National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4969

TDMS Study 88133-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                           TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        DATE: 07/12/02       
EXPERIMENT: 88133 TEST: 06                                                                                     TIME: 08:52:59       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                   PAGE:       1        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88133B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 15625-89-5      
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                                                              Final#2                                                               
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 MG/KG                                                                       
                                       INCLUDE 002    0 MG/KG                                                                       
                                       INCLUDE 003    0.75    MG/KG                                                                 
                                       INCLUDE 004    0.75    MG/KG                                                                 
                                       INCLUDE 005    1.5     MG/KG                                                                 
                                       INCLUDE 006    1.5     MG/KG                                                                 
                                       INCLUDE 007    3 MG/KG                                                                       
                                       INCLUDE 008    3 MG/KG                                                                       
                                       INCLUDE 009    6 MG/KG                                                                       
                                       INCLUDE 010    6 MG/KG                                                                       
                                       INCLUDE 011    12 MG/KG                                                                      
                                       INCLUDE 012    12 MG/KG                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                           TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        DATE: 07/12/02       
EXPERIMENT: 88133 TEST: 06                                                                                     TIME: 08:52:59       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                                        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88133B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 15625-89-5      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                                                                      
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Epididymis                             Inflammation Chronic                                                                         
Epididymis: Unilateral                 Hypospermia                                                                                  
Kidney                                 Inflammation Chronic                                                                         
Liver                                  Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular                                                                        
Lymph Node                             Hyperplasia                                                                                  
                                       Inflammation Chronic                                                                         
Lymph Node, Mandibular                 Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular                                                                        
Lymph Node: Mediastinal                Infiltration Cellular                                                                        
                                       Infiltration Cellular Plasma Cell                                                            
                                       Inflammation Chronic                                                                         
Skin: Epidermis, Skin, Site of Application                                                                                          
                                       Hyperplasia                                                                                  
Skin: Skin, Site of Application        Hyperkeratosis                                                                               
                                       Inflammation Chronic                                                                         
Spleen                                 Atrophy                                                                                      
                                       Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Hyperkeratosis                                                                               
Testes: Unilateral, Germinal Epithelium                                                                                             
                                       Degeneration                                                                                 
Thymus                                 Atrophy                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Kidney                                 Inflammation Chronic                                                                         
                                       Nephropathy                                                                                  
Liver                                  Hematopoietic Cell Proliferation                                                             
                                       Inflammation Chronic                                                                         
                                       Myelodysplasia                                                                               
                                       Pigmentation                                                                                 
Lymph Node                             Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia                                                                                  
Lymph Node, Mandibular                 Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular Plasma Cell                                                            
Lymph Node, Mesenteric                 Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular                                                                        
Lymph Node: Inguinal                   Infiltration Cellular Plasma Cell                                                            
                                       Myelodysplasia                                                                               
Lymph Node: Mediastinal                Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular                                                                        
                                       Infiltration Cellular Plasma Cell                                                            
Skin: Epidermis, Skin, Site of Application                                                                                          
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                           TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        DATE: 07/12/02       
EXPERIMENT: 88133 TEST: 06                                                                                     TIME: 08:52:59       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                                        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88133B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 15625-89-5      
                                       Hyperplasia                                                                                  
                                       Hyperplasia Focal                                                                            
Skin: Skin, Site of Application        Hyperkeratosis                                                                               
                                       Inflammation Chronic                                                                         
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Myelodysplasia                                                                               
Thyroid Gland                          Inflammation Chronic                                                                         
===============================================================                                                                     
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE
 (TMPTA)                                                                                                                            
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/15 (47%)       5/15 (33%)       9/15 (60%)       8/15 (53%)       5/15 (33%)       5/15 (33%)      | 
|POLY-3 RATE (b)    |        7/14.15          5/15.00          9/12.73          8/14.33          5/13.93          5/14.43         | 
|POLY-3 PERCENT (g) |        49.5%            33.3%            70.7%            55.9%            35.9%            34.7%           | 
|TERMINAL (d)       |        7/14 (50%)       5/15 (33%)       9/12 (75%)       8/14 (57%)       5/13 (39%)       4/11 (36%)      | 
|FIRST INCIDENCE    |        192 (T)          192 (T)          192 (T)          192 (T)          192 (T)          161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.390N         P=0.300N         P=0.188          P=0.500          P=0.416N         P=0.542N        | 
|POLY 3             |        P=0.186N         P=0.309N         P=0.234          P=0.514          P=0.367N         P=0.339N        | 
|POLY 1.5           |        P=0.182N         P=0.322N         P=0.267          P=0.514          P=0.363N         P=0.339N        | 
|POLY 6             |        P=0.201N         P=0.302N         P=0.209          P=0.507          P=0.374N         P=0.353N        | 
|LOGISTIC REGRESSION|        P=0.213N         P=0.300N         P=0.188          P=0.500          P=0.416N         P=0.356N        | 
|COCH-ARM / FISHERS |        P=0.192N         P=0.355N         P=0.358          P=0.500          P=0.355N         P=0.355N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          0/12.32          0/14.27          0/14.59          0/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        0/12 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        2/15 (13%)       0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/14.15          2/15.00          0/12.73          0/14.33          0/13.93          3/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             13.3%            0.0%             0.0%             0.0%             21.4%           | 
|TERMINAL (d)       |        0/14 (0%)        2/15 (13%)       0/12 (0%)        0/14 (0%)        0/13 (0%)        3/11 (27%)      | 
|FIRST INCIDENCE    |        ---              192 (T)          ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.025 *        P=0.251          (e)              (e)              (e)              P=0.076         | 
|POLY 3             |        P=0.044 *        P=0.245          (e)              (e)              (e)              P=0.103         | 
|POLY 1.5           |        P=0.043 *        P=0.241          (e)              (e)              (e)              P=0.106         | 
|POLY 6             |        P=0.043 *        P=0.247          (e)              (e)              (e)              P=0.096         | 
|LOGISTIC REGRESSION|        (e)              P=0.251          (e)              (e)              (e)              P=0.076         | 
|COCH-ARM / FISHERS |        P=0.045 *        P=0.241          (e)              (e)              (e)              P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis: Unilateral                                                                                                           | 
|     Hypospermia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/15 (27%)       0/15 (0%)        2/15 (13%)       1/15 (7%)        1/15 (7%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        4/14.15          0/15.00          2/13.18          1/14.33          1/13.93          2/14.02         | 
|POLY-3 PERCENT (g) |        28.3%            0.0%             15.2%            7.0%             7.2%             14.3%           | 
|TERMINAL (d)       |        4/14 (29%)       0/15 (0%)        1/12 (8%)        1/14 (7%)        1/13 (8%)        2/11 (18%)      | 
|FIRST INCIDENCE    |        192 (T)          ---              157              192 (T)          192 (T)          192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.599          P=0.048N*        P=0.400N         P=0.166N         P=0.189N         P=0.449N        | 
|POLY 3             |        P=0.529N         P=0.038N*        P=0.361N         P=0.157N         P=0.166N         P=0.330N        | 
|POLY 1.5           |        P=0.520N         P=0.040N*        P=0.354N         P=0.157N         P=0.164N         P=0.324N        | 
|POLY 6             |        P=0.541N         P=0.037N*        P=0.363N         P=0.159N         P=0.168N         P=0.348N        | 
|LOGISTIC REGRESSION|        P=0.508N         (e)              P=0.353N         P=0.166N         P=0.189N         P=0.449N        | 
|COCH-ARM / FISHERS |        P=0.508N         P=0.050N         P=0.326N         P=0.165N         P=0.165N         P=0.326N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis: Unilateral                                                                                                           | 
|     Hypospermia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        2/15 (13%)       1/15 (7%)        0/15 (0%)        1/15 (7%)        5/15 (33%)      | 
|POLY-3 RATE (b)    |        0/14.15          2/15.00          1/12.73          0/14.33          1/13.93          5/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             13.3%            7.9%             0.0%             7.2%             35.7%           | 
|TERMINAL (d)       |        0/14 (0%)        2/15 (13%)       1/12 (8%)        0/14 (0%)        1/13 (8%)        5/11 (46%)      | 
|FIRST INCIDENCE    |        ---              192 (T)          192 (T)          ---              192 (T)          192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.251          P=0.469          (e)              P=0.485          P=0.012 *       | 
|POLY 3             |        P=0.003 **       P=0.245          P=0.479          (e)              P=0.497          P=0.016 *       | 
|POLY 1.5           |        P=0.003 **       P=0.241          P=0.485          (e)              P=0.498          P=0.017 *       | 
|POLY 6             |        P=0.002 **       P=0.247          P=0.474          (e)              P=0.495          P=0.013 *       | 
|LOGISTIC REGRESSION|        (e)              P=0.251          P=0.469          (e)              P=0.485          P=0.012 *       | 
|COCH-ARM / FISHERS |        P=0.004 **       P=0.241          P=0.500          (e)              P=0.500          P=0.021 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        2/15 (13%)       0/15 (0%)        0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          2/12.32          0/14.27          0/14.59          3/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             16.2%            0.0%             0.0%             21.5%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        2/12 (17%)       0/14 (0%)        0/14 (0%)        3/12 (25%)      | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.022 *        (e)              P=0.188          (e)              (e)              P=0.079         | 
|POLY 3             |        P=0.022 *        (e)              P=0.188          (e)              (e)              P=0.092         | 
|POLY 1.5           |        P=0.024 *        (e)              P=0.197          (e)              (e)              P=0.097         | 
|POLY 6             |        P=0.021 *        (e)              P=0.184          (e)              (e)              P=0.087         | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.188          (e)              (e)              P=0.079         | 
|COCH-ARM / FISHERS |        P=0.032 *        (e)              P=0.241          (e)              (e)              P=0.112         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/15 (20%)       6/15 (40%)       0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        3/14.15          6/15.00          0/12.73          0/14.33          0/13.93          3/14.02         | 
|POLY-3 PERCENT (g) |        21.2%            40.0%            0.0%             0.0%             0.0%             21.4%           | 
|TERMINAL (d)       |        3/14 (21%)       6/15 (40%)       0/12 (0%)        0/14 (0%)        0/13 (0%)        3/11 (27%)      | 
|FIRST INCIDENCE    |        192 (T)          192 (T)          ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.525N         P=0.252          P=0.143N         P=0.115N         P=0.128N         P=0.551         | 
|POLY 3             |        P=0.371N         P=0.246          P=0.125N         P=0.103N         P=0.108N         P=0.668         | 
|POLY 1.5           |        P=0.379N         P=0.237          P=0.119N         P=0.103N         P=0.107N         P=0.669N        | 
|POLY 6             |        P=0.369N         P=0.251          P=0.130N         P=0.104N         P=0.109N         P=0.650         | 
|LOGISTIC REGRESSION|        P=0.525N         P=0.252          (e)              (e)              (e)              P=0.551         | 
|COCH-ARM / FISHERS |        P=0.411N         P=0.213          P=0.112N         P=0.112N         P=0.112N         P=0.674N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/15 (27%)       0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        4/15.00          0/14.85          0/12.32          0/14.27          0/14.59          1/13.93         | 
|POLY-3 PERCENT (g) |        26.7%            0.0%             0.0%             0.0%             0.0%             7.2%            | 
|TERMINAL (d)       |        4/15 (27%)       0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        1/12 (8%)       | 
|FIRST INCIDENCE    |        193 (T)          ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.347N         P=0.065N         P=0.086N         P=0.065N         P=0.065N         P=0.240N        | 
|POLY 3             |        P=0.267N         P=0.046N*        P=0.073N         P=0.051N         P=0.048N*        P=0.186N        | 
|POLY 1.5           |        P=0.274N         P=0.046N*        P=0.066N         P=0.049N*        P=0.047N*        P=0.177N        | 
|POLY 6             |        P=0.262N         P=0.047N*        P=0.077N         P=0.053N         P=0.051N         P=0.197N        | 
|LOGISTIC REGRESSION|        P=0.347N         (e)              (e)              (e)              (e)              P=0.240N        | 
|COCH-ARM / FISHERS |        P=0.313N         P=0.050N         P=0.050N         P=0.050N         P=0.050N         P=0.165N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       1/15 (7%)        5/15 (33%)       4/15 (27%)       4/15 (27%)       0/15 (0%)       | 
|POLY-3 RATE (b)    |        2/14.15          1/15.00          5/12.73          4/14.33          4/13.93          0/14.02         | 
|POLY-3 PERCENT (g) |        14.1%            6.7%             39.3%            27.9%            28.7%            0.0%            | 
|TERMINAL (d)       |        2/14 (14%)       1/15 (7%)        5/12 (42%)       4/14 (29%)       4/13 (31%)       0/11 (0%)       | 
|FIRST INCIDENCE    |        192 (T)          192 (T)          192 (T)          192 (T)          192 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.245N         P=0.475N         P=0.135          P=0.326          P=0.289          P=0.290N        | 
|POLY 3             |        P=0.174N         P=0.479N         P=0.147          P=0.332          P=0.318          P=0.233N        | 
|POLY 1.5           |        P=0.163N         P=0.485N         P=0.160          P=0.333          P=0.321          P=0.230N        | 
|POLY 6             |        P=0.196N         P=0.476N         P=0.138          P=0.329          P=0.314          P=0.241N        | 
|LOGISTIC REGRESSION|        P=0.245N         P=0.475N         P=0.135          P=0.326          P=0.289          (e)             | 
|COCH-ARM / FISHERS |        P=0.162N         P=0.500N         P=0.195          P=0.326          P=0.326          P=0.241N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/15.00          1/14.85          0/12.32          0/14.27          2/14.59          1/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             0.0%             0.0%             13.7%            7.2%            | 
|TERMINAL (d)       |        0/15 (0%)        1/14 (7%)        0/12 (0%)        0/14 (0%)        2/14 (14%)       1/12 (8%)       | 
|FIRST INCIDENCE    |        ---              193 (T)          ---              ---              193 (T)          193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.186          P=0.486          (e)              (e)              P=0.221          P=0.455         | 
|POLY 3             |        P=0.212          P=0.498          (e)              (e)              P=0.225          P=0.485         | 
|POLY 1.5           |        P=0.218          P=0.499          (e)              (e)              P=0.228          P=0.491         | 
|POLY 6             |        P=0.204          P=0.496          (e)              (e)              P=0.221          P=0.479         | 
|LOGISTIC REGRESSION|        (e)              P=0.486          (e)              (e)              P=0.221          P=0.455         | 
|COCH-ARM / FISHERS |        P=0.219          P=0.500          (e)              (e)              P=0.241          P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        6/15 (40%)      | 
|POLY-3 RATE (b)    |        1/15.00          0/15.00          1/12.73          0/14.33          0/13.93          6/14.02         | 
|POLY-3 PERCENT (g) |        6.7%             0.0%             7.9%             0.0%             0.0%             42.8%           | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        1/12 (8%)        0/14 (0%)        0/13 (0%)        6/11 (55%)      | 
|FIRST INCIDENCE    |        101              ---              192 (T)          ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.500N         P=0.727          P=0.500N         P=0.514N         P=0.024 *       | 
|POLY 3             |        P<0.001 **       P=0.500N         P=0.723          P=0.509N         P=0.515N         P=0.025 *       | 
|POLY 1.5           |        P<0.001 **       P=0.500N         P=0.734          P=0.506N         P=0.510N         P=0.029 *       | 
|POLY 6             |        P<0.001 **       P=0.500N         P=0.715          P=0.512N         P=0.518N         P=0.020 *       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.691N         (e)              P=0.421N         P=0.032 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.759N         P=0.500N         P=0.500N         P=0.040 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        6/15 (40%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          0/14.27          0/14.59          6/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             0.0%             0.0%             43.1%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        0/14 (0%)        0/14 (0%)        6/12 (50%)      | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.455          (e)              (e)              P=0.005 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.461          (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.470          (e)              (e)              P=0.004 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.457          (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.455          (e)              (e)              P=0.005 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          (e)              (e)              P=0.008 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        5/15 (33%)      | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          0/12.73          0/14.33          0/13.93          5/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             35.7%           | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        5/11 (46%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.012 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.017 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.013 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.012 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.021 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          0/14.27          0/14.59          1/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             0.0%             0.0%             7.2%            | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        0/14 (0%)        0/14 (0%)        1/12 (8%)       | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.289          (e)              P=0.455          (e)              (e)              P=0.455         | 
|POLY 3             |        P=0.294          (e)              P=0.461          (e)              (e)              P=0.485         | 
|POLY 1.5           |        P=0.301          (e)              P=0.470          (e)              (e)              P=0.491         | 
|POLY 6             |        P=0.288          (e)              P=0.457          (e)              (e)              P=0.479         | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.455          (e)              (e)              P=0.455         | 
|COCH-ARM / FISHERS |        P=0.316          (e)              P=0.500          (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/15 (47%)       10/15 (67%)      8/15 (53%)       8/15 (53%)       7/15 (47%)       8/15 (53%)      | 
|POLY-3 RATE (b)    |        7/14.15          10/15.00         8/13.60          8/14.33          7/13.93          8/14.02         | 
|POLY-3 PERCENT (g) |        49.5%            66.7%            58.8%            55.9%            50.2%            57.1%           | 
|TERMINAL (d)       |        7/14 (50%)       10/15 (67%)      7/12 (58%)       8/14 (57%)       7/13 (54%)       8/11 (73%)      | 
|FIRST INCIDENCE    |        192 (T)          192 (T)          95               192 (T)          192 (T)          192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.340          P=0.300          P=0.344          P=0.500          P=0.572          P=0.234         | 
|POLY 3             |        P=0.499N         P=0.290          P=0.457          P=0.514          P=0.629          P=0.490         | 
|POLY 1.5           |        P=0.476N         P=0.272          P=0.469          P=0.514          P=0.633          P=0.505         | 
|POLY 6             |        P=0.547N         P=0.299          P=0.441          P=0.507          P=0.621          P=0.448         | 
|LOGISTIC REGRESSION|        P=0.469N         P=0.300          P=0.440          P=0.500          P=0.572          P=0.234         | 
|COCH-ARM / FISHERS |        P=0.469N         P=0.231          P=0.500          P=0.500          P=0.642N         P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        15/15 (100%)     14/15 (93%)      13/15 (87%)      13/15 (87%)      14/15 (93%)      8/15 (53%)      | 
|POLY-3 RATE (b)    |        15/15.00         14/15.00         13/13.07         13/14.27         14/14.59         8/13.93         | 
|POLY-3 PERCENT (g) |        100.0%           93.3%            99.5%            91.1%            96.0%            57.5%           | 
|TERMINAL (d)       |        15/15 (100%)     13/14 (93%)      12/12 (100%)     13/14 (93%)      14/14 (100%)     8/12 (67%)      | 
|FIRST INCIDENCE    |        193 (T)          183              122              193 (T)          193 (T)          193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002N**       P=0.753N         P=0.471          P=0.486N         P=1.000N         P=0.033N*       | 
|POLY 3             |        P<0.001N**       P=0.500N         P=1.000N         P=0.386N         P=0.748N         P=0.003N**      | 
|POLY 1.5           |        P<0.001N**       P=0.500N         P=0.988N         P=0.312N         P=0.614N         P=0.002N**      | 
|POLY 6             |        P<0.001N**       P=0.500N         P=1.000N         P=0.458N         P=0.964N         P=0.004N**      | 
|LOGISTIC REGRESSION|        P<0.001N**       (e)              (e)              P=0.486N         P=1.000N         P=0.033N*       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500N         P=0.241N         P=0.241N         P=0.500N         P=0.003N**      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          0/12.73          0/14.33          0/13.93          1/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             7.1%            | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        1/11 (9%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.082          (e)              (e)              (e)              (e)              P=0.452         | 
|POLY 3             |        P=0.106          (e)              (e)              (e)              (e)              P=0.498         | 
|POLY 1.5           |        P=0.107          (e)              (e)              (e)              (e)              P=0.501         | 
|POLY 6             |        P=0.103          (e)              (e)              (e)              (e)              P=0.491         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.452         | 
|COCH-ARM / FISHERS |        P=0.105          (e)              (e)              (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          0/12.32          0/14.27          0/14.59          2/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.4%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        2/12 (17%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.188         | 
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.214         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.221         | 
|POLY 6             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.208         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.188         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        2/15 (13%)       0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/14.15          2/15.00          0/12.73          0/14.33          0/13.93          0/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             13.3%            0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/14 (0%)        2/15 (13%)       0/12 (0%)        0/14 (0%)        0/13 (0%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              192 (T)          ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.317N         P=0.251          (e)              (e)              (e)              (e)             | 
|POLY 3             |        P=0.260N         P=0.245          (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.266N         P=0.241          (e)              (e)              (e)              (e)             | 
|POLY 6             |        P=0.256N         P=0.247          (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.251          (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.286N         P=0.241          (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        12/15 (80%)      15/15 (100%)     12/15 (80%)      13/15 (87%)      14/15 (93%)      4/15 (27%)      | 
|POLY-3 RATE (b)    |        12/15.00         15/15.00         12/12.32         13/14.27         14/15.00         4/13.93         | 
|POLY-3 PERCENT (g) |        80.0%            100.0%           97.4%            91.1%            93.3%            28.7%           | 
|TERMINAL (d)       |        12/15 (80%)      14/14 (100%)     12/12 (100%)     13/14 (93%)      13/14 (93%)      4/12 (33%)      | 
|FIRST INCIDENCE    |        193 (T)          183              193 (T)          193 (T)          162              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.068          P=0.157          P=0.324          P=0.192          P=0.022N*       | 
|POLY 3             |        P<0.001N**       P=0.106          P=0.207          P=0.371          P=0.298          P=0.003N**      | 
|POLY 1.5           |        P<0.001N**       P=0.106          P=0.317          P=0.417          P=0.298          P=0.003N**      | 
|POLY 6             |        P<0.001N**       P=0.106          P=0.163          P=0.336          P=0.298          P=0.005N**      | 
|LOGISTIC REGRESSION|        P<0.001N**       (e)              P=0.157          P=0.324          (e)              P=0.022N*       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.112          P=0.674N         P=0.500          P=0.299          P=0.005N**      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       2/15 (13%)       2/15 (13%)       0/15 (0%)        1/15 (7%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        2/15.00          2/15.00          2/12.73          0/14.33          1/13.93          1/14.02         | 
|POLY-3 PERCENT (g) |        13.3%            13.3%            15.7%            0.0%             7.2%             7.1%            | 
|TERMINAL (d)       |        1/14 (7%)        2/15 (13%)       2/12 (17%)       0/14 (0%)        1/13 (8%)        1/11 (9%)       | 
|FIRST INCIDENCE    |        101              192 (T)          192 (T)          ---              192 (T)          192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.379N         P=0.678N         P=0.641          P=0.240N         P=0.525N         P=0.556N        | 
|POLY 3             |        P=0.325N         P=0.698          P=0.637          P=0.242N         P=0.526N         P=0.524N        | 
|POLY 1.5           |        P=0.319N         P=0.698          P=0.655          P=0.238N         P=0.518N         P=0.513N        | 
|POLY 6             |        P=0.334N         P=0.698          P=0.624          P=0.246N         P=0.532N         P=0.540N        | 
|LOGISTIC REGRESSION|        P=0.317N         P=0.678N         P=0.662N         P=0.284N         P=0.479N         P=0.612N        | 
|COCH-ARM / FISHERS |        P=0.310N         P=0.701N         P=0.701N         P=0.241N         P=0.500N         P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/15 (27%)       2/15 (13%)       1/15 (7%)        2/15 (13%)       1/15 (7%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        4/15.00          2/14.85          1/12.32          2/14.27          1/14.59          1/13.93         | 
|POLY-3 PERCENT (g) |        26.7%            13.5%            8.1%             14.0%            6.9%             7.2%            | 
|TERMINAL (d)       |        4/15 (27%)       2/14 (14%)       1/12 (8%)        2/14 (14%)       1/14 (7%)        1/12 (8%)       | 
|FIRST INCIDENCE    |        193 (T)          193 (T)          193 (T)          193 (T)          193 (T)          193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.198N         P=0.360N         P=0.240N         P=0.360N         P=0.189N         P=0.240N        | 
|POLY 3             |        P=0.155N         P=0.332N         P=0.230N         P=0.352N         P=0.171N         P=0.186N        | 
|POLY 1.5           |        P=0.154N         P=0.330N         P=0.214N         P=0.343N         P=0.168N         P=0.177N        | 
|POLY 6             |        P=0.159N         P=0.336N         P=0.238N         P=0.359N         P=0.177N         P=0.197N        | 
|LOGISTIC REGRESSION|        P=0.198N         P=0.360N         P=0.240N         P=0.360N         P=0.189N         P=0.240N        | 
|COCH-ARM / FISHERS |        P=0.162N         P=0.326N         P=0.165N         P=0.326N         P=0.165N         P=0.165N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        2/15 (13%)       0/15 (0%)        0/15 (0%)        0/15 (0%)        2/14 (14%)      | 
|POLY-3 RATE (b)    |        0/14.15          2/15.00          0/12.73          0/14.33          0/13.93          2/13.02         | 
|POLY-3 PERCENT (g) |        0.0%             13.3%            0.0%             0.0%             0.0%             15.4%           | 
|TERMINAL (d)       |        0/14 (0%)        2/15 (13%)       0/12 (0%)        0/14 (0%)        0/13 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              192 (T)          ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.123          P=0.251          (e)              (e)              (e)              P=0.164         | 
|POLY 3             |        P=0.183          P=0.245          (e)              (e)              (e)              P=0.211         | 
|POLY 1.5           |        P=0.181          P=0.241          (e)              (e)              (e)              P=0.215         | 
|POLY 6             |        P=0.181          P=0.247          (e)              (e)              (e)              P=0.202         | 
|LOGISTIC REGRESSION|        (e)              P=0.251          (e)              (e)              (e)              P=0.164         | 
|COCH-ARM / FISHERS |        P=0.176          P=0.241          (e)              (e)              (e)              P=0.224         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          0/14.27          0/14.59          0/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        0/14 (0%)        0/14 (0%)        0/12 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.581N         (e)              P=0.455          (e)              (e)              (e)             | 
|POLY 3             |        P=0.585N         (e)              P=0.461          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.581N         (e)              P=0.470          (e)              (e)              (e)             | 
|POLY 6             |        P=0.587N         (e)              P=0.457          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.455          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.561N         (e)              P=0.500          (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        0/14 (0%)       | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          0/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        2/12 (17%)      | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          2/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             18.3%           | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.190         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.226         | 
|POLY 1.5           |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.235         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.217         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.190         | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.261         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        4/14 (29%)      | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          4/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             30.4%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        4/11 (36%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.044 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.051         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.053         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.047 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.044 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.057         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        2/12 (17%)      | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          2/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             18.3%           | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.190         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.226         | 
|POLY 1.5           |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.235         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.217         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.190         | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.261         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        3/14 (21%)      | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          3/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             22.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        3/11 (27%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.098         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.118         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.120         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.112         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.098         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.124         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        0/12 (0%)       | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          0/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        2/13 (15%)      | 
|POLY-3 RATE (b)    |        0/14.15          0/14.00          0/12.73          0/14.33          0/13.82          2/12.03         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             16.6%           | 
|TERMINAL (d)       |        0/14 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.005 **       (e)              (e)              (e)              (e)              P=0.164         | 
|POLY 3             |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.193         | 
|POLY 1.5           |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.197         | 
|POLY 6             |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.184         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.164         | 
|COCH-ARM / FISHERS |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.206         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        6/15 (40%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          0/14.27          0/14.59          6/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             0.0%             0.0%             43.1%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        0/14 (0%)        0/14 (0%)        6/12 (50%)      | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.455          (e)              (e)              P=0.005 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.461          (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.470          (e)              (e)              P=0.004 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.457          (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.455          (e)              (e)              P=0.005 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          (e)              (e)              P=0.008 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/14 (7%)        1/15 (7%)        0/15 (0%)        1/14 (7%)        1/13 (8%)       | 
|POLY-3 RATE (b)    |        0/14.15          1/14.00          1/13.18          0/14.33          1/14.00          1/12.03         | 
|POLY-3 PERCENT (g) |        0.0%             7.1%             7.6%             0.0%             7.1%             8.3%            | 
|TERMINAL (d)       |        0/14 (0%)        1/14 (7%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              192 (T)          157              ---              180              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.376          P=0.500          P=0.485          (e)              P=0.500          P=0.433         | 
|POLY 3             |        P=0.371          P=0.498          P=0.486          (e)              P=0.498          P=0.468         | 
|POLY 1.5           |        P=0.378          P=0.495          P=0.489          (e)              P=0.495          P=0.471         | 
|POLY 6             |        P=0.356          P=0.500          P=0.485          (e)              P=0.500          P=0.459         | 
|LOGISTIC REGRESSION|        P=0.359          P=0.500          P=0.557          (e)              P=0.448          P=0.433         | 
|COCH-ARM / FISHERS |        P=0.376          P=0.483          P=0.500          (e)              P=0.483          P=0.464         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        3/15 (20%)       3/15 (20%)       0/15 (0%)        3/15 (20%)       3/15 (20%)      | 
|POLY-3 RATE (b)    |        1/15.00          3/14.85          3/13.29          0/14.27          3/15.00          3/13.93         | 
|POLY-3 PERCENT (g) |        6.7%             20.2%            22.6%            0.0%             20.0%            21.5%           | 
|TERMINAL (d)       |        1/15 (7%)        3/14 (21%)       2/12 (17%)       0/14 (0%)        2/14 (14%)       3/12 (25%)      | 
|FIRST INCIDENCE    |        193 (T)          193 (T)          63               ---              162              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.245          P=0.273          P=0.245          P=0.514N         P=0.285          P=0.220         | 
|POLY 3             |        P=0.272          P=0.295          P=0.254          P=0.510N         P=0.298          P=0.270         | 
|POLY 1.5           |        P=0.282          P=0.296          P=0.264          P=0.507N         P=0.298          P=0.281         | 
|POLY 6             |        P=0.261          P=0.291          P=0.248          P=0.513N         P=0.298          P=0.259         | 
|LOGISTIC REGRESSION|        P=0.287          P=0.273          P=0.448          (e)              (e)              P=0.220         | 
|COCH-ARM / FISHERS |        P=0.295          P=0.299          P=0.299          P=0.500N         P=0.299          P=0.299         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        4/13 (31%)      | 
|POLY-3 RATE (b)    |        0/14.15          0/14.00          0/12.73          0/14.33          0/13.82          4/12.03         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             33.3%           | 
|TERMINAL (d)       |        0/14 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        4/10 (40%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.023 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.025 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.027 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.022 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.023 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.035 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          0/14.27          0/14.59          1/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             0.0%             0.0%             7.2%            | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        0/14 (0%)        0/14 (0%)        1/12 (8%)       | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.289          (e)              P=0.455          (e)              (e)              P=0.455         | 
|POLY 3             |        P=0.294          (e)              P=0.461          (e)              (e)              P=0.485         | 
|POLY 1.5           |        P=0.301          (e)              P=0.470          (e)              (e)              P=0.491         | 
|POLY 6             |        P=0.288          (e)              P=0.457          (e)              (e)              P=0.479         | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.455          (e)              (e)              P=0.455         | 
|COCH-ARM / FISHERS |        P=0.316          (e)              P=0.500          (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/14 (0%)        1/13 (8%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/14.00          0/12.73          0/14.33          0/13.82          1/12.03         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             8.3%            | 
|TERMINAL (d)       |        0/14 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.075          (e)              (e)              (e)              (e)              P=0.433         | 
|POLY 3             |        P=0.091          (e)              (e)              (e)              (e)              P=0.468         | 
|POLY 1.5           |        P=0.092          (e)              (e)              (e)              (e)              P=0.471         | 
|POLY 6             |        P=0.088          (e)              (e)              (e)              (e)              P=0.459         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.433         | 
|COCH-ARM / FISHERS |        P=0.091          (e)              (e)              (e)              (e)              P=0.464         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          0/14.27          0/14.59          2/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             0.0%             0.0%             14.4%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        0/14 (0%)        0/14 (0%)        2/12 (17%)      | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.047 *        (e)              P=0.455          (e)              (e)              P=0.188         | 
|POLY 3             |        P=0.053          (e)              P=0.461          (e)              (e)              P=0.214         | 
|POLY 1.5           |        P=0.055          (e)              P=0.470          (e)              (e)              P=0.221         | 
|POLY 6             |        P=0.051          (e)              P=0.457          (e)              (e)              P=0.208         | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.455          (e)              (e)              P=0.188         | 
|COCH-ARM / FISHERS |        P=0.060          (e)              P=0.500          (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        0/12 (0%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/14.00          0/11.73          0/14.33          0/13.93          0/11.44         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/14 (0%)        0/14 (0%)        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        4/15 (27%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.00          0/12.07          0/14.27          0/14.59          4/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             28.7%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        4/12 (33%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.033 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.036 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.039 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.033 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.033 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.050         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        1/12 (8%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/14.00          0/11.73          0/14.33          0/13.93          1/11.44         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             8.7%            | 
|TERMINAL (d)       |        0/14 (0%)        0/14 (0%)        0/11 (0%)        0/14 (0%)        0/13 (0%)        1/10 (10%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.077          (e)              (e)              (e)              (e)              P=0.433         | 
|POLY 3             |        P=0.086          (e)              (e)              (e)              (e)              P=0.457         | 
|POLY 1.5           |        P=0.086          (e)              (e)              (e)              (e)              P=0.458         | 
|POLY 6             |        P=0.085          (e)              (e)              (e)              (e)              P=0.453         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.433         | 
|COCH-ARM / FISHERS |        P=0.085          (e)              (e)              (e)              (e)              P=0.444         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/14 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.00          0/12.07          0/14.27          0/14.59          2/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.4%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        2/12 (17%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.188         | 
|POLY 3             |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.214         | 
|POLY 1.5           |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.221         | 
|POLY 6             |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.208         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.188         | 
|COCH-ARM / FISHERS |        P=0.012 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Inguinal                                                                                                             | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        0/14 (0%)       | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          0/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Inguinal                                                                                                             | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        2/12 (17%)      | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          2/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             18.3%           | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.190         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.226         | 
|POLY 1.5           |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.235         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.217         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.190         | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.261         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Inguinal                                                                                                             | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        0/14 (0%)       | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          0/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Inguinal                                                                                                             | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        2/12 (17%)      | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          2/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             18.3%           | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.190         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.226         | 
|POLY 1.5           |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.235         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.217         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.190         | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.261         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        1/14 (7%)       | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          1/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             7.6%            | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        1/11 (9%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.093          (e)              (e)              (e)              (e)              P=0.483         | 
|POLY 3             |        P=0.110          (e)              (e)              (e)              (e)              P=0.516         | 
|POLY 1.5           |        P=0.111          (e)              (e)              (e)              (e)              P=0.518         | 
|POLY 6             |        P=0.108          (e)              (e)              (e)              (e)              P=0.510         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.483         | 
|COCH-ARM / FISHERS |        P=0.108          (e)              (e)              (e)              (e)              P=0.519         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        5/12 (42%)      | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          5/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             45.8%           | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        5/9 (56%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.011 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.010 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.012 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.008 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.011 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.024 *       | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        3/14 (21%)      | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          3/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             22.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        3/11 (27%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.098         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.118         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.120         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.112         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.098         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.124         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        1/13 (8%)        0/10 (0%)        0/13 (0%)        2/12 (17%)      | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          1/10.32          0/9.27           0/12.59          2/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.7%             0.0%             0.0%             18.3%           | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        1/10 (10%)       0/9 (0%)         0/12 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.042 *        (e)              P=0.481          (e)              (e)              P=0.190         | 
|POLY 3             |        P=0.050          (e)              P=0.487          (e)              (e)              P=0.226         | 
|POLY 1.5           |        P=0.052          (e)              P=0.498          (e)              (e)              P=0.235         | 
|POLY 6             |        P=0.048 *        (e)              P=0.482          (e)              (e)              P=0.217         | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.481          (e)              (e)              P=0.190         | 
|COCH-ARM / FISHERS |        P=0.059          (e)              P=0.542          (e)              (e)              P=0.261         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        3/14 (21%)      | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          3/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             22.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        3/11 (27%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.098         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.118         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.120         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.112         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.098         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.124         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        2/12 (17%)      | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          2/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             18.3%           | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        2/9 (22%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.190         | 
|POLY 3             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.226         | 
|POLY 1.5           |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.235         | 
|POLY 6             |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.217         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.190         | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.261         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/13 (0%)        0/13 (0%)        0/14 (0%)        0/15 (0%)        0/14 (0%)        2/14 (14%)      | 
|POLY-3 RATE (b)    |        0/12.15          0/13.00          0/11.73          0/14.33          0/12.93          2/13.16         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             15.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/13 (0%)        0/11 (0%)        0/14 (0%)        0/12 (0%)        2/11 (18%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.216         | 
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.249         | 
|POLY 1.5           |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.251         | 
|POLY 6             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.242         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.216         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.259         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/10 (0%)        0/13 (0%)        0/12 (0%)       | 
|POLY-3 RATE (b)    |        0/11.00          0/13.85          0/10.32          0/9.27           0/12.59          0/10.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/11 (0%)        0/13 (0%)        0/10 (0%)        0/9 (0%)         0/12 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       1/15 (7%)        1/15 (7%)        1/14 (7%)        1/15 (7%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        2/14.15          1/15.00          1/12.73          1/13.33          1/13.93          2/14.02         | 
|POLY-3 PERCENT (g) |        14.1%            6.7%             7.9%             7.5%             7.2%             14.3%           | 
|TERMINAL (d)       |        2/14 (14%)       1/15 (7%)        1/12 (8%)        1/13 (8%)        1/13 (8%)        2/11 (18%)      | 
|FIRST INCIDENCE    |        192 (T)          192 (T)          192 (T)          192 (T)          192 (T)          192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.363          P=0.475N         P=0.555N         P=0.527N         P=0.527N         P=0.610         | 
|POLY 3             |        P=0.455          P=0.479N         P=0.538N         P=0.521N         P=0.505N         P=0.696         | 
|POLY 1.5           |        P=0.461          P=0.485N         P=0.527N         P=0.521N         P=0.504N         P=0.697N        | 
|POLY 6             |        P=0.442          P=0.476N         P=0.546N         P=0.524N         P=0.508N         P=0.683         | 
|LOGISTIC REGRESSION|        P=0.363          P=0.475N         P=0.555N         P=0.527N         P=0.527N         P=0.610         | 
|COCH-ARM / FISHERS |        P=0.458          P=0.500N         P=0.500N         P=0.527N         P=0.500N         P=0.701N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        2/15 (13%)       1/15 (7%)        2/15 (13%)       2/15 (13%)      | 
|POLY-3 RATE (b)    |        1/15.00          0/14.85          2/12.32          1/14.27          2/14.59          2/13.93         | 
|POLY-3 PERCENT (g) |        6.7%             0.0%             16.2%            7.0%             13.7%            14.4%           | 
|TERMINAL (d)       |        1/15 (7%)        0/14 (0%)        2/12 (17%)       1/14 (7%)        2/14 (14%)       2/12 (17%)      | 
|FIRST INCIDENCE    |        193 (T)          ---              193 (T)          193 (T)          193 (T)          193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.189          P=0.514N         P=0.420          P=0.749          P=0.475          P=0.420         | 
|POLY 3             |        P=0.216          P=0.502N         P=0.431          P=0.749          P=0.490          P=0.474         | 
|POLY 1.5           |        P=0.226          P=0.501N         P=0.446          P=0.753          P=0.495          P=0.483         | 
|POLY 6             |        P=0.207          P=0.504N         P=0.423          P=0.746          P=0.484          P=0.463         | 
|LOGISTIC REGRESSION|        P=0.189          (e)              P=0.420          P=0.749          P=0.475          P=0.420         | 
|COCH-ARM / FISHERS |        P=0.236          P=0.500N         P=0.500          P=0.759N         P=0.500          P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis, Skin, Site of Application                                                                                       | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        6/15 (40%)       14/15 (93%)      15/15 (100%)    | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          0/12.73          6/14.33          14/14.82         15/15.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             41.9%            94.4%            100.0%          | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        6/14 (43%)       13/13 (100%)     11/11 (100%)    | 
|FIRST INCIDENCE    |        ---              ---              ---              192 (T)          92               161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.012 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.005 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.005 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.005 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.012 *        P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.008 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis, Skin, Site of Application                                                                                       | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        4/15 (27%)       15/15 (100%)     15/15 (100%)    | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          4/14.27          15/15.00         15/15.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             28.0%            100.0%           100.0%          | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        4/14 (29%)       14/14 (100%)     12/12 (100%)    | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          193 (T)          162              118             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.455          P=0.048 *        P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.461          P=0.039 *        P<0.001N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.470          P=0.041 *        P<0.001N**       P<0.001N**      | 
|POLY 6             |        P<0.001 **       (e)              P=0.457          P=0.038 *        P<0.001N**       P<0.001N**      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.455          P=0.048 *        (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P=0.050          P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis, Skin, Site of Application                                                                                       | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        1/15 (7%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          1/12.73          0/14.33          1/13.93          0/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.9%             0.0%             7.2%             0.0%            | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        1/12 (8%)        0/14 (0%)        1/13 (8%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              192 (T)          ---              192 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.683          (e)              P=0.469          (e)              P=0.485          (e)             | 
|POLY 3             |        P=0.696          (e)              P=0.479          (e)              P=0.497          (e)             | 
|POLY 1.5           |        P=0.691N         (e)              P=0.485          (e)              P=0.498          (e)             | 
|POLY 6             |        P=0.679          (e)              P=0.474          (e)              P=0.495          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.469          (e)              P=0.485          (e)             | 
|COCH-ARM / FISHERS |        P=0.684N         (e)              P=0.500          (e)              P=0.500          (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis, Skin, Site of Application                                                                                       | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        1/15 (7%)        8/15 (53%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          0/12.32          1/14.27          1/14.59          8/14.70         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             7.0%             6.9%             54.4%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        1/14 (7%)        1/14 (7%)        7/12 (58%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              193 (T)          193 (T)          118             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.486          P=0.486          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.490          P=0.494          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.493          P=0.497          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.487          P=0.491          P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.486          P=0.486          P=0.003 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.500          P=0.500          P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        15/15 (100%)     14/15 (93%)      12/15 (80%)     | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          1/13.18          15/15.00         14/14.82         12/15.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.6%             100.0%           94.4%            80.0%           | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        14/14 (100%)     13/13 (100%)     8/11 (73%)      | 
|FIRST INCIDENCE    |        ---              ---              157              132              92               161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.485          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.486          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.489          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.485          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.557          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        7/15 (47%)       14/15 (93%)      13/15 (87%)     | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          1/12.32          7/14.27          14/15.00         13/14.23        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             8.1%             49.1%            93.3%            91.4%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        1/12 (8%)        7/14 (50%)       13/14 (93%)      11/12 (92%)     | 
|FIRST INCIDENCE    |        ---              ---              193 (T)          193 (T)          162              176             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.455          P=0.004 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.461          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.470          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.457          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.455          P=0.004 **       (e)              P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P=0.003 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        1/15 (7%)        9/15 (60%)       12/15 (80%)     | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          1/12.73          1/15.00          9/13.93          12/14.59        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.9%             6.7%             64.6%            82.3%           | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        1/12 (8%)        0/14 (0%)        9/13 (69%)       9/11 (82%)      | 
|FIRST INCIDENCE    |        ---              ---              192 (T)          132              192 (T)          161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.469          P=0.514          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.479          P=0.512          P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.485          P=0.508          P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.474          P=0.513          P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.469          P=0.324          P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P=0.500          P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Skin, Site of Application                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        3/15 (20%)       14/15 (93%)      12/15 (80%)     | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          0/12.32          3/14.27          14/15.00         12/13.99        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             21.0%            93.3%            85.8%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        3/14 (21%)       13/14 (93%)      11/12 (92%)     | 
|FIRST INCIDENCE    |        ---              ---              ---              193 (T)          162              189             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.104          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.097          P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.100          P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.094          P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.104          (e)              P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.112          P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        1/15 (7%)        4/15 (27%)      | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          1/13.18          0/14.33          1/14.11          4/15.00         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.6%             0.0%             7.1%             26.7%           | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              157              ---              180              161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       (e)              P=0.485          (e)              P=0.500          P=0.062         | 
|POLY 3             |        P<0.001 **       (e)              P=0.486          (e)              P=0.499          P=0.052         | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.489          (e)              P=0.499          P=0.050         | 
|POLY 6             |        P<0.001 **       (e)              P=0.485          (e)              P=0.500          P=0.054         | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.557          (e)              P=0.503          P=0.033 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          (e)              P=0.500          P=0.050         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        3/15 (20%)       1/15 (7%)        2/15 (13%)       1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/15.00          1/15.00          3/15.00          1/15.00          2/15.00          1/13.99         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             20.0%            6.7%             13.3%            7.2%            | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        1/14 (7%)        0/12 (0%)       | 
|FIRST INCIDENCE    |        ---              183              63               124              162              189             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.545          P=0.500          P=0.113          P=0.500          P=0.232          P=0.471         | 
|POLY 3             |        P=0.522          P=0.500          P=0.106          P=0.500          P=0.232          P=0.486         | 
|POLY 1.5           |        P=0.536          P=0.500          P=0.106          P=0.500          P=0.232          P=0.491         | 
|POLY 6             |        P=0.507          P=0.500          P=0.106          P=0.500          P=0.232          P=0.481         | 
|LOGISTIC REGRESSION|        P=0.610          (e)              (e)              (e)              (e)              P=0.506         | 
|COCH-ARM / FISHERS |        P=0.562          P=0.500          P=0.112          P=0.500          P=0.241          P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        4/15 (27%)       1/15 (7%)        2/15 (13%)       6/15 (40%)       8/15 (53%)      | 
|POLY-3 RATE (b)    |        1/15.00          4/15.00          1/12.73          2/14.33          6/13.93          8/14.02         | 
|POLY-3 PERCENT (g) |        6.7%             26.7%            7.9%             14.0%            43.1%            57.1%           | 
|TERMINAL (d)       |        0/14 (0%)        4/15 (27%)       1/12 (8%)        2/14 (14%)       6/13 (46%)       8/11 (73%)      | 
|FIRST INCIDENCE    |        101              192 (T)          192 (T)          192 (T)          192 (T)          192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.192          P=0.727          P=0.500          P=0.039 *        P=0.003 **      | 
|POLY 3             |        P<0.001 **       P=0.163          P=0.723          P=0.484          P=0.025 *        P=0.002 **      | 
|POLY 1.5           |        P<0.001 **       P=0.163          P=0.734          P=0.490          P=0.027 *        P=0.002 **      | 
|POLY 6             |        P<0.001 **       P=0.163          P=0.715          P=0.478          P=0.023 *        P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.192          P=0.691N         P=0.422          P=0.042 *        P=0.007 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.165          P=0.759N         P=0.500          P=0.040 *        P=0.007 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/15 (47%)       13/15 (87%)      9/15 (60%)       6/15 (40%)       8/15 (53%)       10/15 (67%)     | 
|POLY-3 RATE (b)    |        7/15.00          13/14.85         9/12.32          6/14.27          8/14.59          10/14.70        | 
|POLY-3 PERCENT (g) |        46.7%            87.5%            73.0%            42.1%            54.8%            68.0%           | 
|TERMINAL (d)       |        7/15 (47%)       13/14 (93%)      9/12 (75%)       6/14 (43%)       8/14 (57%)       9/12 (75%)      | 
|FIRST INCIDENCE    |        193 (T)          193 (T)          193 (T)          193 (T)          193 (T)          118             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.274          P=0.012 *        P=0.141          P=0.565N         P=0.425          P=0.086         | 
|POLY 3             |        P=0.526          P=0.016 *        P=0.159          P=0.547N         P=0.470          P=0.211         | 
|POLY 1.5           |        P=0.526          P=0.018 *        P=0.197          P=0.531N         P=0.483          P=0.222         | 
|POLY 6             |        P=0.506          P=0.014 *        P=0.143          P=0.560N         P=0.452          P=0.194         | 
|LOGISTIC REGRESSION|        P=0.460          P=0.012 *        P=0.141          P=0.565N         P=0.425          P=0.268         | 
|COCH-ARM / FISHERS |        P=0.482          P=0.025 *        P=0.358          P=0.500N         P=0.500          P=0.231         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        1/15 (7%)        1/15 (7%)        1/15 (7%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/14.15          1/15.00          1/13.67          1/14.33          1/13.93          0/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             7.3%             7.0%             7.2%             0.0%            | 
|TERMINAL (d)       |        0/14 (0%)        1/15 (7%)        0/12 (0%)        1/14 (7%)        1/13 (8%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              192 (T)          74               192 (T)          192 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.484N         P=0.514          P=0.500          P=0.500          P=0.485          (e)             | 
|POLY 3             |        P=0.446N         P=0.512          P=0.493          P=0.503          P=0.497          (e)             | 
|POLY 1.5           |        P=0.441N         P=0.508          P=0.496          P=0.503          P=0.498          (e)             | 
|POLY 6             |        P=0.457N         P=0.513          P=0.490          P=0.501          P=0.495          (e)             | 
|LOGISTIC REGRESSION|        P=0.485N         P=0.514          (e)              P=0.500          P=0.485          (e)             | 
|COCH-ARM / FISHERS |        P=0.438N         P=0.500          P=0.500          P=0.500          P=0.500          (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       2/15 (13%)       2/15 (13%)       0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        2/15.00          2/14.85          2/12.32          0/14.27          0/14.59          0/13.93         | 
|POLY-3 PERCENT (g) |        13.3%            13.5%            16.2%            0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        2/15 (13%)       2/14 (14%)       2/12 (17%)       0/14 (0%)        0/14 (0%)        0/12 (0%)       | 
|FIRST INCIDENCE    |        193 (T)          193 (T)          193 (T)          ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.062N         P=0.676          P=0.617          P=0.251N         P=0.251N         P=0.286N        | 
|POLY 3             |        P=0.053N         P=0.695          P=0.624          P=0.243N         P=0.238N         P=0.249N        | 
|POLY 1.5           |        P=0.052N         P=0.696          P=0.642          P=0.239N         P=0.235N         P=0.242N        | 
|POLY 6             |        P=0.054N         P=0.692          P=0.616          P=0.246N         P=0.242N         P=0.256N        | 
|LOGISTIC REGRESSION|        P=0.062N         P=0.676          P=0.617          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.053N         P=0.701N         P=0.701N         P=0.241N         P=0.241N         P=0.241N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          0/12.73          0/14.33          0/13.93          0/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Myelodysplasia                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          0/12.32          0/14.27          0/14.59          2/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.4%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        2/12 (17%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.188         | 
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.214         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.221         | 
|POLY 6             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.208         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.188         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        1/15 (7%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          1/13.60          0/14.33          1/13.93          3/14.59         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.4%             0.0%             7.2%             20.6%           | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        0/14 (0%)        1/13 (8%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              95               ---              192 (T)          161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.009 **       (e)              P=0.486          (e)              P=0.485          P=0.115         | 
|POLY 3             |        P=0.008 **       (e)              P=0.492          (e)              P=0.497          P=0.111         | 
|POLY 1.5           |        P=0.008 **       (e)              P=0.494          (e)              P=0.498          P=0.111         | 
|POLY 6             |        P=0.008 **       (e)              P=0.489          (e)              P=0.495          P=0.110         | 
|LOGISTIC REGRESSION|        P=0.004 **       (e)              P=0.772          (e)              P=0.485          P=0.092         | 
|COCH-ARM / FISHERS |        P=0.009 **       (e)              P=0.500          (e)              P=0.500          P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          0/12.32          0/14.27          0/14.59          0/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        0/12 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       0/15 (0%)        1/15 (7%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        2/14.15          0/15.00          1/13.18          0/14.33          0/13.93          1/14.02         | 
|POLY-3 PERCENT (g) |        14.1%            0.0%             7.6%             0.0%             0.0%             7.1%            | 
|TERMINAL (d)       |        2/14 (14%)       0/15 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        1/11 (9%)       | 
|FIRST INCIDENCE    |        192 (T)          ---              157              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.593N         P=0.221N         P=0.545N         P=0.236N         P=0.252N         P=0.587N        | 
|POLY 3             |        P=0.563N         P=0.218N         P=0.525N         P=0.228N         P=0.234N         P=0.503N        | 
|POLY 1.5           |        P=0.559N         P=0.222N         P=0.520N         P=0.228N         P=0.233N         P=0.498N        | 
|POLY 6             |        P=0.565N         P=0.216N         P=0.526N         P=0.230N         P=0.236N         P=0.516N        | 
|LOGISTIC REGRESSION|        P=0.552N         (e)              P=0.499N         (e)              (e)              P=0.587N        | 
|COCH-ARM / FISHERS |        P=0.550N         P=0.241N         P=0.500N         P=0.241N         P=0.241N         P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Unilateral, Germinal Epithelium                                                                                          | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/15 (27%)       0/15 (0%)        3/15 (20%)       1/15 (7%)        1/15 (7%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        4/14.15          0/15.00          3/14.06          1/14.33          1/13.93          2/14.02         | 
|POLY-3 PERCENT (g) |        28.3%            0.0%             21.3%            7.0%             7.2%             14.3%           | 
|TERMINAL (d)       |        4/14 (29%)       0/15 (0%)        1/12 (8%)        1/14 (7%)        1/13 (8%)        2/11 (18%)      | 
|FIRST INCIDENCE    |        192 (T)          ---              95               192 (T)          192 (T)          192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.520N         P=0.048N*        P=0.573N         P=0.166N         P=0.189N         P=0.449N        | 
|POLY 3             |        P=0.462N         P=0.038N*        P=0.504N         P=0.157N         P=0.166N         P=0.330N        | 
|POLY 1.5           |        P=0.451N         P=0.040N*        P=0.506N         P=0.157N         P=0.164N         P=0.324N        | 
|POLY 6             |        P=0.475N         P=0.037N*        P=0.501N         P=0.159N         P=0.168N         P=0.348N        | 
|LOGISTIC REGRESSION|        P=0.446N         (e)              P=0.449N         P=0.166N         P=0.189N         P=0.449N        | 
|COCH-ARM / FISHERS |        P=0.434N         P=0.050N         P=0.500N         P=0.165N         P=0.165N         P=0.326N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Unilateral, Germinal Epithelium                                                                                          | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        1/14 (7%)        0/15 (0%)        2/15 (13%)       5/15 (33%)      | 
|POLY-3 RATE (b)    |        1/14.15          0/15.00          1/12.18          0/14.33          2/15.00          5/15.00         | 
|POLY-3 PERCENT (g) |        7.1%             0.0%             8.2%             0.0%             13.3%            33.3%           | 
|TERMINAL (d)       |        1/14 (7%)        0/15 (0%)        0/11 (0%)        0/14 (0%)        0/13 (0%)        1/11 (9%)       | 
|FIRST INCIDENCE    |        192 (T)          ---              157              ---              92               161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.486N         P=0.725          P=0.500N         P=0.491          P=0.086         | 
|POLY 3             |        P<0.001 **       P=0.488N         P=0.727          P=0.497N         P=0.521          P=0.094         | 
|POLY 1.5           |        P<0.001 **       P=0.492N         P=0.731          P=0.497N         P=0.515          P=0.089         | 
|POLY 6             |        P<0.001 **       P=0.487N         P=0.726          P=0.499N         P=0.524          P=0.096         | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.774          (e)              P=0.526          P=0.071         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.741          P=0.500N         P=0.500          P=0.084         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        1/15 (7%)        3/15 (20%)       2/15 (13%)       2/15 (13%)       3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/15.00          1/15.00          3/15.00          2/15.00          2/15.00          3/15.00         | 
|POLY-3 PERCENT (g) |        0.0%             6.7%             20.0%            13.3%            13.3%            20.0%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        1/14 (7%)        1/14 (7%)        0/12 (0%)       | 
|FIRST INCIDENCE    |        ---              183              63               124              162              118             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.146          P=0.500          P=0.113          P=0.232          P=0.232          P=0.112         | 
|POLY 3             |        P=0.146          P=0.500          P=0.106          P=0.232          P=0.232          P=0.106         | 
|POLY 1.5           |        P=0.146          P=0.500          P=0.106          P=0.232          P=0.232          P=0.106         | 
|POLY 6             |        P=0.146          P=0.500          P=0.106          P=0.232          P=0.232          P=0.106         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.143          P=0.500          P=0.112          P=0.241          P=0.241          P=0.112         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus: Thymocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/14 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          0/11.73          0/14.33          0/13.93          1/14.43         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             6.9%            | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/11 (0%)        0/14 (0%)        0/13 (0%)        0/11 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              161             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.117          (e)              (e)              (e)              (e)              P=0.514         | 
|POLY 3             |        P=0.111          (e)              (e)              (e)              (e)              P=0.504         | 
|POLY 1.5           |        P=0.111          (e)              (e)              (e)              (e)              P=0.504         | 
|POLY 6             |        P=0.110          (e)              (e)              (e)              (e)              P=0.500         | 
|LOGISTIC REGRESSION|        P=0.078          (e)              (e)              (e)              (e)              P=0.410         | 
|COCH-ARM / FISHERS |        P=0.107          (e)              (e)              (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus: Thymocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        2/15 (13%)       1/15 (7%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          2/14.04          1/15.00          0/14.59          1/13.99         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             14.3%            6.7%             0.0%             7.2%            | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        0/12 (0%)       | 
|FIRST INCIDENCE    |        ---              ---              63               124              ---              189             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.518          (e)              P=0.224          P=0.500          (e)              P=0.471         | 
|POLY 3             |        P=0.497          (e)              P=0.216          P=0.500          (e)              P=0.486         | 
|POLY 1.5           |        P=0.506          (e)              P=0.219          P=0.500          (e)              P=0.491         | 
|POLY 6             |        P=0.489          (e)              P=0.216          P=0.500          (e)              P=0.481         | 
|LOGISTIC REGRESSION|        P=0.406          (e)              P=0.829          (e)              (e)              P=0.506         | 
|COCH-ARM / FISHERS |        P=0.525          (e)              P=0.241          P=0.500          (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/14.15          0/15.00          0/12.73          0/14.33          0/13.93          1/14.02         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             7.1%            | 
|TERMINAL (d)       |        0/14 (0%)        0/15 (0%)        0/12 (0%)        0/14 (0%)        0/13 (0%)        1/11 (9%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              192 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.082          (e)              (e)              (e)              (e)              P=0.452         | 
|POLY 3             |        P=0.106          (e)              (e)              (e)              (e)              P=0.498         | 
|POLY 1.5           |        P=0.107          (e)              (e)              (e)              (e)              P=0.501         | 
|POLY 6             |        P=0.103          (e)              (e)              (e)              (e)              P=0.491         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.452         | 
|COCH-ARM / FISHERS |        P=0.105          (e)              (e)              (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)      | 
|POLY-3 RATE (b)    |        0/15.00          0/14.85          0/12.32          0/14.27          0/14.59          2/13.93         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             14.4%           | 
|TERMINAL (d)       |        0/15 (0%)        0/14 (0%)        0/12 (0%)        0/14 (0%)        0/14 (0%)        2/12 (17%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              193 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.188         | 
|POLY 3             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.214         | 
|POLY 1.5           |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.221         | 
|POLY 6             |        P=0.009 **       (e)              (e)              (e)              (e)              P=0.208         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.188         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.241         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88133 TEST: 06                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -       TRIMETHYLOLPROPANE TRIACRYLATE 
(TMPTA)                                                                                                                             
                                         Terminal Sacrifice at 28 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/15 (67%)      11/15 (73%)      7/15 (47%)       8/15 (53%)       8/15 (53%)       9/15 (60%)      | 
|POLY-3 RATE (b)    |        10/15.00         11/14.85         7/12.32          8/14.27          8/14.59          9/13.99         | 
|POLY-3 PERCENT (g) |        66.7%            74.1%            56.8%            56.1%            54.8%            64.4%           | 
|TERMINAL (d)       |        10/15 (67%)      11/14 (79%)      7/12 (58%)       8/14 (57%)       8/14 (57%)       8/12 (67%)      | 
|FIRST INCIDENCE    |        193 (T)          193 (T)          193 (T)          193 (T)          193 (T)          189             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.493          P=0.384          P=0.483N         P=0.443N         P=0.443N         P=0.489         | 
|POLY 3             |        P=0.428N         P=0.484          P=0.449N         P=0.419N         P=0.391N         P=0.600N        | 
|POLY 1.5           |        P=0.411N         P=0.492          P=0.394N         P=0.397N         P=0.376N         P=0.563N        | 
|POLY 6             |        P=0.456N         P=0.470          P=0.476N         P=0.437N         P=0.412N         P=0.637N        | 
|LOGISTIC REGRESSION|        P=0.566          P=0.384          P=0.483N         P=0.443N         P=0.443N         P=0.596         | 
|COCH-ARM / FISHERS |        P=0.425N         P=0.500          P=0.231N         P=0.355N         P=0.355N         P=0.500N        | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.