National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4935

TDMS Study 88127-06 Pathology Tables

NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18

                                                            Final#2




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  3524-68-3

       Lock Date:  06/16/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                      2                         3            3            2            3           
    Moribund Sacrifice                                 1            1                                                   3           
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           14           12           12           13            9           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                                        1 [1.0]      1 [2.0]      6 [1.5]     
      Infiltration Cellular                                                                                3 [1.7]      2 [1.5]     
      Inflammation, Chronic Active                    12 [1.0]     14 [1.0]     11 [1.0]     14 [1.0]     13 [1.2]     11 [1.2]     
      Necrosis                                                                                                          1 [1.0]     
      Pigmentation                                    11 [1.0]     11 [1.0]      9 [1.0]     13 [1.0]      5 [1.0]      2 [1.0]     
      Bile Duct, Hyperplasia                                                                               1 [2.0]                  
      Hepatocyte, Necrosis                             2 [1.0]      2 [1.0]      2 [1.0]      3 [1.0]      4 [1.0]      2 [1.5]     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperkeratosis                                   1 [2.0]                   3 [2.0]      3 [2.0]      4 [2.0]      4 [1.8]     
      Inflammation                                                                                         2 [2.0]                  
      Epithelium, Hyperplasia                          1 [2.0]                                             2 [3.0]                  
      Epithelium, Ulcer                                                                                    1 [2.0]                  
   Tooth                                              (4)                       (3)          (3)          (1)                       
      Inflammation, Chronic Active                                                            1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             1 [1.0]     
      Inflammation, Chronic Active                                  1 [1.0]                                             1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                                                                  1 [1.0]     
      Necrosis                                                                                                          1 [1.0]     
      Capsule, Hyperplasia                             1 [2.0]      4 [1.0]      7 [1.0]      2 [1.0]      1 [1.0]      2 [1.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (15)         (15)         (14)         (15)         (15)         (15)         
      Pars Distalis, Cyst                              3 [1.0]                   2 [1.0]      2 [1.0]      4 [1.0]      2 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Cyst                                             1 [2.0]                                1 [2.0]      2 [2.0]                  
   Uterus                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hydrometra                                       1 [2.0]                                                          2 [2.0]     
      Endometrium, Hyperplasia, Cystic                11 [1.5]      9 [1.7]      7 [1.9]     10 [1.9]     11 [1.5]      7 [1.9]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (15)         (14)         (13)         (12)         (15)         (14)         
      Hematopoietic Cell Proliferation                                                                                  2 [1.0]     
      Inguinal, Hematopoietic Cell Proliferation                                                                        1 [1.0]     
      Inguinal, Hyperplasia                                                                                             1 [2.0]     
      Inguinal, Infiltration Cellular                                                                                   1 [2.0]     
      Inguinal, Infiltration Cellular, Plasma Cell                                                                      1 [2.0]     
      Mediastinal, Hematopoietic Cell Proliferation                                                                     1 [2.0]     
      Mediastinal, Hyperplasia                                                                                          1 [2.0]     
      Mediastinal, Infiltration Cellular                                                                   3 [1.3]      1 [3.0]     
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                                                          1 [3.0]     
      Mediastinal, Necrosis, Lymphoid                                            1 [1.0]                                            
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)         (13)         
      Hematopoietic Cell Proliferation                                                                     1 [2.0]      8 [1.8]     
      Hyperplasia                                      3 [2.0]                   1 [4.0]      5 [2.4]      3 [2.0]      1 [2.0]     
      Infiltration Cellular                                                                   1 [2.0]      2 [2.5]      2 [2.5]     
      Infiltration Cellular, Plasma Cell                                                                   1 [3.0]      1 [3.0]     
      Necrosis, Lymphoid                                            1 [2.0]      1 [1.0]                                            
   Lymph Node, Mesenteric                             (14)         (15)         (15)         (14)         (15)         (15)         
      Infiltration Cellular                                                                                4 [1.8]                  
      Necrosis, Lymphoid                                            1 [3.0]                                                         
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Depletion Cellular                               2 [2.0]      1 [3.0]      2 [2.5]      1 [3.0]      2 [2.5]      3 [2.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                                                        2 [2.0]     11 [2.2]     11 [2.5]     
      Infiltration Cellular                                                                                1 [1.0]      1 [2.0]     
      Necrosis, Lymphoid                                            1 [2.0]      1 [2.0]                   1 [2.0]                  
   Thymus                                             (15)         (15)         (15)         (14)         (14)         (15)         
      Atrophy                                          3 [3.3]                   2 [2.5]      2 [3.0]      3 [3.0]      6 [2.7]     
      Pigmentation                                                                            1 [2.0]                               
      Thymocyte, Necrosis                                           1 [4.0]      2 [3.5]      2 [2.0]                   5 [2.4]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                            5 [1.2]     14 [2.0]     14 [2.4]     14 [2.9]     
      Epidermis, Skin, Site of Application, Ulcer                                                                       1 [2.0]     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia, Adenomatous                                                                        1 [2.0]                  
      Skin, Site of Application, Cyst Epithelial                                                                                    
          Inclusion                                                                                        1            1           
      Skin, Site of Application, Hyperkeratosis        1 [2.0]                   4 [1.5]     14 [1.6]     11 [1.5]     13 [2.0]     
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                                        1 [1.0]      9 [1.1]     10 [1.7]     15 [1.5]     
      Subcutaneous Tissue, Hemorrhage                                                         1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             1 [2.0]     
      Infiltration Cellular, Mononuclear Cell                                    1 [2.0]                                            
      Inflammation, Chronic Active                                                            1 [1.0]                   1 [1.0]     
      Alveolar Epithelium, Hyperplasia                                                                     1 [2.0]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                     1 [1.0]      2 [1.5]      1 [3.0]      1 [3.0]      1 [1.0]      1 [1.0]     
      Nephropathy                                      3 [1.0]                                                          2 [1.0]     
      Polyarteritis                                    1 [3.0]                                                                      
      Cortex, Cyst                                                                                                      2 [1.5]     
      Papilla, Necrosis                                                          1 [4.0]                                            
      Renal Tubule, Degeneration                                                                                        1 [2.0]     
      Renal Tubule, Hyperplasia                                                  1 [1.0]      1 [4.0]                               
      Renal Tubule, Necrosis                                                                                            2 [2.0]     
      Renal Tubule, Regeneration                       1 [1.0]      1 [1.0]                   2 [1.0]      1 [1.0]                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                      3                                                   2            5           
    Moribund Sacrifice                                              1                                      1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           14           15           15           12           10           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                          1 [4.0]                                                                      
      Hematopoietic Cell Proliferation                                                                     2 [1.5]                  
      Infiltration Cellular                                                                                5 [1.2]      3 [1.3]     
      Inflammation, Chronic Active                     5 [1.0]     11 [1.0]     10 [1.0]     13 [1.0]     13 [1.1]      5 [1.0]     
      Mineralization                                   1 [2.0]                                                                      
      Myelodysplasia                                                                                                    5 [2.6]     
      Pigmentation                                                  1 [1.0]      1 [1.0]                                            
      Hepatocyte, Necrosis                             1 [1.0]                   1 [1.0]                   1 [1.0]      1 [1.0]     
      Hepatocyte, Vacuolization Cytoplasmic                                      1 [2.0]                                            
   Salivary Glands                                    (1)          (1)                       (1)                       (2)          
      Parotid Gland, Infiltration Cellular                                                                              1 [2.0]     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperkeratosis                                   2 [2.0]                   1 [2.0]                   3 [2.0]      4 [2.0]     
      Epithelium, Hyperplasia                                                    1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             3 [1.3]     
      Inflammation, Chronic Active                                  3 [1.0]                                1 [1.0]                  
      Myelodysplasia                                                                                                    3 [1.3]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)         (15)         (15)         
      Hypertrophy                                      7 [1.1]     10 [1.4]      3 [1.3]      5 [1.2]      1 [1.0]      3 [1.3]     
      Myelodysplasia                                                                                                    2 [1.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Medulla                                    (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             2 [2.5]     
      Myelodysplasia                                                                                                    2 [1.5]     
   Pituitary Gland                                    (15)         (14)         (15)         (15)         (15)         (15)         
      Pars Distalis, Cyst                              1 [1.0]                                             3 [1.0]                  
   Thyroid Gland                                      (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                                                                         1 [1.0]                  
      Myelodysplasia                                                                                                    1 [1.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (14)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                5 [1.0]      5 [2.4]     
      Inflammation, Chronic Active                                  1 [1.0]                                             4 [1.3]     
      Myelodysplasia                                                                                                    5 [2.2]     
      Bilateral, Hypospermia                                                                                            1 [3.0]     
      Unilateral, Hypospermia                          1 [3.0]      1 [3.0]                                             2 [3.0]     
   Preputial Gland                                                                                                     (1)          
      Duct, Ectasia                                                                                                     1 [2.0]     
   Testes                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Cyst                                             2 [1.5]      1 [2.0]                   1 [2.0]      1 [3.0]                  
      Bilateral, Germinal Epithelium, Degeneration                                                         1 [2.0]                  
      Unilateral, Germinal Epithelium, Degeneration    1 [2.0]      1 [3.0]                   2 [2.0]      1 [3.0]      4 [2.5]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                                                                                         (1)          
      Myeloid Cell, Hyperplasia                                                                                         1 [3.0]     
   Lymph Node                                         (14)         (15)         (14)         (13)         (15)         (14)         
      Hyperplasia                                                                                          1 [2.0]                  
      Infiltration Cellular, Plasma Cell                                                                   1 [2.0]                  
      Inflammation, Chronic Active                                                                         1 [3.0]                  
      Myelodysplasia                                                                                                    1 [2.0]     
      Axillary, Hyperplasia, Lymphoid                                                                                   1 [3.0]     
      Axillary, Infiltration Cellular                                                                      1 [3.0]      1 [2.0]     
      Axillary, Infiltration Cellular, Plasma Cell                                                         1 [3.0]      1 [2.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Axillary, Infiltration Cellular, Histiocyte                                                                       1 [2.0]     
      Inguinal, Myelodysplasia                                                                                          1 [2.0]     
      Mediastinal, Hyperplasia                                                                             1 [2.0]                  
      Mediastinal, Infiltration Cellular                                                                   4 [1.5]      2 [2.5]     
      Mediastinal, Myelodysplasia                                                                                       1 [2.0]     
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                                                     3 [1.7]                  
      Hyperplasia                                                                2 [2.0]      1 [2.0]      2 [2.0]                  
      Hyperplasia, Plasma Cell                                                                                          1 [3.0]     
      Infiltration Cellular                                                                                5 [2.0]      6 [2.0]     
      Infiltration Cellular, Plasma Cell                                                                   1 [2.0]      6 [2.0]     
      Myelodysplasia                                                                                                    2 [1.5]     
      Necrosis, Lymphoid                                                                                   2 [1.5]                  
   Lymph Node, Mesenteric                             (12)         (15)         (15)         (15)         (15)         (14)         
      Hematopoietic Cell Proliferation                                                                     1 [2.0]      1 [2.0]     
      Infiltration Cellular                                                                                4 [1.8]      2 [2.0]     
      Myelodysplasia                                                                                                    3 [2.3]     
      Necrosis, Lymphoid                                                                                   1 [2.0]                  
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                          1 [3.0]                                                                      
      Depletion Cellular                                                                                   2 [2.5]      2 [2.0]     
      Hematopoietic Cell Proliferation                 1 [2.0]      2 [2.0]      1 [2.0]      2 [2.0]      9 [2.1]      8 [2.5]     
      Infiltration Cellular                                                                                1 [1.0]      4 [1.8]     
      Myelodysplasia                                                                                                    4 [2.8]     
      Necrosis, Lymphoid                                                                                   2 [2.0]      1 [2.0]     
   Thymus                                             (15)         (15)         (15)         (15)         (14)         (14)         
      Atrophy                                          4 [2.3]      1 [2.0]      2 [3.5]                   4 [2.5]      5 [2.6]     
      Myelodysplasia                                                                                                    3 [2.0]     
      Thymocyte, Necrosis                                                                                  2 [2.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Dermis, Skin, Site of Application, Necrosis                                                                       1 [4.0]     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                            3 [1.0]      8 [1.8]     10 [1.9]     14 [2.4]     
      Epidermis, Skin, Site of Application, Ulcer                                                          1 [2.0]                  
      Skin, Site of Application, Cyst Epithelial                                                                                    
          Inclusion                                                                                                     1           
      Skin, Site of Application, Hyperkeratosis        1 [2.0]                   2 [2.0]      6 [1.0]     10 [1.8]     13 [1.5]     
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                                                     2 [1.0]      5 [1.2]     12 [1.3]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88127-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                               PENTAERYTHRITOL TRIACRYLATE (PETA)                          Time: 08:42:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                1 [1.0]      3 [1.3]     
      Inflammation, Chronic Active                                                                         1 [1.0]      2 [1.5]     
      Myelodysplasia                                                                                                    3 [2.3]     
      Alveolar Epithelium, Hyperplasia                                           1 [2.0]                                            
      Mediastinum, Infiltration Cellular                                                                                1 [2.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hydronephrosis                                                                                                    1 [2.0]     
      Infarct                                                                    1 [3.0]      2 [3.0]                               
      Infiltration Cellular                                                                                2 [1.5]      3 [1.3]     
      Inflammation, Chronic Active                     1 [1.0]                   4 [1.3]      4 [1.5]      3 [1.3]                  
      Mineralization                                                                                       1 [1.0]                  
      Myelodysplasia                                                                                                    4 [1.8]     
      Nephropathy                                      6 [1.0]      1 [1.0]                                                         
      Pigmentation                                     1 [1.0]                                                                      
      Cortex, Cyst                                                  1 [2.0]                   1 [2.0]      1 [2.0]      1 [1.0]     
      Renal Tubule, Dilatation                                                                1 [2.0]                               
      Renal Tubule, Regeneration                       1 [1.0]      2 [1.0]                   3 [1.7]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.