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TDMS Study 88133-06 Pathology Tables

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                                                                           TIME: 13:07:47

                                                         EIS REPORT 43


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  88133B

       CONTRACT NUMBER:  NO1-ES-65406

       CAS NUMBER:  15625-89-5

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    2                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 0 MG/KG                                           LAST OBS:
------------------------------------------------------------------------------------------------------------------------------------





                              THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 3
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    4                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 0.75    MG/KG                                     LAST OBS:
------------------------------------------------------------------------------------------------------------------------------------





                              THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 4
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    6                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 1.5     MG/KG                                     LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       19     20     21     22     23     24     25     26     27     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0308        308      1      1      1      1      1      1      1      1      1      1

SURVIVORS           12     12     12     12     12     12     12     12     12     12
NO. W/TUMORS         1      1      1      1      1      1      1      1      1      1
TOTAL TUMORS         1      1      1      1      1      1      1      1      1      1
MEAN/SURVIVOR      0.1    0.1    0.1    0.1    0.1    0.1    0.1    0.1    0.1    0.1
MEAN W/TUMORS      1.0    1.0    1.0    1.0    1.0    1.0    1.0    1.0    1.0    1.0

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 5
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    8                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 3 MG/KG                                           LAST OBS:
------------------------------------------------------------------------------------------------------------------------------------





                              THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 6
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   10                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 6 MG/KG                                           LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:        9     10     11     13     14     15     16     17     18     19     20     21     22     23     24     25
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0332        332
0333        333                                                                                                 3      2      2
0334        334
0335        335                                         1      2      2      3      3      3      3      3      5      7      7
0336        336                                                                                                        3      4
0337        337
0339        339                                                                                                               3
0340        340                           1      1      1      1      1      2      1      1      1      1      1      1      1
0341        341                                                                                                        3      3
0342        342                                                                                                               1
0345        345      1      1      1                                                                                          R

SURVIVORS           15     15     15     15     15     15     15     15     15     15     15     15     15     15     15     14
NO. W/TUMORS         1      1      1      1      1      2      2      2      2      2      2      2      2      3      5      7
TOTAL TUMORS         1      1      1      1      1      2      3      3      5      4      4      4      4      9     16     21
MEAN/SURVIVOR      0.1    0.1    0.1    0.1    0.1    0.1    0.2    0.2    0.3    0.3    0.3    0.3    0.3    0.6    1.1    1.5
MEAN W/TUMORS      1.0    1.0    1.0    1.0    1.0    1.0    1.5    1.5    2.5    2.0    2.0    2.0    2.0    3.0    3.2    3.0

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 7
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   10                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 6 MG/KG                                           LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       26     27     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0332        332      1
0333        333      2      2      2
0334        334                    3
0335        335      7     12     10
0336        336      4      4      4
0337        337                    3
0339        339      3      2      3
0340        340      1      1      2
0341        341      3      3      4
0342        342      1      1      2
0345        345

SURVIVORS           14     14     14
NO. W/TUMORS         8      7      9
TOTAL TUMORS        22     25     33
MEAN/SURVIVOR      1.6    1.8    2.4
MEAN W/TUMORS      2.8    3.6    3.7

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 8
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   12                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 12 MG/KG                                          LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       10     11     12     13     14     15     16     17     18     19     20     21     22     23     24     25
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0346        346                           7      9     10      9     15     20     20     22     20     20     20     20     20
0347        347                                  5      7      6      7      7      7      8      9     10     13     11      9
0348        348      1      1      3      3      4     10     10     15     20     20     20     20     20     20     20     20
0349        349                    2      3      3      6      8      8     20     20     20     20     20     20     20     20
0350        350      3      5      7      8     11     13     14     20     20     20     24     25     27     25     24     20
0351        351                                                7     10     10     10     13     10     12     16     20     20
0352        352                                  3      7      7     10     20     20     20     20     20     20     20     20
0353        353                           3      7      9     11     17      R
0354        354                                                7      7      7     15     15     12     20     20     20     20
0355        355                                               14     17     15     20     20     20     20     20     20     20
0356        356                                  8     10     11     20     20     20     20     20     20     20     20     20
0357        357                                  7      7     10     16     20     20     20     20     20     20     20     20
0358        358      1      1      1      2      1      9      5     13     20     20     20     20     20     20     20     20
0359        359                                                       8     10     15     15     20     20     20     20     20
0360        360                                        15     17     20     20     20     15     20     20     20     20     20

SURVIVORS           15     15     15     15     15     15     15     15     14     14     14     14     14     14     14     14
NO. W/TUMORS         3      3      4      6     10     11     14     15     14     14     14     14     14     14     14     14
TOTAL TUMORS         5      7     13     26     58    103    136    203    229    247    252    256    269    274    275    269
MEAN/SURVIVOR      0.3    0.5    0.9    1.7    3.9    6.9    9.1   13.5   16.4   17.6   18.0   18.3   19.2   19.6   19.6   19.2
MEAN W/TUMORS      1.7    2.3    3.3    4.3    5.8    9.4    9.7   13.5   16.4   17.6   18.0   18.3   19.2   19.6   19.6   19.2

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 9
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   12                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: 12 MG/KG                                          LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       26     27     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0346        346     20     20     20
0347        347     20     20     20
0348        348     20     20     20
0349        349     20     20     20
0350        350     26     28     29
0351        351     20     21     20
0352        352     20     20     20
0353        353
0354        354     20     20     20
0355        355             R
0356        356     20     20     20
0357        357     20     20     20
0358        358     20     20      R
0359        359     20     20     20
0360        360     20     20     20

SURVIVORS           14     13     12
NO. W/TUMORS        13     13     12
TOTAL TUMORS       266    269    249
MEAN/SURVIVOR     19.0   20.7   20.8
MEAN W/TUMORS     20.5   20.7   20.8

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 10
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   14                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: POSITIVETPA                                       LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:        9     10     11     12     13     14     15     16     17     18     19     20     21     22     23     24
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0376        376            20     20     20     20     20     20     20     20     20     20     20      R
0377        377      7      7      7     15     20     20     20     20     20     20     20     20      R
0378        378      3      4      6      4      1      1      6      6      5      5      3      3      4      3      6     10
0379        379     20     20     20     20     20     20     20     20     20     20     20     20     20      R
0380        380      3      7     13      7     20     20     20     20     20     13     20     20     15     15     20     15
0381        381            20     20     20     20     20     20     20     20     20     20     20     15     15     20     20
0384        384             5     10     10     12     13     13     20     20     20     15     20      9      4      3      5
0385        385                          18     20     20     20             R
0386        386            20     20     20     20     20     20     20     20     20     20     20     20     20     20     20
0387        387     20     20     20     20     20     20     20     20     20     20     20     20     20     20     20     20
0388        388                                 20     20     20     20     20     20     20     20     20     20     20     20
0389        389                   20     20     20     20     20     12     12     12     10     10      6      6      4      4

SURVIVORS           14     14     14     14     14     14     14     14     13     13     13     13     11     10     10     10
NO. W/TUMORS         5      9     10     11     12     12     12     11     11     11     11     11      9      8      8      8
TOTAL TUMORS        53    123    156    174    213    214    219    198    197    190    188    193    129    103    113    114
MEAN/SURVIVOR      3.8    8.8   11.1   12.4   15.2   15.3   15.6   14.1   15.2   14.6   14.5   14.8   11.7   10.3   11.3   11.4
MEAN W/TUMORS     10.6   13.7   15.6   15.8   17.8   17.8   18.3   18.0   17.9   17.3   17.1   17.5   14.3   12.9   14.1   14.3

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 11
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   14                                            FIRST DOSE: 07/20/98
           SEX: FEMALE                                     TRT: POSITIVETPA                                       LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       25     26     27     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0376        376
0377        377
0378        378      5      7     11     14
0379        379
0380        380     11     16     15     12
0381        381     20     20     20     20
0384        384      5     13      4      3
0385        385
0386        386     20     20     20     20
0387        387     20     20     20     20
0388        388     20     20     20     20
0389        389      6      4      4      4

SURVIVORS           10     10     10     10
NO. W/TUMORS         8      8      8      8
TOTAL TUMORS       107    120    114    113
MEAN/SURVIVOR     10.7   12.0   11.4   11.3
MEAN W/TUMORS     13.4   15.0   14.3   14.1

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 12
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    1                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: 0 MG/KG                                           LAST OBS:
------------------------------------------------------------------------------------------------------------------------------------





                              THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 13
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    3                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: 0.75    MG/KG                                     LAST OBS:
------------------------------------------------------------------------------------------------------------------------------------





                              THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 14
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    5                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: 1.5     MG/KG                                     LAST OBS:
------------------------------------------------------------------------------------------------------------------------------------





                              THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 15
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    7                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: 3 MG/KG                                           LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       23     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0229        229             1
0232        232      1

SURVIVORS           14     14
NO. W/TUMORS         1      1
TOTAL TUMORS         1      1
MEAN/SURVIVOR      0.1    0.1
MEAN W/TUMORS      1.0    1.0

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 16
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:    9                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: 6 MG/KG                                           LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       14     15     16     17     18     19     20     21     22     23     24     25     26     27     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0241        241                           2      2      2      2      3      3      4      4      4      4      4      3
0243        243                                         9     11      8     13     12     13     13     20      R
0245        245                                         2      1      2      2      2      2      2
0246        246                           1                                                              3      3      3
0247        247                                                              1      2      2      3      3      6      6
0248        248      1      1      1      1      1      1      1      2      2      8      8      8      8     13     12
0249        249                                                                     6      5      6      7      6      6
0250        250                                         1      1      1      2      3      4      6      7      8      8
0251        251                                                                     2      2      2      3      5      4
0252        252                                                4      5      9      7      9     15     15     20     20
0254        254                    7      6      6      6      8     14     16     20     16     20     20     20     20
0255        255                                                                                   4      4      6      8

SURVIVORS           15     14     14     14     14     14     14     14     14     14     14     14     14     13     13
NO. W/TUMORS         1      1      2      4      3      6      7      7      8     10     10     11     11     10     10
TOTAL TUMORS         1      1      8     10      9     21     28     35     48     66     65     83     94     91     90
MEAN/SURVIVOR      0.1    0.1    0.6    0.7    0.6    1.5    2.0    2.5    3.4    4.7    4.6    5.9    6.7    7.0    6.9
MEAN W/TUMORS      1.0    1.0    4.0    2.5    3.0    3.5    4.0    5.0    6.0    6.6    6.5    7.5    8.5    9.1    9.0

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 17
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   11                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: 12 MG/KG                                          LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:        9     10     11     12     13     14     15     16     17     18     19     20     21     22     23     24
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0256        256                                  5      9     12     14     20     20     20     20     20     20     20     20
0258        258                                  1      1      3      3      6     12     10     15     20     15     20      R
0259        259                                                7     12     15     16     18     15     20     20     20     20
0260        260      3      2      3      3      8      8     11     10     13     13     17     20     20     20     20     20
0261        261                                                      16     20     20     20     20     20     20     20     20
0262        262                                  5      6      9      9     13     15     14     20     20     20     20     20
0263        263             1      1      1      1      3      3      5      7     15     20     20     22     20     20     22
0265        265                           1      2      3      5      5      5      6      7      6      4      7     13     20
0266        266             3      2      7      7      6     11     12     13     20     20     20     20     20     20      R
0267        267                                                5     10     14     20     20     20     20     20     20     20
0268        268                                         7     12     13     17     20     20     20     20     20     20     21
0269        269             4      3      4      5      4     12     11     15     20     20     20     20     20     20     20
0270        270                           5      6      8     12     10     12     13     16     20     20     23     23     22

SURVIVORS           15     15     15     15     15     15     15     15     15     15     15     15     15     15     15     13
NO. W/TUMORS         1      4      4      6      9     10     12     13     13     13     13     13     13     13     13     11
TOTAL TUMORS         3     10      9     21     40     55    102    130    170    210    222    236    246    245    256    225
MEAN/SURVIVOR      0.2    0.7    0.6    1.4    2.7    3.7    6.8    8.7   11.3   14.0   14.8   15.7   16.4   16.3   17.1   17.3
MEAN W/TUMORS      3.0    2.5    2.3    3.5    4.4    5.5    8.5   10.0   13.1   16.2   17.1   18.2   18.9   18.8   19.7   20.5

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 18
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   11                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: 12 MG/KG                                          LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       25     26     27     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0256        256     20     20     20     20
0258        258
0259        259     20     20     20     20
0260        260     20     20     20     20
0261        261     20     20     20     20
0262        262     20     20     20     20
0263        263     20     21     23     25
0265        265     20     20     20     20
0266        266
0267        267     20     20     20     20
0268        268     21     21     21     21
0269        269     20     20      R
0270        270     22     28     25     29

SURVIVORS           13     13     12     12
NO. W/TUMORS        11     11     10     10
TOTAL TUMORS       223    230    209    215
MEAN/SURVIVOR     17.2   17.7   17.4   17.9
MEAN W/TUMORS     20.3   20.9   20.9   21.5

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 19
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   13                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: POSITIVETPA                                       LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:        9     10     11     12     13     14     15     16     17     18     19     20     21     22     23     24
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0361        361            20     20     20     20     20     20      R
0362        362            17     20     20     20     20     20     20     20     20     20     20     20     20     20     20
0363        363     20     20     20     20     20     20     20     20     20      R
0364        364     20     20     20     20     20     20     20     20     20             R
0366        366                   20     20     20     20     20     20     20     20     20     20     20     20     20     15
0367        367                                        20     20     18             R
0368        368            15     20     20     20     20     20     20     20     20     20     20     20     20     20     20
0369        369                          20     20     20     20     20     20     20     20     20     20     21     21     20
0370        370      7      7     15     20     20     20     20     20     20     20     20     20     20     20     20     20
0371        371     20     20     20     20     20     20     20     20     20     20     20     20     20     20     20     20
0372        372     10     13     15     20     20     20     20     20     20     20     20     20     20     20     20     20
0373        373            20     20     20     20     20     20     20     20     20     20     20     20     20     20     20
0374        374      7     15     20     20     20     20     20     20     20     20     20     20     20     20     20     20
0375        375                                 20     20     20     20     20     20     17     20     15     14     16     14

SURVIVORS           15     15     15     15     15     15     15     14     14     12     11     11     11     11     11     11
NO. W/TUMORS         6     10     11     12     13     14     14     13     12     10     10     10     10     10     10     10
TOTAL TUMORS        84    167    210    240    260    280    280    258    240    200    197    200    195    195    197    189
MEAN/SURVIVOR      5.6   11.1   14.0   16.0   17.3   18.7   18.7   18.4   17.1   16.7   17.9   18.2   17.7   17.7   17.9   17.2
MEAN W/TUMORS     14.0   16.7   19.1   20.0   20.0   20.0   20.0   19.8   20.0   20.0   19.7   20.0   19.5   19.5   19.7   18.9

NTP  EXP/TEST: 88133-06                      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                               PAGE: 20
TEST TYPE: SUBCHRON 26-WEEK           ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE                         DATE: 05/13/02
ROUTE: SKIN APPLICATION                                     EISRPT43                                              TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI                           TRT#:   13                                            FIRST DOSE: 07/20/98
           SEX: MALE                                       TRT: POSITIVETPA                                       LAST OBS: 01/25/99
------------------------------------------------------------------------------------------------------------------------------------

WEEK-ON-DOSE:       25     26     27     28
------------------------------------------------------------------------------------------------------------------------------------

CAGE     ANIMAL

0361        361
0362        362     20     20     20     20
0363        363
0364        364
0366        366     20     13     20     20
0367        367
0368        368     20             R
0369        369     20     20     20     20
0370        370     20     20     20     20
0371        371     20     20     10      9
0372        372     20     20     20     20
0373        373     20     20     20     20
0374        374     20     20      9      5
0375        375      8      7      7      7

SURVIVORS           11     11     10     10
NO. W/TUMORS        10      9      9      9
TOTAL TUMORS       188    160    146    141
MEAN/SURVIVOR     17.1   14.5   14.6   14.1
MEAN W/TUMORS     18.8   17.8   16.2   15.7



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