TDMS Study 88133-06 Pathology Tables
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION TIME: 13:07:47
EIS REPORT 43
FACILITY: Battelle Columbus Laboratory
NTP C#: 88133B
CONTRACT NUMBER: NO1-ES-65406
CAS NUMBER: 15625-89-5
ANIMAL SUPPLIER: TACONIC FARMS
CAGE RANGE: ALL
DATE RANGE: ALL
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 2 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 0 MG/KG LAST OBS:
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THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 3
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 4 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 0.75 MG/KG LAST OBS:
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THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 4
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 6 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 1.5 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 19 20 21 22 23 24 25 26 27 28
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CAGE ANIMAL
0308 308 1 1 1 1 1 1 1 1 1 1
SURVIVORS 12 12 12 12 12 12 12 12 12 12
NO. W/TUMORS 1 1 1 1 1 1 1 1 1 1
TOTAL TUMORS 1 1 1 1 1 1 1 1 1 1
MEAN/SURVIVOR 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
MEAN W/TUMORS 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 5
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 8 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 3 MG/KG LAST OBS:
------------------------------------------------------------------------------------------------------------------------------------
THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 6
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 10 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 6 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 9 10 11 13 14 15 16 17 18 19 20 21 22 23 24 25
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CAGE ANIMAL
0332 332
0333 333 3 2 2
0334 334
0335 335 1 2 2 3 3 3 3 3 5 7 7
0336 336 3 4
0337 337
0339 339 3
0340 340 1 1 1 1 1 2 1 1 1 1 1 1 1
0341 341 3 3
0342 342 1
0345 345 1 1 1 R
SURVIVORS 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 14
NO. W/TUMORS 1 1 1 1 1 2 2 2 2 2 2 2 2 3 5 7
TOTAL TUMORS 1 1 1 1 1 2 3 3 5 4 4 4 4 9 16 21
MEAN/SURVIVOR 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.2 0.3 0.3 0.3 0.3 0.3 0.6 1.1 1.5
MEAN W/TUMORS 1.0 1.0 1.0 1.0 1.0 1.0 1.5 1.5 2.5 2.0 2.0 2.0 2.0 3.0 3.2 3.0
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 7
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 10 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 6 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 26 27 28
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CAGE ANIMAL
0332 332 1
0333 333 2 2 2
0334 334 3
0335 335 7 12 10
0336 336 4 4 4
0337 337 3
0339 339 3 2 3
0340 340 1 1 2
0341 341 3 3 4
0342 342 1 1 2
0345 345
SURVIVORS 14 14 14
NO. W/TUMORS 8 7 9
TOTAL TUMORS 22 25 33
MEAN/SURVIVOR 1.6 1.8 2.4
MEAN W/TUMORS 2.8 3.6 3.7
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 8
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 12 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 12 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
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CAGE ANIMAL
0346 346 7 9 10 9 15 20 20 22 20 20 20 20 20
0347 347 5 7 6 7 7 7 8 9 10 13 11 9
0348 348 1 1 3 3 4 10 10 15 20 20 20 20 20 20 20 20
0349 349 2 3 3 6 8 8 20 20 20 20 20 20 20 20
0350 350 3 5 7 8 11 13 14 20 20 20 24 25 27 25 24 20
0351 351 7 10 10 10 13 10 12 16 20 20
0352 352 3 7 7 10 20 20 20 20 20 20 20 20
0353 353 3 7 9 11 17 R
0354 354 7 7 7 15 15 12 20 20 20 20
0355 355 14 17 15 20 20 20 20 20 20 20
0356 356 8 10 11 20 20 20 20 20 20 20 20 20
0357 357 7 7 10 16 20 20 20 20 20 20 20 20
0358 358 1 1 1 2 1 9 5 13 20 20 20 20 20 20 20 20
0359 359 8 10 15 15 20 20 20 20 20
0360 360 15 17 20 20 20 15 20 20 20 20 20
SURVIVORS 15 15 15 15 15 15 15 15 14 14 14 14 14 14 14 14
NO. W/TUMORS 3 3 4 6 10 11 14 15 14 14 14 14 14 14 14 14
TOTAL TUMORS 5 7 13 26 58 103 136 203 229 247 252 256 269 274 275 269
MEAN/SURVIVOR 0.3 0.5 0.9 1.7 3.9 6.9 9.1 13.5 16.4 17.6 18.0 18.3 19.2 19.6 19.6 19.2
MEAN W/TUMORS 1.7 2.3 3.3 4.3 5.8 9.4 9.7 13.5 16.4 17.6 18.0 18.3 19.2 19.6 19.6 19.2
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 9
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 12 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: 12 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 26 27 28
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CAGE ANIMAL
0346 346 20 20 20
0347 347 20 20 20
0348 348 20 20 20
0349 349 20 20 20
0350 350 26 28 29
0351 351 20 21 20
0352 352 20 20 20
0353 353
0354 354 20 20 20
0355 355 R
0356 356 20 20 20
0357 357 20 20 20
0358 358 20 20 R
0359 359 20 20 20
0360 360 20 20 20
SURVIVORS 14 13 12
NO. W/TUMORS 13 13 12
TOTAL TUMORS 266 269 249
MEAN/SURVIVOR 19.0 20.7 20.8
MEAN W/TUMORS 20.5 20.7 20.8
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 10
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 14 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: POSITIVETPA LAST OBS: 01/25/99
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WEEK-ON-DOSE: 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
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CAGE ANIMAL
0376 376 20 20 20 20 20 20 20 20 20 20 20 R
0377 377 7 7 7 15 20 20 20 20 20 20 20 20 R
0378 378 3 4 6 4 1 1 6 6 5 5 3 3 4 3 6 10
0379 379 20 20 20 20 20 20 20 20 20 20 20 20 20 R
0380 380 3 7 13 7 20 20 20 20 20 13 20 20 15 15 20 15
0381 381 20 20 20 20 20 20 20 20 20 20 20 15 15 20 20
0384 384 5 10 10 12 13 13 20 20 20 15 20 9 4 3 5
0385 385 18 20 20 20 R
0386 386 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
0387 387 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
0388 388 20 20 20 20 20 20 20 20 20 20 20 20
0389 389 20 20 20 20 20 12 12 12 10 10 6 6 4 4
SURVIVORS 14 14 14 14 14 14 14 14 13 13 13 13 11 10 10 10
NO. W/TUMORS 5 9 10 11 12 12 12 11 11 11 11 11 9 8 8 8
TOTAL TUMORS 53 123 156 174 213 214 219 198 197 190 188 193 129 103 113 114
MEAN/SURVIVOR 3.8 8.8 11.1 12.4 15.2 15.3 15.6 14.1 15.2 14.6 14.5 14.8 11.7 10.3 11.3 11.4
MEAN W/TUMORS 10.6 13.7 15.6 15.8 17.8 17.8 18.3 18.0 17.9 17.3 17.1 17.5 14.3 12.9 14.1 14.3
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 11
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 14 FIRST DOSE: 07/20/98
SEX: FEMALE TRT: POSITIVETPA LAST OBS: 01/25/99
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WEEK-ON-DOSE: 25 26 27 28
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CAGE ANIMAL
0376 376
0377 377
0378 378 5 7 11 14
0379 379
0380 380 11 16 15 12
0381 381 20 20 20 20
0384 384 5 13 4 3
0385 385
0386 386 20 20 20 20
0387 387 20 20 20 20
0388 388 20 20 20 20
0389 389 6 4 4 4
SURVIVORS 10 10 10 10
NO. W/TUMORS 8 8 8 8
TOTAL TUMORS 107 120 114 113
MEAN/SURVIVOR 10.7 12.0 11.4 11.3
MEAN W/TUMORS 13.4 15.0 14.3 14.1
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 12
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 1 FIRST DOSE: 07/20/98
SEX: MALE TRT: 0 MG/KG LAST OBS:
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THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 13
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 3 FIRST DOSE: 07/20/98
SEX: MALE TRT: 0.75 MG/KG LAST OBS:
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THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 14
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 5 FIRST DOSE: 07/20/98
SEX: MALE TRT: 1.5 MG/KG LAST OBS:
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THERE WERE NO PAPILLOMA OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 15
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 7 FIRST DOSE: 07/20/98
SEX: MALE TRT: 3 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 23 28
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CAGE ANIMAL
0229 229 1
0232 232 1
SURVIVORS 14 14
NO. W/TUMORS 1 1
TOTAL TUMORS 1 1
MEAN/SURVIVOR 0.1 0.1
MEAN W/TUMORS 1.0 1.0
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 16
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 9 FIRST DOSE: 07/20/98
SEX: MALE TRT: 6 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
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CAGE ANIMAL
0241 241 2 2 2 2 3 3 4 4 4 4 4 3
0243 243 9 11 8 13 12 13 13 20 R
0245 245 2 1 2 2 2 2 2
0246 246 1 3 3 3
0247 247 1 2 2 3 3 6 6
0248 248 1 1 1 1 1 1 1 2 2 8 8 8 8 13 12
0249 249 6 5 6 7 6 6
0250 250 1 1 1 2 3 4 6 7 8 8
0251 251 2 2 2 3 5 4
0252 252 4 5 9 7 9 15 15 20 20
0254 254 7 6 6 6 8 14 16 20 16 20 20 20 20
0255 255 4 4 6 8
SURVIVORS 15 14 14 14 14 14 14 14 14 14 14 14 14 13 13
NO. W/TUMORS 1 1 2 4 3 6 7 7 8 10 10 11 11 10 10
TOTAL TUMORS 1 1 8 10 9 21 28 35 48 66 65 83 94 91 90
MEAN/SURVIVOR 0.1 0.1 0.6 0.7 0.6 1.5 2.0 2.5 3.4 4.7 4.6 5.9 6.7 7.0 6.9
MEAN W/TUMORS 1.0 1.0 4.0 2.5 3.0 3.5 4.0 5.0 6.0 6.6 6.5 7.5 8.5 9.1 9.0
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 17
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 11 FIRST DOSE: 07/20/98
SEX: MALE TRT: 12 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
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CAGE ANIMAL
0256 256 5 9 12 14 20 20 20 20 20 20 20 20
0258 258 1 1 3 3 6 12 10 15 20 15 20 R
0259 259 7 12 15 16 18 15 20 20 20 20
0260 260 3 2 3 3 8 8 11 10 13 13 17 20 20 20 20 20
0261 261 16 20 20 20 20 20 20 20 20
0262 262 5 6 9 9 13 15 14 20 20 20 20 20
0263 263 1 1 1 1 3 3 5 7 15 20 20 22 20 20 22
0265 265 1 2 3 5 5 5 6 7 6 4 7 13 20
0266 266 3 2 7 7 6 11 12 13 20 20 20 20 20 20 R
0267 267 5 10 14 20 20 20 20 20 20 20
0268 268 7 12 13 17 20 20 20 20 20 20 21
0269 269 4 3 4 5 4 12 11 15 20 20 20 20 20 20 20
0270 270 5 6 8 12 10 12 13 16 20 20 23 23 22
SURVIVORS 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 13
NO. W/TUMORS 1 4 4 6 9 10 12 13 13 13 13 13 13 13 13 11
TOTAL TUMORS 3 10 9 21 40 55 102 130 170 210 222 236 246 245 256 225
MEAN/SURVIVOR 0.2 0.7 0.6 1.4 2.7 3.7 6.8 8.7 11.3 14.0 14.8 15.7 16.4 16.3 17.1 17.3
MEAN W/TUMORS 3.0 2.5 2.3 3.5 4.4 5.5 8.5 10.0 13.1 16.2 17.1 18.2 18.9 18.8 19.7 20.5
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 18
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 11 FIRST DOSE: 07/20/98
SEX: MALE TRT: 12 MG/KG LAST OBS: 01/25/99
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WEEK-ON-DOSE: 25 26 27 28
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CAGE ANIMAL
0256 256 20 20 20 20
0258 258
0259 259 20 20 20 20
0260 260 20 20 20 20
0261 261 20 20 20 20
0262 262 20 20 20 20
0263 263 20 21 23 25
0265 265 20 20 20 20
0266 266
0267 267 20 20 20 20
0268 268 21 21 21 21
0269 269 20 20 R
0270 270 22 28 25 29
SURVIVORS 13 13 12 12
NO. W/TUMORS 11 11 10 10
TOTAL TUMORS 223 230 209 215
MEAN/SURVIVOR 17.2 17.7 17.4 17.9
MEAN W/TUMORS 20.3 20.9 20.9 21.5
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 19
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
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SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 13 FIRST DOSE: 07/20/98
SEX: MALE TRT: POSITIVETPA LAST OBS: 01/25/99
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WEEK-ON-DOSE: 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
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CAGE ANIMAL
0361 361 20 20 20 20 20 20 R
0362 362 17 20 20 20 20 20 20 20 20 20 20 20 20 20 20
0363 363 20 20 20 20 20 20 20 20 20 R
0364 364 20 20 20 20 20 20 20 20 20 R
0366 366 20 20 20 20 20 20 20 20 20 20 20 20 20 15
0367 367 20 20 18 R
0368 368 15 20 20 20 20 20 20 20 20 20 20 20 20 20 20
0369 369 20 20 20 20 20 20 20 20 20 20 21 21 20
0370 370 7 7 15 20 20 20 20 20 20 20 20 20 20 20 20 20
0371 371 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
0372 372 10 13 15 20 20 20 20 20 20 20 20 20 20 20 20 20
0373 373 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
0374 374 7 15 20 20 20 20 20 20 20 20 20 20 20 20 20 20
0375 375 20 20 20 20 20 20 17 20 15 14 16 14
SURVIVORS 15 15 15 15 15 15 15 14 14 12 11 11 11 11 11 11
NO. W/TUMORS 6 10 11 12 13 14 14 13 12 10 10 10 10 10 10 10
TOTAL TUMORS 84 167 210 240 260 280 280 258 240 200 197 200 195 195 197 189
MEAN/SURVIVOR 5.6 11.1 14.0 16.0 17.3 18.7 18.7 18.4 17.1 16.7 17.9 18.2 17.7 17.7 17.9 17.2
MEAN W/TUMORS 14.0 16.7 19.1 20.0 20.0 20.0 20.0 19.8 20.0 20.0 19.7 20.0 19.5 19.5 19.7 18.9
NTP EXP/TEST: 88133-06 TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA) PAGE: 20
TEST TYPE: SUBCHRON 26-WEEK ANIMALS WITH SKIN PAPILLOMAS AT SOA BY WEEK-ON-DOSE DATE: 05/13/02
ROUTE: SKIN APPLICATION EISRPT43 TIME: 13:07:47
------------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: MICE-TG.AC HEMI TRT#: 13 FIRST DOSE: 07/20/98
SEX: MALE TRT: POSITIVETPA LAST OBS: 01/25/99
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WEEK-ON-DOSE: 25 26 27 28
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CAGE ANIMAL
0361 361
0362 362 20 20 20 20
0363 363
0364 364
0366 366 20 13 20 20
0367 367
0368 368 20 R
0369 369 20 20 20 20
0370 370 20 20 20 20
0371 371 20 20 10 9
0372 372 20 20 20 20
0373 373 20 20 20 20
0374 374 20 20 9 5
0375 375 8 7 7 7
SURVIVORS 11 11 10 10
NO. W/TUMORS 10 9 9 9
TOTAL TUMORS 188 160 146 141
MEAN/SURVIVOR 17.1 14.5 14.6 14.1
MEAN W/TUMORS 18.8 17.8 16.2 15.7
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