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TDMS Study 88133-06 Pathology Tables

NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16

                                                            Final#2




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  15625-89-5

       Lock Date:  06/16/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 001    0 MG/KG
                               Include 004    0.75    MG/KG
                               Include 003    0.75    MG/KG
                               Include 006    1.5     MG/KG
                               Include 005    1.5     MG/KG
                               Include 008    3 MG/KG
                               Include 007    3 MG/KG
                               Include 010    6 MG/KG
                               Include 009    6 MG/KG
                               Include 012    12 MG/KG
                               Include 011    12 MG/KG






















a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                                   1            2            1            1            3           
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           14           12           14           14           12           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                           1 [2.0]                                6 [1.8]     
      Infiltration Cellular                                                      1 [2.0]                                1 [2.0]     
      Inflammation, Chronic Active                    15 [1.1]     14 [1.1]     13 [1.2]     13 [1.0]     14 [1.0]      8 [1.3]     
      Myelodysplasia                                                                                                    2 [2.5]     
      Pigmentation                                    12 [1.0]     15 [1.1]     12 [1.0]     13 [1.0]     14 [1.0]      4 [1.0]     
      Hepatocyte, Necrosis                             4 [1.3]      2 [1.0]      1 [1.0]      2 [1.0]      1 [1.0]      1 [1.0]     
   Salivary Glands                                    (1)                                                              (1)          
      Parotid Gland, Infiltration Cellular                                                                              1 [1.0]     
   Tooth                                              (1)          (4)          (3)          (1)          (3)          (2)          
      Fibrosis                                                                                                          1 [4.0]     
      Inflammation, Chronic Active                                                            1 [4.0]                               
      Malformation                                                               1                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                                                                                      1 [1.0]     
      Atrium, Thrombosis                                                                                                1 [4.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (15)         (15)         (15)         (15)         (15)         (15)         
      Pars Distalis, Angiectasis                                                              1 [1.0]                               
      Pars Distalis, Cyst                              1 [1.0]                   2 [1.0]      1 [1.0]      2 [1.5]      2 [1.0]     
   Thyroid Gland                                      (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular                                                                                             1 [2.0]     
      Inflammation, Chronic Active                                                                                      2 [1.5]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Cyst                                             1 [2.0]                                1 [2.0]                   1 [2.0]     
      Inflammation, Chronic Active                                                            1 [2.0]      1 [2.0]                  
      Pigmentation                                     1 [2.0]      1 [2.0]                                                         
   Uterus                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hydrometra                                                    1 [2.0]                   1 [2.0]      1 [4.0]      1 [2.0]     
      Inflammation, Chronic Active                     1 [2.0]                                                                      
      Cervix, Inflammation, Chronic Active                          1 [2.0]                                                         
      Endometrium, Hyperplasia, Cystic                10 [1.6]     11 [1.6]      7 [1.4]      8 [1.8]      8 [1.8]      9 [1.7]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (11)         (14)         (13)         (10)         (13)         (12)         
      Hematopoietic Cell Proliferation                                                                                  2 [3.0]     
      Hyperplasia                                                                                                       2 [3.5]     
      Inguinal, Hematopoietic Cell Proliferation                                                                        1 [2.0]     
      Inguinal, Hyperplasia                                                                                             1 [2.0]     
      Inguinal, Infiltration Cellular, Plasma Cell                                                                      2 [3.0]     
      Inguinal, Myelodysplasia                                                                                          2 [2.5]     
      Mediastinal, Hematopoietic Cell Proliferation                                                                     5 [2.0]     
      Mediastinal, Infiltration Cellular                                         1 [2.0]                                2 [2.0]     
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                                                          2 [2.0]     
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                           1 [3.0]                                6 [2.0]     
      Hyperplasia                                      1 [2.0]      3 [3.3]      2 [2.5]                   2 [3.0]      3 [2.0]     
      Hyperplasia, Plasma Cell                                                   1 [2.0]                   1 [4.0]                  
      Infiltration Cellular                                                      1 [3.0]                                1 [3.0]     
      Infiltration Cellular, Plasma Cell                                         1 [3.0]                                2 [2.5]     
      Inflammation, Chronic Active                                               1 [3.0]                                            
      Myelodysplasia                                                                                                    1 [3.0]     
   Lymph Node, Mesenteric                             (15)         (14)         (14)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                                                                                  4 [2.0]     
      Infiltration Cellular                                                                                             2 [2.5]     
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Atrophy                                                       1 [1.0]      3 [2.3]      1 [2.0]      2 [2.0]      1 [3.0]     
      Hematopoietic Cell Proliferation                 7 [1.1]     13 [1.8]      9 [1.6]      6 [1.8]      8 [1.8]     10 [2.7]     
      Hyperplasia, Lymphoid                            2 [1.0]      2 [2.0]      2 [3.5]                                            
      Infiltration Cellular                                                                                             1 [1.0]     
      Myelodysplasia                                                                                                    2 [2.0]     
   Thymus                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                                       1 [4.0]      3 [3.3]      2 [3.0]      2 [3.5]      3 [3.7]     
      Thymocyte, Necrosis                                                        2 [3.0]      1 [4.0]                   1 [3.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                            1 [2.0]      4 [1.0]     15 [1.2]     15 [2.0]     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia, Focal                                                                  1 [4.0]      1 [3.0]      8 [2.8]     
      Skin, Site of Application, Hyperkeratosis                                  1 [1.0]      7 [1.0]     14 [1.1]     13 [1.6]     
      Skin, Site of Application, Hyperplasia                                                               1 [1.0]                  
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                                                     3 [1.0]     14 [1.0]     12 [1.3]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                                               1 [1.0]                                            
      Mediastinum, Infiltration Cellular                                                                                1 [2.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                                               2 [1.0]                                3 [1.0]     
      Mineralization                                                                                                    1 [1.0]     
      Nephropathy                                      4 [1.0]                                                          1 [1.0]     
      Renal Tubule, Cyst                                                                                                1 [2.0]     
      Renal Tubule, Regeneration                                    1 [1.0]                                2 [1.0]      1 [1.0]     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                      1                         3            1            2            4           
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           15           12           14           13           11           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Basophilic Focus                                              1                                                               
      Hematopoietic Cell Proliferation                 1 [1.0]                   1 [1.0]                                6 [1.3]     
      Infarct                                                       1 [4.0]                                                         
      Infiltration Cellular                                                                                             5 [1.6]     
      Inflammation, Acute                                           1 [1.0]                                                         
      Inflammation, Chronic Active                     7 [1.1]     10 [1.0]      8 [1.0]      8 [1.0]      7 [1.0]      8 [1.3]     
      Mineralization                                                1 [1.0]                                                         
      Myelodysplasia                                                                                                    1 [1.0]     
      Pigmentation                                                  2 [1.0]                                                         
      Hepatocyte, Necrosis                             2 [1.5]      2 [1.0]      2 [1.0]                   1 [1.0]      1 [2.0]     
   Mesentery                                                                                              (1)          (1)          
      Fat, Necrosis                                                                                        1 [4.0]      1 [4.0]     
   Salivary Glands                                                              (1)          (1)                       (2)          
      Mandibular, Infiltration Cellular                                                                                 1 [1.0]     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperkeratosis                                                             1 [2.0]                   1 [2.0]      3 [2.0]     
      Inflammation, Chronic Active                                                                         1 [3.0]                  
      Epithelium, Hyperplasia                                                                              1 [4.0]                  
   Tooth                                              (1)          (3)          (1)          (2)          (1)          (1)          
      Inflammation, Chronic Active                                                            1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Atrium, Thrombosis                                                         1 [4.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Cortex                                     (15)         (15)         (15)         (15)         (15)         (15)         
      Hyperplasia                                                                                                       1 [1.0]     
      Hypertrophy                                      7 [1.6]      5 [1.8]      9 [1.7]      8 [1.3]      5 [1.4]      5 [1.4]     
      Vacuolization Cytoplasmic                                                                                         1 [1.0]     
   Pituitary Gland                                    (15)         (15)         (15)         (14)         (15)         (15)         
      Pars Distalis, Cyst                              2 [1.0]      1 [1.0]      1 [2.0]      1 [1.0]      1 [1.0]      2 [1.0]     
   Thyroid Gland                                      (15)         (15)         (15)         (15)         (15)         (15)         
      Inflammation, Chronic Active                                                                                      1 [1.0]     
      Follicle, Cyst                                                             1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                                       1 [2.0]                                                         
      Inflammation, Chronic Active                                  2 [1.5]                                             3 [2.3]     
      Myelodysplasia                                                                                                    1 [3.0]     
      Bilateral, Hypospermia                                        1 [4.0]                                                         
      Unilateral, Hypospermia                          4 [3.8]                   3 [4.0]      1 [4.0]      1 [4.0]      2 [4.0]     
   Preputial Gland                                    (1)                                                              (1)          
      Inflammation, Chronic Active                                                                                      1 [3.0]     
      Duct, Ectasia                                    1 [2.0]                                                                      
   Testes                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Cyst                                             2 [2.0]                   1 [2.0]                                1 [2.0]     
      Bilateral, Germinal Epithelium, Degeneration                  1 [4.0]                                                         
      Germinal Epithelium, Degeneration                                                                                 1 [1.0]     
      Unilateral, Germinal Epithelium, Degeneration    4 [2.5]                   3 [2.7]      1 [2.0]      1 [2.0]      2 [2.5]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (13)         (13)         (14)         (15)         (14)         (14)         
      Hyperplasia                                                                                                       4 [3.5]     
      Inflammation, Chronic Active                                                                                      3 [2.3]     
      Axillary, Infiltration Cellular                                                                                   1 [3.0]     
      Axillary, Infiltration Cellular, Plasma Cell                                                                      1 [3.0]     
      Inguinal, Hyperplasia                                                                                             1 [4.0]     
      Inguinal, Inflammation, Chronic Active                                                                            1 [2.0]     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Hematopoietic Cell Proliferation                                                                     1 [2.0]     
      Mediastinal, Hyperplasia                                                                                          1 [2.0]     
      Mediastinal, Infiltration Cellular                                                                                3 [2.3]     
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                                                          3 [2.3]     
      Mediastinal, Inflammation, Chronic Active                                                                         2 [2.0]     
   Lymph Node, Mandibular                             (15)         (14)         (15)         (15)         (14)         (13)         
      Hematopoietic Cell Proliferation                                                                                  2 [1.5]     
      Hyperplasia                                                   1 [2.0]                                             1 [2.0]     
      Hyperplasia, Plasma Cell                                                   1 [3.0]                   1 [2.0]                  
      Infiltration Cellular                                                                                             4 [1.8]     
      Infiltration Cellular, Plasma Cell                                                                                1 [2.0]     
   Lymph Node, Mesenteric                             (15)         (14)         (14)         (15)         (15)         (12)         
      Infiltration Cellular                                                                                             1 [1.0]     
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Atrophy                                                                    1 [2.0]                   1 [1.0]      4 [1.8]     
      Depletion Cellular                                                         1 [3.0]                   1 [2.0]                  
      Hematopoietic Cell Proliferation                 1 [2.0]      4 [1.5]      1 [3.0]      2 [1.5]      6 [2.0]      8 [2.6]     
      Hyperplasia, Lymphoid                                         1 [1.0]      1 [4.0]      1 [1.0]      1 [1.0]                  
   Thymus                                             (15)         (15)         (14)         (15)         (15)         (15)         
      Atrophy                                          1 [2.0]                   1 [4.0]                   2 [3.5]      5 [3.0]     
      Thymocyte, Necrosis                                                                                               1 [2.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                                         6 [1.0]     14 [1.7]     15 [1.9]     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia, Focal                                                     1 [4.0]                   1 [4.0]                  
      Skin, Site of Application, Hyperkeratosis                                  1 [2.0]     15 [1.0]     14 [1.1]     12 [1.7]     
      Skin, Site of Application, Hyperplasia                                                                            1 [3.0]     
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                                        1 [1.0]      1 [1.0]      9 [1.1]     12 [1.3]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88133-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/12/02    
Route: SKIN APPLICATION                             TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                        Time: 08:54:16    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE            0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG     
                                                                   MG/KG        MG/KG                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (14)         
      Inflammation, Chronic Active                                  2 [1.0]                                             2 [1.5]     
      Thrombosis                                                                              1 [4.0]                               
      Interstitium, Hyperplasia                        1 [1.0]                                                                      
      Interstitium, Inflammation, Chronic Active                                 1 [3.0]                                            
      Mediastinum, Infiltration Cellular                                                                                1 [1.0]     
      Mediastinum, Inflammation, Chronic Active                                                                         1 [2.0]     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Infarct                                                                                              1 [3.0]      1 [2.0]     
      Infiltration Cellular                                                                                             1 [1.0]     
      Infiltration Cellular, Mononuclear Cell          1 [1.0]      1 [1.0]                                             1 [1.0]     
      Inflammation, Chronic Active                                  2 [1.0]      1 [1.0]                   1 [1.0]      5 [1.2]     
      Mineralization                                                                                       1 [1.0]                  
      Nephropathy                                      3 [1.0]      6 [1.0]                                             3 [1.0]     
      Glomerulus, Renal Tubule, Dilatation                                                                 1 [2.0]                  
      Renal Tubule, Cyst                               1 [2.0]      1 [2.0]                                             1 [1.0]     
      Renal Tubule, Hyperplasia                        1 [1.0]                   1 [1.0]                   1 [2.0]      1 [2.0]     
      Renal Tubule, Regeneration                       2 [1.0]      1 [1.0]      5 [1.0]      4 [1.0]      4 [1.0]                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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