https://ntp.niehs.nih.gov/go/4979

TDMS Study 89002-01 Pathology Tables

NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97
Route: DOSED FEED                                                                                                 Time: 08:26:51
                                                             28 DAY
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  0000087-86-5
       Lock Date:  07/13/95
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
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         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                  1           
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            8           
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (9)          
      Angiectasis                                                                             1 (10%)                               
      Hepatodiaphragmatic Nodule                       3 (30%)                   2 (20%)      2 (20%)      3 (30%)      2 (22%)     
      Hepatocyte, Degeneration                                                   1 (10%)      6 (60%)      8 (80%)      8 (89%)     
      Hepatocyte, Centrilobular, Hypertrophy                                                               1 (10%)      7 (78%)     
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 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)         (10)         (10)         (10)         (10)         (9)          
      Cardiomyopathy                                                1 (10%)                                                         
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (10)         (10)         (10)         (10)         (10)         (9)          
      Inflammation, Chronic Active                                                            1 (10%)                               
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Degeneration                                                                                                      1 (11%)     
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 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage, Acute                                                          1 (10%)                                            
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)         (10)         (9)          
      Inflammation, Chronic Active                     1 (10%)                   1 (10%)                   1 (10%)      3 (33%)     
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Suppurative                        1 (10%)                                                                      
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Mineralization                                  10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)     8 (89%)     
      Nephropathy, Chronic                             6 (60%)      3 (30%)      5 (50%)      3 (30%)      2 (20%)      3 (33%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                  1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            9           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Basophilic Focus                                                           1 (10%)                                            
      Hepatodiaphragmatic Nodule                       2 (20%)                   2 (20%)      1 (10%)                   1 (10%)     
      Hepatocyte, Degeneration                                                   4 (40%)      7 (70%)      9 (90%)     10 (100%)    
      Hepatocyte, Necrosis                             1 (10%)                                                                      
      Hepatocyte, Centrilobular, Hypertrophy                                                               3 (30%)      6 (60%)     
   Salivary Glands                                    (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
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 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                   2 (20%)      7 (70%)      6 (60%)      2 (20%)      1 (10%)                  
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                   1 (10%)                                                         
      Inflammation, Chronic Active                                                                                      3 (30%)     
   Prostate                                           (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation                                                                                         1 (10%)                  
      Inflammation, Chronic Active                                                                                      1 (10%)     
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 89002-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 28 DAY                                          PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:26:51  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      800 PPM      1600 PPM     3200 PPM        
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT                                                                                                               
      Germinal Epithelium, Degeneration                                                                                10 (100%)    
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                     3 (30%)                                1 (10%)      2 (20%)      4 (40%)     
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                    10 (100%)     1 (10%)      5 (50%)      3 (30%)      1 (10%)      1 (10%)     
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                                4 (40%)      2 (20%)      1 (10%)                               
      Nephropathy, Chronic                             7 (70%)      9 (90%)      5 (50%)      8 (80%)      7 (70%)      3 (30%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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