 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.014 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.013 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.021 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis: Unilateral                                                                                                           | 
|     Hypospermia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        1/14 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        1/13.95          1/13.34          0/15.00          0/15.00          0/14.39          2/13.79         | 
|POLY-3 PERCENT (g) |        7.2%             7.5%             0.0%             0.0%             0.0%             14.5%           | 
|TERMINAL (d)       |        0/12 (0%)        1/13 (8%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        145              185 (T)          ---              ---              ---              167             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.182          P=0.751N         P=0.486N         P=0.486N         P=0.486N         P=0.488         | 
|POLY 3             |        P=0.215          P=0.751          P=0.486N         P=0.486N         P=0.494N         P=0.496         | 
|POLY 1.5           |        P=0.220          P=0.748          P=0.491N         P=0.491N         P=0.496N         P=0.498         | 
|POLY 6             |        P=0.209          P=0.755          P=0.479N         P=0.479N         P=0.493N         P=0.490         | 
|LOGISTIC REGRESSION|        P=0.241          P=0.720          P=0.981N         P=0.981N         P=0.928N         P=0.460         | 
|COCH-ARM / FISHERS |        P=0.224          P=0.741          P=0.500N         P=0.500N         P=0.500N         P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis: Unilateral                                                                                                           | 
|     Hypospermia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          3/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             22.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.083         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.105         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.106         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.102         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.083         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          1/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             9.3%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.073          (e)              (e)              (e)              (e)              P=0.443         | 
|POLY 3             |        P=0.090          (e)              (e)              (e)              (e)              P=0.462         | 
|POLY 1.5           |        P=0.095          (e)              (e)              (e)              (e)              P=0.477         | 
|POLY 6             |        P=0.085          (e)              (e)              (e)              (e)              P=0.447         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.443         | 
|COCH-ARM / FISHERS |        P=0.105          (e)              (e)              (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        3/15 (20%)       0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          3/14.34          0/15.00          0/15.00          1/14.41          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             20.9%            0.0%             0.0%             6.9%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        3/14 (21%)       0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              185 (T)          ---              ---              184              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.363N         P=0.143          (e)              (e)              P=0.516          (e)             | 
|POLY 3             |        P=0.295N         P=0.117          (e)              (e)              P=0.514          (e)             | 
|POLY 1.5           |        P=0.294N         P=0.112          (e)              (e)              P=0.509          (e)             | 
|POLY 6             |        P=0.298N         P=0.125          (e)              (e)              P=0.519          (e)             | 
|LOGISTIC REGRESSION|        P=0.332N         P=0.143          (e)              (e)              P=0.520          (e)             | 
|COCH-ARM / FISHERS |        P=0.299N         P=0.112          (e)              (e)              P=0.500          (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/12.95          1/14.05          0/12.72          0/14.49          0/14.03          1/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             7.1%             0.0%             0.0%             0.0%             9.3%            | 
|TERMINAL (d)       |        0/12 (0%)        1/14 (7%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              186 (T)          ---              ---              ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.300          P=0.531          (e)              (e)              (e)              P=0.443         | 
|POLY 3             |        P=0.346          P=0.516          (e)              (e)              (e)              P=0.462         | 
|POLY 1.5           |        P=0.353          P=0.512          (e)              (e)              (e)              P=0.477         | 
|POLY 6             |        P=0.341          P=0.519          (e)              (e)              (e)              P=0.447         | 
|LOGISTIC REGRESSION|        (e)              P=0.531          (e)              (e)              (e)              P=0.443         | 
|COCH-ARM / FISHERS |        P=0.364          P=0.500          (e)              (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          3/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             22.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.083         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.105         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.106         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.102         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.083         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        2/15 (13%)       0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          1/15.00          2/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             6.7%             13.3%            0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        1/15 (7%)        2/15 (13%)       0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              185 (T)          185 (T)          ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.507N         (e)              P=0.545          P=0.286          (e)              (e)             | 
|POLY 3             |        P=0.430N         (e)              P=0.522          P=0.257          (e)              (e)             | 
|POLY 1.5           |        P=0.431N         (e)              P=0.513          P=0.246          (e)              (e)             | 
|POLY 6             |        P=0.433N         (e)              P=0.533          P=0.271          (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.545          P=0.286          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.436N         (e)              P=0.500          P=0.241          (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          2/14.39          3/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             13.9%            22.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        2/12 (17%)       3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.235          P=0.083         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.247          P=0.105         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.241          P=0.106         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.253          P=0.102         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.235          P=0.083         | 
|COCH-ARM / FISHERS |        P=0.002 **       (e)              (e)              (e)              P=0.241          P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        4/15 (27%)       4/15 (27%)       3/15 (20%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        1/13.43          0/14.34          4/15.00          4/15.00          3/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        7.4%             0.0%             26.7%            26.7%            20.9%            0.0%            | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        4/15 (27%)       4/15 (27%)       3/12 (25%)       0/10 (0%)       | 
|FIRST INCIDENCE    |        185 (T)          ---              185 (T)          185 (T)          185 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.417N         P=0.469N         P=0.240          P=0.240          P=0.296          P=0.536N        | 
|POLY 3             |        P=0.297N         P=0.487N         P=0.198          P=0.198          P=0.323          P=0.499N        | 
|POLY 1.5           |        P=0.287N         P=0.493N         P=0.183          P=0.183          P=0.313          P=0.499N        | 
|POLY 6             |        P=0.319N         P=0.479N         P=0.218          P=0.218          P=0.332          P=0.501N        | 
|LOGISTIC REGRESSION|        P=0.417N         (e)              P=0.240          P=0.240          P=0.296          (e)             | 
|COCH-ARM / FISHERS |        P=0.286N         P=0.500N         P=0.165          P=0.165          P=0.299          P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        2/15 (13%)       1/15 (7%)        1/15 (7%)        1/15 (7%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        1/12.95          2/14.05          1/13.51          1/14.49          1/14.03          1/10.72         | 
|POLY-3 PERCENT (g) |        7.7%             14.2%            7.4%             6.9%             7.1%             9.3%            | 
|TERMINAL (d)       |        1/12 (8%)        2/14 (14%)       0/12 (0%)        1/12 (8%)        1/13 (8%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          109              186 (T)          186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.593N         P=0.555          P=0.752N         P=0.765          P=0.747N         P=0.700         | 
|POLY 3             |        P=0.528N         P=0.529          P=0.752N         P=0.736N         P=0.743N         P=0.718         | 
|POLY 1.5           |        P=0.517N         P=0.522          P=0.755N         P=0.739N         P=0.746N         P=0.736         | 
|POLY 6             |        P=0.534N         P=0.533          P=0.753N         P=0.739N         P=0.742N         P=0.699         | 
|LOGISTIC REGRESSION|        P=0.508N         P=0.555          P=0.760N         P=0.765          P=0.747N         P=0.700         | 
|COCH-ARM / FISHERS |        P=0.495N         P=0.500          P=0.759N         P=0.759N         P=0.759N         P=0.759N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        4/15 (27%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          4/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             29.6%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        4/10 (40%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.034 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.043 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.045 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.041 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.034 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.050         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/15 (40%)       1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        6/13.43          1/15.00          0/15.00          0/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        44.7%            6.7%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        6/12 (50%)       0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        185 (T)          129              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.017N*        P=0.032N*        P=0.005N**       P=0.005N**       P=0.011N*        P=0.018N*       | 
|POLY 3             |        P=0.007N**       P=0.020N*        P=0.003N**       P=0.003N**       P=0.003N**       P=0.004N**      | 
|POLY 1.5           |        P=0.006N**       P=0.025N*        P=0.003N**       P=0.003N**       P=0.004N**       P=0.005N**      | 
|POLY 6             |        P=0.008N**       P=0.015N*        P=0.002N**       P=0.002N**       P=0.002N**       P=0.004N**      | 
|LOGISTIC REGRESSION|        P=0.013N*        P=0.045N*        (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.013N*        P=0.040N*        P=0.008N**       P=0.008N**       P=0.008N**       P=0.008N**      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/15 (20%)       0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        3/12.95          0/14.05          0/12.72          0/14.49          0/14.03          2/10.72         | 
|POLY-3 PERCENT (g) |        23.2%            0.0%             0.0%             0.0%             0.0%             18.7%           | 
|TERMINAL (d)       |        3/12 (25%)       0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        186 (T)          ---              ---              ---              ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.331          P=0.089N         P=0.113N         P=0.113N         P=0.100N         P=0.641N        | 
|POLY 3             |        P=0.407          P=0.090N         P=0.107N         P=0.085N         P=0.090N         P=0.591N        | 
|POLY 1.5           |        P=0.409          P=0.094N         P=0.106N         P=0.088N         P=0.093N         P=0.556N        | 
|POLY 6             |        P=0.411          P=0.088N         P=0.110N         P=0.087N         P=0.089N         P=0.628N        | 
|LOGISTIC REGRESSION|        P=0.331          (e)              (e)              (e)              (e)              P=0.641N        | 
|COCH-ARM / FISHERS |        P=0.428          P=0.112N         P=0.112N         P=0.112N         P=0.112N         P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        0/15 (0%)        1/15 (7%)        1/15 (7%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/13.43          1/15.00          0/15.00          1/15.00          1/14.39          1/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             0.0%             6.7%             7.0%             7.4%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        1/15 (7%)        1/12 (8%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              129              ---              185 (T)          185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.279          P=0.500          (e)              P=0.545          P=0.500          P=0.464         | 
|POLY 3             |        P=0.328          P=0.522          (e)              P=0.522          P=0.514          P=0.501         | 
|POLY 1.5           |        P=0.337          P=0.513          (e)              P=0.513          P=0.508          P=0.501         | 
|POLY 6             |        P=0.312          P=0.533          (e)              P=0.533          P=0.519          P=0.499         | 
|LOGISTIC REGRESSION|        P=0.360          (e)              (e)              P=0.545          P=0.500          P=0.464         | 
|COCH-ARM / FISHERS |        P=0.343          P=0.500          (e)              P=0.500          P=0.500          P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          2/11.50         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             17.4%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              113             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.208         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.202         | 
|POLY 1.5           |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.213         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.191         | 
|LOGISTIC REGRESSION|        P=0.018 *        (e)              (e)              (e)              (e)              P=0.248         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          2/11.91         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             16.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.219         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.210         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.218         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.202         | 
|LOGISTIC REGRESSION|        P=0.022 *        (e)              (e)              (e)              (e)              P=0.269         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        2/15 (13%)       0/15 (0%)        3/15 (20%)       0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        1/13.43          2/14.34          0/15.00          3/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        7.4%             14.0%            0.0%             20.0%            0.0%             0.0%            | 
|TERMINAL (d)       |        1/12 (8%)        2/14 (14%)       0/15 (0%)        3/15 (20%)       0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        185 (T)          185 (T)          ---              185 (T)          ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.208N         P=0.555          P=0.455N         P=0.383          P=0.500N         P=0.536N        | 
|POLY 3             |        P=0.159N         P=0.523          P=0.478N         P=0.340          P=0.486N         P=0.499N        | 
|POLY 1.5           |        P=0.156N         P=0.513          P=0.487N         P=0.322          P=0.492N         P=0.499N        | 
|POLY 6             |        P=0.166N         P=0.537          P=0.467N         P=0.362          P=0.481N         P=0.501N        | 
|LOGISTIC REGRESSION|        P=0.208N         P=0.555          (e)              P=0.383          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.158N         P=0.500          P=0.500N         P=0.299          P=0.500N         P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        1/15 (7%)        0/15 (0%)        2/15 (13%)       1/15 (7%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        1/12.95          1/14.05          0/12.72          2/14.49          1/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        7.7%             7.1%             0.0%             13.8%            7.1%             0.0%            | 
|TERMINAL (d)       |        1/12 (8%)        1/14 (7%)        0/12 (0%)        2/12 (17%)       1/13 (8%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          ---              186 (T)          186 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.421N         P=0.730N         P=0.500N         P=0.500          P=0.747N         P=0.557N        | 
|POLY 3             |        P=0.389N         P=0.743N         P=0.504N         P=0.540          P=0.743N         P=0.538N        | 
|POLY 1.5           |        P=0.372N         P=0.747N         P=0.503N         P=0.535          P=0.746N         P=0.523N        | 
|POLY 6             |        P=0.405N         P=0.740N         P=0.507N         P=0.536          P=0.742N         P=0.553N        | 
|LOGISTIC REGRESSION|        P=0.421N         P=0.730N         (e)              P=0.500          P=0.747N         (e)             | 
|COCH-ARM / FISHERS |        P=0.343N         P=0.759N         P=0.500N         P=0.500          P=0.759N         P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          2/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             13.9%            0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        2/12 (17%)       0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.348          (e)              (e)              (e)              P=0.235          (e)             | 
|POLY 3             |        P=0.373          (e)              (e)              (e)              P=0.247          (e)             | 
|POLY 1.5           |        P=0.391          (e)              (e)              (e)              P=0.241          (e)             | 
|POLY 6             |        P=0.343          (e)              (e)              (e)              P=0.253          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.235          (e)             | 
|COCH-ARM / FISHERS |        P=0.414          (e)              (e)              (e)              P=0.241          (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        1/15 (7%)        6/15 (40%)      | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          1/14.59          1/14.03          6/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             6.9%             7.1%             56.0%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        1/13 (8%)        6/9 (67%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              180              186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.516          P=0.516          P=0.003 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.524          P=0.516          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.520          P=0.513          P=0.002 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.522          P=0.517          P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.511          P=0.516          P=0.003 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.500          P=0.500          P=0.008 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        5/15 (33%)       3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          5/14.39          3/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             34.8%            22.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        5/12 (42%)       3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.025 *        P=0.083         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.021 *        P=0.105         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.019 *        P=0.106         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.022 *        P=0.102         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.025 *        P=0.083         | 
|COCH-ARM / FISHERS |        P=0.002 **       (e)              (e)              (e)              P=0.021 *        P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)       2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          3/14.03          2/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             21.4%            18.7%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        3/13 (23%)       2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              P=0.128          P=0.173         | 
|POLY 3             |        P=0.004 **       (e)              (e)              (e)              P=0.120          P=0.188         | 
|POLY 1.5           |        P=0.006 **       (e)              (e)              (e)              P=0.117          P=0.203         | 
|POLY 6             |        P=0.003 **       (e)              (e)              (e)              P=0.121          P=0.172         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.128          P=0.173         | 
|COCH-ARM / FISHERS |        P=0.014 *        (e)              (e)              (e)              P=0.112          P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/15 (33%)       11/15 (73%)      10/15 (67%)      13/15 (87%)      13/15 (87%)      5/15 (33%)      | 
|POLY-3 RATE (b)    |        5/13.43          11/15.00         10/15.00         13/15.00         13/14.67         5/14.19         | 
|POLY-3 PERCENT (g) |        37.2%            73.3%            66.7%            86.7%            88.6%            35.2%           | 
|TERMINAL (d)       |        5/12 (42%)       10/14 (71%)      10/15 (67%)      13/15 (87%)      12/12 (100%)     2/10 (20%)      | 
|FIRST INCIDENCE    |        185 (T)          129              185 (T)          185 (T)          166              160             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.540          P=0.081          P=0.186          P=0.022 *        P=0.003 **       P=0.562         | 
|POLY 3             |        P=0.145N         P=0.051          P=0.111          P=0.004 **       P=0.002 **       P=0.611N        | 
|POLY 1.5           |        P=0.146N         P=0.039 *        P=0.090          P=0.002 **       P=0.002 **       P=0.626N        | 
|POLY 6             |        P=0.150N         P=0.072          P=0.144          P=0.007 **       P=0.003 **       P=0.592N        | 
|LOGISTIC REGRESSION|        P=0.206N         P=0.041 *        P=0.186          P=0.022 *        P=0.007 **       P=0.647N        | 
|COCH-ARM / FISHERS |        P=0.174N         P=0.033 *        P=0.072          P=0.004 **       P=0.004 **       P=0.650N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        12/15 (80%)      14/15 (93%)      11/15 (73%)      14/15 (93%)      13/15 (87%)      11/15 (73%)     | 
|POLY-3 RATE (b)    |        12/12.95         14/14.05         11/12.72         14/14.86         13/14.10         11/11.68        | 
|POLY-3 PERCENT (g) |        92.6%            99.7%            86.5%            94.2%            92.2%            94.1%           | 
|TERMINAL (d)       |        12/12 (100%)     14/14 (100%)     11/12 (92%)      12/12 (100%)     12/13 (92%)      9/9 (100%)      | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          186 (T)          167              182              134             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.069          P=1.000          P=0.500N         P=0.265          P=0.752N         P=0.194         | 
|POLY 3             |        P=0.605N         P=0.524          P=0.560N         P=0.737          P=0.762N         P=0.797         | 
|POLY 1.5           |        P=0.454N         P=0.425          P=0.540N         P=0.629          P=0.726          P=0.729N        | 
|POLY 6             |        P=0.540          P=0.616          P=0.625N         P=0.797          P=0.744N         P=0.735         | 
|LOGISTIC REGRESSION|        P=0.157          P=1.000          P=0.500N         P=0.562          P=0.659N         P=0.390         | 
|COCH-ARM / FISHERS |        P=0.277N         P=0.299          P=0.500N         P=0.299          P=0.500          P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        5/15 (33%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          5/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             37.0%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        5/10 (50%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.013 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.014 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.013 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.021 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          1/14.34          1/15.00          0/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             7.0%             6.7%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        1/14 (7%)        1/15 (7%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              185 (T)          185 (T)          ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.376N         P=0.531          P=0.545          (e)              (e)              (e)             | 
|POLY 3             |        P=0.320N         P=0.513          P=0.522          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.326N         P=0.507          P=0.513          (e)              (e)              (e)             | 
|POLY 6             |        P=0.314N         P=0.521          P=0.533          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.531          P=0.545          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.332N         P=0.500          P=0.500          (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/15 (73%)      11/15 (73%)      9/15 (60%)       13/15 (87%)      5/15 (33%)       2/15 (13%)      | 
|POLY-3 RATE (b)    |        11/12.95         11/14.05         9/12.72          13/14.59         5/14.03          2/11.35         | 
|POLY-3 PERCENT (g) |        84.9%            78.3%            70.8%            89.1%            35.6%            17.6%           | 
|TERMINAL (d)       |        11/12 (92%)      11/14 (79%)      9/12 (75%)       12/12 (100%)     5/13 (39%)       1/9 (11%)       | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          186 (T)          180              186 (T)          134             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.356N         P=0.296N         P=0.249          P=0.011N*        P=0.007N**      | 
|POLY 3             |        P<0.001N**       P=0.521N         P=0.346N         P=0.598          P=0.007N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001N**       P=0.560N         P=0.345N         P=0.547          P=0.009N**       P<0.001N**      | 
|POLY 6             |        P<0.001N**       P=0.494N         P=0.372N         P=0.591          P=0.006N**       P<0.001N**      | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.356N         P=0.296N         P=0.330          P=0.011N*        P=0.003N**      | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.659N         P=0.350N         P=0.326          P=0.033N*        P<0.001N**      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        1/15 (7%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        1/13.43          0/14.34          1/15.00          0/15.00          1/14.39          1/13.53         | 
|POLY-3 PERCENT (g) |        7.4%             0.0%             6.7%             0.0%             7.0%             7.4%            | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        1/15 (7%)        0/15 (0%)        1/12 (8%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        185 (T)          ---              185 (T)          ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.360          P=0.469N         P=0.714N         P=0.455N         P=0.765          P=0.724         | 
|POLY 3             |        P=0.430          P=0.487N         P=0.736N         P=0.478N         P=0.746N         P=0.760N        | 
|POLY 1.5           |        P=0.440          P=0.493N         P=0.746N         P=0.487N         P=0.751N         P=0.760N        | 
|POLY 6             |        P=0.412          P=0.479N         P=0.723N         P=0.467N         P=0.740N         P=0.761         | 
|LOGISTIC REGRESSION|        P=0.360          (e)              P=0.714N         (e)              P=0.765          P=0.724         | 
|COCH-ARM / FISHERS |        P=0.450          P=0.500N         P=0.759N         P=0.500N         P=0.759N         P=0.759N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       2/15 (13%)       2/15 (13%)       3/15 (20%)       4/15 (27%)       2/15 (13%)      | 
|POLY-3 RATE (b)    |        2/12.95          2/14.05          2/12.72          3/14.49          4/14.03          2/11.06         | 
|POLY-3 PERCENT (g) |        15.4%            14.2%            15.7%            20.7%            28.5%            18.1%           | 
|TERMINAL (d)       |        2/12 (17%)       2/14 (14%)       2/12 (17%)       3/12 (25%)       4/13 (31%)       1/9 (11%)       | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          186 (T)          186 (T)          186 (T)          162             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.321          P=0.644N         P=0.704          P=0.500          P=0.364          P=0.592         | 
|POLY 3             |        P=0.358          P=0.670N         P=0.694          P=0.553          P=0.365          P=0.642         | 
|POLY 1.5           |        P=0.401          P=0.676N         P=0.695          P=0.547          P=0.359          P=0.664         | 
|POLY 6             |        P=0.324          P=0.665N         P=0.688          P=0.548          P=0.368          P=0.620         | 
|LOGISTIC REGRESSION|        P=0.355          P=0.644N         P=0.704          P=0.500          P=0.364          P=0.641         | 
|COCH-ARM / FISHERS |        P=0.490          P=0.701N         P=0.701N         P=0.500          P=0.326          P=0.701N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          1/14.39          3/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.0%             22.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        1/12 (8%)        3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.083         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.514          P=0.105         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.508          P=0.106         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.519          P=0.102         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.500          P=0.083         | 
|COCH-ARM / FISHERS |        P=0.002 **       (e)              (e)              (e)              P=0.500          P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          1/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             9.3%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.073          (e)              (e)              (e)              (e)              P=0.443         | 
|POLY 3             |        P=0.090          (e)              (e)              (e)              (e)              P=0.462         | 
|POLY 1.5           |        P=0.095          (e)              (e)              (e)              (e)              P=0.477         | 
|POLY 6             |        P=0.085          (e)              (e)              (e)              (e)              P=0.447         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.443         | 
|COCH-ARM / FISHERS |        P=0.105          (e)              (e)              (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          1/14.39          2/13.57         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.0%             14.7%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        1/12 (8%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          182             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              (e)              P=0.500          P=0.211         | 
|POLY 3             |        P=0.012 *        (e)              (e)              (e)              P=0.514          P=0.232         | 
|POLY 1.5           |        P=0.013 *        (e)              (e)              (e)              P=0.508          P=0.233         | 
|POLY 6             |        P=0.011 *        (e)              (e)              (e)              P=0.519          P=0.230         | 
|LOGISTIC REGRESSION|        P=0.009 **       (e)              (e)              (e)              P=0.500          P=0.223         | 
|COCH-ARM / FISHERS |        P=0.014 *        (e)              (e)              (e)              P=0.500          P=0.241         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          1/14.49          0/14.03          1/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             6.9%             0.0%             9.3%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        1/12 (8%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              186 (T)          ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.172          (e)              (e)              P=0.500          (e)              P=0.443         | 
|POLY 3             |        P=0.195          (e)              (e)              P=0.522          (e)              P=0.462         | 
|POLY 1.5           |        P=0.208          (e)              (e)              P=0.519          (e)              P=0.477         | 
|POLY 6             |        P=0.182          (e)              (e)              P=0.520          (e)              P=0.447         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.500          (e)              P=0.443         | 
|COCH-ARM / FISHERS |        P=0.230          (e)              (e)              P=0.500          (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          3/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             22.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.083         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.105         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.106         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.102         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.083         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/14 (0%)        0/15 (0%)        0/14 (0%)        0/13 (0%)        0/15 (0%)        0/14 (0%)       | 
|POLY-3 RATE (b)    |        0/13.07          0/14.34          0/14.00          0/13.00          0/14.39          0/12.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/14 (0%)        0/13 (0%)        0/12 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/13 (0%)        0/12 (0%)        0/15 (0%)        2/14 (14%)      | 
|POLY-3 RATE (b)    |        0/12.95          0/13.05          0/10.72          0/11.49          0/14.03          2/10.57         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             18.9%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/13 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.173         | 
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.184         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.196         | 
|POLY 6             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.170         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.173         | 
|COCH-ARM / FISHERS |        P=0.012 *        (e)              (e)              (e)              (e)              P=0.224         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          3/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.9%            0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        3/12 (25%)       0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.237          (e)              (e)              (e)              P=0.113          (e)             | 
|POLY 3             |        P=0.263          (e)              (e)              (e)              P=0.118          (e)             | 
|POLY 1.5           |        P=0.282          (e)              (e)              (e)              P=0.113          (e)             | 
|POLY 6             |        P=0.234          (e)              (e)              (e)              P=0.122          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.113          (e)             | 
|COCH-ARM / FISHERS |        P=0.315          (e)              (e)              (e)              P=0.112          (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        8/13 (62%)      | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          1/14.03          8/10.03         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.1%             79.7%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        1/13 (8%)        8/9 (89%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.516          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.516          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.513          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.517          P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.516          P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        2/15 (13%)       1/15 (7%)        2/15 (13%)       1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          2/15.00          1/15.00          2/14.41          1/13.75         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             13.3%            6.7%             13.9%            7.3%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        2/15 (13%)       1/15 (7%)        1/12 (8%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              185 (T)          185 (T)          184              170             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.259          (e)              P=0.286          P=0.545          P=0.249          P=0.500         | 
|POLY 3             |        P=0.344          (e)              P=0.257          P=0.522          P=0.247          P=0.505         | 
|POLY 1.5           |        P=0.349          (e)              P=0.246          P=0.513          P=0.241          P=0.503         | 
|POLY 6             |        P=0.333          (e)              P=0.271          P=0.533          P=0.253          P=0.505         | 
|LOGISTIC REGRESSION|        P=0.340          (e)              P=0.286          P=0.545          P=0.251          P=0.488         | 
|COCH-ARM / FISHERS |        P=0.350          (e)              P=0.241          P=0.500          P=0.241          P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/15 (20%)       0/15 (0%)        1/15 (7%)        5/15 (33%)       3/15 (20%)       1/13 (8%)       | 
|POLY-3 RATE (b)    |        3/13.09          0/14.05          1/12.72          5/15.00          3/14.03          1/10.03         | 
|POLY-3 PERCENT (g) |        22.9%            0.0%             7.9%             33.3%            21.4%            10.0%           | 
|TERMINAL (d)       |        2/12 (17%)       0/14 (0%)        1/12 (8%)        2/12 (17%)       3/13 (23%)       1/9 (11%)       | 
|FIRST INCIDENCE    |        177              ---              186 (T)          167              186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.551          P=0.099N         P=0.310N         P=0.382          P=0.632N         P=0.419N        | 
|POLY 3             |        P=0.529          P=0.092N         P=0.307N         P=0.427          P=0.638N         P=0.400N        | 
|POLY 1.5           |        P=0.562          P=0.095N         P=0.303N         P=0.410          P=0.642N         P=0.383N        | 
|POLY 6             |        P=0.499          P=0.092N         P=0.317N         P=0.431          P=0.640N         P=0.419N        | 
|LOGISTIC REGRESSION|        P=0.591          P=0.099N         P=0.303N         P=0.377          P=0.639N         P=0.400N        | 
|COCH-ARM / FISHERS |        P=0.546N         P=0.112N         P=0.299N         P=0.341          P=0.674N         P=0.356N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        5/15 (33%)       6/15 (40%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          5/14.39          6/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             34.8%            44.4%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        5/12 (42%)       6/10 (60%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.025 *        P=0.005 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.021 *        P=0.005 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.019 *        P=0.005 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.022 *        P=0.004 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.025 *        P=0.005 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.021 *        P=0.008 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        2/15 (13%)       2/13 (15%)      | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          1/14.49          2/14.03          2/10.03         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             6.9%             14.3%            19.9%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        1/12 (8%)        2/13 (15%)       2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              186 (T)          186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012 *        (e)              (e)              P=0.500          P=0.253          P=0.173         | 
|POLY 3             |        P=0.013 *        (e)              (e)              P=0.522          P=0.250          P=0.172         | 
|POLY 1.5           |        P=0.015 *        (e)              (e)              P=0.519          P=0.246          P=0.180         | 
|POLY 6             |        P=0.011 *        (e)              (e)              P=0.520          P=0.251          P=0.165         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.500          P=0.253          P=0.173         | 
|COCH-ARM / FISHERS |        P=0.021 *        (e)              (e)              P=0.500          P=0.241          P=0.206         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        6/15 (40%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          1/14.39          6/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.0%             44.4%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        1/12 (8%)        6/10 (60%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.005 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.514          P=0.005 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.508          P=0.005 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.519          P=0.004 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.500          P=0.005 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.008 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        1/13 (8%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          1/14.03          1/10.03         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.1%             10.0%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        1/13 (8%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.065          (e)              (e)              (e)              P=0.516          P=0.443         | 
|POLY 3             |        P=0.065          (e)              (e)              (e)              P=0.516          P=0.449         | 
|POLY 1.5           |        P=0.070          (e)              (e)              (e)              P=0.513          P=0.456         | 
|POLY 6             |        P=0.060          (e)              (e)              (e)              P=0.517          P=0.441         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.516          P=0.443         | 
|COCH-ARM / FISHERS |        P=0.085          (e)              (e)              (e)              P=0.500          P=0.464         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          2/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              (e)              P=0.195         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.232         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.228         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.195         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/13 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.03         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Necrosis Lymphoid                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          2/14.72          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             13.6%            0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              163              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.382          (e)              (e)              (e)              P=0.273          (e)             | 
|POLY 3             |        P=0.366          (e)              (e)              (e)              P=0.253          (e)             | 
|POLY 1.5           |        P=0.388          (e)              (e)              (e)              P=0.244          (e)             | 
|POLY 6             |        P=0.332          (e)              (e)              (e)              P=0.263          (e)             | 
|LOGISTIC REGRESSION|        P=0.425          (e)              (e)              (e)              P=0.171          (e)             | 
|COCH-ARM / FISHERS |        P=0.414          (e)              (e)              (e)              P=0.241          (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Necrosis Lymphoid                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        0/13 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          1/15.00          1/13.72          0/14.49          0/14.03          0/10.03         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             7.3%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              67               5                ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.334N         P=0.514          P=0.500          (e)              (e)              (e)             | 
|POLY 3             |        P=0.323N         P=0.529          P=0.511          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.330N         P=0.523          P=0.512          (e)              (e)              (e)             | 
|POLY 6             |        P=0.318N         P=0.532          P=0.509          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        P=0.215N         P=0.327          (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.351N         P=0.500          P=0.500          (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/12 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        4/15 (27%)       2/14 (14%)      | 
|POLY-3 RATE (b)    |        0/11.59          0/14.34          0/15.00          0/15.00          4/14.39          2/12.57         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             27.8%            15.9%           | 
|TERMINAL (d)       |        0/11 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        4/12 (33%)       2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              P=0.064          P=0.213         | 
|POLY 3             |        P=0.006 **       (e)              (e)              (e)              P=0.072          P=0.248         | 
|POLY 1.5           |        P=0.007 **       (e)              (e)              (e)              P=0.073          P=0.256         | 
|POLY 6             |        P=0.004 **       (e)              (e)              (e)              P=0.069          P=0.236         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.064          P=0.213         | 
|COCH-ARM / FISHERS |        P=0.012 *        (e)              (e)              (e)              P=0.078          P=0.280         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        4/15 (27%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.09          0/14.05          0/12.72          0/13.63          4/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             28.5%            0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        4/13 (31%)       0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              186 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.170          (e)              (e)              (e)              P=0.064          (e)             | 
|POLY 3             |        P=0.089          (e)              (e)              (e)              P=0.063          (e)             | 
|POLY 1.5           |        P=0.131          (e)              (e)              (e)              P=0.062          (e)             | 
|POLY 6             |        P=0.058          (e)              (e)              (e)              P=0.063          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.064          (e)             | 
|COCH-ARM / FISHERS |        P=0.257          (e)              (e)              (e)              P=0.057          (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/12 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        3/14 (21%)      | 
|POLY-3 RATE (b)    |        0/11.59          0/14.34          0/15.00          0/15.00          0/14.39          3/12.57         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             23.9%           | 
|TERMINAL (d)       |        0/11 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.096         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.116         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.124         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.106         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.096         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.140         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.09          0/14.05          0/12.72          0/13.63          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/14 (0%)        0/15 (0%)        0/14 (0%)        0/13 (0%)        4/15 (27%)       2/14 (14%)      | 
|POLY-3 RATE (b)    |        0/13.07          0/14.34          0/14.00          0/13.00          4/14.39          2/12.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             27.8%            16.0%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/14 (0%)        0/13 (0%)        4/12 (33%)       2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       (e)              (e)              (e)              P=0.054          P=0.173         | 
|POLY 3             |        P=0.006 **       (e)              (e)              (e)              P=0.056          P=0.220         | 
|POLY 1.5           |        P=0.007 **       (e)              (e)              (e)              P=0.055          P=0.225         | 
|POLY 6             |        P=0.004 **       (e)              (e)              (e)              P=0.056          P=0.211         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.054          P=0.173         | 
|COCH-ARM / FISHERS |        P=0.013 *        (e)              (e)              (e)              P=0.057          P=0.241         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/13 (0%)        0/12 (0%)        3/15 (20%)       1/14 (7%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/13.05          0/10.72          0/11.49          3/14.03          1/10.57         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             21.4%            9.5%            | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         3/13 (23%)       1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.050          (e)              (e)              (e)              P=0.128          P=0.443         | 
|POLY 3             |        P=0.039 *        (e)              (e)              (e)              P=0.120          P=0.459         | 
|POLY 1.5           |        P=0.049 *        (e)              (e)              (e)              P=0.117          P=0.470         | 
|POLY 6             |        P=0.030 *        (e)              (e)              (e)              P=0.121          P=0.446         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.128          P=0.443         | 
|COCH-ARM / FISHERS |        P=0.080          (e)              (e)              (e)              P=0.112          P=0.483         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        2/15 (13%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        1/13.92          0/14.05          0/12.72          1/14.77          2/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        7.2%             0.0%             0.0%             6.8%             14.3%            0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        2/13 (15%)       0/9 (0%)        | 
|FIRST INCIDENCE    |        63               ---              ---              167              186 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.614          P=0.500N         P=0.514N         P=0.745N         P=0.519          P=0.514N        | 
|POLY 3             |        P=0.517          P=0.498N         P=0.518N         P=0.747N         P=0.503          P=0.551N        | 
|POLY 1.5           |        P=0.571          P=0.499N         P=0.514N         P=0.749N         P=0.503          P=0.535N        | 
|POLY 6             |        P=0.464          P=0.496N         P=0.522N         P=0.748N         P=0.504          P=0.567N        | 
|LOGISTIC REGRESSION|        P=0.572N         (e)              P=0.389N         P=0.462          P=0.400          P=0.383N        | 
|COCH-ARM / FISHERS |        P=0.622N         P=0.500N         P=0.500N         P=0.759N         P=0.500          P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        1/13.43          0/13.34          0/15.00          0/15.00          3/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        7.4%             0.0%             0.0%             0.0%             20.9%            0.0%            | 
|TERMINAL (d)       |        1/12 (8%)        0/13 (0%)        0/15 (0%)        0/15 (0%)        3/12 (25%)       0/10 (0%)       | 
|FIRST INCIDENCE    |        185 (T)          ---              ---              ---              185 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.446          P=0.484N         P=0.455N         P=0.455N         P=0.296          P=0.536N        | 
|POLY 3             |        P=0.482          P=0.501N         P=0.478N         P=0.478N         P=0.323          P=0.499N        | 
|POLY 1.5           |        P=0.506          P=0.507N         P=0.487N         P=0.487N         P=0.313          P=0.499N        | 
|POLY 6             |        P=0.445          P=0.494N         P=0.467N         P=0.467N         P=0.332          P=0.501N        | 
|LOGISTIC REGRESSION|        P=0.446          (e)              (e)              (e)              P=0.296          (e)             | 
|COCH-ARM / FISHERS |        P=0.531          P=0.517N         P=0.500N         P=0.500N         P=0.299          P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/15 (20%)       0/15 (0%)        2/14 (14%)       2/15 (13%)       4/15 (27%)       2/15 (13%)      | 
|POLY-3 RATE (b)    |        3/12.95          0/14.05          2/12.51          2/14.49          4/14.03          2/10.72         | 
|POLY-3 PERCENT (g) |        23.2%            0.0%             16.0%            13.8%            28.5%            18.7%           | 
|TERMINAL (d)       |        3/12 (25%)       0/14 (0%)        2/12 (17%)       2/12 (17%)       4/13 (31%)       2/9 (22%)       | 
|FIRST INCIDENCE    |        186 (T)          ---              186 (T)          186 (T)          186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.241          P=0.089N         P=0.500N         P=0.500N         P=0.549          P=0.641N        | 
|POLY 3             |        P=0.251          P=0.090N         P=0.517N         P=0.446N         P=0.547          P=0.591N        | 
|POLY 1.5           |        P=0.299          P=0.094N         P=0.523N         P=0.453N         P=0.539          P=0.556N        | 
|POLY 6             |        P=0.210          P=0.088N         P=0.519N         P=0.452N         P=0.551          P=0.628N        | 
|LOGISTIC REGRESSION|        P=0.241          (e)              P=0.500N         P=0.500N         P=0.549          P=0.641N        | 
|COCH-ARM / FISHERS |        P=0.406          P=0.112N         P=0.535N         P=0.500N         P=0.500          P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis, Skin, Site of Application                                                                                       | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        3/15 (20%)       8/15 (53%)       10/15 (67%)      14/15 (93%)     | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          3/15.00          8/15.00          10/14.67         14/15.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             20.0%            53.3%            68.2%            93.3%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        3/15 (20%)       8/15 (53%)       9/12 (75%)       9/10 (90%)      | 
|FIRST INCIDENCE    |        ---              ---              185 (T)          185 (T)          166              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.157          P=0.005 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.127          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.118          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.139          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.157          P=0.005 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.112          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis, Skin, Site of Application                                                                                       | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        5/15 (33%)       14/15 (93%)      14/15 (93%)      14/15 (93%)     | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          5/13.51          14/15.00         14/14.10         14/14.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             37.0%            93.3%            99.3%            100.0%          | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        4/12 (33%)       11/12 (92%)      13/13 (100%)     9/9 (100%)      | 
|FIRST INCIDENCE    |        ---              ---              109              167              182              98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.031 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.018 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.017 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.018 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.025 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.021 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        2/15 (13%)       6/15 (40%)       10/15 (67%)      13/15 (87%)     | 
|POLY-3 RATE (b)    |        1/14.07          0/14.34          2/15.00          6/15.00          10/14.68         13/15.00        | 
|POLY-3 PERCENT (g) |        7.1%             0.0%             13.3%            40.0%            68.1%            86.7%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        2/15 (13%)       6/15 (40%)       8/12 (67%)       8/10 (80%)      | 
|FIRST INCIDENCE    |        132              ---              185 (T)          185 (T)          166              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.514N         P=0.552          P=0.083          P=0.004 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.496N         P=0.523          P=0.043 *        P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.498N         P=0.513          P=0.039 *        P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.492N         P=0.535          P=0.049 *        P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.484N         P=0.218          P=0.015 *        P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.500          P=0.040 *        P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        4/15 (27%)       14/15 (93%)      11/15 (73%)      13/15 (87%)     | 
|POLY-3 RATE (b)    |        1/13.09          0/14.05          4/13.51          14/15.00         11/14.94         13/14.00        | 
|POLY-3 PERCENT (g) |        7.6%             0.0%             29.6%            93.3%            73.6%            92.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        3/12 (25%)       11/12 (92%)      10/13 (77%)      8/9 (89%)       | 
|FIRST INCIDENCE    |        177              ---              109              167              85               98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.485N         P=0.179          P<0.001 **       P=0.002 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.486N         P=0.169          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.489N         P=0.167          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.485N         P=0.165          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.496N         P=0.163          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.165          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       5/15 (33%)       12/15 (80%)     | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          2/15.00          5/14.39          12/14.19        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             13.3%            34.8%            84.6%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        2/15 (13%)       5/12 (42%)       9/10 (90%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              185 (T)          185 (T)          160             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.286          P=0.025 *        P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.257          P=0.021 *        P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.246          P=0.019 *        P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.271          P=0.022 *        P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.286          P=0.025 *        P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.241          P=0.021 *        P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        9/15 (60%)       10/15 (67%)      15/15 (100%)    | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          1/12.72          9/14.77          10/14.03         15/15.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.9%             60.9%            71.3%            100.0%          | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        1/12 (8%)        8/12 (67%)       10/13 (77%)      9/9 (100%)      | 
|FIRST INCIDENCE    |        ---              ---              186 (T)          167              186 (T)          27              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.496          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.497          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.493          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          2/14.98          2/14.01         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             13.4%            14.3%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              163              167             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.013 *        (e)              (e)              (e)              P=0.282          P=0.249         | 
|POLY 3             |        P=0.012 *        (e)              (e)              (e)              P=0.257          P=0.240         | 
|POLY 1.5           |        P=0.013 *        (e)              (e)              (e)              P=0.246          P=0.237         | 
|POLY 6             |        P=0.011 *        (e)              (e)              (e)              P=0.271          P=0.244         | 
|LOGISTIC REGRESSION|        P=0.019 *        (e)              (e)              (e)              P=0.085          P=0.211         | 
|COCH-ARM / FISHERS |        P=0.015 *        (e)              (e)              (e)              P=0.241          P=0.241         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       1/15 (7%)        2/15 (13%)       1/15 (7%)        2/15 (13%)       3/15 (20%)      | 
|POLY-3 RATE (b)    |        2/14.05          1/15.00          2/14.20          1/14.63          2/15.00          3/12.81         | 
|POLY-3 PERCENT (g) |        14.2%            6.7%             14.1%            6.8%             13.3%            23.4%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        63               67               5                177              85               113             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.197          P=0.484N         P=0.678          P=0.483N         P=0.658N         P=0.439         | 
|POLY 3             |        P=0.203          P=0.477N         P=0.695N         P=0.486N         P=0.674N         P=0.456         | 
|POLY 1.5           |        P=0.210          P=0.481N         P=0.693N         P=0.486N         P=0.679N         P=0.466         | 
|POLY 6             |        P=0.197          P=0.476N         P=0.698N         P=0.491N         P=0.673N         P=0.444         | 
|LOGISTIC REGRESSION|        P=0.434          P=0.716N         P=0.744N         P=0.770N         P=0.554          P=0.617         | 
|COCH-ARM / FISHERS |        P=0.238          P=0.500N         P=0.701N         P=0.500N         P=0.701N         P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        2/15 (13%)       1/15 (7%)        2/15 (13%)       9/15 (60%)       8/15 (53%)      | 
|POLY-3 RATE (b)    |        1/13.43          2/15.00          1/15.00          2/15.00          9/14.39          8/13.57         | 
|POLY-3 PERCENT (g) |        7.4%             13.3%            6.7%             13.3%            62.5%            58.9%           | 
|TERMINAL (d)       |        1/12 (8%)        1/14 (7%)        1/15 (7%)        2/15 (13%)       9/12 (75%)       7/10 (70%)      | 
|FIRST INCIDENCE    |        185 (T)          129              185 (T)          185 (T)          185 (T)          182             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.536          P=0.714N         P=0.580          P=0.002 **       P=0.003 **      | 
|POLY 3             |        P<0.001 **       P=0.539          P=0.736N         P=0.539          P<0.001 **       P=0.003 **      | 
|POLY 1.5           |        P<0.001 **       P=0.523          P=0.746N         P=0.523          P<0.001 **       P=0.003 **      | 
|POLY 6             |        P<0.001 **       P=0.558          P=0.723N         P=0.558          P<0.001 **       P=0.002 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.430          P=0.714N         P=0.580          P=0.002 **       P=0.003 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500          P=0.759N         P=0.500          P=0.003 **       P=0.007 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       11/15 (73%)      11/15 (73%)     | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          2/14.49          11/14.03         11/11.91        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             13.8%            78.4%            92.3%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        2/12 (17%)       11/13 (85%)      9/9 (100%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              186 (T)          186 (T)          98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.235          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.258          P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.254          P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.254          P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.235          P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.241          P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        4/15 (27%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          1/14.39          4/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.0%             29.6%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        1/12 (8%)        4/10 (40%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.034 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.514          P=0.043 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.508          P=0.045 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.519          P=0.041 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.500          P=0.034 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.050         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          1/14.03          1/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             7.1%             9.3%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        1/13 (8%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              186 (T)          186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.065          (e)              (e)              (e)              P=0.516          P=0.443         | 
|POLY 3             |        P=0.068          (e)              (e)              (e)              P=0.516          P=0.462         | 
|POLY 1.5           |        P=0.080          (e)              (e)              (e)              P=0.513          P=0.477         | 
|POLY 6             |        P=0.059          (e)              (e)              (e)              P=0.517          P=0.447         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.516          P=0.443         | 
|COCH-ARM / FISHERS |        P=0.104          (e)              (e)              (e)              P=0.500          P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        4/15 (27%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          4/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             29.6%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        4/10 (40%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.034 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.043 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.045 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.041 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.034 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.050         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis Lymphoid                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          2/14.68          1/13.88         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             13.6%            7.2%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              166              160             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.078          (e)              (e)              (e)              P=0.266          P=0.531         | 
|POLY 3             |        P=0.080          (e)              (e)              (e)              P=0.252          P=0.507         | 
|POLY 1.5           |        P=0.084          (e)              (e)              (e)              P=0.243          P=0.504         | 
|POLY 6             |        P=0.074          (e)              (e)              (e)              P=0.262          P=0.508         | 
|LOGISTIC REGRESSION|        P=0.106          (e)              (e)              (e)              P=0.186          P=0.458         | 
|COCH-ARM / FISHERS |        P=0.091          (e)              (e)              (e)              P=0.241          P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis Lymphoid                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        1/15 (7%)        0/15 (0%)        1/15 (7%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          1/15.00          1/13.72          0/14.49          1/14.10          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             7.3%             0.0%             7.1%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              67               5                ---              182              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.501N         P=0.514          P=0.500          (e)              P=0.531          (e)             | 
|POLY 3             |        P=0.512N         P=0.529          P=0.511          (e)              P=0.517          (e)             | 
|POLY 1.5           |        P=0.501N         P=0.523          P=0.512          (e)              P=0.514          (e)             | 
|POLY 6             |        P=0.521N         P=0.532          P=0.509          (e)              P=0.519          (e)             | 
|LOGISTIC REGRESSION|        P=0.375N         P=0.327          (e)              (e)              P=0.512          (e)             | 
|COCH-ARM / FISHERS |        P=0.479N         P=0.500          P=0.500          (e)              P=0.500          (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       0/15 (0%)        1/15 (7%)        0/15 (0%)        3/15 (20%)       4/15 (27%)      | 
|POLY-3 RATE (b)    |        2/14.48          0/14.34          1/15.00          0/15.00          3/15.00          4/14.74         | 
|POLY-3 PERCENT (g) |        13.8%            0.0%             6.7%             0.0%             20.0%            27.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        1/15 (7%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        132              ---              185 (T)          ---              163              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.016 *        P=0.239N         P=0.458N         P=0.224N         P=0.553          P=0.357         | 
|POLY 3             |        P=0.017 *        P=0.233N         P=0.488N         P=0.223N         P=0.517          P=0.335         | 
|POLY 1.5           |        P=0.017 *        P=0.233N         P=0.493N         P=0.227N         P=0.510          P=0.332         | 
|POLY 6             |        P=0.016 *        P=0.233N         P=0.481N         P=0.219N         P=0.525          P=0.337         | 
|LOGISTIC REGRESSION|        P=0.018 *        P=0.268N         P=0.585          P=0.978N         P=0.142          P=0.173         | 
|COCH-ARM / FISHERS |        P=0.018 *        P=0.241N         P=0.500N         P=0.241N         P=0.500          P=0.326         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        3/15 (20%)       3/15 (20%)       4/15 (27%)       4/15 (27%)      | 
|POLY-3 RATE (b)    |        1/13.92          0/14.05          3/15.00          3/15.00          4/15.00          4/13.04         | 
|POLY-3 PERCENT (g) |        7.2%             0.0%             20.0%            20.0%            26.7%            30.7%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        2/13 (15%)       1/9 (11%)       | 
|FIRST INCIDENCE    |        63               ---              5                167              85               98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.033 *        P=0.500N         P=0.309          P=0.335          P=0.212          P=0.164         | 
|POLY 3             |        P=0.034 *        P=0.498N         P=0.326          P=0.326          P=0.187          P=0.139         | 
|POLY 1.5           |        P=0.037 *        P=0.499N         P=0.320          P=0.320          P=0.181          P=0.145         | 
|POLY 6             |        P=0.030 *        P=0.496N         P=0.331          P=0.331          P=0.191          P=0.132         | 
|LOGISTIC REGRESSION|        P=0.108          (e)              P=0.164          P=0.100          P=0.067          P=0.217         | 
|COCH-ARM / FISHERS |        P=0.047 *        P=0.500N         P=0.299          P=0.299          P=0.165          P=0.165         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          2/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             14.3%            0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        2/13 (15%)       0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              186 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.351          (e)              (e)              (e)              P=0.253          (e)             | 
|POLY 3             |        P=0.247          (e)              (e)              (e)              P=0.250          (e)             | 
|POLY 1.5           |        P=0.301          (e)              (e)              (e)              P=0.246          (e)             | 
|POLY 6             |        P=0.198          (e)              (e)              (e)              P=0.251          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.253          (e)             | 
|COCH-ARM / FISHERS |        P=0.414          (e)              (e)              (e)              P=0.241          (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          1/15.00          0/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             6.7%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        1/15 (7%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              185 (T)          ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.608N         (e)              P=0.545          (e)              (e)              (e)             | 
|POLY 3             |        P=0.541N         (e)              P=0.522          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.549N         (e)              P=0.513          (e)              (e)              (e)             | 
|POLY 6             |        P=0.531N         (e)              P=0.533          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.545          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.561N         (e)              P=0.500          (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        1/12.95          0/14.05          0/12.72          0/14.49          2/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        7.7%             0.0%             0.0%             0.0%             14.3%            0.0%            | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        2/13 (15%)       0/9 (0%)        | 
|FIRST INCIDENCE    |        186 (T)          ---              ---              ---              186 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.588          P=0.469N         P=0.500N         P=0.500N         P=0.529          P=0.557N        | 
|POLY 3             |        P=0.498          P=0.484N         P=0.504N         P=0.478N         P=0.528          P=0.538N        | 
|POLY 1.5           |        P=0.550          P=0.488N         P=0.503N         P=0.480N         P=0.524          P=0.523N        | 
|POLY 6             |        P=0.446          P=0.481N         P=0.507N         P=0.480N         P=0.530          P=0.553N        | 
|LOGISTIC REGRESSION|        P=0.588          (e)              (e)              (e)              P=0.529          (e)             | 
|COCH-ARM / FISHERS |        P=0.646          P=0.500N         P=0.500N         P=0.500N         P=0.500          P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       1/15 (7%)        0/15 (0%)        1/15 (7%)        1/15 (7%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        2/13.43          1/14.34          0/15.00          1/15.00          1/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        14.9%            7.0%             0.0%             6.7%             7.0%             0.0%            | 
|TERMINAL (d)       |        2/12 (17%)       1/14 (7%)        0/15 (0%)        1/15 (7%)        1/12 (8%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        185 (T)          185 (T)          ---              185 (T)          185 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.290N         P=0.445N         P=0.188N         P=0.420N         P=0.500N         P=0.276N        | 
|POLY 3             |        P=0.251N         P=0.477N         P=0.206N         P=0.461N         P=0.475N         P=0.228N        | 
|POLY 1.5           |        P=0.242N         P=0.487N         P=0.216N         P=0.477N         P=0.485N         P=0.229N        | 
|POLY 6             |        P=0.264N         P=0.463N         P=0.195N         P=0.441N         P=0.467N         P=0.231N        | 
|LOGISTIC REGRESSION|        P=0.290N         P=0.445N         (e)              P=0.420N         P=0.500N         (e)             | 
|COCH-ARM / FISHERS |        P=0.230N         P=0.500N         P=0.241N         P=0.500N         P=0.500N         P=0.241N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Unilateral, Germinal Epithelium                                                                                          | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        1/15 (7%)        0/15 (0%)        2/15 (13%)       1/15 (7%)        4/15 (27%)      | 
|POLY-3 RATE (b)    |        1/13.95          1/14.34          0/15.00          2/15.00          1/14.39          4/14.38         | 
|POLY-3 PERCENT (g) |        7.2%             7.0%             0.0%             13.3%            7.0%             27.8%           | 
|TERMINAL (d)       |        0/12 (0%)        1/14 (7%)        0/15 (0%)        2/15 (13%)       1/12 (8%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        145              185 (T)          ---              185 (T)          185 (T)          138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.013 *        P=0.743N         P=0.486N         P=0.560          P=0.753N         P=0.170         | 
|POLY 3             |        P=0.024 *        P=0.755N         P=0.486N         P=0.526          P=0.754N         P=0.170         | 
|POLY 1.5           |        P=0.024 *        P=0.757N         P=0.491N         P=0.515          P=0.756N         P=0.168         | 
|POLY 6             |        P=0.022 *        P=0.751N         P=0.479N         P=0.538          P=0.753N         P=0.170         | 
|LOGISTIC REGRESSION|        P=0.033 *        P=0.732          P=0.981N         P=0.310          P=0.653          P=0.111         | 
|COCH-ARM / FISHERS |        P=0.025 *        P=0.759N         P=0.500N         P=0.500          P=0.759N         P=0.165         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Unilateral, Germinal Epithelium                                                                                          | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/15 (27%)       1/15 (7%)        2/15 (13%)       0/15 (0%)        4/14 (29%)       5/14 (36%)      | 
|POLY-3 RATE (b)    |        4/15.00          1/14.34          2/15.00          0/15.00          4/13.68          5/14.00         | 
|POLY-3 PERCENT (g) |        26.7%            7.0%             13.3%            0.0%             29.2%            35.7%           | 
|TERMINAL (d)       |        1/12 (8%)        1/14 (7%)        2/15 (13%)       0/15 (0%)        2/11 (18%)       1/10 (10%)      | 
|FIRST INCIDENCE    |        132              185 (T)          185 (T)          ---              166              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.042 *        P=0.165N         P=0.274N         P=0.053N         P=0.628N         P=0.490         | 
|POLY 3             |        P=0.046 *        P=0.177N         P=0.327N         P=0.045N*        P=0.601          P=0.452         | 
|POLY 1.5           |        P=0.045 *        P=0.171N         P=0.327N         P=0.045N*        P=0.607          P=0.452         | 
|POLY 6             |        P=0.047 *        P=0.182N         P=0.327N         P=0.045N*        P=0.591          P=0.452         | 
|LOGISTIC REGRESSION|        P=0.058          P=0.237N         P=0.274N         (e)              P=0.410          (e)             | 
|COCH-ARM / FISHERS |        P=0.047 *        P=0.165N         P=0.326N         P=0.050N         P=0.617          P=0.450         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/15 (20%)       0/15 (0%)        2/15 (13%)       2/14 (14%)       3/14 (21%)       6/15 (40%)      | 
|POLY-3 RATE (b)    |        3/15.00          0/14.05          2/14.00          2/13.91          3/14.00          6/14.66         | 
|POLY-3 PERCENT (g) |        20.0%            0.0%             14.3%            14.4%            21.4%            40.9%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/11 (0%)        1/12 (8%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        63               ---              109              167              85               27              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.009 **       P=0.120N         P=0.507N         P=0.468N         P=0.625N         P=0.207         | 
|POLY 3             |        P=0.012 *        P=0.118N         P=0.533N         P=0.536N         P=0.637          P=0.202         | 
|POLY 1.5           |        P=0.012 *        P=0.116N         P=0.533N         P=0.534N         P=0.637          P=0.208         | 
|POLY 6             |        P=0.011 *        P=0.119N         P=0.533N         P=0.539N         P=0.637          P=0.194         | 
|LOGISTIC REGRESSION|        P=0.035 *        P=0.136N         P=0.485N         (e)              (e)              P=0.778N        | 
|COCH-ARM / FISHERS |        P=0.011 *        P=0.112N         P=0.500N         P=0.535N         P=0.639          P=0.213         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        3/14 (21%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          0/13.39          3/12.75         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             23.5%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/11 (0%)        3/10 (30%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.083         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.093         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.093         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.092         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.083         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.100         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        0/14 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/13.49          0/13.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/11 (0%)        0/12 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus: Thymocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/14 (14%)       0/14 (0%)       | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          0/15.00          2/13.72          0/12.75         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             14.6%            0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/11 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              163              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.382          (e)              (e)              (e)              P=0.273          (e)             | 
|POLY 3             |        P=0.355          (e)              (e)              (e)              P=0.235          (e)             | 
|POLY 1.5           |        P=0.373          (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 6             |        P=0.328          (e)              (e)              (e)              P=0.245          (e)             | 
|LOGISTIC REGRESSION|        P=0.406          (e)              (e)              (e)              P=0.162          (e)             | 
|COCH-ARM / FISHERS |        P=0.397          (e)              (e)              (e)              P=0.224          (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus: Thymocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        2/15 (13%)       2/14 (14%)       0/14 (0%)        5/15 (33%)      | 
|POLY-3 RATE (b)    |        0/12.95          1/15.00          2/14.20          2/13.86          0/13.03          5/13.31         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             14.1%            14.4%            0.0%             37.6%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/11 (0%)        0/12 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              67               5                167              ---              98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       P=0.514          P=0.240          P=0.265          (e)              P=0.026 *       | 
|POLY 3             |        P=0.008 **       P=0.529          P=0.253          P=0.247          (e)              P=0.017 *       | 
|POLY 1.5           |        P=0.009 **       P=0.523          P=0.249          P=0.241          (e)              P=0.017 *       | 
|POLY 6             |        P=0.008 **       P=0.532          P=0.254          P=0.248          (e)              P=0.017 *       | 
|LOGISTIC REGRESSION|        P=0.028 *        P=0.327          P=0.244          P=0.198          (e)              P=0.032 *       | 
|COCH-ARM / FISHERS |        P=0.011 *        P=0.500          P=0.241          P=0.224          (e)              P=0.021 *       | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        1/12.95          0/14.05          0/12.72          0/14.49          0/14.03          2/10.72         | 
|POLY-3 PERCENT (g) |        7.7%             0.0%             0.0%             0.0%             0.0%             18.7%           | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        186 (T)          ---              ---              ---              ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.051          P=0.469N         P=0.500N         P=0.500N         P=0.484N         P=0.396         | 
|POLY 3             |        P=0.082          P=0.484N         P=0.504N         P=0.478N         P=0.484N         P=0.432         | 
|POLY 1.5           |        P=0.083          P=0.488N         P=0.503N         P=0.480N         P=0.487N         P=0.458         | 
|POLY 6             |        P=0.082          P=0.481N         P=0.507N         P=0.480N         P=0.483N         P=0.405         | 
|LOGISTIC REGRESSION|        P=0.051          (e)              (e)              (e)              (e)              P=0.396         | 
|COCH-ARM / FISHERS |        P=0.091          P=0.500N         P=0.500N         P=0.500N         P=0.500N         P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -         PENTAERYTHRITOL TRIACRYLATE (
PETA)                                                                                                                               
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/15 (73%)      9/15 (60%)       7/15 (47%)       10/15 (67%)      11/15 (73%)      7/15 (47%)      | 
|POLY-3 RATE (b)    |        11/12.95         9/14.05          7/12.72          10/14.49         11/14.10         7/10.72         | 
|POLY-3 PERCENT (g) |        84.9%            64.1%            55.1%            69.0%            78.0%            65.3%           | 
|TERMINAL (d)       |        11/12 (92%)      9/14 (64%)       7/12 (58%)       10/12 (83%)      10/13 (77%)      7/9 (78%)       | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          186 (T)          186 (T)          182              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.422          P=0.123N         P=0.083N         P=0.500N         P=0.516N         P=0.396N        | 
|POLY 3             |        P=0.532N         P=0.212N         P=0.101N         P=0.295N         P=0.514N         P=0.250N        | 
|POLY 1.5           |        P=0.420N         P=0.241N         P=0.105N         P=0.325N         P=0.546N         P=0.175N        | 
|POLY 6             |        P=0.470          P=0.193N         P=0.108N         P=0.305N         P=0.492N         P=0.372N        | 
|LOGISTIC REGRESSION|        P=0.433          P=0.123N         P=0.083N         P=0.500N         P=0.450N         P=0.396N        | 
|COCH-ARM / FISHERS |        P=0.249N         P=0.350N         P=0.132N         P=0.500N         P=0.659N         P=0.132N        | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).