TDMS Study 89002-01 Pathology Tables
NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:26:51 28 DAY Facility: Battelle Columbus Laboratory Chemical CAS #: 0000087-86-5 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:26:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Moribund Sacrifice 1 Natural Death 1 Survivors Terminal Sacrifice 10 10 10 10 10 8 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) (9) Angiectasis 1 (10%) Hepatodiaphragmatic Nodule 3 (30%) 2 (20%) 2 (20%) 3 (30%) 2 (22%) Hepatocyte, Degeneration 1 (10%) 6 (60%) 8 (80%) 8 (89%) Hepatocyte, Centrilobular, Hypertrophy 1 (10%) 7 (78%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (10) (10) (9) Cardiomyopathy 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (10) (10) (10) (10) (9) Inflammation, Chronic Active 1 (10%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:26:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Thymus (10) (10) (10) (10) (10) (9) Degeneration 1 (11%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) (10) (10) Hemorrhage, Acute 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) (10) (9) Inflammation, Chronic Active 1 (10%) 1 (10%) 1 (10%) 3 (33%) Nose (10) (10) (10) (10) (10) (10) Inflammation, Suppurative 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (9) Mineralization 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 8 (89%) Nephropathy, Chronic 6 (60%) 3 (30%) 5 (50%) 3 (30%) 2 (20%) 3 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:26:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Moribund Sacrifice 1 Survivors Terminal Sacrifice 10 10 10 10 10 9 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) (10) Basophilic Focus 1 (10%) Hepatodiaphragmatic Nodule 2 (20%) 2 (20%) 1 (10%) 1 (10%) Hepatocyte, Degeneration 4 (40%) 7 (70%) 9 (90%) 10 (100%) Hepatocyte, Necrosis 1 (10%) Hepatocyte, Centrilobular, Hypertrophy 3 (30%) 6 (60%) Salivary Glands (10) (10) (10) (10) (10) (10) Inflammation, Chronic Active 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) (10) (10) (10) (10) Cardiomyopathy 2 (20%) 7 (70%) 6 (60%) 2 (20%) 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) (10) (10) (10) (10) Hyperplasia 1 (10%) Inflammation, Chronic Active 3 (30%) Prostate (10) (10) (10) (10) (10) (10) Inflammation 1 (10%) Inflammation, Chronic Active 1 (10%) Testes (10) (10) (10) (10) (10) (10) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89002-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 28 DAY PENTACHLOROPHENOL Date: 10/28/97 Route: DOSED FEED Time: 08:26:51 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 800 PPM 1600 PPM 3200 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Germinal Epithelium, Degeneration 10 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) (10) (10) Inflammation, Chronic Active 3 (30%) 1 (10%) 2 (20%) 4 (40%) Nose (10) (10) (10) (10) (10) (10) Inflammation, Chronic Active 10 (100%) 1 (10%) 5 (50%) 3 (30%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) Mineralization 4 (40%) 2 (20%) 1 (10%) Nephropathy, Chronic 7 (70%) 9 (90%) 5 (50%) 8 (80%) 7 (70%) 3 (30%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------