https://ntp.niehs.nih.gov/go/4939

TDMS Study 88133-03 Pathology Tables

NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99
Route: SKIN APPLICATION                                                                                           Time: 08:54:42
                                                       13 WEEK SUBCHRONIC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  15625-89-5
       Lock Date:  10/09/97
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (2)          (1)          (3)          (1)          (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)      2 (100%)     1 (100%)     3 (100%)     1 (100%)     4 (40%)     
      Inflammation                                                                                                      1 (10%)     
      Inflammation, Chronic Active                     9 (90%)                                                          9 (90%)     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Thyroid Gland                                      (10)                                                             (10)         
      Ultimobranchial Cyst                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (10)         (1)          (1)          (1)                       (10)         
      Inflammation, Chronic                            1 (10%)      1 (100%)     1 (100%)     1 (100%)                              
   Uterus                                             (10)                      (1)          (1)                       (10)         
      Hydrometra                                       2 (20%)                   1 (100%)                               4 (40%)     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (10)                                                             (10)         
      Pigmentation                                     2 (20%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Dermis, Skin, Site of Application, Granuloma                                                         1 (10%)                  
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                 1 (10%)      2 (20%)      1 (10%)      9 (90%)      8 (80%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                                                        4 (40%)      7 (70%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                                         7 (70%)     10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Suppurative                                                                                     6 (60%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                                                      5 (50%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                              1 (10%)      6 (60%)      9 (90%)     10 (100%)    10 (100%)    
      Skin, Site of Application, Hyperkeratosis                                  3 (30%)      9 (90%)     10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                                             (10)         
      Inflammation, Chronic Active                     4 (40%)                                                          2 (20%)     
   Nose                                               (10)                                                             (10)         
      Respiratory Epithelium, Metaplasia, Squamous                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Eye                                                                                                    (1)                       
      Atrophy                                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                      1 (10%)                                                          1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Small, Ileum                             (10)                                                             (10)         
      Hyperplasia, Lymphoid                                                                                             1 (10%)     
   Liver                                              (10)         (2)          (1)          (1)          (3)          (10)         
      Hepatodiaphragmatic Nodule                                    2 (100%)     1 (100%)     1 (100%)     3 (100%)     1 (10%)     
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Vacuolization Cytoplasmic                        2 (20%)                                                          2 (20%)     
   Pancreas                                           (10)                                                             (10)         
      Atrophy                                          1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   5 (50%)                                                          4 (40%)     
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Pituitary Gland                                    (10)                                                             (10)         
      Hyperplasia, Focal                               1 (10%)                                                                      
   Thyroid Gland                                      (10)                                                             (10)         
      Ultimobranchial Cyst                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (10)                                                             (10)         
      Inflammation, Chronic Active                                                                                      1 (10%)     
   Prostate                                           (10)                                                             (10)         
      Inflammation, Chronic Active                                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node, Mandibular                             (10)                                                             (10)         
      Ectasia, Lymphoid                                                                                                 1 (10%)     
   Lymph Node, Mesenteric                             (10)                                                             (10)         
      Hyperplasia, Lymphoid                                                                                             1 (10%)     
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Dermis, Inflammation, Chronic Active             2 (20%)      1 (10%)                   1 (10%)                               
      Dermis, Skin, Site of Application, Fibrosis                                                                       1 (10%)     
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                              1 (10%)      3 (30%)      6 (60%)     10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                                           4 (40%)      7 (70%)      9 (90%)      8 (80%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               4 (40%)      7 (70%)     10 (100%)    10 (100%)    10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Suppurative                                                                                     4 (40%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                            1 (10%)                   1 (10%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                                           5 (50%)     10 (100%)    10 (100%)    10 (100%)    
      Skin, Site of Application, Degeneration                                                 1 (10%)                               
      Skin, Site of Application, Hyperkeratosis                                  5 (50%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                                                                                     (1)          
      Abdominal, Inflammation, Chronic                                                                                  1 (100%)    
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (1)                                    (1)          (10)         
      Hemorrhage                                       1 (10%)      1 (100%)                               1 (100%)                 
      Inflammation                                     1 (10%)                                                                      
      Inflammation, Chronic Active                                  1 (100%)                                            2 (20%)     
   Nose                                               (10)                                                             (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88133-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           TRIMETHYLOLPROPANE TRIACRYLATE                              Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:54:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Developmental                                                                                         
          Malformation                                                                                                  1 (10%)     
   Trachea                                            (10)         (1)                                                 (10)         
      Hemorrhage                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Eye                                                                                       (1)                                    
      Atrophy                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                                                                                       3 (30%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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