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TDMS Study 88133-03 Pathology Tables

NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99
Route: SKIN APPLICATION                                                                                           Time: 08:54:42

                                                       13 WEEK SUBCHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  15625-89-5

       Lock Date:  10/09/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (2)          (1)          (3)          (1)          (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)      2 (100%)     1 (100%)     3 (100%)     1 (100%)     4 (40%)     
      Inflammation                                                                                                      1 (10%)     
      Inflammation, Chronic Active                     9 (90%)                                                          9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)                                                             (10)         
      Ultimobranchial Cyst                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (1)          (1)          (1)                       (10)         
      Inflammation, Chronic                            1 (10%)      1 (100%)     1 (100%)     1 (100%)                              
   Uterus                                             (10)                      (1)          (1)                       (10)         
      Hydrometra                                       2 (20%)                   1 (100%)                               4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                             (10)         
      Pigmentation                                     2 (20%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Dermis, Skin, Site of Application, Granuloma                                                         1 (10%)                  
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                 1 (10%)      2 (20%)      1 (10%)      9 (90%)      8 (80%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                                                        4 (40%)      7 (70%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                                         7 (70%)     10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Suppurative                                                                                     6 (60%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                                                      5 (50%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                              1 (10%)      6 (60%)      9 (90%)     10 (100%)    10 (100%)    
      Skin, Site of Application, Hyperkeratosis                                  3 (30%)      9 (90%)     10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
      Inflammation, Chronic Active                     4 (40%)                                                          2 (20%)     
   Nose                                               (10)                                                             (10)         
      Respiratory Epithelium, Metaplasia, Squamous                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                                    (1)                       
      Atrophy                                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                      1 (10%)                                                          1 (10%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (10)                                                             (10)         
      Hyperplasia, Lymphoid                                                                                             1 (10%)     
   Liver                                              (10)         (2)          (1)          (1)          (3)          (10)         
      Hepatodiaphragmatic Nodule                                    2 (100%)     1 (100%)     1 (100%)     3 (100%)     1 (10%)     
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Vacuolization Cytoplasmic                        2 (20%)                                                          2 (20%)     
   Pancreas                                           (10)                                                             (10)         
      Atrophy                                          1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   5 (50%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)                                                             (10)         
      Hyperplasia, Focal                               1 (10%)                                                                      
   Thyroid Gland                                      (10)                                                             (10)         
      Ultimobranchial Cyst                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)                                                             (10)         
      Inflammation, Chronic Active                                                                                      1 (10%)     
   Prostate                                           (10)                                                             (10)         
      Inflammation, Chronic Active                                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                             (10)         
      Ectasia, Lymphoid                                                                                                 1 (10%)     
   Lymph Node, Mesenteric                             (10)                                                             (10)         
      Hyperplasia, Lymphoid                                                                                             1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Dermis, Inflammation, Chronic Active             2 (20%)      1 (10%)                   1 (10%)                               
      Dermis, Skin, Site of Application, Fibrosis                                                                       1 (10%)     
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                              1 (10%)      3 (30%)      6 (60%)     10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                                           4 (40%)      7 (70%)      9 (90%)      8 (80%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               4 (40%)      7 (70%)     10 (100%)    10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Suppurative                                                                                     4 (40%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                            1 (10%)                   1 (10%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                                           5 (50%)     10 (100%)    10 (100%)    10 (100%)    
      Skin, Site of Application, Degeneration                                                 1 (10%)                               
      Skin, Site of Application, Hyperkeratosis                                  5 (50%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                                                     (1)          
      Abdominal, Inflammation, Chronic                                                                                  1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (1)                                    (1)          (10)         
      Hemorrhage                                       1 (10%)      1 (100%)                               1 (100%)                 
      Inflammation                                     1 (10%)                                                                      
      Inflammation, Chronic Active                                  1 (100%)                                            2 (20%)     
   Nose                                               (10)                                                             (10)         

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Developmental                                                                                         
          Malformation                                                                                                  1 (10%)     
   Trachea                                            (10)         (1)                                                 (10)         
      Hemorrhage                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                       (1)                                    
      Atrophy                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                                                                                       3 (30%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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